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Transjugular intrahepatic portosystemic shunt improves survival in anticoagulation-resistant hepatic sinusoidal obstructive syndrome patients:A multicenter retrospective study 认领 引用
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作者 Jing-Jing Tu Han Zhang +11 位作者 De-Run Kong Yan-Hong Feng Yue-Cheng Yu Tai-Shun Li Feng Zhang Wei Zhang Hui Xu Qin Yin Lei Wang Ming Zhang Jiang-Qiang Xiao Yu-Zheng Zhuge 《World Journal of Hepatology》 2026年第2期167-177,共11页
BACKGROUND Anticoagulation therapy is recommended during the acute or subacute stage for patients with pyrrolizidine alkaloid-hepatic sinusoidal obstruction syndrome(PAHSOS).Transjugular intrahepatic portosystemic shu... BACKGROUND Anticoagulation therapy is recommended during the acute or subacute stage for patients with pyrrolizidine alkaloid-hepatic sinusoidal obstruction syndrome(PAHSOS).Transjugular intrahepatic portosystemic shunts(TIPS)is suggested as a step-up treatment when patients do not respond to anticoagulants.However,more evidence of the efficacy of TIPS is needed.AIM To evaluate the effect of TIPS in these patients.METHODS Between January 2013 and September 2020,we retrospectively enrolled patients with PA-HSOS who did not respond to short-term anticoagulation therapy at four hospitals.The patients were divided into a TIPS treatment group and an anticoagulation therapy group.Baseline information and clinical characteristics were collected and recorded.Survival in both groups was the primary study endpoint and the risk factors for patient death were further analyzed.RESULTS A total of 99 patients were enrolled according to the inclusion and exclusion criteria(63 in the TIPS group and 36 in the anticoagulation therapy group).There were 17 deaths during the median follow-up time of 32.5 months.Treatment,age,aspartate aminotransferase,and serum total bilirubin were independent risk factors for predicting death.The survival of patients in the TIPS group was significantly greater than that of patients in the continuing anticoagulation therapy group(P=0.028).When stratified by the Drum-Tower Severity Scoring,in the TIPS group,mild and moderate patients had better outcomes than severe patients.CONCLUSION TIPS can improve the transplant-free survival rate in patients with PA-HSOS who do not respond to short-term anticoagulation therapy,and patients with mild and moderate Drum-Tower Severity Scoring grade can benefit from TIPS. 展开更多
关键词 Hepatic sinusoidal obstruction syndrome Hepatic veno-occlusive disease No response to anticoagulation therapy Gynura segetum Pyrrolizidine alkaloids Transjugular intrahepatic portosystemic shunts Transplant-free survival
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Recent advances on asymmetric reduction via dynamic kinetic resolution 认领 引用 被引量：1
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作者 Ao Zhou Mostafa M.K.Amer Qin Yin 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第5期24-51,共28页
Asymmetric reduction of unsaturated compounds via dynamic kinetic resolution(DKR)has significantly enhanced the efficiency and selectivity of synthesizing enantiomerically pure compounds from racemic substrates.This a... Asymmetric reduction of unsaturated compounds via dynamic kinetic resolution(DKR)has significantly enhanced the efficiency and selectivity of synthesizing enantiomerically pure compounds from racemic substrates.This approach combines the simultaneous racemization of substrates with enantioselective reduction,enabling quantitative yields and high enantiomeric excess.In the past several years,remarkable advances in this field have been achieved,ranging from the development of innovative catalytic systems,novel synthetic strategies,expansion of substrate scope,deeper mechanistic understanding,and their applications.These advancements offer alternative and efficient methods in the asymmetric synthesis of chiral molecules bearing multiple consecutive stereogenic centers,particularly beneficial for the synthesis of natural products or chiral intermediates in pharmaceuticals and fine chemicals.In this review,we summarize the recent advances during the last several years according to the substrate types in this powerful and productive field,with an emphasis on the development of new catalytic systems and the insight into the DKR process. 展开更多
