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Dissecting the natural and human drivers of urban thermal resilience across climates 认领 引用
1
作者 Renlu Qiao Tao Wu +10 位作者 Zexu Zhao Shuo Gao Ting Yang Chenyang Duan Shiqi Zhou Xiaochang Liu Li Xia Xi Meng Lei Jin Zhiyu Liu Zhiqiang Wu 《Geography and Sustainability》 CSCD 2025年第3期146-159,共14页
In the context of current global warming,understanding urban thermal resilience(UTR)dynamics across dif-ferent climatic zones is crucial.This study aims to examine the complex interactions among urban morphology,green... In the context of current global warming,understanding urban thermal resilience(UTR)dynamics across dif-ferent climatic zones is crucial.This study aims to examine the complex interactions among urban morphology,green-blue infrastructure,and climate factors affecting UTR.Moving beyond traditional methods that compare urban and rural thermal differences,our research innovatively measures UTR by evaluating urban disturbances caused by extreme thermal events.To improve accuracy and reliability,we utilize an AI-powered Monte Carlo Simulation framework.Our findings emphasize the critical role of blue-green spaces in boosting UTR,whereas urban morphology often has a suppressive impact.Additionally,atmospheric humidity is identified as a critical factor affecting UTR.The study interestingly finds varied climatic responses:dense urban areas enhance resilience in arid and cold regions but reduce it in tropical and temperate zones.These findings highlight the need for a balance between sustainable urban living and infrastructure development. 展开更多
关键词 Urban thermal resilience Extreme heat events Climatic heterogeneity Green-blue factors Urban morphology
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Interpreting hourly mass concentrations of PM2.5chemical components with an optimal deep-learning model 认领 引用 被引量：1
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作者 Hongyi Li Ting Yang +2 位作者 Yiming Du Yining Tan Zifa Wang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2025年第5期125-139,共15页
PM2.5constitutes a complex and diversemixture that significantly impacts the environment,human health,and climate change.However,existing observation and numerical simulation techniques have limitations,such as a l... PM2.5constitutes a complex and diversemixture that significantly impacts the environment,human health,and climate change.However,existing observation and numerical simulation techniques have limitations,such as a lack of data,high acquisition costs,andmultiple uncertainties.These limitations hinder the acquisition of comprehensive information on PM2.5chemical composition and effectively implement refined air pollution protection and control strategies.In this study,we developed an optimal deep learning model to acquire hourly mass concentrations of key PM2.5chemical components without complex chemical analysis.The model was trained using a randomly partitioned multivariate dataset arranged in chronological order,including atmospheric state indicators,which previous studies did not consider.Our results showed that the correlation coefficients of key chemical components were no less than 0.96,and the root mean square errors ranged from 0.20 to 2.11μg/m3for the entire process(training and testing combined).The model accurately captured the temporal characteristics of key chemical components,outperforming typical machine-learning models,previous studies,and global reanalysis datasets(such asModern-Era Retrospective analysis for Research and Applications,Version 2(MERRA-2)and Copernicus Atmosphere Monitoring Service ReAnalysis(CAMSRA)).We also quantified the feature importance using the random forest model,which showed that PM2.5,PM1,visibility,and temperature were the most influential variables for key chemical components.In conclusion,this study presents a practical approach to accurately obtain chemical composition information that can contribute to filling missing data,improved air pollution monitoring and source identification.This approach has the potential to enhance air pollution control strategies and promote public health and environmental sustainability. 展开更多
关键词 Pm2.5 chemical composition Hourly mass concentration Deep learning Bayesian optimization Feature importance
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Scalable,binder-free,ultrathin,and outdoor stable passive cooling paints engineered by cellulose-weaved topological scattering network 认领 引用 被引量：1
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作者 Ting Yang Siying Guo +5 位作者 Xin Zhao Bianjing Sun Ruey Shan Chen Sinyee Gan Jonathan Woon-Chung Wong Chenyang Cai 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第4期584-594,I0015,共11页
Paints with passive daytime radiative cooling capability hold significant promise for energy-efficient buildings owing to their ease of processing.However,conventional radiative cooling paints require substantial thic... Paints with passive daytime radiative cooling capability hold significant promise for energy-efficient buildings owing to their ease of processing.However,conventional radiative cooling paints require substantial thickness to achieve effective outdoor cooling and must be combined with binders to enhance adhesion to the substrate.Meanwhile,their long-term outdoor durability remains poor.In this work,we proposed a scattering network-enhanced ultrathin photonic cooling paint(thickness of 78μm)fabricated without traditional binders through a universal,scalable solution-assembly strategy under a low-carbon production process.Cellulose nanofiber and cellulose nanocrystal were employed to wrap and entangle TiO2,forming a topological scattering network that prevents near-field coupling.Together with hierarchical pores,this structure enables high solar reflectance(96.4%)and an infrared emissivity of 0.94.This novel paint achieves temperature reduction of~5.6 and 3.8℃ under low and high-humidity conditions of midday,respectively,while maintaining long-term outdoor stability.Importantly,the cellulose-weaved topological scattering network can also be engineered with alternative photonic cooling pigments(Al2O3,SiO2,BaSO4,and mica),demonstrating its universality.In addition,life cycle assessment reveals that the obtained cooling paint offers very low carbon emissions and minimal environmental impacts.This work provides an economically viable and environmentally sustainable alternative to existing passive cooling materials. 展开更多
