Aqueous zinc-ion batteries(AZIBs)hold great promise for safe and sustainable energy storage,but their commercialization is impeded by severe Zn dendrite growth and interfacial instability.To address these challenges,w...Aqueous zinc-ion batteries(AZIBs)hold great promise for safe and sustainable energy storage,but their commercialization is impeded by severe Zn dendrite growth and interfacial instability.To address these challenges,we propose a defect engineering strategy employing ultrafine ZnAl2O4(ZAO)nanoparticles(~5 nm)with oxygen vacancy defects as an artificial protective layer for Zn anodes.Synthesized via a scalable coprecipitation approach,the ZAO layer demonstrates exceptional Zn2+affinity and rapid ion diffusion,enabling uniform Zn deposition and suppressing parasitic reactions.Remarkably,the ZAO@Zn symmetric cell achieves an unprecedented cycling stability of 3600 h at 20 mA cm-2,outperforming most reported Zn anodes modified with metal oxyacid compounds.Moreover,the assembled ZAO@Zn//MnO2full cell retains a capacity of 166.5 mAh g-1after 1000 cycles at 2 A g-1.This work highlights that engineering oxygen vacancies in the ZAO layer is an effective strategy to enhance the performance and longevity of Zn anodes in AZIBs,paving the way for more reliable and efficient energy storage solutions.展开更多
The third molar is the most developmentally delayed of the permanent teeth and has the highest incidence of pericoronitis and odontogenic space infections.Impacted third molars significantly increase the risk of perio...The third molar is the most developmentally delayed of the permanent teeth and has the highest incidence of pericoronitis and odontogenic space infections.Impacted third molars significantly increase the risk of periodontitis,dental caries,and external root resorption of adjacent second molars.Third molars are associated with complex surgical procedures,and treatment decisions and clinical management of third molars in this context remain controversial.This expert consensus was generated by oral surgeons and related specialists,who synthesized the current evidence-based literature and contemporary clinical practices.This consensus addresses critical considerations:the developmental trajectory and impaction characteristics of third molars,clinical and radiographic examinations of third molars,classification of impacted third molars,adverse effects of impacted third molars on oral health,indications for extraction,preoperative preparation for impacted third molar removal,anesthetic choices for impacted third molar surgery,recommended surgical protocol for impacted third molar removal,application of implant materials in alveolar sockets,management of common severe complications in impacted third molar extraction,and functional utilization of impacted third molars.Based on a comprehensive expert deliberation,this consensus provides evidence-based clinical guidance and standardized protocols for dental practitioners in the context of third molar management and therapeutic decision-making.展开更多
Piston pumps are extensively employed in the industrial and aerospace sectors,particularly in applications that demand high-pressure operation and precise flow regulation.However,the inherent structural complexity of ...Piston pumps are extensively employed in the industrial and aerospace sectors,particularly in applications that demand high-pressure operation and precise flow regulation.However,the inherent structural complexity of these components,coupled with their frequent exposure to adverse operating conditions,leads to various forms of surface degradation in friction pair elements.To address these challenges,researchers have pursued the development of advanced coating technologies aimed at enhancing surface hardness,reducing friction coefficients,and improving wear resistance.These coatings typically include metallic coatings,ceramic coatings,and diamond-like carbon(DLC)coatings,along with more cutting-edge yet highly promising high-entropy alloy(HEA)coatings.As a novel class of materials,HEA coatings hold considerable potential to overcome the inherent limitations of conventional coating systems.This review provides a comprehensive overview of recent advances in piston pump coating technologies,with particular emphasis on deposition methodologies,microstructural characteristics,and tribological performance.By establishing microstructure-property relationships within these coating systems,this study proposes future research directions for optimizing surface engineering approaches in hydraulic pump applications.展开更多
Ensuring the long-term and stable operation of mechanical equipment has been a research emphasis with the development of aerospace and polar exploration,which necessitates the prepared materials with high mechanical s...Ensuring the long-term and stable operation of mechanical equipment has been a research emphasis with the development of aerospace and polar exploration,which necessitates the prepared materials with high mechanical strength as well as excellent wear resistance[1].The traditional lubricant is widely acknowledged to be susceptible to evaporation or decomposition under extreme conditions,necessitating the deposition of a protective thin film on critical mechanical parts’surfaces to enhance their mechanical and tribological properties[2,3].展开更多
CoCrNi medium-entropy alloy has demonstrated remarkable mechanical properties,suggesting its potential as a structural material.Nevertheless,the challenge lies in achieving an elusive combination of high hardness and ...CoCrNi medium-entropy alloy has demonstrated remarkable mechanical properties,suggesting its potential as a structural material.Nevertheless,the challenge lies in achieving an elusive combination of high hardness and inherent self-lubrication on the worn surface,which is crucial for attaining exceptional tribological performance in medium-entropy alloy(MEA).This study reports the preparation of a novel CoCrNi-based self-lubricating composite by powder metallurgy,which is reinforced simultaneously with Ag solid lubricating phase and SiC ceramic particles.During the sintering process,SiC decomposes to form high hardness in situ Cr23C6,enabling the composite to achieve high load-bearing capacity.During the sliding process,thick and dense Ag self-lubricating film is successfully achieved due to the mechanical and thermal effects.The protective tribo-layer effectively mitigates surface stress concentration induced by wear,thereby inhibiting surface coarsening and substantially enhancing the tribological performance.The results showed that compared with CoCrNi MEA,the wear rate and friction coefficient of CoCrNi/SiC/Ag composite are reduced by 88.1%and 32.8%,respectively,showing superior tribological properties over most MEA-based self-lubrication composites.This study further elucidates the wear mechanism of CoCrNi/SiC/Ag composite,providing a new strategy for developing self-lubricating materials with excellent comprehensive performance,which overcomes the inherent trade-off between wear resistance and lubrication.展开更多