关键词 Dynamic kinetic resolution Asymmetric reduction Asymmetrichydrogenation Transfer hydrogenation Drug synthesis
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环境监测中氰化物测定方法的研究进展 认领 引用
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作者 杨玉春 刘贵有 +2 位作者 尹旭山 秦颖 张朝容 《云南化工》 CAS 2026年第6期16-19,共4页
综述了环境监测中氰化物测定的容量滴定、分光光度、连续流动分析、流动注射分析、离子选择电极、光纤传感、离子色谱、气相色谱、原子吸收和极谱法等常用方法与应用现状,有利于推动氰化物检测技术的标准化、精准化与实用化,为环境监测... 综述了环境监测中氰化物测定的容量滴定、分光光度、连续流动分析、流动注射分析、离子选择电极、光纤传感、离子色谱、气相色谱、原子吸收和极谱法等常用方法与应用现状,有利于推动氰化物检测技术的标准化、精准化与实用化,为环境监测选择分析方法作参考。 展开更多
关键词 氰化物 仪器分析 环境监测
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Imrecoxib alleviates hepatic damage in type 2 diabetic rats by modulating PI3K/ AKT/NF-κB signaling 认领 引用
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作者 Xue-He Sheng Meng-Xue Liu +2 位作者 Lu-Lu Zhou Ting-Ting Luo Qin Yin 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2025年第12期524-532,共9页
Objective:To investigate the influence and underlying mechanisms of imrecoxib on liver damage in rats with type 2 diabetes mellitus(T2DM).Methods:A rat model of T2DM was established by a high-fat diet and streptozotoc... Objective:To investigate the influence and underlying mechanisms of imrecoxib on liver damage in rats with type 2 diabetes mellitus(T2DM).Methods:A rat model of T2DM was established by a high-fat diet and streptozotocin administration.Rats were then treated with imrecoxib 10,20,or 40 mg/kg for 5 weeks.Body weight and fasting blood glucose levels were measured.The analysis included serum liver function,blood lipid profiles,and the levels of inflammatory factors in the rats.Liver tissue histology was evaluated using hematoxylin and eosin staining.Western blotting was conducted to measure the liver expression of proteins such as AKT,PI3K,NF-κB,p-AKT,p-PI3K,and p-NF-κB.Results:Rats treated with imrecoxib showed a greater weight gain compared to untreated diabetic rats.Compared to untreated diabetic rats,imrecoxib at all three doses reduced alanine aminotransferase,aspartate aminotransferase,triglycerides,cholesterol,tumor necrosis factor-α,interleukin(IL)-6,and IL-1β,and significantly increased the levels of IL-10 and IL-4.In imrecoxib-treated rats,the expression levels of AKT,PI3K,p-AKT,and p-PI3K were higher in comparison to the diabetes group,whereas the expression of p-NF-κB was lower.Conclusions:Imrecoxib could alleviate hepatic damage in T2DM rats by modulating PI3K/AKT/NF-κB signaling. 展开更多
关键词 Type 2 diabetes Liver injury Imrecoxib Inflammatory response PI3K/AKT/NF-κB signaling pathway
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1-MCP结合SO2间隔熏蒸处理对采后西梅品质及相关酶活性的影响 认领 引用
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作者 赵美玉 秦银 +5 位作者 翟梦远 籍星旭 张世豪 刘晶玉 孙腾飞 李学文 《食品与发酵工业》 EI CAS CSCD 北大核心 2026年第7期328-335,共8页
该实验以“法兰西”西梅为试验材料,采用1-MCP结合SO2熏蒸处理,研究其对西梅贮藏品质的影响,为研发西梅贮运保鲜技术提供理论支撑。果实预冷后,分成对照组、1μL/L 1-MCP组、150μL/L SO2间隔熏蒸组、1μL/L 1-MCP结合150μL/L SO... 该实验以“法兰西”西梅为试验材料,采用1-MCP结合SO2熏蒸处理,研究其对西梅贮藏品质的影响,为研发西梅贮运保鲜技术提供理论支撑。果实预冷后,分成对照组、1μL/L 1-MCP组、150μL/L SO2间隔熏蒸组、1μL/L 1-MCP结合150μL/L SO2间隔熏蒸组,处理后贮藏于-1~1℃保鲜库内,定期取样测定果实硬度、可溶性固形物含量、可滴定酸含量、细胞膜渗透率、呼吸速率、果皮色差值、丙二醛含量、总酚含量、类黄酮含量、苯丙氨酸解氨酶活性、几丁质酶活性的变化。结果表明:与其他处理组相比,1-MCP结合SO2间隔熏蒸组能够在一定的程度上延缓硬度、可溶性固形物、可滴定酸含量、丙二醛含量的下降,有效抑制细胞膜渗透率升高,降低呼吸强度。贮藏120 d时,1-MCP结合SO2间隔熏蒸组硬度是对照组的1.99倍,较1-MCP处理组、SO2间隔熏蒸处理组分别提高17.1%、99.2%;可溶性固形物含量较对照组提高15.1%,可滴定酸含量提高42.0%,细胞膜渗透率减少24.3%,丙二醛含量减少22.6%,显著提高了苯丙氨酸解氨酶、几丁质酶活性,且SO2残留量低,符合国家安全标准。 展开更多
关键词 西梅 SO2 1-MCP 间隔熏蒸 果实品质 酶活性
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一种非电传爆系统输出接头延期结构设计与实现 认领 引用
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作者 孙晓霞 张亮亮 +4 位作者 关文超 段卜仁 汪宇晨 秦崟 徐秀娟 《火工品》 CAS CSCD 北大核心 2026年第1期61-65,共5页
