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Decreased IL-33 in the brain following repetitive mild traumatic brain injury contributes to cognitive impairment by inhibiting microglial phagocytosis 认领 引用 被引量：1
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作者 Ze-Xi Jia Meng-Tian Guo +11 位作者 Mei-Mei Li Pan Liao Bo Yan Wei Zhang Fang-Yuan Cheng Ya-Ru Liu Zi-Han Zhang Cheng Wei Jie Zhou Fang-Lian Chen Ping Lei Xin-Tong Ge 《Military Medical Research》 SCIE CAS CSCD 2026年第1期24-42,共19页
Background:Repetitive mild traumatic brain injury(rmTBI)is a significant risk factor for neurodegeneration,characterized by pathological protein deposition and persistent neuroinflammation.Research has observed increa... Background:Repetitive mild traumatic brain injury(rmTBI)is a significant risk factor for neurodegeneration,characterized by pathological protein deposition and persistent neuroinflammation.Research has observed increased interleukin-33(IL-33)levels in the peripheral blood of patients with rmTBI,suggesting IL-33 may participate in regulating the pathological development of rmTBI.The study aims to elucidate the impact and mechanism of IL-33 in the progression of neuropathology following rmTBI,and to explore its potential as a therapeutic target to improve the neurological outcome.Methods:The study employed an rmTBI mouse model using the wild-type(WT)and IL-33 knockout mice.Cognitive function was assessed via the Y-maze and Barnes tests.The main cell type expressing IL-33 and its receptor,suppression of tumorigenicity 2(ST2),was then investigated in the mouse brain through immunofluorescence colocalization.As the primary neural cell responsible for ST2 expression,microglia were studied in vitro using the BV2 cell line.The effects of lipid droplets(LDs)accumulation and amyloid-beta(Aβ)phagocytosis were measured to elucidate the impact of IL-33 on BV2 cells'phagocytosis.Additionally,HT22 neuronal apoptosis was assessed by flow cytometry.Finally,the cognitive effects of intranasal administration of IL-33 were evaluated in mice.Results:IL-33 KO mice exhibited pronounced cognitive impairment after rmTBI.In the mouse brain,astrocytes were identified as the primary source of IL-33 secretion,while microglia predominantly expressed ST2.Transcriptome sequencing revealed that IL-33 significantly influenced phagocytosis function.IL-33 mitigated LDs accumulation in BV2 cells and enhanced Aβphagocytosis in vitro.In addition,the culture medium of BV2 cells with activated IL-33/ST2 signaling reduced HT22 neuronal apoptosis and axonal damage.Furthermore,intranasal administration of IL-33 was observed to be effective in alleviating neurodegeneration and cognitive outcome of rmTBI mice.Conclusions:Dysfunction of the IL-33/ST2 axis following rmTBI leads to cognitive dysfunction via impairing microglial phagocytosis capacity and promoting neuronal damage.IL-33 would be a promising therapeutic target for alleviating neurodegeneration following rmTBI. 展开更多
关键词 Repetitive mild traumatic brain injury(rmTBI) Interleukin-33(IL-33) Microglia Cognition
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Computed tomographic angiography measured right gastroepiploic artery length and anastomotic leakage after McKeown esophagectomy: A retrospective cohort study 认领 引用
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作者 Babou Sowe Ping Lei +3 位作者 Guo-Xu Tang Feng-Jing Yang Si-Hua Wang Tong Song 《World Journal of Gastrointestinal Surgery》 SCIE 2026年第4期55-64,共10页
