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Rotation friction extrusion process towards high-performance Mg-Li matrix composites enhanced by FeCoNiCrCu high entropy alloy 认领 引用
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作者 Yuqing MAO Jinkai WANG +5 位作者 Qing HUANG Tengfei DU Shaopeng LIU Zhiwei QIN Xiao SONG Liming KE 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2026年第4期668-679,共12页
To pursue wide applications of Mg-Li alloys in aerospace field,bringing in reinforcement phases reasonably and manufacturing efficiently have become paramount.Herein,a novel rotation friction extrusion process was pro... To pursue wide applications of Mg-Li alloys in aerospace field,bringing in reinforcement phases reasonably and manufacturing efficiently have become paramount.Herein,a novel rotation friction extrusion process was proposed to fabricate Fe Co Ni Cr Cu high entropy alloy reinforced Mg-Li matrix composites,which were enhanced by newly formed nano-sized Al Cu Mg phase particles.The grain size of Mg-Li matrix composites was 4.19μm.Meanwhile,a 69.03 nm thickness amorphous layer was obtained,which was composed of amorphous and nanocrystalline structure.The maximum tensile strength reached 201.3 MPa,which was improved by 43.9%compared with LAZ933 Mg-Li alloy.It can be attributed to fine grain strengthening and dispersion strengthening,which resulted from dynamic recrystallization in Mg-Li alloy and Cu segregation from the interior of high entropy alloy.This work shows a novel processing and original reinforcement phase,providing a peculiar way to fabricate Mg-Li matrix composites. 展开更多
关键词 High entropy alloy Mechanical properties Mg-Li matrix composites Rotation friction extrusion Strengthening mechanism
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The impact of Cistanche on the therapeutic potential of acne after fermentation with Beauveria bassiana 认领 引用
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作者 Xingjiang Zhang Pan Wang +9 位作者 Yunwei Hu Hui Ke Rui Wang Xiaoya Zhang Huiyun Wu Baiyi Chi Yuyo Go Xi Hui Felicia Chan Qing Huang Jianxin Wu 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第3期1168-1178,共11页
Phenylethanol glycosides(PhGs) constitute crucial bioactive compounds in Cistanche Herba.However,their bioavailability is notably low.Research indicates that intestinal flora can metabolize PhGs into small polyphenols... Phenylethanol glycosides(PhGs) constitute crucial bioactive compounds in Cistanche Herba.However,their bioavailability is notably low.Research indicates that intestinal flora can metabolize PhGs into small polyphenols,enhancing bioavailability and pharmacological activities.In this paper,for the first time,a single strain,Beauveria bassiana,was found to be effective in converting PhGs from the crude extract of Cistanche tubulosa into small molecule polyphenols like hydroxytyrosol(HT),decaffeoylacteoside(HT-glu-rha),and caffeic acid through fermentation.We assessed the impact of pre-and post-fermentation on Propionibacterium acnes-induced acne related to a Western diet through in vitro cellular experiments.Both pre-and post-fermentation exhibited efficacy in inhibiting inflammation,oxidative stress,and mitochondrial membrane damage in P.acnes-induced HaCaT.Moreover,post-fermentation,unlike pre-fermentation,displayed stronger and a dose-dependent reduction in insulin-stimulated lipid synthesis in sebaceous gland cells.To further understand the increased efficacy of fermentation in inhibiting lipid synthesis,we investigated HT-glu-rha,the predominant small molecules produced during fermentation.It was shown that the compound inhibited lipid synthesis by decreasing gene expression of sterol regulatory element binding transcription factor 1(SREBP-1) and peroxisome proliferator activated receptor gamma(PPARγ) in sebaceous gland cells. 展开更多
关键词 Cistanche Fermentation Beauveria bassiana Acne Decaffeoylacteoside
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The extract of Cyperus rotundus rhizome promotes hair growth and modulates hair cycle in vivo and in vitro 认领 引用
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作者 Yunwei Hu Keke Hu +4 位作者 Jiaying Liang Xingjiang Zhang Huijuan Li Jianxin Wu Qing Huang 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2026年第2期203-214,共12页
Hair loss,a multifactorial disorder characterized by follicular miniaturization and excessive shedding,significantly impairs psychological well-being and quality of life.Cyperus rotundus rhizome(CR),a traditional Chin... Hair loss,a multifactorial disorder characterized by follicular miniaturization and excessive shedding,significantly impairs psychological well-being and quality of life.Cyperus rotundus rhizome(CR),a traditional Chinese medicine used for various ailments,has not been evaluated for efficacy in treating hair loss.This study presents the first comprehensive assessment of the hair growth-promoting effects of ethanol extract from CR on mouse primary dermal papilla cells(MDPCs)and human immortalized hair DPCs(IHHDPCs),employing cell counting kit-8(CCK-8),scratch assay,reverse transcription-quantitative polymerase chain reaction(RT-q PCR),and Western blot(WB).CR treatment activated the Wnt/β-Catenin signaling pathway by upregulating Wnt10b,increasingβ-Catenin protein levels and promoting its nuclear translocation,while simultaneously downregulating transforming growth factor-beta 1(TGF-β1),BMP4,and dickkopf-related