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Molecular Investigations on the Diffusion of Hydrated Ions and Its Effects on the Plastic Deformation of Ultra-high Molecular Weight Polyethylene at Seawater Condition 认领 引用
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作者 Qi-Hao Cheng Ting Zheng +1 位作者 Gang Yang Hui-Chen Zhang 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2026年第1期299-313,I0019,共15页
Ultra-high molecular weight polyethylene(UHMWPE)is a key material for marine applications owing to its outstanding self-lubrication and corrosion resistance.However,its long-term performance is compromised by plastic ... Ultra-high molecular weight polyethylene(UHMWPE)is a key material for marine applications owing to its outstanding self-lubrication and corrosion resistance.However,its long-term performance is compromised by plastic deformation in seawater.In this study,we performed a comparative analysis of the UHMWPE dynamics under seawater and water conditions to investigate the plastic deformation of UHMWPE induced by seawater.The results show that the plastic deformation of UHMWPE is amplified in seawater relative to the water conditions.Under thin fluid conditions,frictional interfaces exhibit a higher interfacial friction force and interaction energy in seawater than in water.Compared to freely diffused water molecules,hydrated ions occupy larger interchain spaces within polyethylene.Furthermore,the diffusion of hydrated ions weakens the interchain interactions,promoting more severe polyethylene chain rearrangement and accelerating seawater-induced plastic deformation in UHMWPE during friction.Furthermore,the diffused seawater accelerated the disentangling of the polyethylene chains and enhanced the orderly orientation distribution of polyethylene.Compared to free water molecules,the water molecules of hydrated ions exhibit enhanced attraction to free-flowing water molecules,thereby accelerating seawater flow across submerged UHMWPE surfaces.This flow enhancement promotes surface polyethylene chain mobility in seawater. 展开更多
关键词 Ultra-high molecular weight polyethylene Plastic deformation Seawater Hydrated ion Molecular dynamics
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Causes of epigastric pain and vomiting after laparoscopic-assisted radical right hemicolectomy-superior mesenteric artery syndrome 认领 引用
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作者 Juan Xie Jiao Bai +2 位作者 Ting Zheng Jian Shu Ma-Li Liu 《World Journal of Gastrointestinal Surgery》 SCIE 2023年第2期193-200,共8页
BACKGROUND Superior mesenteric artery syndrome(SMAS)is a rare condition causing functional obstruction of the third portion of the duodenum.Postoperative SMAS following laparoscopic-assisted radical right hemicolectom... BACKGROUND Superior mesenteric artery syndrome(SMAS)is a rare condition causing functional obstruction of the third portion of the duodenum.Postoperative SMAS following laparoscopic-assisted radical right hemicolectomy is even less prevalent and can often be unrecognized by radiologists and clinicians.AIM To analyze the clinical features,risk factors,and prevention of SMAS after laparoscopic-assisted radical right hemicolectomy.METHODS We retrospectively analyzed clinical data of 256 patients undergoing laparoscopicassisted radical right hemicolectomy in the Affiliated Hospital of Southwest Medical University from January 2019 to May 2022.The occurrence of SMAS and its countermeasures were evaluated.Among the 256 patients,SMAS was confirmed in six patients(2.3%)by postoperative clinical presentation and imaging features.All six patients were examined by enhanced computed tomography(CT)before and after surgery.Patients who developed SMAS after surgery were used as the experimental group.A simple random sampling method was used to select 20 patients who underwent surgery at the same time but did not develop SMAS and received preoperative abdominal enhanced CT as the control group.The angle and distance between the superior mesenteric artery and abdominal aorta were measured before and after surgery in the experimental group and before surgery in the control group.The preoperative body mass index(BMI)of the experimental group and the control group was calculated.The type of lymphadenectomy and surgical approach in the experimental and control groups were recorded.The differences in angle and distance were compared preoperatively and postoperatively in the experimental group compared.The differences in angle,distance,BMI,type of lymphadenectomy and surgical approach between the experimental and control groups were compared,and the diagnostic efficacy of the significant parameters was assessed using receiver operating characteristic curves.RESULTS In the experimental group,the aortomesenteric angle and distance after surgery were significantly decreased than those before surgery(P0.05).CONCLUSION The small preoperative aortomesenteric angle and distance and low BMI may be important factors for the complication.Over-cleaning of lymph fatty tissues may also be associated with this complication. 展开更多