关键词 Weaved network Radiative cooling Cellulose Ultrathin structure
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tDCS improves early Alzheimer’s disease by synaptic vesicle fusion and release 认领 引用
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作者 Yue-Yang Zhuang Jia-Min Yan +20 位作者 Tie-Cheng Wu Wen-Shan Xu Bao Wu Xi Xie Wen-Ju Wang Hua-Wei Lin Jia-Wei Jian Jun-Zi Wang Tao Jiang Li-Ming Chen Yu-Xi Qiu Zhong-Yi Hu Yi-Hui Zhou Ting Yang Min-Guang Yang Jing-Fang Zhu Jing Tao Li-Dian Chen Wei-Guang Li Kai Yan Wei-Lin Liu 《Military Medical Research》 SCIE CAS CSCD 2026年第4期606-628,共23页
Background:Working memory deficits,one of the earliest hallmarks of Alzheimer’s disease(AD),are closely linked to abnormal neural activity in the dorsolateral prefrontal cortex(DLPFC).Transcranial direct current stim... Background:Working memory deficits,one of the earliest hallmarks of Alzheimer’s disease(AD),are closely linked to abnormal neural activity in the dorsolateral prefrontal cortex(DLPFC).Transcranial direct current stimulation(tDCS),a non-invasive neuromodulation therapy,has been shown to ameliorate early AD working memory deficits by modulating excitatory activity in the DLPFC,yet the underlying mechanisms remain incompletely understood.Methods:This investigation was structured around three experimental phases.We initially applied tDCS to stimulate the left prefrontal cortex(PFC)of transgenic mice with 5 familial AD(5×FAD)5 d per week for 4 weeks.Subsequently,we employed optogenetic(Opt)techniques to modulate left PFC glutamatergic neurons.Finally,we inhibited soluble N-ethylmaleimide-sensitive factor attachment receptor(SNARE)expression in the left PFC to elucidate the essential function of SNARE complex assembly with chaperone molecules in orchestrating synaptic vesicle release.Results:tDCS treatment improved working memory deficits in early-stage AD mice.This was accompanied by increased cerebral blood flow,enhanced neuronal excitability,amelioration of neurochemical metabolic disorders,and reduced amyloidβ-protein(Aβ)deposition in the left PFC.Opt stimulation of PFC glutamatergic neurons similarly improved working memory,indicating the association between tDCS’s therapeutic effects and synaptic plasticity of excitatory neurons.Crucially,tDCS facilitated synaptic vesicle fusion and release,evidenced by increased vesicle numbers,enhanced release probability,improved synaptic transmission efficacy,and upregulation of the SNARE complex,Snap25,and Syt1.Inhibiting SNARE expression in the left PFC attenuated the tDCS-induced improvements in synaptic vesicle release and working memory.Conclusion:These findings collectively demonstrate that left PFC-targeted tDCS modulates interactions between the SNARE complex and chaperone molecules,thereby promoting synaptic vesicle fusion and release.This mechanism underlies the amelioration of early AD-like working memory impairment by tDCS. 展开更多
关键词 Transcranial direct current stimulation(tDCS) Dorsolateral prefrontal cortex(DLPFC) Glutamatergic neurons Synaptic vesicle transport Working memory
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Atmospheric Boundary Layer Eco-Environment Shanghuang Observatory:An Integrated Multiscale Research Platform in Southeastern China for Understanding Boundary Layer Processes,Atmospheric Chemistry Feedback,and Extreme Weather–Climate Linkages 认领 引用
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作者 Zifa WANG Xiaole PAN +27 位作者 Yele SUN Jinyuan XIN Hang SU Junji CAO Jie LI Ting YANG Hang LIU Weijie YAO Weiqi XU Xueshun CHEN Wei ZHOU Yongjing MA Xueling CHENG JING YE Bo HU Rubin JIANG Zhe WANG Baozhu GE Lin WU Xinwei LI Jinxi LI Zichen WU Lei KONG Mingming ZHU Jia JIA Xingyu LI Xuekun FANG Lanzhong LIU 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2026年第6期1291-1299,共9页
In the context of global warming,the increasing frequency of extreme weather events,meteorological disasters,and regional pollution events highlights the urgent need for targeted atmospheric observations in ecological... In the context of global warming,the increasing frequency of extreme weather events,meteorological disasters,and regional pollution events highlights the urgent need for targeted atmospheric observations in ecologically sensitive regions.The atmospheric boundary layer top remains a critical yet under-observed interface in climate and environmental research.To respond to this need,the Atmospheric Boundary Layer Eco-Environment Shanghuang Observatory(ABLES)was established in 2023 by the Institute of Atmospheric Physics,Chinese Academy of Sciences in Jinhua,southeastern China.As a high-altitude,state-of-the-art research platform,ABLES addresses the critical need for comprehensive atmospheric and environmental observations in East Asia.The observatory facilitates interdisciplinary research focusing on three core areas:(1)cross-sphere transport of pollutants between atmospheric layers and its environmental and climatic impacts;(2)physical and chemical interactions between clouds and aerosols under extreme weather conditions;and(3)multiscale feedback mechanisms between climate change and ecosystems.ABLES is also aimed at revealing long-term patterns in greenhouse gases,ozone depleting substances,and cloud properties,and to elaborate the formation mechanisms of severe weather events such as thunderstorms and freezing rain.The findings at ABLES will support advances in weather forecasting,air quality modeling,and adaptive strategies for climate resilience.As part of China's growing environmental monitoring network,ABLES has been collaborating with various research organizations,serving as a cooperative research platform for technological development and evidence-based environmental policymaking. 展开更多
