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Expert consensus on the detection and clinical application of tumor mutational burden 认领 引用
1
作者 Zhenying Guo Chunwei Xu +168 位作者 Shirong Zhang Yue Hao Xiaotong Hu Ming Zhao Chan Xiang Yingshi Piao Pingli Sun Xueping Xiang Jing Zhao Huanwen Wu Weixing Li Jinpu Yu Jingping Yuan Shuangshuang Wang Cong Wang Yun Gu Bingjian Lv Liping Zhang Yueping Liu Xiaobin Cui Weizhong Gu Yining Li Wei Wang Wenjun Yang Weiguo Long Jingjing Xiang Hong Mou Biao Liu Huajuan Ruan Yubin Wang Yongjie Zhu Feng Wang Zhonghua Wang Xiaomin Feng Xing Liu Peng Li Min Deng Bin Lian Lili Mao Qian Wang Wenxian Wang Zhengbo Song Ziming Li Wenzhao Zhong Zhijie Wang Shengxiang Ren Wenfeng Fang Yongchang Zhang Jingjing Liu Xiuyu Cai Anwen Liu Wen Li Ping Zhan Hongbing Liu Tangfeng Lv Liyun Miao Lingfeng Min Yu Chen Yu Zhang Feng Wang Zhansheng Jiang Gen Lin Long Huang Xingxiang Pu Rongbo Lin Weifeng Liu Chuangzhou Rao Dongqing Lv Zongyang Yu Peng Shen Xiaoyan Li Chuanhao Tang Chengzhi Zhou Junping Zhang Junli Xue Hui Guo Qian Chu Rui Meng Jingxun Wu Rui Zhang Jin Zhou Zhengfei Zhu Yongheng Li Hong Qiu Fan Xia Yuanyuan Lu Xiaofeng Chen Rui Ge Enyong Dai Yu Han Jian Zhang Yinghua Ji Xianbin Liang Hongmei Zhang Xuelei Ma Xuewen Liu Yu Yao Peng Luo WeiWei Pan Fei Pang Fan Wu Dejian Gu Li Wang Liping Wang Youcai Zhu Li Lin Weiwen Li Xinqing Lin Jing Cai Ling Xu Jisheng Li Xiaodong Jiao Kainan Li Jia Wei Huijing Feng Lin Wang Yingying Du Wang Yao Xuefei Shi Xiaomin Niu Dongmei Yuan Yanwen Yao Yinbin Zhang Binbin Song Wenfeng Li Jianfei Fu Hong Wang Mingxiang Ye Dong Wang Zhaofeng Wang Qing Ji Yuan Fang Qing Wei Zhen Wang Bin Wan Donglai Lv Xiaofeng Li Shengjie Yang Jing Kang Jiatao Zhang Chao Zhang Lin Shi Yina Wang Bihui Li Zhang Zhang Ke Wang Zhefeng Liu Nong Yang Lin Wu Xiaobing Chen Gu Jin Zhongwu Li Miao Li Guansong Wang Jiandong Wang Meiyu Fang Yong Fang Xiaojia Wang Jing Chen Yiping Zhang Xixu Zhu Yi Shen Shenglin Ma Biyun Wang Lu Si Yong Song Yuanzhi Lu Aijun Liu Yuchen Han 《Cancer Biology & Medicine》 SCIE CAS CSCD 2026年第2期218-246,共29页
As an emerging biomarker,tumor mutational burden(TMB)has attracted increasing attention from clinicians in predicting the efficacy of tumor immunotherapy.Currently,TMB is detected primarily by whole-exome sequencing o... As an emerging biomarker,tumor mutational burden(TMB)has attracted increasing attention from clinicians in predicting the efficacy of tumor immunotherapy.Currently,TMB is detected primarily by whole-exome sequencing or targeted panel sequencing on high-throughput sequencing platforms.However,the lack of uniformity in detection methods,threshold settings,and reporting formats,as well as the significant differences in TMB values among different cancer types,have hindered the standardized application of this biomarker in clinical practice.This consensus focuses on the definition,standardization of detection,clinical significance,and limitations of TMB,and provides consensus recommendations for the clinical application of TMB in real-world practice in China.This consensus is aimed at helping clinicians and laboratory personnel understand the clinical significance and testing standards of TMB,promoting more accurate interpretation of test results,and improving patient care. 展开更多
关键词 Biomarkers tumor mutational burden tumor immunotherapy targeted panel sequencing whole-exome sequencing
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R-napropamide drives herbicide-induced cadmium accumulation in Arabidopsis via enantiomer-specific nutrient crosstalk 认领 引用
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作者 Yaxin Zhu Minghui Xie +6 位作者 Haoqi Cui Ran Wu Lukuan Huang Qing Wei Lijuan Liu Miaozhen Cai Shaoting Du 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第8期658-668,共11页
