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Innovative Approaches to Pretreatment and Modification of Sewage Sludge-Derived Biochar for Resource Recovery:A Short Review 认领 引用
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作者 Vijendra Singh Tanwar Santosh Kumar Singh +1 位作者 Jitendra Kumar Sharma Ritesh Patidar 《Journal of Building Material Science》 CAS 2025年第3期206-219,共14页
The uptake of biochar from sewage sludge has developed into a critical avenue for resource reclamation whilst solving waste disposal concerns.However,despite the latter side in environmental palliative,the use of this... The uptake of biochar from sewage sludge has developed into a critical avenue for resource reclamation whilst solving waste disposal concerns.However,despite the latter side in environmental palliative,the use of this biochar for remediation,recovery of nutrients,or adsorption of pollutants is often suboptimal due to poor surface area,high percentage of ash and functional group scarcity.Sewage sludge-derived biochar(SSB)has emerged as a promising material for resource recovery,environmental remediation,and sustainable waste management.This review paper scopes out the recent developments in the field of sludge derived biochar and focuses on the advances in hydrothermal carbonization biochar and its modified forms.Pretreatment methods such as hydrothermal carbonization,enzymatic treatment,ultrasonic,and acid/base wash are looked into in order to improve the purity and the characteristics of the feedstock.Post the structural adjustments some of the molecular modification methods are implemented using KOH,ZnCl2 and H3PO4 for chemical activation,doping with Fe/Mn or Mg,and thermal and microwave processes which are aimed at increasing porosity,adsorption and catalytic activity.The review also evaluates the combination of various methods to fabricate multifunctional biochar for applications such as phosphate recycling,heavy metals and carbon absorption and utilization,as well as the application of biochar as catalysts in advanced oxidation processes. 展开更多
关键词 Geotechnical Properties Municipal Sewage Sludge Particle size Distribution Treatment Process
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Sitagliptin,sitagliptin and metformin,or sitagliptin and amitriptyline attenuate streptozotocin-nicotinamide induced diabetic neuropathy in rats 认领 引用 被引量：3
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作者 Ashish Kumar Sharma Akash Sharma +24 位作者 Rita Kumari Kunal Kishore Divya Sharma Bharthu Parthsarthi Srinivasan Ashok Sharma Santosh Kumar Singh Samir Gaur Vijay Singh Jatav Prashant Sharma Varnika Srivastava Sneha Joshi Megha Joshi Prashant Kumar Dhakad Davender Singh Kanawat Akanksha Mishra Anil Sharma Dharmendra Singh Ravinder Pal Singh Himmat Singh Chawda Rambir Singh Sachin Kumar Raikwar Muneem Kumar Kurmi Pankaj Khatri Ashutosh Agarwal Arshee Munajjam 《Journal of Biomedical Research》 CAS 2012年第3期200-210,共11页
Diabetic neuropathies are a family of nerve disorders caused by diabetes. Symptoms of the disease include nerve palsy, mononeuropathy, mononeuropathy multiplex, diabetic amyotrophy, painful polyneuropathy, autonomic n... Diabetic neuropathies are a family of nerve disorders caused by diabetes. Symptoms of the disease include nerve palsy, mononeuropathy, mononeuropathy multiplex, diabetic amyotrophy, painful polyneuropathy, autonomic neu- ropathy, and thoracoabdominal neuropathy. In this study, type 2 diabetes in rats was induced with nicotinamide- streptozotocin. Drug treatment was initiated on the d 15, with the combination regimen of metformin, pioglitazone and glimipiride or metformin and sitagliptin or sitagliptin, amitriptyline and sitagliptin and led to significantly im- proved glycemic control, increased grip strength and paw jumping response on d 21, 28 and 35 （P 〈 0.001）. Signif- icant increases in blood protein levels and decreases in urinary protein levels were observed in the animals treated with the different regimens on d 21, 28 and 35 （P 〈 0.001）. Combined treatment of streptozotocin and nicotinamide caused marked degeneration of nerve cells, while administration of metformin and sitagliptin showed tissue regen- eration and no body weight gain. In conclusion, treatment with sitagliptin and sitagliptin combined with metformin or amitriptyline results in no body weight gain, but causes an increase in grip strength and pain sensitivity, exhibits neural protection, and reverses the alteration of biochemical parameters in rats with streptozotocin-nicotinamide induced type 2 diabetes. 展开更多
