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Exploring the correlation and mechanism of natural killer cell cytotoxic sensitivity against gastric cancer 认领 引用 被引量：1
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作者 WENZHUO YANG HAODONG CHEN +3 位作者 ZHILAN ZHANG ZHIYONG XIA YUANYUAN JIN ZHAOYONG YANG 《Oncology Research》 SCIE 2025年第6期1485-1494,共10页
Background:Human natural killer(NK)cells have attracted widespread attention as a potential adoptive cell therapy(ACT).However,the therapeutic effects of NK cell infusion in patients with solid tumors are limited.Ther... Background:Human natural killer(NK)cells have attracted widespread attention as a potential adoptive cell therapy(ACT).However,the therapeutic effects of NK cell infusion in patients with solid tumors are limited.There is an urgent need to explore a suitable new treatment plan to overcome weaknesses and support the superior therapeutic activity of NK cells.Methods:In this study,the mechanisms underlying the susceptibility of gastric cancer(GC)cell lines AGS,HGC-27,and NCI-N87 to NK cell-mediated cytotoxicity were explored.Results:Lactic dehydrogenase(LDH)release assays showed that all three GC cell lines were susceptible to the umbilical cord blood NK(UCB-NK)cells,and HGC-27 cells with high CD56 expression were the most sensitive to UCB-NK,followed by NCI-N87 and AGS.When the expression of CD56 in HGC-27 cells decreased,the lytic activity of NK cells in HGC-27 cells was abating.In addition,combining oxaliplatin with NK cells produced additive anti-tumor effects in vitro,which may have resulted from oxaliplatin-induced NK group 2 member D(NKG2DL)upregulation in GC cells.These results of cytotoxicity activity showed that inhibition of CD56 expression might suppress the sensitivity of GC cells to NK cell-mediated cytotoxicity,and upregulation of the expression of NKG2DL on the surface of GC cells by oxaliplatin could enhance the killing sensitivity of NK cells.Conclusion:Collectively,our study provides a deeper theoretical foundation and a better therapeutic strategy for NK cell immunotherapy in the treatment of human GC. 展开更多
关键词 Umbilical cord blood natural killer(UCB-NK)cells Oxaliplatin Gastric cancer Natural killer group 2 member D(NKG2D)ligand(NKG2DL) CD56(neural cell adhesion molecule NCAM)
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Continued evolution of H10N3 influenza virus with adaptive mutations poses an increased threat to mammals 认领 引用 被引量：4
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作者 Shiping Ding Jiangtao Zhou +8 位作者 Junlong Xiong Xiaowen Du Wenzhuo Yang Jinyu Huang Yi Liu Lihong Huang Ming Liao Jiahao Zhang Wenbao Qi 《Virologica Sinica》 SCIE CAS CSCD 2024年第4期546-555,共10页
The H10 subtype avian influenza virus(AIV)poses an ongoing threat to both birds and humans.Notably,fatal human cases of H10N3 and H10N8 infections have drawn public attention.In 2022,we isolated two H10N3 viruses(A/ch... The H10 subtype avian influenza virus(AIV)poses an ongoing threat to both birds and humans.Notably,fatal human cases of H10N3 and H10N8 infections have drawn public attention.In 2022,we isolated two H10N3 viruses(A/chicken/Shandong/0101/2022 and A/chicken/Shandong/0603/2022)from diseased chickens in China.Genome analysis revealed that these viruses were genetically associated with human-origin H10N3 virus,with internal genes originating from local H9N2 viruses.Compared to the H10N8 virus(A/chicken/Jiangxi/102/2013),the H10N3 viruses exhibited enhanced thermostability,increased viral release from erythrocytes,and accumulation of hemagglutinin(HA)protein.Additionally,we evaluated the pathogenicity of both H10N3 and H10N8 viruses in mice.We found that viral titers could be detected in the lungs and nasal turbinates of mice infected with the two H10N3 viruses,whereas H10N8 virus titers were detectable in the lungs and brains of mice.Notably,the proportion of double HA Q222R and G228S mutations in H10N3 viruses has increased since 2019.However,the functional roles of the Q222R and G228S double mutations in the HA gene of H10N3 viruses remain unknown and warrant further investigation.Our study highlights the potential public health risk posed by the H10N3 virus.A spillover event of AIV to humans could be a foretaste of a looming pandemic.Therefore,it is imperative to continuously monitor the evolution of the H10N3 influenza virus to ensure targeted prevention and control measures against influenza outbreaks. 展开更多
关键词 Avian influenza virus(AIV) H10N3 Evolution Pathogenicity
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Oncolytic virus M1 reinvigorates CD8+T-cell immunity against glioblastoma through B-cell-dependent antigen crosspresentation in the spleen 认领 引用 被引量：1
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作者 Yu Han Cui Guo +23 位作者 Chaoxin Chen Wenzhuo Yang Honghui Li Changjia He Jialin Deng Zhijie Chen Wenfeng Liu Jiehong Chen Yingqian Zhong Caixin Yan Cuiying Xu Xuanming Liang Sheng Zhong Furong Chen Depei Li Cong Li Wanming Hu Zhenghe Chen Yonggao Mou Zhongping Chen Guangmei Yan Michael Lim Wenbo Zhu Ke Sai 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2026年第4期349-366,共18页
Glioblastoma multiforme(GBM)is a lethal primary brain cancer with limited treatment options.Systemic and local immunosuppression induced by GBMs contributes to malignancy aggressiveness and resistance to immune checkp... Glioblastoma multiforme(GBM)is a lethal primary brain cancer with limited treatment options.Systemic and local immunosuppression induced by GBMs contributes to malignancy aggressiveness and resistance to immune checkpoint blockade(ICB)therapy.Herein,we demonstrated that a novel oncolytic virus,M1(OVM),reversed GBM-driven systemic immunosuppression and promoted T lymphocyte infiltration within the tumor microenvironment(TME).Intravenous administration of OVM suppressed glioma progression in a spleen-dependent manner.Mechanistically,OVM enhanced B-cell–T-cell interactions in the spleen through the formation of immune synapses.A subset of B cells positive for bone marrow stromal cell antigen 2(Bst2)was enriched in the splenic marginal zone following OVM treatment and exhibited superior capacity for antigen cross-presentation.These splenic Bst2+B cells activated cognate CD8+T cells to mediate adaptive antitumor immunity against intracranial gliomas.Moreover,OVM treatment synergized with anti-PD-1 therapy and further extended the survival of glioma-bearing animals.Collectively,our findings highlight the therapeutic potential of intravenous OVM for GBM management and reveal a novel immunomodulatory mechanism underlying oncolytic virotherapy. 展开更多
关键词 Glioma Oncolytic virus B cell Antigen cross-presentation
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