Soil heavy metal contamination has emerged as a critical global environmental issue due to industrialization,posing severe threats to human health.Notably,heavy metal pollution and herbicide application frequently coe... Soil heavy metal contamination has emerged as a critical global environmental issue due to industrialization,posing severe threats to human health.Notably,heavy metal pollution and herbicide application frequently coexist in agricultural systems.This study reveals enantiomer-specific effects of the widely used herbicide napropamide(NAP)on plant growth and cadmium(Cd)accumulation in Arabidopsis thaliana.Compared to the control,R-NAP enhanced plant growth while S-NAP exhibited inhibitory effects.Intriguingly,R-NAP treatment increased Cd accumulation by 14%and 90%relative to the control and S-NAP,respectively.Furthermore,R-NAP significantly elevated the contents of macronutrients(nitrogen(N),phosphorus(P),potassium(K),calcium(Ca),magnesium(Mg))and micronutrients(iron(Fe),zinc(Zn))by 1.05-1.3-fold and 1.25-1.82-fold compared to the control and S-NAP treatments.Mantel test and structural equation modeling(SEM)identified significant correlations between Cd and nutrients(N,P,Fe,Zn),with N and P directly/indirectly influencing Cd accumulation via Fe/Zn regulation.Transcriptomic analysis coupled with cross-domain network modeling uncovered core genes co-regulating nutrient uptake and Cd accumulation,including NRT1.2,NRT1.5,PHT3.2,ABCC9,and YSL6.Molecular docking confirmed strong binding affinities between NAP enantiomers and these transporter proteins.Our findings demonstrate that nutrient uptake dynamics mediate herbicide-induced Cd accumulation,providing novel insights for optimizing herbicide-nutrient management to mitigate crop metal uptake in contaminated farmlands. 展开更多
关键词 Heavy metal Herbicide enantiomers Nutrient crosstalk Structural equation modeling Cross-domain network analysis
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考虑动态碳排放因子和风电预测的综合能源系统优化调度 认领 引用
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作者 张振华 曾林俊 +3 位作者 黄伟颖 徐佳妮 卿巍 李焕婷 《太阳能学报》 EI CAS CSCD 北大核心 2026年第7期18-29,共12页
为提高风能等可再生能源的利用率,进一步降低综合能源系统(IES)的碳排放水平,提出一种基于动态碳排放因子和风电预测的综合能源系统优化调度策略。首先建立综合能源系统架构,在此基础上构建基于动态碳排放因子的碳排放计量方法;其次,针... 为提高风能等可再生能源的利用率,进一步降低综合能源系统(IES)的碳排放水平,提出一种基于动态碳排放因子和风电预测的综合能源系统优化调度策略。首先建立综合能源系统架构,在此基础上构建基于动态碳排放因子的碳排放计量方法;其次,针对风力发电的波动性和间歇性造成的安全稳定运行问题,提出一种基于CNN-BiGRU-Attention的组合风电功率区间预测模型,通过比较所提模型与多种传统预测模型的风电预测效果,验证该模型的有效性和优越性;最后,以购能成本、碳交易成本和弃风成本之和最小为低碳经济运行目标,通过设置多个运行场景,验证了所提调度策略能够在降低系统运营成本的同时有效减少碳排放量。 展开更多
关键词 碳排放因子 风电功率 综合能源系统 碳交易
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极端气象条件下综合能源系统可靠性评估方法研究与展望 认领 引用
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作者 曾林俊 马宏毅 +3 位作者 肖赞 卿巍 徐佳妮 刘铮 《太阳能学报》 EI CAS CSCD 北大核心 2026年第6期78-92,共15页
全球气候变化背景下,极端高温、严寒低温冰冻、强风暴雨等极端气象事件频发,严重威胁综合能源系统(IES)的运行可靠性。基于上述事件,首先,聚焦极端气象下综合能源系统可靠性评估方法,深入剖析极端高温、严寒低温冰冻、强风暴雨3种极端... 全球气候变化背景下,极端高温、严寒低温冰冻、强风暴雨等极端气象事件频发,严重威胁综合能源系统(IES)的运行可靠性。基于上述事件,首先,聚焦极端气象下综合能源系统可靠性评估方法,深入剖析极端高温、严寒低温冰冻、强风暴雨3种极端气象对能源生产设备,涵盖发电、供热、储能设备及能源传输网络的多方面影响。其次,全面综述针对这些极端气象的综合能源系统可靠性评估方法,探讨现有方法在气象数据处理、系统耦合建模、多方法融合、韧性量化及多因素考量等方面的不足。最后,对极端气象条件下综合能源系统运行可靠性评估提出未来可能的研究方向,旨在为提升极端气象下IES可靠性评估的准确性与有效性提供一定的理论与实践参考,保障能源供应安全与稳定。 展开更多
关键词 综合能源系统 极端气象 可靠性 评估
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喷射式真空罐制冰浆的动态特性研究 认领 引用
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作者 时国华 卿伟 +1 位作者 孟子义 白丁祥 《低温与超导》 CAS 北大核心 2026年第4期67-74,共8页
针对喷射式真空罐制冰浆过程动态特性研究不足的问题,本文建立了考虑液滴传热传质与真空罐压力-温度耦合的喷射式真空罐制冰浆动态模型,数值模拟研究了喷嘴流量、罐内初始温度和初始压力对冰浆品质及系统能耗的影响。结果表明:在其他条... 针对喷射式真空罐制冰浆过程动态特性研究不足的问题,本文建立了考虑液滴传热传质与真空罐压力-温度耦合的喷射式真空罐制冰浆动态模型,数值模拟研究了喷嘴流量、罐内初始温度和初始压力对冰浆品质及系统能耗的影响。结果表明:在其他条件不变的情况下,随着喷嘴流量增大,系统准稳态温度和压力升高,冰浆含冰率降低;随着真空罐初始温度升高,冰浆含冰率降低;随着初始压力升高,冰浆含冰率增大,但达到准稳态所需时间延长。综合冰浆品质与系统能耗,在本文工况范围内,喷嘴流量4.14 L/h、初始温度269.15 K、初始压力3000 Pa时系统综合性能较优,可为喷射式真空制冰浆系统设计与运行优化提供参考。 展开更多
关键词 喷射式 真空制冰 冰浆 闪蒸 动态特性
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透析中神经肌肉电刺激对血液透析患者影响的Meta分析 认领 引用
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作者 向配君 卿伟 +1 位作者 张继权 邹兆华 《中国血液净化》 CSCD 2026年第8期684-688,共5页
目的分析透析中神经肌肉电刺激(neuromuscular electrical stimulation,NMES)对维持性血液透析(maintenance hemodialysis,MHD)患者的影响。方法检索PubMed、Web of science、Embase、Cochrane Library、中国知网、万方数据库、维普数... 目的分析透析中神经肌肉电刺激(neuromuscular electrical stimulation,NMES)对维持性血液透析(maintenance hemodialysis,MHD)患者的影响。方法检索PubMed、Web of science、Embase、Cochrane Library、中国知网、万方数据库、维普数据库和中国生物医学数据库中的相关研究,采用Revman 5.4和STATA 15.1软件进行Meta分析。结果共纳入14项研究,806例患者。Meta分析结果显示:透析中NMES可以改善MHD患者股四头肌肌力(MD=4.53,95%CI:2.91~6.15,P<0.001);亚组分析显示刺激频率≥50 Hz(MD=7.56,95%CI:5.45~9.66,P<0.001),干预时间≥30 min(MD=4.72,95%CI:2.57~6.88,P<0.001)的效果更佳。干预周期≥12周(MD=4.47,95%CI:2.63~6.30,P<0.001)和<12周(MD=4.82,95%CI:0.49~9.15,P=0.029)均能改善肌力,亚组间比较差异无统计学意义(χ2=0.020,P=0.882)。透析中NMES改善MHD患者6 min步行距离试验、计时起立行走测试和坐立试验(MD=33.71,95%CI:10.25~57.17,P=0.005;MD=-0.75,95%CI:-1.35~-0.16,P=0.013;MD=2.16,95%CI:1.51~2.80,P<0.001)等身体功能指标。2组MHD患者在握力(MD=2.11,95%CI:-0.39~4.61,P=0.099)比较差异无统计学意义。结论透析中NMES能够改善MHD患者的下肢肌力和身体功能,医务人员可以根据患者情况制定个性化干预方案,以期取得更好的临床效果。 展开更多