关键词 Right hemicolectomy Superior mesenteric artery syndrome X-ray computed tomography
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Histone deacetylases 10 as a prognostic biomarker correlates with tumor microenvironment and therapy response in colorectal cancer 认领 引用 被引量：2
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作者 Hai-Hang Nie Xue-Ying Yang +11 位作者 Jing-Kai Zhou Gui-Lin Gao Lu Ding Yun-Tian Hong Ya-Li Yu Pei-Shan Qiu Zi-Yue Zeng Jun Lai Ting Zheng Hai-Zhou Wang Qiu Zhao Fan Wang 《World Journal of Gastroenterology》 SCIE CAS 2025年第26期137-155,共19页
BACKGROUND The histone deacetylases 10(HDAC10)is a HDAC family member,yet its importance in the context of colorectal cancer(CRC)development remains incompletely understood.The present study was thus developed to expl... BACKGROUND The histone deacetylases 10(HDAC10)is a HDAC family member,yet its importance in the context of colorectal cancer(CRC)development remains incompletely understood.The present study was thus developed to explore the mechanistic importance of HDAC10 as a regulator of CRC.AIM To investigate the impact of HDAC10 on tumor growth and its regulation in tumor microenvironment(TME)in CRC,we conducted this study.METHODS The study evaluated HDAC10 expression using immunohistochemistry analyses and assessed its prognostic value in CRC patients.HDAC10 depletion CRC cell lines were generated,and its biological functions were assessed through cell counting kit-8,wound healing,and colony formation assays.Furthermore,gene set variation analysis(GSVA)was employed to explore the potential molecular mechanisms of HDAC10 in CRC.The impact of HDAC10 on TME was subsequently assessed.Finally,the study investigated the influence of HDAC10 on the response to immunotherapy and chemotherapeutic drugs in CRC.RESULTS HDAC10 expression was significantly elevated in CRC and correlated with poor prognosis in patients.Knockdown of HDAC10 reduced colon cancer cell proliferation and migration capabilities.GSVA revealed a strong association between high HDAC10 expression and immune suppression.Additionally,high HDAC10 levels were correlated with a non-inflamed TME.Finally,patients with high HDAC10 expression showed reduced sensitivity to immuno-therapy.CONCLUSION This study revealed the significance of HDAC10 in TME,therapy efficacy,and clinical prognosis in CRC,offering novel insights for therapeutic advancements in CRC. 展开更多
关键词 Histone deacetylases 10 Colorectal cancer Tumor microenvironment Immunotherapy Prognosis
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Endoplasmic reticulum stress in gut inflammation:Implications for ulcerative colitis and Crohn’s disease 认领 引用
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作者 Ting Zheng Kai-Yue Huang +2 位作者 Xu-Dong Tang Feng-Yun Wang Lin Lv 《World Journal of Gastroenterology》 SCIE CAS 2025年第13期7-21,共15页
Eukaryotic cells contain the endoplasmic reticulum(ER),a prevalent and intricate membranous structural system.During the development of inflammatory bowel disease(IBD),the stress on the ER and the start of the unfolde... Eukaryotic cells contain the endoplasmic reticulum(ER),a prevalent and intricate membranous structural system.During the development of inflammatory bowel disease(IBD),the stress on the ER and the start of the unfolded protein response are very important.Some chemicals,including 4μ8C,small molecule agonists of X-box binding protein 1,and ISRIB,work on the inositol-requiring enzyme 1,turn on transcription factor 6,and activate protein kinase RNA-like ER kinase path-ways.This may help ease the symptoms of IBD.Researchers investigating the gut microbiota have discovered a correlation between ER stress and it.This suggests that changing the gut microbiota could help make new medicines for IBD.This study looks at how ER stress works and how it contributes to the emergence of IBD.It also talks about its possible clinical importance as a therapeutic target and looks into new ways to treat this condition. 展开更多
关键词 Endoplasmic reticulum stress Unfolded protein response Inflammatory bowel disease Mechanism of action Clinical treatment