针对某火工系统中传爆组件1路延期输出的需求,设计了1种输出接头延期结构,在可靠起爆与传爆的同时实现高精度延期。通过药剂选择与传火传爆序列设计、消爆腔与传火孔设计以及密闭式燃烧3个方面的匹配设计,实现了限制性导爆索对输出接头... 针对某火工系统中传爆组件1路延期输出的需求,设计了1种输出接头延期结构,在可靠起爆与传爆的同时实现高精度延期。通过药剂选择与传火传爆序列设计、消爆腔与传火孔设计以及密闭式燃烧3个方面的匹配设计,实现了限制性导爆索对输出接头的非接触起爆,并达到了(80±25) ms的延期时间要求。采用雷管直接起爆限制性导爆索时,170 mm长的限制性导爆索起爆输出接头形成的半敞开燃烧环境会导致延期时间偏长且精度较差;而使用600 mm长的限制性导爆索起爆输出接头时测试得到的延期时间与实际使用基本相当,表明可以使用较长限制性导爆索对延期输出接头的燃烧环境进行约束。 展开更多
关键词 非电传爆系统 输出接头 延期结构 限制性导爆索
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动物模型中人工miRNA的设计优化与应用研究进展 认领 引用
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作者 高良辰 黄洲一 +4 位作者 梁兆伦 覃毅 李鑫鑫 李辉 王健 《中国畜牧杂志》 CAS CSCD 北大核心 2026年第7期78-86,共9页
近些年来,RNA干扰(RNAi)技术在诸多领域的应用愈发广泛。microRNA(miRNAs)是一类存在于真核生物中的非编码小分子RNA,以序列特异性方式在转录后水平参与基因表达的调节,是真核生物细胞内发挥RNA干扰的天然分子。人工microRNA(miRNA)具... 近些年来,RNA干扰(RNAi)技术在诸多领域的应用愈发广泛。microRNA(miRNAs)是一类存在于真核生物中的非编码小分子RNA,以序列特异性方式在转录后水平参与基因表达的调节,是真核生物细胞内发挥RNA干扰的天然分子。人工microRNA(miRNA)具有高度可编程性支持精准靶向致病基因,沉默效率大大提高且脱靶率较传统RNAi明显降低,显著提升治疗安全性,低免疫原性减少宿主排斥反应;通过时空特异性表达设计,能实现组织或发育阶段选择性基因沉默,兼具治疗精准度与可控性。本文总结了动物人工miRNA的研究现状,包括人工miRNA的设计和构建原理,对靶向序列选择、结构优化和传递载体的选择等关键因素进行汇总解析,并总结人工miRNA在基因调控中的应用,旨在强调人工miRNA作为靶向调控基因的巨大潜力以及其在提高调控效果和减少副作用方面的优势。 展开更多
关键词 RNAi 人工miRNA 靶向调控 基因治疗
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Effects of moxibustion at different temperature on wound healing and apoptosis in rats with pressure ulcer based on PI3K/AKT/mTOR signal pathway 认领 引用 被引量：2
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作者 Hong PAN Ying-Bo XI +3 位作者 Jin DING Qin YIN Hui-Qin XUE Hai-Yu YUE 《World Journal of Acupuncture-Moxibustion》 CAS CSCD 2025年第2期125-134,共10页
Objective To investigate the effects of moxibustion on wound healing and evaluate whether the efficacy of moxibustion at different temperatures varies.Additionally,to explore the mechanism by which moxibustion regulat... Objective To investigate the effects of moxibustion on wound healing and evaluate whether the efficacy of moxibustion at different temperatures varies.Additionally,to explore the mechanism by which moxibustion regulates the phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/mammalian rapamycin target protein(mTOR)signaling pathway on wound healing and cell apoptosis.Methods A total of 90 SPF-grade SD rats were randomly divided into six groups(15 rats per group):control group,model group,recombinant bovine basic fibroblast growth factor gel(rb-bFGF)group,moxibustion group A[temperature(42±1)℃],moxibustion group B[temperature(45±1)℃],and moxibustion group C[temperature(48±1)℃].Except the control group,the interventions were conducted in the other groups with pressure ulcer induced by ischemiaeperfusion injury.In the control group,povidone-iodine was administered at the knee joint.In the model group,after povidone-iodine applied at the pressure ulcer,petroleum jelly gauze was bandaged.In the rb-bFGF group,after povidone-iodine applied at the pressure ulcer,rb-bFGF was smeared and petroleum jelly gauze was bandaged.In the moxibustion group A,the suspending moxibustion with moxa stick was delivered 3 cm to 5 cm above the ulcer.The paperless temperature recorder probe was placed on the wound surface where moxibustion was delivered,and the real-time temperature was monitored and adjusted,kept at(42±1)℃.The moxibustion temperature was kept at(45±1)℃ in the moxibustion group B,and(48±1)℃ in the moxibustion group C.The intervention lasted 14 days in each group.The wound healing rates were compared on the 3,5,7 and 14 days after the first intervention among the 6 groups.After 14-day intervention respectively,the histopathological changes were observed with HE staining,apoptosis was detected with TUNEL method and flow cytometry;VEGF-A protein expression determined with immunohistochemistry;the contents of Interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and transforming growth factor-β(TGF-β)in serum with ELISA,and PI3K/AKT/mTOR related protein and mRNA expression was with Western blotting and qRT-PCR in wound tissues of each group.Results Regarding the intervention effects,(1)compared