关键词 multiscale research platform atmospheric environment extreme meteorology
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Relocation of the Foreshocks and Aftershocks of the 2021 Ms 6.4 Yangbi Earthquake Sequence,Yunnan,China 认领 引用 被引量：21
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作者 Ting Yang Boren Li +5 位作者 Lihua Fang Youjin Su Yusheng Zhong Jingqiong Yang Min Qin Yaji Xu 《Journal of Earth Science》 SCIE CAS CSCD 2022年第4期892-900,共9页
An Ms 6.4 earthquake occurred in Yangbi,Yunnan,China on May 21,2021,which has obvious foreshock activity and abundant aftershocks.Based on the seismic observation data recorded by the Yunnan Seismic Network three days... An Ms 6.4 earthquake occurred in Yangbi,Yunnan,China on May 21,2021,which has obvious foreshock activity and abundant aftershocks.Based on the seismic observation data recorded by the Yunnan Seismic Network three days before and seven days after the mainshock,a doubledifference location method was used to relocate 2133 earthquakes of the Yangbi sequence.Aftershocks are mostly distributed to the southeast of the mainshock in a unilateral rupture pattern.This sequence exhibits a SE-trending linear alignment with a length of about 25 km,and most of the focal depth is above 12 km.Integrated with the seismic distribution and focal mechanism results,we infer that the strike of the seismogenic fault is about 140°,and dipping to the SW.The fault structure revealed by the seismic sequence is complex,with the NW segment exhibiting a steep dip and relatively simple structure of strike-slip rupture and the SE segment consisting of several branching ruptures.The Yangbi Earthquake is a typical foreshock-mainshock-aftershock sequence,and the mainshock is likely triggered by the largest foreshock.This earthquake occurred in the boundary between high-and lowvelocity anomalous zone,where is susceptible to generate large earthquakes. 展开更多
关键词 Yangbi Earthquake Weixi-Qiaohou-Weishan fault earthquake sequence double-difference relocation earthquakes
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CoB and BN composites enabling integrated adsorption/catalysis to polysulfides for inhibiting shuttle-effect in Li-S batteries 认领 引用 被引量：7
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作者 Tianli Wu Ting Yang +4 位作者 Jizong Zhang Xuewen Zheng Kunlin Liu Chengyang Wang Mingming Chen 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2021年第8期220-228,I0005,共9页
Lithium-sulfur(Li-S)batteries are hampered by the infamous shuttle effect and slow redox kinetics,resulting in rapid capacity decay.Herein,a bifunctional catalysis CoB/BN@rGO with integrated structure and synergy effe... Lithium-sulfur(Li-S)batteries are hampered by the infamous shuttle effect and slow redox kinetics,resulting in rapid capacity decay.Herein,a bifunctional catalysis CoB/BN@rGO with integrated structure and synergy effect between adsorption and catalysis is proposed to solve the above problems.The integrated CoB and BN are simultaneously and uniformly introduced on the rGO substrate through a one-step calcination strategy,applied to modify the cathode side of PP separator.The transition metal borides can catalyze the conversion of lithium polysulfides(Li2Sn,n≥4),whereas the bond of B-S is too weak to absorb LPS.Thus BN introduced can effectively restrict the diffusion of polysulfides via strong chemisorption with LiSnLi+…N,while the rGO substrate ensures smooth electron transfer for redox reaction.Therefore,through the integrated adsorption/catalysis,the shuttle effect is suppressed,the kinetics of redox reaction is enhanced,and the capacity decay is reduced.Using CoB/BN@rGO modified PP separator,the Li-S batteries with high initial capacity(1450 mAh g-1at 0.35 mA cm-2)and long-cycle stability(700 cycles at 1.74 mA cm-2with a decay rate of 0.032%per cycle)are achieved.This work provides a novel insight for the preparation of bifunctional catalysis with integrated structure for long-life Li-S batteries. 展开更多
关键词 Integrated structure Synergy effect Bifunctional catalysis Separator Li-S batteries
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Ecological wetland paradigm drives water source improvement in the stream network of Yangtze River Delta 认领 引用 被引量：4
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作者 Weidong Wang Ting Yang +8 位作者 Weibing Guan Weixi Peng Ping Wu Bin Zhong Chundong Zhou Qinghua Chen Rongbin Zhang Kewen Xu Chengqing Yin 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2021年第12期55-72,共18页
