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Clinical efficacy of tolvaptan for treatment of refractory ascites in liver cirrhosis patients 认领 引用 被引量：45
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作者 Xin Zhang Shu-Zhen Wang +7 位作者 Jun-Fu Zheng Wen-Min Zhao Peng Li Chun-Lei Fan Bing Li Pei-Ling Dong Lei Li Hui-Guo Ding 《World Journal of Gastroenterology》 SCIE CAS 2014年第32期11400-11405,共6页
AIM: To evaluate the efficacy and safety of tolvaptan to treat refractory ascites in decompensated liver cirrhosis patients with or without further complications, such as hepatorenal syndrome and/or hepatocellular car... AIM: To evaluate the efficacy and safety of tolvaptan to treat refractory ascites in decompensated liver cirrhosis patients with or without further complications, such as hepatorenal syndrome and/or hepatocellular carcinoma. 展开更多
关键词 Tolvaptan Refractory ascites Hyponatremia Decompensation Liver cirrhosis
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Significance of serum glucagon-like peptide-1 and matrix Gla protein levels in patients with diabetes and osteoporosis 认领 引用 被引量：10
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作者 Fei-Fei Xie Yu-Fang Zhang +4 位作者 Yan-Fang Hu Yun-Yun Xie Xiao-Ying Wang Shu-Zhen Wang Bao-Qiang Xie 《World Journal of Clinical Cases》 SCIE 2022年第5期1527-1535,共9页
BACKGROUND Osteoporosis is a systemic bone disease characterized by decreased bone mass,impaired bone mass,and reduced bone strength that leads to increased bone fragility and fracture.Type 2 diabetes mellitus(T2DM)co... BACKGROUND Osteoporosis is a systemic bone disease characterized by decreased bone mass,impaired bone mass,and reduced bone strength that leads to increased bone fragility and fracture.Type 2 diabetes mellitus(T2DM)complicated with osteoporosis is a common systemic metabolic bone disease,and reduced bone mass and bone strength are considered the main clinical features;however,the pathogenesis of this disease has not been fully clarified.Its occurrence is considered related to sex,age,and genetic factors.There are many risk factors for diabetes complicated with osteoporosis.Therefore,exploring these risk factors will help prevent it.AIM To investigate the relationships among serum glucagon-like peptide-1(GLP-1)levels,matrix Gla protein(MGP)levels,and diabetes with osteoporosis.METHODS Sixty patients with T2DM complicated with osteoporosis confirmed by the endocrinology department of our hospital were selected as the case group.Sixty T2DM patients with bone loss were selected as the control group.Sixty healthy participants were selected as the healthy group.The general data,bone mineral density index,and bone metabolic markers of the three groups were compared.The relationships among GLP-1 levels,MGP levels,and the bone mineral density index of the case group were analyzed using linear correlation analysis and a logistic regression model.RESULTS Differences in sex,smoking,and drinking among the case group,control group,and healthy group were not statistically significant(P>0.05).The mean age of the case group was older than those of the control and healthy groups(P<0.05).The body mass index,fasting plasma glucose level,HbA1c level,hypertension rate,and coronary heart disease rate of the case and control groups were higher than those of the healthy group(P<0.05).The serum GLP-1 and MGP levels of the case group were lower than those of the control and healthy groups;these differences were statistically significant(P<0.05).The serum GLP-1 and MGP levels of the control group were lower than those of the healthy group;these differences were statistically significant(P<0.05).The serum GLP-1 and MGP levels of the case group were significantly positively correlated with the bone mineral density values of the hip and lumbar spine(P<0.05).The results of the logistic regression model showed that age and duration of diabetes were independent risk factors for osteoporosis in diabetic patients(P<0.05)and that increased GLP-1 and MGP values were protective factors against osteoporosis in diabetic patients(P<0.05).CONCLUSION Serum GLP-1 and MGP levels of diabetic patients with osteoporosis were significantly decreased and positively correlated with bone mineral density and were independent risk factors for osteoporosis in diabetic patients. 展开更多
关键词 Glucagon-like peptide-1 Matrix Gla protein Diabetes mellitus Osteoporosis Bone mineral density Systemic bone disease
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Inguinal endometriosis: Ten case reports and review of literature 认领 引用 被引量：1
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作者 Shu-Hong Li Heng-Zi Sun +1 位作者 Wei-Hua Li Shu-Zhen Wang 《World Journal of Clinical Cases》 SCIE 2021年第36期11406-11418,共13页