protein 1(DKK1)in MDPCs.These molecular changes enhanced cell proliferation and increased secretion of key growth factors—insulin-like growth factor 1(IGF1),keratinocyte growth factor(KGF),and vascular endothelial growth factor(VEGF)—thereby stimulating hair growth and prolonging the anagen phase,which was confirmed in an ex vivo hair follicle(HF)organ culture model.Chromatographic analysis identified the petroleum ether fraction(CRP),enriched in sesquiterpenes,as the primary bioactive component.Both CR and CRP promoted IHHDPC proliferation,migration,and growth factor expression through activation of the Wnt/β-Catenin pathway,with CRP exhibiting superior bioactivity.Furthermore,both treatments stimulated HF cycling,increased follicular density,and upregulated Ki67 andβ-Catenin expression in the dorsal skin of C57BL/6 mice.Collectively,these findings demonstrate that CR and CRP promote hair growth and modulate the hair cycle via enhancement of Wnt/β-Catenin signaling,providing a scientific basis for the potential clinical application of C.rotundus rhizomes in hair loss therapy and the development of related pharmaceuticals or cosmetics. 展开更多
关键词 Cyperus rotundus Hair growth Hair cycle Wnt/β-Catenin
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Prediction model for rapid estimated glomerular filtration rate decline in type 2 diabetes mellitus 认领 引用
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作者 Peng Huang Xue-Qiong Qin +4 位作者 Qing Huang Si-Dan Wang Yuan-Yuan Wu Xiu-Rong Huang Xu Lin 《World Journal of Diabetes》 SCIE 2026年第4期116-130,共15页
BACKGROUND Diabetic kidney disease is the most common microvascular complication of type 2 diabetes mellitus(T2DM)and a leading cause of end-stage renal disease.Rapid estimated glomerular filtration rate(eGFR)decline(... BACKGROUND Diabetic kidney disease is the most common microvascular complication of type 2 diabetes mellitus(T2DM)and a leading cause of end-stage renal disease.Rapid estimated glomerular filtration rate(eGFR)decline(annual decline rate≥5 mL/minute/1.73 m2)is a strong predictor of end-stage renal disease and cardiovascular events,yet effective risk stratification tools are currently lacking in clinical practice.AIM To establish a comprehensive and accurate risk stratification system for patients with T2DM and kidney complications is of crucial importance for clinical decision-making.METHODS This retrospective cohort study enrolled 302 T2DM patients who attended our hospital from January 2021 to August 2024,with a minimum follow-up period of 12 months.Patients were divided into rapid decline group(≥5 mL/minute/1.73 m2,n=89)and non-rapid decline group(0.4).Compared with existing kidney failure risk equation 4,kidney failure risk equation 8,and Kidney Disease:Improving Global Outcomes stratification systems,our model showed significant advantages(P<0.05)with net reclassification improvement of 0.385-0.428 and integrated discrimination improvement of 0.076-0.156 in external validation.CONCLUSION This work effectively developed a nomogram model with good discrimination,calibration,and clinical applicability for risk stratification of rapid eGFR drop among T2DM patients with indications of kidney involvement.The model integrates both established risk variables and new risk markers. 展开更多
关键词 Type 2 diabetes mellitus Estimated glomerular filtration rate Rapid decline Risk factors Prediction model Nomogram Machine learning
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Observation on the Effect of Specialized Respiratory Tract Care in Preventing Pulmonary Infection after Cardiothoracic Surgery 认领 引用
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作者 Qing Huang 《Journal of Clinical and Nursing Research》 2026年第6期390-397,共8页
Objective:To compare the application effects of routine care and routine care combined with specialized respiratory tract care in patients after cardiothoracic surgery.Methods:This study involved 102 patients who unde... Objective:To compare the application effects of routine care and routine care combined with specialized respiratory tract care in patients after cardiothoracic surgery.Methods:This study involved 102 patients who underwent cardiothoracic surgery in our hospital from September 2024 to December 2025.They were randomly divided into a control group(51 cases)and an observation group(51 cases).The control group received routine postoperative care for cardiothoracic surgery,while the observation group received specialized respiratory tract care in addition to routine care.The postoperative recovery,effective expectoration rate,and incidence of postoperative pulmonary complications were compared between the two groups.Results:The observation group had shorter ICU stays,drainage tube indwelling times,and hospital stays than the control group,with p<0.05.The effective expectoration rate in the observation group was higher than that in the control group,with p<0.05.The total incidence of postoperative pulmonary complications in the observation group was lower than that in the control group,with p<0.05.Conclusion:Adding specialized respiratory tract care to routine postoperative care in cardiothoracic surgery can effectively improve the effective expectoration rate,reduce the incidence of pulmonary complications,and promote postoperative recovery in patients. 展开更多
关键词 Cardiothoracic surgery Postoperative Pulmonary infection Respiratory tract Specialized care
