期刊文献+
任意字段
题名或关键词
题名
关键词
摘要
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息
共找到16篇文章
< 1 >
每页显示 20 50 100
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
显示方式：
Benzyl sulfide, sulfoxide and sulfinate metabolites from Gastrodia elata and their synthesis, derivatization and anti-inflammatory activity 认领 引用
1
作者 Chengbo Xu Lei Wang +7 位作者 Xue Zhou Shuai Shao Chengjuan Chen Xiaoqiang Lei Tiantai Zhang Jiachen Zi Jiangong Shi Qinglan Guo 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2026年第3期365-372,共8页
Five novel sulfur-containing benzyl metabolites, designated as gastrabenzylsulfoxides A and B(1 and 2), gastrabenzylsulfinate A(3) and gastrabenzylsulfides A and B(4 and 5), along with four known compounds(6-9), were ... Five novel sulfur-containing benzyl metabolites, designated as gastrabenzylsulfoxides A and B(1 and 2), gastrabenzylsulfinate A(3) and gastrabenzylsulfides A and B(4 and 5), along with four known compounds(6-9), were isolated from the aqueous extracts of Gastrodia elata.Compounds 1 and 4 are 4-hydroxy-3-(4′-hydroxybenzyl)benzyl-substituted sulfoxide and sulfide, respectively, which are unprecedented in natural products. Compound 3 represents a rare sulfinate. Several isolates and their sulfone and disulfide analogs(10-13) were synthesized to evaluate their anti-inflammatory activity. Notably, the synthesized sulfone 10 demonstrated significant alleviation of symptoms in multiple in vivo inflammatory models. 展开更多
关键词 Gastrodia elata Sulfur-bearing benzyl metabolites Synthesis Anti-inflammatory activity
暂未订购 下载PDF
Insight into Medicinal Chemistry Behind Traditional Chinese Medicines: p-Hydroxybenzyl Alcohol-Derived Dimers and Trimers from Gastrodia elata 认领 引用 被引量：15
2
作者 Yanan Wang Min Zhang +7 位作者 Xue Zhou Chengbo Xu Chenggen Zhu Yuhe Yuan Naihong Chen Yongchun Yang Qinglan Guo Jiangong Shi 《Natural Products and Bioprospecting》 CSCD 2021年第1期31-50,共20页
From an aqueous extract of“tian ma”(the steamed and dried rhizomes of Gastrodia elata),ten new compounds gastrodiben-zins A−D(1−4)and gastrotribenzins A−F(5−10),along with known analogues(11−20),having structure fea... From an aqueous extract of“tian ma”(the steamed and dried rhizomes of Gastrodia elata),ten new compounds gastrodiben-zins A−D(1−4)and gastrotribenzins A−F(5−10),along with known analogues(11−20),having structure features coupling between two and three p-hydroxybenzyl-derived units via carbon-and/or ether-bonds,were isolated and characterized by spectroscopic data analysis.Meanwhile,the new compounds 5a,6a,8a,22,and 23,as well as the known derivatives 13a,14a,15,17−21,24,25,and p-hydroxybenzyl aldehyde were isolated and identified from a refluxed aqueous solution of p-hydroxybenzyl alcohol.Methylation of 5a and 6a in methanol and ethylation of 6a,8a,13a,and 14a in ethanol produced 5 and 6 and 7,8,13,and 14,respectively.using ultra-performance liquid chromatography high-resolution electrospray ioniza-tion mass spectrometry(UPLC-HRESIMS)analysis of the refluxed solutions of p-hydroxybenzyl alcohol and the refluxed extracts of the fresh G.elata rhizome and“tian ma”extracts indicated consistent production and variation of the dimeric and trimeric derivatives of p-hydroxybenzyl alcohol upon extracting solvents and refluxing time.In various assays,the dimeric and trimeric derivatives showed more potent activities than p-hydroxybenzyl alcohol itself and gastrodin,which are the main known active constituents of“tian ma”.These results revealed for the first time that the more effective dimers and trimers can be produced through condensation of the co-occurring p-hydroxybenzyl alcohol during processing and decocting of the G.elata rhizomes,demonstrating insights into medicinal chemistry behind application protocols of traditional Chinese medicines. 展开更多
