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Effects of ACS and EPS treatments on corrosion behavior of 510L low alloy steel in atmospheric environments 认领 引用
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作者 Shao-Hua Zhang Tian-Tian Bian +8 位作者 Bao-Sheng Liu Peng-Fei Xu Xiao-Xia Ren Ying-Hui Wei Li-Feng Hou Peng-Peng Wu Yue-Zhong Zhang Fa-Cai Shi Cong-Ying Xu 《Journal of Iron and Steel Research International》 SCIE EI CSCD 2026年第1期398-411,共14页
The atmospheric corrosion behavior of 510L low alloy steel subjected to acid-cleaned surface(ACS)and eco-pickled surface(EPS)treatments is systematically examined.After 1 year of atmospheric exposure,both ACS-and EPS-... The atmospheric corrosion behavior of 510L low alloy steel subjected to acid-cleaned surface(ACS)and eco-pickled surface(EPS)treatments is systematically examined.After 1 year of atmospheric exposure,both ACS-and EPS-treated samples demonstrate protective ability index values exceeding 2,indicating robust protective properties of the developed rust layers.The corrosion rates of ACS-and EPS-treated samples are similar.During the initial corrosion stage,γ-FeOOH emerges as the dominant corrosion product.With the prolonged atmospheric exposure,γ-FeOOH content progressively decreases through phase transformation into thermodynamically stableα-FeOOH and densely structured Fe3O4,which markedly suppresses the corrosion of the steel.Notably,the corrosion rate of the coated EPS sample is obviously lower than that of the coated ACS counterpart,which is ascribed to the distinctive micro-roughness of EPS-treated surfaces that promote mechanical interlocking with protective coatings. 展开更多
关键词 Acid-cleaned surface technology Eco-pickled surface technology Low alloy steel Corrosion behavior Atmospheric environment
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Psychological flexibility and coping behaviors in cervical cancer patients:Moderating role of illness perception 认领 引用
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作者 Yan-Fei Di Zhen Zhang +5 位作者 Qian Li Xue Han Qin Chen Xin-Ying He Peng-Fei Xu Hai-Xiang Wang 《World Journal of Clinical Oncology》 2026年第5期115-123,共9页
BACKGROUND Cervical cancer poses significant physical and psychological challenges,often leading to maladaptive coping behaviors that affect treatment adherence and quality of life.While psychological flexibility is k... BACKGROUND Cervical cancer poses significant physical and psychological challenges,often leading to maladaptive coping behaviors that affect treatment adherence and quality of life.While psychological flexibility is known to promote adaptive coping,its relationship with coping behaviors in cervical cancer patients remains underexplored,and the potential moderating role of illness perception in this association has not been established.AIM To explore the relationship between psychological flexibility and cancer coping behaviors in patients with cervical cancer,and to analyze the moderating role of illness perception in this relationship.METHODS A convenience sampling method was used to select 216 patients with cervical cancer for inclusion in this study.The Multidimensional Psychological Flexibility Inventory-24,Cancer Behavior Scale-3.0,and Brief Illness Perception Questionnaire were used for data collection.SPSS 26.0 software was applied for descriptive statistics,Pearson correlation analysis,and hierarchical regression analysis were also performed.RESULTS The total psychological flexibility score in patients with cervical cancer was 65.32±10.25.The score of the positive coping dimension in cancer coping behaviors was 38.67±7.54,and the score of the negative coping dimension was 25.43±6.89.The total illness perception score was 42.15±8.36.Pearson correlation analysis showed that psychological flexibility was significantly positively correlated with positive coping behaviors(r=0.452,P0.05).CONCLUSION Higher levels of psychological flexibility in patients with cervical cancer are associated with a greater tendency to adopt positive coping behaviors.Illness perception enhances the effect of psychological flexibility on negative coping behaviors. 展开更多
关键词 Cervical cancer Psychological flexibility Cancer coping behavior Illness perception Moderating effect