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Recent Progress in Silicon‐Based Anodes for High‐Energy Lithium‐Ion Batteries: From the Perspective of “Size Effects” 认领 引用 被引量：3
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作者 Wengang Yan Zitong Chen +7 位作者 Yuefeng Su Yun Lu Lai Chen Qing Huang Meng Wang Yibiao Guan Feng Wu Ning Li 《Carbon Energy》 SCIE EI CSCD 2025年第11期1-22,共22页
Silicon‐based anode materials have garnered considerable attention in lithium‐ion batteries(LIBs)due to their exceptionally high theoretical capacity and energy density.However,intrinsic challenges,such as significa... Silicon‐based anode materials have garnered considerable attention in lithium‐ion batteries(LIBs)due to their exceptionally high theoretical capacity and energy density.However,intrinsic challenges,such as significant volumetric expansion and the consequent degradation in cycling stability,severely hinder their practical application.As a result,development of silicon anodes that can effectively mitigate volumetric expansions,enhance cycling durability,and improve rate performance has emerged as a critical research focus.However,due to neglect of“size effects”,the modification strategy of silicon‐based electrodes lacks systematic,scientific,and comprehensive guidance.Herein,this review starts from the“size effect”of silicon‐based materials,and reveals in depth the different failure mechanisms of nano‐silicon(Si NPs)and micro‐silicon(μSi).Furthermore,this review provides targeted classification of modification strategies for Si NPs andμSi,and reviews comprehensively,in detail,and in depth the latest research progress on silicon‐based materials.In addition,the review also comprehensively summarizes the cutting‐edge dynamics of matching silicon‐based electrodes with solid electrolytes to construct high‐energy LIBs.It is hoped that this review can provide comprehensive and systematic scientific guidance for modification strategies of silicon‐based electrodes,which is of great significance for promoting the industrialization process of silicon‐based electrodes in high‐energy LIBs. 展开更多
关键词 all‐solid‐state battery lithium‐ion battery micro‐silicon nano‐silicon size effect
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Ion transport behaviors in MXenes for electrochemical energy storage and conversion 认领 引用 被引量：2
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作者 Ling Fei Lei Lei +6 位作者 Hui Xu Xinghua Guo Bo Chen Xu Han Xun Chen Qing Huang Degao Wang 《Carbon Energy》 SCIE EI CSCD 2025年第3期110-132,共23页
MXenes,an innovative class of two-dimensional(2D)materials composed of transition-metal carbides and/or nitrides,have garnered significant interest for their potential in energy storage and conversion applications,whi... MXenes,an innovative class of two-dimensional(2D)materials composed of transition-metal carbides and/or nitrides,have garnered significant interest for their potential in energy storage and conversion applications,which is largely attributed to their modifiable surface terminations,exceptional conductivity,and favorable hydrophilic characteristics.MXenes show various ion transport behaviors in applications like electrochemical catalysis,supercapacitors,and batteries,encompassing processes like electrostatic adsorption of surface ions,redox reactions of ions,and interlayer ion shuttle.This review aims to present a summary of advancements in the comprehension of ion transport behaviors of Ti3C2TxMXenes.First,the composition,properties,and synthesis techniques of MXenes are concisely summarized.Subsequently,the discussion delves into the mechanisms of ion transport in MXenes during CO2reduction,water splitting,supercapacitor operation,and battery performance,elucidating the factors determining the electrochemical behaviors and efficacy.Furthermore,a compilation of strategies used to optimize ion transport behaviors in MXenes is presented.The article concludes by presenting the challenges and opportunities for these fields to facilitate the continued progress of MXenes in energy-related technologies. 展开更多
关键词 CO2reduction ion transport MXenes storage batteries supercapacitors water splitting
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Enhancing structural and thermal stability of ultrahigh-Ni cathodes via anion-cation codoping induced surface reconstruction strategy 认领 引用 被引量：2
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作者 Haoyu Wang Jinyang Dong +9 位作者 Hongyun Zhang Jinzhong Liu Yun Lu Yun Liu Xi Wang Ning Li Qing Huang Feng Wu Yuefeng Su Lai Chen 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2025年第7期9-19,共11页
The rapid expansion of the automotive sector has significantly increased the demand for highperformance lithium-ion batteries,positioning Ni-rich layered cathodes as a promising solution due to their high energy densi... The rapid expansion of the automotive sector has significantly increased the demand for highperformance lithium-ion batteries,positioning Ni-rich layered cathodes as a promising solution due to their high energy density and cost-efficiency.However,these cathodes face critical challenges,including thermal instability and structural degradation at an elevated temperature,which hinder their practical application.This study introduces an advanced surface reconstruction strategy combining a LiScF4coating,Sc/F surface co-doping,and a cation-mixing layer to address these issues.The LiScF4coating serves