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Preoperative ECMO Bridging in Pediatric Heart Transplantation:A Cohort Study on Graft Remodeling,Inflammatory Biomarkers and Survival 认领 引用
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作者 Hui Yi Hongjian Shi +11 位作者 Fuquan Kan Fan Han LeiWan Xiaoyang Hong Zhe Zhao Junjie Shao Gang Wang HuiWang Hua Yan Xiujuan Shi Ran Zhang Gengxu Zhou 《Congenital Heart Disease》 SCIE 2025年第4期519-530,共12页
Background:To investigate the impact of preoperative extracorporeal membrane oxygenation(ECMO)on clinical outcomes in pediatric heart transplantation(PHT).Methods:This retrospective cohort analysis was conducted on 19... Background:To investigate the impact of preoperative extracorporeal membrane oxygenation(ECMO)on clinical outcomes in pediatric heart transplantation(PHT).Methods:This retrospective cohort analysis was conducted on 19 pediatric heart transplant recipients,divided into two groups:ECMO and non-ECMO,based on whether preoperative ECMO was utilized.We evaluated the patients'surgical conditions,postoperative complications,and survival rates.Additionally,the analysis focused on the differences and correlations in clinical characteristics,inflammatory markers,and long-term survival outcomes.Results:There was no statistically significant difference in perioperative survival rates between the ECMO group(85.7%)and the non-ECMO group(83.3%).However,the ECMO group exhibited significantly higher levels of inflammatory markers,including Interleukin-6(IL-6),Interleukin-8(IL-8),Interleukin-6(IL-10),Tumor Necrosis Factor-a(TNF-α),and C-reactive protein(CRP),compared to the non-ECMO group(p<0.05).Notably,IL-6,IL-8,and CRP levels in the ECMO group were found to normalize to the levels of the non-ECMO group 24 h after the operation.The cohort demonstrated a mean donor-recipient weight ratio of 1.38±0.39,with successful cardiac remodeling observed in recipients of oversized grafts,with the highest Donor-RecipientWeight Ratio(DRWR)reaching 3.0.Conclusions:The donor-recipient size mismatch plays a significant role in influencing the success rate of PHT.Despite the inflammatory response and perioperative complications,ECMO proves to be an effective bridging strategy,ultimately enhancing overall outcomes in PHT. 展开更多
关键词 Pediatric heart transplantation donor-recipient weight ratio extracorporeal membrane oxygenation cytokine
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Quantitative evaluation of coal fracability based on 3D CT reconstruction and fractal characteristics 认领 引用 被引量：1
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作者 Fanhui Zeng Weixin Yang +3 位作者 Jianchun Guo Ran Zhang Yu Zhang Zhangxing Chen 《Natural Gas Industry B》 2026年第1期60-76,共17页
Fracability is a critical indicator for evaluating the exploration and development potential of coalbed methane reservoirs and assessing the effectiveness of hydraulic fracturing stimulation operations.Its core functi... Fracability is a critical indicator for evaluating the exploration and development potential of coalbed methane reservoirs and assessing the effectiveness of hydraulic fracturing stimulation operations.Its core function is to characterize the complexity of the induced fracture network and the resulting effective stimulated volume.In this study,we quantified fracture area and geometric complexity using true triaxial fracturing experiments and computed tomography three-dimensional(3D)reconstruction technology,combined with the box-counting method to calculate the 3D fractal dimension of the fracture surfaces.The results revealed that the total fracture surface area per unit volume of the stimulated reservoir effectively characterized reservoir fracability;specifically,both a larger total fracture surface area and a higher fractal dimension corresponded to better reservoir fracability.Fracture complexity was enhanced by a decrease in the horizontal principal stress difference or an increase in the injection rate.Under optimal conditions of a 3 MPa stress difference and an injection rate of 60 mL/min,fracability improved by 27.6%.Furthermore,liquid carbon dioxide(CO2)improved fracability by 50.7%compared to using water as the fracturing fluid,a result attributed to its low viscosity and strong diffusion capacity,which activated a greater number of natural fractures.A fracability evaluation model integrating brittleness,fracture toughness,and dimensionless net pressure was developed using regression analysis,which demonstrated high reliability with a strong determination coefficient(R2)of 0.9019.This study clarifies the logical relationships among fracture area,complexity,and fractal dimension,providing a novel method for evaluating the fracability of coal reservoirs. 展开更多
关键词 Coal Fracability evaluation 3D reconstruction Fractal dimension Fracture area
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Laser-implantation strategy regulating dynamic evolution for ultra-stable CO2hydrogenation 认领 引用