关键词 diabetic neuropathy nicotinamide-streptozotocin metformin pioglitazone glimipiride sitagliptin amitriptyline
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Cardioprotective activity of alcoholic extract of Tinospora cordifolia (Willd.) Miers in calcium chloride-induced cardiac arrhythmia in rats 认领 引用 被引量：3
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作者 Ashish Kumar Sharma Kunal Kishore +6 位作者 Divya Sharma B.P Srinivasan Shyam Sunder Agarwal Ashok Sharma Santosh Kumar Singh Samir Gaur Vijay Singh Jatav 《Journal of Biomedical Research》 CAS 2011年第4期280-286,共7页
The present study investigated the antiarrhythmic activity of alcoholic extract of Tinospora cordifolia （T. cordifolia） in CaCl2 induced arrhythmia. CaCl2 （25 mg/kg） was administered by intravenous infusion （iv）... The present study investigated the antiarrhythmic activity of alcoholic extract of Tinospora cordifolia （T. cordifolia） in CaCl2 induced arrhythmia. CaCl2 （25 mg/kg） was administered by intravenous infusion （iv） to produce arrhythmia in rats. The animals were then treated with T. cordifolia extract （150, 250, and 450 mg/kg） and verapamil （5 mg/kg,iv）. Lead II electrocardiogram was monitored. Plasma calcium, sodium and potassium levels were measured. In CaCl2 induced arrhythmia, heart rate was decreased by 41.10%, T. cordifolia at 150, 300, and 450 mg/kg decreased the heart rate by 26.30%, 29.16%, and 38.29%, respectively, and verapamil reduced the heart rate by 9.70% compared to the normal group. The PQRST waves were normalized and atrial and ventricular fibrillation was controlled in rats treated with verapamil and T. cordifolia. CaCl2 increased calcium and sodium levels and decreased potassium levels in blood. T. cordifolia dose-dependently decreased calcium and sodium levels and increased potassium levels. Hence, T. cordifolia can be used in antiarrhythmic clinical settings and beneficial in atrial and ventricular fibrillation and flutter and may be indicated in ventricular tachyarrhythmia. 展开更多
关键词 Tinospora cordifolia arrhythmia cardioprotection.
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Involvement of adenosine and standardization of aqueous extract of garlic(Allium sativum Linn.)on cardioprotective and cardiodepressant properties in ischemic preconditioning and myocardial ischemia-reperfusion induced cardiac injury 认领 引用 被引量：1
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作者 Ashish Kumar Sharma Arshee Munajjam +12 位作者 Bhawna Vaishnav Richa Sharma Ashok Sharma Kunal Kishore Akash Sharma Divya Sharma Rita Kumari Ashish Tiwari Santosh Kumar Singh Samir Gaur Vijay Singh Jatav Barthu Parthi Srinivasan Shyam Sunder Agarwal 《Journal of Biomedical Research》 CAS 2012年第1期24-36,共13页
The present study investigated the effect of garlic （Allium sativum Linn.） aqueous extracts on ischemic pre- conditioning and ischemia-reperfusion induced cardiac injury, as well as adenosine involvement in ischemic... The present study investigated the effect of garlic （Allium sativum Linn.） aqueous extracts on ischemic pre- conditioning and ischemia-reperfusion induced cardiac injury, as well as adenosine involvement in ischemic pre- conditioning and garlic extract induced cardioprotection. A model of ischemia-reperfusion injury was established using Langendorff apparatus. Aqueous extract of garlic dose was standardized （0.5%, 0.4%, 0.3%, 0.2%, 0.1%, 0.07%, 0.05%, 0.03%, 0,01%）, and the 0.05% dose was found to be the most effective. Higher doses （more than 0.05%） were highly toxic, causing arrhythmia and cardiodepression, whereas the lower doses were ineffective. Garlic exaggerated the cardioprotective effect of ischemic preconditioning. The cardioprotective effect of ischemic preconditioning and garlic cardioprotection was significantly attenuated by theophylline （1,000 ~tmol/L） and 8-SPT （10 mg/kg, i.p.） and expressed by increased myocardial infarct size, increased LDH level, and reduced nitrite and adenosine levels. These findings suggest that adenosine is involved in the pharmacological and molecular mechanism of garlic induced cardioprotection and mediated by the modulation of nitric oxide. 展开更多
关键词 Allium sativum Linn. ischemic preconditioning cardioprotection adenosine nitrite
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A Case Report of Pediatric Cerebral Venous Thrombosis with Undiagnosed Complex Congenital Heart Disease: Tetralogy of Fallot with OS ASD: A Cataclysmic Ending 认领 引用