Jiaxing created a precedent using bypass riparian marshes to purify micro-polluted water sources in China.Pond-wetland complex with constructed root channel technology becomes a paradigm which can be analogized as&quo... Jiaxing created a precedent using bypass riparian marshes to purify micro-polluted water sources in China.Pond-wetland complex with constructed root channel technology becomes a paradigm which can be analogized as"human-body wetland model"based on bionics or biomimetics.Heterogeneous plant-bed/ditch system with highly active land/water ecotone interfaces,especially meandering boundaries,breeds many biochemical reactions"living areas".Optimization of hydraulic regulation promotes redox environment alternations and wetland treatment efficiency.Here we reported a series of upgrades and performances in Guanjinggang wetland after the Shijiuyang prototype.Morphological reform of plant-bed/ditch system played a vital role.Spatially root channel zone was main force of wetland purification,and temporally the treatment effect was higher in low-temperature seasons indicating non-temperature dependent mechanisms worked.Water pollution comprehensive index improved steadily from IV to III,and comprehensive pollution load was reduced by ca.40%–60%.Comprehensive evaluation function value further showed the gradients purification effect of the upgraded wetland.Ecological wetlands ameliorated source water quality,and reduced drinking water treatment reagents,thereby bringing about economic benefits.Through wetlands operation,people can see how the micro-polluted surface water becomes clear and clean,so promoting a significant social benefit.As a viable component of urban green space,wetlands could beautify regional eco-environment,freshen the air,increase urban ecological taste,and enhance the eco-environmental protection publicity.Thus,the multifunctional service values and indirect benefits are substantial.Jiaxing ecological wetlands provide a typical paradigm for water pollution remediation in developing countries and plays a leading role in technology engineering radiation effect. 展开更多
关键词 Pond-wetland combination Constructed root channel technology Plant-bed/ditch system Semi-subsurface flow wetland Human-body wetland model
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Dissecting the genome of star fruit(Averrhoa carambola L.) 认领 引用 被引量：4
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作者 Yannan Fan Sunil Kumar Sahu +11 位作者 Ting Yang Weixue Mu Jinpu Wei Le Cheng Jinlong Yang Ranchang Mu Jie Liu Jianming Zhao Yuxian Zhao Xun Xu Xin Liu Huan Liu 《Horticulture Research》 SCIE 2020年第1期1626-1635,共10页
Averrhoa carambola is commonly known as star fruit because of its peculiar shape,and its fruit is a rich source of minerals and vitamins.It is also used in traditional medicines in countries such as India,China,the Ph... Averrhoa carambola is commonly known as star fruit because of its peculiar shape,and its fruit is a rich source of minerals and vitamins.It is also used in traditional medicines in countries such as India,China,the Philippines,and Brazil for treating various ailments,including fever,diarrhea,vomiting,and skin disease.Here,we present the first draft genome of the Oxalidaceae family,with an assembled genome size of 470.51 Mb.In total,24,726 protein-coding genes were identified,and 16,490 genes were annotated using various well-known databases.The phylogenomic analysis confirmed the evolutionary position of the Oxalidaceae family.Based on the gene functional annotations,we also identified enzymes that may be involved in important nutritional pathways in the star fruit genome.Overall,the data from this first sequenced genome in the Oxalidaceae family provide an essential resource for nutritional,medicinal,and cultivational studies of the economically important star-fruit plant. 展开更多
关键词 vitamin Brazil cultivation
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Clinical Analysis of Primary Tracheobronchial Tumors in Children and Evaluation of the Predicting Models for Mucoepidermoid Carcinoma 认领 引用 被引量：2
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作者 Chen ZHANG Wen-long FU +11 位作者 Ji-hong DAI Yong-gang LI Xing-ye TANG Xiao-feng MA Gang GENG Ying LI Ting YANG Li YAN Jing-yue LIU Zheng LIU Xiao-ping YUAN Dai-yin TIAN 《Current Medical Science》 SCIE CAS 2022年第4期778-784,共7页
Objective:To determine the clinical characteristics and prognosis of primary tracheobronchial tumors(PTTs)in children,and to explore the most common tumor identification methods.Methods:The medical records of children... Objective:To determine the clinical characteristics and prognosis of primary tracheobronchial tumors(PTTs)in children,and to explore the most common tumor identification methods.Methods:The medical records of children with PTTs who were hospitalized at the Children's Hospital of Chongqing Medical University from January 1995 to January 2020 were reviewed retrospectively.The clinical features,imaging,treatments,and outcomes of these patients were statistically analyzed.Machine learning techniques such as Gaussian na?ve Bayes,support vector machine(SVM)and decision tree models were used to identify mucoepidermoid carcinoma(ME).Results:A total of 16 children were hospitalized with PTTs during the study period.This included 5(31.3%)children with ME,3(18.8%)children with inflammatory myofibroblastic tumors(IMT),2 children(12.5%)with sarcomas,2(12.5%)children with papillomatosis and 1 child(6.3%)each with carcinoid carcinoma,adenoid cystic carcinoma(ACC),hemangioma,and schwannoma,respectively.ME was the most common tumor type and amongst the 3 ME recognition methods,the SVM model showed the best performance.The main clinical symptoms of PPTs were cough(81.3%),breathlessness(50%),wheezing(43.8%),progressive dyspnea(37.5%),hemoptysis(37.5%),and fever(25%).Of the 16 patients,7 were treated with surgery,8 underwent bronchoscopic tumor resection,and 1 child died.Of the 11 other children,3 experienced recurrence,and the last 8 remained disease-free.No deaths were observed during the follow-up period.Conclusion:PTT are very rare in children and the highest percentage of cases is due to ME.The SVM model was highly accurate in identifying ME.Chest CT and bronchoscopy can effectively diagnose PTTs.Surgery and bronchoscopic intervention can both achieve good clinical results and the prognosis of the 11 children that were followed up was good. 展开更多
