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Particle-size distribution and respiratory deposition of airborne pathogens and antimicrobial resistance risk determinants in wastewater treatment plants 认领 引用
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作者 Shanshan Gao Shaobin Li +4 位作者 Yajie Guo Qiaolin Xu Mo Chen Min Gao Xuming Wang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第8期752-762,共11页
Air in wastewater treatment plants(WWTPs)contains high concentrations of pathogens and antimicrobial resistance determinants(ARDs).However,limited information on their particle-size distribution hinders assessment of ... Air in wastewater treatment plants(WWTPs)contains high concentrations of pathogens and antimicrobial resistance determinants(ARDs).However,limited information on their particle-size distribution hinders assessment of occupational inhalation exposure risks in WWTPs.In this study,air samples above the aeration tanks and the secondary sedimentation tanks of WWTPs were collected using Anderson eight-stage air samplers,and the size-resolved bacterial community was characterized by 16S rRNA gene sequencing.The inhalation deposition of ARDs and pathogens in the human respiratory tract was quantitatively evaluated by droplet digital PCR.Results showed that airborne bacterial concentrations above the aeration tank increased with particle size,ranging from 2914 to 5645 copies/m3.By contrast,concentrations above the secondary sedimentation tank exhibited a bimodal distribution,with peaks at 5.8-9.0μm(5592 copies/m3)and 0.65-1.1μum(5302 copies/m3).The most prevalent airborne antibiotic resistance genes were tetW and floR,associated with aerodynamic diameters of 2.64μm and 3.43μm,respectively.The International Commission on Radiological Protection deposition model indicated that airborne pathogens and ARDs were primarily deposited in the upper respiratory tract(17.73-165.63 copies/h)and alveoli(1.84-14.63 copies/h).Notably,deposition densities of Escherichia coli and Enterococcus faecium reached 2.26-36.20 copies/hand 1.62-31.31 copies/h,respectively.Co-occurrence of these pathogens with floR and sulⅡin fine particulate matter may pose significant health risks.This study elucidates the size distribution and respiratory deposition behavior of ARDs and pathogens in WWTP air,addressing critical knowledge gaps for comprehensive assessment of airborne antimicrobial resistance and associated occupational health risks. 展开更多
关键词 Particle size distribution Respiratory deposition Antimicrobial resistance risk determinants(ARDs) Pathogen Wastewater treatment plants(WWTPs)
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Phage-Inspired Artificial Peroxidases with Robust Sub-Nanometer Cluster Sites for Efficient Oral Biofilm Elimination and Dental Caries Prevention 认领 引用
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作者 Huang Zhu Ting Wang +7 位作者 Shihuan Gao Wei Geng Tian Ma Liang Cheng Xianglong Han Jiuhong Deng Shanshan Gao Chong Cheng 《Nano-Micro Letters》 SCIE EI CAS CSCD 2026年第9期171-190,共20页
Dental caries,a highly prevalent oral disease,is primarily driven by pathogenic biofilms;however,current antimicrobials exhibit limited efficacy and poor specificity against cariogenic biofilms.Although nanobiocatalys... Dental caries,a highly prevalent oral disease,is primarily driven by pathogenic biofilms;however,current antimicrobials exhibit limited efficacy and poor specificity against cariogenic biofilms.Although nanobiocatalysts that can produce reactive oxygen species represent a promising alternative to conventional antimicrobials,most current designs fail to achieve robust bacterial interaction and exhibit insufficient disruption of biofilm integrity.To address these challenges,we report the de novo design of phage-inspired artificial peroxidases(IrNC@TiO2)featuring a robust sub-nanometer cluster site and urchin-like topography,which enables efficient oral biofilm elimination and dental caries prevention.Structural characterization confirmed that sub-nanometer Ir clusters are stably anchored to the TiO2support via Ir–O coordination.Leveraging the robust enzymatic activity of Ir clusterzymes and the topological advantages of the spiky substrate,IrNC@TiO2exhibits potent multi-enzyme mimetic activity,generating substantial amounts of·O2-and HClO to effectively capture and eradicate planktonic Streptococcus mutans and suppress biofilm formation.In a caries model,IrNC@TiO2significantly inhibited tooth surface biofilm development,prevented enamel demineralization,and reduced caries incidence.The material also demonstrated negligible cytotoxicity and outperformed conventional non-abrasive additives in tooth-whitening assays.This work introduces a robust and efficient ROS-generating platform for oral health care and proposes a promising solution for clinical caries prevention. 展开更多