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作者 Rongxia Zhao Shilin Fan +10 位作者 Zerui Li Siyang Li Ran Zhang Haocheng Li Hongfeng Yin Lei Lei Degao Wang Furong Liu Lin Li Yuxiang Liu Zhu Liu 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第7期375-389,I0010,共15页
Single-atom catalysts for CO2hydrogenation often deactivate due to structural instability under harsh reductive conditions.An amorphous-crystalline hybrid structured In2O3/Co3O4-based catalyst with Pt s... Single-atom catalysts for CO2hydrogenation often deactivate due to structural instability under harsh reductive conditions.An amorphous-crystalline hybrid structured In2O3/Co3O4-based catalyst with Pt single-atom implantation is innovatively synthesised by laser irradiation.In this work,a dynamic sacrificial-evolution-protection regulation strategy is proposed.The implanted Pt single-atoms,serving as active seeds,undergo migration and trigger reaction-induced dynamic evolution to generate sintering-resistant CoPt3and Co3InC0.75to prevent excessive reduction of In2O3to free metallic In.Concurrently,a self-constructed atomically ordered crystalline core-amorphous oxygen-enriched protective layer(AOL)contributes to anti-sintering,dynamic oxygen compensation,and stabilization of"HCOO intermediates.As a result,the catalyst achieves 16.21%±0.98% CO2conversion and 90.57%±1.02%CH3OH selectivity over 1000 h.This study elucidates the synergistic mechanism of laser-implanted single-atom catalysts,highlighting the dynamic evolution-driven retention of activity and stability,and establishes a direct correlation between the dynamic evolution of multicomponent structures and performance.This efficient and convenient laser solid-phase synthesis technique enables coupled design of single-atom implantation and dynamic regulation of multicomponent structures,offering a critical strategy for green methanol synthesis and the design of ultra-stable catalysts under extreme conditions. 展开更多
关键词 Laser synthesis Single-atom catalyst Oxygen vacancy CO2hydrogenation to methanol Stability Amorphous-crystalline Sintering
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Continuous fiber paths optimization for composite structures with stress and manufacturing constraints using a parametric level set method 认领 引用
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作者 Huiqiang Guo Zhengguang Li +2 位作者 Jiantao Bai Ran Zhang Wenjie Zuo 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2026年第4期361-382,共22页
Fiber-reinforced composite materials are widely used in engineering fields.The design of curvilinear fiber paths is significant for improving the mechanical and manufacturing performances of the composite materials.Th... Fiber-reinforced composite materials are widely used in engineering fields.The design of curvilinear fiber paths is significant for improving the mechanical and manufacturing performances of the composite materials.Therefore,this paper presents an optimization method for curvilinear fibers with stress and manufacturing constraints.The membrane-embedded model is adopted to simulate the composite materials because it does not require extensive constitutive tests.Curvilinear fiber paths are described using the parametric level set method,which naturally avoids the crossing of fiber tows.The fiber optimization model is to minimize structural compliance with stress and manufacturing constraints.Adjoint method is used to obtain the sensitivity information of the objective and constraint functions.Numerical examples demonstrate the effectiveness of the proposed optimization method.The structural stiffness of the optimized composites has been significantly increased while satisfying the stress and manufacturing constraints. 展开更多
关键词 Fiber-reinforced composite material Membrane-embedded model Curvilinear fiber optimization Parametric level set method
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Geochronology and petrogenesis of the mafic dykes from the Purang ophiolite:Implications for evolution of the western Yarlung-Tsangpo suture zone,southwestern Tibet 认领 引用 被引量：23
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作者 Fahui Xiong Yuanku Meng +4 位作者 Jingsui Yang Zhao Liu Xiangzhen Xu Alireza Eslami Ran Zhang 《Geoscience Frontiers》 SCIE CAS CSCD 2020年第1期277-292,共16页
