Field-assisted diamond cutting technology is a significant machining method that utilizes external energy fields to enhance the manufacturing performance.However,aimed the emergence of advanced high-performance materi...Field-assisted diamond cutting technology is a significant machining method that utilizes external energy fields to enhance the manufacturing performance.However,aimed the emergence of advanced high-performance materials,traditional single-field-assisted machining struggles to meet stringent precision requirements.Therefore,this study introduces an innovative and unique multi-energy field-assisted ultra-precision machining technology,in-situ laser-magnetic dual-field assisted diamond cutting(LMDFDC),to transcend the limitations of conventional single-field-assisted cutting methods and advance the machinability of challenging materials,notably the multi-principal-element high-entropy alloy(HEA).To elucidate the fundamental science questions of“what occurs,what changes,and what improves”in this work,the phenomenological behaviors of the dual-field coupling interaction are systematically investigated through advanced characterization techniques,spanning macroscopic surface integrity to microscopic atomic arrangement.This comprehensive study encompasses integrated analyses of four machining techniques for HEA workpiece,namely dual-energy field,two single-energy fields,and no-energy field.The research results indicate that the dual-field coupling effect demonstrates a leap in manufacturing performance through thermo-magneto-mechanical multi-physical synergistic interactions,primarily manifested in improved surface quality,reduced subsurface damage,suppressed diamond tool wear,and enhanced material removal stability.The significance of in-situ LMDFDC technology resides in propelling frontier academic developments in multi-physics coupled manufacturing theories while uncovering innovative machining approaches for next-generation high-performance materials.展开更多
The corrosion and passive behavior of HP-13Cr stainless steel(HP-13Cr SS)in formate annulus protection fluid was investigated.HP-13Cr SS exhibited good passive behavior in clean formate annulus protection fluid,which ...The corrosion and passive behavior of HP-13Cr stainless steel(HP-13Cr SS)in formate annulus protection fluid was investigated.HP-13Cr SS exhibited good passive behavior in clean formate annulus protection fluid,which was attributed to a thinner and more dense passive film mainly composed of Cr2O3.In the formation water solution,the passive film was composed of metastable Cr(OH)3,which was explained by the isoelectric point theory,resulting in the deterioration of the passive behavior of HP-13Cr SS.When the formation water penetrated the formate annulus protection fluid,a large number of loose FeCO3particles formed in the corrosion scales,thus HP-13Cr SS suffered severe corrosion.Therefore,avoiding formation water penetrating the formate annulus protection fluid is conducive to improving the service life of HP-13Cr SS oil tubes in extremely aggressive environment.展开更多
To the Editor:Gastric cancer(GC)poses a great threat to human health worldwide.N6-methyladenosine(m6A)RNA methylation,the most abundant post-transcriptional RNA modification,plays a crucial role in RNA splicing,export...To the Editor:Gastric cancer(GC)poses a great threat to human health worldwide.N6-methyladenosine(m6A)RNA methylation,the most abundant post-transcriptional RNA modification,plays a crucial role in RNA splicing,export,processing,translation,and decay.ii The tumor microenvironment(TME),an aggregation of tumor cells and surrounding tumor-related non-tumor cells,innately modulates tumor progression,21However,the prognostic value of m6A regulator-related genes and their relationship with the TME have not been largely explored in GC.The aim of our study was to screen prognostic genes related to m6A modification in GC patients in The Cancer Genome Atlas(TCGA)database,establish an m6A regulatorassociated signature for predicting clinical outcome,and validate the performance in TCGA and Gene Expression Omnibus(GEO)cohorts.The relationship between m6A and immune infiltration was also assessed in GC.With the underlyingmechanismuncovered,m6A-relatedgenescould become predictive biomarkers for GC and provide deeper insights into the TME and immunotherapy.展开更多
基金partially supported by the General Research Funds from the Research Grants Council of the Hong Kong Special Administrative Region(HKSAR),China(Project Nos.:PolyU 15221322 and PolyU 15206824)Mainland-Hong Kong Joint Funding Scheme(MHKJFS)from Innovation and Technology Commission(ITC)of the Government of HKSAR(Project No.:MHP/051/22)+2 种基金The Special Funding for Jiangsu Province Innovation Support Program under Grant(BZ2023058)The authors would also like to express their sincere gratitude to the support from the State Key Laboratories in Hong Kong from the ITC of the Government of HKSARthe Research and Innovation Office of The Hong Kong Polytechnic University.