as a durable protective barrier,reducing electrolyte decomposition,minimizing transition metal dissolution,and enhancing lithium-ion transport.Sc/F surface co-doping stabilizes lattice oxygen by increasing the energy barrier for oxygen vacancy formation and minimizing oxygen release,thereby suppressing phase transitions and interfacial side reactions.Additionally,the cation-mixing layer improves interfacial stability by alleviating lattice strain and supporting reversible cation migration,ensuring prolonged durability during cycling and under high-temperature conditions.These integrated modifications work synergistically to mitigate various degradation mechanisms,significantly improving the thermal stability,structural integrity,and electrochemical performance of Ni-rich cathodes.This approach offers a viable pathway for incorporating Ni-rich cathodes into advanced lithium-ion batteries,making them well-suited for applications requiring high thermal stability.Moreover,this research provides valuable guidance for the development of a multi-component modification strategy,paving the way for future innovations in energy storage materials and advancing high-performance battery technology. 展开更多
关键词 Lithium-ion batteries Ultrahigh-nickel layered cathodes Codoping-induced surface reconstruction Cycling performance Structure and thermal stability
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Synergistic surface restructuring and cation mixing via ultrafast Joule heating enhancing ultrahigh-nickel cathodes for advanced lithium-ion batteries 认领 引用 被引量：2
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作者 Haoyu Wang Jinyang Dong +10 位作者 Meng Wang Yun Lu Hongyun Zhang Jinzhong Liu Yun Liu Na Liu Ning Li Qing Huang Feng Wu Yuefeng Su Lai Chen 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2025年第4期371-382,共12页
The implementation of ultrahigh-Ni cathodes in high-energy lithium-ion batteries(LIBs)is constrained by significant structural and interfacial degradation during cycling.In this study,doping-induced surface restructur... The implementation of ultrahigh-Ni cathodes in high-energy lithium-ion batteries(LIBs)is constrained by significant structural and interfacial degradation during cycling.In this study,doping-induced surface restructuring in ultrahigh-nickel cathode materials is rapidly facilitated through an ultrafast Joule heating method.Density functional theory(DFT)calculations,synchrotron X-ray absorption spectroscopy(XAS),and single-particle force test confirmed the establishment of a stable crystal framework and lattice oxygen,which mitigated H2-H3 phase transitions and improved structural reversibility.Additionally,the Sc doping process exhibits a pinning effect on the grain boundaries,as shown by scanning transmission electron microscopy(STEM),enhancing Li~+diffusion kinetics and decreasing mechanical strain during cycling.The in situ development of a cation-mixing layer at grain boundaries also creates a robust cathode/electrolyte interphase,effectively reducing interfacial parasitic reactions and transition metal dissolution,as validated by STEM and time-of-flight secondary ion mass spectrometry(TOF-SIMS).These synergistic modifications reduce particle cracking and surface/interface degradation,leading to enhanced rate capability,structural integrity,and thermal stability.Consequently,the optimized Sc-modified ultrahigh-Ni cathode(Sc-1)exhibits 93.99%capacity retention after 100 cycles at 1 C(25℃)and87.06%capacity retention after 100 cycles at 1 C(50℃),indicating excellent cycling and thermal stability.By presenting a one-step multifunctional modification approach,this research delivers an extensive analysis of the mechanisms governing the structure,microstructure,and interface properties of nickel-rich layered cathode materials(NCMs).These results underscore the potential of ultrahigh-Ni cathodes as viable candidates for advanced lithium-ion batteries(LIBs)in next-generation electric vehicles(EVs). 展开更多
关键词 Lithium-ion batteries Ultrahigh-nickel layered cathodes In situ surface doping Cation mixing layer Structure and thermal stability
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Enhancing the radiation- and oxidation-resistance of Cr-based coatings via structure regulation and composition optimization 认领 引用 被引量：1
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作者 Renda Wang Nabil Daghbouj +8 位作者 Ping Yu Peng Li Fanping Meng Antonio Cammarata Bingsheng Li P.Bábor Tomas Polcar Qing Huang Fangfang Ge 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2025年第15期153-169,共17页
Cr coatings,as protective coatings of Zr-alloy fuel claddings,inevitably suffer from irradiation damage before they would possibly run into the accident condition.This study evaluates the radiation and oxidation toler... Cr coatings,as protective coatings of Zr-alloy fuel claddings,inevitably suffer from irradiation damage before they would possibly run into the accident condition.This study evaluates the radiation and oxidation tolerance of three Cr-based coatings with different microstructures(Cr,CrAlSi,and CrAlSiN)through He2+ion irradiation and 1200℃ steam oxidation.The Cr and CrAlSi coatings experienced significant structural degradation,characterized by He bubble aggregation and amplified Kirkendall effects at elevated temperatures.In contrast,the irradiated CrAlSiN coating maintained structural integrity without measurable irradiation hardening.Following