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Association between prediabetes and higher risk of mortality following acute ischemic stroke:A meta-analysis 认领 引用
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作者 Bhavin Patel Kshitij Mahajan +5 位作者 Arankesh Mahadevan Rishika Trivedi Avleen Dhingra Samrath Singh Brar Sakshi Dixit Rupak Desai 《World Journal of Diabetes》 SCIE 2026年第1期203-210,共8页
BACKGROUND Prediabetes increases the risk of cardiovascular and cerebrovascular mortality.This study examines the relationship between prediabetes and mortality in poststroke patients.AIM To determine whether prediabe... BACKGROUND Prediabetes increases the risk of cardiovascular and cerebrovascular mortality.This study examines the relationship between prediabetes and mortality in poststroke patients.AIM To determine whether prediabetes is associated with increased post-stroke mortality in adults with acute ischemic stroke(IS).METHODS A systematic search was conducted in PubMed/MEDLINE,Scopus,and Google Scholar databases until May 2023 to identify relevant articles reporting on the association of prediabetes with IS mortality.A random-effects model was used to calculate odds ratio(OR),heterogeneity was assessed using I2 statistics,and sensitivity analysis was performed using the leave-one-out method.RESULTS Our analysis of 11 studies included 84833 prediabetic patients with a mean follow-up time of 20.9 months.The prediabetes cohort comprised patients of an average age of 67 years from various countries,including Korea,Italy,Japan,China,Spain,and the Netherlands.Although,the unadjusted analysis showed no significant association between prediabetes and post-stroke mortality(OR=1.06,95%CI:0.51-2.19)with high heterogeneity(I2=94.7%,P<0.01).Post-adjustment for baseline characteristics and comorbidities,the prediabetes cohort exhibited a significantly higher risk of post-stroke mortality(adjusted OR=1.68,95%CI:1.29-2.19)with moderate heterogeneity(I2=49.45%,P=0.03).Subgroup analysis by country revealed non-significant higher odds of mortality in Korea,Italy,Spain,Japan,and the Netherlands,indicating the need for more extensive studies.CONCLUSION Our findings suggest that prediabetes is associated with a nearly 68%higher mortality risk following a stroke.Thereby warranting more prospective studies with prediabetes to validate these findings. 展开更多
关键词 Meta-analysis Prediabetes Hyperglycemia Stroke Mortality
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Association of cannabis use disorder with atrial fibrillation in young men without concomitant tobacco use:Insights from nationwide propensity matched analysis 认领 引用
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作者 Bhavin Patel Sumanth Khadke +7 位作者 Kshitij Mahajan Avleen Dhingra Rishika Trivedi Samrath Singh Brar Sakshi Dixit Vaibhav Periwal Shaylika Chauhan Rupak Desai 《World Journal of Experimental Medicine》 2024年第3期64-71,共8页
BACKGROUND Recent data are inconclusive regarding the risk of arrhythmias among young cannabis users.Furthermore,many young adults use both cannabis and tobacco,which could add a residual confounding effect on outcome... BACKGROUND Recent data are inconclusive regarding the risk of arrhythmias among young cannabis users.Furthermore,many young adults use both cannabis and tobacco,which could add a residual confounding effect on outcomes.So,we studied young men who have cannabis use disorder(CUD)excluding tobacco use disorder(TUD)to understand their independent association with atrial fibrillation(AF)and related outcomes.AIM To study the association of CUD with AF and related outcomes.METHODS We used weighted discharge records from National Inpatient Sample(2019)to assess the baseline characteristics and mortality rates for AF-related hospitalizations in young(18-44 years)men in 1:1 propensity-matched CUD+vs CUD-cohorts without TUD.RESULTS Propensity matched CUD+and CUD-cohorts consisted of 108495 young men in each arm.Our analysis showed an increased incidence of AF in black population with CUD.In addition,the CUD+cohort had lower rates of hyperlipidemia(6.4%vs 6.9%),hypertension(5.3%vs 6.3%),obesity(9.1%vs 10.9%),alcohol abuse(15.5%vs 16.9%),but had higher rates of anxiety(24.3%vs 18.4%)and chronic obstructive pulmonary disease(COPD)(9.8%vs 9.4%)compared to CUD-cohort.After adjustment with covariates including other substance abuse,a non-significant association was found between CUD+cohort and AF related hospitalizations(odd ratio:1.27,95%confidence interval:0.91-1.78,P=0.15).CONCLUSION Among hospitalized young men,the CUD+cohort had a higher prevalence of anxiety and COPD,and slightly higher proportion of black patients.Although there were higher odds of AF hospitalizations in CUD+cohort without TUD,the association was statistically non-significant.The subgroup analysis showed higher rates of AF in black patients.Large-scale prospective studies are required to evaluate long-term effects of CUD on AF risk and prognosis without TUD and concomitant substance abuse. 展开更多
关键词 Cannabis Marijuana Atrial fibrillation Tobacco use disorder Original research Smoking
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