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High damping capacity of Ni-Mn-Ga-Cu microwires prepared by melt-extraction technique 认领 引用
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作者 Xue-Xi Zhang Ming-Fang Qian +3 位作者 Guang-Wei Wang Peng-Fei Xu Lin Geng Jian-Fei Sun 《Rare Metals》 SCIE EI CAS CSCD 2025年第10期7889-7894,共6页
Ni-Mn-Ga-Cu microwires,with diameter of 20-80 μm,length of 30-150 mm and fined columnar grains,were produced by melt-extraction technique.The damping capacity of the extracted micro wires was investigated by stretchi... Ni-Mn-Ga-Cu microwires,with diameter of 20-80 μm,length of 30-150 mm and fined columnar grains,were produced by melt-extraction technique.The damping capacity of the extracted micro wires was investigated by stretching a micro wire under a tensile stress using dynamic mechanical analyzer.The damping capacity of the martensite and austenite phases shows a weak frequency dependence but a strong strain amplitude dependence.The damping capacity(Tanδ) of the martensite and austenite phases reaches 0.08 and 0.04,respectively,under strain amplitude of 0.5% and frequency of 1 Hz.The high damping capacity of the martensite phase is related to the high mobility of martensite twin boudaries,while that of austenite phase to the motion of dislocations.The ferromagnetic Ni-Mn-Ga-Cu micro wires,with high ductility and damping capacity,may act as promising materials for microscale devices,systems and composite fillers for passive dissipation of undesired vibrations and noises. 展开更多
关键词 Shape memory alloys Phase transformation Damping capacity Ni-Mn-Ga-Cu alloy
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Progress in corrosion-resistant coatings on surface of low alloy steel 认领 引用 被引量：3
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作者 Bao-sheng Liu Jia-li Li +3 位作者 Wen-jie Guo Peng-fei Xu Shao-hua Zhang Yue-zhong Zhang 《Journal of Iron and Steel Research International》 SCIE EI CAS CSCD 2023年第2期193-215,共23页
Low alloy steels are widely used in bridges,construction,chemical and various equipment and metal components due to their low cost and excellent mechanical strength.Information in the literature related to the prepara... Low alloy steels are widely used in bridges,construction,chemical and various equipment and metal components due to their low cost and excellent mechanical strength.Information in the literature related to the preparation,advantages and disadvantages,and applications along with research progress of various types of protective coatings suitable for low-alloy steel surfaces is reviewed,while a conclusive and comparative analysis is also afforded to the numerous factors influencing the protective ability of coatings.The characteristics of coatings drawn from the latest published literature are discussed and suggest that the modification of traditional metal coatings and the development of new organic coatings under the consideration of environmental protection,low cost,simplicity and large-scale industrial application are simultaneously proceeding,which holds promise for improving the understanding of corrosion protection in related fields and helps to address some of the limitations identified with more conventional coating techniques. 展开更多
关键词 Low alloy steel Corrosion-resistant coating Metal coating Composite coating Diffusion coating Organic coating
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Prognostic role of the ABO blood types in Chinese patients with curatively resected non-small cell lung cancer:a retrospective analysis of 1601 cases at a single cancer center 认领 引用 被引量：9
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作者 Ning Li Miao Xu +7 位作者 Chao-Feng Li Wei Ou Bao-Xiao Wang Song-Liang Zhang Peng-Fei Xu Cheng Yuan Qun-Ai Huang Si-Yu Wang 《Chinese Journal of Cancer》 2015年第10期475-482,共8页