关键词 tracheobronchial tumors children bronchoscopy clinical characteristics support vector machine model
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Novel insights into the legacy effects of NBPT on fungal interactions and pathogenic fungal reduction in agricultural soils 认领 引用
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作者 Tikun Guan Jilin Lei +7 位作者 Huangwei Liu Jiarui Li Ting Yang Qi Wang Han Wu Meng Wang Weizheng Shu Rui Liu 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第7期328-338,共11页
The use of urease inhibitors,such as N-(n-butyl)thiophosphoric triamide(NBPT),has been seen as an effective strategy to mitigate nitrogen loss from agricultural soils.However,while previous studies have assessed micro... The use of urease inhibitors,such as N-(n-butyl)thiophosphoric triamide(NBPT),has been seen as an effective strategy to mitigate nitrogen loss from agricultural soils.However,while previous studies have assessed microbial impacts under field conditions with repeated NBPT applications,the legacy effects of NBPT degradation on microbial interactions and functions remain underexplored.This study investigated post-degradation impacts of NBPT on soil nitrogen transformation,ammonia(NH3)volatilization,and the diversity,interaction,and function of microbial communities.Soil samples from five diverse Chinese locations were incubated with different NBPT concentrations(0.04%,0.09%,0.15%,0.20%)for 42 days to evaluate sustained effects after NBPT dissipation.Results showed that NBPT significantly slowed urea hydrolysis and reduced excessive ammonium nitrogen(NH4+-N)accumulation.Specifically,cumulative NH3 emissions decreased by 4.54%-49.36% across the tested soils.Moreover,NBPT strengthened interactions among soil fungi without significantly altering the α-diversity of bacterial and fungal communities.Notably,the relative abundance of Aureobasidium(a fungal genus including potential plant pathogens)in NBPT-amended soils(all concentrations pooled)decreased by 98.28%compared to urea-only controls.These findings highlight NBPT's role in fostering resilient microbial communities and suppressing pathogens,underscoring its legacy benefits for soil health despite transient microbial dynamics during incubation.Thus,NBPT application not only effectively reduces NH3 volatilization and regulates nitrogen transformation but also positively impacts soil microbial interactions and functions,promoting improved soil health and ecosystem resilience. 展开更多
关键词 Urease inhibitors Nitrogen transformation NH3volatilization Co-occurrence network Microbial community function
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Difluorocarbene grafted on carbon for high-power supercapacitors 认领 引用
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作者 Kai Gu Zhenyu Chen +6 位作者 Yuxun Yuan Ting Yang Yihan Wang Lei Zhou Lingchao Wu Guilin Feng Weiqing Yang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第7期591-601,I0014,共11页
Biomass-derived activated carbon is a highly promising electrode material for supercapacitors.However,its widespread application is often limited by insufficient power density,stemming from low electrical conductivity... Biomass-derived activated carbon is a highly promising electrode material for supercapacitors.However,its widespread application is often limited by insufficient power density,stemming from low electrical conductivity and sluggish ionic transport.To address these challenges,we developed a difluorocarbene-grafted strategy that fluorinates surface carbonyl groups on carbon through a gassolid reaction path.This process effectively induces a redistribution of carbon atomic electron density and concurrently reconfigures the microporous-mesoporous architecture.The resultant synergistic effects significantly enhance both charge transport efficiency and ionic storage capacity.The optimized fluorinated macadamia nut shell-derived activated carbon(F-MNSAC)exhibits a remarkable compaction density of 0.64 g cm-3,an electrical conductivity of 3.34 S mm-1,and a substantial pore volume of1.213 m3g-1.The supercapacitor based on F-MNSAC delivers a higher specific capacitance(33.63 F g-1at 1 A g-1)than commercialized YP-50F(~27 F g-1at 1 A g-1),and outstanding rate capability(86.6%capacity retention at 50 A g-1).Consequently,the device achieves a high energy density of24.1 Wh kg-1at a high power density of 61.2 kW kg-1.This work establishes a new paradigm for developing high-performance carbon materials and lays a firm technological foundation for advancing nextgeneration,high-power supercapacitors. 展开更多
关键词 Biomass-derived carbon Difluorocarbene grafting Gas-solid reaction High-power supercapacitors Electron density redistribution
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Study on the Thermo-Mechanical Properties of Boron Phenolic Resin Composites Enhanced by Silicone Resin Modification and Multiple Ceramic Fillers 认领 引用
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作者 Mingyan He Jiayu Fu +5 位作者 Fangyu Guo Dawei Jiang Ting Yang Miaojun Xu Zijian Wu Bin Li 《Journal of Polymer Materials》 SCIE CAS 2026年第1期200-214,共15页