关键词 神经肌肉电刺激 维持性血液透析 身体功能 肌力
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基于术后2周超声血流动力学指标的自体动静脉内瘘成熟不良预测模型的构建与验证 认领 引用
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作者 曹雯 胡秀 +5 位作者 卿伟 刘明林 冯钰 张丽 许小玲 宋斌 《华西医学》 CAS 2026年第7期1077-1083,共7页
目的构建并验证基于术后2周超声血流动力学指标的自体动静脉内瘘(autogenous arteriovenous fistula,AVF)成熟不良风险预测模型。方法选择2023年3月—2025年9月德阳市人民医院肾内科首次行AVF手术的终末期肾病患者。根据术后6周成熟情... 目的构建并验证基于术后2周超声血流动力学指标的自体动静脉内瘘(autogenous arteriovenous fistula,AVF)成熟不良风险预测模型。方法选择2023年3月—2025年9月德阳市人民医院肾内科首次行AVF手术的终末期肾病患者。根据术后6周成熟情况分为成熟组和成熟不良组。收集患者基线资料及术后2周彩色多普勒超声(彩超)指标。通过LASSO回归筛选变量,多因素logistic回归分析构建列线图模型。采用受试者工作特征曲线下面积(area under the curve,AUC)、校准曲线及决策曲线分析评价模型效能。结果共纳入患者260例。其中,AVF成熟不良94例(36.2%)。LASSO回归筛选出女性、糖尿病、回流静脉内径、血管通路血流量、搏动指数、静脉深度及吻合口狭窄7个预测变量。多因素logistic回归显示,女性、糖尿病、回流静脉内径变小、血管通路血流量降低及搏动指数升高是AVF成熟不良的独立预测因素(P<0.05)。列线图模型的AUC为0.924[95%置信区间(0.893,0.956)],内部验证校正AUC为0.912。校准曲线提示校准度良好(χ2=3.703,P=0.883),决策曲线分析提示临床净获益良好。结论本模型具有高区分度与准确性,可结合术后2周常规复诊同步评估,为早期识别AVF成熟不良及个体化通路干预提供科学工具。 展开更多
关键词 自体动静脉内瘘 成熟不良 超声 血流动力学 LASSO回归 列线图 预测模型
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Potential biomarkers for the prognosis of gastrointestinal stromal tumors 认领 引用
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作者 Yue-Fang Sun Xuan-Ke Cao +1 位作者 Qing Wei Yao-Hui Gao 《World Journal of Gastrointestinal Oncology》 SCIE 2025年第4期31-35,共5页
In this editorial we comment on the article published in the recent issue of World Journal of Gastrointestinal Oncology.This study aims to explore the relationship be-tween preoperative inflammation markers and the re... In this editorial we comment on the article published in the recent issue of World Journal of Gastrointestinal Oncology.This study aims to explore the relationship be-tween preoperative inflammation markers and the recurrence of gastrointestinal stromal tumors(GIST)after surgery.It is well known that the best-documented prognostic parameters for GIST are mitotic activity,tumor size and anatomical site.Besides,mutation status represents a prognostic as well as predictive factor.This study provides a new tool for postoperative recurrence risk assessment of GIST patients by establishing a line chart prediction model,which is certificated by previous research that high platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio correlated with increased tumour sizes,more advanced tumour stages and mitotic index.However,as a retrospective study,inevitable bias exists in the results;furthermore,the sample size of this study is relatively small,in-fluencing the universality of the results.Moreover,when assessing risk rating and prognosis of GIST,some novel inflammatory makers could be taken into consi-deration,such as proenkephalin and SLITRK3.Overall,this study can offer an additional model for GIST prognosis and recurrence risk assessment,indepen-dent of the traditional prognostic factors of GIST. 展开更多
关键词 Gastrointestinal stromal tumors Prognostic parameters Inflammatory markers Recurrence risk Personalized therapy
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Endoscopic features predictive of gastric cancer in superficial lesions with biopsy-proven high grade intraepithelial neoplasia 认领 引用 被引量：17
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作者 Wei Wu Yun-Lin Wu +4 位作者 Yan-Bo Zhu Qing Wei Yan Guo Zheng-Gang Zhu Yao-Zong Yuan 《World Journal of Gastroenterology》 SCIE CAS 2009年第4期489-495,共7页
