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Exploiting neonatal host-bifidobacteria interactions to promote intestinal pathogen tolerance and barrier function:Bifidobacterium longum subsp.infantis outperforms Bifidobacterium adolescentis in anti-Salmonella activity and maintenance of intestinal hom 认领 引用
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作者 Chunxiu Lin Shunhe Wang +6 位作者 Min Guo Wentian Li Jiayin Qiu Yonghua Zhou Hao Zhang Wei Chen Gang Wang 《Food Science and Human Wellness》 SCIE CAS CSCD 2025年第4期1343-1359,共17页
Bifidobacterium longum subsp.infantis and Bifidobacterium adolescentis play important roles in the guts of infants and adolescents,respectively.In this study,using a neonatal rat model,we compared the protective effec... Bifidobacterium longum subsp.infantis and Bifidobacterium adolescentis play important roles in the guts of infants and adolescents,respectively.In this study,using a neonatal rat model,we compared the protective effects of these 2 bifidobacterial species against Salmonella infection.The results demonstrated that B.longum subsp.infantis was more effective than B.adolescentis in alleviating the severity of infection in newborn rats exposed to Salmonella enterica serovar Typhimurium strain SL1344.B.longum subsp.infantis attenuated intestinal inflammation and mucosal damage induced by Salmonella infection,as well as protecting intestinal nerves and intestinal barrier function through TLR4/My D88 signalling.B.longum subsp.infantis also displayed the potential to modulate gut metabolites by promoting the biosynthesis of unsaturated fatty acids(arachidonic acid,eicosapentaenoic acid andα-linolenic acid)and purine metabolism(guanine,adenine,inosine and adenosine),thereby regulating metabolic disturbances.Additionally,the benefits of B.longum subsp.infantis were also observed in the liver,spleen and brain,improving nerve reflexes and suppressing hepatosplenomegaly.Overall,these findings provide novel insights into the prevention and treatment of gutrelated diseases in newborns,highlighting the potentially significant role of B.longum subsp.infantis in clinical applications. 展开更多
关键词 Salmonella infection Bifidobacterium longum subsp.infantis Bifidobacterium adolescentis Newborn Intestinal inflammation
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Insights into the impact of Bifidobacterium bifidum,Bifidobacterium breve,and Bifidobacterium longum on the immune response against Salmonella infection in neonatal rats 认领 引用
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作者 Chunxiu Lin Yugui Lin +7 位作者 Min Guo Rui Xiao Shunhe Wang Yonghua Zhou Jianxin Zhao Hao Zhang Wei Chen Gang Wang 《Food Science and Human Wellness》 SCIE CAS CSCD 2025年第9期3487-3502,共16页
Infants exhibit diminished susceptibility to external infections,a phenomenon closely linked to the pervasive presence of the bifidobacterial community within their intestinal tract.Nonetheless,a significant knowledge... Infants exhibit diminished susceptibility to external infections,a phenomenon closely linked to the pervasive presence of the bifidobacterial community within their intestinal tract.Nonetheless,a significant knowledge gap remains concerning the distinct species of bifidobacteria initiating anti-infection immune responses during the early developmental stages.In this study,the impact of early intervention with Bifidobacterium bifidum,Bifidobacterium breve,and Bifidobacterium longum on neonatal rats infected with Salmonella enterica serovar Typhimurium SL1344 were compared.The study encompasses various immunity levels,including gut immunity,central immunity(thymus),peripheral immunity(spleen),and brain immunity.Following Salmonella infection,significant alterations in neonatal rats were observed in growth and developmental levels,immune markers,cytokine levels,balance of T lymphocyte subpopulations,intestinal barrier function,and blood-brain barrier integrity.Compared with B.breve and B.longum,B.bifidum demonstrated more pronounced efficacy in regulating these physiological processes.By conducting multi-level analyses of gut microbiota,bifidobacterial community,colonic content metabolomics,and serum metabolomics,the significance of B.bifidum’s role is underscored,and the immune-enhancing function of messenger metabolites is unveiled.Among these metabolites,γ-L-glutamyl-L-glutamic acid and orotic acid were found to be shared by all 3 species,while hippuric acid and 1a,1b-dihomo prostaglandin F2αwere unique to B.bifidum,and DL-arginine was specific to B.longum.Overall,this study has provided novel insights into the intervention and immunomodulation by Bifidobacterium in early-life infections,emphasizing the significant role of B.bifidum. 展开更多
关键词 Bifidobacterial community Salmonella infection Immune responses Neonatal rats Messenger metabolites
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MR imaging features of secondary breast lymphoma in a male patient:a case report and literature review 认领 引用 被引量：1
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作者 Zubin Ouyang Zhiwei Zhang +2 位作者 Jun Shi Shunhe Wang Guosheng Ren 《The Chinese-German Journal of Clinical Oncology》 2012年第6期361-364,共4页
We reported the rare case of an elderly man with secondary breast lymphoma （SBL） associated with magnetic resonance imaging findings. MR images demonstrated multiple well-defined masses in the left breast, with hete... We reported the rare case of an elderly man with secondary breast lymphoma （SBL） associated with magnetic resonance imaging findings. MR images demonstrated multiple well-defined masses in the left breast, with heterogeneous enhancement on dynamic contrast-enhanced sequences. The time signal-intensity curve rapidly increased during the initial rise phase and washed out during the delayed phase. The apparent diffusion coefficient （ADC） value was 0.649 x 104 mm2/s. Maximum intensity projection （MIP） showed that the masses were distributed in the upper outer quadrant, in the axillary region and in the lower outer region of the left chest wall. The pathology confirmed the diagnosis of non-Flodgkin＇s lymphoma. The combination of morphological and kinetic features, as well as a significantly lower ADC value, are helpful in the diagnosis of breast lymphoma and its differentiation from breast cancer. 展开更多