BACKGROUND Anastomotic leakage(AL)is a serious complication following McKeown esophagectomy(MKE),associated with increased postoperative morbidity and mortality.The right gastroepiploic artery(RGEA)is the principal bl... BACKGROUND Anastomotic leakage(AL)is a serious complication following McKeown esophagectomy(MKE),associated with increased postoperative morbidity and mortality.The right gastroepiploic artery(RGEA)is the principal blood supply to the gastric conduit,yet its role in AL risk remains incompletely defined.This study aimed to evaluate the relationship between preoperative computed tomographic angiography(CTA)measured RGEA length and the incidence of AL following MKE while exploring whether RGEA length thresholds within our cohort could serve as risk-enrichment markers to support preoperative planning.AIM To evaluate the association between preoperative CTA-measured RGEA length and AL after MKE.METHODS A total of 679 patients who underwent MKE for esophageal cancer were included and stratified into two groups based on the presence or absence of AL(AL and Non-AL).The primary endpoint was to assess the association between AL incidence and the length of the RGEA as measured by CTA.Statistical analyses were performed using EmpowerStats and R software version 4.5.1.RESULTS Among the 679 patients,109(16.10%)developed AL.Patients in the AL group had significantly shorter RGEA lengths compared with the non-AL group(P<0.001).Segmented regression analysis identified a cohort-specific threshold of 27.8 cm,below which the risk of AL increased.These findings suggest that shorter RGEA length is associated with elevated AL risk.CONCLUSION Shorter preoperative CTA-measured RGEA length is associated with a higher risk of AL.This cohort-specific threshold may serve as a risk-enrichment marker to inform perioperative planning and patient counseling. 展开更多
关键词 Esophageal cancer McKeown esophagectomy Computed tomographic angiography Right gastroepiploic artery Anastomotic leakage
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Exploring Urban Design Teaching under the Framework of the Discipline of Human Settlements 认领 引用
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作者 Mingxia LIANG Guorong LUO +1 位作者 Ping LEI Ting JIANG 《Asian Agricultural Research》 2026年第6期41-42,45,共2页
In the new era,urban design should focus not only on traditional spatial form-making,but also on human needs,sustainable development,and culture.Therefore,the core of urban design today is the human settlements.In thi... In the new era,urban design should focus not only on traditional spatial form-making,but also on human needs,sustainable development,and culture.Therefore,the core of urban design today is the human settlements.In this context,the teaching of urban design courses in universities needs to be actively reformed to cultivate talents who better meet the demands of social development.To this end,profound changes should be made throughout the entire process of course implementation,including teaching objectives,content,and methods.This paper explores these issues,hoping to cultivate new-type urban design talents equipped with systematic thinking,humanistic care,and practical innovation capabilities through the reform of teaching objectives,content,and methods. 展开更多
关键词 Sciences of human settlements Urban design Teaching in higher education institutions Systematic thinking Multidisciplinary collaboration Teaching reform