关键词 Orchidaceae Gastrodia elata p-Hydroxybenzyl alcohol dimer p-Hydroxybenzyl alcohol trimer Gastrodibenzins Gastrotribenzins Medicinal chemistry behind Chinese medicines
暂未订购 下载PDF
Isatindolignanoside A, a glucosidic indole-lignan conjugate from an aqueous extract of the Isatis indigotica roots 认领 引用 被引量：11
3
作者 Lingjie Meng Qinglan Guo +3 位作者 Minghua Chen JiANDong Jiang Yuhuan Li Jiangong Shi 《Chinese Chemical Letters》 SCIE CAS CSCD 2018年第8期1257-1260,共4页
A glucosidic indole-lignan conjugate with a novel carbon skeleton, named isatindolignanoside A（1）, was isolated from an aqueous extract of the Isatis indigotica roots ＂ban lan gen＂. Its structure was elucidated by... A glucosidic indole-lignan conjugate with a novel carbon skeleton, named isatindolignanoside A（1）, was isolated from an aqueous extract of the Isatis indigotica roots ＂ban lan gen＂. Its structure was elucidated by comprehensive analysis of spectroscopic data, including J-and NOESY correlation-based configurational analysis, circular dichroism（CD） data, enzyme hydrolysis, and theoretical ECD calculation. In a preliminary assay, compound 1 showed antiviral activity against Coxsackie virus B3. This compound is the first example of natural product having a structural feature of conjugation between indole and lignan units, and its biosynthetic pathway is postulated. 展开更多
关键词 Isatis indigotica Cruciferae Ban lan gen Indole-lignan conjugate Isatindolignanoside A Antiviral activity
暂未订购 下载PDF
Phthalide-derived oxaspiroangelioic acids A–C with an unprecedented carbon skeleton from an aqueous extract of the Angelica sinensis root head 认领 引用 被引量：11
4
作者 Youzhe Chen Chengbo Xu +3 位作者 Weiping Wang Xiaoliang Wang Qinglan Guo Jiangong Shi 《Chinese Chemical Letters》 SCIE CAS CSCD 2021年第10期3257-3260,共4页
Three phthalide-derived analogues,oxaspiroangelioic acids A–C(1–3),were isolated as minor components of an aqueous extract of the Angelica sinensis root heads(guitou).Oxaspiroangelioic acids A and B were racemates s... Three phthalide-derived analogues,oxaspiroangelioic acids A–C(1–3),were isolated as minor components of an aqueous extract of the Angelica sinensis root heads(guitou).Oxaspiroangelioic acids A and B were racemates separated into enantiomers by chiral HPLC.Their structures including absolute configurations were determined by spectroscopic data analysis,single crystal X-ray diffraction,exciton chirality method [7TD$IF]and electronic circular dichroism(ECD) calculation.These compounds share an undescribed carbon skeleton,for which biosynthetic pathways are proposed.Compound 1 and its enantiomers showed almost identical activity inhibiting Tandem of P domains in a weak inwardly rectifying K+channel 1(TREK-1). 展开更多
关键词 Umbelliferae Angelica sinensis Phthalide-derived analogues Oxaspiroangelioic acids A–C
暂未订购 下载PDF
(+)-/(-)-Angelignanine,a pair of neolignan enantiomers with an unprecedented carbon skeleton from an aqueous extract of the Angelica sinensis root head 认领 引用 被引量：8
5
作者 Youzhe Chen Qinglan Guo +3 位作者 Chengbo Xu Chenggen Zhu Jianjun Zhang Jiangong Shi 《Chinese Chemical Letters》 SCIE CAS CSCD 2021年第5期1657-1659,共3页