AIM:To investigate the macroscopic and clinicopathologic features of gastric cancer in patients with biopsy-suggested high grade intraepithelial neoplasia. METHODS:Patients with biopsy-confirmed gastric high grade int... AIM:To investigate the macroscopic and clinicopathologic features of gastric cancer in patients with biopsy-suggested high grade intraepithelial neoplasia. METHODS:Patients with biopsy-confirmed gastric high grade intraepithelial neoplasia were reviewed from January 2001 to March 2008.Pathologic sections were re-evaluated by two senior pathologists. Patients with an en-bloc resection of the lesion within two months after the diagnosis of high grade intraepithelial neoplasia were enrolled in the study. Clinical manifestations,endoscopic features,biopsy and surgical pathology of all patients were collected and analyzed.The data acquired were subjected to univariate and multivariate analysis. RESULTS:Seventy-two superficial gastric lesions with a pathologic diagnosis of high grade intraepithelial neoplasia based on biopsy specimens were enrolled. True high grade intraepithelial neoplasia was finally proved in 16 lesions and gastric cancer in the rest 56 lesions,most of which(96.4%)were differentiated carcinomas.The result of univariate analysis indicatedthat the size and the presence of marked ulcer plaque or scar in a superficial lesion were independently associated with gastric cancer(P<0.05),when high grade intraepithelial neoplasia was diagnosed by biopsy pathology.The results of multivariate analysis revealed the size greater than 1.5 cm[odds ratio(OR)18.400,P<0.001]and the presence of 5-odd mm ulcer plaque or scar(OR 10.000,P=0.044)were associated with gastric cancer.Accordingly,the sensitivity,specificity and negative predictive value of multivariate analysis for predicting"true high grade intraepithelial neoplasia" was 87.5%,89.3%and 96.2%,respectively. CONCLUSION:Macroscopic findings are of value in differentiation between high grade intraepithelial neoplasia and superficial gastric cancer.This may simplify patient work-up and save costs for patients and healthcare system. 展开更多
关键词 Stomach neoplasm Precancerous conditions Carcinoma in situ Endoscopy Gastrointestinal Path-ology
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Heterotrimeric G-protein is involved in phytochrome A-mediated cell death of Arabidopsis hypocotyls 认领 引用 被引量：5
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作者 Qing Wei Wenbin Zhou +3 位作者 Guangzhen Hu Jiamian Wei Hongquan Yang Jirong Huang 《Cell Research》 SCIE CAS 2008年第9期949-960,共12页
The heterotrimeric guanine nucleotide-binding protein(G-protein)has been demonstrated to mediate various signaling pathways in plants.However,its role in phytochrome A(phyA)signaling remains elusive.In this study,we d... The heterotrimeric guanine nucleotide-binding protein(G-protein)has been demonstrated to mediate various signaling pathways in plants.However,its role in phytochrome A(phyA)signaling remains elusive.In this study,we discover a new phyA-mediated phenotype designated far-red irradiation(FR)preconditioned cell death,which occurs only in the hypocotyls of FR-grown seedlings following exposure to white light(WL).The cell death is mitigated in the Gαmutant gpal but aggravated in the Gβmutant agbl in comparison with the wild type(WT),indicative of antagonistic roles of GPA1 and AGBI in the phyA-mediated cell-death pathway.Further investigation indicates that FR-induced accumulation of nonphotoconvertible protochlorophyllide(Pchlide^633),which generates reactive oxygen species(ROS)on exposure to WL,is required for FR-preconditioned cell death.Moreover,ROS is mainly detected in chloroplasts using the fluorescent probe.Interestingly,the application of H2O2 to dark-grown seedlings results in a phenotype similar to FR-preconditioned cell death.This reveals that ROS is a critical mediator for the ceil death.In addition,we observe that agb1 is more sensitive to H2O2 than WT seedlings,indicating that the G-protein may also modify the sensitivity of the seedlings to ROS stress.Taking these results together,we infer that the G-protein may be involved in the phyA signaling pathway to regulate FR-preconditioned cell death ofArabidopsis hypocotyls.A possible mechanism underlying the involvement of the G-protein in phyA signaling is discussed in this study. 展开更多
关键词 heterotrimeric G protein phytochrome A ROS cell death Pchlide
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Kinematic Control of Free Rigid Bodies Using Dual Quaternions 认领 引用 被引量：10