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Research on Bearing Fault Diagnosis Method Based on Deep Learning 认领 引用 被引量：1
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作者 Ting Zheng 《Journal of Electronic Research and Application》 2025年第1期1-6,共6页
Bearing is an indispensable key component in mechanical equipment,and its working state is directly related to the stability and safety of the whole equipment.In recent years,with the rapid development of artificial i... Bearing is an indispensable key component in mechanical equipment,and its working state is directly related to the stability and safety of the whole equipment.In recent years,with the rapid development of artificial intelligence technology,especially the breakthrough of deep learning technology,it provides a new idea for bearing fault diagnosis.Deep learning can automatically learn features from a large amount of data,has a strong nonlinear modeling ability,and can effectively solve the problems existing in traditional methods.Aiming at the key problems in bearing fault diagnosis,this paper studies the fault diagnosis method based on deep learning,which not only provides a new solution for bearing fault diagnosis but also provides a reference for the application of deep learning in other mechanical fault diagnosis fields. 展开更多
关键词 Deep learning Bearing failure Diagnostic methods
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Adding programmed death 1/programmed death ligand 1 inhibitors to first-line standard-of-care therapy for metastatic colorectal cancer:A meta-analysis 认领 引用
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作者 Ting Zheng Xing-Xing Li +1 位作者 Li Zhou Jian-Jiang Jin 《World Journal of Clinical Oncology》 2025年第8期230-242,共13页
BACKGROUND In recent years,emerging clinical research has prioritized assessment of combined therapeutic efficacy and safety parameters when programmed death 1 or its ligand(PD-1/L1)inhibitors are incorporated into fi... BACKGROUND In recent years,emerging clinical research has prioritized assessment of combined therapeutic efficacy and safety parameters when programmed death 1 or its ligand(PD-1/L1)inhibitors are incorporated into first-line standard-of-care(SOC)therapy for metastatic colorectal cancer(mCRC).However,data obtained from these trials demonstrated conflicting evidence concerning survival benefits and clinical outcomes.AIM To evaluate the therapeutic impact and safety parameters of combining PD-1/L1 inhibitors with SOC protocols as first-line treatment for mCRC.METHODS Four biomedical databases(PubMed,Embase,Cochrane Library,Web of Science)were systematically interrogated to identify eligible studies published up to October 12,2024.The analysis focused on evaluating the primary outcome of overall survival(OS)in the mCRC population with secondary outcomes of progression-free survival(PFS),overall response rate(ORR),and incidence rate of grade≥3 adverse events.Additionally,we performed exploratory analyses in the microsatellite stable/mismatch repair-proficient(MSS/pMMR)subpopulation,based on a subset of the included studies.Subgroup analyses according to PD-1/L1 inhibitor use were conducted in both the overall population and the MSS/pMMR subgroup.RESULTS This pooled analysis incorporated six randomized controlled trials involving 675 patients with mCRC receiving first-line therapy.The combination of PD-1/L1 inhibitors with SOC regimens demonstrated a significant PFS advantage over SOC monotherapy in intention-to-treat populations[hazard ratio(HR)=0.8,95%confidence interval(CI):0.65-0.98,P=0.033].Nevertheless,the MSS/pMMR subgroup showed no PFS benefit(HR=0.83,95%CI:0.67-1.03,P=0.091),and no cohort exhibited OS improvement(intention-to-treat:HR=0.84,95%CI:0.66-1.05,P=0.124;MSS/pMMR:HR=0.79,95%CI:0.60-1.03,P=0.083).Comparable outcomes were observed for ORR(risk ratio=1.03,95%CI:0.90-1.17,P=0.711)and incidence rate of grade≥3 adverse events(risk ratio=1.12,95%CI:0.93-1.36,P=0.245)between treatment arms.CONCLUSION The findings indicated that integrating PD-1/L1 blocking agents with SOC regimens for mCRC as first-line treatment failed to demonstrate significant improvements in ORR.Existing clinical data remain inadequate to establish OS advantages,particularly in patients with MSS/pMMR,despite exhibiting manageable toxicity profiles.Subsequent confirmation through rigorously designed phase III clinical trials remains essential to verify these therapeutic outcomes. 展开更多
关键词 Programmed death 1 Programmed death ligand 1 Standard-of-care Metastatic colorectal cancer First-line Metaanalysis
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Cellulose Nanopaper:Fabrication,Functionalization,and Applications 认领 引用 被引量：43