A pair of neolig nan enan tiomers with an unprecedented carb on skelet on,(+)-/(-)-angeligna nine[(+)-/(-)-1].was isolated as minor components of an aqueous extract of the Angelica sinensis root heads(guitou).Their st... A pair of neolig nan enan tiomers with an unprecedented carb on skelet on,(+)-/(-)-angeligna nine[(+)-/(-)-1].was isolated as minor components of an aqueous extract of the Angelica sinensis root heads(guitou).Their structures were determined by spectroscopic data analysis and the absolute configurations were assigned by the circular dichroism(CD)exciton chirality method as well as electronic CD quantum calculations.The enantiomers represent the first 2,7/-cyclo-8,9z-neolignans,of which biosynthetic pathways originating from precursors ferulic acid and coniferyl alcohol is proposed.In an in vivo test,both the enantiomers showed significant hypnotic effects at a dose of 10 mg/kg(i.g.). 展开更多
关键词 Umbelliferae Angelica sinensis Neolignan 2,7/-Cyclo-8,9/-neolignan (+)-/(-)-Angelignanine
暂未订购 下载PDF
Aconapelsulfonines A and B,seco C20-diterpenoid alkaloids deriving via Criegee rearrangements of napelline skeleton from Aconitum carmichaelii 认领 引用 被引量：8
6
作者 Hui Liu Yuzhuo Wu +4 位作者 Qinglan Guo Shuai Shao Chengbo Xu Tiantai Zhang Jiangong Shi 《Chinese Chemical Letters》 SCIE CAS CSCD 2021年第1期33-36,共4页
Two sulfo nated seco C20-diterpenoid alkaloids,aconapelsulfonines A(1) and B(2),were isolated from an aqueous extract of the raw material of "Fu Zi"(the Aconitum carmichaelii lateral roots),of which the s... Two sulfo nated seco C20-diterpenoid alkaloids,aconapelsulfonines A(1) and B(2),were isolated from an aqueous extract of the raw material of "Fu Zi"(the Aconitum carmichaelii lateral roots),of which the structures were elucidated by various spectroscopic data,combined with X-ray crystallogra phic analysis.The unprecedented skeletons are biogenetically proposed to be derived via Criegee rearrangements of the napelline-type architecture.The two compounds exhibited dose-depended analgesic activities on an acetic acid-induced mice writhing test. 展开更多
关键词 Ranunculaceae Aconitum carmichaelii C20-Diterpenoid alkaloid Aconapelsulfonine Analgesic activity
暂未订购 下载PDF
Two unique C21-diterpenoid alkaloids from Aconitum carmichaelii 认领 引用 被引量：8
7
作者 Jingfang Zhang Xiaoqiang Lei +4 位作者 Yazi Wei Hui Liu Qinglan Guo Tiantai Zhang Jiangong Shi 《Chinese Chemical Letters》 SCIE CAS CSCD 2022年第12期5047-5050,共4页
Two sulfonated diterpenoid alkaloids possessing different but related novel carbon skeletons,named aconidenusulfonine A(1)and 12,16-secoaconidenusulfonine A(2),respectively,were isolated as minor components from an aq... Two sulfonated diterpenoid alkaloids possessing different but related novel carbon skeletons,named aconidenusulfonine A(1)and 12,16-secoaconidenusulfonine A(2),respectively,were isolated as minor components from an aqueous extract of the lateral roots of Aconitum carmichaelii("Fu Zi").The structures of 1 and 2,representing the first two C21-diterpenoid alkaloids from nature,were determined by analysis of various spectroscopic data and chemical transformation,of which 1 was further proved by single-crystal X-ray diffraction.Especially,1 exhibited dose-depended analgesic activity consistent with the clinical function of Fu Zi. 展开更多
关键词 Ranunculaceae Aconitum carmichaelii C21-diterpenoid alkaloid Aconidenusulfonine Analgesic activity
暂未订购 下载PDF
Sesquiterpene glycosides from the roots of Codonopsis pilosula 认领 引用 被引量：27
8
