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Measuring ice lens initiation in soils by particle image velocimetry 认领 引用 被引量：1
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作者 Jinfeng Li Jidong Teng +3 位作者 Haosong He Wenzhang Xu Jenisha Singh Sheng Zhang 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2026年第1期761-771,共11页
Ice lens initiation is the core issue in understanding the dynamic process of frost heave.However,there are still limitations to find an adequate criterion for describing the formation of ice lens.A series of one-dime... Ice lens initiation is the core issue in understanding the dynamic process of frost heave.However,there are still limitations to find an adequate criterion for describing the formation of ice lens.A series of one-dimensional freezing tests is designed using the particle image velocimetry(PIV)method to monitor the frost heave and ice lens formation.The results show that the conventional parameters,such as displacement and velocity,cannot be used to track the ice lens formation,while the strain can be employed to detect the ice lens formation and investigate the freezing change patterns.This study proposes strain as a new criterion for assessing ice lens initiation,applicable across various soil types and freezing conditions(constant freezing and ramped freezing).The strain change in the region where the ice lens forms is the largest during the freezing process.Additionally,strain curves at the top of the soil samples can reveal different freezing patterns and distinguish the first and second frost heave stages.This newly developed technology enables continuous,non-destructive monitoring of ice lens initiation across diverse conditions and soil types,enhancing data visualization and three-dimensional modeling of freezing parameters while improving traditional methods by directly measuring velocity and strain in frost heave investigations.The study is expected to enhance the research of ice lens criterion and provide a new perspective for monitoring the freezing process. 展开更多
关键词 Frost heave Ice lens initiation Particle image velocimetry(PIV) Strain
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ZmCals12 impacts maize growth and development by regulating symplastic transport 认领 引用
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作者 Ziwen Shi Sheng Zhang +6 位作者 Qing He Xiaoyuan Wang Bo Yang Tao Yu Hongyang Yi Tingzhao Rong Moju Cao 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第1期42-55,共14页
Carbohydrate partitioning from source to sink tissues is essential for plant growth and development.However,in maize(Zea mays L.),the molecular mechanisms by which callose synthase genes regulate this process remain l... Carbohydrate partitioning from source to sink tissues is essential for plant growth and development.However,in maize(Zea mays L.),the molecular mechanisms by which callose synthase genes regulate this process remain largely unexplored.This study demonstrates that mutation of maize callose synthase12(Zm Cals12)results in increased carbohydrate accumulation in photosynthetic leaves but decreased carbohydrate content in sink tissues,leading to plant dwarfing and male sterility.Histochemical β-glucuronidase(GUS)activity assay and m RNA in situ hybridization(ISH)revealed that Zm Cals12 expression mainly occurs in the vascular transport system.Zm Cals12 loss-of-function decreased callose synthase activity and callose deposition in plasmodesmatas(PDs)and surrounding phloem cells(PCs)of the vascular bundle.The drop-and-see(DANS)assay indicated reduced PD permeability in photosynthetic cells and diminished transport competence of leaf veins in Zmcals12 mutants,resulting in decreased symplastic transport.Paraffin section analysis revealed that less-developed vascular cells(VCs)in Zmcals12 mutants likely disrupted sugar transport,contributing to the pleiotropic phenotype.Furthermore,impaired sugar transport inhibited internode development by suppressing auxin(IAA)biosynthesis and signaling in Zmcals12 mutant.These findings elucidate the mechanism by which Zm Cals12-mediated callose deposition and symplastic transport regulate maize growth and development. 展开更多
关键词 maize ZmCals12 plasmodesmata(PD)permeability symplastic transport less-developed vascular cells(VCs) auxin(IAA)biosynthesis and signaling
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Estimation of Peierls-Nabarro stress of dislocations by the first-principles calculation in Mg alloys and their effects on plasticity 认领 引用
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作者 Mingdi Yu Jingya Wang +7 位作者 Zhigang Ding Bo Hu Hongwei Xiong Sheng Zhang Zhenfei Jiang Zhihua Dong Tao Ying Xiaoqin Zeng 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2026年第4期143-159,共17页
Poor plasticity is an intrinsic disadvantage of magnesium(Mg)alloys,which limits their wide application at room temperature.Alloying is an accepted method to tune the plastic deformation mode and improve plasticity.Ho... Poor plasticity is an intrinsic disadvantage of magnesium(Mg)alloys,which limits their wide application at room temperature.Alloying is an accepted method to tune the plastic deformation mode and improve plasticity.However,the effect of solute atoms on the activation of different dislocations is still unclear and has rarely been systematically investigated in Mg alloys.In this work,the formulations of Peierls-Nabarro stresses(σp)for edge and screw dislocations along various slip planes in Mg-X(X=Y,Ca,Nd,Zn,Al and Sn)alloys are firstly derivate,as well as the calculation of the parameter K(energy factor)based on the first-principles calculation.The effects of solute atoms on the σp of various types of dislocations are systematically studied.The difference of the σp between the Mg-X alloy and pure Mg,i.e.,△σp,is determined,which is strongly influenced by the solute atoms.The negative △σp reflects the promotion of dislocation activation.The relationship between the △σp of different non-basal dislocations and elongation in eight Mg-X alloys is explored.The simultaneous improvement of the activation of the prismaticand the pyramidaldislocations is discovered,which can be achieved by specific alloying elements.Cooperative activation of the prismaticand the pyramidaldislocations owing to the reduced △σp is shown to closely correlate with the significant increased plasticity of the Mg alloys.These findings advance a novel perspective on alloy design strategies for Mg alloys with improved plasticity. 展开更多