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作者 Wei Liu Kun Liu +7 位作者 Haishun Du Ting Zheng Ning Zhang Ting Xu Bo Pang Xinyu Zhang Chuanling Si Kai Zhang 《Nano-Micro Letters》 SCIE EI CAS CSCD 2022年第6期323-349,共27页
Cellulose nanopaper has shown great potential in diverse fields including optoelectronic devices,food packaging,biomedical application,and so forth,owing to their various advantages such as good flexibility,tunable li... Cellulose nanopaper has shown great potential in diverse fields including optoelectronic devices,food packaging,biomedical application,and so forth,owing to their various advantages such as good flexibility,tunable light transmittance,high thermal stability,low thermal expansion coefficient,and superior mechanical properties.Herein,recent progress on the fabrication and applications of cellulose nanopaper is summarized and discussed based on the analyses of the latest studies.We begin with a brief introduction of the three types of nanocellulose:cellulose nanocrystals,cellulose nanofibrils and bacterial cellulose,recapitulating their differences in preparation and properties.Then,the main preparation methods of cellulose nanopaper including filtration method and casting method as well as the newly developed technology are systematically elaborated and compared.Furthermore,the advanced applications of cellulose nanopaper including energy storage,electronic devices,water treatment,and high-performance packaging materials were highlighted.Finally,the prospects and ongoing challenges of cellulose nanopaper were summarized. 展开更多
关键词 Nanocellulose Cellulose nanopaper Cellulose nanocrystals Cellulose nanofibrils Cellulose nanomaterials
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Straw mulch-based no-tillage improves tillering capability of dryland wheat by reducing asymmetric competition between main stem and tillers 认领 引用 被引量：8
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作者 Hongkun Yang Yun Xiao +7 位作者 Peng He Dailong Ai Qiaosheng Zou Jian Hu Qiong Liu Xiulan Huang Ting Zheng Gaoqiong Fan 《The Crop Journal》 SCIE CSCD 2022年第3期864-878,共15页
The moisture-conserving effect of straw mulch-based no-tillage(SMNT)is expected to increase fertile spikes and grain yield in environments with rainfall less than 200 mm.However,the mechanisms under-lying the positive... The moisture-conserving effect of straw mulch-based no-tillage(SMNT)is expected to increase fertile spikes and grain yield in environments with rainfall less than 200 mm.However,the mechanisms under-lying the positive effect of SMNT on wheat tillering are not fully elucidated.A split-plot experiment was designed to investigate the combined effects of SMNT and cultivars on tillering of dryland wheat grown under both dry and favorable climates.Application of SMNT to a cultivar with 1-2 tillers exploited both tillering and kernel-number plasticity,increasing the mean grain yield by 20.5%.This increase was attrib-uted primarily to an increased first-tiller emergence rate resulting from increased N uptake,leaf N con-tent,and N remobilization from tillers to their grain.The second and third tillers,as transient sinks,contributed to the tiller survival rate,which depends on tiller leaf number.The increased total N uptake by SMNT also increased the dry mass yield of tillers and the C:N ratio,reducing the asymmetric compe-tition between main stem and tillers.Owing to these beneficial effects,reduced mitogen-activated pro-tein kinase(MAPK)and abscisic acid signals were observed under SMNT,whereas indole-3-acetic acid(IAA)signals and genes involved in DNA replication and mismatch repair were increased.These signals activated three critical transcription factors(the calmodulin-binding transcription activator,GRAS domain,and cysteine-2/histidine-2 family)and further increased rapid drought response and tiller main-tenance after stem extension.Phenylpropanoid biosynthesis,sphingolipid biosynthesis,and galactose metabolism were most relevant to increased tillering under SMNT because of their critical role in drought response and lignin biosynthesis.Our results suggest that straw mulch-based no-tillage activates rapid drought response and improved wheat tillering by coordinating root N uptake,N remobilization,and asymmetric competition between main stem and tillers. 展开更多
关键词 Straw mulch-basedno-tillage Wheat tillering Stable isotopetracing Transcriptome Metabolomics
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Synergy of lead vacancies and morphotropic phase boundary to promote high piezoelectricity and temperature stability of PBZTN ceramics 认领 引用 被引量：3