Guided bone regeneration in the alveolar bone relies on the colonization and differentiation of immune cells within the defect area.The absence of osteoinductive and osteoimmune properties of currently available scaff...Guided bone regeneration in the alveolar bone relies on the colonization and differentiation of immune cells within the defect area.The absence of osteoinductive and osteoimmune properties of currently available scaffolds hinders to achieve optimal repair outcomes in clinical settings.Thus,we aimed to enhance the bone repair ability of polycaprolactone(PCL)scaffolds by incorporating osteoinductive amorphous calcium phosphate(ACP)with immune-regulating zinc ions(ACP(Zn),ACZP),to create a favorable immunomodulatory microenvironment.After one day of co-culture with PCL-ACZP,the spreading area of macrophage cells was significantly higher than that from the original PCL scaffold.Additionally,over 32.1%of macrophages exhibited M2 polarization within three days of co-culture.The PCLACZP/macrophage-conditioned medium significantly boosted osteogenic gene expression in MC3T3-E1 cells.After eight weeks of implantation in a rat femoral condyle defect,the BV/TV from the PCL-ACZP group reached 32.9%,1.4 times of that from the PCL group.Furthermore,the PCL-ACZP-GelMA biphasic module as prepared successfully achieved complete regeneration of three-walled alveolar bone defects in rabbits,resulting in arch-shaped alveolar bone repair and providing greater convenience in the clinical settings.This study showcased the effectiveness of PCL-ACZP-GelMA biphasic module as bioactive scaffolds in the morphological restoration of alveolar bone.展开更多
Zwitterionic materials with covalently tethered cations and anions have great potential as electrolyte additives for aqueous Znion batteries(AZIBs)owing to their appealing intrinsic characteristics and merits.However,...Zwitterionic materials with covalently tethered cations and anions have great potential as electrolyte additives for aqueous Znion batteries(AZIBs)owing to their appealing intrinsic characteristics and merits.However,the impact of cationic and anionic moieties within zwitterions on enhancing the performance of AZIBs remains poorly understood.Herein,three zwitterions,namely carboxybetaine methacrylate(CBMA),sulfobetaine methacrylate(SBMA),and 2-methacryloyloxyethyl phosphorylcholine(MPC),were selected as additives to investigate their different action mechanisms in AZIBs.All three zwitterions have the same quaternary ammonium as the positively charged group,but having different negatively charged segments,i.e.,carboxylate,sulfonate,and phosphate for CBMA,SBMA,and MPC,respectively.By systematical electrochemical analysis,these zwitterions all contribute to enhanced cycling life of Zn anode,with MPC having the most pronounced effect,which can be attributed to the synergistic effect of positively quaternary ammonium group and unique negatively phosphate groups.As a result,the Zn//Zn cell with MPC as additive in ZnSO4electrolyte exhibits an ultralong lifespan over 5000 h.This work proposes new insights to the future development of multifunctional zwitterionic additives for remarkably stable AZIBs.展开更多
Nanocrystalline Ce-based rare earth(RE)-Fe-B alloys exhibit relatively good hard magnetic properties and high performance-cost ratio,but their properties deteriorate seriously after hot deformation(HD).Here,we present...Nanocrystalline Ce-based rare earth(RE)-Fe-B alloys exhibit relatively good hard magnetic properties and high performance-cost ratio,but their properties deteriorate seriously after hot deformation(HD).Here,we present a simplified one-step HD process for preparing anisotropic Ce-based Ce25.88La2.85Y4.56Fe65.73B0.98(wt%)magnets.The precursor of nanocrystalline powders is first compacted inside a copper tube,and then the powders with the tube are deformed together to achieve magnetic anisotropy.Compared with the conventional two-step HD magnet,i.e.,hot pressing followed by HD,one-step HD significantly increased the coercivity from 1.6 to 3.0 kOe,and the maximum magnetic energy product was improved from 3.7 to 4.8 MGOe.The microstructure characterization indicates that one-step HD can not only produce a more desirable microstructure,characterized by well-aligned platelet-shaped grains with reduced aspect ratio but also greatly inhibit the formation of coarse grain(CG)region.Both of them have been confirmed to be beneficial to enhancing coercivity by micromagnetic simulations.Our results thus demonstrate that the simplified one-step HD process offers a promising approach to developing high-performance anisotropic Ce-based magnets.展开更多
Based on data from the investigation in Jiaozhou bay waters in 1979, the distribution, pollution source and seasonal variation of PHC in Jiaozhou Bay are analyzed. It is showed that in Jiaozhou bay PHC contents arrive...Based on data from the investigation in Jiaozhou bay waters in 1979, the distribution, pollution source and seasonal variation of PHC in Jiaozhou Bay are analyzed. It is showed that in Jiaozhou bay PHC contents arrived the national Category Ⅱof the water quality standard during this year. In summer in the bay the pollution of PHC was heavy, while relatively light in spring. In the coastal waters in the east and the northeast of the bay, the PHC contents in spring surpassed the national Category Ⅱ, and surpassed the national Category Ⅲ. In the coastal waters, in the northeast of the bay, the change of the PHC contents formed the grads: the contents presented the falling trend from the big one to the small, which unveiled that the PHC souce in the bay mainly came from the discharge of the industrial waste water and living sewage.展开更多
Organic-inorganic hybrid solar cells consisting of organic conjugated materials and inorganic quantum dots(QDs)have been of great interest during the past two decades.However,it is still challenging to select desired ...Organic-inorganic hybrid solar cells consisting of organic conjugated materials and inorganic quantum dots(QDs)have been of great interest during the past two decades.However,it is still challenging to select desired organic functional materials for fabricating hybrid films to maximize their photovoltaic performance.Herein,we report the synthesis of three narrow bandgap non-fullerene conjugated polymers and further demonstrate the importance and impact of polymer crystallinity in tuning the organic-inorganic hybrid interface towards improved photovoltaic performance.In specific,we develop an organic-inorganic hybrid active layer using a newly synthesized polymer with relatively weaker crystallinity and FAPbI3QDs,enabling complementary absorption and favorable interface/morphology for efficient charge separation and transport.The champion PCDOT-T/FAPbI3QD hybrid device achieves a record-high efficiency of 13.11%based on the one-step coating organic/QD hybrid bulk heterojunction blend,which is significantly improved relative to the semi-crystalline polymer PYIT-based hybrid device(11.23%)and pristine QD(10.51%).We believe these findings would provide new insight into the organic/QD interface to construct desired hybrid films for high-performing optoelectronic applications.展开更多