The>2000 km Indus-Yarlung Tsangpo suture zone(IYSZ)is composed of the Neo-tethys oceanic remnants,flysch units and related continental rocks,which has been regarded as the boundary between the Eurasian and Indian t... The>2000 km Indus-Yarlung Tsangpo suture zone(IYSZ)is composed of the Neo-tethys oceanic remnants,flysch units and related continental rocks,which has been regarded as the boundary between the Eurasian and Indian terranes.Among the ophiolitic complexes,the Purang ophiolite is the biggest massif in the IYSZ,and many studies have been conducted on this ophiolite.However,previous studies have mainly focused on harzburgite,clinopyroxenite and dunite.Field observations show that mafic dykes were emplaced within the Purang ophiolite.However,petrogenetic evolutions of those mafic dykes are poorly understood.In this study,we present new LA-ICP-MS zircon U-Pb dating results,whole-rock geochemistry and Sr-Nd-Hf isotope analyses for microgabbro,gabbro and dolerite dykes from the Purang ophiolite of the southwestern IYSZ,respectively.Three samples yielded zircon U-Pb ages of144.2±2.1 Ma.127.9±2.3 Ma and 126.5±0.42 Ma,suggesting two different phases of magmatic activities distinctly.Whole-rock geochemical results suggest that the gabbro samples show alkaline features marked by enrichments of light rare earth elements(LREE)and large-ion lithophile elements(LILE),as well as Nb-Ta elements,suggesting an oceanic island basalt-like(OIB-like)geochemical affinity.However,the dolerite and microgabbro samples demonstrate sub-alkaline characteristics with normal mid-oceanic ridge basalt-like(N-MORB-like)geochemical features.Three distinct mafic dykes show significant Rb element depletion.The geochemical data and Sr-Nd-Hf isotopic features suggest that the microgabbro and gabbro rocks were derived from a depleted mantle that had been metasomatized by partial melts of sediments and enriched slab-derived fluids.The dolerite was also originated from a depleted mantle marked by significantly depleted Sr-Nd-Hf compositions,which was not influenced by enriched slab-derived fluids and sediments contamination during subsequent evolution.The isotope and geochemical data and tectonic diagrams suggest a tectonic transition from a within-plate to a midoceanic ridge basalt-like(MORB-like)setting during the period from ca.144 Ma to 127 Ma.Combined with regional background and this study,we propose that these mafic dykes were formed in an oceanic back-arc basin setting.Additionally,integrated with previous studies,we suggest that the geodynamic evolution of the southwestern and central parts of the Neo-Tethys oceanic basin is comparable in Early Cretaceous. 展开更多
关键词 Isotope geochemistry Mafic rocks Purang ophiolite Yarlung Tsangpo suture zone
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TOR balances plant growth and cold tolerance by orchestrating amino acid-derived metabolism in tomato 认领 引用 被引量：3
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作者 Zihao Li Lin Yang +3 位作者 Yanni Wu Ran Zhang Sen Yu Liwen Fu 《Horticulture Research》 SCIE CSCD 2024年第12期51-63,共13页
The target of rapamycin(TOR)kinase is a central signaling hub that plays a crucial role in precisely orchestrating plant growth,development,and stress responses.This suggests that TOR is intricately involved in mainta... The target of rapamycin(TOR)kinase is a central signaling hub that plays a crucial role in precisely orchestrating plant growth,development,and stress responses.This suggests that TOR is intricately involved in maintaining the balance between plant growth and stress responses.Nevertheless,despite the observed effects,the specific mechanisms through which TOR operates in these processes remain obscure.In this study,we investigated how the tomato(Solanum lycopersicum)TOR(SlTOR)affects plant growth and cold responses.We demonstrated that SlTOR inhibition transcriptionally primes cold stress responses,consequently enhancing tomato cold tolerance.A widely targeted metabolomics analysis revealed the disruption of amino acid metabolism homeostasis under cold stress upon SlTOR inhibition,which led to the accumulation of two important cryoprotective metabolites:salicylic acid(SA)and putrescine(Put).Next,we discovered SlPGH1(2-PHOSPHO-D-GLYCERATE HYDRO-LYASE1)as a direct substrate of SlTOR.Inhibiting SlTOR led to increased SlCBF1(C-REPEAT-BINDING FACTOR1)expression via SlPGH1,potentially triggering the activation of cold-responsive genes and subsequent metabolic alterations.Our study provides a mechanistic framework that elucidates how SlTOR modulates amino acid-related metabolism to enhance tomato cold tolerance,which sheds light on the complex interplay between growth and stress responses orchestrated by TOR. 展开更多
关键词 plant growth amino acid derived metabolism maintaining balance Solanum lycopersicum TOR metabolic homeostasis putrescine salicylic acid
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Antibiotics and probiotics differentially shape immunotherapy outcomes in non-small cell lung cancer 认领 引用
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作者 Shuling Ma Zijun Zhai +9 位作者 Rui Ding Shijie Shang Xinyi Liang Shan Yin Haofeng Lin Guomeng Sha Ran Zhang Jinming Yu Qian Song Dawei Chen 《Cancer Biology & Medicine》 SCIE CAS CSCD 2026年第5期703-716,共14页
The introduction of immune checkpoint inhibitors(ICIs)has substantially improved therapeutic outcomes in patients with non-small cell lung cancer(NSCLC)but marked inter-individual variability in treatment response per... The introduction of immune checkpoint inhibitors(ICIs)has substantially improved therapeutic outcomes in patients with non-small cell lung cancer(NSCLC)but marked inter-individual variability in treatment response persists. 展开更多