BACKGROUND To describe the characteristics,diagnosis and surgical treatment of inguinal endometriosis(IEM).CASE SUMMARY We retrospectively analyzed 10 patients diagnosed with IEM at Beijing Chao-Yang Hospital from 201... BACKGROUND To describe the characteristics,diagnosis and surgical treatment of inguinal endometriosis(IEM).CASE SUMMARY We retrospectively analyzed 10 patients diagnosed with IEM at Beijing Chao-Yang Hospital from 2011 to 2019.Relevant features,symptoms,images,surgical treatment,hormonal therapy and follow-up were collected and discussed.A total of 10 cases of IEM diagnosed by surgery and pathology were characterized by a lesion on the right side(9/11);five patients had symptoms related to the menstrual cycle,and only 3 patients were clearly diagnosed before surgery.Ultrasonography was of little assistance in confirming the diagnosis,but magnetic resonance imaging showed specific,high-intensity patterns.Anatomically,most of the IEM lesions were located in the extraperitoneal ligament(10/11);nine patients had inguinal hernias(IH),five had concurrent or prior pelvic endometriosis,and four had infertility.The clinical results from extensive resection were satisfactory.CONCLUSION IEM is an extremely rare condition that can easily be misdiagnosed prior to surgery.A right IH may contribute to the formation of right-sided IEM,and extensive resection involving the round ligament and hernia sac is essential to prevent recurrence. 展开更多
关键词 Inguinal endometriosis Clinical characteristics Imaging examination Pelvic endometriosis Treatment Case report
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Rapamycin liposome gutta inhibiting fungal keratitis of rats 认领 引用 被引量：3
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作者 Zhen-Hua Zhang Feng Teng +3 位作者 Qing-Xiu Sun Shu-Zhen Wang Chao Liu Gui-Qiu Zhao 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2019年第4期536-541,共6页
AIM: To study the therapeutic effect of rapamycin liposome eyedrops on fungal keratitis(FK) and its effect on the expression of monocyte chemotactic protein-1(MCP-1).METHODS: This study adopted the thin film dispersio... AIM: To study the therapeutic effect of rapamycin liposome eyedrops on fungal keratitis(FK) and its effect on the expression of monocyte chemotactic protein-1(MCP-1).METHODS: This study adopted the thin film dispersion method to prepare rapamycin liposomes eyedrops, as well as used the orthogonal design to analyze and study main influencing factors that affected the quality of liposomes. Totally 96 healthy Wistar rats were randomly divided into four groups: normal control group(A), FK blank control group(B), FK blank liposomes control group(C), and 30 FK rapamycin liposome treatment group(D). Groups B, C, and D were first prepared as FK animal models. The corneal response was recorded in details on day 1, 3, 5, 7, and 14 after modeling. Six rats were obtained and immunohistochemistry and semi-quantitative reverse transcription polymerase chain reaction(RT-PCR) were used to detect the expression of MCP-1 protein and mRNA, respectively.RESULTS: The severity of corneal lesions in the rapamycin treatment group was reduced, and the clinical score of the slit lamp examination was lower than that of Groups B and C(P<0.01). The expression of MCP-1 in rapamycin treatment group was significantly inhibited, comparing to that of groups B and C(P<0.01).CONCLUSION: Liposome is a good drug carrier for rapamycin. Rapamycin has a good therapeutic effect on FK. It can reduce FK fungal burden and significantly inhibit the expression of MCP-1 protein and mRNA. 展开更多
关键词 fungal keratitis rapamycin liposome monocyte chemotactic protein-1 rats
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丙泊酚联合不同药物诱导全身麻醉在眼科手术中的效果比较 认领 引用 被引量：13
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作者 杨明 王淑珍 顾恩华 《中国现代医学杂志》 CAS 2018年第1期112-114,共3页
目的比较丙泊酚复合顺式阿曲库铵与丙泊酚复合去氧肾上腺素对于眼科手术患者全身麻醉诱导期间血流动力学及呼吸的影响。方法选择需在全身麻醉喉罩通气下行眼科手术的患者60例,采用随机数字表法分为两组,丙泊酚复合顺式阿曲库铵组(PC组)... 目的比较丙泊酚复合顺式阿曲库铵与丙泊酚复合去氧肾上腺素对于眼科手术患者全身麻醉诱导期间血流动力学及呼吸的影响。方法选择需在全身麻醉喉罩通气下行眼科手术的患者60例,采用随机数字表法分为两组,丙泊酚复合顺式阿曲库铵组(PC组)与丙泊酚复合去氧肾上腺素组(PP组),每组30例。PC组麻醉诱导:予咪达唑仑0.05 mg/kg,舒芬太尼0.20μg/kg,丙泊酚1.00 mg/kg,顺式阿曲库铵0.05 mg/kg;PP组麻醉诱导:予咪达唑仑0.05 mg/kg,舒芬太尼0.20μg/kg,丙泊酚2.00 mg/kg,去氧肾上腺素0.50 mg/kg;诱导完成后置入可弯曲喉罩;予丙泊酚4 mg/(kg·h),七氟烷2%新鲜气流量2 L/min麻醉维持。喉罩置入后若自主呼吸存在则保留自主呼吸;如不存在则辅助呼吸5 min,恢复自主呼吸后保留自主呼吸,不能恢复自主呼吸则改为控制呼吸。比较两组患者麻醉诱导前(T_0)、诱导后(T_1)、喉罩置入后(T_2)、喉罩置入后5 min(T_3)心率和血压的变化以及不同诱导方式对呼吸的影响。结果在T_0、T_1和T_2时两组患者的心率血压比较急,差异无统计学意义(P>0.05);T_3时两组患者心率、血压比较,差异有统计学意义(P<0.05),PC组患者的心率、血压高于PP组,PC组患者的心率、血压在T_3时高于T_2、T_1和T_0,PP组患者的心率、血压在T_3时低于T_2、T_1及T_0。PC组喉罩置入后5 min有16例患者自主呼吸不能恢复,需控制呼吸,PP组喉罩置入后5 min有1例患者自主呼吸不能恢复需控制呼吸,两组比较差异有统计学意义(P<0.05)。结论丙泊酚复合去氧肾上腺素进行麻醉诱导对于喉罩通气保留自主呼吸的全身麻醉患者血流动力学影响和呼吸抑制较小,是一种更好的选择。 展开更多
关键词 丙泊酚 顺式阿曲库铵 去氧肾上腺素 全身麻醉
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