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Clinical guidelines on physical activity and exercise therapy for Chinese adults with type 2 diabetes:A clinical practice guideline from the Chinese Society of Endocrinology 认领 引用 被引量：1
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作者 Fang Zhang Jiajun Zhao +9 位作者 Yuwei Zhang Zhenjun Tian Jing Li Qingguo Lv Weiqing Wang Tianpei Hong Zhongyan Shan Li Yan Yongde Peng Nanwei Tong 《Journal of Sport and Health Science》 SCIE CAS CSCD 2026年第5期44-76,共33页
Diabetes,a leading global chronic disease,poses a significant health threat,with physical inactivity being a major risk factor for its development and progression.This guideline,developed by the Chinese Society of End... Diabetes,a leading global chronic disease,poses a significant health threat,with physical inactivity being a major risk factor for its development and progression.This guideline,developed by the Chinese Society of Endocrinology,synthesizes the latest evidence and expert insights to provide evidence-based recommendations for physical activity and exercise therapy in adults with type 2 diabetes(T2D).It is generally recommended that all adult patients with T2D engage in at least 150—300 min of moderate-intensity aerobic exercise per week,or a minimum of75—150 min of vigorous-intensity exercise,or an equivalent combination of moderate-and vigorous-intensity exercise(with a total exercise volume of at least 450 metabolic equivalent-min per week).For patients with T2D who are capable,moderate over-exercise and a combination of different forms of exercise(aerobic,resistance,flexibility,and/or balance training)are encouraged.The guideline also underscores the necessity of targeting specific subgroups of patients with T2D,including the elderly,individuals with obesity or pre-obesity,cardiovascular disease,hypertension,chronic kidney disease,metabolic dysfunction-associated steatotic liver disease,and/or diabetic foot and its high-risk populations.The guideline provides a scientific basis for clinicians to develop personalized exercise guidance and recommendations,with the goal of improving the disease prognosis of the relevant population. 展开更多
关键词 Adult Exercise Physical activity Type 2 diabetes Therapy principle
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Is the C677T polymorphism in methylenetetrahydrofolate reductase gene or plasma homocysteine a risk factor for diabetic peripheral neuropathy in Chinese individuals? 认领 引用 被引量：2
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作者 Hongli Wang Dongsheng Fan Tianpei Hong 《Neural Regeneration Research》 SCIE CAS CSCD 2012年第30期2384-2391,共8页
The present study enrolled 251 diabetic patients,including 101 with neuropathy and 150 without neuropathy.Of the 150 patients,100 had no complications,such as retinopathy,nephropathy,or neuropathy.Polymerase chain rea... The present study enrolled 251 diabetic patients,including 101 with neuropathy and 150 without neuropathy.Of the 150 patients,100 had no complications,such as retinopathy,nephropathy,or neuropathy.Polymerase chain reaction-restriction fragment length polymorphism analysis was used to identify methylenetetrahydrofolate reductase gene variants.Plasma homocysteine levels were also measured.Homocysteine levels and the frequency of hyperhomocysteinemia were significantly higher in patients with diabetic peripheral neuropathy compared with diabetic patients without neuropathy(P〈0.05).In logistic regression analysis with neuropathy as the dependent variable,the frequency of C677T in methylenetetrahydrofolate reductase was significantly higher in patients with diabetic peripheral neuropathy compared with patients without diabetic complications.Homocysteine levels were significantly higher in patients with diabetic peripheral neuropathy carrying the 677T allele and low folic acid levels.In conclusion,hyperhomocysteinemia is an independent risk factor for diabetic neuropathy in Chinese patients with diabetes.The C677T polymorphism in methylenetetrahydrofolate reductase and low folic acid levels may be risk factors for diabetic peripheral neuropathy in Chinese patients with diabetes. 展开更多