关键词 non small cell lung cancer probiotics immune checkpoint inhibitors icis immunotherapy antibiotics immune checkpoint inhibitors
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Unveiling the regulation of biochar and ferrihydrite on organic carbon stabilization,CH4 emission and microbial community in paddy soil 认领 引用
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作者 Ran Zhang Yujing Gu +9 位作者 Linrui Zhong Yuantao Xu Fanzhi Qin Hong Qin Qian Liu Jiali Cheng Jiahui Lei Jingwen Yan Yi Yin Yue Lu 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第6期283-293,共11页
Biochar(BC),an accessible and economic soil improvement,has influenced the biogeochemical cycling of iron and organic carbon(OC)in paddy soil.However,little is known about the effect of BC on iron-organic carbon(Fe-OC... Biochar(BC),an accessible and economic soil improvement,has influenced the biogeochemical cycling of iron and organic carbon(OC)in paddy soil.However,little is known about the effect of BC on iron-organic carbon(Fe-OC)associations,as well as how they regulate the associated microbial community in paddy soil.This study employed anoxic soil microcosms with distinct treatments including BC alone,ferrihydrite(Fh)alone,and BC combined with Fh.Results demonstrated that Fh alone significantly reduced CH4emission by suppressing key methanogens and stabilizing humic-like dissolved organic matter.BC alone slightly inhibited CH4while promoted CO2emission,consistent with its function as an electron shuttle promoting dissimilatory iron reduction and labile OC mineralization.Interestingly,the combined application of BC and Fh significantly suppressed the CH4emission.It might be due to that BC accelerated microbial iron reduction to divert electrons from methanogenesis and Fh preferentially sequestered humic-like organic components into mineral-associated complexes,which reduced substrate availability for methanogens(e.g.,Methanosarcina)while enriched iron-reducing bacteria like Thermoleophilia and Desulfuromonadia.This study revealed that the BC and Fh together had significant effects on the OC stabilization,CH4emission and microbial community,which provides fundamental information for future synergistic application of BC and Fh in rice paddy ecosystems. 展开更多
关键词 Iron minerals Biochar Organic carbon stabilization Paddy soil CH4emission
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Nanobody-based radiotracers in nuclear medicine:Advances,challenges,and future perspectives 认领 引用
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作者 Ying Yao Juan Tian +4 位作者 Ran Zhang Ping Liu Xiang Gao Wenhu Zhou Longlong Luo 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第6期78-86,共9页
Nuclear medicine imaging plays a critical role in early diagnosis,treatment planning,and monitoring by enabling real-time,non-invasive visualization of molecular processes.Conventional radiotracers,such as[18F]F-FD... Nuclear medicine imaging plays a critical role in early diagnosis,treatment planning,and monitoring by enabling real-time,non-invasive visualization of molecular processes.Conventional radiotracers,such as[18F]F-FDG,often suffer from limited specificity and unfavorable pharmacokinetics.Nanobodies,with their small size,high affinity,deep tissue penetration,and low immunogenicity,have emerged as valuable tools for molecular imaging.Nanobody-based radiotracers have shown promise across oncology,neurology,and immune-related diseases,supporting precision diagnostics and individualized treatment monitoring.However,challenges such as renal retention and short plasma half-life still hinder clinical translation.In this review,we present the structural and functional advantages of nanobodies and summarize the key advances,challenges,and future prospects of nanobody-based radiopharmaceuticals in nuclear medicine imaging. 展开更多
关键词 Nanobody Radiotracers Nuclear medicine imaging Radiopharmaceuticals Theranostics
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Unveiling molecular incomplete response(mIR)via ultradeep NGS:a novel concept contrasting pathologic complete response(pCR)in occult lymph node micrometastases of non-small cell lung cancer 认领 引用
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作者 Meng Lu Ran Zhang +5 位作者 Haidi Xu Bingsheng Sun Peng Chen Xuan Gao Meiming Zhong Jian You 《Cancer Biology & Medicine》 SCIE CAS CSCD 2026年第8期1198-1203,I0023-I0025,共6页