with the control group,the model group showed significant inflammatory infiltration in wound tissues,higher levels of cell apoptosis,and elevated serum levels of IL-6,TNF-αand TGF-β(P<0.05);(2)compared with the model group,the rb-bFGF group and 3 moxibustion groups showed higher wound healing rates(P<0.05),reduced inflammatory infiltration in the wound tissues,lower levels of cell apoptosis,and decreased serum levels of IL-6,TNF-αand TGF-β(P<0.05).Among the moxibustion groups,group C showed significantly better results than group A(P<0.01).Regarding the mechanism,(1)compared with the control group,the model group exhibited significantly higher protein and mRNA expression levels of PI3K/AKT/mTOR signal pathway components(P<0.05);(2)compared with the model group,the rb-bFGF group and 3 moxibustion groups showed lower protein and mRNA expression levels of PI3K/AKT/mTOR signal pathway components(P<0.05).Among the moxibustion groups,group C showed significantly higher expression levels than group A(P<0.01).Conclusion Moxibustion significantly promotes wound healing,with high-temperature moxibustion being more effective than low-temperature moxibustion in reducing the expression of inflammatory factors and cell apoptosis,thereby improving wound healing rates.It is presented that the higher moxibustion temperature,the higher wound healing rate,which may be associated with the regulation of PI3K/AKT/mTOR signal pathway with moxibustion. 展开更多
关键词 Pressure ulcer Moxibustion warming PI3K/AKT/mTOR Apoptosis Inflammatory factor
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雷火灸联合乳房按摩在母乳喂养咨询门诊中的应用效果 认领 引用
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作者 蒙晓慧 黄秋红 +4 位作者 温美灵 覃尹 韦小连 刘菁菁 罗璇璇 《妇儿健康导刊》 2026年第7期134-138,共5页
目的探究雷火灸联合乳房按摩在母乳喂养咨询门诊中的应用效果,为产后母乳喂养困难提供规范化护理干预方案。方法采用随机对照试验设计,选取2022年7月至2023年6月广西医科大学第二附属医院母乳喂养咨询门诊的153例本院分娩产后42 d内复... 目的探究雷火灸联合乳房按摩在母乳喂养咨询门诊中的应用效果,为产后母乳喂养困难提供规范化护理干预方案。方法采用随机对照试验设计,选取2022年7月至2023年6月广西医科大学第二附属医院母乳喂养咨询门诊的153例本院分娩产后42 d内复诊且存在哺乳问题的产妇,按随机数字表法分为观察组(76例)和对照组(77例)。两组产妇根据首次复诊时间开始启动干预,持续7 d,对照组采用常规乳房按摩,观察组采用雷火灸联合乳房按摩。比较两组乳腺疏通情况、72 h泌乳评分、单次哺乳量、乳房胀痛评分及6个月母乳喂养持续率。结果观察组乳腺通畅情况优于对照组,差异有统计学意义(P<0.05)。观察组72 h泌乳评分[(2.82±0.28)分]、单次哺乳量[(178.50±31.20)ml/次]、6个月母乳喂养持续率(89.71%)均高于对照组[(2.08±0.39)分、(142.30±24.80)ml/次、68.12%],乳房胀痛评分[(2.1±0.6)分]低于对照组[(4.7±1.2)分],差异均有统计学意义(P<0.05)。结论雷火灸联合乳房按摩可有效改善母乳喂养咨询门诊产妇的哺乳结局,值得临床推广。 展开更多
关键词 雷火灸 乳房按摩 母乳喂养 母乳喂养咨询门诊 泌乳量
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益气养阴解毒方对Lewis肺癌小鼠的免疫调节及抗肿瘤作用 认领 引用 被引量：4
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作者 刘莲芳 卢子涵 +3 位作者 胡霞 周勤峰 秦垠 梅宇波 《南京中医药大学学报》 CAS CSCD 北大核心 2025年第1期95-101,共7页
目的探索益气养阴解毒方对Lewis肺癌小鼠的抗肿瘤作用及其对免疫调节的影响。方法腋下皮下注射Lewis肺癌细胞构建Lewis肺癌小鼠模型,分为模型组、低剂量组、中剂量组、高剂量组,并计算肿瘤体积、抑瘤率和生存率。分别使用HE染色,TUNEL... 目的探索益气养阴解毒方对Lewis肺癌小鼠的抗肿瘤作用及其对免疫调节的影响。方法腋下皮下注射Lewis肺癌细胞构建Lewis肺癌小鼠模型,分为模型组、低剂量组、中剂量组、高剂量组,并计算肿瘤体积、抑瘤率和生存率。分别使用HE染色,TUNEL试验和彗星实验检测肿瘤细胞凋亡和DNA损伤。ELISA法检测IFN-γ、IL-2、TNF-α的表达水平。免疫荧光、流式细胞术检测CD8+T、CD8+/CD4+T、PD-1+、IFN-γ+、CD28+细胞占比。Western blot法检测PD-1、CD69、CD28的蛋白水平。结果益气养阴解毒方具有抗肿瘤,延长生存期的作用,还可促进肿瘤细胞凋亡并加剧肿瘤细胞DNA损伤。益气养阴解毒方促进了IFN-γ、IL-2、TNF-α的表达,提高了CD8+T、CD8+/CD4+T、IFN-γ+、CD28+细胞占比,并抑制了PD-1+细胞占比和蛋白表达,CD69、CD28的蛋白水平显著上升。结论益气养阴解毒方可以抑制肿瘤发展,其对免疫功能的调节是其抗肿瘤作用的潜在作用机制。 展开更多
关键词 益气养阴解毒方 非小细胞肺癌 免疫调节 PD-1
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Research Progress on Male Sterility in Dzo(Yak-Cattle Hybrid) 认领 引用
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作者 Qin YIN Xiaoyun CHEN Xiaodong DENG 《Asian Agricultural Research》 2025年第10期42-44,共3页
Male dzo from the F1 to F3 generations are sterile,which impedes the utilization of hybrid vigor in dzo and constrains the development of plateau animal husbandry in China.The underlying mechanism of this phenomenon h... Male dzo from the F1 to F3 generations are sterile,which impedes the utilization of hybrid vigor in dzo and constrains the development of plateau animal husbandry in China.The underlying mechanism of this phenomenon has long been a focal point in yak crossbreeding improvement research.This review summarizes the mechanisms underlying male sterility in dzo from histological,physiological,and multi-omics perspectives,providing research directions for further exploration of the mechanisms of male sterility in dzo. 展开更多