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作者 Wenbin Liu Ting Zheng +6 位作者 Xuezheng Ruan Zhenyong Man Haoyue Xue Laiming Jiang Fuping Zhang Guorong Li Jiagang Wu 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2023年第6期1-7,共7页
The flourishing development of emerging electromechanical applications has stimulated an urgent demand for ferroelectric ceramics with high piezoelectric properties and broad temperature usage range.However,it remains... The flourishing development of emerging electromechanical applications has stimulated an urgent demand for ferroelectric ceramics with high piezoelectric properties and broad temperature usage range.However,it remains a challenge to simultaneously obtain good piezoelectricity and reliable temperature stability in lead zirconate titanate(PZT)-based piezoelectric ceramics.To solve this issue,a synergetic strategy was proposed to introduce lead vacancies through niobium doping and construct morphotropic phase boundary(MPB).In this work,Pb0.905Ba0.085(V Pb″)0.01[(ZrxTi1-x)0.98Nb0.02]O3(PBZTN-x)material system was designed.Good comprehensive properties(d33=864 pC/N,kp=84%,TC=201℃)and excellent temperature stability(less than 10%variation of electrical properties from 20℃ to 160℃)were obtained in PBZTN-0.540 ceramics.Good piezoelectricity can be attributed to high extrinsic contribution(domain wall motion)induced by Pb2+vacancies and the existence of nano-domains emerged at MPB,while excellent temperature stability is mainly attributed to the minimized local stress in the lattice and the stable domain structure. 展开更多
关键词 Piezoelectricity Lead vacancies Morphotropic phase boundary Temperature stability
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Ultra-broad temperature insensitive Pb(Zr,Ti)O3-based ceramics with large piezoelectricity 认领 引用 被引量：2
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作者 Wenbin Liu Fuping Zhang +5 位作者 Ting Zheng Hongjiang Li Yi Ding Xiang Lv Zhipeng Gao Jiagang Wu 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2024年第25期19-27,共9页
The rapid growth of new electromechanical applications has increased the demand for ferroelectric ce-ramics with excellent piezoelectric properties and a wide temperature operating range.However,achiev-ing robust piez... The rapid growth of new electromechanical applications has increased the demand for ferroelectric ce-ramics with excellent piezoelectric properties and a wide temperature operating range.However,achiev-ing robust piezoelectricity and temperature stability simultaneously in lead zirconate titanate(Pb(Zr,Ti)O3)based piezoelectric ceramics poses a significant challenge.This study proposes a new material system of 0.98Pb0.84Ba0.16(Zr2/3Ti1/3)O3-0.02Pb(Sb1/2Nb1/2)O3+x wt.%Sm2O3(PBZT-PSN-x Sm)to address this challenge.Remarkably,the ceramics x=0.4 demonstrate excellent piezoelectric properties(includ-ing piezoelectric coefficient d33 of 610 pC/N and Curie temperature TC of 290℃)and favorable tem-perature stability(i.e.,d33 varies less than 10%within 25-200℃).The high piezoelectric properties arise from the optimized phase fraction between rhombohedral(R)and tetragonal(T)phases and the increased grain size,which enhance the lattice distortion and the domain switching under electric fields,respectively.The superior temperature stability can be attributed to stable crystal structure and domain structure.These findings indicate that PBZT-PSN-x Sm ceramics hold great promise for practical utilization in high-temperature transducers and sensors. 展开更多
关键词 Pb(Zr,Ti)O3ceramics Piezoelectricity Temperature stability Sm2O3doping
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Specificity of CRISPR/Cpf1 on single-nucleotide mismatched target sites 认领 引用
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作者 Mingrui Wang Qi Wan +4 位作者 Yao Wang Sicong Tian Ting Zheng Yingzi Hou Quan Du 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2019年第1期1-9,共9页
CRISPR/Cas has been coming to prosperity since its discovery and application. It becomes a standard solution for gene editing in the past few years. A guide RNA is used to lead the endonuclease, such as Cas9 and Cpf1,... CRISPR/Cas has been coming to prosperity since its discovery and application. It becomes a standard solution for gene editing in the past few years. A guide RNA is used to lead the endonuclease, such as Cas9 and Cpf1, to specific sites and break the double strand. However, there is also possibility that the system will cut a non-specific position, which is called 'off-target effect'. The off-target cleavage may cause trouble to gene function research or clinic treatment. In order to reveal the target specificity of Cpf1, this study explored the single-nucleotide mismatches by a dual-luciferase system. Our results showed that the poly(T) structure was prohibitive in spacer for Cpf1 targeting. Moreover, rA mismatches seemed to be of the least tolerance for CRISPR/Cpf1, which was same as CRISPR/Cas9. The phenomenon might be attributed to the homology of the two enzymes. In summary, our research suggest that more attention should be paid to off-target effects when using CRISPR/Cpf1 or CRISPR/Cas9, as this is an intrinsic characteristic of the system. 展开更多
