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Reactive nano-essential oils for sustained release of essential oils and application to wallpaper 认领 引用 被引量：4
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作者 Qiulian Hao Huan Peng +9 位作者 Ruichen Zhao Jianze Wang Zhiguo Lu Jingwen Wang Jie Shen Yunwei Niu Zuobing Xiao Guiying Liu Jifu Hao Xin Zhang 《Chinese Chemical Letters》 SCIE CAS CSCD 2022年第1期320-323,共4页
Essential oils are a volatile and aromatic substance with a variety of active biological activities.However,the excessive volatility and inconvenience of the use of essential oils limit their applications.In this stud... Essential oils are a volatile and aromatic substance with a variety of active biological activities.However,the excessive volatility and inconvenience of the use of essential oils limit their applications.In this study,we developed a reactive mesoporous silica nanoparticle(rMSNs)based on cyanuric chloride modification for essential oil encapsulation and commodity adhesion.The large pore volume and specific surface area of rMSNs facilitate the nanoparticles adhering to a large amount of essential oil and achieve the sustained release of essential oil,thus prolonging the fragrance retention time of essential oils.The reactive nanoessential oils can form covalent bonds with the wallpaper,thereby remarkably improving the adhesion of the reactive nano-essential oils on the wallpaper and preventing the reactive nano-essential oil from deadhering from the wallpaper.The active nano essential oil simultaneously overcomes the intense volatility of the essential oil and inconvenience in use,has a simple preparation process and low cost,and has great application potential. 展开更多
关键词 Reactive nano-essential oils Reactive mesoporous silica nanoparticles Slow-release of essential oils Application to wallpaper Covalent bonds
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Advances in oral peptide drug nanoparticles for diabetes mellitus treatment 认领 引用 被引量：10
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作者 Yan Li Wen Zhang +1 位作者 Ruichen Zhao Xin Zhang 《Bioactive Materials》 SCIE CSCD 2022年第9期392-408,共17页
Peptide drugs play an important role in diabetes mellitus treatment.Oral administration of peptide drugs is a promising strategy for diabetes mellitus because of its convenience and high patient compliance compared to... Peptide drugs play an important role in diabetes mellitus treatment.Oral administration of peptide drugs is a promising strategy for diabetes mellitus because of its convenience and high patient compliance compared to parenteral administration routes.However,there are a series of formidable unfavorable conditions present in the gastrointestinal(GI)tract after oral administration,which result in the low oral bioavailability of these peptide drugs.To overcome these challenges,various nanoparticles(NPs)have been developed to improve the oral absorption of peptide drugs due to their unique in vivo properties and high design flexibility.This review discusses the unfavorable conditions present in the GI tract and provides the corresponding strategies to overcome these challenges.The review provides a comprehensive overview on the NPs that have been constructed for oral peptide drug delivery in diabetes mellitus treatment.Finally,we will discuss the rational application and give some suggestions that can be utilized for the development of oral peptide drug NPs.Our aim is to provide a systemic and comprehensive review of oral peptide drug NPs that can overcome the challenges in GI tract for efficient treatment of diabetes mellitus. 展开更多
关键词 Oral nanoparticles Peptide drugs Gastrointestinal tract Diabetes mellitus Oral bioavailability
Smart antioxidant function enhancing(SAFE)nucleic acid therapy for ROS-related chronic diseases and comorbidities 认领 引用 被引量：3
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作者 Zhiguo Lu Ruichen Zhao +12 位作者 Yi Li Jianze Wang Jing Guo Chaobo Bai Jing Chen Jun Yang Yiwan Geng Tianlu Zhang Yanyue Wu Xiyue Jiao Yining Wang Junliang Yuan Xin Zhang 《Bioactive Materials》 SCIE CSCD 2024年第1期509-524,共16页