Enhancing the hard magnetic properties of Ce-Fe-B-based magnets remains a significant challenge due to the REFe2(RE=rare earth) phase precipitation.Here,Y substitution for Ce and Cu doping is employed to suppress R...Enhancing the hard magnetic properties of Ce-Fe-B-based magnets remains a significant challenge due to the REFe2(RE=rare earth) phase precipitation.Here,Y substitution for Ce and Cu doping is employed to suppress REFe2 formation and optimize the intrinsic properties of RE2Fe14B phase.Partial substitution of Ce by Y significantly improves the magnetic properties and thermal stability of(Ce1-xYx)17Fe78B6(x=0-0.8,at%) alloys.First-principles calculations reveal that Y substitution destabilizes the REFe2 phase,thus inhibiting its formation.Notably,at substitution levels exceeding x> 0.4,the residual REFe2 phase undergoes a magnetic transition from paramagnetic to ferromagnetic behavior.Subsequent Cu doping in(Ce0.5Y0.5)17Fe77.6Cu0.4B6 alloys further destabilizes the REFe2 phase and transforms aggregated bulk phases into intergranular structures.This microstructural modification facilitates magnetic decoupling,yielding enhanced magnetic properties with coercivity of 435 kA m-1,remanence of 0.67 T and maximum energy product of 65.2 kJ m-3.Micromagnetic simulations confirm the positive roles of tailoring the distribution and magnetic behavior of the REFe2 phase in enhancing coercivity.Finally,the nanocrystalline(Ce0.5Y0.5)17Fe77.6-Cu0.4B6 powders synthesized via industrial overquenching/annealing demonstrate a high performance/cost ratio,highlighting their significant potential for cost-effective permanent magnet applications.展开更多
Non-small cell lung cancer (NSCLC), as the leading cause of cancer-related deaths, poses a serious health issue worldwide1,according to the Global Cancer Statistics 2022. Approximately 30% of NSCLC patients are diagno...Non-small cell lung cancer (NSCLC), as the leading cause of cancer-related deaths, poses a serious health issue worldwide1,according to the Global Cancer Statistics 2022. Approximately 30% of NSCLC patients are diagnosed at an advanced or metastatic stage with a 5-year overall survival (OS) rate ranging from 7%-18%2. Unlike localized NSCLC, which can be treated with curative intent, patients with metastatic NSCLC typically undergo systemic treatment to delay progression and prolong survival.展开更多
Depression is a prevalent neuropsychiatric disorder characterized by persistent sadness,anhedonia,guilt,fatigue,and impaired concentration.Although pharmacotherapy and psychotherapy can be effective,their utility is l...Depression is a prevalent neuropsychiatric disorder characterized by persistent sadness,anhedonia,guilt,fatigue,and impaired concentration.Although pharmacotherapy and psychotherapy can be effective,their utility is limited by adverse effects and significant inter-individual variability.Non-pharmacological therapies from traditional medicine have emerged as promising adjuncts owing to their favorable safety profiles,minimal side effects,and high patient compliance.These therapies,including acupoint stimulation,meditation,and yoga,produce antidepressant effects by reducing neuroinflammation,modulating neurotransmitter release,enhancing neuroplasticity,and regulating the gut-brain axis.This review summarizes clinical applications and mechanistic insights of traditional medicine’s non-pharmacological therapies for depression,providing a scientific rationale for their integration into comprehensive management.展开更多
The Jianglang Dome has integral tectonostratigraphic units and contains a suite of high-grade stratiform Cu deposits.However,the formation mechanism of this dome and genetic model of Cu mineralization remain a matter ...The Jianglang Dome has integral tectonostratigraphic units and contains a suite of high-grade stratiform Cu deposits.However,the formation mechanism of this dome and genetic model of Cu mineralization remain a matter of debate.The resolution of these problems hinges on the presence of magmatic intrusions in the core.Here,we report bulk geochemical and zircon U-Pb data of a newly discovered syenite intrusion as well as chalcopyrite Re-Os dating results.We aim to explore genesis of the Jianglang Dome,genetic model of the stratiform Cu deposits,and rare metal mineralization potential of the syenite intrusion.The dated syenite sample yields an emplacement age of 207.1±2.0 Ma,which matches post-collisional extension in the Songpan-Ganze Orogen.The syenite rocks have average high(Zr+Nb+Ce+Y)concentrations of 512 ppm,10000.Ga/Al ratios of 3.97,and crystallization temperatures of 827°C,together with low Mg#values of 1.73;they fi t the A-type granitoid defi nition and a crustal origin.Chalcopyrite separates yield a Re-Os isochron age of 207.1±5.3 Ma,which markedly postdates the formation age of their orehosting rocks(the Liwu Group,ca.553 Ma).Our new age determination,together with previous chalcopyrite Re–Os isochron age of ca.151.1 Ma and sulfi de sulfur isotope(δ34SV-CDT=8.7‰–5.6‰)and tourmaline boron isotope(δ11B=−15.47‰to−5.91‰)data,confi rms multistage epigenetic Cu mineralization related to magmatic-hydrothermal fl uids.Compared with regional ca.209–207 Ma fertile granitoids,the studied syenite intrusion shows unevolved and barren affi nities and negligible rare metal mineralization potential.Combined with residual gravity low anomalies in the core of the Jianglang Dome,which suggest a large deepseated granitic batholith,we prefer thermal doming resulting from magma-induced uplift for the nature of this dome.展开更多