Background:A positive association between the ABO blood types and survival has been suggested in several malignancies.The aim of this study was to assess the role of the ABO blood types in predicting the prognosis of ... Background:A positive association between the ABO blood types and survival has been suggested in several malignancies.The aim of this study was to assess the role of the ABO blood types in predicting the prognosis of Chinese patients with curatively resected non-small cell lung cancer(NSCLC).Methods:We retrospectively analyzed 1601 consecutive Chinese patients who underwent curative surgery for NSCLC between January 1,2005 and December 31,2009.The relationship between the ABO blood types and survival was investigated.In addition,univariate and multivariate analyses were performed.Results:Group 1(patients with the blood type O or B) had significantly prolonged overall survival(OS) compared with group 2(patients with the blood type A or AB),with a median OS of 74.9 months versus 61.5 months[hazard ratio(HR) 0.83;95%confidence interval(CI) 0.72-0.96;P = 0.015].Additionally,group 1 had significantly longer disease-free survival(DFS;HR 0.86;95%CI 0.76-0.98;P = 0.022) and locoregional relapse-free survival(LRFS;HR 0.79;95%CI 0.64-0.98;P = 0.024) than group 2.The association was not significantly modified by other risk factors for NSCLC,including smoking status,pathologic tumor-node-metastasis stage,pT category,pN category,and chemotherapy.Conclusions:There is an association between the ABO blood types and the survival of Chinese patients with resected NSCLC.Patients with the blood type O or B had significantly prolonged OS,DFS,and LRFS compared with those with the blood type A or AB. 展开更多
关键词 The ABO blood types, Lung cancer, Prognosis, Survival
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Diabetes and gut microbiota 认领 引用 被引量：8
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作者 Yue Xi Peng-Fei Xu 《World Journal of Diabetes》 SCIE 2021年第10期1693-1703,共11页
The prevalence of diabetes has increased rapidly throughout the world in recent years.Currently,approximately 463 million people are living with diabetes,and the number has tripled over the last two decades.Here,we de... The prevalence of diabetes has increased rapidly throughout the world in recent years.Currently,approximately 463 million people are living with diabetes,and the number has tripled over the last two decades.Here,we describe the global epidemiology of diabetes in 2019 and forecast the trends to 2030 and 2045 in China,India,USA,and the globally.The gut microbiota plays a major role in metabolic diseases,especially diabetes.In this review,we describe the interaction between diabetes and gut microbiota in three aspects:probiotics,antidiabetic medication,and diet.Recent findings indicate that probiotics,antidiabetic medications,or dietary interventions treat diabetes by shifting the gut microbiome,particularly by raising beneficial bacteria and reducing harmful bacteria.We conclude that targeting the gut microbiota is becoming a novel therapeutic strategy for diabetes. 展开更多
关键词 Diabetes Gut microbiota Epidemiology Probiotics Anti-diabetic medication Diet
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Comparison of corrosion mechanisms of 510L low alloy steel treated by ACS and EPS techniques under various service environments 认领 引用
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作者 Bao-sheng Liu Peng-fei Xu +6 位作者 Shao-hua Zhang Yan-rui Li Li-ming Mou Jia-li Li Yue-zhong Zhang Pei-mao Fu Fa-cai Shi 《Journal of Iron and Steel Research International》 SCIE EI CAS CSCD 2024年第2期501-518,共18页
The corrosion mechanism of 510L low alloy steel treated by acid-cleaned surface(ACS)and eco-pickled surface(EPS)techniques in three simulated solutions(S0:atmospheric environment;S1:soil environment;S2:industrial envi... The corrosion mechanism of 510L low alloy steel treated by acid-cleaned surface(ACS)and eco-pickled surface(EPS)techniques in three simulated solutions(S0:atmospheric environment;S1:soil environment;S2:industrial environment)and the influence of interaction between different corrosive anions on corrosion were investigated.The results show that the total corrosion rates of samples in three simulated solutions were in order of S2>S0>S1,which is simultaneously correlated with initial corrosion dissolution processes as well as after the formation of corrosion products.HCO3−will inhibit the initial corrosion owing to the formation of films,whereas HSO3−will accelerate the dissolutions of the matrix based on the synergistic action of HSO3−and Cl−.On the other hand,there is no significant difference in corrosion rates between the samples treated by ACS and EPS techniques.The EPS technique that is safe,reusable and environmentally friendly can be further widely used in future work. 展开更多
