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3D printed composite scaffold accelerates bone regeneration by modulating immunity and promoting angiogenesis 认领 引用 被引量：1
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作者 Yiye Fan Jiaxin Yao +5 位作者 Wan Liu Lebin Wang Jing Yang Xiaoyan Zheng Junfeng Hui Daidi Fan 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2026年第1期1-18,共18页
Treating critical-size bone defects remains a significant clinical challenge,due to the complexity of achieving adequate immunomodulation,angiogenesis,osteogenic differentiation and matrix mineralization.Successful bo... Treating critical-size bone defects remains a significant clinical challenge,due to the complexity of achieving adequate immunomodulation,angiogenesis,osteogenic differentiation and matrix mineralization.Successful bone repair requires an orchestrated response in these areas to promote tissue integration and regeneration effectively.In this study,we designed and fabricated a customized,bioactive porous GDM/CeHA@CA scaffold through 3D printing and subsequent UV crosslinking techniques.The scaffold integrating Mn2+-chelated deferoxamine(DFO)-grafted gelatin methacryloyl(GDM)with citric acid-modified cerium-doped hydroxyapatite nanowires(CeHA@CA).The controlled Mn2+release from the scaffold strongly modulated macrophages polarization toward the anti-inflammatory M2 phenotype by down-regulating the MAPK signaling pathway and up-regulating the MnSOD signaling pathway.Macrophages maintain the stability of the bone microenvironment and prevent excessive inflammatory responses through immunomodulatory responses,and immunomodulated M2 macrophages promote angiogenesis and osteoblast differentiation by secreting growth factors VEGF and TGF-β.Scaffold degradation also led to the sustained release of covalently bound DFO,along with increased endogenous VEGF levels,promoted robust vascular remodeling.Additionally,the release of Ce3+/4+,as well as Ca2+and PO43−from CeHA@CA nanowires,in combination with elevated endogenous TGF-β,further boosted os-teogenesis.Therefore,GDM/CeHA@CA scaffolds are able to promote angiogenesis and osteogenic differentiation not only through direct degradation,but also indirectly through immunomodulation.Through these synergistic mechanisms of immunomodulation,angiogenesis,osteogenic differentiation and matrix mineralization,the GDM/CeHA@CA scaffold successfully accelerated the repair of the critical-size tibial bone defect in rabbits within 12 weeks.In conclusion,the 3D printed GDM/CeHA@CA composite scaffold provided a highly effective therapeutic strategy for rapid bone defects repair,making it a viable candidate for clinical applications in bone regeneration. 展开更多
关键词 3D printing Bone immunomodulation Angiogenesis Osteogenic differentiation Cerium hydroxyapatite nanowires
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Vortex Solitons in Atomic-Molecular Bose-Einstein Condensates with a Square-Optical-Lattice Potential 认领 引用 被引量：1
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作者 Yuan Zhao Wan Liu +5 位作者 Linjia Wang Zhuo Fan Qin Zhou Boris A.Malomed Shunfang Chen Siliu Xu 《Chinese Physics Letters》 SCIE EI CAS CSCD 2025年第9期7-13,共7页
We propose a theoretical framework,based on the two-component Gross-Pitaevskii equation(GPE),for the investigation of vortex solitons(VSs)in hybrid atomic-molecular Bose-Einstein condensates under the action of the st... We propose a theoretical framework,based on the two-component Gross-Pitaevskii equation(GPE),for the investigation of vortex solitons(VSs)in hybrid atomic-molecular Bose-Einstein condensates under the action of the stimulated Raman-induced photoassociation and square-optical-lattice potential.Stationary solutions of the coupled GPE system are obtained by means of the imaginary-time integration,while the temporal dynamics are simulated using the fourth-order Runge-Kutta algorithm.The analysis reveals stable rhombus-shaped VS shapes with topological charges m=1 and 2 of the atomic component.The stability domains and spatial structure of these VSs are governed by three key parameters:the parametric-coupling strength(χ),atomicmolecular interaction strength(g12),and the optical-lattice potential depth(V0).By varyingχand g12,we demonstrate a structural transition where four-core rhombus-shaped VSs evolve into eight-core square-shaped modes,highlighting the nontrivial nonlinear dynamics of the system.This work establishes a connection between interactions of cold atoms and topologically structured matter waves in hybrid quantum systems. 展开更多