Objective:To improve the efficacy of Astragalus membranaceus(Fisch.)Bunge(A.membranaceus,Huang Qi),and to further develop and utilize it,fermentation technology was applied to the stem and leaf of A.membranaceus to en...Objective:To improve the efficacy of Astragalus membranaceus(Fisch.)Bunge(A.membranaceus,Huang Qi),and to further develop and utilize it,fermentation technology was applied to the stem and leaf of A.membranaceus to enhance its immune function.Methods:In this study,we fermented A.membranaceus stem and leaf(ASL)with probiotics and inves-tigated its immune function.Firstly,we screened suitable strains for ASL fermentation and optimized the fermentation process.Secondly,we determined the antioxidant capacity of fermented ASL and its effect on inflammation in mouse monocyte-macrophage cell.Finally,the immunocompromised mice were treated with fermented ASL to investigate the changes in their immune ability.Results:Among the 10 selected probiotics,Lactobacillus plantarum was the most suitable strain for ASL fermentation.After optimization of the fermentation process,the content of saponins in fermented ASL was significantly increased.The fermented ASL exhibited strong anti-inflammatory and antioxidant activities in vitro.The in vivo immune efficacy improved by promoting the development of the spleen and thymus,as well as raising the immunoglobulin M,tumor necrosis factor-α,and interleukin-1β levels of in the serum.Conclusion:This study contributes to developing the non-medicinal parts of A.membranaceus,expands its medicinal resources,highlights the potential of fermentation technology to enhance these parts,and provides a reference for further development.Based on this approach,we can promote using non-me-dicinal parts of herbal medicines,minimize drug waste,and offer a reference for developing non-me-dicinal components in Chinese herbal medicines.展开更多
BACKGROUND Gastrointestinal surgical acute abdomen conditions.These conditions not only cause significant suffering to patients but also increase psychological stress for both patients and their families.AIM To invest...BACKGROUND Gastrointestinal surgical acute abdomen conditions.These conditions not only cause significant suffering to patients but also increase psychological stress for both patients and their families.AIM To investigate communication characteristics in gastrointestinal surgical acute abdomen cases(such as appendicitis and pancreatitis)and explore optimization pathways.METHODS Eighty-two patients with gastrointestinal surgical acute abdomen(including appendicitis and pancreatitis)admitted to the hospital between November 2022 and June 2024 were selected.Physician-patient communication characteristics were analyzed.Patients were randomly divided into two groups(41 each)using a random draw method.The control group received conventional physician-patient communication.The observation group received an optimized communication model based on the conventional method.The two groups were compared for treatment efficacy and outcomes,psychological status,coping strategies,sleep quality,and compliance.RESULTS Significant differences were observed between the two groups in terms of time to ambulation and duration of hospital stay(P0.05).After the intervention,the psychological status scale scores in both groups decreased significantly(P<0.05),with significant differences between the groups(P<0.05).Following the intervention,the facing subscale scores of the medical coping questionnaire increased,while the avoidance and submission subscale scores decreased(P<0.05),with significant differences between the groups(P<0.05).The observation group had lower scores on the sleep quality scale(P<0.05).The compliance rate was higher in the observation group(97.56%vs 80.49%,P<0.05).CONCLUSION Physician-patient communication presented contradictions between professionalism and laymen’s expression and rigid communication methods.Optimizing communication models can improve sleep quality,coping strategies,patient compliance,and treatment outcomes and reduce negative emotions.展开更多
Rural education in China faces significant challenges,including limited resources,declining student enrollment,and frequent school closures.This paper examines the educational leadership and management strategies empl...Rural education in China faces significant challenges,including limited resources,declining student enrollment,and frequent school closures.This paper examines the educational leadership and management strategies employed by Simin Primary School,a century-old rural institution in Zhuji City,which has successfully revitalized its community and attracted students through the innovative practice of nature education.By leveraging local cultural and environmental resources,the school has established a sustainable model for small rural schools.展开更多
INTRODUCTION Hepatitis B is one of the common infectious diseases,which severely impairs the health of the people in our country and has close relationship
Objective: To evaluate the efficacy and safety of nedaplatin/gemcitabine (NG) and carboplatin/gemcitabine (CG) in the management of untreated advanced non-small cell lung cancer (NSCLC). Methods: Sixty-two pat...Objective: To evaluate the efficacy and safety of nedaplatin/gemcitabine (NG) and carboplatin/gemcitabine (CG) in the management of untreated advanced non-small cell lung cancer (NSCLC). Methods: Sixty-two patients with previously untreated advanced NSCLC were recruited between June 2006 and November 2007. Subjects were randomly assigned to the NG arm (n=30) and the CG arm (n=32). Only patients (24 and 25 in the NG and CG arms, respectively) who completed 〉2 chemotherapy cycles were included in the data analysis. The primary outcome measure was the objective response rate (ORR). The secondary outcome measures included progression-free survival (PFS), overall survival (OS) and adverse events. Results: There were no statistically significant differences in the efficacy measures (ORR, P=0.305; median PFS, P=0.298, median OS, P=0.961) or in the major adverse events (grade 3/4 neutropenia, P=0.666; grade 3/4 anemia, P=0.263; grade 3/4 thrombocytopenia, P=0.222) between the two treatment arms. However, there was a trend towards higher ORR (37.5% vs. 24.0%), longer PFS (6.0 vs. 5.0 months), and less adverse events in the NG arm. Conclusion: NG regimen seems to be superior over CG regimen for advance NSCLS, but further investigation is needed to validate this superiority.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.22209143)Jiangsu Carbon Peak Carbon Neutralization Science and Technology Innovation Special Fund(Grant No.BE2022605)+1 种基金the Fundamental Research Funds for the Central Universitiesthe support from the Youth Fund Project of GRINM。
摘要Aqueous zinc-ion batteries(AZIBs)hold great promise for safe and sustainable energy storage,but their commercialization is impeded by severe Zn dendrite growth and interfacial instability.To address these challenges,we propose a defect engineering strategy employing ultrafine ZnAl2O4(ZAO)nanoparticles(~5 nm)with oxygen vacancy defects as an artificial protective layer for Zn anodes.Synthesized via a scalable coprecipitation approach,the ZAO layer demonstrates exceptional Zn2+affinity and rapid ion diffusion,enabling uniform Zn deposition and suppressing parasitic reactions.Remarkably,the ZAO@Zn symmetric cell achieves an unprecedented cycling stability of 3600 h at 20 mA cm-2,outperforming most reported Zn anodes modified with metal oxyacid compounds.Moreover,the assembled ZAO@Zn//MnO2full cell retains a capacity of 166.5 mAh g-1after 1000 cycles at 2 A g-1.This work highlights that engineering oxygen vacancies in the ZAO layer is an effective strategy to enhance the performance and longevity of Zn anodes in AZIBs,paving the way for more reliable and efficient energy storage solutions.