关键词 secondary breast lymphoma （SBL） magnetic resonance imaging （MRI） diffusion-weighted imaging （DWl） pathology
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Species-or genus-dependent immunostimulatory effects of gut-derived potential probiotics 认领 引用
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作者 Saisai Feng Shunhe Wang +7 位作者 Dingwu Qu Jing Li Fengwei Tian Leilei Yu Hao Zhang Jianxin Zhao Wei Chen Qixiao Zhai 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2023年第10期786-794,共9页
The immune regulatory effects of probiotics have been widely recognized to be strain-specific.However,it is unknown if there is a species-or genus-dependent manner.In this study,we use an in vitro mesenteric lymph nod... The immune regulatory effects of probiotics have been widely recognized to be strain-specific.However,it is unknown if there is a species-or genus-dependent manner.In this study,we use an in vitro mesenteric lymph node(MLN)model to systematically evaluate the immunostimulatory effects of gut-derived potential probiotics.The results exhibit an obvious species or genus consensus immune response pattern.RNA-seq shows that T cell-dependent B cell activation and antibody responses may be inherent to this model.Of the five tested genera,Akkermansia spp.and Clostridium butyrium directly activate the immune response in vitro,as indicated by the secretion of interleukin-10.Bifidobacterium spp.and Bacteroides spp.activate immune response with the help of stimuli(anti-CD3 and anti-CD28 antibodies).Lactobacillus spp.blunt the immune response with or without stimuli.Further investigations show that the cell surface protein of A.muciniphila AH39,which may serve as a T cell receptor cognate antigen,might evoke an in vitro immune activation.In vivo,oral administration of A.muciniphila AH39 influences the proportion of T regulatory cells(Tregs)in MLNs and the spleen under homeostasis in both specific pathogen-free and germ-free mice.All these findings indicate the distinct effects of different genera or species of potential gut-derived probiotics on intestinal and systemic immunity. 展开更多
关键词 Akkermansia muciniphila Clostridium butyricum Mesenteric lymph nodes In vitro model Species or genus responsive pattern
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Mechanism of synbiotic in alleviating inflammatory bowel disease:Gut microbiota metabolic pathways and treg differentiation 认领 引用
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作者 Shunhe Wang Leilei Yu +3 位作者 Fengwei Tian Jianxin Zhao Qixiao Zhai Wei Chen 《Food Bioscience》 SCIE 2025年第12期733-744,共12页
Ulcerative colitis(UC)is a chronic inflammatory bowel disease.This study explored the mechanisms of complex synbiotics in UC treatment using a DSS-induced colitis model.Interventions including different combinations o... Ulcerative colitis(UC)is a chronic inflammatory bowel disease.This study explored the mechanisms of complex synbiotics in UC treatment using a DSS-induced colitis model.Interventions including different combinations of synbiotics with types of probiotics,oligosaccharides,and plant extracts were used to research the synergistic therapeutic effect.All treatments alleviated colitis symptoms,with synbiotics showing superior efficacy over probiotics alone.All types of synbiotics modulated gut microbiota,increased short-chain fatty acids(SCFAs),induced Treg cell differentiation,promoted IL-10 and IL-22 expression,and inhibited TNF-αand IFN-γexpres-sion.Different types of synbiotics enhanced SCFA-producing bacteria and targeted distinct bacterial genera.Metabolic pathway analysis revealed that all types of synbiotics changed the metabolism of carbohydrate,amino acid,glycan,and fatty acid,which linked to SCFA production.Genomic analysis confirmed multiple carbohydrate-active enzymes(CAZymes)in probiotic strains,contributing to diverse SCFA profiles.These findings demonstrate that different types of synbiotic improve UC through microbiota metabolic pathway regulation and Treg differentiation modulation,providing a basis for the formulation of synbiotic in their therapeutic applications. 展开更多
关键词 Probiotic Synbiotic SCFA Gut microbiota metabolic pathways Treg differentiation
Natural aggregation of Lactobacillus:Mechanisms and influencing factors 认领 引用 被引量：6
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作者 Shunhe Wang Lulu Li +4 位作者 Leilei Yu Fengwei Tian Jianxin Zhao Qixiao Zhai Wei Chen 《Food Bioscience》 SCIE 2024年第6期94-113,共20页
Lactobacillus aggregation is a bacterial behavior,in which Lactobacillus cells adhere to each other or other strains to form aggregates.Substantial evidence indicates that Lactobacillus aggregation is closely related ... Lactobacillus aggregation is a bacterial behavior,in which Lactobacillus cells adhere to each other or other strains to form aggregates.Substantial evidence indicates that Lactobacillus aggregation is closely related to biofilm formation,adhesion,colonization,and host physiological functions.Current reviews on Lactobacillus aggregation are often limited to a few aspects,or serve as a single step to address other related problems.In this paper,we review the current state and characteristics of self-and co-aggregations,including aggregation percentages,influencing factors,molecular mechanisms,and functions.Lactobacillus aggregation is a strain-specific behavior,rather than a species-specific one,and the characteristics of both aggregations are similar.The same species of Lactobacillus exhibits a relatively broad range of aggregation percentage,and involved in different influencing factors and mechanisms.Moreover,the same factors and mechanisms also participate in different Lactobacillus aggregations.This is mainly because of the complexity of aggregations.Meanwhile,we also summarize the functions of aggregation,including enhancing bacterial survival,promoting biofilm formation and involving in host physiological regulation. 展开更多
关键词 Aggregation Lactobacillus Molecular mechanisms Influencing factors
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