关键词 atomic molecular Bose Einstein condensates vortex solitons fourth order Runge Kutta algorithm Gross Pitaevskii equation imaginary time integration square optical lattice potential vortex solitons vss temporal dynamics
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Controlling the conductivity and microporosity of biocarbon to produce supercapacitors with battery-level energies at an ultrahigh power 认领 引用
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作者 CHENG Bei XIE Xing-yan +5 位作者 WAN Liu CHEN Jian ZHANG Yan DU Cheng GUO Xue-feng XIE Ming-jiang 《新型炭材料（中英文）》 SCIE EI CAS CSCD 北大核心 2025年第2期409-420,共12页
In order to meet the demands of new-generation electric vehicles that require high power output(over 15 kW/kg),it is crucial to increase the energy density of car-bon-based supercapacitors to a level comparable to tha... In order to meet the demands of new-generation electric vehicles that require high power output(over 15 kW/kg),it is crucial to increase the energy density of car-bon-based supercapacitors to a level comparable to that of batteries,while maintaining a high power density.We re-port a porous carbon material produced by immersing pop-lar wood(PW)sawdust in a solution of KOH and graphene oxide(GO),followed by carbonization.The resulting mater-ial has exceptional properties as an electrode for high-en-ergy supercapacitors.Compared to the material prepared by the direct carbonization of PW,its electrical conductivity was in-creased from 0.36 to 26.3 S/cm.Because of this and a high microporosity of over 80%,which provides fast electron channels and a large ion storage surface,when used as the electrodes for a symmetric supercapacitor,it gave a high energy density of 27.9 Wh/kg@0.95 kW/kg in an aqueous electrolyte of 1.0 mol/L Na2SO4.The device also had battery-level energy storage with maximum energy densities of 73.9 Wh/kg@2.0 kW/kg and 67.6 Wh/kg@40 kW/kg,an ultrahigh power density,in an organic electrolyte of 1.0 mol/L TEABF4/AN.These values are comparable to those of 30−45 Wh/kg for Pb-acid batteries and 30−55 Wh/kg for aqueous lithium batteries.This work indicates a way to prepare carbon materials that can be used in supercapacit-ors with ultrahigh energy and power densities. 展开更多
关键词 Reduced GO modification Loose wood Symmetric supercapacitor Battery-level energy density
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CdS/Mg-CdIn2S4异质结构筑及CO2光还原性能研究 认领 引用
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作者 张燕 宋正宜 +3 位作者 万柳 杜成 解明江 陈建 《辽宁石油化工大学学报》 CAS 2025年第5期28-36,共9页
CdS在可见光区具有优异的光化学性能和高量子效率,但其光催化稳定性明显受光腐蚀限制,构筑CdS/Mg-CdIn2S4异质结可抑制光腐蚀并提升其光催化稳定性。采用离子交换法制备CdS纳米线(CdS NWs)、CdS纳米颗粒(CdS NPs)和Mg-CdIn2S_... CdS在可见光区具有优异的光化学性能和高量子效率,但其光催化稳定性明显受光腐蚀限制,构筑CdS/Mg-CdIn2S4异质结可抑制光腐蚀并提升其光催化稳定性。采用离子交换法制备CdS纳米线(CdS NWs)、CdS纳米颗粒(CdS NPs)和Mg-CdIn2S4纳米片(NSs),并构筑5%CdS NWs/Mg-CdIn2S4(5%为CdS NWs的质量分数)和5%CdS NPs/Mg-CdIn2S4(5%为CdS NPs的质量分数)异质结;通过XRD、UV-vis DRS、FT-IR光谱、N2吸脱附等温测试及瞬态光电流和电化学阻抗对光催化剂进行了表征。结果表明,CdS NWs/Mg-CdIn2S4和CdS NPs/Mg-CdIn2S4异质结成功构筑;在光反应系统对催化剂进行的性能评价中,二者均展现出良好的光催化CO2还原性能,其中CdS NWs/Mg-CdIn2S4展现出更为突出的光催化CO2还原性能,CO和H2的产率分别为716.7μmol/(g·h)和664.3μmol/(g·h),分别比Mg-CdIn2S4提高了46.2倍和56.8倍。研究结果为光催化CO2还原领域的深入研究和应用奠定了基础,具有重要的学术和实际意义。 展开更多
关键词 CdS/Mg-CdIn2S4 异质结构 光催化 CO2还原
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Degradation of pyrene by immobilized microorganisms in saline-alkaline soil 认领 引用 被引量：22
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作者 Shanxian Wang Xiaojun Li +5 位作者 Wan Liu Peijun Li Lingxue Kong Wenjie Ren Haiyan Wu Ying Tu 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2012年第9期1662-1669,共8页