作者 Yueping Jiang Yufeng Liu +3 位作者 Qinglan Guo Chengbo Xu Chenggen Zhu Jiangong Shi 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2016年第1期46-54,共9页
Three new sesquiterpene glycosides,named codonopsesquilosides A C(1 3),were isolated from an aqueous extract of the dried roots of Codonopsis pilosula.Their structures including absolute configurations were determined... Three new sesquiterpene glycosides,named codonopsesquilosides A C(1 3),were isolated from an aqueous extract of the dried roots of Codonopsis pilosula.Their structures including absolute configurations were determined by spectroscopic and chemical methods.These glycosides are categorized as C15 carotenoid(1),gymnomitrane(2),and eudesmane(3)types of sesquiterpenoids,respectively.Compound 1 is the first diglycoside of C15 carotenoids to be reported.Compound 2 represents the second reported example of gymnomitrane-type sesquiterpenoids from higher plants.The absolute configurations were supported by comparison of the experimental circular dichroism(CD)spectra with the calculated electronic CD(ECD)spectra of 13,their aglycones,and model compounds based on quantummechanical time-dependent density functional theory.The influences of the glycosyls on the calculated ECD spectra of the glycosidic sesquiterpenoids,as well as some nomenclature and descriptive problems with gymnomitrane-type sesquiterpenoids are discussed. 展开更多
关键词 Codonopsis pilosula Campanulaceae Sesquiterpene glycoside Codonopsesquilosides A-C C15 carotenoid Gymnomitrane Eudesmane
暂未订购 下载PDF
Acetylenes and fatty acids from Codonopsis pilosula 认领 引用 被引量：25
9
作者 Yueping Jiang Yufeng Liu +6 位作者 Qinglan Guo Zhibo Jiang Chengbo Xu Chenggen Zhu Yongchun Yang Sheng Lin Jiangong Shi 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2015年第3期215-222,共8页
Four new acetylenes (1-4) and one new unsaturated to-hydroxy fatty acid (5), together with known analogues, were isolated from an aqueous extract of Codonopsis pilosula roots. Their structures were determined by spect... Four new acetylenes (1-4) and one new unsaturated to-hydroxy fatty acid (5), together with known analogues, were isolated from an aqueous extract of Codonopsis pilosula roots. Their structures were determined by spectroscopic and chemical methods. The new acetylenes are categorized as an unusual cyclotetradecatrienynone (1), tetradocenynetriol (2), and rare octenynoic acids (3 and 4), respectively, and 3 and 4 are possibly derived from oxidative metabolic degradation of 1 and/or 2. The absolute configuration of I. was assigned by comparison of the experimental circular dichroism (Cl)) spectrum with the calculated electronic circular dichroism (ECD) spectra of stereoisomers based on the quantum-mechanical time-dependent density functional theory, while the configuration of 2 was assigned by using modified Mosher's method based on the MPA determination rule of AoRs values for diols. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier By. 展开更多
关键词 codonopsis pilosala Campanulacea Cyclotetradecatrienynone Tetradecenynetriol Octenynoic acids Unsaturated omega-hydroxy fatty acid
暂未订购 下载PDF
4-Hydroxybenzyl-substituted amino acid derivatives from Gastrodia elata 认领 引用 被引量：26
10
作者 Qinglan Guo Yanan Wang +7 位作者 Sheng Lin Chenggen Zhu Minghua Chen Zhibo Jiang Chengbo Xu Dan Zhang Huailing Wei Jiangong Shi 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2015年第4期350-357,共8页