关键词 Bioinspired design Artificial peroxidases ROS generation Biofilm eradication Dental caries
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Coupling coordination and control of water-polluting enterprises-water resources-water pollution systems in the Yellow River Basin 认领 引用
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作者 Peiyu Jia Jie Yang +5 位作者 Xiaoyu Ren Haibin Liang Ruidong Zhao Zongshan Li Lei Gong Shanshan Gao 《Ecological Frontiers》 CSCD 2025年第6期1572-1581,共10页
Water-polluting enterprises rely on water resources for production activities to bring economic benefits while generating large amounts of wastewater that pollute the water environment.Given the national strategy for ... Water-polluting enterprises rely on water resources for production activities to bring economic benefits while generating large amounts of wastewater that pollute the water environment.Given the national strategy for ecological protection and high-quality development of the Yellow River Basin,coordinating the relationships among water-polluting enterprises,water resources,and water pollution has become an important research topic for the sustainable development of the Yellow River Basin.Therefore,this paper clarified the spatial distribution characteristics of water-polluting enterprises and explored the coupling coordination relationship among water-polluting enterprises,water resources,and water pollution systems.Based on this,zonal control was implemented.The results proved that the water-polluting enterprises of the Yellow River Basin were agglomerated along the mainstream and primary tributaries.Spatially,they were centrally agglomerated in contiguous areas.Pollution discharge posed an ecological threat in this basin.Given the demand for economic growth and the current industrial layout,the Yellow River will continue to face enormous water pollution management pressures in the future.The development of water-polluting enterprises,water resources,and water pollution systems in this basin has formed the water pollution lagging type of coupling coordination.Thus,ecological threat reduction and water pollution management should be controlled according to the different regional conditions of the study area.Additionally,in this study,the interrelationships among the water-polluting enterprises,water resources,and water pollution systems have become increasingly close.The coupling coordination degree fluctuated but increased overall,indicating a continued growth trend in the future.While there were no signs that the growth trend has slowed in terms of the number,scale,and density of polluting enterprises in various cities.Therefore,the Yellow River Basin was finally divided into key control zones,optimized development zones,and priority protection zones,where zonal control should be implemented.The results are of great significance for the management of the water environment and the coordinated development of ecology and economy in the Yellow River Basin. 展开更多
关键词 Coupling coordination Spatial distribution characteristics Water-polluting enterprises Yellow River Basin Zonal control
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Minimal invasive microscopic tooth preparation in esthetic restoration: a specialist consensus 认领 引用 被引量：36
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作者 Haiyang Yu Yuwei Zhao +17 位作者 Junying Li Tian Luo Jing Gao Hongchen Liu Weicai Liu Feng Liu Ke Zhao Fei Liu Chufan Ma Juergen MSetz Shanshan Liang Lin Fan Shanshan Gao Zhuoli Zhu Jiefei Shen Jian Wang Zhimin Zhu Xuedong Zhou 《International Journal of Oral Science》 SCIE CAS CSCD 2019年第4期241-251,共11页