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Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis 认领 引用 被引量：10
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作者 Conglin Wang Fangyuan Cheng +9 位作者 Zhaoli Han Bo Yan Pan Liao Zhenyu Yin Xintong Ge Dai Li Rongrong Zhong Qiang Liu Fanglian Chen Ping Lei 《Neural Regeneration Research》 SCIE CAS CSCD 2025年第2期518-532,共15页
Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor prognosis.Human-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)... Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor prognosis.Human-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system diseases.In this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying mechanism.Our results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral hemorrhage.Additionally,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory microenvironment.RNA sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier integrity.Treatment with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these effects.In summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes. 展开更多
关键词 AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K
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Gut microbiota-astrocyte axis: new insights into age-related cognitive decline 认领 引用 被引量：10
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作者 Lan Zhang Jingge Wei +5 位作者 Xilei Liu Dai Li Xiaoqi Pang Fanglian Chen Hailong Cao Ping Lei 《Neural Regeneration Research》 SCIE CAS CSCD 2025年第4期990-1008,共19页
With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent worldwide.Aging is considered the main risk factor for cognitive decline and acts through alterati... With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent worldwide.Aging is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of astrocytes.The microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive function.This article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative diseases.This article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial metabolites.Finally,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s diseases.Our findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition. 展开更多
关键词 age aging Alzheimer’s disease astrocytes cognitive decline dementia gut microbiota gut–brain axis microbial metabolites neuroinflammation Parkinson’s disease
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神经酸生物合成、纯化及营养应用研究进展 认领 引用
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作者 高云旗 张逸 +6 位作者 周梦舟 陈洋 胡珊 孙周亮 郭宏涛 平磊 郑明明 《食品科学》 EI CAS CSCD 北大核心 2026年第5期13-25,共13页
神经酸是一种超长链单不饱和脂肪酸,具有促进神经再生、调节脂质代谢等生理功效,其在婴幼儿配方奶粉、保健品、医药等领域具有广泛应用潜力。本文概述动物、植物、微生物等不同来源的天然神经酸分布特点,重点探讨基于解脂耶氏酵母、圆... 神经酸是一种超长链单不饱和脂肪酸,具有促进神经再生、调节脂质代谢等生理功效,其在婴幼儿配方奶粉、保健品、医药等领域具有广泛应用潜力。本文概述动物、植物、微生物等不同来源的天然神经酸分布特点,重点探讨基于解脂耶氏酵母、圆红冬孢酵母等产油微生物生物合成神经酸的研究进展,阐明神经酸生物制造的工业化前景。在此基础上,论述神经酸的富集精制、功效评价及产品开发的发展趋势和未来展望。本综述旨在为神经酸的生物制造提供理论基础,为其工业化生产和高值化应用提供科学参考。 展开更多
关键词 神经酸 生物合成 富集精制 功能性脂质 产品开发
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ANXA2 Facilitates Enterovirus 71 Infection by Interacting with 3D Polymerase and PI4KB to Assist the Assembly of Replication Organelles 认领 引用 被引量：3
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作者 Qiuhan Zhang Siliang Li +9 位作者 Ping Lei Zixian Li Feifei Chen Qi Chen Yulu Wang Jiami Gong Qi Tang Xinjin Liu Ke Lan Shuwen Wu 《Virologica Sinica》 SCIE CAS CSCD 2021年第6期1387-1399,共13页