Phenolic resins are widely used in thermal protection,yet achieving simultaneous improvement in thermal stability and mechanical strength remains challenging.In this work,a vinyl-modified silicone resin(VMTQ)was synth... Phenolic resins are widely used in thermal protection,yet achieving simultaneous improvement in thermal stability and mechanical strength remains challenging.In this work,a vinyl-modified silicone resin(VMTQ)was synthesized and incorporated into a boron phenolic resin(BPF)matrix.Three composite ceramic fillers,Al2O3-SiO2-ZrO2(ASZ),Al2O3-SiO2-TiO2(AST),and Al2O3-SiO2-MgO(ASM),were further introduced to construct a multi-oxide synergistic reinforcement system.Thermogravimetric analysis shows that the maximum decomposition rate decreases by 0.2-0.3%⋅min-1,while the ASM/V3/BPF-3 composite exhibits a 74.53%increase in char yield at 800℃and a 163.3℃increase in initial decomposition temperature,confirming its significantly enhanced thermal stability.SEM/EDS and XRDanalyses reveal thatASZ,AST,and ASM promote the formation of stable ceramic phases,withASM generating the densest MgO-Al2O3-SiO2composite oxide layer.Mechanical testing demonstrates that ASZ improves vertical impact strength by 23.9%,AST increases parallel impact strength by 14.1%,andASMenhances bending strength by 34.5%(316.8 MPa).These results clearly indicate that the combination of VMTQ modification with multi-oxide ceramic fillers can effectively elevate both the thermal stability and mechanical performance of BPF-based composites,providing a practical pathway for designing high-performance resins for demanding thermal-environment applications. 展开更多
关键词 Ceramic packing silicone resin high temperature resistance
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In silico design of anti-tumor mini-protein targeting MDM2 认领 引用
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作者 Jinghui Zhang Huixin Xu +12 位作者 Baishi Wang Xuekai Zhang Lei Fu Yannan Li Guanzhao Wu Zitong Zhao Lu Liu Ting Yang Zheyu Zhang Jinbo Yang Tao Jiang Peiju Qiu Rilei Yu 《Chinese Chemical Letters》 SCIE CAS CSCD 2023年第5期256-258,共3页
We designed a disulfide-crosslinked mini-protein with a two-helical topology consisting of L-and Damino acids,which was exceptionally stable in serum.Therefore,we further used it as a scaffold to design mini-proteins ... We designed a disulfide-crosslinked mini-protein with a two-helical topology consisting of L-and Damino acids,which was exceptionally stable in serum.Therefore,we further used it as a scaffold to design mini-proteins targeting p53 positive tumor cells.Based on bifunctional grafting,key residues from the transactivation domain of p53 and a designed unnatural amino acid were grafted into the helix constituted by L-amino acids to confer the mini-protein with MDM2 inhibitory activity.Meanwhile,ten Arg residues were introduced to improve its membrane penetrating capacity.Among the mini-proteins,UPROL-10e showed nano-molar binding affinity on MDM2 and cellular toxicity on p53 expressing HCT116cells. 展开更多
关键词 Protein design Antitumor agents In silico design Constrained peptide Epitope grafting
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Response of abundant and rare microbial taxa to three iron-carbon composite amendments in metal-contaminated agricultural soil 认领 引用 被引量：1
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作者 Ting Yang Jiacan Li +6 位作者 Ying Yuan Xin Zheng Yifei Liu Bing Zhang Tan Chen Jun Jin Linlan Zhuang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2025年第11期170-185,共16页
Traditional studies of microbial succession under iron-carbon composite(Fe-C)amendment application have focused on the entire microbial community,with limited attention to the responses and ecological roles of abundan... Traditional studies of microbial succession under iron-carbon composite(Fe-C)amendment application have focused on the entire microbial community,with limited attention to the responses and ecological roles of abundant or rare taxa.Herein,a 90-day microcosm incubation was conducted to investigate the effects of three Fe-C amendments,including Fe3O4-modified biochar(FeC-B),ferrihydrite-natural humic acid(FeC-N),and ferrihydrite-synthetic humic-like acid(FeC-S),on distribution patterns,assembly processes,and ecological functions of both abundant and rare subcommunities.Our results showed that Fe-C amendments significantly affected theα-diversity of rare taxa,particularly under FeC-B treatment,with minimal impact on abundant taxa.Fe-C amendments also reshaped the community structures of both groups.Rare taxa,representing 63.9%of Operational Taxonomic Unit(OTU)richness but only 1.6%of total abundance,played a key role in community diversity and were more susceptible to Fe-C amendments.Certain rare taxa transitioned to abundant status,demonstrating their potential as a microbial seed bank.Abundant taxa were positioned more centrally within the networks,and Fe-C applications promoted cooperative interactions between abundant and rare species.Deterministic processes dominated the assembly of the rare subcommunity,while stochastic processes primarily influenced the abundant bacterial community.Fe-C amendments reduced community differentiation among rare taxa while increasing variability among abundant groups.Functional diversity of rare groups surpassed that of abundant groups,with notable enhancement in nitrogen cycling-related genes under Fe-C treatments.This study highlights the complementary roles of abundant and rare taxa in soil remediation,providing insights for optimizing remediation strategies. 展开更多
关键词 Metal-contaminated farmland Iron-carbon composite amendments Abundant taxa Rare taxa Community assembly Ecological functions
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Metabolomic profiling reveals distinct metabolic patterns and a potential circulating biomarker in pre-COPD 认领 引用 被引量：1
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作者 Xiaoxia Ren Junling Pang +7 位作者 Ruoxi He Junchao Jiang Zaiyong Wang Yanyan Xu Sheng Xie Ting Yang Jing Wang Chen Wang 《Chinese Medical Journal》 SCIE CAS CSCD 2026年第10期1578-1580,共3页