By removing a part of the structure,the tooth preparation provides restorative space,bonding surface,and finish line for various restorations on abutment.Preparation technique plays critical role in achieving the opti... By removing a part of the structure,the tooth preparation provides restorative space,bonding surface,and finish line for various restorations on abutment.Preparation technique plays critical role in achieving the optimal result of tooth preparation.With successful application of microscope in endodontics for>30 years,there is a full expectation of microscopic dentistry.However,as relatively little progress has been made in the application of microscopic dentistry in prosthodontics,the following assumptions have been proposed:Is it suitable to choose the tooth preparation technique under the naked eye in the microscopic vision?Is there a more accurate preparation technology intended for the microscope?To obtain long-term stable therapeutic effects,is it much easier to achieve maximum tooth preservation and retinal protection and maintain periodontal tissue and oral function health under microscopic vision?Whether the microscopic prosthodontics is a gimmick or a breakthrough in obtaining an ideal tooth preparation should be resolved in microscopic tooth preparation.This article attempts to illustrate the concept,core elements,and indications of microscopic minimally invasive tooth preparation,physiological basis of dental pulp,periodontium and functions involved in tool preparation,position ergonomics and visual basis for dentists,comparison of tooth preparation by naked eyes and a microscope,and comparison of different designs of microscopic minimally invasive tooth preparation techniques.Furthermore,a clinical protocol for microscopic minimally invasive tooth preparation based on target restorative space guide plate has been put forward and new insights on the quantity and shape of microscopic minimally invasive tooth preparation has been provided. 展开更多
关键词 preparation breakthrough removing
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Design and characterizing of robust probes for enhanced mass spectrometry imaging and spatially resolved metabolomics 认领 引用 被引量：4
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作者 Jianpeng Huang Shanshan Gao +4 位作者 Kai Wang Jin Zhang Xuechao Pang Junwen Shi Jiuming He 《Chinese Chemical Letters》 SCIE CAS CSCD 2023年第5期397-402,共6页
As for the emerging and cut edge spatially resolved metabolomics,mass spectrometry imaging(MSI)is a powerful tool that can map thousands of metabolites from bio-tissue sections without chemical labels.However,the stab... As for the emerging and cut edge spatially resolved metabolomics,mass spectrometry imaging(MSI)is a powerful tool that can map thousands of metabolites from bio-tissue sections without chemical labels.However,the stability,sensitivity and spatial resolution of MSI are always limited by the performance of its ionization probe.Herein,two types of probes(fine probe(P-100)and large probe(P-200))were designed and characterized to perform air-flow assisted desorption electrospray ionization(AFA-DESI)MSI analysis for spatially resolved metabolomics.It was determined that the spray introduced by P-100 was homogenous and stable under the spray solvent at a flow rate of 5-10μL/min,while P-200 can endure a high flow rate of up to 10-30μL/min.Moreover,the MSI images were acquired by AFA-DESI-MSI with P-100 from rat brain tissue section and with P-200 from whole-body tissue section of mouse,and these results presented unambiguous tissue structure with the distribution information of numerous metabolites.Furthermore,the spatially resolved metabolomic analysis of tumor tissue was successfully realized to discover the tumor associated biomarkers.As the key parts of AFA-DESI-MSI system,it has been demonstrated that the designed probs have excellent performance for spatially resolved metabolomics,and it will further promote its application in life science,and drug research and development. 展开更多
关键词 Air-flow assisted desorption electrospray ionization Mass spectrometry imaging Molecular imaging Spatially resolved metabolomics Brain
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Synthesis of Chitosan-Hydroxyapatite Composites and Its Effect on the Properties of Bioglass Bone Cement 认领 引用 被引量：3
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作者 Jingxiao Liu Fei Shi +2 位作者 Ling Yu Liting Niu Shanshan Gao 《Journal of Materials Science & Technology》 SCIE EI CAS 2009年第4期551-555,共5页