Similar to that of other enteroviruses, the replication of enterovirus 71(EV71) occurs on rearranged membranous structures called replication organelles(ROs). Phosphatidylinositol 4-kinase Ⅲ(PI4KB), which is required... Similar to that of other enteroviruses, the replication of enterovirus 71(EV71) occurs on rearranged membranous structures called replication organelles(ROs). Phosphatidylinositol 4-kinase Ⅲ(PI4KB), which is required by enteroviruses for RO formation, yields phosphatidylinositol-4-phosphate(PI4P) on ROs. PI4P then binds and induces conformational changes in the RNA-dependent RNA polymerase(Rd Rp) to modulate Rd Rp activity. Here, we targeted 3D polymerase, the core enzyme of EV71 ROs, and found that the host factor Annexin A2(ANXA2) can interact with 3 D polymerase and promote the replication of EV71. Then, an experiment showed that the annexin domain of ANXA2, which possesses membranebinding capacity, mediates the interaction of ANXA2 with EV71 3 D polymerase. Further research showed that ANXA2 is localized on ROs and interacts with PI4KB. Overexpression of ANXA2 stimulated the formation of PI4P, and the level of PI4P was decreased in ANXA2-knockout cells. Furthermore, ANXA2, PI4KB, and 3D were shown to be localized to the viral RNA replication site, where they form a higher-order protein complex, and the presence of ANXA2 promoted the PI4 KB-3D interaction. Altogether, our data provide new insight into the role of ANXA2 in facilitating formation of the EV71 RNA replication complex. 展开更多
关键词 Enterovirus 71(EV71) Annexin A2(ANXA2) 3D polymerase Phosphatidylinositol 4-kinaseⅢ(PI4KB)
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Selection for Anti-transferrin Receptor Bispecific T-cell Engager in Different Molecular Formats 认领 引用
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作者 Ming-peng FU Zi-long GUO +4 位作者 Hong-ling TANG Hui-fen ZHU Guan-xin SHEN Yong HE Ping LEI 《Current Medical Science》 SCIE CAS 2020年第1期28-34,共7页
Selecting an ideal molecular format from diverse structures is a major challenge in developing a bispecific antibody(BsAb).To choose an ideal format of anti-CD3 x anti-transferrin receptor(TfR)bispecific antibodies fo... Selecting an ideal molecular format from diverse structures is a major challenge in developing a bispecific antibody(BsAb).To choose an ideal format of anti-CD3 x anti-transferrin receptor(TfR)bispecific antibodies for clinical application,we constructed TfR bispecific T-cell engager(BiTE)in two extensively applied formats,including single-chain tandem singlechain variable fragments(scFvs)and double-chain diabodies,and evaluated their functional characterizations in vitro.Results demonstrated that TfR-BiTE in both formats directed potent killing of TfR+HepG2 cells.However,compared to two・chain diabodies,scFvs were more efficient in antigen binding and TfR target killing.Furthermore,different domain orders in scFvs would also be evaluated because single-TfR-CD3-His was preferable to single-CD3-TfR-His in immunotherapeutic strategies.Thus,the single-chain tandem TfR-CD3 format was favored for further investigation in cancer therapy. 展开更多
关键词 bispecific antibody single-chain tandem single-chain variable fragments diabody transferrin receptor CD3
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Effects of Strain Rate and Fiber Content on the Dynamic Mechanical Properties of Sisal Fiber Cement-Based Composites 认领 引用