关键词 Mg alloys Peierls-Nabarro stress First-principles calculation Non-basal slip activity Generalized stacking fault energy
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A Bayesian-based framework for quantifying model-inherent uncertainties in soil constitutive models 认领 引用
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作者 Haibin Xiong Shaoheng Dai +3 位作者 Feng Shan Xuzhen He Sheng Zhang Daichao Sheng 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2026年第6期4867-4881,共15页
Quantifying uncertainty in soil constitutive models is both challenging and essential for improving predictive reliability.While the Bayesian approach offers an effective framework for this purpose,previous studies ha... Quantifying uncertainty in soil constitutive models is both challenging and essential for improving predictive reliability.While the Bayesian approach offers an effective framework for this purpose,previous studies have primarily focused on uncertainties in input parameters of standard“ideal”constitutive models.However,models such as the Mohr-Coulomb,Cam-Clay,and Modified Cam-Clay are based on simplified assumptions that do not fully capture real soil behaviour,making it impossible for them to match real-world data perfectly.This study introduces a novel Bayesian-based framework that transforms deterministic models into probabilistic ones,allowing for the quantification of model-inherent uncertainty.A modified maximum a posteriori(MAP)estimator is employed,incorporating a penalty term into the negative log-likelihood to form a new loss function,which enhances bias estimates and model reliability.Using this method,three assumptions about the model bias term are evaluated against triaxial test data from Karlsruhe sand and White clay.The results demonstrate that non-constant assumptions about the bias term significantly enhance model performance.Among the models tested,the probabilistic Modified Cam-Clay model with a nonlinear bias assumption exhibits the best performance.Conversely,the probabilistic Mohr-Coulomb model reveals certain limitations,including overpredicted peak deviatoric stress and overfitted volumetric strain,underscoring the need for further refinements. 展开更多
关键词 Uncertainty quantification Maximum a posteriori(MAP) Probabilistic models Model bias Constitutive models
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Compact formulation of the augmented evolution equation for optimal control computation 认领 引用
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作者 Sheng Zhang Jiangtao Huang +2 位作者 Gang Liu Fei Liao Fangfang Hu 《Control Theory and Technology》 EI CSCD 2026年第1期96-110,共15页
The augmented evolution equation is established under the framework of the Variation Evolving Method(VEM)that seeks optimal solutions by solving the transformed Initial-Value Problems(IVPs).To improve the numerical pe... The augmented evolution equation is established under the framework of the Variation Evolving Method(VEM)that seeks optimal solutions by solving the transformed Initial-Value Problems(IVPs).To improve the numerical performance,its compact form is developed herein.Through replacing the states and costates variation evolution with that of the controls,the dimension-reduced Evolution Partial Differential Equation(EPDE)only solves the control variables along the variation time to get the optimal solution,and the initial conditions for the definite solution may be arbitrary.With this equation,the scale of the resulting IVPs,obtained via the semi-discrete method,is significantly reduced and they may be solved with common Ordinary Differential Equation(ODE)integration methods conveniently.Meanwhile,the state and the costate dynamics share consistent stability in the numerical computation and this avoids the intrinsic numerical difficulty as in the indirect methods.Numerical examples are solved and it is shown that the compact form evolution equation outperforms the primary form in the precision,and the efficiency may be higher for the dense discretization.Actually,it is uncovered that the compact form of the augmented evolution equation is a continuous realization of the Newton type iteration mechanism. 展开更多
关键词 Optimal control Lyapunov dynamics stability Variation evolution Evolution partial differential equation Initial-value problem
Fluoride-induced sign inversion of circularly polarized luminescence of B,N-thia[8]helicene 认领 引用
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作者 Shuai Qiu Jia Tang +6 位作者 Wan Xu Zhiying Ma Chao Zhang Sheng Zhang Chunli Li Wei Tian Hua Wang 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第6期551-554,共4页
A novel thia[8]helicene(BN[8]H)withB,N heteroatoms incorporated in the molecular skeleton was synthesized via Suzuki coupling reaction and intramolecular direct electrophilic C-H borylation.Its helical structure was c... A novel thia[8]helicene(BN[8]H)withB,N heteroatoms incorporated in the molecular skeleton was synthesized via Suzuki coupling reaction and intramolecular direct electrophilic C-H borylation.Its helical structure was confirmed by X-ray crystal analysis.Enantiomers BN[8]H showed the interesting responses to fluoride ion stimulation with novel sign inversion of electronic circular dichroism(ECD)and circularly polarized luminescence(CPL).TD-DFT calculations revealed that the fluoride ions significant influence the transition dipole moments andθu,m,resulting in circularly polarized luminescence reversal. 展开更多