关键词 Dzo Testis Male sterility Multi-omics sequencing
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Analysis of Clinical Application Effect of Autologous Fat Granule Transplantation in Facial Depression Plastic Surgery 认领 引用
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作者 Hangli Wu Qin Yin Wenjie Gao 《Journal of Clinical and Nursing Research》 2025年第8期140-146,共7页
Objective:To explore the clinical application effect of autologous fat granule transplantation in facial depression plastic surgery.Methods:A total of 98 patients with facial depression admitted to the plastic surgery... Objective:To explore the clinical application effect of autologous fat granule transplantation in facial depression plastic surgery.Methods:A total of 98 patients with facial depression admitted to the plastic surgery department of our hospital from January 2021 to December 2023 were selected and divided into observation group(49 cases)and control group(49 cases)according to the random number table method.The observation group was treated with autologous fat granule transplantation,while the control group was treated with hyaluronic acid filling.The total effective rate of treatment,incidence of postoperative complications,improvement indicators of facial morphology(depth of depression,symmetry),and effect maintenance rate after 6 months of follow-up were compared between the two groups.Results:The total effective rate of treatment in the observation group was 93.88%(46/49),which was significantly higher than that in the control group(79.59%,39/49)(P<0.05).The incidence of postoperative complications in the observation group was 6.12%(3/49),which was lower than that in the control group(20.41%,10/49)(P<0.05).One month after surgery,the depth of depression(1.23±0.31 mm)and symmetry(1.02±0.15 points)in the observation group were better than those in the control group(P<0.05).After 6 months of follow-up,the effect maintenance rate in the observation group was 89.80%(44/49),which was significantly higher than that in the control group(67.35%,33/49)(P<0.05).Conclusion:Autologous fat granule transplantation for the treatment of facial depression can significantly improve facial morphology,enhance treatment effect and patient satisfaction,reduce the incidence of complications,and maintain a more durable effect.It is a clinically preferred facial depression plastic surgery solution. 展开更多
关键词 Autologous fat granule transplantation Facial depression Plastic surgery Clinical effect Hyaluronic acid filling
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Improving the energy release characteristics of PTFE/Al by doping magnesium hydride 认领 引用 被引量：12
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作者 Jia-xiang Wu Qiang Liu +6 位作者 Bin Feng Qin Yin Yu-chun Li Shuang-zhang Wu Zhong-shen Yu Jun-yi Huang Xin-xin Ren 《Defence Technology（防务技术）》 SCIE EI CAS CSCD 2022年第2期219-228,共10页
Magnesium hydride(MgH2)was doped into PTFE/Al to improve the energy release characteristics of the material system and strive for better application in military engineering.Five types of PTFE/Al/MgH2 reactive material... Magnesium hydride(MgH2)was doped into PTFE/Al to improve the energy release characteristics of the material system and strive for better application in military engineering.Five types of PTFE/Al/MgH2 reactive materials with different MgH2 content were prepared by molding sintering method.The dynamic mechanical properties of the materials were studied by performing split-Hopkinson pressure bar(SHPB)tests and scanning electron microscope characterizations.The thermal behavior,reaction energy,reaction process and reaction mechanism were systematically investigated by conducting thermogravimetry-differential scanning calorimetry tests,oxygen bomb calorimeter