Seven new 4-hydroxyben l-substituted amino acid derivatives (1-7), together with 11 known compounds, were isolated from an aqueous extract of the rhizomes of Go,arodia data Blume. Their structures were determined by s... Seven new 4-hydroxyben l-substituted amino acid derivatives (1-7), together with 11 known compounds, were isolated from an aqueous extract of the rhizomes of Go,arodia data Blume. Their structures were determined by spectroscopic and chemical methods. Compounds 1-3 are pyroglutamate derivatives containing 4-hydroxybenzyl units at the N atom and 4-7 are the first examples of natural products with the 4-hydroxybenzyl unit linked vici a thioether bond to 2-hydroxy-3mercaptopropanoic acid (4-6) and 2-hydroxy-4-mercaptobutanoic acid (7), which would be biogenetically derived from cysteine and homocysteine, respectively. The structures of 1 and 2 were verified hi synthesis, while the absolute configurations of 4, 5 and 7 were assigned using Mosher 's method based on the MPA determination rule of A5Rs values. The known compound 4-(hydroxymethy0-5-nifrobenzene1,2-diol (8) exhibited activity against Fe2 r--cysteine induced rat liver microsomal lipid peroxidation with 1050 values of 9.99 x 10 6 mon. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.'s/. This is an open access article under the CC BY-NC-ND license (http://gffzzeb6f7f563f66445dh5k6pu6fqc9p06wvn.ffgz.tsg.suse.edu.cn/licenses/by-nc-nd/4.0/). 展开更多
关键词 Gastrodia elata Blume Orchidaceae 4-Hydroxybenzyl substituted amino acid derivates Pyroglutamate derivatives Inhibitory activity
暂未订购 下载PDF
Sulfur-enriched alkaloids from the root of Isatis indigotica 认领 引用 被引量：11
11
作者 Qinglan Guo Chengbo Xu +6 位作者 Minghua Chen Sheng Lin Yuhuan Li Chenggen Zhu JiANDong Jiang Yongchun Yang Jiangong Shi 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2018年第6期933-943,共11页
Five new sulfur-enriched alkaloids isatithioetherins A–E(1–5), and two pairs of scalemic enantiomers(t)-and( à)-isatithiopyrin B(6 a and 6 b) and isoepigoitrin and isogoitrin(7 a and 7 b), along with the known ... Five new sulfur-enriched alkaloids isatithioetherins A–E(1–5), and two pairs of scalemic enantiomers(t)-and( à)-isatithiopyrin B(6 a and 6 b) and isoepigoitrin and isogoitrin(7 a and 7 b), along with the known scalemic enantiomers epigoitrin and goitrin(8 a and 8 b), were isolated and characterized from an aqueous extract of the Isatis indigotica roots. Their structures were determined by extensive spectroscopic data analysis, including 2 D NMR and theoretical calculations of electronic circular dichroism(ECD) spectra based on the quantum-mechanical time-dependent density functional theory(TDDFT). Compounds 1–5 represent a novel group of sulfur-enriched alkaloids, biogenetically originating from stereoselective assemblies of epigoitrin-derived units. Isolation and structure characterization of 6 a and 6 b support the postulated biosynthetic pathways for the diastereomers 9 a and 9 b via a rare thio-Diels–Alder reaction. Compounds 2 and 4 showed antiviral activity against the influenza virus A/Hanfang/359/95(H3 N2, IC500.60 and 1.92 μmol/L) and the herpes simplex virus 1(HSV-1, IC503.70 and 2.87 μmol/L), and 2 also inhibited Coxsackie virus B3(IC500.71 μmol/L).& 2018 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license(http://gffzzeb6f7f563f66445dh5k6pu6fqc9p06wvn.ffgz.tsg.suse.edu.cn/licenses/by-nc-nd/4.0/). 展开更多
关键词 Cruciferae Isatis indigotica Sulfur-containing alkaloids Isatithioetherins A–E Isatithiopyrins A and B Isoepigoitrin Isogoitrin Antiviral activity