摘要Field-assisted diamond cutting technology is a significant machining method that utilizes external energy fields to enhance the manufacturing performance.However,aimed the emergence of advanced high-performance materials,traditional single-field-assisted machining struggles to meet stringent precision requirements.Therefore,this study introduces an innovative and unique multi-energy field-assisted ultra-precision machining technology,in-situ laser-magnetic dual-field assisted diamond cutting(LMDFDC),to transcend the limitations of conventional single-field-assisted cutting methods and advance the machinability of challenging materials,notably the multi-principal-element high-entropy alloy(HEA).To elucidate the fundamental science questions of“what occurs,what changes,and what improves”in this work,the phenomenological behaviors of the dual-field coupling interaction are systematically investigated through advanced characterization techniques,spanning macroscopic surface integrity to microscopic atomic arrangement.This comprehensive study encompasses integrated analyses of four machining techniques for HEA workpiece,namely dual-energy field,two single-energy fields,and no-energy field.The research results indicate that the dual-field coupling effect demonstrates a leap in manufacturing performance through thermo-magneto-mechanical multi-physical synergistic interactions,primarily manifested in improved surface quality,reduced subsurface damage,suppressed diamond tool wear,and enhanced material removal stability.The significance of in-situ LMDFDC technology resides in propelling frontier academic developments in multi-physics coupled manufacturing theories while uncovering innovative machining approaches for next-generation high-performance materials.
基金supported by the Youth Program of the National Natural Science Foundation of China(No.52001061)the Young Elite Scientist Sponsorship Program Cast(No.YESS20200139)the Fundamental Research Funds for the Central Universities(No.N2202016).
摘要The corrosion and passive behavior of HP-13Cr stainless steel(HP-13Cr SS)in formate annulus protection fluid was investigated.HP-13Cr SS exhibited good passive behavior in clean formate annulus protection fluid,which was attributed to a thinner and more dense passive film mainly composed of Cr2O3.In the formation water solution,the passive film was composed of metastable Cr(OH)3,which was explained by the isoelectric point theory,resulting in the deterioration of the passive behavior of HP-13Cr SS.When the formation water penetrated the formate annulus protection fluid,a large number of loose FeCO3particles formed in the corrosion scales,thus HP-13Cr SS suffered severe corrosion.Therefore,avoiding formation water penetrating the formate annulus protection fluid is conducive to improving the service life of HP-13Cr SS oil tubes in extremely aggressive environment.
基金National Key Development Plan for Precision Medicine Research(No.2017YFC 0910002)。
摘要To the Editor:Gastric cancer(GC)poses a great threat to human health worldwide.N6-methyladenosine(m6A)RNA methylation,the most abundant post-transcriptional RNA modification,plays a crucial role in RNA splicing,export,processing,translation,and decay.ii The tumor microenvironment(TME),an aggregation of tumor cells and surrounding tumor-related non-tumor cells,innately modulates tumor progression,21However,the prognostic value of m6A regulator-related genes and their relationship with the TME have not been largely explored in GC.The aim of our study was to screen prognostic genes related to m6A modification in GC patients in The Cancer Genome Atlas(TCGA)database,establish an m6A regulatorassociated signature for predicting clinical outcome,and validate the performance in TCGA and Gene Expression Omnibus(GEO)cohorts.The relationship between m6A and immune infiltration was also assessed in GC.With the underlyingmechanismuncovered,m6A-relatedgenescould become predictive biomarkers for GC and provide deeper insights into the TME and immunotherapy.