关键词 Helicene Circularly polarized luminescence Sign inversion Fluoride ions
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Robust Multitask Diffusion Bias-Compensated LMS Algorithm for Distributed Estimation with Noisy Link and Input 认领 引用
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作者 Xuzhao Chai Linru Zhang +2 位作者 Pengwei Wen Sheng Zhang Haiquan Zhao 《Journal of Beijing Institute of Technology》 EI CAS 2026年第2期137-149,共13页
This paper presents a robust multitask diffusion average bias compensation least mean square(RM-DABC-LMS)algorithm for distributed estimation in noisy input and communication link noise.The algorithm utilizes a robust... This paper presents a robust multitask diffusion average bias compensation least mean square(RM-DABC-LMS)algorithm for distributed estimation in noisy input and communication link noise.The algorithm utilizes a robust cost function based on the maximum Versoria criterion,incorporates bias compensation,and applies adaptive combination coefficients to reduce noise impacts.Theoretical analysis demonstrates the stability of the algorithm,providing closed-form expressions for the steady-state mean square deviation(MSD).A compression diffusion strategy is introduced to reduce communication cost of the RM-DABC-LMS algorithm,ensuring fast convergence and accurate estimation.Simulation results indicate that the proposed algorithm outperforms existing methods in noisy environments,achieving faster convergence and lower steady-state error. 展开更多
关键词 multitask networks robust bias compensation average estimate
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Advancing Automated Liquid-Handling Systems:Development and Evaluation of a Nonlinear Error-Compensated Air-Displacement Pipettor 认领 引用
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作者 Jun Lu Zhizhong Zhang +13 位作者 Qingqing Ye Sheng Zhang Jianqiang Chen Yuanhua Wang Guodong Sun Zhiyong Sun Jisheng Qin Jianhua Dong Shiwen Mai Fengxiang Zhang Xiaohui Wen Xiao Zhang Guanglei Zhao Xueping Chen 《Instrumentation》 2026年第1期57-74,共18页
This study introduces a nonlinear error-compensated air-displacement pipettor(NEC_ADP),a novel system that addresses the key limitations in commercial pipetting setups.By incorporating nonlinear error-compensation(NEC... This study introduces a nonlinear error-compensated air-displacement pipettor(NEC_ADP),a novel system that addresses the key limitations in commercial pipetting setups.By incorporating nonlinear error-compensation(NEC)technology,the NEC_ADP improves the accuracy and precision of liquid handling across a wide range of volumes,from micro-volumes(1μL)to macro-volumes(up to 1000μL),and for reagents with varying viscosities and surface tensions.Unlike conventional pipettors,which rely on linear compensation or manual recalibration,NEC_ADP features real-time,online calibration,eliminating the need for factory recalibration and reducing maintenance costs.The system was built with a modular design,allowing seamless scalability from single-to multi-channel configurations.It integrates effortlessly with existing laboratory systems using the open platform communications unified architecture(OPC UA),enhancing interoperability and automation.In addition,the use of machine-learning algorithms for motion control and trajectory planning ensures optimal pipetting strategies and automatic adaptation to different reagents and volumes.This study demonstrates the superior performance of NEC_ADP compared to commercial systems,including the TECAN Cavro®and Eppendorf epMotion®,with significant improvements in accuracy and precision.Innovation in NEC_ADP technology and system integration marks a significant advancement in automated liquid handling,offering robust support for highprecision applications in fields such as genomics,stemcell research,and synthetic biology. 展开更多
关键词 nonlinear error compensated air displacement pipettor(NEC_ADP) open platform communications unified architecture(OPC UA) automated liquid handling curve regression and motion control online accuracy calibration
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Efficient electrocatalytic CO2 reduction by crystalline polymetallophthalocyanine covalent organic frameworks unprecedentedly constructed involving 4-dimethylaminopyridine(DMAP)-type nucleophilic catalyst 认领 引用
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作者 Tao Wei Zhanpeng Liang +6 位作者 Boxin Zhang Yunhao Xu Zhaoxue Sun Minghao Duo Minghui Chen Sheng Zhang Bao Zhang 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 2026年第4期319-329,共11页
Polymetallophthalocyanine covalent organic frameworks(pMPc-COFs)exhibit considerable promise in the electrocatalytic CO2 reduction reaction(CO2RR)due to their tunable active sites and excellent structural stabil... Polymetallophthalocyanine covalent organic frameworks(pMPc-COFs)exhibit considerable promise in the electrocatalytic CO2 reduction reaction(CO2RR)due to their tunable active sites and excellent structural stability.Nevertheless,preparation of crystalline pMPc-COFs under mild conditions remains a significant challenge.Herein,we developed a mild and scalable synthetic strategy,which can realize the construction of pMPc-COFs with different metals embedded.Thus,in the presence of different metal atoms(Co,Bi and Cu),the nucleophilic catalyst 4-dimethylaminopyridine(DMAP)flux-mediated formation of pMPc-COFs occurred efficiently leading to crystalline DMAP-pCoPc-COFs,DMAP-pBiPc-COFs and DMAP-pCuPc-COFs,respectively,incorporated with well-defined single-metal-atom reactive centers at a temperature of 150℃ with no other solvents required.Intriguingly,in the electrocatalytic CO2RR,as-prepared DMAP-pCoPc-COFs demonstrated remarkable CO Faradaic efficiencies above 88% and up to 91% over a wide potential range(-0.8 to-1.0 V vs.RHE).More interestingly,DMAP-pBiPc-COFs,as the first example of Bi phthalocyanine COFs to date,exhibited an encouraging formate selectivity of up to 85%,making it one of the most efficient formate electrocatalysts.The tuning of CO2RR selectivity by the center metal was further revealed from the atomic level through in-situ infrared spectroscopy technique and theoretical calculations,providing new insights for the design of efficient electrocatalysts involving pMPc-COFs. 展开更多