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作者 Sayani Banerjee Aishwarya Nandy Santosh Kumar Singh 《Open Journal of Emergency Medicine》 2022年第2期111-123,共13页
Cerebral Venous Sinus Thrombosis (CVST/CSVT) is occlusion of cerebral veins and venous sinuses of brain secondary to blood clot formation resulting in hindrance in the blood drainage system in brain, leading to distur... Cerebral Venous Sinus Thrombosis (CVST/CSVT) is occlusion of cerebral veins and venous sinuses of brain secondary to blood clot formation resulting in hindrance in the blood drainage system in brain, leading to disturbances the internal homeostasis of brain, raised intracranial pressure, cerebral edema, and 50% of cases will have venous infarction or venous hemorrhage (stroke). CVST although being a Rare disorder but may be more common in children than adults with greater risk in neonatal period i.e. first 28 days of life. Here we are discussing a case of Pediatric CVST in a 7-month-old baby boy who presented to Emergency Room (ER) with recurrent discrete episodes of vomiting, fever, seizures, drowsiness and respiratory distress. The fatal outcome in our child was attributed to delayed presentation in a tertiary care center, hence missed early diagnosis and treatment. In this child the CVST could be result of amalgamation of complex underlying ongoing multiple pathological processes: an acute systemic illness like sepsis, severe dehydration, undiagnosed and untreated complex congenital heart disease, tetralogy of fallot with osteum secondum atrial septal defect, worsening the coagulopathy. It takes this case even more unique. This discussion is to bring focus on the importance of knowledge about CVST amongst emergency physicians and primary care physicians, specially managing this rare disorder with flummox presentation mimicking other more common disorders, especially in pediatric and neonatal population where definitive history and chief complaints are often vague and difficult to obtain, making it more difficult to diagnose. We the authors hence reporting this case with intent to spread awareness of CVST, how to doubt it, detect it and then manage it, especially in places like Chhattisgarh, India, where CVST is not so uncommon. We believe early diagnosis, early presentation to tertiary care center with aggressive early treatment can significantly reduce the mortality. Should the parents brought the baby early to any tertiary care center owing to his complex deteriorating symptoms like high grade fever progressed to drowsiness and seizure episodes, could there be a different outcome for this child as well as his parents. 展开更多
关键词 Cerebral Venous Sinus Thrombosis (CVST) Pediatric CVST Tetralogy of Fallot (TOF) Osteum Secondum Atrial Septal Defect (OS ASD)
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Plant associated fungal endophytes as a source of natural bioactive compounds 认领 引用 被引量：5
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作者 Nilesh Rai Priyanka Kumari Keshri +5 位作者 Ashish Verma Swapnil C.Kamble Pradeep Mishra Suvakanta Barik Santosh Kumar Singh Vibhav Gautam 《Mycology》 2021年第3期139-159,共21页
Endophytes are a potent source of bioactive compounds that mimic plant-based metabolites.The relationship of host plant and endophyte is significantly associated with alteration in fungal colonisation and the extracti... Endophytes are a potent source of bioactive compounds that mimic plant-based metabolites.The relationship of host plant and endophyte is significantly associated with alteration in fungal colonisation and the extraction of endophyte-derived bioactive compounds.Screening of fungal endophytes and their relationship with host plants is essential for the isolation of bioactive compounds.Numerous bioactive compounds with antioxidant,antimicrobial,anticancer,and immunomodulatory properties are known to be derived from fungal endophytes.Bioinformatics tools along with the latest techniques such as metabolomics,next-generation sequencing,and metagenomics multilocus sequence typing can potentially fill the gaps in fungal endophyte research.The current review article focuses on bioactive compounds derived from plantassociated fungal endophytes and their pharmacological importance.We conclude with the challenges and opportunities in the research area of fungal endophytes. 展开更多
关键词 Fungal endophyte bioactive compound host endophytes relationship biological activity