Accurate assessment of lymph node status is the cornerstone of staging and treatment decision-making in non-small cell lung cancer(NSCLC).Currently,conventional histopathology remains the gold standard.However,clinica... Accurate assessment of lymph node status is the cornerstone of staging and treatment decision-making in non-small cell lung cancer(NSCLC).Currently,conventional histopathology remains the gold standard.However,clinical reality presents the following challenge:30%–40%of patients with pathologic node-negative(pN0)disease eventually have a recurrence or distant metastasis1.While liquid biopsy[specifically circulating tumor DNA(ctDNA)-based molecular residual disease(MRD)detection]has revolutionized postoperative surveillance2,3,blood-based MRD reflects the systemic tumor burden and may lack sensitivity for detecting occult metastases within regional lymph nodes,which can act as“sanctuaries”for residual tumor cells.This issue is particularly pertinent in the era of neoadjuvant immunotherapy,during which some patients achieve a radiologic or even pathologic complete response(pCR)yet still relapse.These discrepancies raises two critical questions:Does conventional pathology underestimate staging due to limited sensitivity?Is“pCR”equivalent to“molecular complete clearance”?Systematic,deep molecular assessment of dissected lymph nodes may offer a unique perspective. 展开更多
关键词 assessment lymph node status Occult Lymph Node Micrometastases Non Small Cell Lung Cancer Lymph Node Status Molecular Incomplete Response Pathologic Complete Response liquid biopsy specifically circulating tumor dna ctdna based
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Specific Thermoresponsive Behaviours Exhibited by Optically Active and Inactive Phenylalanine Modified Hyperbranched Polyethylenimines in Water 认领 引用 被引量：1
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作者 Wu-cheng Fang Ran Zhang +2 位作者 Ye-feng Yao 刘华姬 陈宇 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2017年第8期1035-1042,共8页
Optically active and inactive hyperbranched polymers with specific thermoresponsive behaviours in water were reported.Through two steps hyperbranched polyethylenimine（HPEI） polymers terminated with different amount ... Optically active and inactive hyperbranched polymers with specific thermoresponsive behaviours in water were reported.Through two steps hyperbranched polyethylenimine（HPEI） polymers terminated with different amount of D-phenylalanine（D-Phe）,L-phenylalanine（L-Phe） or DL-phenylalanine（DL-Phe） were prepared and characterized.The analyses on the solution properties by turbidimetry,dynamic light scattering,fluorescence probe and 1H-NMR demonstrated that all the polymers exhibited specific thermoresponsive behaviours in water,including：（1） In the dilute polymer concentration region,increasing the polymer concentration led to the increase of phase transition temperature;（2） The optically inactive thermoresponsive hyperbranched polymers showed a higher cloud-point temperature（Tcp） than their corresponding optically active ones in a relatively higher polymer concentration;（3） At the same polymer concentration the hydrophobic groups of the optically inactive HPEI-DL-Phe formed more perfect hydrophobic domain than those of the optically active HPEI-L-Phe and HPEI-D-Phe. 展开更多
关键词 optically phenylalanine terminated hydrophobic inactive dilute Modified hydrophilic responsive solubility
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On large language models safety,security,and privacy:A survey 认领 引用 被引量：4
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作者 Ran Zhang Hong-Wei Li +2 位作者 Xin-Yuan Qian Wen-Bo Jiang Han-Xiao Chen 《Journal of Electronic Science and Technology》 EI CAS CSCD 2025年第1期1-21,共21页
The integration of artificial intelligence(AI)technology,particularly large language models(LLMs),has become essential across various sectors due to their advanced language comprehension and generation capabilities.De... The integration of artificial intelligence(AI)technology,particularly large language models(LLMs),has become essential across various sectors due to their advanced language comprehension and generation capabilities.Despite their transformative impact in fields such as machine translation and intelligent dialogue systems,LLMs face significant challenges.These challenges include safety,security,and privacy concerns that undermine their trustworthiness and effectiveness,such as hallucinations,backdoor attacks,and privacy leakage.Previous works often conflated safety issues with security concerns.In contrast,our study provides clearer and more reasonable definitions for safety,security,and privacy within the context of LLMs.Building on these definitions,we provide a comprehensive overview of the vulnerabilities and defense mechanisms related to safety,security,and privacy in LLMs.Additionally,we explore the unique research challenges posed by LLMs and suggest potential avenues for future research,aiming to enhance the robustness and reliability of LLMs in the face of emerging threats. 展开更多
关键词 Large language models Privacy issues Safety issues Security issues
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Profiling and functional characterization of long noncoding RNAs during human tooth development 认领 引用 被引量：2
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作者 Xiuge Gu Wei Wei +11 位作者 Chuan Wu Jing Sun Xiaoshan Wu Zongshan Shen Hanzhang Zhou Chunmei Zhang Jinsong Wang Lei Hu Suwen Chen Yuanyuan Zhang Songlin Wang Ran Zhang 《International Journal of Oral Science》 SCIE CAS CSCD 2025年第4期505-516,共12页