Biodegradation of polycyclic aromatic hydrocarbons （PAHs） is very difficult in saline-alkaline soil due to the inhibition of microbial growth under saline-alkaline stress. The microorganisms that can most effectivel... Biodegradation of polycyclic aromatic hydrocarbons （PAHs） is very difficult in saline-alkaline soil due to the inhibition of microbial growth under saline-alkaline stress. The microorganisms that can most effectively degrade PAHs were screened by introducing microorganisms immobilized on farm byproducts and assessing the validity of the immobilizing technique for PAHs degradation in pyrene-contaminated saline-alkaline soil. Among the microorganisms examined, it was found that Mycobacterium sp. B2 is the best, and can degrade 82.2% and 83.2% of pyrene for free and immobilized cells after 30 days of incubation. The immobilization technique could increase the degradation of pyrene significantly, especially for fungi. The degradation of pyrene by the immobilized microorganisms Mucor sp. F2, fungal consortium MF and co-cultures of MB＋MF was increased by 161.7% （P 〈 0.05）, 60.1% （P 〈 0.05） and 59.6% （P 〈 0.05） after 30 days, respectively, when compared with free F2, MF and MB＋ME Scanning electron micrographs of the immobilized microstructure proved the positive effects of the immobilized microbial technique on pyrene remediation in saline- alkaline soil, as the interspace of the carder material structure was relatively large, providing enough space for cell growth. Co-cultures of different bacterial and fungal species showed different abilities to degrade PAHs. The present study suggests that Mycobacterium sp. B2 can be employed for in situ bioremediation of PAHs in saline-alkaline soil, and immobilization of fungi on farm byproducts and nutrients as carriers will enhance fungus PAil-degradation ability in saline-alkaline soil. 展开更多
关键词 saline-alkaline soil immobilization PAHs-degrading microorganisms biodegradation characteristics Mycobacterium
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Selective laser melting of near-αtitanium alloy Ti-6Al-2Zr-1Mo-1V:Parameter optimization,heat treatment and mechanical performance 认领 引用 被引量：28
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作者 Chao Cai Xu Wu +8 位作者 Wan Liu Wei Zhu Hui Chen Jasper Chu Dong Qiu Chen-Nan Sun Jie Liu Qingsong Wei Yusheng Shi 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2020年第22期51-64,共14页
This paper presents a comprehensive study conducted to optimize the selective laser melting(SLM)parameters and subsequent heat-treatment temperatures for near-αhigh-temperature titanium alloy Ti-6 Al-2 Zr-1 Mo-1 V(TA... This paper presents a comprehensive study conducted to optimize the selective laser melting(SLM)parameters and subsequent heat-treatment temperatures for near-αhigh-temperature titanium alloy Ti-6 Al-2 Zr-1 Mo-1 V(TA15),which is widely used in the aerospace industry.Based on the surface morphology and relative density analysis,the optimized process parameters were:laser power from 230 W to 380 W,scan speed from 675 mm/s to 800 mm/s,scan spacing of 0.12 mm,and layer thickness of0.03 mm.The effects of the laser power and the layer thickness on the phase constitutions,microstructure features,as well as room-temperature and high-temperature(500℃)tensile properties,were then studied to obtain an in-depth understanding of SLM-built TA15.Six typical temperatures(650,750,850,950,1000 and 1100℃)covering three representative temperature ranges,i.e.,martensite partial decomposition temperature range,martensite complete decomposition temperature range and aboveβtransus temperature,were subsequently selected as heat-treatment temperatures.The heat treatmentmicrostructure-mechanical property relationships of SLM-built TA15 were elucidated in detail.These results provide valuable information on the development of SLM-built TA15 alloy for industrial applications,and these findings are also beneficial to additive manufacturing of other near-αTi alloys with desirable high-temperature properties. 展开更多
关键词 Selective laser melting Near-αtitanium Heat treatment High-temperature tensile properties
