N6-methyladenosine(m6A)is a prevalent mRNA modification that is essential for diverse biological processes.Recent advances in high-throughput sequencing,including RNA immunoprecipitation sequencing(RIP-seq)and n...N6-methyladenosine(m6A)is a prevalent mRNA modification that is essential for diverse biological processes.Recent advances in high-throughput sequencing,including RNA immunoprecipitation sequencing(RIP-seq)and nanopore direct RNA sequencing(dRNA-seq),have enabled comprehensive profiling of m6A methylomes across tissues,conditions,and species.Correspondingly,numerous bioinformatics tools and databases have been developed to mine these datasets.展开更多
基金supported by the National Natural Science Foundation of China(32170681 and 32470717)the Natural Science Foundation of Shaanxi Province,China(2024JC-YBMS-112)the Doctoral Startup Fund of Northwest A&F University(2452023033).
摘要N6-methyladenosine(m6A)is a prevalent mRNA modification that is essential for diverse biological processes.Recent advances in high-throughput sequencing,including RNA immunoprecipitation sequencing(RIP-seq)and nanopore direct RNA sequencing(dRNA-seq),have enabled comprehensive profiling of m6A methylomes across tissues,conditions,and species.Correspondingly,numerous bioinformatics tools and databases have been developed to mine these datasets.