关键词 Corrosion mechanism Low alloy steel Simulated solution Surface technique Immersion time
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Therapeutic potentials of fasudil in liver fibrosis 认领 引用
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作者 Yue Xi Peng-Fei Xu 《World Journal of Gastroenterology》 SCIE CAS 2021年第45期7859-7861,共3页
Fasudil has the potential to prevent liver fibrosis by activating natural killer cells and inhibiting the proliferation of hepatic stellate cells.Fasudil may be a promising clinical therapeutic drug for the prevention... Fasudil has the potential to prevent liver fibrosis by activating natural killer cells and inhibiting the proliferation of hepatic stellate cells.Fasudil may be a promising clinical therapeutic drug for the prevention and treatment of liver fibrosis. 展开更多
关键词 Fasudil Liver fibrosis Natural killer cell Hepatic stellate cell Clinical therapeutic drug
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Nano-friction phenomenon of Frenkel-Kontorova model under Gaussian colored noise 认领 引用
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作者 Yi-Wei Li Peng-Fei Xu Yong-Ge Yang 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第5期197-202,共6页
The nano-friction phenomenon in a one-dimensional Frenkel-Kontorova(FK)model under Gaussian colored noise is investigated by using the molecular dynamic simulation method.The role of colored noise is analyzed through ... The nano-friction phenomenon in a one-dimensional Frenkel-Kontorova(FK)model under Gaussian colored noise is investigated by using the molecular dynamic simulation method.The role of colored noise is analyzed through the inclusion of a stochastic force via a Langevin molecular dynamics method.Via the stochastic Runge-Kutta algorithm,the relationship between different parameter values of the Gaussian colored noise(the noise intensity and the correlation time)and the nano-friction phenomena such as hysteresis,the maximum static friction force is separately studied here.Similar results are obtained from the two geometrically opposed ideal cases:incommensurate and commensurate interfaces.It was found that the noise strongly influences the hysteresis and maximum static friction force and with an appropriate external driving force,the introduction of noise can accelerate the motion of the system,making the atoms escape from the substrate potential well more easily.Interestingly,suitable correlation time and noise intensity give rise to super-lubricity.It is noteworthy that the difference between the two circumstances lies in the fact that the effect of the noise is much stronger on triggering the motion of the FK model for the commensurate interface than that for the incommensurate interface. 展开更多
关键词 Frenkel-Kontorova model Gaussian colored noise hysteresis super-lubricity
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Crohn’s disease as the intestinal manifestation of pan-lymphatic dysfunction:An exploratory proposal based on basic and clinical data 认领 引用 被引量：3
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作者 Yu-Wei Zhou Yue Ren +16 位作者 Miao-Miao Lu Ling-Ling Xu Wei-Xin Cheng Meng-Meng Zhang Lin-Ping Ding Dong Chen Jian-Guo Gao Juan Du Ci-Liang Jin Chun-Xiao Chen Yun-Fei Li Tao Cheng Peng-Lei Jiang Yi-Da Yang Peng-Xu Qian Peng-Fei Xu Xi Jin 《World Journal of Gastroenterology》 SCIE CAS 2024年第1期34-49,共16页
Crohn’s disease(CD)is caused by immune,environmental,and genetic factors.It can involve the entire gastrointestinal tract,and although its prevalence is rapidly increasing its etiology remains unclear.Emerging biolog... Crohn’s disease(CD)is caused by immune,environmental,and genetic factors.It can involve the entire gastrointestinal tract,and although its prevalence is rapidly increasing its etiology remains unclear.Emerging biological and small-molecule drugs have advanced the treatment of CD;however,a considerable proportion of patients are non-responsive to all known drugs.To achieve a breakthrough in this field,innovations that could guide the further development of effective therapies are of utmost urgency.In this review,we first propose the innovative concept of pan-lymphatic dysfunction for the general