基金Capital's Funds for Health Improvement and Research(2024-2-2142,Jian Zhou)Beijing Hospitals Authority Clinical medicine Development of special funding support(YGLX202535,Jian Zhou)Hu Bei Association of Higher Education,Society Community Construction Project(Teaching Application of AI-Assisted 3D CBCT Reconstruction Combined with PVC Resin-Based Dental Model Reconstruction in Root Removal First strategy for Impacted Third Molar Extraction,2024XD218,Rui Sun)。
摘要The third molar is the most developmentally delayed of the permanent teeth and has the highest incidence of pericoronitis and odontogenic space infections.Impacted third molars significantly increase the risk of periodontitis,dental caries,and external root resorption of adjacent second molars.Third molars are associated with complex surgical procedures,and treatment decisions and clinical management of third molars in this context remain controversial.This expert consensus was generated by oral surgeons and related specialists,who synthesized the current evidence-based literature and contemporary clinical practices.This consensus addresses critical considerations:the developmental trajectory and impaction characteristics of third molars,clinical and radiographic examinations of third molars,classification of impacted third molars,adverse effects of impacted third molars on oral health,indications for extraction,preoperative preparation for impacted third molar removal,anesthetic choices for impacted third molar surgery,recommended surgical protocol for impacted third molar removal,application of implant materials in alveolar sockets,management of common severe complications in impacted third molar extraction,and functional utilization of impacted third molars.Based on a comprehensive expert deliberation,this consensus provides evidence-based clinical guidance and standardized protocols for dental practitioners in the context of third molar management and therapeutic decision-making.
基金the Natural Science Foundation of China(Grant No.52471093)the Guangdong Basic and Applied Basic Research Foundation(Grant No.2024A1515012378)the State Key Laboratory of Solidification Processing Program of China(Grant No.2025-QZ-03)。
摘要Piston pumps are extensively employed in the industrial and aerospace sectors,particularly in applications that demand high-pressure operation and precise flow regulation.However,the inherent structural complexity of these components,coupled with their frequent exposure to adverse operating conditions,leads to various forms of surface degradation in friction pair elements.To address these challenges,researchers have pursued the development of advanced coating technologies aimed at enhancing surface hardness,reducing friction coefficients,and improving wear resistance.These coatings typically include metallic coatings,ceramic coatings,and diamond-like carbon(DLC)coatings,along with more cutting-edge yet highly promising high-entropy alloy(HEA)coatings.As a novel class of materials,HEA coatings hold considerable potential to overcome the inherent limitations of conventional coating systems.This review provides a comprehensive overview of recent advances in piston pump coating technologies,with particular emphasis on deposition methodologies,microstructural characteristics,and tribological performance.By establishing microstructure-property relationships within these coating systems,this study proposes future research directions for optimizing surface engineering approaches in hydraulic pump applications.
基金the National Natural Science Foundation of China(No.52175188)the Key Research and De-velopment Program of Shaanxi Province(No.2023-YBGY-434)+2 种基金the Open Fund of Liaoning Provincial Key Laboratory of Aero-engine Materials Tribology(No.LKLAMTF202301)the Guangdong Basic and Applied Basic Research Foundation(No.2024A1515012378)the Science and Technology on Reactor System Design Tech-nology Laboratory and the Fundamental Research Funds for the Central Universities.
摘要Ensuring the long-term and stable operation of mechanical equipment has been a research emphasis with the development of aerospace and polar exploration,which necessitates the prepared materials with high mechanical strength as well as excellent wear resistance[1].The traditional lubricant is widely acknowledged to be susceptible to evaporation or decomposition under extreme conditions,necessitating the deposition of a protective thin film on critical mechanical parts’surfaces to enhance their mechanical and tribological properties[2,3].
基金supported by the Natural Science Foundation of China(Nos.52175188 and 52274367)the Key Research and Development Program of Shaanxi Province(No.2023-YBGY-434)+2 种基金he Open Fund of Liaoning Provincial Key Laboratory of Aero-engine Materials Tribology(No.LKLAMTF202301)Guangdong Basic and Applied Basic Research Foundation(No.2024A1515012378)the Science and Technology on Reactor System Design Technology Laboratory.
摘要CoCrNi medium-entropy alloy has demonstrated remarkable mechanical properties,suggesting its potential as a structural material.Nevertheless,the challenge lies in achieving an elusive combination of high hardness and inherent self-lubrication on the worn surface,which is crucial for attaining exceptional tribological performance in medium-entropy alloy(MEA).This study reports the preparation of a novel CoCrNi-based self-lubricating composite by powder metallurgy,which is reinforced simultaneously with Ag solid lubricating phase and SiC ceramic particles.During the sintering process,SiC decomposes to form high hardness in situ Cr23C6,enabling the composite to achieve high load-bearing capacity.During the sliding process,thick and dense Ag self-lubricating film is successfully achieved due to the mechanical and thermal effects.The protective tribo-layer effectively mitigates surface stress concentration induced by wear,thereby inhibiting surface coarsening and substantially enhancing the tribological performance.The results showed that compared with CoCrNi MEA,the wear rate and friction coefficient of CoCrNi/SiC/Ag composite are reduced by 88.1%and 32.8%,respectively,showing superior tribological properties over most MEA-based self-lubrication composites.This study further elucidates the wear mechanism of CoCrNi/SiC/Ag composite,providing a new strategy for developing self-lubricating materials with excellent comprehensive performance,which overcomes the inherent trade-off between wear resistance and lubrication.