The regulatory processes in developmental biology research are significantly influenced by long non-coding RNAs(lncRNAs).However,the dynamics of lncRNA expression during human tooth development remain poorly understoo... The regulatory processes in developmental biology research are significantly influenced by long non-coding RNAs(lncRNAs).However,the dynamics of lncRNA expression during human tooth development remain poorly understood.In this research,we examined the lncRNAs present in the dental epithelium(DE)and dental mesenchyme(DM)at the late bud,cap,and early bell stages of human fetal tooth development through bulk RNA sequencing.Developmental regulators co-expressed with neighboring lncRNAs were significantly enriched in odontogenesis.Specific lncRNAs expressed in the DE and DM,such as PANCR,MIR205HG,DLX6-AS1,and DNM3OS,were identified through a combination of bulk RNA sequencing and single-cell analysis.Further subcluster analysis revealed lncRNAs specifically expressed in important regions of the tooth germ,such as the inner enamel epithelium and coronal dental papilla(CDP).Functionally,we demonstrated that CDP-specific DLX6-AS1 enhanced odontoblastic differentiation in human tooth germ mesenchymal cells and dental pulp stem cells.These findings suggest that lncRNAs could serve as valuable cell markers for tooth development and potential therapeutic targets for tooth regeneration. 展开更多
关键词 long noncoding RNAs dental mesenchyme developmental biology dental mesenchyme dm dental epithelium de bulk rna sequencingdevelopmental regulators human tooth development tooth development
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Multidimensional data-driven porous media reconstruction:Inversion from 1D/2D pore parameters to 3D real pores 认领 引用 被引量：2
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作者 Peng Chi Jian-Meng Sun +5 位作者 Ran Zhang Wei-Chao Yan Huai-Min Dong Li-Kai Cui Rui-Kang Cui Xin Luo 《Petroleum Science》 SCIE EI CAS CSCD 2025年第7期2777-2793,共17页
Subsurface rocks,as complex porous media,exhibit multiscale pore structures and intricate physical properties.Digital rock physics technology has become increasingly influential in the study of subsurface rock propert... Subsurface rocks,as complex porous media,exhibit multiscale pore structures and intricate physical properties.Digital rock physics technology has become increasingly influential in the study of subsurface rock properties.Given the multiscale characteristics of rock pore structures,direct three-dimensional imaging at sub-micrometer and nanometer scales is typically infeasible.This study introduces a method for reconstructing porous media using multidimensional data,which combines one-dimensional pore structure parameters with two-dimensional images to reconstruct three-dimensional models.The pore network model(PNM)is stochastically reconstructed using one-dimensional parameters,and a generative adversarial network(GAN)is utilized to equip the PNM with pore morphologies derived from two-dimensional images.The digital rocks generated by this method possess excellent controllability.Using Berea sandstone and Grosmont carbonate samples,we performed digital rock reconstructions based on PNM extracted by the maximum ball algorithm and compared them with stochastically reconstructed PNM.Pore structure parameters,permeability,and formation factors were calculated.The results show that the generated samples exhibit good consistency with real samples in terms of pore morphology,pore structure,and physical properties.Furthermore,our method effectively supplements the micropores not captured in CT images,demonstrating its potential in multiscale carbonate samples.Thus,the proposed reconstruction method is promising for advancing porous media property research. 展开更多
关键词 3D digital rock Pore network model 1D/2D pore parameters Pore structure Generative adversarial network
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Laser Solid-Phase Synthesis of Robust Single-Atom Catalysts for CO2Hydrogenation to Methanol 认领 引用 被引量：2
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作者 Rongxia Zhao Haocheng Li +10 位作者 Siyang Li Qin Wang Lei Lei Yuxiang Liu Ran Zhang Yihe Huang Hongfeng Yin Degao Wang Furong Liu Lin Li Zhu Liu 《Carbon Energy》 SCIE EI CSCD 2025年第9期28-40,共13页