distribution of lymphatic dysfunction in various diseases,and suggest that CD is the intestinal manifestation of pan-lymphatic dysfunction based on basic and clinical preliminary data.The supporting evidence is fully summarized,including the existence of lymphatic system dysfunction,recognition of the inside-out model,disorders of immune cells,changes in cell plasticity,partial overlap of the underlying mechanisms,and common gut-derived fatty and bile acid metabolism.Another benefit of this novel concept is that it proposes adopting the zebrafish model for studying intestinal diseases,especially CD,as this model is good at presenting and mimicking lymphatic dysfunction.More importantly,the ensuing focus on improving lymphatic function may lead to novel and promising therapeutic strategies for CD. 展开更多
关键词 Inflammatory bowel disease Crohn’s disease Lymphatic system Inside-out model Immune cells Zebrafish
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Triplet energy-driven:σ-bond insertion strategy for modular access to 2-substituted bicyclo[1.1.1]pentanes 认领 引用
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作者 Teng-Fei Xiao Ming-Ming Li +4 位作者 Dong Xie Yu-Cheng Gu Pan-Pan Zhou Guo-Qiang Xu Peng-Fei Xu 《Science China Chemistry》 SCIE EI CAS CSCD 2026年第6期2951-2957,共7页
Bicyclo[1.1.1]pentanes(BCPs)have emerged as valuable saturated bioisosteres of arenes in drug discovery.While 1,3-disubstituted BCPs are increasingly accessible,the pharmaceutical value of 2-substituted BCPs as replac... Bicyclo[1.1.1]pentanes(BCPs)have emerged as valuable saturated bioisosteres of arenes in drug discovery.While 1,3-disubstituted BCPs are increasingly accessible,the pharmaceutical value of 2-substituted BCPs as replacements for MIMIC ortho-/meta-substituted arene rings,modular access to these scaffolds remains elusive.Here we report a visible-light-mediatedσ-bond insertion strategy that exploits triplet energy transfer catalysis to convert readily available bicyclo[1.1.0]butanes(BCBs)into 2-substituted BCPs.The reaction proceeds via triplet carbene intermediates that engage in regioselective insertion into the central C–Cσ-bond of BCBs.Mechanistic studies,supported by radical trapping experiments,Stern-Volmer analysis,light-dependence assays,and density functional theory(DFT)calculations,reveal a radical mechanism.The key challenges in this transformation include:controlling the highly reactive radical intermediates;achieving regioselective addition to the highly strained BCB(strain energy:53.8 kcal/mol),and reconstructing the highly strained BCP ring(strain energy:54.4 kcal/mol)during radical coupling. 展开更多
关键词 2-substituted bicyclo[1.1.1]pentanes bioisosteres photocatalytic energy-transfer
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Investigation of Ga2O3/diamond heterostructure solar-blind avalanche photodiode via TCAD simulation 认领 引用
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作者 许敦洲 金鹏 +3 位作者 徐鹏飞 冯梦阳 吴巨 王占国 《Chinese Physics B》 SCIE EI CAS CSCD 2023年第10期716-723,共8页
A Ga2O3/diamond separate absorption and multiplication avalanche photodiode(SAM-APD)with mesa structure has been proposed and simulated.The simulation is based on an optimized Ga2O3/diamond heterostructure... A Ga2O3/diamond separate absorption and multiplication avalanche photodiode(SAM-APD)with mesa structure has been proposed and simulated.The simulation is based on an optimized Ga2O3/diamond heterostructure TCAD physical model,which is revised by repeated comparison with the experimental data from the literature.Since both Ga2O3and diamond are ultra-wide bandgap semiconductor materials,the Ga2O3/diamond SAM-APD shows good solar-blind detection ability,and the corresponding cutoff wavelength is about 263 nm.The doping distribution and the electric field distribution of the SAM-APD are discussed,and the simulation results show that the gain of the designed device can reach 5×104and the peak responsivity can reach a value as high as 78 A/W. 展开更多
关键词 Ga2O3 diamond separate absorption and multiplication avalanche photodiode(SAM-APD) solar-blind detector
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H101对胃癌细胞增殖、迁移、凋亡的调控作用及其相关机制研究 认领 引用
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作者 邵苏 徐鹏飞 占小平 《世界华人消化杂志》 CAS 2022年第18期803-809,共7页