关键词 Covalent organic framework Synthesis method Phthalocyanine Carbon dioxide reduction reaction Electrocatalysis
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Quzhou Fructus Aurantii extract alleviates metabolic dysfunction-associated steatohepatitis by activating the PPARαsignaling pathway 认领 引用
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作者 Lianhao Wu Wenwen Zhu +9 位作者 Shuohan Zhang Ranran Chen Junyi Wang Yiyang Shui Yi Sun Sheng Zhang He Tao Yueguo Wu Yu Yuan Zhenqiang You 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2026年第7期859-874,共16页
Metabolic dysfunction-associated steatohepatitis(MASH)is a chronic metabolic disease that severely affects human health.Quzhou Fructus Aurantii ethyl acetate extract(QFAEE)is a mixture rich in diverse natural flavonoi... Metabolic dysfunction-associated steatohepatitis(MASH)is a chronic metabolic disease that severely affects human health.Quzhou Fructus Aurantii ethyl acetate extract(QFAEE)is a mixture rich in diverse natural flavonoids that exhibits multiple pharmacological properties,including significant anti-inflammatory and antioxidant activities.However,the anti-MASH effects of QFAEE and the underlying mechanisms remain unknown.This study aimed to investigate the therapeutic effects of QFAEE on MASH and the related mechanisms.The therapeutic effects of QFAEE on hepatic steatosis,inflammatory responses,oxidative stress and apoptotic activity were systematically evaluated in both in vivo and in vitro models of metabolic stress.QFAEE administration significantly reduced hepatic lipid accumulation,inflammatory cell infiltration and liver injury in HFHC diet-fed mice.Combined RNA sequencing and network pharmacology analyses revealed that QFAEE exerted its anti-MASH effects through modulation of the PPAR signaling pathway.QFAEE ameliorated MASH by activating PPARαand subsequently upregulating CPT1A,which promoted mitochondrial and peroxisomalβ-oxidation.Notably,PPARαinhibition promoted hepatic lipid accumulation,inflammation and oxidative stress in hepatocytes,all of which were significantly attenuated by QFAEE treatment.These findings suggest that QFAEE prevents metabolic stress-induced MASH progression by activating PPARαsignaling. 展开更多
关键词 Quzhou Fructus Aurantii ethyl acetate extract(QFAEE) Metabolic dysfunction-associated steatohepatitis(MASH) PPAR signaling pathway Peroxisome proliferator-activated receptor alpha(PPARα)
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Navigation value of intraoperative ultrasound combined with indocyanine green fluorescence in complex hepatocellular carcinoma resection 认领 引用
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作者 Sheng Zhang Shao-Ying Li Bing Zhou 《World Journal of Gastrointestinal Surgery》 SCIE 2026年第4期103-117,共15页
BACKGROUND Primary hepatocellular carcinoma(HCC)is a common malignancy worldwide,with surgical resection being the most effective treatment for long-term survival.For complex HCC(large diameter,central location,multip... BACKGROUND Primary hepatocellular carcinoma(HCC)is a common malignancy worldwide,with surgical resection being the most effective treatment for long-term survival.For complex HCC(large diameter,central location,multiple lesions,or proximity to major vessels),traditional surgery relying on surgeon experience and palpation has limitations including difficulty identifying deep lesions and high positive margin rates.Intraoperative ultrasound(IOUS)provides real-time hepatic structural visualization but has limited capability for isoechoic lesions,while indocyanine green(ICG)fluorescence imaging enables real-time tumor visualization but lacks deep anatomical information.Combined application may offer complementary advantages,yet systematic evaluation studies in complex HCC resection remain scarce.AIM To evaluate the clinical application value of IOUS combined with ICG fluorescence imaging technology in radical resection of complex HCC.METHODS Clinical data of 200 patients with complex HCC who underwent radical hepatectomy from January 2019 to August 2024 were retrospectively analyzed.Patients were divided into a combined navigation group(n=103)and a conventional surgery group(n=97)based on whether IOUS and ICG fluorescence imaging technology were used in combination.Intraoperative indicators,oncological indicators,postoperative recovery indicators,and long-term prognosis were compared between the two groups.Logistic regression analysis was used to analyze factors influencing postoperative complications,and Cox regression analysis was used to analyze factors influencing survival prognosis.RESULTS Baseline characteristics were balanced between the two groups.The combined navigation group had shorter tumor localization time(P<0.001),less intraoperative blood loss(P=0.004),lower intraoperative transfusion rate(P=0.021),higher detection rate of occult lesions(23.3%vs 6.2%,P<0.001),and higher anatomical resection rate(P=0.040).The combined navigation group had lower positive margin rate(2.9%vs 13.4%,P=0.006),higher R0 resection rate(97.1%vs 86.6%,P=0.006),and greater margin distance(P<0.001).The combined navigation group had lower overall postoperative complication rate(18.4%vs 28.9%,P=0.042)and severe complication rate(5.8%vs 12.4%,P=0.042),and shorter postoperative hospital stay(P=0.003).With a median follow-up of 28.6 months,the combined navigation group had higher 2-year overall survival rate(76.8%vs 65.2%,P=0.033)and 2-year diseasefree survival rate(58.4%vs 45.7%,P=0.022),and lower postoperative recurrence rate(36.9%vs 50.5%,P=0.048).Multivariate analysis showed that application of combined navigation technology was an independent protective factor for postoperative complications(odds ratio=0.498,P=0.027),and was also an independent protective factor for overall survival(hazard ratio=0.584,P=0.028)and disease-free survival(hazard ratio=0.631,P=0.025).CONCLUSION IOUS combined with ICG fluorescence imaging technology can improve tumor localization accuracy in complex HCC surgery,improve margin control,reduce intraoperative blood loss,decrease the incidence of postoperative complications,and improve long-term survival prognosis in patients,demonstrating important clinical application value. 展开更多