基金financially supported by the National Natural Science Foundation of China(Nos.82203680 and 52273278)the Natural Scientific Foundation of Liaoning Province(No.2021-MS-176)+1 种基金Shenyang Bureau of Science and Technology(No.RC230527)the Central Guidance Funding for Local Scientific and Techno-logical Development in Liaoning(No.2023JH6/100100029).
摘要Guided bone regeneration in the alveolar bone relies on the colonization and differentiation of immune cells within the defect area.The absence of osteoinductive and osteoimmune properties of currently available scaffolds hinders to achieve optimal repair outcomes in clinical settings.Thus,we aimed to enhance the bone repair ability of polycaprolactone(PCL)scaffolds by incorporating osteoinductive amorphous calcium phosphate(ACP)with immune-regulating zinc ions(ACP(Zn),ACZP),to create a favorable immunomodulatory microenvironment.After one day of co-culture with PCL-ACZP,the spreading area of macrophage cells was significantly higher than that from the original PCL scaffold.Additionally,over 32.1%of macrophages exhibited M2 polarization within three days of co-culture.The PCLACZP/macrophage-conditioned medium significantly boosted osteogenic gene expression in MC3T3-E1 cells.After eight weeks of implantation in a rat femoral condyle defect,the BV/TV from the PCL-ACZP group reached 32.9%,1.4 times of that from the PCL group.Furthermore,the PCL-ACZP-GelMA biphasic module as prepared successfully achieved complete regeneration of three-walled alveolar bone defects in rabbits,resulting in arch-shaped alveolar bone repair and providing greater convenience in the clinical settings.This study showcased the effectiveness of PCL-ACZP-GelMA biphasic module as bioactive scaffolds in the morphological restoration of alveolar bone.
基金supported by the Australian Research Council(LP220100036)the National Key Research and Development Program(2022YFB2502104 and 2022YFA1602700)+3 种基金the Key Research and Development Program of Jiangsu Provincial Department of Science and Technology of China(BE2022332)the Jiangsu Carbon Peak Carbon Neutralization Science and Technology Innovation Special Fund(BE2022605)the Australian Research Council for his Discovery Early Career Researcher Award fellowship(DE230101105)the China Scholarship Council(CSC,grant no.202306190185)for funding a scholarship。
摘要Zwitterionic materials with covalently tethered cations and anions have great potential as electrolyte additives for aqueous Znion batteries(AZIBs)owing to their appealing intrinsic characteristics and merits.However,the impact of cationic and anionic moieties within zwitterions on enhancing the performance of AZIBs remains poorly understood.Herein,three zwitterions,namely carboxybetaine methacrylate(CBMA),sulfobetaine methacrylate(SBMA),and 2-methacryloyloxyethyl phosphorylcholine(MPC),were selected as additives to investigate their different action mechanisms in AZIBs.All three zwitterions have the same quaternary ammonium as the positively charged group,but having different negatively charged segments,i.e.,carboxylate,sulfonate,and phosphate for CBMA,SBMA,and MPC,respectively.By systematical electrochemical analysis,these zwitterions all contribute to enhanced cycling life of Zn anode,with MPC having the most pronounced effect,which can be attributed to the synergistic effect of positively quaternary ammonium group and unique negatively phosphate groups.As a result,the Zn//Zn cell with MPC as additive in ZnSO4electrolyte exhibits an ultralong lifespan over 5000 h.This work proposes new insights to the future development of multifunctional zwitterionic additives for remarkably stable AZIBs.
基金supported by the National Natural Science Foundation of China(Nos.U21A2052,52071143 and 52301237)Guangdong Basic and Applied Basic Research Foundation(Nos.2023A1515010431 and 2022A1515011453)+1 种基金China Postdoctoral Science Foundation funded project(No.2022M720845)GDAS Project of Science and Technology Development(Nos.2022GDASZH-2022010104 and 2023GDASZH-2023010104)。
摘要Nanocrystalline Ce-based rare earth(RE)-Fe-B alloys exhibit relatively good hard magnetic properties and high performance-cost ratio,but their properties deteriorate seriously after hot deformation(HD).Here,we present a simplified one-step HD process for preparing anisotropic Ce-based Ce25.88La2.85Y4.56Fe65.73B0.98(wt%)magnets.The precursor of nanocrystalline powders is first compacted inside a copper tube,and then the powders with the tube are deformed together to achieve magnetic anisotropy.Compared with the conventional two-step HD magnet,i.e.,hot pressing followed by HD,one-step HD significantly increased the coercivity from 1.6 to 3.0 kOe,and the maximum magnetic energy product was improved from 3.7 to 4.8 MGOe.The microstructure characterization indicates that one-step HD can not only produce a more desirable microstructure,characterized by well-aligned platelet-shaped grains with reduced aspect ratio but also greatly inhibit the formation of coarse grain(CG)region.Both of them have been confirmed to be beneficial to enhancing coercivity by micromagnetic simulations.Our results thus demonstrate that the simplified one-step HD process offers a promising approach to developing high-performance anisotropic Ce-based magnets.
摘要Based on data from the investigation in Jiaozhou bay waters in 1979, the distribution, pollution source and seasonal variation of PHC in Jiaozhou Bay are analyzed. It is showed that in Jiaozhou bay PHC contents arrived the national Category Ⅱof the water quality standard during this year. In summer in the bay the pollution of PHC was heavy, while relatively light in spring. In the coastal waters in the east and the northeast of the bay, the PHC contents in spring surpassed the national Category Ⅱ, and surpassed the national Category Ⅲ. In the coastal waters, in the northeast of the bay, the change of the PHC contents formed the grads: the contents presented the falling trend from the big one to the small, which unveiled that the PHC souce in the bay mainly came from the discharge of the industrial waste water and living sewage.