背景溶瘤病毒作为治疗癌症的新手段,具有疗效快,靶向性强,无细胞毒性等特点,H101作为商品化上市的溶瘤病毒表现出了稳定的抗癌特效,为中晚期胃癌患者的腹膜转移治疗提供了可能.目的探讨H101对胃癌细胞增殖、迁移、凋亡的调控作用及其相... 背景溶瘤病毒作为治疗癌症的新手段,具有疗效快,靶向性强,无细胞毒性等特点,H101作为商品化上市的溶瘤病毒表现出了稳定的抗癌特效,为中晚期胃癌患者的腹膜转移治疗提供了可能.目的探讨H101对胃癌细胞增殖、迁移、凋亡的调控作用及其相关机制研究.方法将BGC-823和SGC-7901两种胃癌细胞系培养在6孔板中,分别加入感染复数(multiplicity of infection,MOI)值为1、5、10、15的H101,作用48 h后,用MTS法检测细胞的存活率,免疫印迹法(western blot,WB)检测腺病毒早期区1(adenovirus early region 1,E1A)的表达.选取SGC-7901细胞,用划痕法检测各组细胞48 h的迁移率,Hoechst33342染液,观察H101作用48 h后凋亡小体的形成情况.Western blot检测细胞凋亡相关蛋白的表达.结果WB结果显示,H101中的EIA表达量比对照组更高,差异具有统计学意义(P<0.05).MTS结果显示与MOI值为1时相比,MOI值为15的时候,H101在体外可以明显杀伤BGC-823和SGC-79012种胃癌肿瘤细胞(P<0.05).在增殖实验中发现相对于BGC-823细胞,SGC-7901细胞对H101的敏感性更差,因此选取敏感性相对较差的SGC-7901细胞作为研究重点.48 h后,与对照组和MOI=1组的迁移距离相比,MOI=5组,MOI=10组和MOI=15组的迁移距离明显更低,(P均<0.05).与MOI=1组相比,MOI=5、MOI=10和MOI=15组的凋亡小体数量更多(P均<0.05),与对照组和MOI=1组相比,MOI=5、MOI=5和MOI=10组的B淋巴细胞瘤-2蛋白(B-cell lymphoma-2,Bcl-2)表达量较低(P均<0.05),而凋亡蛋白(BCL2-associated X,Bax)、半胱氨酸蛋白酶-3(cysteinyl aspartate specific proteinase-3,Caspase-3)表达量均更高(P均<0.05).结论H101能够抑制胃癌细胞的增殖、迁移,提高细胞凋亡相关蛋白的表达量,加速细胞的凋亡. 展开更多
关键词 H101 胃癌 增殖 迁移 凋亡
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Current susceptibilities of brown planthopper Nilaparvata lugens to triflumezopyrim and other frequently used insecticides in China 认领 引用 被引量：22
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作者 Xun Liao Peng-Fei Xu +2 位作者 Pei-Pan Gong Hu Wan Jian-Hong Li 《Insect Science》 SCIE CAS CSCD 2021年第1期115-126,共12页
The brown planthopper is a notorious rice pest in many areas of Asia.The evolution of insecticide resistance in Nilaparvata lugens has become a serious problem in the effective control of this pest in the paddy field.... The brown planthopper is a notorious rice pest in many areas of Asia.The evolution of insecticide resistance in Nilaparvata lugens has become a serious problem in the effective control of this pest in the paddy field.In this article,the current susceptibility of N.lugens field populations to novel mesoionic insecticide triflumezopyrim and major classes of chemical insecticides was determined and compared.The monitoring results indicated that field populations of N.lugens had developed low resistance to triflumezopyrim(resistance ratio,RR:1.3-7.3-fold)during 2015-2018 in China,and the median lethal concentration values varied from 0.05 to 0.29 mg/L.Additionally,during 2017 to 2018,field populations of N.lugens showed high resistance levels to thiamethoxam(RR:456.1-1025.6-fold),imidacloprid(RR:2195.3-6899.0-fold)and buprofezin(RR:1241.57521.7-fold),moderate to high resistance levels to dinotefuran(RR:97.6-320.1-fold),clothianidin(RR:69.4-230.1-fold)and isoprocarb(RR:44.1-108.0-fold),and low to moderate levels of resistance to chlorpyrifos(RR:12.0-29.7-fold)and nitenpyram(RR:6.9-24.1-fold).In contrast,N.lugens just showed low resistance to sulfoxaflor(RR:3.3-8.5-fold)and etofenprox(RR:5.0-9.1-fold)in the field.Additionally,the P450 gene CYP6ER1 was found to be significantly overexpressed in all five field populations of N.lugens collected in 2018 when compared with a laboratory susceptible strain.Our findings will provide useful information to delay the evolution of insecticide resistance in N.lugens. 展开更多
关键词 Nilaparvata lugens(Stal) P450 gene susceptibility triflumezopyrim
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Catalytically generated noncovalent ammonium dienolate:a versatile platform for the development of organocatalytic asymmetric cascade reactions 认领 引用 被引量：3
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作者 Jun-Bing Lin Dong-Sheng Ji Peng-Fei Xu 《Science China Chemistry》 SCIE EI CAS CSCD 2024年第8期2524-2546,共23页
Organocatalytic cascade reactions represent a powerful strategy for the rapid construction of complex chiral molecules with multiple stereocenters from simple substrates under mild conditions. The intriguing structura... Organocatalytic cascade reactions represent a powerful strategy for the rapid construction of complex chiral molecules with multiple stereocenters from simple substrates under mild conditions. The intriguing structural feature and diverse reactivity of catalytically generated dienolate species render them competent and versatile intermediates for the development of practical and valuable cascade reactions. Over the past years, a plethora of