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作者 Yubo Zhang Ping Lei +1 位作者 Lina Wang Jiqing Yang 《Journal of Renewable Materials》 SCIE EI CAS 2023年第1期393-410,共18页
In this paper,a split Hopkinson pressure bar(SHPB)was used to investigate the dynamic impact mechanical behavior of sisal fiber-reinforced cement-based composites(SFRCCs),and the microscopic damage evolution of the co... In this paper,a split Hopkinson pressure bar(SHPB)was used to investigate the dynamic impact mechanical behavior of sisal fiber-reinforced cement-based composites(SFRCCs),and the microscopic damage evolution of the composites was analyzed by scanning electron microscopy(SEM)and energy-dispersive X-ray spectrome-try(EDS).The results show that the addition of sisal fibers improves the impact resistance of cement-based composite materials.Compared with ordinary cement-based composites(OCCs),the SFRCCs demonstrate higher post-peak strength,ductility,and energy absorption capacity with higher fiber content.Moreover,the SFRCCs are strain rate sensitive materials,and their peak stress,ultimate strain,and energy integrals all increase with increasing strain rate.From the perspective of fracture failure characteristics,the failure of OCCs is dominated by the brittle failure of crystal cleavage.In contrast,the failure mode of the SFRCCs changes to microscale matrix cracks,multi-scale pull-out interface debonding of fibers(fine filaments and bundles),and mechanical interlock.This research provides an experimental basis for the engineering application of high-performance and green cement-based composites. 展开更多
关键词 Sisal fiber cement-based composites SHPB energy integration microstructure damage evolution law
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Exosomes derived from microglia overexpressing miR-124-3p alleviate neuronal endoplasmic reticulum stress damage after repetitive mild traumatic brain injury 认领 引用 被引量：5
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作者 Yan Wang Dai Li +12 位作者 Lan Zhang Zhenyu Yin Zhaoli Han Xintong Ge Meimei Li Jing Zhao Shishuang Zhang Yan Zuo Xiangyang Xiong Han Gao Qiang Liu Fanglian Chen Ping Lei 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第9期2010-2018,共9页
We previously reported that miR-124-3p is markedly upregulated in microglia-derived exosomes following repetitive mild traumatic brain injury.However,its impact on neuronal endoplasmic reticulum stress following repet... We previously reported that miR-124-3p is markedly upregulated in microglia-derived exosomes following repetitive mild traumatic brain injury.However,its impact on neuronal endoplasmic reticulum stress following repetitive mild traumatic brain injury remains unclear.In this study,we first used an HT22 scratch injury model to mimic traumatic brain injury,then co-cultured the HT22 cells with BV2 microglia expressing high levels of miR-124-3p.We found that exosomes containing high levels of miR-124-3p attenuated apoptosis and endoplasmic reticulum stress.Furthermore,luciferase reporter assay analysis confirmed that miR-124-3p bound specifically to the endoplasmic reticulum stress-related protein IRE1α,while an IRE1αfunctional salvage experiment confirmed that miR-124-3p targeted IRE1αand reduced its expression,thereby inhibiting endoplasmic reticulum stress in injured neurons.Finally,we delivered microglia-derived exosomes containing miR-124-3p intranasally to a mouse model of repetitive mild traumatic brain injury and found that endoplasmic reticulum stress and apoptosis levels in hippocampal neurons were significantly reduced.These findings suggest that,after repetitive mild traumatic brain injury,miR-124-3 can be transferred from microglia-derived exosomes to injured neurons,where it exerts a neuroprotective effect by inhibiting endoplasmic reticulum stress.Therefore,microglia-derived exosomes containing miR-124-3p may represent a novel therapeutic strategy for repetitive mild traumatic brain injury. 展开更多