The robustness of single-atom catalysts(SACs)is a critical concern for practical applications,especially for thermal catalysis at elevated temperatures under reductive conditions.In this study,a laser solid-phase synt... The robustness of single-atom catalysts(SACs)is a critical concern for practical applications,especially for thermal catalysis at elevated temperatures under reductive conditions.In this study,a laser solid-phase synthesis technique is reported to fabricate atom-nanoisland-sea structured SACs for the first time.The resultant catalysts are constructed by Pt single atoms on In2O3supported by Co3O4nanoislands uniformly dispersed in the sea of reduced graphene oxide.The laser process,with a maximum temperature of 2349 K within~100μs,produced abundant oxygen vacancies(up to 70.8%)and strong interactions between the Pt single atoms and In2O3.The laser-synthesized catalysts exhibited a remarkable catalytic performance towards CO2hydrogenation to methanol at 300°C with a CO2conversion of 30.3%,methanol selectivity of 90.6%and exceptional stability over 48 h without any deactivation,outperforming most of the relevant catalysts reported in the literature.Characterization of the spent catalysts after testing for 48 h reveals that the Pt single atoms were retained and the oxygen vacancies remained almost unchanged.In situ diffuse reflectance infrared Fourier transform spectrum was conducted to establish the reaction mechanism supported by the density functional theory simulations.It is believed that this laser synthesis strategy opens a new avenue towards rapidly manufacturing highly active and robust thermal SACs. 展开更多
关键词 CO2conversion CO2hydrogenation to methanol laser synthesis methanol selectivity single-atom catalysts stability
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Short-term P addition may improve the stimulating effects of N deposition on N2O emissions in alpine grasslands on the Qinghai-Tibetan Plateau 认领 引用 被引量：2
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作者 Jiannan Xiao Shikui Dong +7 位作者 Hao Shen Ran Zhang Hang Shi Fencai He Wei Li Xiaoyan Li YuLi Chengxiang Ding 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2025年第3期900-912,共13页
The response of N2O emissions to nitrogen(N)addition is usually positive,but its response to phosphorus(P)addition varies,and the underlying mechanisms for the changes in N2O emissions remain unclear.We conducte... The response of N2O emissions to nitrogen(N)addition is usually positive,but its response to phosphorus(P)addition varies,and the underlying mechanisms for the changes in N2O emissions remain unclear.We conducted field studies to examine the response of N2O emissions to N and P addition over two years in three typical alpine grasslands,alpine meadow(AM),alpine steppe(AS),and alpine cultivated grassland(CG)on the Qinghai-Tibet Plateau(QTP).Our results showed consistent increases in N2O emissions under N addition alone or with P addition,and insignificant change in N2O emissions under P addition alone in all three grasslands.N addition increased N2O emissions directly in AM,by lowering soil pH in AS,and by lowering abundance of denitrification genes in CG.N and P co-addition increased N2O emissions in AM and AS but only showed an interactive effect in AM.P addition enhanced the increase in N2O emissions caused by N addition mainly by promoting plant growth in AM.Overall,our results illustrate that short-term P addition cannot alleviate the stimulation of N2O emissions by N deposition in alpine grassland ecosystems,and may even further stimulate N2O emissions. 展开更多
关键词 Tibetan alpine grassland N2O emissions nitrogen phosphorus N-cycling functional gene
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Optimal feedback guidance with disturbance rejection for endoatmospheric powered descent 认领 引用 被引量：1
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作者 Xinglun CHEN Ran ZHANG Huifeng LI 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2025年第12期299-324,共26页
An optimal feedback guidance law with disturbance rejection objective is proposed for endoatmospheric powered descent.This guidance law with an affine form is derived by solving a novel problem called Endoatmospheric ... An optimal feedback guidance law with disturbance rejection objective is proposed for endoatmospheric powered descent.This guidance law with an affine form is derived by solving a novel problem called Endoatmospheric Powered Descent Guidance with Disturbance Rejection(Endo-PDG-DR).The key idea of formulating the Endo-PDG-DR problem is dividing disturbances into two parts,modeled and unmodeled disturbances:the modeled disturbance is proactively exploited by augmenting it as a new state of a dynamics model;the unmodeled disturbance is reactively attenuated in terms of its effect on the guidance performance by adjoining a parameterized time-varying quadratic performance index in the proposed optimal guidance problem.A Pseudospectral Differential Dynamic Programming(PDDP)method is developed to solve the Endo-PDG-DR problem,and correspondingly a robust neighboring optimal state feedback law is obtained,which has two synergistic functionalities.One is adaptive optimal steering to accommodate the modeled disturbance,and the other is disturbance attenuation to compensate for the state perturbation effect induced by the unmodeled disturbance.Using the derived feedback guidance law,a disturbance rejection level is quantified,and is correspondingly optimized by designing a quadratic weighting parameter tuning law.The numerical computations of interest are performed within a pseudospectral setting,ensuring polynomial analytical solution,high computational efficiency,and reliable convergence. 展开更多
