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Advances in the study of senegenin in vascular cognitive impairment 认领 引用
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作者 Yu-Tao Lu Yuan-Yuan Xiang +5 位作者 Zi-Xuan Wang Tian-Rui Yu Ling He Xian-Ming Cao Xiao-Ping Yin Zhi-Ying Chen 《Traditional Medicine Research》 2026年第7期49-59,共11页
Vascular cognitive impairment(VCI)denotes a condition marked by parenchymal brain damage resulting from vascular issues,ultimately culminating in cognitive deterioration that spans from mild cognitive impairment to va... Vascular cognitive impairment(VCI)denotes a condition marked by parenchymal brain damage resulting from vascular issues,ultimately culminating in cognitive deterioration that spans from mild cognitive impairment to vascular dementia.Senegenin is a saponin extract obtained from Polygala tenuifolia,a traditional Chinese medicinal herb known for its significant neuroprotective properties.The review analyzes the impact of senegenin on VCI from the viewpoints of traditional Chinese medicine(TCM)and contemporary medical practices.From the standpoint of TCM,we examine three notable traditional Chinese medicine formulations:Kaixin San,Dingzhi Xiaowan,and Smart Soup.We extensively examine the neuroprotective effects,antioxidant capabilities,and anti-inflammatory actions of senegenin from a contemporary medical standpoint.Additionally,we perform a retrospective review of the extraction and formulation techniques of senegenin.The aim of this review is to summarize the particular mechanisms of senegenin’s multi-targeting and to offer novel insights into clinical therapy strategies for VCI. 展开更多
关键词 Senegenin vascular cognitive impairment vascular dementia Polygala tenuifolia traditional Chinese medicine modern medicine
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