Chitosan-hydroxyapatite(CS-HA)composite powders were synthesized via in situ co-precipitation method,through the reaction of Ca(NO3)2 and H3PO4 in the simulated body fluid(SBF)containing appropri-ate amount of chitosa... Chitosan-hydroxyapatite(CS-HA)composite powders were synthesized via in situ co-precipitation method,through the reaction of Ca(NO3)2 and H3PO4 in the simulated body fluid(SBF)containing appropri-ate amount of chitosan.The thermal evolution,microstructure and morphology were studied by TG-DTA(thermogravimetry-differential thermal analysis),XRD(X-ray diffraction),FTIR(Fourier transform infrared spectroscopy)and TEM(transmission electron microscopy).The in vitro bioactivity test showed that the obtained CS-HA composites had higher capability of inducing calcium ions deposition.Effects of CS-HA com-posites on the bioactivity and compressive strength of bioglass bone cement were investigated.The results indicated that the bioactivity of bioglass bone cement could be improved further when CS-HA composite pow-ders were added into the cement,and appropriate amount of CS-HA additive was favorable for compressive strength improvement of bioglass bone cement. 展开更多
关键词 Hydroxyapatite Chitosan Composites Bone cement
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Tumor Necrosis Factor a Reduces SNAP29 Dependent Autolysosome Formation to Increase Prion Protein Level and Promote Tumor Cell Migration 认领 引用 被引量：1
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作者 Huan Li Ren Wang +9 位作者 Ze Yu Run Shi Jie Zhang Shanshan Gao Ming Shao Shuzhong Cui Zhenxing Gao Jiang Xu Man-Sun Sy Chaoyang Li 《Virologica Sinica》 SCIE CAS CSCD 2021年第3期458-475,共18页
Tumor Necrosis Factor α(TNFα) is best known as a mediator of inflammation and immunity, and also plays important roles in tumor biology. However, the role of TNFα in tumor biology is complex and not completely unde... Tumor Necrosis Factor α(TNFα) is best known as a mediator of inflammation and immunity, and also plays important roles in tumor biology. However, the role of TNFα in tumor biology is complex and not completely understood. In a human melanoma cell line, M2, and a lung carcinoma cell line, A549, TNFα up-regulates prion protein(PrP) level, and promotes tumor cell migration in a PrP dependent manner. Silencing PRNP abrogates TNFα induced tumor cell migration;this phenotype is reversed when PRNP is re-introduced. Treatment with TNFα activates nuclear factor kappa B(NF-κB)signaling, which then mitigates autophagy by reducing the expression of Forkhead Box P3(FOXP3). Down regulation of FOXP3 reduces the transcription of synaptosome associated protein 29(SNAP29), which is essential in the fusion of autophagosome and lysosome creating autolysosome. FOXP3 being a bona fide transcription factor for SNAP29 is confirmed in a promoter binding assay. Accordingly, silencing SNAP29 in these cell lines also up-regulates PrP, and promotes tumor cell migration without TNFα treatment. But, when SNAP29 or FOXP3 is silenced in these cells, they are no longer respond to TNFα. Thus, a reduction in autophagy is the underlying mechanism by which expression of PrP is up-regulated,and tumor cell migration is enhanced upon TNFα treatment. Disrupting the TNFα-NF-κB-FOXP3-SNAP29 signaling axis may provide a therapeutic approach to mitigate tumor cell migration. 展开更多
关键词 Tumor necrosis factorα(TNFα) Prion protein Synaptosome associated protein 29(SNAP29) Autophagy Nuclear factor kappa B(NF-κB) Forkhead box P3(FOXP3)
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Influence of transition metals(Sc,Ti,V,Cr,and Mn)doping on magnetism of CdS 认领 引用
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作者 Zhongqiang Suo Jianfeng Dai +1 位作者 Shanshan Gao Haoran Gao 《Chinese Physics B》 SCIE EI CAS CSCD 2020年第11期485-491,共7页
The influence of transition metals(Sc,Ti,V,Cr,and Mn)doping at different distances on the magnetism of CdS is studied by using generalized gradient approximation combined with Hubbard U in the VASP package.The results... The influence of transition metals(Sc,Ti,V,Cr,and Mn)doping at different distances on the magnetism of CdS is studied by using generalized gradient approximation combined with Hubbard U in the VASP package.The results show that the doping systems are more stable,easy to form,and the wurtzite structure of CdS is not changed.It is found that the systems are antiferromagnetic(AFM)when nearest neighbor doping,which is attributed to the direct charge transfers between two impurity ions.The systems are ferromagnetic(FM)when the doping distance increases further,since the double exchange interactions are observed among the 3d orbital of the transition metal,the Cd-5s and the S-3p orbitals are at conduction band minimum.We also found that the total magnetic moment of each ferromagnetic system increases with the order of SC to Mn-doping,the spin polarizability of Cr-doping system is 100%.The estimated Curie temperature indicates that the Cr-and Mn-doped CdS in this paper can achieve room-temperature ferromagnetic characteristics,especially the Cr doping is the most prominent.And TM-doping does not destroy the semiconductor characteristics of the system.Therefore,the TM-doped CdS can be used as an ideal dilute magnetic semiconductor functional material. 展开更多