annealing at 800℃ for 30 min,approximately 40%of injected He atoms were released,indicating a“self-healing”mechanism.The mechanism is attributed to uniformly distributed,low-density channels that act as sinks and release paths for irradiation-induced defects.Density functional theory simulations suggest that N atoms promote significant rearrangement of ions surrounding the free volume,inhibiting the formation of sites capable of trapping He atoms.Moreover,the CrAlSiN coating exhibited superior oxidation resistance compared to the Cr and CrAlSi coatings,even under high-temperature steam conditions.Notably,the irradiated CrAlSiN sample displayed a significantly thinner oxide scale compared to the pristine one(almost half),owing to a more protective oxide scale and rapid outward diffusion of Cr,Al,and Si through nanochannel veins.These findings illuminate the effects of structure and composition on irradiation and oxidation behavior in Cr-based coatings,offering insights for developing new-generation accident-tolerance fuel coatings for Zr-alloy claddings. 展开更多
关键词 Cr-based coatings Irradiation tolerance Low-density nanochannels Oxidation resistance DFT
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Resolving the spatial and cellular architecture of intra-tumor heterogeneity by multi-region dissection of lung adenocarcinoma 认领 引用 被引量：1
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作者 Song Mei Xiaolei Wang +12 位作者 Mengmeng Zhao Qing Huang Yixuan Huang Mingming Su Xinlei Zhang Xu Wang Xueyu Hao Tianning Wang Yanhua Wu Yuanhui Ma Jingnan Wang Peng Zhang Yan Zheng 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2025年第9期1121-1132,共12页
Although the spatial characteristics within the tumor microenvironment of lung adenocarcinoma(LUAD)have been identified,the mechanisms by which these factors promote LUAD progression and immune evasion remain unclear.... Although the spatial characteristics within the tumor microenvironment of lung adenocarcinoma(LUAD)have been identified,the mechanisms by which these factors promote LUAD progression and immune evasion remain unclear.Using spatial transcriptomics and single-cell RNA-sequencing data from multi-regional LUAD biopsies consisting of tumor core,tumor edge,and normal area,we sought to delineate the spatial heterogeneity and driving factors of cell colocalization.Two cancer cell sub-clusters(Cancer_c1 and Cancer_c2),associated with LUAD initiation and metastasis,respectively,exhibit distinct spatial distributions and immune cell colocalizations.In particular,Cancer_c1,enriched within the tumor core,could directly interact with B cells or indirectly recruit B cells through macrophages.Conversely,Cancer_c2 enriched within the tumor edge exhibits colocalization with CD8+T cells.Collectively,our work elucidates the spatial distribution of cancer cell subtypes and their interaction with immune cells in the core and edge of LUAD,providing insights for developing therapeutic strategies for cancer intervention. 展开更多
关键词 Lung adenocarcinoma Spatial transcriptomics ScRNA-Seq Intra-tumoral heterogeneity Cell colocalizations
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Bone marrow mesenchymal stem cell-derived exosomal lactate dehydrogenase A promotes tendon-bone healing via histone lactylation-mediated cartilage regeneration 认领 引用 被引量：2
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作者 Ting Zhang Qing Huang Kai-Feng Gan 《World Journal of Stem Cells》 SCIE 2025年第9期138-150,共13页
BACKGROUND Anterior cruciate ligament reconstruction(ACLR)is the dominant clinical modality for the treatment of anterior cruciate ligament injuries.The success of ACLR is largely dependent on tendon-bone healing,and ... BACKGROUND Anterior cruciate ligament reconstruction(ACLR)is the dominant clinical modality for the treatment of anterior cruciate ligament injuries.The success of ACLR is largely dependent on tendon-bone healing,and stem cell biotherapies are often used to facilitate this process.Histone lactylation modifications are involved in the regulation of various diseases.Lactate dehydrogenase A(LDHA)has been shown to play an important role in exosomes.AIM To explore the regulation of tendon-bone healing after ACLR by LDHA in exosomes derived from bone marrow mesenchymal stem cells(BMSC-Exos).METHODS BMSC-Exos and LDHA were characterized and analyzed by transmission electron microscopy,qNano,immunofluorescence and western blotting assay.The corresponding low expression cell lines were obtained using RNA interference transfection;LDHA expression in rat bone tissues after ACLR was analyzed by western blotting.The volume of newborn bone tissues was monitored by micro-computed tomography imaging.Tendon and fibrocartilage regeneration were further analyzed and calculated by histological analysis,including hematoxylin and eosin and Safranin O-Fast green staining,respectively;LDHA levels of chondrocyte stem cells(CSPCs)after co-incubation with BMSC-Exos were analyzed by western blotting.Extracellularly secreted lactic acid content was determined by lactate assay kit.Cell viability was assessed by cell counting kit 8 assay,and the proliferation and differentiation ability of cells was further examined by the expression of collagen II,SOX9 and aggrecan.Histone H3K18 lactylation modification was analyzed by western blotting.H3K18 La binding on bone morphogenetic protein 7(BMP7)promoter was analyzed by chromatin