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作者 Da-Peng Han Qing Wei Ze-Xiang Li 《International Journal of Automation and computing》 2008年第3期319-324,共6页
This paper proposes a new type of control laws for free rigid bodies. The start point is the dual quaternion and its characteristics. The logarithm of a dual quaternion is defined, based on which kinematic control law... This paper proposes a new type of control laws for free rigid bodies. The start point is the dual quaternion and its characteristics. The logarithm of a dual quaternion is defined, based on which kinematic control laws can be developed. Global exponential convergence is achieved using logarithmic feedback via a generalized proportional control law, and an appropriate Lyapunov function is constructed to prove the stability. Both the regulation and tracking problems are tackled. Omnidirectional control is discussed as a case study. As the control laws can handle the interconnection between the rotation and translation of a rigid body, they are shown to be more applicable than the conventional method. 展开更多
关键词 Kinematic control dual quaternion omnidirectional control proportional control
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Clinicopathologic features and treatment efficacy of Chinese patients with BRAF-mutated metastatic colorectal cancer: a retrospective observational study 认领 引用 被引量：8
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作者 Xicheng Wang Qing Wei +5 位作者 Jing Gao Jian Li Jie Li Jifang Gong Yanyan Li Lin Shen 《Chinese Journal of Cancer》 2017年第11期626-634,共9页
Background: The prognostic role of the V600 E mutation of v-raf murine sarcoma viral oncogene homolog B1(BRAF)in metastatic colorectal cancer(mCRC) is well established, but the therapeutic regimen targeting this disea... Background: The prognostic role of the V600 E mutation of v-raf murine sarcoma viral oncogene homolog B1(BRAF)in metastatic colorectal cancer(mCRC) is well established, but the therapeutic regimen targeting this disease is lacking. This study aimed to analyze the clinicopathologic features of and treatment efficacy of commonly used regimens on BRAF-mutated mCRCs.Methods: We collected and reviewed the medical records of mCRC patients treated at Peking University Cancer Hospital & Institute(Beijing, China) between July 2011 and July 2016. Kirsten rat sarcoma viral oncogene homolog(KRAS),neuroblastoma RAS viral oncogene homolog(NRAS), and BRAF mutational status was assayed using direct sequencing. The details of clinicopathologic characteristics of patients and their responses to FOLFOXIRI regimen or standard therapy were obtained by reviewing the medical records. The progression-free survival(PFS) and overall survival(OS)were assessed using Kaplan-Meier analysis and compared using the log-rank test.Results: Of 1694 patients studied, 75 had BRAF exon 15 mutations. Of these 75 patients, 71 had V600 E mutation, 1 had D594 G mutation, 2 had K601 E mutation, and 1 had a novel T599_V600 insAGA alteration. No patients had KRAS or NRAS mutations. Of 63 patients with BRAFV600 E-mutated mCRC and sufficient clinical data, 27(42.9%) had right-sided colon tumors, 19(30.2%) had left-sided colon tumors, and 17(26.9%) had rectal tumors; 26(41.3%) had peritoneal metastases, and 50(79.4%) had distant lymph node metastases.The patients with BRAF K601 E-and T599_V600 insAGA-mutated tumors had similar clinicopathologic features to those with BRAFV600 E-mutated tumors. Patients with the BRAFV600 E mutation benefited more from FOLFOXIRI regimen compared with patients who underwent standard therapy(overall response rate 83.3% vs. 14.0%; median PFS 6.4 months vs. 2.8 months, P = 0.220; median OS11.0 months vs. 6.9 months, P = 0.048).Conclusions: BRAFV600 E mutations were commonly identified in right-sided tumors and showed a high incidence of peritoneal and distant lymph nodes metastases.This subtype of mCRC was characterized by short OS and unique patterns of metastasis. Compared with standard treatment regimens, the FOLFOXIRI regimen had acceptable and manageable toxicities and favorable efficacy on patients with BRAF-mutated mCRC. 展开更多