关键词 Hepatocellular carcinoma Complex hepatocellular carcinoma Intraoperative ultrasound Indocyanine green fluorescence imaging Surgical navigation Precision hepatectomy
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Eugenol accelerates intestinal stem cell regeneration to protect the intestinal barrier integrity through inhibiting JAK2/STAT3 signaling pathway in Salmonella enteritidis-challenged broiler chicks 认领 引用 被引量：4
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作者 Yaxue Lv Nan Zeng +3 位作者 Yuqing Feng Sheng Zhang Xiaodan Zhou Chunqi Gao 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2025年第3期1416-1429,共14页
Background Salmonella enteritidis is a prevalent foodborne pathogen causing diseases in humans and poultry globally.While clove extract is known for its anti-inflammatory properties,its specific effects on gut injury ... Background Salmonella enteritidis is a prevalent foodborne pathogen causing diseases in humans and poultry globally.While clove extract is known for its anti-inflammatory properties,its specific effects on gut injury and underlying mechanisms are not well understood.Methods A total of 432 one-day-old male fast-growing yellow-feathered broilers with similar body weight were randomly assigned to 6 groups,the CON and S.E were fed a basal diet;the CE and S.E+CE received 300 mg/kg of clove extract in their diets;and the EUG and S.E+EUG had 180 mg/kg of eugenol added to their basal diets.Moreover,a newly established ex vivo culture model for chick intestinal organoids(IOs)was used to evaluate intestinal stem cell(ISC)activity.Results Salmonella enteritis infection significantly reduced the growth performance and induced severe intestinal mucosa injury(P<0.05).Dietary supplemented with clove extract or eugenol significantly improved average daily weight gain and feed intake,enhanced the structure and barrier function of the jejunum,reduced the bacterial load and diarrhea scores,promoted the proliferation and differentiation of ISCs,and diminished the efficiency,surface area,budding efficiency,and number of buds of intestinal organoids(P<0.05).Both clove extract and eugenol downregulated the protein expression of pro-inflammatory cytokines IL-1β,IL-6,and TNF-α.They also inhibited the excessive activation of the JAK2/STAT3 signaling pathway induced by Salmonella enteritidis infection in the jejunum tissues and crypts of chicks(P<0.05).Conclusions Eugenol,the active component in clove extract,alleviates intestinal inflammation by inhibiting the excessive activation of the JAK2/STAT3 signaling pathway.It promotes the proliferation and differentiation of ISCs,suppresses apoptosis,and accelerates ISCs-driven intestinal epithelial renewal in chicks,thereby maintaining the structural integrity and functional normalcy of the intestine. 展开更多
关键词 Eugenol Inflammatory response Intestinal barrier Salmonella Stem cell activity
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Mechanistic studies of the beneficial effects of Anshen Dingzhi prescription for PTSD treatment:roles of the FKBP5-IKKα-NF-κB-NLRP3 signaling pathway 认领 引用 被引量：3
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作者 Daokang Chen Jiamin Hu +6 位作者 Shaojie Yang Pan Xie Manman Ji Zhengrong Zhang Michel Baudry Sheng Zhang Guoqi Zhu 《Acupuncture and Herbal Medicine》 CAS CSCD 2025年第3期316-327,共12页
Objective:Anshen Dingzhi prescription(ADP)is an effective remedy for treating post-traumatic stress disorder(PTSD);however,the mechanism underlying its beneficial effects is unclear.This study explores the roles of th... Objective:Anshen Dingzhi prescription(ADP)is an effective remedy for treating post-traumatic stress disorder(PTSD);however,the mechanism underlying its beneficial effects is unclear.This study explores the roles of the neuroinflammation regulated by the FKBP prolyl isomerase 5(FKBP5)-IκB kinase alpha(IKKα)-nuclear factor kappa-B(NF-κB)-NOD-like receptor thermal protein domain-associated protein 3(NLRP3)signaling pathway in PTSD.Methods:The primary components of ADP,including ginsenosides Rg1 and Rb1,were quantified using ultra-performance liquid chromatography.Twelve C57BL/6 mice were allocated to control(D0)and experimental groups on days one,seven,and 14 of single prolonged stress(SPS).Eighteen C57BL/6 mice were allocated to control,SPS,and MCC950,an NLRP3 inhibitor(5 mg/kg)groups.Finally,24 C57BL/6 mice were allocated to control,SPS,paroxetine hydrochloride(PRX),or ADP(18.4 and 36.8 mg/kg)groups.Mice were administered MCC950,PRX,or ADP for 14 days.The open field test and elevated plus maze were used to evaluate anxiety-like behaviors,whereas fear memory extinction was evaluated using the fear memory test.Western blotting was employed to evaluate the expression levels of the FKBP5-IKKα-NF-κB-NLRP3 signaling pathway,tumor necrosis factor-α(TNF-α),interleukin(IL)-6,and IL-1β.The expression of FKBP5 and NLRP3 was further confirmed by immunofluorescence staining.Results:The amounts of ginsenosides Rg1 and Rb1 in ADP were(96.85±1.14)and(9.04±0.22)μg/g,respectively.Compared