immunoprecipitation-quantitative polymerase chain reaction;BMP7 promoter activity was analyzed by dual luciferase reporter gene;BMP7 protein expression was analyzed using quantitative polymerase chain reaction and western blotting.Then,the proliferation of CSPCs promoted by BMSC-Exos LDHA was analyzed by protein expression levels of LDHA,BMP7,collagen II,SOX9,aggrecan,extracellular lactate content,and cell counting kit 8 assay.RESULTS The spherical nanosized BMSC-Exos could be uptaken by CSPCs.LDHA was highly expressed in BMSC-Exos,which could infiltrate into the bone tissue of ACLR rats and promoted the generation of new bone tissue,as well as significantly increased the regeneration of tendon and fibrocartilage.Co-incubation of CSPCs with high-expressing LDHA BMSC-Exos increased the secretion of lactate content from CSPCs,cell viability,and the expression of markers related to cell proliferation and differentiation,including collagen II,SOX9,and aggrecan;LDHA in BMSC-Exos upregulated BMP7 through histone H3K18 lactate modification;high LDHA expression reversed the knockdown of BMP7,further increasing the proliferation and differentiation of CSPCs,thereby inducing cartilage formation.CONCLUSION LDHA in BMSC-Exos promotes BMP7 expression via H3K18 lactylation modification,which further promotes tendon-bone healing after ACLR. 展开更多
关键词 Tendon-bone healing Bone mesenchymal stromal cells Exosome Lactate dehydrogenase A Histone lactylation modification Cartilage fragments
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Performance optimization of aqueous Zn/MnO2batteries through the synergistic effect of PVP intercalation and GO coating 认领 引用 被引量：2
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作者 Shilong Li Ming Zhao +4 位作者 Yefei Xu Zhanyi Liu Mian Li Qing Huang Xiang Wu 《Chinese Chemical Letters》 SCIE CAS CSCD 2025年第3期488-493,共6页
Manganese dioxide(MnO2)electrode material possesses the advantages of high energy density,structural diversity and high modification potential.This allows it become one of the important cathodes for aqueous zinc io... Manganese dioxide(MnO2)electrode material possesses the advantages of high energy density,structural diversity and high modification potential.This allows it become one of the important cathodes for aqueous zinc ion battery.However,the applications are limited by the poor electrical conductivity,narrow layer spacing and the ease of dissolution.Herein,we prepare MnO2-PVP@0.03GO composites by the co-modification of polyvinylpyrrolidone(PVP)pre-insertion layer and graphene oxide(GO)self-assembly layer.The Zn//MnO2-PVP@0.03GO cells deliver a discharge specific capacity of 442 mAh/g at a current density of 0.2 A/g.It also maintains 100%capacity for 1000 times cycling at 1 A/g.The assembled soft package batteries demonstrate superior flexibility and adaptability under different bending conditions. 展开更多
关键词 Aqueous zinc ion batteries Cathode MnO2 Cycle stability High capacity
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MA-VoxelMorph:Multi-scale attention-based VoxelMorph for nonrigid registration of thoracoabdominal CT images 认领 引用
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作者 Qing Huang Lei Ren +3 位作者 Tingwei Quan Minglei Yang Hongmei Yuan Kai Cao 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2025年第1期135-151,共17页
This paper aims to develop a nonrigid registration method of preoperative and intraoperative thoracoabdominal CT images in computer-assisted interventional surgeries for accurate tumor localization and tissue visualiz... This paper aims to develop a nonrigid registration method of preoperative and intraoperative thoracoabdominal CT images in computer-assisted interventional surgeries for accurate tumor localization and tissue visualization enhancement.However,fine structure registration of complex thoracoabdominal organs and large deformation registration caused by respiratory motion is challenging.To deal with this problem,we propose a 3D multi-scale attention VoxelMorph(MAVoxelMorph)registration network.To alleviate the large deformation problem,a multi-scale axial attention mechanism is utilized by using a residual dilated pyramid pooling for multi-scale feature extraction,and position-aware axial attention for long-distance dependencies between pixels capture.To further improve the large deformation and fine structure registration results,a multi-scale context channel attention mechanism is employed utilizing content information via adjacent encoding layers.Our method was evaluated on four public lung datasets(DIR-Lab dataset,Creatis dataset,Learn2Reg dataset,OASIS dataset)and a local dataset.Results proved that the proposed method achieved better registration performance than current state-of-the-art methods,especially in handling the registration of large deformations and fine structures.It also proved to be fast in 3D image registration,using about 1.5 s,and faster than most methods.Qualitative and quantitative assessments proved that the proposed MA-VoxelMorph has the potential to realize precise and fast tumor localization in clinical interventional surgeries. 展开更多
关键词 Thoracoabdominal CT image registration large deformation fine structure multi-scale attention mechanism
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Risk of chronic drug-induced liver injury in patients with psoriasis:based on NHANES 2009–2014 认领 引用