measurements,Xray diffraction and SHPB tests.The results show that MgH2 particles less than 10%content contribute to heightening the dynamic mechanical properties of PTFE/Al system.The product Mg generated by decomposition of MgH2 can not only react with gas phase C2F4þbut also undergo a Grignard-type reaction with condensed PTFE.The reaction energy and ignition threshold of PTFE/Al/MgH2 reactive materials enhance monotonously as MgH2 content rose.With the increase of MgH2 content from 0%to 20%,the reaction time is prolonged as well as the reaction intensity is enhanced dramatically arising from the massive water vapour produced by the reaction between O2 and H2.The gaseous products generated can form a high pressure shortly after the reaction,which helps to elevate the damage effect of the PTFE/Al system. 展开更多
关键词 PTFE/Al/MgH2 Mechanical properties Thermal behavior Reaction energy Ignition threshold
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保加利亚乳杆菌固态发酵多花黄精工艺优化及对其酶解液品质的影响 认领 引用 被引量：3
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作者 廖升宇 唐成林 +3 位作者 覃引 郭太琼 胡娟泽 朱国飞 《食品工业科技》 EI CAS 北大核心 2025年第21期256-265,共10页
为探究保加利亚乳杆菌固态发酵多花黄精工艺优化及发酵前后多花黄精酶解液的品质差异,本研究以接种量、发酵温度和发酵时间为影响因素,以DPPH自由基清除率、总皂苷含量为评价指标,采用单因素结合BoxBehnken响应面试验优化发酵工艺,同时... 为探究保加利亚乳杆菌固态发酵多花黄精工艺优化及发酵前后多花黄精酶解液的品质差异,本研究以接种量、发酵温度和发酵时间为影响因素,以DPPH自由基清除率、总皂苷含量为评价指标,采用单因素结合BoxBehnken响应面试验优化发酵工艺,同时对其抗氧化活性和生物活性物质含量进行检测。结果表明,保加利亚乳杆菌发酵多花黄精的最佳工艺条件为接种量3%、发酵温度38℃、发酵时间49 h,在此条件下,多花黄精酶解液的DPPH自由基清除率为76.76%±1.49%,总皂苷含量为(5.00±0.01)mg/mL。经检测,发酵后多花黄精酶解液的ABTS~+自由基清除率、总抗氧化能力分别为90.10%±0.85%、(20.23±0.98)μmol/mL,总酚、多糖和可溶性固形物含量分别为(93.44±5.46)μg/mL、(26.16±0.03)mg/mL和(6.57±0.05)°Brix,均高于未发酵组。说明多花黄精经保加利亚乳杆菌固态发酵后,其抗氧化活性增强,部分生物活性物质含量得到了提高。 展开更多
关键词 多花黄精 保加利亚乳杆菌 固态发酵 抗氧化活性 生物活性物质
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Development and validation of a predictive model for acute-onchronic liver failure after transjugular intrahepatic portosystemic shunt 认领 引用 被引量：1
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作者 Wei Zhang Ya-Ni Jin +5 位作者 Chang Sun Xiao-Feng Zhang Rui-Qi Li Qin Yin Jin-Jun Chen Yu-Zheng Zhuge 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第5期1301-1310,共10页
BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS)is a cause of acute-onchronic liver failure(ACLF).AIM To investigate the risk factors of ACLF within 1 year after TIPS in patients with cirrhosis and const... BACKGROUND Transjugular intrahepatic portosystemic shunt(TIPS)is a cause of acute-onchronic liver failure(ACLF).AIM To investigate the risk factors of ACLF within 1 year after TIPS in patients with cirrhosis and construct a prediction model.METHODS In total,379 patients with decompensated cirrhosis treated with TIPS at Nanjing Drum Tower Hospital from 2017 to 2020 were selected as the training cohort,and 123 patients from Nanfang Hospital were included in the external validation cohort.Univariate and multivariate logistic regression analyses were performed to identify independent predictors.The prediction model was established based on the Akaike information criterion.Internal and external validation were conducted to assess the performance of the model.RESULTS Age and total bilirubin(TBil)were independent risk factors for the incidence of ACLF within 1 year after TIPS.We developed a prediction model comprising age,TBil,and serum sodium,which demonstrated good discrimination and calibration in both the training cohort and the external validation cohort.CONCLUSION Age and TBil are independent risk factors for the incidence of ACLF within 1 year after TIPS in patients with decompensated cirrhosis.Our model showed satisfying predictive value. 展开更多
关键词 Acute-on-chronic liver failure Transjugular intrahepatic portosystemic shunt Influencing factor analysis Risk prediction model Nomogram
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Molecular Characterization and Expression Pattern of Rheb Gene in Inner Mongolia Cashmere Goat(Capra hircus) 认领 引用