关键词 homocysteine methylenetetrahydrofolate reductase type 2 diabetes mellitus diabetic peripheralneuropathy neural regeneration
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Sodium-glucose cotransporter 2 inhibitors facilitate cell phenotype conversion of alpha cells through progenitors to beta cells by activating Ppargc1α in diabetic mice 认领 引用
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作者 Yafei Jiang Dandan Wang +6 位作者 Ming Tao Xiaona Cui Jian Li Tianjiao Wei Jin Yang Tianpei Hong Rui Wei 《Chinese Medical Journal》 SCIE CAS CSCD 2026年第6期906-919,共14页
Background:Sodium-glucose cotransporter 2 inhibitor(SGLT2i)improves beta-cell function in animals and humans with diabetes.Herein,we aimed to investigate the effects of SGLT2i on beta-cell regeneration,trace the origi... Background:Sodium-glucose cotransporter 2 inhibitor(SGLT2i)improves beta-cell function in animals and humans with diabetes.Herein,we aimed to investigate the effects of SGLT2i on beta-cell regeneration,trace the origin of regenerated beta cells,and reveal the potential mechanism.Methods:Type 2 and type 1 diabetic mice were treated with canagliflozin(10 mg/kg),dapagliflozin(1 mg/kg),or vehicle.Islet morphology was evaluated to investigate beta-cell regeneration.Inducible pancreatic neurogenin 3(Ngn3)+progenitor lineage-tracing mice and alpha-cell lineage-tracing mice were used to trace the origin of regenerated cells.Mouse and human islets,alpha cells,and beta cells were incubated with dapagliflozin(12.5μmol/L)or vehicle.Insulin and glucagon-like peptide-1(GLP-1)release,gene expression,and RNA sequencing analysis were performed to clarify the direct actions of SGLT2i and to screen potential targets.Alpha cells were transfected with peroxisome proliferator-activated receptor-γcoactivator 1α(Ppargc1α)plasmid or with Ppargc1αsiRNA,followed by incubation with or without dapagliflozin to confirm the effects of Ppargc1αin alpha-cell phenotype conversion.Results:SGLT2i increased islet and beta-cell areas in type 2 diabetic mice and showed a similar trend in type 1 diabetic mice.SGLT2i induced alpha-cell dedifferentiation into Ngn3+ progenitors and promoted progenitor differentiation toward beta cells.In cultured diabetic mouse and human islets and in stressed alpha cells,SGLT2i increased supernatant insulin and active GLP-1 levels,downregulated alpha-cell-specific marker expression,and upregulated the expression of endocrine progenitor-and betacell-specific markers,including prohormone convertase 1/3.Although dapagliflozin did not affect beta cells directly,it affected alpha cells(457 upregulated and 235 downregulated genes).Ppargc1α,a coactivator participating in oxidative phosphorylation,was identified as a potential target.By using overexpression and knockdown,we confirmed that Ppargc1αparticipated in SGLT2i-induced regulation of alpha-cell phenotype conversion.Conclusion:Alpha-cell regression to progenitors and progenitor differentiation toward beta cells represent a novel pathway for beta-cell neogenesis induced by SGLT2i in diabetes,with Ppargc1αplaying a role in this process. 展开更多
关键词 Alpha cells Beta-cell regeneration Diabetes Peroxisome proliferator-activated receptor-γcoactivator 1α Sodiumglucose cotransporter 2 inhibitor
Identification of key genes and pathways in mild and severe nonalcoholic fatty liver disease by integrative analysis 认领 引用 被引量：1
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作者 Jin Feng Tianjiao Wei +2 位作者 Xiaona Cui Rui Wei Tianpei Hong 《Chronic Diseases and Translational Medicine》 CAS CSCD 2021年第4期276-286,共11页
Background:The global prevalence of nonalcoholic fatty liver disease(NAFLD)is increasing.The pathogenesis of NAFLD is multifaceted,and the underlying mechanisms are elusive.We conducted data mining analysis to gain a ... Background:The global prevalence of nonalcoholic fatty liver disease(NAFLD)is increasing.The pathogenesis of NAFLD is multifaceted,and the underlying mechanisms are elusive.We conducted data mining analysis to gain a better insight into the disease and to identify the hub genes associated with the progression of NAFLD.Methods:The dataset GSE49541,containing the profile of 40 samples representing mild stages of NAFLD