关键词 transition metals doping electronic structure magnetism CdS Curie temperature
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Binding between Prion Protein and Aβ Oligomers Contributes to the Pathogenesis of Alzheimer’s Disease 认领 引用 被引量：5
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作者 Chang Kong Hao Xie +7 位作者 Zhenxing Gao Ming Shao Huan Li Run Shi Lili Cai Shanshan Gao Taolei Sun Chaoyang Li 《Virologica Sinica》 SCIE CAS CSCD 2019年第5期475-488,共14页
A plethora of evidence suggests that protein misfolding and aggregation are underlying mechanisms of various neurodegenerative diseases,such as prion diseases and Alzheimer's disease(AD).Like prion diseases,AD has... A plethora of evidence suggests that protein misfolding and aggregation are underlying mechanisms of various neurodegenerative diseases,such as prion diseases and Alzheimer's disease(AD).Like prion diseases,AD has been considered as an infectious disease in the past decades as it shows strain specificity and transmission potential.Although it remains elusive how protein aggregation leads to AD,it is becoming clear that cellular prion protein(PrP^c)plays an important role in AD pathogenesis.Here,we briefly reviewed AD pathogenesis and focused on recent progresses how PrP^c contributed to AD development.In addition,we proposed a potential mechanism to explain why infectious agents,such as viruses,conduce AD pathogenesis.Microbe infections cause AD deposition and upregulation of PrP^c,which lead to high affinity binding between AD oligomers and PrP^c.The interaction between PrP^c and AP oligomers in turn activates the Fyn signaling cascade,resulting in neuron death in the central nervous system(CNS).Thus,silencing PrP^c expression may turn out be an effective treatment for PrP^c dependent AD. 展开更多
关键词 Alzheimer’s disease(AD) Amyloid-βprotein Neurodegenerative disease Cellular prion protein(PrP^c)
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Percutaneous microwave ablation combined with simultaneous transarterial chemoembolization for hepatocellular carcinoma with macrovascular invasion or extrahepatic metastases 认领 引用 被引量：4
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作者 Mengfei Wu Shanshan Gao +6 位作者 Huadan Song Zihan Zhang Zhiyuan Zheng Zhiping Yan Xiaolin Wang Jianhua Wang Lingxiao Liu 《Journal of Interventional Medicine》 2019年第2期55-59,共5页
Objective:To evaluate the safety and efficacy of percutaneous microwave ablation(MWA)combined with simultaneous transarterial chemoembolization(TACE)in patients with hepatocellular carcinoma(HCC)patients with microvas... Objective:To evaluate the safety and efficacy of percutaneous microwave ablation(MWA)combined with simultaneous transarterial chemoembolization(TACE)in patients with hepatocellular carcinoma(HCC)patients with microvascular invasion(MVI)or extrahepatic metastases(EHM).Methods:Between August 2012 and April 2017,101 patients with MVI/EHM of HCC underwent percutaneous MWA combined with simultaneous TACE at our center.The clinical data were collected and analyzed for survival and prognostic factors.Results:The mean follow-up time was 23.6±14.7 months.One patient had grade 3 complications,and the median overall survival was 12.0 months(95%confidence interval 9.7-14.3).Multivariate analysis showed that ChildPugh class,serum alpha-fetoprotein level,and Eastern Cooperative Oncology Group performance status were independent factors of survival.Conclusion:Our results suggest that percutaneous MWA combined with simultaneous TACE is a safe and effective treatment for HCC with MVI/EHM. 展开更多
关键词 Hepatocellular carcinoma Combination therapy Microwave ablation Survival
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Hepatitis C virus-induced prion protein expression facilitates hepatitis C virus replication 认领 引用 被引量：2
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作者 Huixia Zhang Shanshan Gao +2 位作者 Rongjuan Pei Xinwen Chen Chaoyang Li 《Virologica Sinica》 SCIE CAS CSCD 2017年第6期503-510,共8页