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作者 ZHENG Xu YANG Jiao-fu +9 位作者 WANG Xiao-jing LIANG Yan WU Man-lin SHI Jie-jun ZHANG Tao QIN Yin LI Shu-yu HAO Xi-yan WANG Zhi-gang LIU Dong-jun 《Agricultural Sciences in China》 CSCD 2011年第9期1452-1458,共7页
As one member of the Ras super family,Rheb is an upstream regulator of mTOR signaling pathway,which regulates the process of cell-growth,proliferation and differentiation.In order to study the relationship between Rhe... As one member of the Ras super family,Rheb is an upstream regulator of mTOR signaling pathway,which regulates the process of cell-growth,proliferation and differentiation.In order to study the relationship between Rheb and mTOR in Inner Mongolian Cashmere goat(Capra hircus)cells,Ras homolog enriched in brain(Rheb)gene eDNA was amplified by RT-PCR.It is 555 bp in length and includes the complete ORF encoding 184 amino acids(GenBank accession no.HM569224).The full eDNA nucleotide sequence has a 99%identity with that of sheep,98%with cattle and 93%with human while their amino acids sequence shares identity with 98,97 and 97%of them,correspondingly.The bioinformatics analysis showed that Rheb has a Ras family domain,two casein kinase II phosphorylation sites,two ATP/GTP-binding sites motifA(P-loop),a prenyl group binding site(CAAX box).Tissue-specific expression analysis performed by semi-quantitative RT-PCR.The Rheb gene was expressed in all the tested tissues and the highest level ofmRNA accumulation was detected in brain,suggesting that Rheb played an important role in goat cells. 展开更多
关键词 Inner Mongolia Cashmere goat Rheb gene expression pattern
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Thermal and combustion behavior of Al-MnO2 nanothermite with poly(vinylidene fluoride-co-hexafluoropropylene) energetic binder 认领 引用 被引量：3
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作者 Jia-xing Song Tao Guo +7 位作者 Miao Yao Jia-lin Chen Wen Ding Feng-li Bei Xiao-nan Zhang Qin Yin Jun-yi Huang Chang-hao Li 《Defence Technology（防务技术）》 SCIE EI CAS CSCD 2021年第4期1289-1295,共7页
Fluoropolymers get increasing attention in energetic materials application due to the high fluorine content.To explore the effect of poly(vinylidene fluoride-co-hexafluoropropylene)(P(VDF-HFP))on Al/MnO2 nanothermi... Fluoropolymers get increasing attention in energetic materials application due to the high fluorine content.To explore the effect of poly(vinylidene fluoride-co-hexafluoropropylene)(P(VDF-HFP))on Al/MnO2 nanothermite,the samples with different contents are prepared and characterized by SEM,TGDSC,XRD,and their ignition and combustion behavior are tested and recorded.The results show that P(VDF-HFP)as an energetic binder can combine the nanothermite components together,even exist in the gaps.The integrity of energetic materials has been improved.Thermal analysis shows that the addition of P(VDF-HFP)greatly changes the thermal reaction processes,and the exothermic peaks appear early,but the utilization of fuel and oxidizer is not efficient from the XRD results.Furthermore,the appropriate addition of P(VDF-HFP)can directly reduce the ignition energy threshold and increase the combustion time,which is necessary for the potential ignition charge application.The possible reasons for above phenomena are discussed and analyzed.This research provides a reference for improvement of thermitebased ignition charge formulation. 展开更多
关键词 Nanothermite Fluoropolymers Combustion Thermal analysis
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Perpendicular magnetic anisotropy of Pd/Co2MnSi/NiFe2O4/Pd multilayers on F-mica substrates 认领 引用 被引量：1
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作者 Qingwang Bai Bin Guo +1 位作者 Qin Yin Shuyun Wang 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第1期568-572,共5页