innovative and pioneering noncovalent ammonium dienolatemediated cascade reactions have been designed and implemented under the catalysis of chiral organocatalysts, making dienolate activation a general, robust, and complementary method for the functionalization of unsaturated carbonyl compounds and related substances. This review illustrates the recent advances in organocatalytic noncovalent ammonium dienolate-mediated cascade reactions(mainly from 2010 to 2023), including the cascade transformations of ammonium dienolates directly generated from unsaturated ketone/aldehyde, ester/lactone/azlactone, amide/lactam/pyrazolone/oxindole, and alkylidene nitrile compounds. The contents are arranged based on the reaction types of the ammonium dienolates, with an emphasis on cascade 2,5-, 3,5-, and 4,5-difunctionalizations of these intermediates. Furthermore, other cascade reactions involving the 1,3-, 2,3-, and even more complex 3,4,5-reactivities of ammonium dienolates were also discussed. The reaction pathway, reaction stereoinduction, and synthetic applications of the ammonium dienolate-mediated cascade reactions were highlighted throughout the article. As a stimulating and ever-growing research area, the organocatalytic noncovalent ammonium dienolate-mediated cascade reactions are expected to continue demonstrating their magic power for constructing chiral targets in the future and further expanding the boundaries of asymmetric catalysis. 展开更多
关键词 organocatalysis asymmetric catalysis ammonium dienolate cascade reaction difunctionalization
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Deciphering and reconstitution of positional information in the human brain development 认领 引用 被引量：2
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作者 Yi-Fan Wang Cong Liu Peng-Fei Xu 《Cell Regeneration》 CAS 2021年第1期303-315,共13页
Organoid has become a novel in vitro model to research human development and relevant disorders in recent years.With many improvements on the culture protocols, current brain organoids could self-organize into a compl... Organoid has become a novel in vitro model to research human development and relevant disorders in recent years.With many improvements on the culture protocols, current brain organoids could self-organize into a complicatedthree-dimensional organization that mimics most of the features of the real human brain at the molecular, cellular,and further physiological level. However, lacking positional information, an important characteristic conveyedby gradients of signaling molecules called morphogens, leads to the deficiency of spatiotemporally regulated cellarrangements and cell–cell interactions in the brain organoid development. In this review, we will overview the roleof morphogen both in the vertebrate neural development in vivo as well as the brain organoid culture in vitro, thestrategies to apply morphogen concentration gradients in the organoid system and future perspectives of the brainorganoid technology. 展开更多
关键词 culture arrangement apply
Photoredox-Catalyzed Hydrocarboxymethylation of Alkenes 认领 引用
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作者 Jie Fang Qiang Hu +4 位作者 Wan-Li Dong Guo-Qiang Xu Xiu-Qin Hu Yong-Chun Luo Peng-Fei Xu 《CCS Chemistry》 CSCD 2021年第10期95-104,共10页
Direct introduction of a carboxyl group into molecules is one of the most useful methods for the preparation of carboxylic acids,which avoids the conversion of various preexisting functional groups and features good s... Direct introduction of a carboxyl group into molecules is one of the most useful methods for the preparation of carboxylic acids,which avoids the conversion of various preexisting functional groups and features good step-and atom-economy.However,the methods for the direct synthesis of two-carbon added carboxylic acids from the precursors remain rare.Herein,we first report a general and mild method for the direct synthesis of a range of aliphatic acids by photoredox-catalyzed hydrocarboxymethylation of alkenes with good toleration of various functional groups in which bromoacetic acid is utilized as an ideal two-carbon synthon. 展开更多
关键词 photoredox catalysis unactivated alkenes bromoacetic acid two-carbonsynthon fatty acids
