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Preparation and characterization of microalgae-derived extracellular vesicles and their protective effect on acute alcohol-induced liver injury 认领 引用
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作者 Jiawen Song Lei Zhou +2 位作者 Shengfeng Peng David Julian McClements Wei Liu 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第5期2310-2322,共13页
Increased levels of alcohol consumption are linked to an increased risk of alcoholic liver disease.As a novel source of national food,microalgae are rich in bioactives and have been demonstrated to confer benefits to ... Increased levels of alcohol consumption are linked to an increased risk of alcoholic liver disease.As a novel source of national food,microalgae are rich in bioactives and have been demonstrated to confer benefits to human health.The effects of microalgae extracellular vesicles(M-EVs)on alcohol-induced liver injury have not been studied previously.In this study,3 types of M-EVs were isolated using a combination of tangential flow filtration(TFF)and size exclusion chromatography(SEC).The structure and composition of M-EVs were characterized and the safety and liver-accumulation of M-EVs were also confirmed.Results shown that 3 types M-EVs were shown to be colloidal particles((198.9±7.2),(191.7±5.1),and(259.5±8.1)nm)with negative charge((-25.0±1.6),(-21.4±0.6),and(-22.4±1.6)mV).M-EVs were able to reduce the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),and triglycerides(TGs)in the mice and regulated the levels of malondialdehyde(MDA),glutathione(GSH),and superoxide dismutase(SOD),which protected the mice against oxidative damage and inflammation caused by alcohol-induced liver injury.In addition,the M-EVs may also have alleviated alcohol-induced liver injury through activation of the Nrf2/HO-1 signaling pathway and regulation of CYP2E1 expression,as well as by modulating the diversity and composition of the gut microbiota.The potentially beneficial effects of M-EVs on alcoholic liver disease may provide a theoretical basis for further exploration of the health function of M-EVs in the food industry. 展开更多
关键词 Alcohol-induced liver injury Microalgae Extracellular vesicles Nrf2/HO-1 signaling pathway Gut microbiota
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Improving hepatoprotective effect of naringin against alcohol-induced liver injury by encapsulation in microalgae-derived extracellular vesicles 认领 引用 被引量：1
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作者 Jiawen Song Qianqian Jiao +4 位作者 Lei Zhou Shengfeng Peng Suyun Lin David Julian McClements Wei Liu 《Food Bioscience》 SCIE 2025年第2期1478-1492,共15页
Naringin is a dietary flavonoid that exhibits hepatoprotective effects against alcoholic liver disease(ALD).However,its hepatoprotective potential is limited by its low solubility,bioavailability,and bioactivity.In th... Naringin is a dietary flavonoid that exhibits hepatoprotective effects against alcoholic liver disease(ALD).However,its hepatoprotective potential is limited by its low solubility,bioavailability,and bioactivity.In this study,Scenedesmus-derived extracellular vesicles(SEVs)were successfully isolated,characterized,and utilized as delivery systems.Naringin was successfully loaded into the SEVs(Nar-SEVs)using a pH-driven method.The Nar-SEVs displayed high encapsulation efficiency,good storage stability,cytocompatibility,and liver-targeting.An in vivo mice study showed that Nar-SEVs reduced oxidative stress and inflammation in the liver,thereby protecting it from alcohol-induced injury.Moreover,Nar-SEVs alleviated alcohol-induced liver injury through activation of the Nrf2/HO-1 signaling pathway and regulation of CYP2E1 expression,as well as by modulating the diversity and composition of the gut microbiota.These results may facilitate the development of naringin-based functional foods,supplements and drugs designed to target ALD. 展开更多
关键词 Alcohol-induced liver injury Naringin Extracellular vesicles Nrf2/HO-1 signaling pathway Gut microbiota
Moisture-responsive essential oil composite paper based on metal-organic framework for lily bulb preservation 认领 引用 被引量：1
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作者 Xiaowei Chen Yuhao Huang +7 位作者 Junping Liu Kaibo Yu Yangyang Li Wenjing Tan Linfeng Yuan Shengfeng Peng Lei Zhou Wei Liu 《Food Bioscience》 SCIE 2025年第3期514-528,共15页
The preservation of lily bulbs has attracted attention due to the reduction of shelf life caused by high humidity.In this study,a moisture-responsive carboxymethyl absorbent paper embedded with HKUST-1(HKUST-1@CMAP)wa... The preservation of lily bulbs has attracted attention due to the reduction of shelf life caused by high humidity.In this study,a moisture-responsive carboxymethyl absorbent paper embedded with HKUST-1(HKUST-1@CMAP)was successfully prepared by in-situ growth method.Characteristic peaks and crystallization peaks of HKUST-1 were observed in the FTIR spectra and XRD spectra of HKUST-1@CMAP,respectively.The loading capacity of clove essential oil(CEO)in composite paper was 4.62%.Essential oil composite paper(CEO-HKUST-1@CMAP)exhibited moisture-responsive release properties,with the release of clove essential oil increasing from 34.99%to 84.38%within 18 days as the moisture increased from 20%to 60%.Meanwhile,CEO-HKUST-1@CMAP showed excellent antimicrobial capacity,antioxidant property and biocompatibility.During storage,essential oil composite paper effectively delayed the browning of lily bulbs,maintained their firmness,and inhibited the growth of microorganisms,thereby maintaining the overall storage quality of lily bulbs stored at 25℃ for 16 days.In addition,CEO-HKUST-1@CMAP successfully improved cell membrane integrity by enhancing the activities of SOD and APX,inhibiting the activity of POD,and reducing the accumulation of MDA.In conclusion,CEO-HKUST-1@CMAP effectively prolonged the shelf life of lily bulbs,indicating that it is a promising preservative for the preservation of lily bulbs. 展开更多