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作者 Hao Jiang Xiaole Mei +1 位作者 Chunjun Yang Qing Huang 《中国科学技术大学学报》 CAS CSCD 北大核心 2025年第9期55-65,I0002,共11页
Objective:This study aims to utilize data from the National Health and Nutrition Examination Survey(NHANES),which was conducted in the United States from 2009 to 2014,to investigate the risk of chronic drug-induced li... Objective:This study aims to utilize data from the National Health and Nutrition Examination Survey(NHANES),which was conducted in the United States from 2009 to 2014,to investigate the risk of chronic drug-induced liver injury(DILI)in patients with psoriasis and to establish a risk prediction model via machine learning.Methods:A total of 6,303 participants were selected,all of whom answered questions regarding psoriasis and drug use.Chronic DILI was diagnosed on the basis of persistent abnormalities in the serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),and total bilirubin(TBIL)levels.Multiple logistic regression and other methods have been employed in different models to explore the relationship between psoriasis and chronic DILI.Potential confounding factors(age,sex,ethnicity,household income,education,alcohol consumption,smoking,and body mass index(BMI))were controlled.Results:After controlling for potential confounding factors,the results revealed a significant positive correlation between psoriasis and chronic DILI,and an optimal predictive model was generated on the basis of diabetes status and BMI.Conclusion:Patients with psoriasis appear to be at increased risk of chronic DILI.More prospective studies are needed to confirm this clinical correlation. 展开更多
关键词 drug-induced liver injury(DILI) psoriasis machine learning chronic disease body mass index(BMI)
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Rogue wave patterns in the nonlinear Schrodinger–Boussinesq system 认领 引用
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作者 Xiaoyu Cheng Qing Huang 《Communications in Theoretical Physics》 SCIE CAS CSCD 2025年第7期25-32,共8页
To the nonlinear Schrodinger–Boussinesq system,with the aid of Adler–Moser polynomials we predict the patterns of higher-order rogue wave solutions containing multiple large parameters.The new interesting rogue wave... To the nonlinear Schrodinger–Boussinesq system,with the aid of Adler–Moser polynomials we predict the patterns of higher-order rogue wave solutions containing multiple large parameters.The new interesting rogue wave patterns of a number of true and predicted solutions are graphically illustrated,including fan-,heart-shaped structures and their skewed versions.The results are significant for both experimental and theoretical studies of rogue wave patterns of integrable systems. 展开更多
关键词 rogue wave nonlinear Schrodinger–Boussinesq system Adler–Moser polynomial asymptotics
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Different treatment strategies and molecular features between right-sided and left-sided colon cancers 认领 引用 被引量：41
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作者 Hong Shen Jiao Yang +6 位作者 Qing Huang Meng-Jie Jiang Yi-Nuo Tan Jian-Fei Fu Li-Zhen Zhu Xue-Feng Fang Ying Yuan 《World Journal of Gastroenterology》 SCIE CAS 2015年第21期6470-6478,共9页
The colon is derived from the embryological midgut and hindgut separately,with the right colon and left colon having different features with regards to both anatomical and physiological characteristics.Cancers located... The colon is derived from the embryological midgut and hindgut separately,with the right colon and left colon having different features with regards to both anatomical and physiological characteristics.Cancers located in the right and left colon are referred to as right colon cancer(RCC) and left colon cancer(LCC),respectively,based on their apparent anatomical positions.Increasing evidence supports the notion that not only are there differences in treatment strategies when dealing with RCC and LCC,but molecular features also vary between them,not to mention the distinguishing clinical manifestations.Disease-free survival after radical surgery of both RCC and LCC are similar.In the treatment of RCC,the benefit gained from adjuvant FOLFIRI chemotherapy is superior,or at least similar,to LCC,but inferior to LCC if FOLFOX regimen is applied.On the other hand,metastatic LCC exhibits longer survival than that of RCC in a palliative chemotherapy setting.For KRAS wild-type cancers,LCC benefits more from cetuximab treatment than RCC.Moreover,advanced LCC shows a higher sensitivity to bevacizumab treatment in comparison with advanced RCC.Significant varieties exist at the molecular level between RCC and LCC,which may serve as the cause of all apparent differences.With respect to carcinogenesis mechanisms,RCC is associated with known gene types,such as MMR,KRAS,BRAF,and mi RNA-31,while LCC is associated with CIN,p53,NRAS,mi RNA-146 a,mi RNA-147 b,and mi RNA-1288.Regarding protein expression,RCC is related to GNAS,NQO1,telomerase activity,P-PDH,and annexin A10,while LCC is related to Topo I,TS,and EGFR.In addition,separated pathways dominate progressionto relapse in RCC and LCC.Therefore,RCC and LCC should be regarded as two heterogeneous entities,with this heterogeneity being used to stratify patients in order for them to have the optimal,current,and novel therapeutic strategies in clinical practice.Additional research is needed to uncover further differences between RCC and LCC. 展开更多