with the D0 group,the levels of the inflammatory cytokine proteins,TNF-α,IL-6,and IL-1β were elevated 1.33-to 1.51-fold and those of FKBP5-IKKα-NF-κB-NLRP3 signaling pathway were increased 1.16-to 1.41-fold in the hippocampus of the D14 group(P<0.05);the fluorescence intensity of FKBP5 and NLRP3 was also markedly increased(1.33-1.79-fold)in the hippocampus of the D14 group(P<0.5).Notably,injection of MCC950(5 mg/kg)reduced the levels of FKBP5-IKKα-NF-κB-NLRP3(0.80-0.88-fold)and inflammatory cytokines(0.74-0.83-fold),thereby improving the PTSD-like behaviors induced by SPS(P<0.05).In addition,ADP(36.8 g/kg)significantly improved PTSD-like behaviors and reduced levels of hippocampal inflammatory cytokines(0.70-0.79-fold)and FKBP5-IKKα-NF-κB-NLRP3(0.50-0.79-fold)(P<0.05)in SPS mice.Conclusion:The results suggest a potential therapeutic benefit of ADP in PTSD due to the inhibition of the FKBP5-IKKα-NF-κBNLRP3 signaling pathway. 展开更多
关键词 Anshen Dingzhi prescription FKBP5-IKKα-NF-κB-NLRP3 signaling pathway Neuroinflammation Post-traumatic stress disorder
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Janus-inspired alternating architecture CNF/MXene/ZnFe2O4@PANI composite films with outstanding electromagnetic interference shielding and Joule heating 认领 引用 被引量：2
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作者 Lian Yin Jiale Zhang +4 位作者 Jianjian Luo Yongqian Shi Bin Yu Sheng Zhang Keqing Zhou 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2025年第20期275-286,共12页
With the continuous advancement of electronic devices,flexible thin films with both thermal manage-ment functions and excellent electromagnetic interference(EMI)shielding properties have received much attention.Hence,... With the continuous advancement of electronic devices,flexible thin films with both thermal manage-ment functions and excellent electromagnetic interference(EMI)shielding properties have received much attention.Hence,inspired by Janus,a CNF/MXene/ZnFe2O4@PANI composite film with an asymmetric gradient alternating structure was successfully prepared by adjusting the filler content of the conduc-tive and magnetic layers using a vacuum-assisted filtration method.Benefiting from the magnetic reso-nance and hysteresis loss of ZnFe2O4@PANI,conductive loss and dipole polarization of MXene,as well as the exclusive"absorption-reflection-reabsorption"shielding feature in the alternating multilayered films,CM&CZFP-4 G film has superior EMI shielding performance,with an EMI SE of up to 45.75 dB and shield-ing effectiveness of 99.99%.Surprisingly,the composite film maintains reliable EMI shielding properties even after prolonged erosion in harsh environments such as high/low temperatures,high humidity,acids and alkalis.Furthermore,the CM&CZFP-4 G responded quickly within about 50 s and reached a maximum steady-state temperature of 235.8℃ at an applied voltage of 9.0 V,indicating the obtained film acquired outstanding and controllable Joule heating performance.This result was attributed to the homogeneous dispersion of MXene to build up a conductive network and endow the CNF/MXene with high conduc-tivity.Meanwhile,the fire resistance of CM&CZFP-4 G was significantly improved compared to pure CNF,which guaranteed fire safety during its application.Additionally,contributed by long fiber entanglement of CNF,extensive hydrogen-bonding interactions and multilayer structural design,the CM&CZFP-4 G film exhibits excellent mechanical characteristics,with the tensile strength and fracture strain of 27.74 MPa and 6.21%,separately.This work offers a creative avenue to prepare multifunctional composite films with electromagnetic shielding and Joule heating for various application environments. 展开更多
关键词 MXene Asymmetric Alternating architecture Electromagnetic interference shielding Joule heating
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Baicalein attenuates lipopolysaccharide-induced myocardial injury by inhibiting ferroptosis via miR-299b-5p/HIF1-a pathway 认领 引用 被引量：1
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作者 Wen-yan Zhou Jian-kui Du +5 位作者 Hong-hong Liu Lei Deng Kai Ma Jian Xiao Sheng Zhang Chang-nan Wang 《Journal of Integrative Medicine》 SCIE CAS CSCD 2025年第5期560-575,共16页
Objective:Baicalein has been reported to have wide therapeutic effects that act through its antiinflammatory activity.This study examines the effect and mechanism of baicalein on sepsis-induced cardiomyopathy(SIC).Met... Objective:Baicalein has been reported to have wide therapeutic effects that act through its antiinflammatory activity.This study examines the effect and mechanism of baicalein on sepsis-induced cardiomyopathy(SIC).Methods:A thorough screening of a small library of natural products,comprising 100 diverse compounds,was conducted to identify the most effective drug against lipopolysaccharide(LPS)-treated H9C2 cardiomyocytes.The core target proteins and their associated signaling pathways involved in baicalein's efficacy against LPS-induced myocardial injury were predicted by network pharmacology.Results:Baicalein was identified as the most potent protective agent in LPS-exposed H9C2 cardiomyocytes.It exhibited a dose-dependent inhibitory effect on cell injury and inflammation.In the LPSinduced septic mouse model,baicalein demonstrated a significant capacity to mitigate LPS-triggered myocardial deficits,inflammatory responses,and ferroptosis.Network pharmacological analysis and experimental confirmation suggested that hypoxia-inducible factor 1 subunit a(HIF1-a)is likely to be the crucial factor in mediating the impact of baicalein against LPS-induced myocardial ferroptosis and injury.By combining microRNA(miRNA)screening in LPS-treated myocardium with miRNA prediction targeting HIF1-a,we found that miR-299b-5p may serve as a regulator of HIF1-a.The reduction in miR-299b-5p levels in LPS-treated myocardium,compared to the control group,was reversed by baicalein treatment.The reverse transcription quantitative polymerase chain reaction,Western blotting,and dual-luciferase reporter gene analyses together identified HIF1-a as the target of miR-299b-5p in cardiomyocytes.Conclusion:Baicalein mitigates SIC at the miRNA level,suggesting the therapeutic potential of it in treating SIC through the regulation of miR-299b-5p/HIF1-a/ferroptosis pathway. 展开更多