关键词 Colorectal cancer BRAF Chemotherapy Prognosis
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Analysis of Absolute Stability for Time-delay Teleoperation Systems 认领 引用 被引量：5
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作者 Qi-Wen Deng Qing Wei Ze-Xiang Li 《International Journal of Automation and computing》 2007年第2期203-207,共5页
In this paper, a new bilateral control algorithm based on absolute stability theory is put forward, which aims at the time-delay teleoperation system with force feedback from the slave directly. In the new control alg... In this paper, a new bilateral control algorithm based on absolute stability theory is put forward, which aims at the time-delay teleoperation system with force feedback from the slave directly. In the new control algorithm, the delay-dependent stability, instead of delay-independent stability, is taken as the aim of control design. It improves the transparency of the system at the price of unnecessary stability. With this algorithm, the time-delay teleoperation systems have good transparency and stability. A simulation system is established to verify the effect of this algorithm. 展开更多
关键词 Time-delay stability transparency absolutely stability delay-dependent stability.
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Research progress on the MYB transcription factors in tropical fruit 认领 引用 被引量：3
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作者 Yanshu Zhang Yi Xu +7 位作者 Dongmei Huang Wenting Xing Bin Wu Qing Wei Yongyan Xu Rulin Zhan Funing Ma Shun Song 《Tropical Plants》 2022年第1期32-46,共15页
Tropical fruits,such as bananas,passion fruit,mangoes,and lychees,are rich in vitamins,flavonoids and non-flavonoid phenols,and are the healthiest way to intake bioactive compounds in one's daily diet.Coupled with... Tropical fruits,such as bananas,passion fruit,mangoes,and lychees,are rich in vitamins,flavonoids and non-flavonoid phenols,and are the healthiest way to intake bioactive compounds in one's daily diet.Coupled with their unique taste,tropical fruits are becoming more increasingly popular.The production of bananas is second only after grapes,while other tropical fruit are limited by the planting environment,resulting in a relatively low planting area and yield.With the improvement in breeding technology and planting technology,the development of tropical fruit crops will have broad prospects.MYB plays a major regulatory role in several biological processes,including growth and development of plants,quality formation,and stress resistance.There is a comparatively junior level of research on tropical fruit crops compared to grain fruit and model plants.Despite the progress that has been made in the development of molecular biology methods that can transform the genetic makeup of tropical fruit crops,the functional understanding of the multiple MYB genes is still in its initial stages.This paper aims to review the current status of the research on the development of these genes and their prospects.It is expected to provide a reference for the study of MYB transcription factors in tropical fruit crops and to provide new ideas for the functional resolution of MYB transcription factors in different biological processes. 展开更多
关键词 crops planting tropical
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Implications of the mismatch repair-deficient status for the management of colorectal cancers 认领 引用 被引量：1
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作者 Qing Wei Lin Shen 《Oncology and Translational Medicine》 CAS 2017年第1期20-24,共5页