To the Editor:Chronic obstructive pulmonary disease(COPD)is a common,preventable,and treatable lung condition characterized by the progressive obstruction of the airway following chronic inflammation of airways and/or... To the Editor:Chronic obstructive pulmonary disease(COPD)is a common,preventable,and treatable lung condition characterized by the progressive obstruction of the airway following chronic inflammation of airways and/or alveoli.The prevalence of spirometry-defined COPD,which is characterized by post-bronchodilator forced expiratory volume in one second/forced vital capacity(FEV1/FVC)ratio<0.7 in adults aged≥40 years,is estimated to be 13.7%in the China Pulmonary Health(CPH)study.[1]Unfortunately,due to the asymptomatic initiation,COPD is underdiagnosed,resulting in missed opportunities to treat the condition.Patients with undiagnosed early-stage COPD are likely to progress to more advanced stages,which are associated with poor health-related quality of life and increased healthcare costs. 展开更多
关键词 pre copd fev fvc ratio obstructive pulmonary disease copd metabolomic profiling chronic obstructive pulmonary disease circulating biomarker spirometry defined copd progressive obstruction airway
Two-dimensional design strategy to construct smart dual-responsive fluorescent probe for the precise tracking of ischemic stroke 认领 引用
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作者 Jiayu Zeng Minhui Liu +6 位作者 Ting Yang Jia Huang Songjiao Li Wanting Zhang Dan Cheng Longwei He Jia Zhou 《Chinese Chemical Letters》 SCIE CAS CSCD 2025年第5期536-542,共7页
Early recognition is key to improving the prognosis of ischemic stroke(IS),while available imaging methods tend to target events that have already undergone ischemia.A new method to detect early IS is urgently needed,... Early recognition is key to improving the prognosis of ischemic stroke(IS),while available imaging methods tend to target events that have already undergone ischemia.A new method to detect early IS is urgently needed,as well as further study of its mechanisms.Viscosity and cysteine(Cys)levels of mitochondria have been associated with ferroptosis and IS.It is possible to identify IS and ferroptosis accurately and early by monitoring changes in mitochondrial Cys and viscosity simultaneously.In this work,a viscosity/Cys dual-responsive mitochondrial-targeted near-infrared(NIR)fluorescent probe(NVCP)was constructed for the precise tracking of IS using a two-dimensional design strategy.NVCP consists of a chromophore dyad containing diethylaminostyrene quinolinium rotor and chloro-sulfonylbenzoxadiazole(SBD-Cl)derivative with two easily distinguished emission bands(λem=592 and 670 nm).NVCP performs the way of killing two birds with one stone,that is,the probe exhibits excellent selectivity and sensitivity for detecting viscosity and Cys in living cells with excellent biocompatibility and accurate mitochondrial targeting capability by dual channel imaging mode.In addition,NVCP recognized that the viscosity increases and Cys level decreases in cells when undergoing ferroptosis and oxygen-glucose deprivation(OGD)stress by confocal imaging,flow cytometry,and Western blot experiments.Treatment of ferroptosis inhibitors(ferrostatin-1(Fer-1)and deferoxamine(DFO))could reverse the variation tendency of viscosity and Cys.This is the first time that the relationship between ferroptosis and IS was identified through an analysis of Cys and viscosity.More importantly,the ischemic area was also instantly distinguished from normal tissues through fluorescence imaging of NVCP in vivo.The developed NIR dual-responsive probe NVCP toward viscosity and Cys could serve as a sensitive and reliable tool for tracking ferroptosis-related pathological processes during IS. 展开更多
关键词 Ischemic stroke Ferroptosis Viscosity Cysteine Mitochondria Fluorescent probe
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Multiscale analysis of microstructure-based bending characteristics of advanced high strength dual-phase steel 认领 引用
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作者 Ming-shuai Huo Hai-bo Xie +10 位作者 Tao Zhang Guan-qiao Su Lian-jie Li Meng-yuan Ren Zhou Li Jing-bao Liu Ting Yang Xi Zhang Yan-bin Du Valerie Linton Zheng-yi Jiang 《Journal of Iron and Steel Research International》 SCIE EI CAS CSCD 2025年第7期2054-2063,共10页
Different stress states have a significant influence on the magnitude of the microscopic plastic strain and result in the development of the microstructure evolution.As a result,a comprehensive understanding of the di... Different stress states have a significant influence on the magnitude of the microscopic plastic strain and result in the development of the microstructure evolution.As a result,a comprehensive understanding of the different scale variation on microstructure evolution during bending deformation is essential.The advanced high strength dual-phase(DP1180)steel was investigated using multiscale microstructure-based 3D representative volume element(RVE)modelling technology with emphasis on understanding the relationship between the microstructure,localised stress-strain evolution as well as the deformation characteristics in the bending process.It is demonstrated that the localised development in bending can be more accurately described by microscopic deformation when taking into account microstructural properties.Microstructure-based 3D RVEs from each chosen bending condition generally have comparable localisation properties,whilst the magnitudes and intensities differ.In addition,the most severe localised bands are predicted to occur close to the ferrite and martensite phase boundaries where the martensite grains are close together or have a somewhat sharp edge.The numerically predicted results for the microstructure evolution,shear bands development and stress and strain distribution after 3-point bending exhibit a good agreement with the relevant experimental observations. 展开更多
关键词 Advanced high strength dual-phase steel 3D representative volume element Microstructure-based modelling Bending characteristics Multiscaleanalysis