关键词 Sepsis Myocardial injury Baicalein miR-299b-5p Hypoxia-inducible factor 1 subunit a Ferroptosis
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Significant spatiotemporal pattern of nitrous oxide emission and its influencing factors from a shallow eutropic lake in Inner Mongolia,China 认领 引用
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作者 Guohua Li Sheng Zhang +8 位作者 Xiaohong Shi Shengnan Zhao Liyang Zhan Xueru Pan Fan Zhang Haifeng Yu Yue Sun Lauri Arvola Jussi Huotari 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2025年第3期488-499,共12页
Eutrophic shallow lakes are generally considered as a contributor to the emission of nitrous oxide(N2O),while regional and global estimates have remained imprecise.This due to a lack of data and insufficient unders... Eutrophic shallow lakes are generally considered as a contributor to the emission of nitrous oxide(N2O),while regional and global estimates have remained imprecise.This due to a lack of data and insufficient understanding of the multiple contributing factors.This study characterized the spatiotemporal variability in N2O concentrations and N2O diffusive fluxes and the contributing factors in LakeWuliangsuhai,a typical shallow eutrophic and seasonally frozen lake in Inner Mongolia with cold and arid climate.Dissolved N2O concentrations of the lake exhibited a range of 4.5 to 101.2 nmol/L,displaying significant spatiotemporal variations.The lowest and highest concentrations were measured in summer and winter,respectively.The spatial distribution of N2Ofluxwas consistent with that of N2O concentrations.Additionally,the hotspots of N2O emissions were detected within close to the main inflow of lake.The wide spatial and temporal variation in N2O emissions indicate the complexity and its relative importance of factors influencing emissions.N2O emissions in different lake zones and seasons were regulated by diverse factors.Factors influencing the spatial and temporal distribution of N2O concentrations and fluxes were identified as WT,WD,DO,Chl-a,SD and COD.Interestingly,the same factor demonstrated opposing effects on N2O emission in various seasons or zones.This research improves our understanding of N2O emissions in shallow eutrophic lakes in cold and arid areas. 展开更多
关键词 Nitrous oxide Spatial and temporal variation Controlling factors Shallow lakes
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Locating acoustic emission sources in pseudo-triaxial experiments with the shortest path and orthogonal constraint 认领 引用
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作者 Yichao Rui Yuanyuan Pu +5 位作者 Jie Chen Cunjin Zhu Sheng Zhang Jiongkun Chen Zelin Zhou Wenzhong Wang 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2025年第9期5453-5464,共12页
Acoustic waves in the pseudo-triaxial experiment system experience refraction phenomena.The conventional assumption that acoustic waves propagate along a straight line in traditional methods can lead to significant er... Acoustic waves in the pseudo-triaxial experiment system experience refraction phenomena.The conventional assumption that acoustic waves propagate along a straight line in traditional methods can lead to significant errors in localization results.To the end,this paper presents a method for locating acoustic emission(AE)sources in pseudo-triaxial experiments using shortest paths and orthogonal constraints.The approach consists of three main steps:(1)establishing control equations for refraction paths from AE sources to sensor locations;(2)calculating refraction point locations using the shortest travel principle and orthogonal constraints;(3)determining source coordinates using Taylor's first-order expansion.The results from laboratory AE experiments demonstrate that the average localization accuracy of the new method is only 6.5 mm,which is 66%more precise than the accuracy(19.4 mm)of the traditional method.Furthermore,simulation results indicate that the new method is not affected by the refraction ratio of the media and maintains the highest positioning accuracy across various arrival and velocity errors. 展开更多
关键词 Acoustic emission(AE) Source localization Pseudo-triaxial experiment Shortest path Orthogonal constraint
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Hydraulic strategies of Cunninghamia lanceolata under drought are shaped by native drought conditions 认领 引用
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作者 Jian Feng Yuan Yao +3 位作者 Yue He Pei Wang Hanying Hu Sheng Zhang 《Forestry Research》 2025年第1期1-13,共13页
Cunninghamia lanceolata is integral to soil conservation,climate regulation,and biodiversity maintenance,yet its ecological functions are threatened by drought.Functional trait trade-offs underpin hydraulic safety,but... Cunninghamia lanceolata is integral to soil conservation,climate regulation,and biodiversity maintenance,yet its ecological functions are threatened by drought.Functional trait trade-offs underpin hydraulic safety,but the plasticity of hydraulic strategies in C.lanceolata remains poorly understood.Here,the historical intensity of drought across different C.lanceolata regions were quantified using the Temperature Vegetation Dryness Index(TVDI)derived from satellite remote sensing.Seedlings sourced from these regions were subjected to drought under greenhouse conditions,and then water status,physiological traits,and metabolic responses were assessed to elucidate hydraulic strategies.The results revealed that TVDI effectively