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Protective effect of boric acid on kidney tissue and oxidative stress after testicular torsion/detorsion in male rats 认领 引用
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作者 Uğur M Adam Metin Alkan +2 位作者 Şaban C Sezen Mustafa Kavutçu Mustafa Arslan 《World Journal of Nephrology》 2026年第2期310-319,共10页
BACKGROUND Testicular ischemiaeperfusion(I/R)injury may affect distant organs.During I/R,metabolites formed in the affected organ are released into the circulation;thus,non-ischemic organs,such as the kidneys and lung... BACKGROUND Testicular ischemiaeperfusion(I/R)injury may affect distant organs.During I/R,metabolites formed in the affected organ are released into the circulation;thus,non-ischemic organs,such as the kidneys and lungs,become involved in the inflammatory process,even if they are not primarily affected.Damage from testicular torsion/detorsion(T/D)models has been shown to affect kidneys.There is a need to examine the nephroprotective effect of boric acid(BA),which is known to have antioxidant effects,on kidney damage.AIM To investigate kidney damage in a rat testicular T/D model and the effectiveness of BA on this distant organ damage.METHODS Twenty-four male Wistar albino rats were divided into four groups(n=6 each)-control(group C),BA(group BA),T/D(group I/R),BA-T/D(group BA-I/R).In all groups,the scrotum was cut longitudinally,and the testis was dissected.No medication was administered to groups C and group I/R.Groups BA and group BA-I/R were administered 50 mg/kg BA intraperitoneally half an hour before the surgical procedure.The testicular T/D model was applied to groups I/R and group BA-I/R.The malondialdehyde(MDA)level,catalase,glutathione S-transferase,and paraoxonase-1(PON-1)enzyme activities were measured in kidney tissue.Additionally,sections were taken and evaluated for histopathological examination.RESULTS An increase in MDA levels and a decrease in PON-1 activity were detected in the I/R group compared to the control group(P=0.001,P=0.002,respectively).MDA levels were found to be significantly lower in the BA-I/R group than in the I/R group(P=0.041).PON-1 enzyme activity was found to be significantly higher in the BA-I/R group than in the I/R group(P=0.048).The light microscopy examination showed an increase in glomerular vacuolization,tubular dilatation,vascular vacuolization and hypertrophy(VVH),and tubular cell degeneration and necrosis damage scores in the I/R group compared to the control group(P=0.003,P=0.005,P=0.008,and P<0.001,respectively).In the I/R group treated with BA,tubular dilatation and VVH scores decreased compared to the I/R group(P=0.037 and P=0.048,respectively).CONCLUSION These findings show that the testicular T/D model in rats causes kidney damage,and BA administration reduces this damage in the kidneys. 展开更多
关键词 Ischemiaeperfusion Torsion/detorsion Testis Kidney Boric acid Malondialdehyde Paraoxonase-1 Catalase Glutathione S-transferase Distant organ damage
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