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Rhein/Fe3+nanoassembly for triple-negative breast cancer treatment via a ferroptosis and immunogenic death 认领 引用
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作者 Shuntao Liang Licheng Gan +10 位作者 Xiaomei Tao Fei Xia Qingchao Tu Linying Zhong Yuanfeng Fu Yinan Liu Yuqing Meng Qiaoli Shi Junzhe Zhang Jigang Wang Chong Qiu 《Chinese Herbal Medicines》 CAS CSCD 2026年第2期481-483,共3页
To the Editor:Triple-negative breast cancer(TNBC)remains one of the most formidable clinical challenges in oncology.Due to the absence of estrogen receptor,progesterone receptor,and human epidermal growth factor recep... To the Editor:Triple-negative breast cancer(TNBC)remains one of the most formidable clinical challenges in oncology.Due to the absence of estrogen receptor,progesterone receptor,and human epidermal growth factor receptor(HER2)expression,TNBC is intrinsically insensitive to endocrine therapies and HER2-targeted agents.Although immune checkpoint blockade(ICB)has transformed cancer therapy,its efficacy in TNBC is often limited by an“immune-cold”microenvironment characterized by scarce tumor-infiltrating lymphocytes and dominant immunosuppressive(Keenan&Tolaney,2020). 展开更多
关键词 Rhein triple negative breast cancer ferroptosis endocrine therapies human epidermal growth factor Fe immunogenic death immune checkpoint blockade icb
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