Hepatitis C virus(HCV) infects approximately 180 million people worldwide. Significant progress has been made since the establishment of in vitro HCV infection models in cells. However, the replication of HCV is compl... Hepatitis C virus(HCV) infects approximately 180 million people worldwide. Significant progress has been made since the establishment of in vitro HCV infection models in cells. However, the replication of HCV is complex and not completely understood. Here, we found that the expression of host prion protein(Pr P) was induced in an HCV replication cell model. We then showed that increased Pr P expression facilitated HCV genomic replication. Finally, we demonstrated that the KKRPK motif on the N-terminus of Pr P bound nucleic acids and facilitated HCV genomic replication. Our results provided important insights into how viruses may harness cellular protein to achieve propagation. 展开更多
关键词 hepatitis C virus(HCV) NS3 NS5B prion protein(PrP)
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Preparation and Adsorption Properties of Biomass Activated Carbon from Ginger Stems 认领 引用 被引量：3
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作者 Jinling Liu Xiaoming Song +1 位作者 Shanshan Gao Fushan Chen 《Paper And Biomaterials》 CAS 2019年第4期45-50,共6页
Biomass activated carbon(BAC)was produced from ginger stems by carbonization and activation presented high specific surface areas and mesoporous structures.The carbonization temperature of the ginger stems were contro... Biomass activated carbon(BAC)was produced from ginger stems by carbonization and activation presented high specific surface areas and mesoporous structures.The carbonization temperature of the ginger stems were controlled within 500~900℃.The optimal carbonization condition is as follows:carbonization temperature of 700℃,carbonization time of 6 h.The determined optimum activation condition is:temperature of 800℃,activator of KOH and carbonized product/alkali ratio of 1:4(w/w).The carbonization yield,BAC yield and Brunauer-Emmett-Teller(BET)surface area were measured and the adsorption performance of BAC to nitrogen was investigated.The results showed that the nitrogen adsorption isotherm curve was as type I isotherm.It was finally determined that the BET surface area was 660 m2/g under the abovementioned optimal conditions of carbonization and activation.The FESEM analysis indicates that the obtained BAC is of micropore structure. 展开更多
关键词 ginger stems biomass activated carbon carbonization activation
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Heterogeneous Reactions between Starch and AKD under Solvent-free Conditions 认领 引用 被引量：1
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作者 ShanShan Gao XiaoMing Song +3 位作者 FuShan Chen LianQing Huang JunXun Li SongLin Wang 《Paper And Biomaterials》 CAS 2016年第2期27-31,共5页
Oxidized starch powder and cationic starch solution were reacted with alkyl ketene dimer(AKD) under heterogeneous conditions at 70℃ for 12 h.The AKD molecules reacted with starch hydroxyl groups to form β-keto ester... Oxidized starch powder and cationic starch solution were reacted with alkyl ketene dimer(AKD) under heterogeneous conditions at 70℃ for 12 h.The AKD molecules reacted with starch hydroxyl groups to form β-keto ester linkages under the above conditions.The reaction products were separated into CHCl_3-soluble and CHCl_3-insoluble fractions.FT-IR spectroscopy,SEM,Xray diffraction,and TG-DTA analyses of the CHCl_3-insoluble fraction indicated that β-keto ester substituents were introduced to hydroxyl groups on the starch surfaces.The results indicated that hydrogen bonds between the starch molecules were disrupted under heterogeneous conditions upon heating.The activity and accessibility of hydroxyl groups were enhanced,as a result of which β-keto ester bonds were produced between AKD and starch.Based on these results,we speculate that the β-keto esters which existed in the sheets sized by AKD emulsions were generated by the reaction between AKD and starch. 展开更多
关键词 AKD cationic starch oxidized starch heterogeneous reaction sizing agent
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Green Superhydrophobic Paper with Self-cleaning Properties Prepared via One-step Impregnation 认领 引用
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作者 Xiangbin Zhang Shanshan Gao +4 位作者 Xiaoming Song Jiale Wang Xunqian Wu Fushan Chen Shiyuan Xie 《Paper And Biomaterials》 CAS 2023年第4期9-19,共11页