关键词 Reusable rockets Powered descent Optimal control systems Disturbance rejection Differential dynamic programming
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Fault Tolerant Neuro-Robust Position Control of DC Motors 认领 引用 被引量：1
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作者 Ran Zhang Marwan Bikdash 《Journal of Electromagnetic Analysis and Applications》 2011年第10期412-415,共4页
DC motors are widely used in industry such as mechanics, robotics, and aerospace engineering. In this paper, we present a high performance control method for position control of DC motors. Fault-tolerant control model... DC motors are widely used in industry such as mechanics, robotics, and aerospace engineering. In this paper, we present a high performance control method for position control of DC motors. Fault-tolerant control model are also addressed to combine with neuro-robust control approach. It is shown that with the proposed control algorithms, external disturbances and coupled dynamics inherent in the system are effectively compensated using neural network unit in which no analytical estimation on the upper bound of the reconstruction error and uncertainties is needed. Simulations on various flight conditions also confirm the effectiveness of the proposed methods. 展开更多
关键词 Fault-Tolerant Neuro-Robust Position Control DC Motors
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Time exploration of initiating letermovir for the prevention of cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation 认领 引用 被引量：1
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作者 Ran Zhang Mengyang Zhu +8 位作者 Luxiang Wang Ni Liao Xueqi Xie Jingjing Heng Yang Cao Xiaoxia Hu Wei Shi Zhilei Bian Weijie Cao 《Chinese Medical Journal》 SCIE CAS CSCD 2026年第12期1882-1884,共3页
To the Editor:Cytomegalovirus(CMV)infection remains a leading cause of morbidity and mortality in allogeneic hematopoietic stem cell transplantation(allo-HSCT)recipients,particularly in high-risk populations with huma... To the Editor:Cytomegalovirus(CMV)infection remains a leading cause of morbidity and mortality in allogeneic hematopoietic stem cell transplantation(allo-HSCT)recipients,particularly in high-risk populations with human leukocyte antigen(HLA)mismatch,haploidentical donors,or intensive conditioning regimens.[1]Letermovir,a selective inhibitor of the CMV terminase complex,has demonstrated efficacy in reducing CMV reactivation in phase 3 trials.[2]However,the optimal time for initiating letermovir prophylaxis post-transplantation remains unclear,with clinical practices varying widely between institutions.Here,we report a multicenter retrospective study evaluating the impact of letermovir initiation timing on clinically significant CMV infection(csCMVi)in highrisk patients with allo-HSCT. 展开更多
关键词 reducing cmv reactivation prophylaxis high risk patients human leukocyte letermovir intensive conditioning regimens letermovira allo hsct cytomegalovirus infection
Parameterized evasion strategy for hypersonic glide vehicles against two missiles based on reinforcement learning 认领 引用
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作者 Zeming HAO Ran ZHANG Huifeng LI 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2025年第4期450-468,共19页
In practical combat scenarios,Hypersonic Glide Vehicles(HGV)face the challenge of evading Successive Pursuers from the Same Direction while satisfying the Homing Constraint(SPSDHC).To address this problem,this paper p... In practical combat scenarios,Hypersonic Glide Vehicles(HGV)face the challenge of evading Successive Pursuers from the Same Direction while satisfying the Homing Constraint(SPSDHC).To address this problem,this paper proposes a parameterized evasion guidance algorithm based on reinforcement learning.The three-player optimal evasion strategy is firstly analyzed and approximated by parametrization.The switching acceleration command of HGV optimal evasion strategy considering the upper limit of missile acceleration command is analyzed based on the optimal control theory.The terminal miss of HGV in the case of evading two missiles is analyzed,which means that the three-player optimal evasion strategy is a linear combination of two one-toone strategies.Then,a velocity control algorithm is proposed to increase the terminal miss by actively controlling the flight speed of the HGV based on the parametrized evasion strategy.The reinforcement learning method is used to implement the strategy in real time and a reward function is designed by deducing homing strategy for the HGV to approach the target,which ensures that the HGV satisfies the homing constraint.Experimental results demonstrate the feasibility and robustness of the proposed parameterized evasion strategy,which enables the HGV to generate maximum terminal miss and satisfy homing constraint when facing single or double missiles. 展开更多
关键词 Hypersonic glide vehicle Optimal control theory Evasion strategy Three players Reinforcement learning
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