关键词 apoptosis C/EBP homologous protein endoplasmic reticulum stress exosome inositol-requiring enzyme 1α microglia miR-124-3p neuron repetitive mild traumatic brain injury X-box binding protein 1
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血小板及其衍生相关比值与急性缺血性脑卒中相关的研究进展 认领 引用
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作者 刘荣荣 杨荣礼 +6 位作者 朱士光 卢海龙 刘建 平蕾 孙勇 石瑜 翟羽佳 《当代介入医学电子杂志》 2025年第6期61-68,共8页
急性缺血性脑卒中(AIS)是一种常见的卒中类型,具有高复发率和高致残率的特点,是导致死亡和残疾的主要原因之一。血小板在AIS的发病机制中扮演着重要角色,与动脉粥样硬化、血栓形成和神经炎症等多种病理生理过程密切相关。近年发现血小... 急性缺血性脑卒中(AIS)是一种常见的卒中类型,具有高复发率和高致残率的特点,是导致死亡和残疾的主要原因之一。血小板在AIS的发病机制中扮演着重要角色,与动脉粥样硬化、血栓形成和神经炎症等多种病理生理过程密切相关。近年发现血小板及相关比值在预测AIS的预后和转归方面具有重要的临床价值。本文综述了血小板与淋巴细胞比值(PLR)、血小板与中性粒细胞比值(PNR)、平均血小板体积与血小板(MPV/PLT)等一系列血小板相关衍生比值与AIS关系的研究进展。探讨这些相关指标与AIS的发生、严重程度、预后及并发症之间的联系,对早期制定AIS的治疗策略和改善预后具有一定的意义。 展开更多
关键词 急性缺血性卒中 血小板 动脉粥样硬化 炎症 预后 溶栓 取栓
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氧化三甲胺与缺血性脑卒中病因分型及相关治疗方法的研究进展 认领 引用
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作者 王玉坤 周楚 +4 位作者 胡业菊 孙勇 翟羽佳 平蕾 朱士光 《当代介入医学电子杂志》 2025年第1期66-73,共8页
近年来,肠道菌群代谢物氧化三甲胺(TMAO)被证实与心血管疾病及缺血性脑卒中的发生发展密切相关。研究成果表明,TMAO借助促进内皮功能受损、诱导泡沫细胞形成、提升血小板反应性以及触发血栓形成等多重机制,推动了动脉粥样硬化进程的加... 近年来,肠道菌群代谢物氧化三甲胺(TMAO)被证实与心血管疾病及缺血性脑卒中的发生发展密切相关。研究成果表明,TMAO借助促进内皮功能受损、诱导泡沫细胞形成、提升血小板反应性以及触发血栓形成等多重机制,推动了动脉粥样硬化进程的加速发展,进而增加大动脉粥样硬化性(LAA)卒中风险。同时,TMAO可能通过诱导心脏纤维化、房颤易感性和血栓形成参与心源性栓塞(CE)的病理过程,而在小动脉闭塞性(SAO)卒中中,则可能通过影响糖脂代谢加重小血管病变。尽管已有研究提出通过饮食、益生菌、抗菌药物及他汀类药物等方式降低TMAO水平,但这些干预措施的临床效果尚未完全明确,特别是TMAO对抗血小板药物疗效的影响,目前尚未有定论,仍存在广泛争议。未来的研究应进一步探讨TMAO与卒中亚型的因果关系,评估其临床干预潜力,以期优化缺血性脑卒中的防治策略。 展开更多
关键词 TMAO 缺血性脑卒中 TOAST分型 肠道菌群 治疗策略
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Establishment of FAP-overexpressing Cells for FAP-targeted Theranostics 认领 引用
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作者 Hui-ru JIAN Wen-hao NIU +6 位作者 Zhuo-shuo XU Jia-xu ZHU Xin PAN Yi-rui ZHANG Ping LEI Fa-qing HUANG Yong HE 《Current Medical Science》 SCIE CAS 2023年第3期623-630,共8页
Objective Fibroblast activation protein(FAP)has been widely studied and exploited for its clinical applications.One of the difficulties in interpreting reports of FAP-targeted theranostics is due to the lack of accura... Objective Fibroblast activation protein(FAP)has been widely studied and exploited for its clinical applications.One of the difficulties in interpreting reports of FAP-targeted theranostics is due to the lack of accurate controls,making the results less specific and less confirmative.This study aimed to establish a pair of cell lines,in which one highly expresses FAP(HT1080-hFAP)and the other has no detectable FAP(HT1080-vec)as control,to accurately evaluate the specificity of the FAP-targeted theranostics in vitro and in vivo.Methods The cell lines of the experimental group(HT1080-hFAP)and no-load group(HT1080-vec)were obtained by molecular construction of the recombinant plasmid pIRES-hFAP.The expression of hFAP in HT1080 cells was detected by PCR,Western blotting and flow cytometry.CCK-8,Matrigel