In this study,a green and pollution-free multifunctional superhydrophobic paper-based material was prepared using a simple and efficient dipping method.The superhydrophobic paper with a water contact angle(WCA)of 160&... In this study,a green and pollution-free multifunctional superhydrophobic paper-based material was prepared using a simple and efficient dipping method.The superhydrophobic paper with a water contact angle(WCA)of 160°was prepared by attaching micro-and nanocomposite particles,made of stearic acid-modified chitosan and two kinds of titanium dioxide(TiO2)nanoparticles of different sizes,to a paper substrate.The surface morphology,elemental composition,and wetting properties of the coatings were examined using scanning electron microscopy(SEM),X-ray photoelectron spectroscopy(XPS),Fourier transform infrared spectroscopy(FT-IR),and contact angle measurements.Additionally,superhydrophobic coatings exhibited good self-cleaning properties,liquid repellency,ease of repair,and antifouling properties in organic solutions. 展开更多
关键词 superhydrophobic impregnation green paper-based self-cleaning
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Understanding the changes in multi-structure,physicochemical properties,and in vitro digestibility of quinoa starch by annealing with hydrogen-infused and plasma-activated water samples 认领 引用 被引量：1
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作者 Hang Liu Ge Tian +1 位作者 Shanshan Gao Shuang Liu 《Journal of Future Foods》 CAS CSCD 2026年第2期292-300,共9页
We studied the combination effects of annealing(aNN)and distilled,hydrogen-infused,and plasmaactivated waters on the multi-structure,physicochemical properties,and in vitro digestibility of quinoa starch(QS).to the be... We studied the combination effects of annealing(aNN)and distilled,hydrogen-infused,and plasmaactivated waters on the multi-structure,physicochemical properties,and in vitro digestibility of quinoa starch(QS).to the best of our knowledge,hydrogen-infused water was used to modify starch for the first time.Compared to that of native QS,aNN-modified samples had rougher surfaces and retained the a type X-ray diffraction pattern but with higher relative crystallinity.aNN treatment significantly increased amylose content,gelatinization properties,and water absorption capacity of QS,while the swelling power and viscosity decreased.the total hydrolysis rate and rapidly digestive starch content decreased in QS after aNN treatment,and resistant starch level markedly increased.Compared to aNN with distilled water,the combination of aNN with hydrogen-infused and plasma-activated waters exhibited a higher extent of influence on the properties of QS.the sample treated with plasma-activated water showed the highest extent,which was potentially attributed to the acidic environment and the presence of reactive oxygen and nitrogen species.this research provided a novel strategy to further improve the thermal stability and functionality of starch. 展开更多
关键词 Quinoa starch annealing treatment Plasma-actived water Hydrogen-infused water Multi-structures Digestibility
耳甲电针(taVNS)治疗轻度认知障碍研究进展 认领 引用 被引量：2
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作者 陈庆燕 高山山 +3 位作者 郭春蕾 闫华 杨戈 方继良 《阿尔茨海默病及相关病杂志》 2024年第2期142-146,共5页
轻度认知障碍的治疗是老年健康需要解决的难题。基于中医“脑病耳治”理论的新型神经调控技术——耳甲电针(taVNS),可辅助治疗多种神经、精神系统疾病,近年研究发现其对轻度认知障碍有效。对目前国内外耳甲电针治疗轻度认知障碍的研究... 轻度认知障碍的治疗是老年健康需要解决的难题。基于中医“脑病耳治”理论的新型神经调控技术——耳甲电针(taVNS),可辅助治疗多种神经、精神系统疾病,近年研究发现其对轻度认知障碍有效。对目前国内外耳甲电针治疗轻度认知障碍的研究现状进行综述,探讨其疗效、机制,展示其研究成果,提出进一步研究方向。将为MCI非药物疗法提供可借鉴的新思路,为广大老年患者的认知功能改善和生活品质提高提供新技术。 展开更多
关键词 轻度认知障碍 耳甲电针 经皮耳穴迷走神经刺激术 神经调控 研究进展
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即刻耳甲电针刺激对轻度认知障碍脑功能影像的影响初探 认领 引用 被引量：1
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作者 郭春蕾 马跃 +3 位作者 高山山 罗屹 陈庆燕 方继良 《阿尔茨海默病及相关病杂志》 2024年第2期94-102,81,共9页
目的:基于静息态功能磁共振成像(rs-fMRI)探讨即刻(30分钟)耳甲电针(taVNS)刺激对轻度认知障碍(MCI)患者脑功能的影响。方法:纳入22例MCI患者,随机分为taVNS组和sham taVNS组,每组各11例,同时纳入11例健康对照(HCs)。3组受试者均进行30... 目的:基于静息态功能磁共振成像(rs-fMRI)探讨即刻(30分钟)耳甲电针(taVNS)刺激对轻度认知障碍(MCI)患者脑功能的影响。方法:纳入22例MCI患者,随机分为taVNS组和sham taVNS组,每组各11例,同时纳入11例健康对照(HCs)。3组受试者均进行30分钟耳部电针刺激,其中taVNS组和HCs组接受耳甲刺激位于迷走神经主要分布区,sham taVNS组接受的刺激位于非迷走神经分布的耳舟部,在刺激前后各进行一次rs-fMRI扫描。采用DPABI 8.0软件对rs-fMRI扫描结果进行预处理,随后计算功能连接(FC),对3组受试者刺激前后的FC图像进行比较,并将结果提值,用Graphpad Prism9.0.0进行事后分析,观察taVNS对脑功能的影响。结果:与刺激前相比,刺激后taVNS组右侧海马与右侧小脑_6的FC值显著降低(P<0.005)、左侧尾状核与右侧额上回以及右侧苍白球与左侧尾状核的FC值显著升高(P<0.05);刺激后HCs组左侧尾状核与小脑_8的FC值显著降低(P<0.05)。结论:即刻taVNS可以调节记忆及认知脑区,以及基底节区及小脑等脑功能网络,可能是taVNS治疗MCI的效应靶点。 展开更多