基金financially supported by the National Key Research and Development Program of China(2022YFE0110300)the National Natural Science Foundation of China(52261145696 and 52473187)+1 种基金the“111”Projectthe Collaborative Innovation Center of Suzhou Nano Science and Technology,Soochow University。
摘要Organic-inorganic hybrid solar cells consisting of organic conjugated materials and inorganic quantum dots(QDs)have been of great interest during the past two decades.However,it is still challenging to select desired organic functional materials for fabricating hybrid films to maximize their photovoltaic performance.Herein,we report the synthesis of three narrow bandgap non-fullerene conjugated polymers and further demonstrate the importance and impact of polymer crystallinity in tuning the organic-inorganic hybrid interface towards improved photovoltaic performance.In specific,we develop an organic-inorganic hybrid active layer using a newly synthesized polymer with relatively weaker crystallinity and FAPbI3QDs,enabling complementary absorption and favorable interface/morphology for efficient charge separation and transport.The champion PCDOT-T/FAPbI3QD hybrid device achieves a record-high efficiency of 13.11%based on the one-step coating organic/QD hybrid bulk heterojunction blend,which is significantly improved relative to the semi-crystalline polymer PYIT-based hybrid device(11.23%)and pristine QD(10.51%).We believe these findings would provide new insight into the organic/QD interface to construct desired hybrid films for high-performing optoelectronic applications.
基金financially supported by the Key-Area Research and Development Program of Guangdong Province(No.2024B0101070002)the National Natural Science Foundation of China(Nos.U21A2052,52171175,and 52301237)+2 种基金the Basic and Applied Basic Research Foundation of Guangdong Province(No.2023A1515010431)the GDAS Project of Science and Technology Development(No.2022GDASZH-2022010104)the Young Talent Project of GDAS(No.2024GDASQNRC-0301)
摘要Enhancing the hard magnetic properties of Ce-Fe-B-based magnets remains a significant challenge due to the REFe2(RE=rare earth) phase precipitation.Here,Y substitution for Ce and Cu doping is employed to suppress REFe2 formation and optimize the intrinsic properties of RE2Fe14B phase.Partial substitution of Ce by Y significantly improves the magnetic properties and thermal stability of(Ce1-xYx)17Fe78B6(x=0-0.8,at%) alloys.First-principles calculations reveal that Y substitution destabilizes the REFe2 phase,thus inhibiting its formation.Notably,at substitution levels exceeding x> 0.4,the residual REFe2 phase undergoes a magnetic transition from paramagnetic to ferromagnetic behavior.Subsequent Cu doping in(Ce0.5Y0.5)17Fe77.6Cu0.4B6 alloys further destabilizes the REFe2 phase and transforms aggregated bulk phases into intergranular structures.This microstructural modification facilitates magnetic decoupling,yielding enhanced magnetic properties with coercivity of 435 kA m-1,remanence of 0.67 T and maximum energy product of 65.2 kJ m-3.Micromagnetic simulations confirm the positive roles of tailoring the distribution and magnetic behavior of the REFe2 phase in enhancing coercivity.Finally,the nanocrystalline(Ce0.5Y0.5)17Fe77.6-Cu0.4B6 powders synthesized via industrial overquenching/annealing demonstrate a high performance/cost ratio,highlighting their significant potential for cost-effective permanent magnet applications.
基金supported by grants from the Noncommunicable Chronic Diseases-National Science and Technology Major Project (Grant No. 2023ZD0501700)the National Natural Science Foundation of China (Grant No. 82373349)the MOE Changjiang Distinguished Professor Supporting Project (Grant No. KY0120240205)。
摘要Non-small cell lung cancer (NSCLC), as the leading cause of cancer-related deaths, poses a serious health issue worldwide1,according to the Global Cancer Statistics 2022. Approximately 30% of NSCLC patients are diagnosed at an advanced or metastatic stage with a 5-year overall survival (OS) rate ranging from 7%-18%2. Unlike localized NSCLC, which can be treated with curative intent, patients with metastatic NSCLC typically undergo systemic treatment to delay progression and prolong survival.
基金supported by the Beijing Natural Science Foundation(7244491)Beijing TCM Science and Technology Development Fund Project(BJZYON-2023-05)+2 种基金Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ15-YQ-048,ZZ-YQ2023006)Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-D-202409)Science and Technology Innovation Project of the Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences(CIZJS2025023).
摘要Depression is a prevalent neuropsychiatric disorder characterized by persistent sadness,anhedonia,guilt,fatigue,and impaired concentration.Although pharmacotherapy and psychotherapy can be effective,their utility is limited by adverse effects and significant inter-individual variability.Non-pharmacological therapies from traditional medicine have emerged as promising adjuncts owing to their favorable safety profiles,minimal side effects,and high patient compliance.These therapies,including acupoint stimulation,meditation,and yoga,produce antidepressant effects by reducing neuroinflammation,modulating neurotransmitter release,enhancing neuroplasticity,and regulating the gut-brain axis.This review summarizes clinical applications and mechanistic insights of traditional medicine’s non-pharmacological therapies for depression,providing a scientific rationale for their integration into comprehensive management.
基金supported by the National Natural Science Foundation of China(Nos.41902068,42272106)Young Scholars Development Fund of Southwest Petroleum University(No.201499010083)China Geological Survey Project(Nos.DD20230338,DD20242494)。
摘要The Jianglang Dome has integral tectonostratigraphic units and contains a suite of high-grade stratiform Cu deposits.However,the formation mechanism of this dome and genetic model of Cu mineralization remain a matter of debate.The resolution of these problems hinges on the presence of magmatic intrusions in the core.Here,we report bulk geochemical and zircon U-Pb data of a newly discovered syenite intrusion as well as chalcopyrite Re-Os dating results.We aim to explore genesis of the Jianglang Dome,genetic model of the stratiform Cu deposits,and rare metal mineralization potential of the syenite intrusion.The dated syenite sample yields an emplacement age of 207.1±2.0 Ma,which matches post-collisional extension in the Songpan-Ganze Orogen.The syenite rocks have average high(Zr+Nb+Ce+Y)concentrations of 512 ppm,10000.Ga/Al ratios of 3.97,and crystallization temperatures of 827°C,together with low Mg#values of 1.73;they fi t the A-type granitoid defi nition and a crustal origin.Chalcopyrite separates yield a Re-Os isochron age of 207.1±5.3 Ma,which markedly postdates the formation age of their orehosting rocks(the Liwu Group,ca.553 Ma).Our new age determination,together with previous chalcopyrite Re–Os isochron age of ca.151.1 Ma and sulfi de sulfur isotope(δ34SV-CDT=8.7‰–5.6‰)and tourmaline boron isotope(δ11B=−15.47‰to−5.91‰)data,confi rms multistage epigenetic Cu mineralization related to magmatic-hydrothermal fl uids.Compared with regional ca.209–207 Ma fertile granitoids,the studied syenite intrusion shows unevolved and barren affi nities and negligible rare metal mineralization potential.Combined with residual gravity low anomalies in the core of the Jianglang Dome,which suggest a large deepseated granitic batholith,we prefer thermal doming resulting from magma-induced uplift for the nature of this dome.