关键词 CRISPR Cpf1 Cas9 Off-target effect
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Improving the stability and bioavailability of tea polyphenols by encapsulations:a review 认领 引用 被引量：17
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作者 Zhiya Yin Ting Zheng +3 位作者 Chi-Tang Ho Qingrong Huang Qingli Wu Man Zhang 《Food Science and Human Wellness》 SCIE CAS CSCD 2022年第3期537-556,共20页
Tea polyphenols(TPPs)have attracted significant research interest due to their health benefits.However,TPPs are sensitive to certain environmental and gastrointestinal conditions and their oral bioavailability was fou... Tea polyphenols(TPPs)have attracted significant research interest due to their health benefits.However,TPPs are sensitive to certain environmental and gastrointestinal conditions and their oral bioavailability was found to be very low.Delivery systems made of food-grade materials have been reported to improve the shelf-life,bioavailability and bioefficacy of TPPs.This review discusses the chemistry of TPPs;the setbacks of TPPs for application;and the strategies to counteract application limitations by rationally designing delivery systems.An overview of different formulations used to encapsulate TPPs is provided in this study,such as emulsion-based systems(liposome,nanoemulsion,double emulsion,and Pickering emulsion)and nano/microparticles-based systems(protein-based,carbohydrate-based,and bi-polymer based).In addition,the stability,bioavailability and bioactivities of encapsulated TPPs are evaluated by various in vitro and in vivo models.The current findings provide scientific insights in encapsulation approaches for the delivery of TPPs,which can be of great value to TPPs-fortified food products.Further explorations are needed for the encapsulated TPPs in terms of their applications in the real food industry as well as their biological fate and functional pathways in vivo. 展开更多
关键词 Tea polyphenols Encapsulation Stability Bioavailability Bioefficacy
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The dynamic metabolic profile of Qi-Yu-San-Long decoction in rat urine using UPLC-QTOF-MSE coupled with a post-targeted screening strategy 认领 引用 被引量：4
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作者 Ting Zheng Yue Zhao +4 位作者 Ruijuan Li Mengwen Huang An Zhou Zegeng Li Huan Wu 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2022年第5期755-765,共11页
Qi-Yu-San-Long decoction(QYSLD)is a traditional Chinese medicine that has been clinically used in the treatment of non-small-cell lung cancer(NSCLC)for more than 20 years.However,to date,metabolicrelated studies on QY... Qi-Yu-San-Long decoction(QYSLD)is a traditional Chinese medicine that has been clinically used in the treatment of non-small-cell lung cancer(NSCLC)for more than 20 years.However,to date,metabolicrelated studies on QYSLD have not been performed.In this study,a post-targeted screening strategy based on ultra-performance liquid chromatography coupled with quadrupole time-of-flight full information tandem mass spectrometry(UPLC-QTOF-MSE)was developed to identify QYSLD-related xenobiotics in rat urine.The chemical compound database of QYSLD constituents was established from previous research,and metabolites related to these compounds were predicted in combination with their possible metabolic pathways.The metabolites were identified by extracted ion chromatograms using predicted m/z values as well as retention time,excimer ions,and fragmentation behavior.Overall,85 QYSLD-related xenobiotics(20 prototype compounds and 65 metabolites)were characterized from rat urine.The main metabolic reactions and elimination features of QYSLD included oxidation,reduction,decarboxylation,hydrolysis,demethylation,glucuronidation,sulfation,methylation,deglycosylation,acetylation,and associated combination reactions.Of the identified molecules,14 prototype compounds and 58 metabolites were slowly eliminated,thus accumulating in vivo over an extended period,while five prototypes and two metabolites were present in vivo for a short duration.Furthermore,one prototype and five metabolites underwent the process of“appearing-disappearing-reappearing”in vivo.Overall,the metabolic profile and characteristics of QYSLD in rat urine were determined,which is useful in elucidating the active components of the decoction in vivo,thus providing the basis for studying its mechanism of action. 展开更多