关键词 Colon cancer Right Left Survival Molecular
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Experiment and numerical simulation of two-phase flow in oxygen enriched side-blown furnace 认领 引用 被引量：29
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作者 Yan-ting LIU Tian-zu YANG +3 位作者 Zhuo CHEN Zhen-yu ZHU Ling ZHANG Qing HUANG 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2020年第1期249-258,共10页
Taking an oxygen enriched side-blown furnace as the prototype,a hydraulic model was established according to the similarity principle.The influence of three factors on the gas-liquid two-phase flow was analyzed,i.e.th... Taking an oxygen enriched side-blown furnace as the prototype,a hydraulic model was established according to the similarity principle.The influence of three factors on the gas-liquid two-phase flow was analyzed,i.e.the airflow speed,the submerged depth and the downward angle of the nozzle.A numerical simulation of the hydraulic model was carried out trying to find the suitable turbulence model which can describe the side-blown two-phase flow correctly by comparing the simulation results with the experimental data.The experiment shows that the airflow speed has a great influence on the flow of the water.The submerged depth of the nozzle has a relatively smaller influence on the penetration depth and the surface fluctuation height in the liquid phase.When the nozzle is at a downward angle of 15°,the penetration depth and the surface fluctuation height are reduced.It is concluded that the numerical results with the realizable k-εturbulence model are the closest to the experiment for the penetration depth,the surface fluctuation height and the bubble scale. 展开更多
关键词 side-blown furnace hydraulic model numerical simulation turbulence model
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Hydrometallurgical recycling of valuable metals from spent lithium-ion batteries by reductive leaching with stannous chloride 认领 引用 被引量：13
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作者 Liu-ye Sun Bo-rui Liu +4 位作者 Tong Wu Guan-ge Wang Qing Huang Yue-feng Su Feng Wu 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2021年第6期991-1000,共10页
The reductant is a critical factor in the hydrometallurgical recycling of valuable metals from spent lithium-ion batteries(LIBs).There is limited information regarding the use of SnCl2 as a reductant with organic a... The reductant is a critical factor in the hydrometallurgical recycling of valuable metals from spent lithium-ion batteries(LIBs).There is limited information regarding the use of SnCl2 as a reductant with organic acid(maleic acid)for recovering valuable metals from spent Li-CoO2 material.In this study,the leaching efficiencies of Li and Co with 1 mol·L−1 of maleic acid and 0.3 mol·L−1 of SnCl2 were found to be 98.67%and 97.5%,respectively,at 60°C and a reaction time of 40 min.We investigated the kinetics and thermodynamics of the leaching process in this study to better understand the mechanism of the leaching process.Based on a comparison with H2O2 with respect to leaching efficiency,the optimal leaching parameters,and the activation energy,we determined that it is feasible to replace H2O2 with SnCl2 as a leaching reductant in the leaching process.In addition,when SnCl2 is used in the acid-leaching process,Sn residue in the leachate may have a positive effect on the re-synthesis of nickel-rich cathode materials.Therefore,the results of this study provide a potential direction for the selection of reductants in the hydrometallurgical recovery of valuable metals from spent LIBs. 展开更多
关键词 spent lithium-ion batteries recovery maleic acid reductant stannous chloride
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A gel polymer electrolyte with IL@UiO-66-NH2as fillers for high-performance all-solid-state lithium metal batteries 认领 引用 被引量：8
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作者 Tao Wei Qi Zhang +7 位作者 Sijia Wang Mengting Wang Ye Liu Cheng Sun Yanyan Zhou Qing Huang Xiangyun Qiu Fang Tian 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2023年第10期1897-1905,共9页
All solid-state electrolytes have the advantages of good mechanical and thermal properties for safer energy storage,but their energy density has been limited by low ionic conductivity and large interfacial resistance ... All solid-state electrolytes have the advantages of good mechanical and thermal properties for safer energy storage,but their energy density has been limited by low ionic conductivity and large interfacial resistance caused by the poor Li~+transport kinetics due to the solid-solid contacts between the electrodes and the solid-state electrolytes.Herein,a novel gel polymer electrolyte(UPP-5)composed of ionic liquid incorporated metal-organic frameworks nanoparticles(IL@MOFs)is designed,it exhibits satisfying electrochemical performances,consisting of an excellent electrochemical stability window(5.5 V)and an improved Li+transference number of 0.52.Moreover,the Li/UPP-5/LiFePO4full cells present an ultra-stable cycling performance at 0.2C for over 100 cycles almost without any decay in capacities.This study might provide new insight to create an effective Li+conductive network for the development of all-solid-state lithium-ion batteries. 展开更多
关键词 all solid-state lithium-ion batteries metal-organic frameworks gel polymer electrolytes ionic liquid solid electrolyte interphase
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