基金funded by the National Natural Science Foundation of China(82174093).
摘要Objective:To improve the efficacy of Astragalus membranaceus(Fisch.)Bunge(A.membranaceus,Huang Qi),and to further develop and utilize it,fermentation technology was applied to the stem and leaf of A.membranaceus to enhance its immune function.Methods:In this study,we fermented A.membranaceus stem and leaf(ASL)with probiotics and inves-tigated its immune function.Firstly,we screened suitable strains for ASL fermentation and optimized the fermentation process.Secondly,we determined the antioxidant capacity of fermented ASL and its effect on inflammation in mouse monocyte-macrophage cell.Finally,the immunocompromised mice were treated with fermented ASL to investigate the changes in their immune ability.Results:Among the 10 selected probiotics,Lactobacillus plantarum was the most suitable strain for ASL fermentation.After optimization of the fermentation process,the content of saponins in fermented ASL was significantly increased.The fermented ASL exhibited strong anti-inflammatory and antioxidant activities in vitro.The in vivo immune efficacy improved by promoting the development of the spleen and thymus,as well as raising the immunoglobulin M,tumor necrosis factor-α,and interleukin-1β levels of in the serum.Conclusion:This study contributes to developing the non-medicinal parts of A.membranaceus,expands its medicinal resources,highlights the potential of fermentation technology to enhance these parts,and provides a reference for further development.Based on this approach,we can promote using non-me-dicinal parts of herbal medicines,minimize drug waste,and offer a reference for developing non-me-dicinal components in Chinese herbal medicines.
基金Supported by the Graduate Research and Practice Innovation Program of Jiangsu Province,No.KYCX233374.
摘要BACKGROUND Gastrointestinal surgical acute abdomen conditions.These conditions not only cause significant suffering to patients but also increase psychological stress for both patients and their families.AIM To investigate communication characteristics in gastrointestinal surgical acute abdomen cases(such as appendicitis and pancreatitis)and explore optimization pathways.METHODS Eighty-two patients with gastrointestinal surgical acute abdomen(including appendicitis and pancreatitis)admitted to the hospital between November 2022 and June 2024 were selected.Physician-patient communication characteristics were analyzed.Patients were randomly divided into two groups(41 each)using a random draw method.The control group received conventional physician-patient communication.The observation group received an optimized communication model based on the conventional method.The two groups were compared for treatment efficacy and outcomes,psychological status,coping strategies,sleep quality,and compliance.RESULTS Significant differences were observed between the two groups in terms of time to ambulation and duration of hospital stay(P0.05).After the intervention,the psychological status scale scores in both groups decreased significantly(P<0.05),with significant differences between the groups(P<0.05).Following the intervention,the facing subscale scores of the medical coping questionnaire increased,while the avoidance and submission subscale scores decreased(P<0.05),with significant differences between the groups(P<0.05).The observation group had lower scores on the sleep quality scale(P<0.05).The compliance rate was higher in the observation group(97.56%vs 80.49%,P<0.05).CONCLUSION Physician-patient communication presented contradictions between professionalism and laymen’s expression and rigid communication methods.Optimizing communication models can improve sleep quality,coping strategies,patient compliance,and treatment outcomes and reduce negative emotions.
摘要Rural education in China faces significant challenges,including limited resources,declining student enrollment,and frequent school closures.This paper examines the educational leadership and management strategies employed by Simin Primary School,a century-old rural institution in Zhuji City,which has successfully revitalized its community and attracted students through the innovative practice of nature education.By leveraging local cultural and environmental resources,the school has established a sustainable model for small rural schools.
基金the Natural Science Foundation of Anhui Province,No.9741006Natural Science Foundation of Anhui Educational Commission,No.JL-97-077.
摘要INTRODUCTION Hepatitis B is one of the common infectious diseases,which severely impairs the health of the people in our country and has close relationship
摘要Objective: To evaluate the efficacy and safety of nedaplatin/gemcitabine (NG) and carboplatin/gemcitabine (CG) in the management of untreated advanced non-small cell lung cancer (NSCLC). Methods: Sixty-two patients with previously untreated advanced NSCLC were recruited between June 2006 and November 2007. Subjects were randomly assigned to the NG arm (n=30) and the CG arm (n=32). Only patients (24 and 25 in the NG and CG arms, respectively) who completed 〉2 chemotherapy cycles were included in the data analysis. The primary outcome measure was the objective response rate (ORR). The secondary outcome measures included progression-free survival (PFS), overall survival (OS) and adverse events. Results: There were no statistically significant differences in the efficacy measures (ORR, P=0.305; median PFS, P=0.298, median OS, P=0.961) or in the major adverse events (grade 3/4 neutropenia, P=0.666; grade 3/4 anemia, P=0.263; grade 3/4 thrombocytopenia, P=0.222) between the two treatment arms. However, there was a trend towards higher ORR (37.5% vs. 24.0%), longer PFS (6.0 vs. 5.0 months), and less adverse events in the NG arm. Conclusion: NG regimen seems to be superior over CG regimen for advance NSCLS, but further investigation is needed to validate this superiority.