暂未订购 下载PDF
C19-Diterpenoid alkaloid arabinosides from an aqueous extract of the lateral root of Aconitum carmichaelii and their analgesic activities 认领 引用 被引量：15
12
作者 Qinglan Guo Huan Xia +5 位作者 Xianhua Meng Gaona Shi Chengbo Xu Chenggen Zhu Tiantai Zhang Jiangong Shi 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2018年第3期409-419,共11页
Eight new C19-diterpenoid alkaloid arabinosides, named aconicarmichosides E–L(1–8), were isolated from an aqueous extract of the lateral roots of Aconitum carmichaelii(Fu Zi). Their structures were determined by ... Eight new C19-diterpenoid alkaloid arabinosides, named aconicarmichosides E–L(1–8), were isolated from an aqueous extract of the lateral roots of Aconitum carmichaelii(Fu Zi). Their structures were determined by spectroscopic and chemical methods including 2D NMR experiments and acid hydrolysis. Compounds 1–8, together with the previously reported four neoline 14-O-arabinosides from the same plant, represent the only examples of glycosidic diterpenoid alkaloids so far. At a dose of 1.0 mg/kg(i.p.), as compared with the black control, compounds 1, 2, and 4–6 exhibited analgesic effects with 465.6% inhibitions against acetic acid-induced writhing of mice. Structure–activity relationship was also discussed. 展开更多
关键词 Ranunculaceae Aconitum carmichaelii C19-diterpenoid alkaloid Arabinoside Aconicarmichosides E-L Analgesic effect Structure–activity relationship
暂未订购 下载PDF
Indole alkaloid sulfonic acids from an aqueous extract of Isatis indigotica roots and their antiviral activity 认领 引用 被引量：18
13
作者 Lingjie Meng Qinglan Guo +4 位作者 Yufeng Liu Minghua Chen Yuhuan Li Jiandong Jiang Jiangong Shi 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2017年第3期334-341,共8页
Six new indole alkaloid sulfonic acids(1–6), together with two analogues(7 and 8) that were previously reported as synthetic products, were isolated from an aqueous extract of the Isatis indigotica root. Their struct... Six new indole alkaloid sulfonic acids(1–6), together with two analogues(7 and 8) that were previously reported as synthetic products, were isolated from an aqueous extract of the Isatis indigotica root. Their structures including the absolute configurations were determined by spectroscopic data analysis, combined with enzyme hydrolysis and comparison of experimental circular dichroism and calculated electronic circular dichroism spectra. In the preliminary assay, compounds 2 and 4 showed antiviral activity against Coxsackie virus B3 and influenza virus A/Hanfang/359/95(H3N2), respectively. 展开更多
关键词 Cruciferae Isatis indigotica Indole alkaloid sulfonic acids Isatibis indosulfonic acids Isatindosulfonic acids Antiviral activity
暂未订购 下载PDF
8,4′-Oxyneolignane glucosides from an aqueous extract of“ban lan gen”(Isatis indigotica root)and their absolute configurations 认领 引用 被引量：16
14
作者 Lingjie Meng Qinglan Guo +1 位作者 Yufeng Liu Jiangong Shi 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2017年第6期638-646,共9页
Three pairs of glycosidic 8,4′-oxyneolignane diastereoisomers, named isatioxyneolignosides A-F(1–6), were isolated from an aqueous extract of Isatis indigotica roots. Their structures and absolute configurations wer... Three pairs of glycosidic 8,4′-oxyneolignane diastereoisomers, named isatioxyneolignosides A-F(1–6), were isolated from an aqueous extract of Isatis indigotica roots. Their structures and absolute configurations were elucidated by comprehensive spectroscopic data analysis and enzyme hydrolysis. The validity of ΔδC8-C7 values to distinguish threo and erythro aryl glycerol units and Cotton effects at 235±5 nm to determine absolute configurations at C-8 in 1–6 and their aglycones(1a–6a) are discussed. 展开更多