关键词 Carboxymethyl absorbent paper Clove essential oil HKUST-1 Moisture responsive Shelf life
Lignification process and related metabolism in green asparagus(Asparagus officinalis L.)at different storage temperatures 认领 引用
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作者 Yangyang Li Xiongfeng Zhang +6 位作者 Junping Liu Kaibo Yu Xiaowei Chen Linfeng Yuan Shengfeng Peng Lei Zhou Wei Liu 《Food Quality and Safety》 SCIE CAS CSCD 2025年第3期464-482,共19页
As a valuable vegetable,harvested asparagus(Asparagus officinalis L.)is prone to lignification due to active metabolic activity and unsuitable storage.Currently,the lignification process and related metabolism in aspa... As a valuable vegetable,harvested asparagus(Asparagus officinalis L.)is prone to lignification due to active metabolic activity and unsuitable storage.Currently,the lignification process and related metabolism in asparagus at different temperatures remain unclear.In this study,asparagus was stored at 25℃ or 4℃,after which its storage quality,lignin content,lignin distribution,and lignification-related metabolism,such as phenylpropanoid,reactive oxygen species,and cell wall metabolism,were analyzed.The results showed that the nutritional quality steadily declined at 25℃,whereas the lignin content and firmness increased rapidly with increasing storage time.On the other hand,4℃ effectively delayed lignification and maintained storage quality.Chemical staining and autofluorescence showed that lignin was primarily deposited in vascular bundles and subepidermal tissues.At 25℃,the elevated activity of phenylpropanoid metabolism enzymes was a pivotal trigger for lignification of asparagus.Correlation analysis showed that reactive oxygen species metabolism and cell wall metabolism are closely associated with lignification.Excessive reactive oxygen species may be involved in the polymerization of lignin monomers and the activation of phenylpropanoid metabolism,whereas cellulose and hemicellulose may cross-link with lignin within the cell wall.The synergistic effect of these three metabolic processes contributed to lignification,increasing lignin content by 90.47%and firmness by 43.85%,directly reducing sensory and commercial quality.Low temperature effectively controlled the metabolism of these three genes,thereby delaying lignification.This study provides a theoretical basis for the development of asparagus preservation technology. 展开更多
关键词 Green asparagus postharvest quality lignification autofluorescence phenylpropanoid metabolism
Alleviation of ulcerative colitis via curcumin-fortified orange juice: Utilization of orange-derived extracellular vesicles as active nanocarrier 认领 引用 被引量：1
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作者 Hang Liu Zhuoya Wang +5 位作者 Cihua Zheng Lei Zhou Shengfeng Peng David Julian McClements Chengmei Liu Wei Liu 《Food Bioscience》 SCIE 2024年第6期5660-5672,共13页
There is evidence that consumption of fruit and vegetable juices may alleviate ulcerative colitis.However,their application is limited because of their relatively weak and uncertain health benefits.In this study,curcu... There is evidence that consumption of fruit and vegetable juices may alleviate ulcerative colitis.However,their application is limited because of their relatively weak and uncertain health benefits.In this study,curcuminfortified orange juice(Cur-OJ)was produced using orange extracellular vesicles as natural active nanocarriers.The concentration,composition,morphology and size of extracellular vesicles were first determined.It was shown that curcumin was incorporated into the lipid bilayer of extracellular vesicles in an amorphous form.The influences of oral administration of Cur-OJ on DSS-triggered colitis mice was evaluated.Cur-OJ reduced the pathological symptoms in mice,affected the expression of inflammatory cytokine,and improved the integrity of the colon tissue through enhancing the levels of three tight junction proteins.The gut microflora and colonic metabolites of colitis mice in Cur-OJ group were close to those in control group.Noticeably,the treatment of colitis was better in the Cur-OJ group than those in curcumin or orange juice groups,suggesting that curcumin and orange juice can work together to relieve colitis symptoms.In summary,this study showed that Cur-OJ can reduce colitis,which may be useful for the progress of novel functional fruit or vegetable juice and foods designed to improve body health and human wellbeing. 展开更多
关键词 Orange juice Curcumin Extracellular vesicle Ulcerative colitis Additive treatment
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