New strategies for asymmetric photocatalysis: asymmetric organocatalytic/photoredox relay catalysis for efficient synthesis of polycyclic compounds containing vicinal amino alcohols 认领 引用 被引量：4
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作者 Jia-Lu Zhang Wen-Bo He +1 位作者 Xiu-Qin Hu Peng-Fei Xu 《Science China Chemistry》 SCIE EI CAS CSCD 2024年第3期945-952,共8页
An asymmetric catalytic strategy in photocatalysis utilizing a chirality-induced approach through an organocatalytic/photoredox relay catalysis strategy is successfully achieved for the rapid construction of polycycli... An asymmetric catalytic strategy in photocatalysis utilizing a chirality-induced approach through an organocatalytic/photoredox relay catalysis strategy is successfully achieved for the rapid construction of polycyclic compounds containing vicinal amino alcohols in a one-pot protocol. This methodology facilitates the efficient synthesis of diverse substituted polycyclic tetrahydroquinoline and benzofuran-derived vicinal amino alcohols, each containing five consecutive chiral centers, with high yields,excellent diastereoselectivities and enantioselectivities(up to 95% yield, >20:1 dr and 98% ee), under mild reaction conditions driven by sequential bifunctional squaramide organocatalyst-catalyzed [4+2] annulation and photocatalyst-catalyzed ketyl radical addition cyclization reaction process. Furthermore, investigations into the stereoselectivity mechanism and high-resolution mass spectrometry(HRMS) experiments on free radical trapping have provided evidence for elucidating the detailed mechanism of chirality-induced processes and chiral intermediate conversions in this procedure. 展开更多
关键词 enantioselective photocatalysis asymmetric organocatalytic/photocatalysis relay catalysis five consecutive chiral centers chirality-induced strategy chirality vicinal amino alcohols
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Visible-light induced generation of bifunctional nitrogen-centered radicals:a concise synthetic strategy to construct bicyclo[3.2.1]octane and azepane cores 认领 引用
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作者 Wan-Lei Yu Hao-Wen Jiang +3 位作者 Lei Yan Zhi-Tao Feng Yong-Chun Luo Peng-Fei Xu 《Science China Chemistry》 SCIE EI CAS CSCD 2021年第2期274-280,共7页
A photocatalytic tandem cyclization of o-alkenylbenzaldehydes using pyridinium salts as the amination reagent is described.A variety of valuable seven-membered nitrogenous heterocyclic skeletons are prepared in modest... A photocatalytic tandem cyclization of o-alkenylbenzaldehydes using pyridinium salts as the amination reagent is described.A variety of valuable seven-membered nitrogenous heterocyclic skeletons are prepared in modest to excellent yields in concise one-step.This transformation features mild reaction conditions and exceptional functional group tolerance.In addition,combining control experiments and density functional theory(DFT)calculations on the mechanism can explain the reaction selectivity. 展开更多
关键词 photoredox catalysis nitrogen-centered radicals bicyclo[3.2.1]octane azepane 1,5-hydrogen atom transfer
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Regiodivergent Access to 2- or 3-Substituted Indanones: Catalyst-Controlled Carboacylation via C–C Bond Activation 认领 引用
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作者 Pengcheng Shao Tianyang Yu +2 位作者 Hong Lu Peng-Fei Xu Hao Wei 《CCS Chemistry》 CSCD 2021年第8期1862-1871,共10页
Indanones are ubiquitous in biologically active compounds.Intramolecular hydroacylation of aldehydes and alkenes is an efficient and atomeconomic route to indane rings.However,these reactions are limited to the transf... Indanones are ubiquitous in biologically active compounds.Intramolecular hydroacylation of aldehydes and alkenes is an efficient and atomeconomic route to indane rings.However,these reactions are limited to the transfer of a hydride to the alkene.The transfer of aryl groups enabling the formation of C–C bonds during the cyclization would be a new method for the synthesis of substituted indanones.This report describes the regiodivergent carboacylation of alkenes with ketones to furnish both 2-and 3-substituted indanones in a regiocontrolled manner. 展开更多
关键词 C–C bond activation indanones divergent synthesis directing group carboacylation
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