关键词 Cruciferae Isatis indigotica Isatioxyneolignosides A-F 8,4′-Oxyneolignane Threolerythro Isomers ΔδC8-C7 value Absolute configuration Cotton effect
暂未订购 下载PDF
Aromatic compounds from an aqueous extract of “ban lan gen” and their antiviral activities 认领 引用 被引量：12
15
作者 Yufeng Liu Minghua Chen +3 位作者 Qinglan Guo Yuhuan Li Jiandong Jiang Jiangong Shi 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2017年第2期179-184,共6页
A pair of new diphenyl glycerol ether enantiomers(-)-l and(+)-l and two new methyl benzamidobenzoates 2 and 3,named(-)-(R)-and(+)-(S)-isatindigotrioic acid[(-)-l and(+)-l]and isatindigoticamides A(2) and B(3),respecti... A pair of new diphenyl glycerol ether enantiomers(-)-l and(+)-l and two new methyl benzamidobenzoates 2 and 3,named(-)-(R)-and(+)-(S)-isatindigotrioic acid[(-)-l and(+)-l]and isatindigoticamides A(2) and B(3),respectively,were isolated from an aqueous decoction of the roots of Isatis indigotica(ban lan gen).Their structures were elucidated by spectroscopic data analysis including2 D NMR experiments.The absolute configurations of(-)-l and(+)-l were assigned based on the CD exciton chirality method.Compounds 2 and 3 exhibited antiviral activities against HSV-1 with IC50values of 4.87 and 25.87μmol/L,respectively.Compound 2 was also found active against Coxsackie virus B3 and LPS-induced NO production. 展开更多
关键词 Cruciferae Isatis indigotica Aromatic metabolite Antiviral activity
暂未订购 下载PDF
Indole alkaloid glycosides with a 1′-(phenyl)ethyl unit from Isatis indigotica leaves 认领 引用 被引量：4
16
作者 Qinglan Guo Dawei Li +5 位作者 Chengbo Xu Chenggen Zhu Ying Guo Haibo Yu Xiaoliang Wang Jiangong Shi 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2020年第5期895-902,共8页
Seven indole alkaloid glycosides containing a 1′-(4″-hydroxy-3″,5″-dimethoxyphenyl)ethyl unit(1-7)were isolated from an aqueous extract of Isatis indigotica leaves(da qing ye).Their structures were determined by s... Seven indole alkaloid glycosides containing a 1′-(4″-hydroxy-3″,5″-dimethoxyphenyl)ethyl unit(1-7)were isolated from an aqueous extract of Isatis indigotica leaves(da qing ye).Their structures were determined by spectroscopic data analysis combined with enzymatic hydrolysis as well as comparison of their experimental CD(circular dichroism)and calculated ECD(electrostatic circular dichroism)spectra.Based on analysis of[α]D20 and/or Cotton effect(CE)data of 1-7,two simple roles to assign location and/or configuration ofβ-glycopyranosyloxy and 1′-(phenyl)ethyl units in the indole alkaloid glycosides are proposed.Stereoselectivity in plausible biosynthetic pathways of 1-7 is discussed.Compounds 3 and 4 and their mixture in a 3:2 ratio showed activity against KCNQ2 in CHO cells.The mixture of 5 and 6(3:2)exhibited antiviral activity against influenza virus H1 N1 PR8 with IC5064.7μmol/L(ribavirin,IC5054.3μmol/L),however,the individual 5 or 6 was inactive.Preliminary structure-activity relationships were observed. 展开更多
关键词 Cruciferae Isatis indigotica Indole alkaloid glycoside Isatidifoliumosides Epiisatidifoliumosides KCNQ2 inhibition Anti-infuenza Anti-virus Activity
暂未订购 下载PDF
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
上一页 1 下一页 到第 页
在线咨询 使用帮助 返回顶部 意见反馈