Although the majority of colorectal cancer(CRC) cases develop through the CIN pathway, approximately 15% of cases are caused by the hypermutation known as microsatellite instability(MSI) that is a consequence of defic... Although the majority of colorectal cancer(CRC) cases develop through the CIN pathway, approximately 15% of cases are caused by the hypermutation known as microsatellite instability(MSI) that is a consequence of deficient(d) DNA mismatch repair(MMR). d MMR CRCs have distinct phenotypic characteristics compared with microsatellite stable(MSS) tumors. MSI CRC is associated with an earlier stage at diagnosis and improved stage-specific prognosis, although this is controversial in stage IV patients. Current evidence supports the use of adjuvant chemotherapy with fluoropyrimidine plus oxaliplatin for stage III d MMR CRC. The distinctive genomic characterization and expression profiling of d MMR CRC paves the way for tailored immunotherapies. This is supported by recent studies that highlighted the efficacy of immunotherapy in d MMR CRC. Here, we describe the molecular aspects of the MMR system and discuss the associations of MMR-deficient/MSI-H status with clinical management, especially for patients with metastatic CRC. 展开更多
关键词 colorectal cancer (CRC) mismatch repair microsatellite instability immunotherapy
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Geleophysic dysplasia caused by a mutation in FBN1:A case report 认领 引用 被引量：4
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作者 Ying Tao Qing Wei +1 位作者 Xun Chen Guang-Min Nong 《World Journal of Clinical Cases》 SCIE 2021年第24期7175-7180,共6页
BACKGROUND Geleophysic dysplasia(GD)presents the characterized clinical manifestations of acromelic dysplasia,including extremely short stature,short limbs,small hands and feet,stubby fingers and toes,joint stiffness ... BACKGROUND Geleophysic dysplasia(GD)presents the characterized clinical manifestations of acromelic dysplasia,including extremely short stature,short limbs,small hands and feet,stubby fingers and toes,joint stiffness and others.It is clinically distinct from the other acromelic dysplasia in terms of symptoms such as cardiac valvular abnormalities,progressive hepatomegaly and tracheal stenosis.CASE SUMMARY We report on a Chinese 9-year-old girl with GD with the c.5243G>T(p.C1748F)mutation in FBN1(fibrillin 1,OMIM 134797).She was born in Guangxi Zhuang Autonomous Region of China.The patient presented with typical clinical features of GD and recurrent respiratory tract infections over 6 years.Laboratory studies and chest computed tomography(CT)scan indicated bronchopneumonia.Her echocardiography revealed mild mitral valve thickening with regurgitation.Laryngopharyngeal CT and electronic bronchoscopy revealed severe glottic stenosis.Echocardiography examination displayed mild mitral valve thickening and regurgitation.Ophthalmic examination did not reveal myopia or lens dislocation.Treated with ceftriaxone sodium and methylprednisolone sodium succinate for injection as well as methylprednisolone orally,patient’s symptoms had improved.CONCLUSION GD is a rare genetic condition that can cause life-threatening cardiovascular and respiratory problems.This study also found that the identified genotype of GD could be related to different clinical phenotypes. 展开更多
关键词 Fibrillin 1 Geleophysic dysplasia Acromelic dysplasia Short stature Tracheal stenosis Case report
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Effect of Different Drying Methods on the Volatile Compounds Jinmudan Oolong Tea 认领 引用 被引量：2
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作者 Hui-Jing Xu Ying Wu +3 位作者 Qing Wei Fei-Long Cui Jing Zhu Ling-Yun Zhang 《茶叶》 2013年第4期362-369,共8页
Jinmudan,a new tea variety from Fujian Province has an excellent quality with a unique aroma like magnolia frogrance.To monitor the changes in the tea volatile compounds during the Jinmudan Oolong tea manufacturing(dr... Jinmudan,a new tea variety from Fujian Province has an excellent quality with a unique aroma like magnolia frogrance.To monitor the changes in the tea volatile compounds during the Jinmudan Oolong tea manufacturing(drying) process,the volatiles of tea samples were extracted and analyzed.Characteristic volatile compounds in Jinmudan Oolong tea were nerolidol,α-farnesene,linolenic acid,palmitic acid,indole,phenylacetaldehyde,cisjasmone,β-phenylethanol,etc.The content of nerolidol was the highest in four tested samples.The composition of the volatile compounds in microwave drying sample was simple,but its concentration was high,in which the main volatile compounds were alcohols and esters.The processing with combination of traditional drying craft and modern aroma-improvement technique could obviously improve the tea aroma,especially in level of epoxy linalool and jasmine lactone. 展开更多