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Albumin nanoassembly bi-directionally manipulated ferroptosis in tumor and CD8+T cells for triple-negative breast cancer therapy 认领 引用 被引量：2
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作者 Ting Yang Zihan Liu +9 位作者 Zixuan Fu Xiaojie Zhang Yongjin Cao Qiangwei Liang Jiale Miao Hao Yang Tong Zhang Jing Hei Weiqing Ni Yanhua Liu 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS CSCD 2025年第2期146-159,共14页
Ferroptosis can serve as a potent strategy for regulating cell death via lipid peroxidation and the imbalance of the antioxidant system resulting from iron accumulation in triple-negative breast cancer(TNBC)therapy.Ho... Ferroptosis can serve as a potent strategy for regulating cell death via lipid peroxidation and the imbalance of the antioxidant system resulting from iron accumulation in triple-negative breast cancer(TNBC)therapy.However,the ferroptosis accompanied with down-regulation of glutathione peroxidase 4(GPX4)lead to CD36-mediated tumor-infiltrating CD8+T cells uptaking fatty acids,resulting in the negative action on immunotherapeutic efficacy.Herein,the albumin nanoparticles,abbreviated as LHS NPs,were designed by co-assembly of hemin,linoleic acid-cystamine,and a CD36 inhibitor sulfosuccinimide oleate,to bi-directionally manipulated ferroptosis in tumor and CD8+T cells for TNBC therapy.LHS NPs exerted more efficient reactive oxygen species generation,glutathione depletion and malondialdehyde production by the combinatory strategy of classical and non-classical ferroptosis modes,which amplified the positive action on ferroptosis in tumor cells.Meanwhile,LHS manipulated the negative action of ferroptosis by inhibiting the CD36 mediated-lipid peroxidation in CD8+T cells,thereby activating the immunotherapeutic efficacy with the improvements on induction of immunogenic cell death,proliferation of CD4+CD8+T cells and natural killer cells,alleviation immunosuppressive regulatory T cells and myeloid-derived suppressor cells,and repolarization of the M2-to M1-phenotype tumor-associated macrophages.Thus,LHS NPs demonstrated an improved antitumor efficacy in suppressing the tumor growth and lungmetastasis of 4T1-tumormice.Our work gives novel insights for the bi-directionally manipulating ferroptosis in tumor and CD8+T cells on TNBC chemoimmunotherapy. 展开更多
关键词 Albumin nanoassembly Bi-directionally manipulated ferroptosis Lipid peroxidation CD36-mediated CD8+T cell ferroptosis Triple-negative breast cancer
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Combined mesenchymal and neural stem cell therapy enhances neurological recovery in cerebral infarction 认领 引用 被引量：3
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作者 Ting Yang Hui Yu +1 位作者 Dong Han Zheng Xie 《World Journal of Stem Cells》 SCIE 2025年第9期108-116,共9页
BACKGROUND Acute cerebral infarction(ACI),a leading cause of death and disability,causes brain ischemia due to vessel blockage.Current time-limited interventions,such as clot removal,often fail to restore full functio... BACKGROUND Acute cerebral infarction(ACI),a leading cause of death and disability,causes brain ischemia due to vessel blockage.Current time-limited interventions,such as clot removal,often fail to restore full function.Neurorestoration is vital,but complicated.Vascular endothelial growth factor(VEGF)and basic fibroblast growth factor(bFGF)promote angiogenesis and neuroprotection.Stem cell therapy has potential to promote neurorestoration.Specifically,neural stem cells(NSC)reconstruct neural tissue,while mesenchymal stem cells(MSCs)provide support and secrete beneficial factors.Combining NSCs and MSCs in stem cell therapy may synergistically enhance ACI recovery,potentially via the regulation of VEGF and bFGF.However,the mechanisms underlying this combined approach remain unclear.AIM To investigate the therapeutic effect of combined NSC and MSC transplantation on neurological recovery and bFGF/VEGF expression in ACI patients.METHODS This study enrolled 156 patients with ACI treated from June 2022 to June 2023.Patients were randomly assigned to two groups:The control group(n=78)received conventional drug therapy,while the observation group(n=78)received conventional therapy and combined NSC and MSC transplantation.The following outcomes were compared between groups:National Institutes of Health Stroke Scale(NIHSS)score,Barthel index,cerebral perfusion and diffusion on magnetic resonance imaging,serum bFGF and VEGF levels,clinical efficacy,and adverse events.RESULTS Serum VEGF and bFGF levels negatively correlated with NIHSS scores in patients with ACI(r=-0.388,r=-0.239;P<0.05).The observation group(NSC and MSC)showed a significantly higher clinical efficacy of treatment than the controls(85.9%vs 69.2%;P<0.05).Both groups showed improved cerebral perfusion,increased Barthel index,and decreased NIHSS scores post-treatment(P<0.05),with significantly greater improvements in the observation group.Serum VEGF and bFGF levels increased significantly in both groups(P<0.05),but were higher in the observation group.Adverse events in the observation group(transient fever:4 cases;agitation:1 case;headache:2 cases)were mild and resolved with symptomatic treatment.Six-month follow-up revealed no abnormalities in magnetic resonance imaging,electrocardiogram,or blood tests.CONCLUSION NSC-MSC combination therapy enhances neurological function and cerebral perfusion in patients with ACI by upregulating VEGF and bFGF expression,demonstrating favorable clinical efficacy and safety. 展开更多
关键词 Acute cerebral infarction Neural stem cells Mesenchymal stem cells Vascular endothelial growth factor Basic fibroblast growth factor Neurological function
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