Epigenetic manipulation for secondary metabolite activation in endophytic fungi:current progress and future directions 认领 引用 被引量：1
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作者 Ashish Verma Harshita Tiwari +6 位作者 Swati Singh Priyamvada Gupta Nilesh Rai Santosh Kumar Singh Bhim Pratap Singh Sombir Rao Vibhav Gautam 《Mycology》 2023年第4期275-291,共17页
Fungal endophytes have emerged as a promising source of secondary metabolites with significant potential for various applications in the field of biomedicine.The biosynthetic gene clusters of endophytic fungi are resp... Fungal endophytes have emerged as a promising source of secondary metabolites with significant potential for various applications in the field of biomedicine.The biosynthetic gene clusters of endophytic fungi are responsible for encoding several enzymes and transcriptional factors that are involved in the biosynthesis of secondary metabolites.The investigation of fungal metabolic potential at genetic level faces certain challenges,including the synthesis of appropriate amounts of chemicals,and loss of the ability of fungal endophytes to produce secondary metabolites in an artificial culture medium.Therefore,there is a need to delve deeper into the field of fungal genomics and transcriptomics to explore the potential of fungal endophytes in generating secondary metabolites governed by biosynthetic gene clusters.The silent biosynthetic gene clusters can be activated by modulating the chromatin structure using chemical compounds.Epigenetic modification plays a significant role by inducing cryptic gene responsible for the production of secondary metabolites using DNA methyl transferase and histone deacetylase.CRISPR-Cas9-based genome editing emerges an effective tool to enhance the production of desired metabolites by modulating gene expression.This review primarily focuses on the significance of epigenetic elicitors and their capacity to boost the production of secondary metabolites from endophytes.This article holds the potential to rejuvenate the drug discovery pipeline by introducing new chemical compounds. 展开更多
关键词 Fungal endophytes chromatin histone modification bioactive compounds secondary metabolites
Erratum to:Lubrication of dry sliding metallic contacts by chemically prepared functionalized graphitic nanoparticles 认领 引用 被引量：1
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作者 Suprakash SAMANTA Santosh Kumar SINGH Rashmi R.SAHOO 《Friction》 SCIE EI CAS CSCD 2020年第4期812-812,共1页
Erratum to Friction 8(4):708-725(2020)DO110.1007/s40544-019-0295-1 The original version of this article unfortunately contained incorrect author's name and address.On the first page of this article,instead of Supr... Erratum to Friction 8(4):708-725(2020)DO110.1007/s40544-019-0295-1 The original version of this article unfortunately contained incorrect author's name and address.On the first page of this article,instead of Suprakash SAMANTA1,2,Santosh SINGH1,Rashmi R.SAHOO1,2,*Surface Engineering&Tribology Division,CSIR-Central Mechanical Engineering Research lnstitute,Durgapur 713209,India Academry of Sciertific ard Iovative Research(AcSIR),Ghaziabad 201002,India. 展开更多
关键词 Friction metallic Lubrication
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Flow past a bluff body subjected to lower subcritical Reynolds number 认领 引用 被引量：2
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作者 Pankaj Kumar Santosh Kumar Singh 《Journal of Ocean Engineering and Science》 SCIE 2020年第2期173-179,共7页
The paper aimed to study the flow structure at the wake of the bluff body with altered blockage ratio(BR)keeping the fixed aspect ratio(AR).The study was conducted by a finite volume technique using commercial softwar... The paper aimed to study the flow structure at the wake of the bluff body with altered blockage ratio(BR)keeping the fixed aspect ratio(AR).The study was conducted by a finite volume technique using commercial software Ansys-Fluent.The CFD analysis of the bluff body is mainly subjected to the lower subcritical Reynolds number range(5000 to 15,000)along with blockage ratio as an important factor.The flow parameters such as drag coefficient,pressure,and kinetic energy variations are analyzed here for the Reynolds number(Re)and BR.It was observed that at fixed Re,t he drag coefficient(CD)increases with an increase in the BR while decrease with increasing Re for a fixed value of BR. 展开更多
关键词 Blockage ratio Bluff body Drag coefficient Reynolds number
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