transwell invasion assay,scratch test,flow cytometry and immunofluorescence were used to verify the physiological function of FAP.The activities of human dipeptidyl peptidase(DPP)and human endopeptidase(EP)were detected by ELISA in HT1080-hFAP cells.PET imaging was performed in bilateral tumor-bearing nude mice models to evaluate the specificity of FAP.Results RT-PCR and Western blotting demonstrated the mRNA and protein expression of hFAP in HT1080-hFAP cells but not in HT1080-vec cells.Flow cytometry confirmed that nearly 95%of the HT1080-hFAP cells were FAP positive.The engineered hFAP on HT1080 cells had its ability to retain enzymatic activities and a variety of biological functions,including internalization,proliferation-,migration-,and invasion-promoting activities.The HT1080-hFAP xenografted tumors in nude mice bound and took up68GA-FAPI-04 with superior selectivity.High image contrast and tumor-organ ratio were obtained by PET imaging.The HT1080-hFAP tumor retained the radiotracer for at least 60 min.Conclusion This pair of HT1080 cell lines was successfully established,making it feasible for accurate evaluation and visualization of therapeutic and diagnostic agents targeting the hFAP. 展开更多
关键词 fibroblast activation protein 68GA-FAPI-04 reporter gene positron emission computed tomography image
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加热非燃烧卷烟降温材料用聚乳酸及其复合物的性能 认领 引用 被引量：14
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作者 王东岳 雷萍 +3 位作者 杨仁裕 何毅 袁明龙 李宏利 《高分子材料科学与工程》 EI CAS CSCD 北大核心 2020年第4期21-28,共8页
高强度聚乳酸和熔融共混的无机纳米粒子氮化硼(BN)/聚乳酸(PLA)复合物通过溶剂流延法制备成薄膜材料,并与现有新型卷烟降温段材料进行对比。X射线衍射结果表明,BN粒子添加后结晶度提升4%~11%;热重分析、差示扫描量热分析的结果显示,复... 高强度聚乳酸和熔融共混的无机纳米粒子氮化硼(BN)/聚乳酸(PLA)复合物通过溶剂流延法制备成薄膜材料,并与现有新型卷烟降温段材料进行对比。X射线衍射结果表明,BN粒子添加后结晶度提升4%~11%;热重分析、差示扫描量热分析的结果显示,复合材料的熔融温度提升16~18℃,热分解温度提升1~20℃;从力学性能测试与动态力学热分析的结果中得出,复合材料的力学性能显著提升,韧性增大130%;降温测试结果显示,复合材料的降温性能提升1%~30%。当BN添加量为2%时,复合材料作为新型卷烟降温材料的综合性能最佳。 展开更多
关键词 聚乳酸 氮化硼 改性 降温性能
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阿替普酶静脉溶栓治疗不同程度脑白质高信号的急性脑梗死患者预后的影响因素分析 认领 引用 被引量：19
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作者 刘雯 陈国芳 +8 位作者 梁艺馨 刘薇薇 平蕾 周生奎 刘雷婧 田永芳 徐辉 王磊 王琛 《中国脑血管病杂志》 CAS CSCD 北大核心 2019年第10期508-513,共6页
目的探讨阿替普酶静脉溶栓治疗合并不同程度脑白质高信号(WMH)的急性脑梗死预后的影响因素。方法回顾性连续纳入2016年9月至2019年1月徐州市中心医院神经内科住院的使用阿替普酶静脉溶栓治疗的合并不同程度WMH的急性脑梗死患者326例,采... 目的探讨阿替普酶静脉溶栓治疗合并不同程度脑白质高信号(WMH)的急性脑梗死预后的影响因素。方法回顾性连续纳入2016年9月至2019年1月徐州市中心医院神经内科住院的使用阿替普酶静脉溶栓治疗的合并不同程度WMH的急性脑梗死患者326例,采用Fazekas量表评估WMH程度,美国国立卫生研究院卒中量表(NIHSS)评估患者溶栓前神经功能缺损情况,改良Rankin量表(mRS)评估90d预后,根据mRS评分将患者分为预后良好组(mRS0~2分,247例)和预后不良组(mRS>2分,79例),比较两组患者的年龄、性别、既往卒中相关危险因素、相关生化指标及溶栓前NIHSS评分,将年龄、心房颤动、冠状动脉粥样硬化性心脏病、WMH、溶栓前NIHSS评分纳入二元多因素Logistic回归分析,探讨影响阿替普酶静脉溶栓治疗合并不同程度WMH的急性脑梗死患者临床预后不良的危险因素。结果预后良好组与预后不良组年龄[(65±12)岁比(70±12)岁,t=-2.984,P=0.003)],既往心房颤动史[10.1%(25/247)比21.5%(17/79),χ^2=6.928,P=0.008]、冠状动脉粥样硬化性心脏病史[8.1%(20/247)比21.5%(17/79),χ^2=10.717,P=0.001]、溶栓前NIHSS评分[6(4,10)比12(8,19)分,Z=-7.183,P<0.01]及WMH[无WMH、轻度WMH、中度WMH、重度WMH:5.3%(13/247)、55.9%(138/247)、24.3%(60/247)、14.6%(36/247)比0、36.7%(29/79)、34.2%(27/79)、29.1%(23/79),χ^2=17.631,P<0.01]差异均有统计学意义。二元多因素Logistic回归分析显示,中、重度WMH(OR=2.145,95%CI1.17~3.49,P=0.014)及溶栓前NIHSS评分≥9分(OR=1.131,95%CI1.08~1.18,P<0.01)是影响阿替普酶静脉溶栓治疗合并不同程度WMH的急性脑梗死患者预后不良的独立危险因素。结论中、重度WMH和溶栓前NIHSS评分是阿替普酶静脉溶栓治疗不同程度WMH的急性脑梗死患者临床预后不良的独立危险因素。 展开更多
关键词 脑白质高信号 静脉溶栓 预后
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阿加曲班联合阿司匹林及氯吡格雷治疗对急性脑梗死患者神经功能缺损及生活能力的影响 认领 引用 被引量：38