Pd/Co2MnSi(CMS)/NiFe2O4(NFO)/Pd multilayers were fabricated on F-mica substrate by magnetron sputtering.The best PMA performance of the multilayer structure Pd(3 nm)/CMS(5 nm)/NFO(0.8 nm)/Pd(3 nm)was obtained... Pd/Co2MnSi(CMS)/NiFe2O4(NFO)/Pd multilayers were fabricated on F-mica substrate by magnetron sputtering.The best PMA performance of the multilayer structure Pd(3 nm)/CMS(5 nm)/NFO(0.8 nm)/Pd(3 nm)was obtained by adjusting the thickness of the CMS and NFO layers.F-mica substrate has a flatter surface than glass and Si/SiO2 substrate.The magnetic anisotropy energy density(Keff)of the sample deposited on F-mica substrates is 0.6711 Merg/cm3(1 erg=10-7 J),which is about 30%higher than that of the multilayer films deposited on glass(0.475 Merg/cm3)and Si/SiO2(0.511 Merg/cm3)substrates,and the RHall and HC are also significantly increased.In this study,the NFO layer prepared by sputtering in the high purity Ar environment was exposed to the high purity O2 atmosphere for 5 min,which can effectively eliminate the oxygen loss and oxygen vacancy in NFO,ensuring enough Co-O orbital hybridization at the interface of CMS/NFO,and thus effectively improve the sample PMA. 展开更多
关键词 perpendicular magnetic anisotropy Co2MnSi ferrimagnetics NiFe2O4
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High-performance self-powered photodetector based on organic/inorganic hybrid van der Waals heterojunction of rubrene/silicon 认领 引用
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作者 Yancai Xu Rong Zhou +3 位作者 Qin Yin Jiao Li Guoxiang Si Hongbin Zhang 《Chinese Physics B》 SCIE EI CAS CSCD 2021年第7期467-477,共11页
Organic/inorganic hybrid van der Waals heterostructure with an atomically abrupt interface has attracted great research interests within the field of multifunctional electronic and optoelectronic devices.The integrati... Organic/inorganic hybrid van der Waals heterostructure with an atomically abrupt interface has attracted great research interests within the field of multifunctional electronic and optoelectronic devices.The integration of organic rubrene films with inorganic Si semiconductors can avoid the atomic mutual-diffusion at the interface,and provide the possibility of forming two-dimensional van der Waals heterojunction accompanied with the type-II energy band alignment,due to the transfer behaviors of majority carriers at the interface.In this study,the high-quality rubrene/Si van der Waals heterostructure with an electronically abrupt junction was prepared,and a self-powered photodetector was then constructed based on this hybrid heterojunction.The photodetector demonstrated an excellent switching response to the 1064 nm monochromatic light with large on/off current ratio of 7.0×103,the maximum photocurrent of 14.62 m A,the maximum responsivity of 2.07 A/W,the maximum detectivity of 2.9×1011Jones,and a fast response time of 13.0μs.This study offers important guidance for preparing high-quality rubrene/Si hybrid van der Waals heterostructure with desirable band alignment,and the designed heterojunction photodetector has an important application prospect in the field of multifunctional optoelectronics. 展开更多
关键词 rubrene van der Waals heterojunction photodetector band alignment
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不同运动方式对妊娠期糖尿病患者代谢指标及妊娠结局的影响研究 认领 引用 被引量：84
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作者 钟鑫 黄秋红 +8 位作者 覃尹 曾雅畅 覃桂荣 陈青云 徐明 韦晓 马翠 黄燕凤 戴霞 《中国全科医学》 CAS 北大核心 2022年第6期699-705,共7页
背景妊娠期糖尿病(GDM)是妊娠期间常见疾病,可导致早产、巨大儿、剖宫产等并发症,严重影响母婴健康。目的探讨不同运动方式对GDM患者代谢指标及妊娠结局的影响,为GDM患者提供更适宜的运动方式。方法选取2019年8月至2020年12月于广西医... 背景妊娠期糖尿病(GDM)是妊娠期间常见疾病,可导致早产、巨大儿、剖宫产等并发症,严重影响母婴健康。目的探讨不同运动方式对GDM患者代谢指标及妊娠结局的影响,为GDM患者提供更适宜的运动方式。方法选取2019年8月至2020年12月于广西医科大学第一附属医院与广西医科大学第二附属医院收治的210例GDM患者为研究对象,采用Excel产生的随机数字序列将患者随机分为有氧运动(AT)组70例、抗阻运动(RT)组70例、RT+AT组70例。AT组患者进行中等强度步行运动,RT组患者采用坐位举重哑铃,RT+AT组采用中等强度步行+坐位哑铃联合方式。分别于干预前和干预后1个月、3个月及分娩时检测孕妇相关指标:空腹血糖(FBG)、餐后2 h血糖(2 hPBG)、糖化血红蛋白(HbA1c)、体质量、收缩压(SBP)、舒张压(DBP),并观察妊娠结局。结果AT组、RT组、RT+AT组最终有65例、64例、62例完成试验。各组干预1、3个月FBG、2 hPBG、SBP、DBP水平均低于同组干预前(P0.05)。RT+AT组剖宫产发生率低于AT组和RT组,RT组和RT+AT组产后出血量均低于AT组(P0.05);RT+AT组巨大儿发生率低于AT组(P<0.05)。结论AT、RT、RT+AT均能改善GDM患者的代谢指标,RT+AT更适宜;RT+AT改善GDM患者母婴结局优于AT、RT。 展开更多
关键词 糖尿病,妊娠 有氧运动 抗阻运动 联合抗阻-有氧运动 代谢 妊娠结局
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