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SlWRKY80 and SlWRKY81 synergistically regulate the autophagy gene SlATG13b to actively resist saline-alkali stress in tomato 认领 引用
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作者 Chunyu Shang Guo Chen +12 位作者 Xianjue Ruan Xiaoyan Liu Dan Du Xin Hu Zhenglun Li Qingyuan Li Xinchen Niu Dongdong Gao Silong Li Abid Khan Jinhua Li Yu Pan Xiaohui Hu 《Horticultural Plant Journal》 SCIE CAS CSCD 2026年第4期905-917,共13页
Saline-alkali stress is a significant abiotic stressor that affects the growth of tomato(Solanum lycopersicum L.).Our previous studies reported that the homologous genes SIWRKY80 and SIWRKY81 can both resist saline-al... Saline-alkali stress is a significant abiotic stressor that affects the growth of tomato(Solanum lycopersicum L.).Our previous studies reported that the homologous genes SIWRKY80 and SIWRKY81 can both resist saline-alkali stress by mediating the JA pathway.In this study,the cooverexpressing(SOE)and co-silencing(SQ)lines of SlWRKY80 and SIWRKY81 to saline-alkali treatment,and the results showed that SOE line had significantly higher morphological indices,physiological indices,and endogenous JA and MeJA contents than the WT,while SQ line was opposite.In addition,the SOE line showed a significant increase in autophagy against saline-alkali stress,and both SlWRKY80 and SlWRKY81 were positively regulating the transcription of the autophagy gene SIATG13b as screened and verified by transcriptome screening,qRT-PCR,WB(Western Blot),Y1H(Yeast One-Hybrid),ChIP-qPCR,EMSA(Electrophoretic Mobility Shift Assay),and D-LUC(D-Luciferin Experiment),and also had a synergistic effect in activating SIATG13b.The growth and physiological indexes of VIGS-SIATG13b line were significantly lower than those of other groups,and pro-SlATG13b is significantly activated by MeJA and saline-alkali signals,so the SIATG13b was regulating the resistance of tomato to saline-alkali stress.In summary,the increase of endogenous JA and MeJA content in tomato after saline-alkali stress inhibited the expression and synthesis of SIJAZ1,activated the transcription and protein synthesis of SlWRKY80 and SlWRKY81,and SlWRKY80 and SlWRKY81 coordinately regulated the transcription of SlATG13b,which resulted in the production of more autophagosomes and enhanced the resistance of tomato to saline-alkali stress.This study further improved the molecular mechanism of SlWRKY80 and SIWRKY81 mediating the JA pathway against saline-alkali stress,and laid a solid theoretical foundation for tomato saline-alkali resistance breeding. 展开更多
关键词 SlWRKY80 SlWRKY81 SlATG13b Autophagy Saline-alkali stress
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Exploring the Mechanism of Wumei Pill in the Treatment of Autoimmune Hepatitis Based on Network Pharmacology and Molecular Docking 认领 引用
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作者 Xinyue Shangguan Shuangyue Wen +4 位作者 Silong Li Chuyu Dong Ruiyun Wang Buyue Zhang He Zhang 《Journal of Clinical and Nursing Research》 2025年第12期313-322,共10页
Objective:To explore the molecular mechanism and action pathways of Wumei Pill in the treatment of autoimmune hepatitis(AIH)using network pharmacology and molecular docking methods.Methods:The active components and ta... Objective:To explore the molecular mechanism and action pathways of Wumei Pill in the treatment of autoimmune hepatitis(AIH)using network pharmacology and molecular docking methods.Methods:The active components and targets of Wumei Pill,as well as AIH-related disease targets,were screened through the TCMSP,GeneCards,OMIM,and Disgenet databases.Cytoscape 3.9.1 was used to construct a series of topological networks,followed by Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis and Gene Ontology(GO)enrichment analysis.Molecular docking and visualization were performed using AutoDockTools 1.5.7 and PyMOL 2.4.0.Results:A total of 124 active components of Wumei Pill,877 drug targets,1130 disease targets,and 64 overlapping targets were obtained.GO enrichment analysis yielded 82 biological processes,4 cellular components,and 19 molecular functions.KEGG pathway enrichment analysis identified 21 signaling pathways.Conclusion:Wumei Pill can act on targets such as Tumor Necrosis Factor(TNF),Caspase 3(CASP3),C-X-C Motif Chemokine Ligand 8(CXCL8),Nuclear Factor Kappa B Subunit 1(NFKB1),and Transforming Growth Factor Beta 1(TGFB1)through active components including girinimbine and(R)-tetrahydroberberine.It further regulates inflammation and apoptosis-related pathways such as tumorrelated signaling pathways and Th17 cell differentiation pathway to treat AIH.This study provides a theoretical basis for in-depth research on the mechanism of Wumei Pill in the treatment of AIH and the development of therapeutic drugs. 展开更多
关键词 Wumei pill Autoimmune hepatitis(AIH) Network pharmacology Molecular docking technology
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超交联多孔材料的合成及吸附氨基酸特性 认领 引用 被引量：1
3
作者 闫慧君 高飞翔 +5 位作者 王爽 李思龙 高锦鹏 李姗姗 王楷淞 白建伟 《高分子材料科学与工程》 EI CAS CSCD 北大核心 2023年第6期1-7,14,共7页
以苯为反应单体、二甲氧基甲烷(FDA)为交联剂,通过Friedel-Crafts烷基化反应,改变单体与交联剂之间的摩尔比来调控聚合物的孔隙结构,合成了一系列具有高比表面积的多孔芳香交联聚合物HCP-PhH-(1-3)。通过氮气吸附脱附、热失重和红外光... 以苯为反应单体、二甲氧基甲烷(FDA)为交联剂,通过Friedel-Crafts烷基化反应,改变单体与交联剂之间的摩尔比来调控聚合物的孔隙结构,合成了一系列具有高比表面积的多孔芳香交联聚合物HCP-PhH-(1-3)。通过氮气吸附脱附、热失重和红外光谱对其进行表征,聚合物表现出丰富的孔径结构与良好的稳定性。将其对色氨酸(Trp)、苯丙氨酸(Phe)以及苯甘氨酸(Phg)进行了吸附行为研究,结果表明,单体苯与交联剂FDA的摩尔比为1:5时,合成的聚合物HCP-PhH-3具有相对较大的比表面积901.498 m2/g,在25℃时对pH=7、浓度1.5 mmol/L的氨基酸溶液具有较大的吸附能力,吸附量分别为色氨酸(0.199 mmol/g)、苯丙氨酸(0.140mmol/g)、苯甘氨酸(0.034 mmol/g),显示出明显的吸附效果。对HCP-PhH-3吸附氨基酸的过程进行动力学拟合,线性拟合相关度(R2)符合准二级动力学模型。 展开更多
关键词 超交联 外交联编织 多孔材料 氨基酸吸附
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