关键词 挥发性化合物 干燥方法 乌龙茶 茶叶香气 橙花叔醇 茶叶品种 苯基乙醇 测试样本
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Analysis of Volatile Compounds of Jinmudan Oolong Tea by Different Wrapping-Twisting 认领 引用
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作者 Qing Wei Ying Wu +3 位作者 Fei-Long Cui Jing Zhu Hui-Jing Xu Ling-Yun Zhang 《茶叶》 2013年第4期401-405,共5页
In this study,the volatile compounds in four kinds of Jinmudan Oolong tea were extracted and analyzed by simultaneous steam distillation and extraction(SDE) and gas chromatography-mass spectrometry(GC-MS),respectively... In this study,the volatile compounds in four kinds of Jinmudan Oolong tea were extracted and analyzed by simultaneous steam distillation and extraction(SDE) and gas chromatography-mass spectrometry(GC-MS),respectively.The relative contents of the chemical constituents in the volatile components were quantified by peak area normalization and NIST database.A total of 93 volatile components were identified,46 for sample 1,56 for sample 2,45 for sample 3 and 30 for sample 4.Alcohols and esters were the most abundant volatiles in Jinmudan Oolong tea.Palmitic acid,nerolidol,2-phenylethanol,phytol,cis-5-ethenyltetrahydro-.α,α-5-trimethyl-2-furanmethanol,2,2,6-trimethyl-6-ethenyltetrahydro-2h-pyran-3-ol,a-farnesene,eicosane,hexadecane,indole,β-phenethyl hexanoate,β-phenethyl hexanoate,methyl palmitate,benzoic acid,2-phenylethyl ester,tetrahydro-6-(cis-2-pentenyl)-2h-pyran-2-one and cis-jasmone were in all of the samples.Nerolidol was shown to be the aroma components with the highest content in Jinmudan Oolong tea,which accounted for 26.61%,36.89%,36.89%and 36.89%. 展开更多
关键词 挥发性成分 乌龙茶 包装 挥发性化合物 棕榈酸酯 水蒸气蒸馏 GC-MS 气相色谱
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Volatile Compounds in Two Camellia chrysantha(Hu)Tuyama Species 认领 引用
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作者 Fei-long Cui Qing Wei Ling-Yun Zhang 《茶叶》 2013年第4期294-298,共5页
In the study,the volatile compounds in two Camellia chrysantha(Hu) Tuyama species were extracted and analysed by simultaneous steam distillation and extraction(SDE) and gas chromatography mass spectrometry(GCMS),respe... In the study,the volatile compounds in two Camellia chrysantha(Hu) Tuyama species were extracted and analysed by simultaneous steam distillation and extraction(SDE) and gas chromatography mass spectrometry(GCMS),respectively.The relative contents of the chemical constituents in the volatile components were quantified by peak area normalization and NIST database.A total of 60 volatile components were identified,45 for Camellia nitidissima and 26 for Camellia euphlebia.Aldehydes and acids were the most dominant volatiles in Camellia nitidissima,but for Camellia euphlebia there were hydrocarbons and ketones.Hexanoic acid,4-(2,6,6-trimethyl-1-cyclohexenyl)-3-buten-2-one,cis-2-decenal,4-[2,2,6-trimethyl-7-oxabicyclo[4.1.0]hept-1-yl]-3-buten-2-one,phenylacetaldehyde,eicosane,alpha-ionone,geranylacetone 2,6-di-tert-butyl-4-methylphenol,7,9-di-tertbutyl-1-oxaspiro[4,5]deca-6,9-diene-2,8-dioi and tetradecanal were both in two Camellia chrysantha(Hu)Tuyama species. 展开更多
关键词 挥发性成分 金花茶 挥发性化合物 α-紫罗兰酮 水蒸气蒸馏 GC-MS 香叶基丙酮 气相色谱
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六师联动模式在慢性肾脏病延续护理中的应用 认领 引用 被引量：13
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作者 卿伟 陈飞 +2 位作者 唐利群 邹兆华 赵媛媛 《护理研究》 北大核心 2019年第18期3141-3144,共4页
[目的]探索六师联动模式在慢性肾脏病延续护理中的应用效果。[方法]选取2016年3月-2017年10月在肾内科就诊的慢性肾脏病病人120例,按照不同护理方法将病人分为两组各60例。对照组给予常规出院指导和电话随访,观察组在常规出院指导和电... [目的]探索六师联动模式在慢性肾脏病延续护理中的应用效果。[方法]选取2016年3月-2017年10月在肾内科就诊的慢性肾脏病病人120例,按照不同护理方法将病人分为两组各60例。对照组给予常规出院指导和电话随访,观察组在常规出院指导和电话随访的基础上实施六师联动模式进行延续护理。出院时、出院后6个月分别进行两组病人治疗依从性、生活质量和肾功能指标的测量和比较。[结果]观察组病人出院后6个月治疗依从性评分为(45.20±4.20)分,对照组为(38.65±9.10)分,两组比较差异有统计学意义(P<0.05);观察组病人出院后6个月生活质量总分为(76.37±7.91)分,对照组为(63.82±5.34)分,两组比较差异有统计学意义(P<0.05);观察组病人出院后6个月血尿素氮、血肌酐、胱抑素C分别为(11.49±2.20)mmol/L、(416.42±30.14)μmol/L、(3.96±0.25)g/L,对照组分别为(15.09±2.57)mmol/L、(466.80±28.19)μmol/L、(4.40±0.35)g/L,两组比较差异均有统计学意义(P<0.05)。[结论]六师联动模式在慢性肾脏病延续护理中的应用,有助于提高病人的治疗依从性和生活质量,延缓疾病进展。 展开更多
关键词 六师联动模式 慢性肾脏病 延续护理 治疗依从性 生活质量 尿素氮 肌酐 胱抑素C
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