captured regional drought patterns,with the Dechang region experiencing the highest drought intensity,followed by the Hongya and Shiyan regions.The seedlings exhibited distinct hydraulic responses under drought stress.The highest drought-originated seedlings maintained a stable leaf water status,imposed stricter regulation of stomatal and biomass,and accumulated higher levels of antioxidants and defense compounds,indicative of a conservative strategy.In contrast,the low drought-originated seedlings showed greater fluctuations in leaf water content and potential,retained more aboveground biomass,and accumulated fewer defense compounds,reflecting an acquisitive strategy.The moderate drought-originated seedlings adopted an intermediate strategy,balancing growth and antioxidant accumulation.Overall,as the intensity of the drought increased across the provenances,C.lanceolata shifted from an acquisitive to a conservative hydraulic strategy.By linking provenance-specific drought regimes with physiological and metabolic responses,this study provides new insights into drought resistance mechanisms and informs species selection and forest management under climate change. 展开更多
关键词 plasticity hydraulic strategies temperature vegetation dryness index historical intensity drought cunninghamia lanceolata temperature vegetation dryness satellite remote sensingseedlings drought resistance hydraulic strategies
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Radiotherapy for large ruptured hemorrhagic axillary lymph node metastasis from anaplastic lymphoma kinase-positive lung adenocarcinoma:A case report and review of literature 认领 引用
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作者 Zhi-Min Li Yang-Chenxi Wang +7 位作者 Kai-Yue Wang Ning-Jing Xie Jun Zhou Xiao-Na Chang Quan Chen Geng Wang Sheng Zhang Rui Zhou 《World Journal of Clinical Oncology》 2025年第12期215-224,共10页
BACKGROUND Anaplastic lymphoma kinase(ALK)gene fusion is a molecular subtype of nonsmall cell lung cancer,representing 4%-6%of lung adenocarcinomas.Axillary lymph node(ALN)metastasis from lung cancer is rare,and massi... BACKGROUND Anaplastic lymphoma kinase(ALK)gene fusion is a molecular subtype of nonsmall cell lung cancer,representing 4%-6%of lung adenocarcinomas.Axillary lymph node(ALN)metastasis from lung cancer is rare,and massive bleeding from such lesions is an even more unusual and life-threatening complication.This case demonstrates how localized radiotherapy can be used as an effective hemostatic and tumor-controlling measure when conventional interventions fail.CASE SUMMARY A 48-year-old male presented in October 2019 with ALK-positive lung adenocarcinoma and multiple metastases.He received multiple lines of ALK tyrosine kinase inhibitor therapy,whole-brain radiotherapy,stereotactic radiotherapy,chemotherapy,and targeted agents over 4 years and 7 months.In February 2024,rapid enlargement and rupture of a left ALN metastasis caused massive bleeding.Interventional and surgical hemostasis were not feasible.Localized radiotherapy was initiated at 15 Gray in 5 fractions,later increased to a total of 39 Gray in 13 fractions,resulting in rapid bleeding control and partial tumor response.The patient subsequently received chemotherapy,and the axillary lesion healed without recurrent bleeding.However,three months later,he developed severe pneumonia with mixed bacterial,mycobacterial,and fungal infections and died despite intensive care.CONCLUSION Radiotherapy can effectively control bleeding and achieve local tumor control in ALK-positive lung cancer with ruptured ALN metastasis when other treatments are ineffective. 展开更多
关键词 Anaplastic lymphoma kinase fusion Lung adenocarcinoma Radiation therapy Axillary lymph node metastasis Bleeding Case report
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Investigations of inelastic cross sections of H2O molecule by He2+ and C6+ projectiles with energy range around the Bragg peak 认领 引用
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作者 Guo-Zhuang Li Cheng-Ye Sun +5 位作者 Rui Cheng Yan-Shi Zhang Liang-Wen Chen Sheng Zhang Xin-Xia Li Lei Yang 《Nuclear Science and Techniques》 SCIE EI CAS CSCD 2025年第2期141-154,共14页
Inelastic collisions are the dominant cause of energy loss in radiotherapy.In the energy range around the Bragg peak,single ionization(SI)and single-electron capture(SC)are the primary inelastic collisions that lead t... Inelastic collisions are the dominant cause of energy loss in radiotherapy.In the energy range around the Bragg peak,single ionization(SI)and single-electron capture(SC)are the primary inelastic collisions that lead to energy loss.This study employs the classical trajectory Monte Carlo method to study the SI and SC processes of H2O molecules using He2+ and C6+ projectiles in the energy range of 10 keV/u to 10 MeV/u.The total cross sections,single differential cross sections,impact parameter dependence of SI and SC,and fragmentation cross sections were investigated.Results illustrate that the cross section for SI is the highest when the projectile energy is close to the Bragg peak energy.When the projectile energy is below the Bragg peak energy,the ionized electrons in the forward direction dominate,and the removal of electrons can be associated with large impact parameters.As the projectile energy increases,the emission angle of the electrons gradually transitions from small angles(60°~120°)to large angles(60°~120°),and the removal of electrons is associated with small impact parameters.The energy distributions of the ionized electron are similar when the projectile energy is equal to,below or above the Bragg peak energy.The fragmentation cross sections after SI and SC in the energy range around the Bragg peak were also estimated. 展开更多
关键词 Classical trajectory Monte Carlo Heavy ion-water molecule collision Inelastic cross sections
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