关键词 轻度认知障碍 耳甲电针 静息态功能磁共振成像 功能连接
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Bag-controlled low-nitrogen fertilization induces root arbutin secretion to enrich rhizosphere Pseudomonas and enhance nitrogen fixation in peach 认领 引用
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作者 Yanyan Li Jian Guo +8 位作者 Huitian Wei Guangyuan Liu Shanshan Gao Zixuan Li Zhe Wang Xiaoyue Zhang Qiuju Chen Yuansong Xiao Futian Peng 《Plant Communications》 SCIE CSCD 2026年第7期149-163,共15页
Interactions between plant roots and nitrogen(N)-fixing microorganisms in the rhizosphere are crucial for plant growth and development.However,the contribution of rhizosphere microbial N fixation to peach tree growth ... Interactions between plant roots and nitrogen(N)-fixing microorganisms in the rhizosphere are crucial for plant growth and development.However,the contribution of rhizosphere microbial N fixation to peach tree growth and the underlying interaction mechanisms remain unclear.Our study demonstrated that peach trees under bag-controlled,precise,and stabilized low-N(BCLN)fertilization exhibited significantly increased root microbial abundance and soil N fixation.The peach rhizosphere soil showed significantly enhanced microbialα-diversity,increased abundance of N-fixing microbes,and elevated nitrogenase ac-tivity under BCLN fertilization.Further analysis indicated that BCLN fertilization induced peach roots to secrete arbutin,which mediated enrichment of the Pseudomonas strain DT33X,an N-fixing bacterium,thereby enhancing plant N-use efficiency(i.e.,N accumulation relative to input).Arbutin,a component of root exudates,enhanced the growth,colonization,and N-fixation capacity of DT33X,as evidenced by an increased nifH gene copy number in soil.Together,these findings elucidate a mechanistic link between peach roots and N-fixing microbes under BCLN fertilization,demonstrating that specific root-derived signaling molecules can modulate N-fixing bacteria,thereby improving N-use efficiency in peach trees. 展开更多
关键词 BCLN fertilization rhizosphere nitrogen-fixing microbiota Pseudomonas arbutin peach
帕金森病相关认知障碍的神经影像学特征研究进展 认领 引用 被引量：1
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作者 高山山 马跃 +3 位作者 郭春蕾 罗屹 陈庆燕 方继良 《阿尔茨海默病及相关病杂志》 2024年第4期312-316,共5页
认知障碍作为最易致残的帕金森病非运动症状之一,严重影响患者的生活质量,故应引起重视。神经影像学作为客观指标,可以帮助临床医生和研究者尽早发现帕金森相关认知障碍的发生。现从帕金森-主观认知能力下降(PD-SCD)、帕金森-轻度认知障... 认知障碍作为最易致残的帕金森病非运动症状之一,严重影响患者的生活质量,故应引起重视。神经影像学作为客观指标,可以帮助临床医生和研究者尽早发现帕金森相关认知障碍的发生。现从帕金森-主观认知能力下降(PD-SCD)、帕金森-轻度认知障碍(PD-MCI)、帕金森痴呆(PD-D)三个方面,综述对此类疾病的神经影像学研究进展。检索后发现,PDSCD诊断标准不明确,但少量研究报道其存在广泛大脑皮层活动和深部白质改变;PD-MCI除明确与帕金森多巴胺系统功能相关,其白质改变已涉及海马等记忆相关结构;PD-D在PD-MCI的基础上白质病变进一步加深,灰质萎缩明显,脑网络功能受累范围进一步扩大,包含基础感知系统障碍。 展开更多
关键词 帕金森病 认知障碍 神经影像学
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1-MHz High-step-up Converter with Switched Inductors Based on Optimized Integrated Magnetics 认领 引用
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作者 Shanshan Gao Xikun Sang +3 位作者 Yijie Wang Houkun Song Dianguo Xu JoséMarcos Alonso 《CSEE Journal of Power and Energy Systems》 SCIE EI CSCD 2026年第3期1587-1597,共11页
A 1-MHz single-switch high-step-up converter with switched inductors is proposed,suitable for high-voltage applications.On the basis of a conventional single-ended primary inductor converter(SEPIC),a switched inductor... A 1-MHz single-switch high-step-up converter with switched inductors is proposed,suitable for high-voltage applications.On the basis of a conventional single-ended primary inductor converter(SEPIC),a switched inductor cell with a pump capacitor and a voltage multiplier unit is added to achieve high voltage gain.The proposed converter works in discontinuous conduction mode(DCM)to realize soft switching.In addition,the switch adopts wide-bandgap semiconductor gallium nitride(GaN)to obtain better high-frequency performance.To further increase efficiency,magnetic integration technology is used to achieve structural integration of the three inductors.An optimized scheme based on a commercial core is determined according to simulation and calculation results.Operational principles and parameter design process are introduced in detail in this paper.A 1-MHz,200-W prototype operating in DCM with a voltage gain exceeding 13 times has been designed to verify the theoretical analysis.Measured efficiency reaches up to 94.3%at full load. 展开更多
关键词 High voltage gain integrated magnetics soft switching switched inductor
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