关键词 Qi-Yu-San-Long decoction Post-targeted screening strategy Dynamic metabolic profile UPLC-QTOF-MSE
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Laser-modified luminescence for optical data storage 认领 引用 被引量：3
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作者 Xin Wei Weiwei Zhao +3 位作者 Ting Zheng Junpeng Lü Xueyong Yuan Zhenhua Ni 《Chinese Physics B》 SCIE EI CAS CSCD 2022年第11期89-99,共11页
The yearly growing quantities of dataflow create a desired requirement for advanced data storage methods.Luminescent materials,which possess adjustable parameters such as intensity,emission center,lifetime,polarizatio... The yearly growing quantities of dataflow create a desired requirement for advanced data storage methods.Luminescent materials,which possess adjustable parameters such as intensity,emission center,lifetime,polarization,etc.,can be used to enable multi-dimensional optical data storage(ODS)with higher capacity,longer lifetime and lower energy consumption.Multiplexed storage based on luminescent materials can be easily manipulated by lasers,and has been considered as a feasible option to break through the limits of ODS density.Substantial progresses in laser-modified luminescence based ODS have been made during the past decade.In this review,we recapitulated recent advancements in laser-modified luminescence based ODS,focusing on the defect-related regulation,nucleation,dissociation,photoreduction,ablation,etc.We conclude by discussing the current challenges in laser-modified luminescence based ODS and proposing the perspectives for future development. 展开更多
关键词 laser luminescence data storage
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5-Demethylnobiletin and its major metabolites:efficient preparation and mechanism of their anti-proliferation activity in HepG2 cells 认领 引用 被引量：1
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作者 Yanping Xin Ting Zheng +7 位作者 Man Zhang Ruiqiang Zhang Siyue Zhu Dongli Li Denggao Zhao Yanyan Ma Chi-Tang Ho Qingrong Huang 《Food Science and Human Wellness》 SCIE CAS CSCD 2022年第5期1191-1200,共10页
5-Demethylnobile tin(5-DMN),a hydroxylated polymethoxyflavone(OH-PMF)identified in aged citrus peels,has demonstrated health benefiting effects in previous studies.5-DMN undergoes biotransformation in vivo,yielding 5,... 5-Demethylnobile tin(5-DMN),a hydroxylated polymethoxyflavone(OH-PMF)identified in aged citrus peels,has demonstrated health benefiting effects in previous studies.5-DMN undergoes biotransformation in vivo,yielding 5,3’-didemethylnobiletin(5,3’-DDMN),5,4’-didemethylnobiletin(5,4’-DDMN)and5,3’,4’-tridemethylnobiletin(5,3’,4’-TDMN).However,the anti-cancer effects of 5-DMN and its in vivo metabolites against HepG2 cells remain unclear.In this study,an efficient chemical synthetic method was developed to obtain 5-DMN and its 3 metabolites,and their molecular structures were confirmed by;H NMR and LC-MS.Cytotoxicity,cell cycle arrestment,apoptosis and caspase-3 expression were investigated to evaluate the anti-liver cancer effects of these OH-PMFs on HepG2 cells.The results showed that all 4 compounds inhibited the proliferation of HepG2 cells in a concentration-dependent manner.Their anti-proliferative activity was exerted through inducing G2/M phase arrestment,cell apoptosis and promoting expression of a key apoptotic protein called cleaved caspase-3.Our results indicated that 5,3’-DDMN and5,3’,4’-TDMN showed a stronger inhibitory activity on cell proliferation than 5-DMN,followed by 5,4’-DDMN.The expression of cleaved caspase-3 was the highest in cells treated with 5,4’-DDMN,implying that the apoptosis induced by other OH-PMFs might be mediated by other apoptotic execution proteins.Our research reveals the application potential and scientific evidence for the production and functionality of OH-PMFs. 展开更多
关键词 Hydroxylated polymethoxyflavones Chemical synthesis HepG2 Cell cycle Apoptosis
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circRNA及其调控动物骨骼肌发育研究进展 认领 引用 被引量：8
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作者 郑婷 甘麦邻 +5 位作者 沈林園 牛丽莉 郭宗义 王金勇 张顺华 朱砺 《遗传》 CAS CSCD 北大核心 2020年第12期1178-1191,共14页