and 32 samples representing advanced stages of NAFLD,was acquired from the Gene Expression Omnibus database.Differentially expressed genes(DEGs)were identified using the R programming language.The Database for Annotation,Visualization and Integrated Discovery(DAVID)online tool and Search Tool for the Retrieval of Interacting Genes/Proteins(STRING)database were used to perform the enrichment analysis and construct protein-protein interaction(PPI)networks,respectively.Subsequently,transcription factor networks and key modules were identified.The hub genes were validated in a mice model of high fat diet(HFD)-induced NAFLD and in cultured HepG2 cells by real-time quantitative PCR.Results:Based on the GSE49541 dataset,57 DEGs were selected and enriched in chemokine activity and cellular component,including the extracellular region.Twelve transcription factors associated with DEGs were indicated from PPI analysis.Upregulated expression of five hub genes(SOX9,CCL20,CXCL1,CD24,andCHST4),which were identified from the dataset,was also observed in the livers of HFD-induced NAFLD mice and in HepG2 cells exposed to palmitic acid or advanced glycation end products.Conclusion:The hub genesSOX9,CCL20,CXCL1,CD24,andCHST4 are involved in the aggravation of NAFLD.Our results offer new insights into the underlying mechanism of NAFLD progression. 展开更多
关键词 Nonalcoholic fatty liver disease Fatty liver Computational biology
Regeneration of β cells from cell phenotype conversion among the pancreatic endocrine cells 认领 引用
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作者 Tianjiao Wei Rui Wei Tianpei Hong 《Chronic Diseases and Translational Medicine》 CAS CSCD 2022年第1期1-4,共4页
The prevalence of diabetes has increased dramatically, with over 537 million adults affected worldwide.1 In both type 1 and type 2 diabetes, pancreatic islet β cell dysfunction is common pathogenesis.
关键词 cell trans-differentiation endocrine pancreas βcell dedifferentiation βcell regeneration
Cardiovascular risk profile and clinical characteristics of diabetic patients:a cross-sectional study in China 认领 引用 被引量：3
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作者 Fang Lyu Xiaoling Cai +8 位作者 Chu Lin Tianpei Hong Xiaomei Zhang Juming Lu Xiaohui Guo Zhufeng Wang Huifang Xing Guizhi Zong Linong Ji 《Chinese Medical Journal》 SCIE CAS CSCD 2022年第3期295-300,共6页
Background:Cardiovascular(CV)disease is the leading cause of morbidity and mortality in adults with type 2 diabetes(T2D).The aim of this study was to determine the CV risk in Chinese patients with T2D based on the 201... Background:Cardiovascular(CV)disease is the leading cause of morbidity and mortality in adults with type 2 diabetes(T2D).The aim of this study was to determine the CV risk in Chinese patients with T2D based on the 2019 European Society of Cardiology(ESC)and the European Association for the Study of Diabetes(EASD)guidelines on diabetes,pre-diabetes,and CV diseases.Methods:A total of 25,411 patients with T2D,who participated in the study of China Cardiometabolic Registries 3B study,were included in our analysis.We assessed the proportions of patients in each CV risk category according to 2019 ESC/EASD guidelines.Results:Based on the 2019 ESC/EASD guidelines,16,663(65.6%),1895(7.5%),and 152(0.6%)of patients were included in"very high risk,""high risk,"and"moderate risk"categories,respectively.The proportions of patients in each category varied based on age,sex,body mass index,and duration.While 58.7%(9786/16,663)of elderly patients were classified to"very high risk"group,89.6%(3732/4165)of patients with obesity were divided into"very high risk"group.Almost all patients with a duration of diabetes>10 years had"very high risk"or"high risk."However,6701(26.4%)of Chinese T2D patients,who had shorter duration,and one or two risk factors,could not be included in any category(the"unclear risk"category).Conclusions:In China,most patients with T2D have"very high"or"high"CV risk based on 2019 ESC/EASD guidelines.However,the risk of patients in"unclear risk"group needs to be further classified. 展开更多
关键词 Cardiovascular risk Type 2 diabetes 2019 ESC/EASD guidelines
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