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作者 平蕾 刘雷婧 +1 位作者 刘薇薇 李晓宾 《神经疾病与精神卫生》 2018年第8期595-597,共3页
目的 评价阿加曲班联合阿司匹林及氯吡格雷双联抗血小板治疗急性脑梗死的临床疗效,探讨治疗急性脑梗死积极有效的方法.方法 将徐州市中心医院神经内科的急性脑梗死住院患者80例随机分为两组,即治疗组（40例）和对照组（40例）.治疗组同... 目的 评价阿加曲班联合阿司匹林及氯吡格雷双联抗血小板治疗急性脑梗死的临床疗效,探讨治疗急性脑梗死积极有效的方法.方法 将徐州市中心医院神经内科的急性脑梗死住院患者80例随机分为两组,即治疗组（40例）和对照组（40例）.治疗组同时给予阿加曲班及阿司匹林、氯吡格雷治疗;对照组不用阿加曲班,其他治疗同治疗组.两组患者在治疗前与治疗后7 d、14 d进行美国国立卫生院卒神经功能缺损（NIHSS）评分,治疗前与治疗后14 d进行日常生活能力（ADL）评分,以评价治疗效果.结果 治疗后14 d治疗组NIHSS评分明显低于对照组（P〈0.05）,ADL评分明显高于对照组（均P〈0.01）.两组均无明显不良反应.结论 急性进展性脑梗死应用阿加曲班联合阿司匹林、氯吡格雷治疗安全有效,较阿司匹林及氯吡格雷治疗有效,值得临床推广. 展开更多
关键词 脑梗死 阿司匹林 阿加曲班 氯吡格雷 神经功能缺损 日常生活能力
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基于多层叠加传输的超奈奎斯特传输方案 认领 引用 被引量：4
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作者 李双洋 平磊 +1 位作者 白宝明 马啸 《通信学报》 EI CSCD 北大核心 2017年第9期86-94,共9页
超奈奎斯特(FTN,faster-than-Nyquist)传输技术作为一种能够有效提高系统频谱利用率的手段,受到了广泛的关注。针对该技术在信号检测中所具有的检测复杂度高的缺陷,提出一种基于多层叠加传输的FTN传输系统。通过理论推导给出了其每层最... 超奈奎斯特(FTN,faster-than-Nyquist)传输技术作为一种能够有效提高系统频谱利用率的手段,受到了广泛的关注。针对该技术在信号检测中所具有的检测复杂度高的缺陷,提出一种基于多层叠加传输的FTN传输系统。通过理论推导给出了其每层最佳编码方案的选择依据,并通过仿真证明在每一层码率与功率同时变化的性能优于仅功率发生变化的情形,仿真结果同时表明在脉冲成形函数的滚降系数不为0的条件下,该系统的性能优于级联了更大星座的正交传输系统的性能。 展开更多
关键词 超奈奎斯特传输 多层结构 逐次干扰抵消 叠加编码 检测算法
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焦岗湖国家湿地公园鸟类群落多样性及其季节动态 认领 引用 被引量：11
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作者 平磊 周立志 《生物学杂志》 CAS CSCD 北大核心 2018年第1期68-72,共5页
2014年10月—2015年9月,采用样线和样点法对安徽淮南焦岗湖国家湿地公园鸟类资源进行了调查,分析鸟类群落多样性及其季节变化。在湿地公园内共记录到鸟类15目37科96种,留鸟41种(42.7%),冬候鸟25种(26.0%),夏候鸟21种(21.9%),旅鸟9种(9.... 2014年10月—2015年9月,采用样线和样点法对安徽淮南焦岗湖国家湿地公园鸟类资源进行了调查,分析鸟类群落多样性及其季节变化。在湿地公园内共记录到鸟类15目37科96种,留鸟41种(42.7%),冬候鸟25种(26.0%),夏候鸟21种(21.9%),旅鸟9种(9.4%)。鸟类区系以古北种和东洋种为主,兼有广布种。Shannon-Wiener指数以保护区最高(1.99),观光区最低(1.27),全年鸟类多样性为夏季>春季>秋季>冬季。旅游区与观光区相似性最低(0.427),防护区与观光区相似性最高(0.726)。同时,对湿地公园的后续建设及管理方式提出建议。 展开更多
关键词 湿地公园 鸟类多样性 季节动态
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基于颅脑CT灌注成像筛选的急性基底动脉闭塞性脑梗死的血管内再通治疗临床研究 认领 引用 被引量：16
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作者 张清清 傅聪 +6 位作者 傅新民 马庆防 张洋 陆俊杰 李峤 平蕾 施洪超 《生物医学工程与临床》 CAS 2021年第2期155-159,共5页
目的基于颅脑CT灌注成像(CTP)筛选的急性基底动脉闭塞性脑梗死血管内再通治疗的临床安全性及治疗效果。方法选择发病12 h内、责任血管椎基底动脉完全闭塞且住院的急性后循环脑梗死患者60例,其中男性40例,女性20例;年龄39~94岁,平均年龄6... 目的基于颅脑CT灌注成像(CTP)筛选的急性基底动脉闭塞性脑梗死血管内再通治疗的临床安全性及治疗效果。方法选择发病12 h内、责任血管椎基底动脉完全闭塞且住院的急性后循环脑梗死患者60例,其中男性40例,女性20例;年龄39~94岁,平均年龄63.32岁。行一站式颅脑CT平扫和CTP检查。采用简单随机抽样法,分为2组。治疗组30例,采用血管内治疗联合标准脑梗死药物治疗;对照组30例,采用标准脑梗死药物治疗。采用脑梗死溶栓(TICI)分级评估两组血管再通、颅脑CT平扫评估症状性出血,用颅脑CT血管造影或磁共振血管造影评估再闭塞情况;采用90 d改良Rankin量表(m RS)对比两组临床预后和90 d死亡率。结果60例基底动脉完全闭塞处于梗死前期缺血的程度为Ⅰ~Ⅱ1期。其中治疗组Ⅰ1期11例,Ⅰ2期7例,Ⅱ1期12例;对照组Ⅰ1期10例,Ⅰ2期6例,Ⅱ1期14例。治疗组术后血流TICI分级2b或3级的比例高于对照组[93.33%(28/30)vs 6.67%(2/30);P<0.01]。治疗组预后良好率高于对照组(60.00%vs 13.33%;P<0.01)。治疗组90 d死亡率低于对照组(26.67%vs 66.67%;P<0.01)。治疗组症状性脑出血发生率虽然高于对照组(10.00%vs 6.67%),但差异无统计学意义(P=0.46)。治疗组死亡率低于对照组(26.67%vs66.67%;P<0.01)。结论急性后循环脑梗死患者在发病12 h内,经一站式颅脑CT平扫和CTP检查筛选处于梗死前Ⅰ~Ⅱ1期,采用血管内治疗技术和标准脑梗死药物治疗,临床症状改善显著,预后良好。 展开更多
关键词 急性脑梗死 基底动脉闭塞 脑血栓取出装置 血栓抽吸系统 颅脑CT灌注成像
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超高层建筑层间消防隔断设计与研究 认领 引用 被引量：4
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作者 袁青 邬红茹 +1 位作者 彭磊 刘娜 《建筑技艺（中英文）》 2019年第6期126-127,共2页
对于高度超过250m的超高层建筑,设计可靠耐用的层间防火分隔是幕墙设计的重要工作。通过多类型方案的对比,选择最合适项目的系统,采用科学手段进行分析研究,再辅以实体试验验证,保证建筑的使用安全,也为超高层建筑的层间防火设计找到突... 对于高度超过250m的超高层建筑,设计可靠耐用的层间防火分隔是幕墙设计的重要工作。通过多类型方案的对比,选择最合适项目的系统,采用科学手段进行分析研究,再辅以实体试验验证,保证建筑的使用安全,也为超高层建筑的层间防火设计找到突破点。 展开更多
关键词 层间防火分隔 超高层消防性能化试验 防火性能 建筑幕墙消防性能化试验
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