环状RNA(circular RNA,circRNA)是一类反向剪接形成的闭合环状RNA分子,广泛存在于生物体内,近年来成为非编码RNA中的研究热点。骨骼肌在生物体中起到协调运动的作用,是维持体内正常代谢和内分泌的器官之一。随着测序技术和生物信息学分... 环状RNA(circular RNA,circRNA)是一类反向剪接形成的闭合环状RNA分子,广泛存在于生物体内,近年来成为非编码RNA中的研究热点。骨骼肌在生物体中起到协调运动的作用,是维持体内正常代谢和内分泌的器官之一。随着测序技术和生物信息学分析技术的发展,circRNA在动物骨骼肌发育中的功能和调控机制逐渐被揭示。本文就当前circRNA的分子调控机制类型、circRNA经典研究思路及功能研究方法以及circRNA参与骨骼肌正常发育与骨骼肌疾病发生调控的研究进展进行了综述,以期为进一步深入研究circRNA参与骨骼肌生长发育调控的遗传机制以及circRNA相关研究方法提供参考。 展开更多
关键词 环状RNA 骨骼肌发育 骨骼肌疾病 RNA测序
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界面水分子扩散对超高分子量聚乙烯摩擦学性能影响的反应分子动力学模拟研究 认领 引用 被引量：3
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作者 郑庭 谷靖萱 +1 位作者 程启昊 张会臣 《高分子学报》 SCIE CAS CSCD 北大核心 2024年第2期222-234,共13页
采用基于反应力场(ReaxFF)的分子动力学模拟方法,研究了摩擦界面水分子向超高分子量聚乙烯(UHMWPE)基体扩散和渗透的基本过程.分子模拟结果表明:摩擦过程中,水分子稳定吸附在Fe板表面,并与聚乙烯链形成分子内摩擦,使聚乙烯分子产生剪切... 采用基于反应力场(ReaxFF)的分子动力学模拟方法,研究了摩擦界面水分子向超高分子量聚乙烯(UHMWPE)基体扩散和渗透的基本过程.分子模拟结果表明:摩擦过程中,水分子稳定吸附在Fe板表面,并与聚乙烯链形成分子内摩擦,使聚乙烯分子产生剪切变形.当Fe板表面存在纳尺度外凸结构时,其在UHMWPE表面的耕犁作用更为显著,使摩擦界面的内摩擦力显著增加.当摩擦速度增加时,摩擦界面原子温度显著升高.在水润滑条件下,界面水分子逐渐扩散到UHMWPE基体中,引起相邻聚乙烯链之间的原子距离增加,这导致聚乙烯链之间的相互作用强度降低.此外,摩擦界面处还伴随着水分子中氢氧键断裂,并引起相应原子的电荷跃变.此时,水氧原子与Fe原子形成Fe―O化合物,且具有与Fe2O3相似的晶体结构.水分子扩散进入UHMWPE内时,还引起其周围聚乙烯分子的电荷发生改变,造成UHMWPE表层原子电荷分布不均匀. 展开更多
关键词 反应分子动力学模拟 超高分子量聚乙烯 水分子扩散 分子键断裂 电荷转移
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Molecular dynamics simulation of the flow mechanism of shear-thinning fluids in a microchannel 认领 引用 被引量：2
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作者 杨刚 郑庭 +1 位作者 程启昊 张会臣 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第4期516-525,共10页
Shear-thinning fluids have been widely used in microfluidic systems,but their internal flow mechanism is still unclear.Therefore,in this paper,molecular dynamics simulations are used to study the laminar flow of shear... Shear-thinning fluids have been widely used in microfluidic systems,but their internal flow mechanism is still unclear.Therefore,in this paper,molecular dynamics simulations are used to study the laminar flow of shear-thinning fluid in a microchannel.We validated the feasibility of our simulation method by evaluating the mean square displacement and Reynolds number of the solution layers.The results show that the change rule of the fluid system's velocity profile and interaction energy can reflect the shear-thinning characteristics of the fluids.The velocity profile resembles a top-hat shape,intensifying as the fluid's power law index decreases.The interaction energy between the wall and the fluid decreases gradually with increasing velocity,and a high concentration of non-Newtonian fluid reaches a plateau sooner.Moreover,the velocity profile of the fluid is related to the molecule number density distribution and their values are inversely proportional.By analyzing the radial distribution function,we found that the hydrogen bonds between solute and water molecules weaken with the increase in velocity.This observation offers an explanation for the shear-thinning phenomenon of the non-Newtonian flow from a micro perspective. 展开更多
关键词 molecular dynamics simulation non-Newtonian fluid microchannel shear-thinning
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魔芋葡甘聚糖水合层承载及润滑机理的分子动力学模拟 认领 引用
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作者 程启昊 郑庭 +1 位作者 杨刚 张会臣 《高分子学报》 SCIE CAS CSCD 北大核心 2023年第11期1784-1794,共11页
魔芋葡甘聚糖(KGM)溶液具有优良的承载和润滑能力,为研究其微观作用机理,采用分子动力学模拟的方法,阐明了魔芋葡甘聚糖水合层的形成过程,探讨其在模拟工况下(压力范围:0~1000 MPa、剪切速度范围:0.02~1 nm/ps)的承载能力及剪切特性,揭... 魔芋葡甘聚糖(KGM)溶液具有优良的承载和润滑能力,为研究其微观作用机理,采用分子动力学模拟的方法,阐明了魔芋葡甘聚糖水合层的形成过程,探讨其在模拟工况下(压力范围:0~1000 MPa、剪切速度范围:0.02~1 nm/ps)的承载能力及剪切特性,揭示了其润滑机理.模拟结果表明,魔芋葡甘聚糖分子与水分子通过氢键形成水合分子,由于吸附效应,水合分子向铁原子层表面吸附聚集构成水合层作为承压载体;在剪切作用下,界面处吸附的魔芋葡甘聚糖水合分子层削弱了水分子与铁原子层的相互作用,从而降低界面剪切应力;魔芋葡甘聚糖分子数过多时,液相层中间部位的魔芋葡甘聚糖浓度增加,造成其周围液相层流动阻力增大,导致界面剪切应力增大.随着剪切速度的增加,KGM与水分子间的氢键随之减弱,从而削弱了KGM水合分子对水分子的约束,导致界面剪切应力随剪切速度的增大而增大. 展开更多
关键词 分子动力学模拟 魔芋葡甘聚糖 承载机理 润滑机理
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蚕丝丝肽嗜热栖热菌发酵液对皮肤抗炎抗衰功效的增效作用 认领 引用 被引量：2
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作者 方婷欢 郑婷 +2 位作者 蒋晴 李晓霞 唐礼荣 《日用化学工业（中英文）》 CAS 北大核心 2023年第9期1057-1064,共8页
为研究嗜热栖热菌发酵的蚕丝丝肽在皮肤抗炎抗衰功效上的增效作用,以脂多糖(LPS)诱导的角质形成细胞(HaCaT细胞)和双氧水(H2O2)诱导的成纤维细胞(HDF细胞)为研究模型,通过比色法、酶联免疫吸附(ELISA)等方法检测蚕丝丝肽、嗜热栖热菌发... 为研究嗜热栖热菌发酵的蚕丝丝肽在皮肤抗炎抗衰功效上的增效作用,以脂多糖(LPS)诱导的角质形成细胞(HaCaT细胞)和双氧水(H2O2)诱导的成纤维细胞(HDF细胞)为研究模型,通过比色法、酶联免疫吸附(ELISA)等方法检测蚕丝丝肽、嗜热栖热菌发酵液和蚕丝丝肽发酵液对细胞活力、炎症因子白介素1β(IL-1β)和白介素6(IL-6)的含量、屏障保湿相关蛋白水通道蛋白3(AQP3)和丝聚蛋白(FLG)的含量、衰老相关标志物超氧化物歧化酶(SOD)、晚期糖基化终产物(AGEs)和人1型胶原蛋白(Col-1)的含量变化的影响。结果表明,蚕丝丝肽发酵液能够显著降低IL-1β,IL-6,AGEs含量,显著促进FLG,AQP3,SOD和Col-1表达,且相较于蚕丝丝肽能更显著抑制IL-6和AGEs表达,更显著促进HDF细胞迁移和SOD合成,而相较于嗜热栖热菌发酵液能更显著降低IL-1β,IL-6和AGEs表达,更显著促进AQP3表达、HDF细胞迁移和SOD的合成,即认为蚕丝丝肽发酵液相较于单一的蚕丝丝肽和嗜热栖热菌发酵液具备抗炎、屏障保湿及抗衰功效的增效作用。 展开更多
关键词 蚕丝丝肽 嗜热栖热菌 蚕丝丝肽发酵液 抗炎 抗衰 增效
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