Reactive oxygen species(ROS)-mediated oxidative stress exacerbates chronic diseases such as organ damage and neurodegenerative disorders.The Keap1-Nrf2-ARE pathway is a widely distributed endogenous antioxidant system... Reactive oxygen species(ROS)-mediated oxidative stress exacerbates chronic diseases such as organ damage and neurodegenerative disorders.The Keap1-Nrf2-ARE pathway is a widely distributed endogenous antioxidant system.However,ROS under redox homeostasis regulates a wide range of life activities.Therefore,smart scavenging of excess ROS under pathological conditions is essential to treat chronic diseases safely.This study reports a smart antioxidant function enhancement(SAFE)strategy.On-demand release of nucleic acid drugs in a pathological ROS environment smartly activates the endogenous antioxidant system,thereby smartly alleviating oxidative stress in an exogenous antioxidant-independent manner.Through structural modulation and ligand modification,we develop SAFE nanoparticles based on nanohybrid complexes(SAFE-complex)adapted to brain delivery of nucleic acid drugs.SAFE-complex with homogeneous monodisperse structure efficiently treat ROS-related neurodegenerative diseases while protecting the major organ from oxidative stress damage.Moreover,SAFE-complex can stabilize storage in the form of freeze-dried powder.These data indicate that SAFE nanoparticles hold promise for treating ROS-related chronic diseases and comorbidities through rational transformation. 展开更多
关键词 Smart antioxidant function enhancing(SAFE)strategy Reactive oxygen species Nucleic acid drugs Keap1-Nrf2-ARE pathway ROS-Associated chronic diseases and comorbidities
A STIR nucleic acid drug delivery system for stirring phenotypic switch of microglia in Parkinson’s disease treatments 认领 引用
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作者 Yanyue Wu Wenli Wang +9 位作者 Xinyu Qiu Zhiguo Lu Weihong Ji Jie Shen Huan Peng Ruichen Zhao Jingwen Wang Tianlu Zhang Jun Yang Xin Zhang 《Nano Research》 SCIE EI CSCD 2023年第5期7216-7226,共11页
Neuroinflammation is one of the three important pathological features in neurodegenerative diseases including Parkinson’s disease(PD).The regulation of neuroinflammation can reduce the severity of neurological damage... Neuroinflammation is one of the three important pathological features in neurodegenerative diseases including Parkinson’s disease(PD).The regulation of neuroinflammation can reduce the severity of neurological damage to alleviate diseases.Numerous studies have shown that the phenotype switch of microglia is tightly associated with the nuclear factorκB(NF-κB)-mediated inflammatory pathway.Therefore,the small interfering RNA(siRNA)therapy for downregulating the expression of NF-κB,provides a promising therapeutic strategy for Parkinson’s disease treatments.Considering the brain delivery challenges of siRNA,a sequential targeting inflammation regulation(STIR)delivery system based on poly(amino acid)s is developed to improve the therapeutic effects of Parkinson’s disease treatments.The STIR system sequentially targets the blood–brain barrier and the microglia to enhance the effective concentration of siRNA in the targeted microglia.The results demonstrate that the STIR nanoparticles can transform microglial phenotypes and regulate brain inflammation,thus achieving neuronal recovery and abnormal aggregation ofα-synuclein protein(α-syn)reduction in the treatment of Parkinson’s disease.Herein,this STIR delivery system provides a promising therapeutic platform in PD treatments and has great potential for other neurodegenerative diseases’therapies. 展开更多
关键词 sequential targeting inflammation regulation phenotypic switch of microglia targeted drug delivery siRNA-based gene therapy responsive release Parkinson’s disease
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生物启发和生物工程核酸药物载体 认领 引用 被引量：4
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作者 左嘉敏 卢治国 +7 位作者 郭京 赵睿琛 张田露 王朝霞 袁云 邓健文 袁俊亮 张欣 《Science China Materials》 SCIE EI CAS CSCD 2024年第8期2393-2413,共21页
核酸药物具有直接作用于致病基因的优势,在治疗各种疾病方面具有巨大潜力.然而,由于核酸药物需要克服多重生理障碍才能到达靶点,因此在实际应用中面临诸多困难和挑战.为了提高核酸药物的稳定性和递送效率,研究人员开始利用生物工程化和... 核酸药物具有直接作用于致病基因的优势,在治疗各种疾病方面具有巨大潜力.然而,由于核酸药物需要克服多重生理障碍才能到达靶点,因此在实际应用中面临诸多困难和挑战.为了提高核酸药物的稳定性和递送效率,研究人员开始利用生物工程化和生物启发材料所具有的内源性递送生物大分子的能力来递送核酸药物.本文重点介绍核酸药物递送过程中需要克服的生物障碍,以及生物工程和生物启发材料在核酸药物递送中的优势和应用.通过利用这些先进的生物材料,研究人员有望提高核酸药物的疗效,为疾病治疗提供新的解决方案. 展开更多
关键词 生物工程 药物递送 生理障碍 生物启发 致病基因 生物大分子 工程化 疾病治疗
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