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PEPT1-mediated prodrug strategy for oral delivery of peramivir 认领 引用 被引量：5
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作者 Yongbing Sun Wei Gan +7 位作者 Mingdao Lei Wei Jiang Meng Cheng Junwei He Qi Sun Wan Liu Lvjiang Hu Yi Jin 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2018年第6期555-565,共11页
Peramivir was a novel and highly potent neuraminidase(NA) inhibitor for the treatment of influenza A and B. However, it exhibited a very low oral bioavailability(only 3%) due to the high polarity(log P of-1.4) and the... Peramivir was a novel and highly potent neuraminidase(NA) inhibitor for the treatment of influenza A and B. However, it exhibited a very low oral bioavailability(only 3%) due to the high polarity(log P of-1.4) and the low membrane permeability across the intestine. To utilize the PEPT1-mediated prodrug strategy to improve the oral absorption and develop the oral alternative, seven amino acid ester prodrugs and seven amino acid amide prodrugs have been synthesized. The permeability of these prodrugs across Caco-2 cells were screened. Peramivr-(CH_2)_2-l-Val and Peramivir-l-Ile were of the highest permeability in ester prodrugs and amide prodrugs, respectively, and then they were selected for further studies. Glycylsarcosine(gly-sar) uptake by Caco-2 could be inbihited by Peramivir-(CH_2)_2-l-Val and Peramivir-l-Ile in a concentration-dependent manner, and the IC 50 was 1.34 ± 0.31 m M and 1.78 ± 0.48 m M, respectively. The direct uptake of Peramivir-(CH_2)_2-l-Val and Peramivirl-Ile in MDCK-PEPT1 cells were significantly higher than in MDCK mock cells, and could be markedly inhibited by gly-sar. The uptake of Peramivir-(CH_2)_2-l-Val and Peramivir-l-Ile(0.01 to 50 m M) in MDCK-hPEPT1 cells conformed to Michaelis–Menten Equation. The oral bioavailability of peramivir was 65.3% and 37.3% after the oral administration of Peramivir-(CH_2)_2-l-Val and Peramivir-l-Ile to rats, respectively. The oral absorption and bioactivation of Peramivir-(CH_2)_2-l-Val was rapid and extensive, and no Peramivir-(CH_2)_2-l-Val was found in plasma. Because the amide bond was relatively stable, Peramivir-l-Ile could not be totally converted to the parent drug in vivo. Peramivir-(CH_2)_2-l-Val with good oral profiles and rapid bioactivation might be a promising prodrug for the further clinic development. The present study also corroborated the idea that the PEPT1-mediated prodrug approach has enormous promise for improving the oral absorption of poorly absorbed drug. 展开更多
关键词 Peramivir Prodrug Peptide transporter 1 Pharmacokinetics Oral bioavailability
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Measurement of Secondary Electron Energy Spectra of Polymethyl Methacrylate 认领 引用 被引量：1
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作者 Ming Weng Wan Liu +2 位作者 Ming Yin Fang Wang Meng Cao 《Chinese Physics Letters》 SCIE EI CAS CSCD 2018年第4期108-112,共5页
We report on a novel and convenient method of measuring secondary electron spectra for insulators in a secondary electron yield measurement system with a planar grid analyzer configuration and a metal mesh probe. In t... We report on a novel and convenient method of measuring secondary electron spectra for insulators in a secondary electron yield measurement system with a planar grid analyzer configuration and a metal mesh probe. In this measurement, the planar grid is negatively biased to force some emitted secondary electrons to return to the sample surface and to neutralize charges accumulated on the sample during the previous beam irradiation. The surface potential of the sample is then measured by use of a metal mesh probe. The grid bias for neutralization corresponding to the zero surface potential is determined based on the linear relationship between the surface potential and the grid bias. Once the surface potential equals zero, the secondary electron spectra of polymethyl methacrylate（PMMA） are studied experimentally by measuring the -curve and then fitting it to Everhart＇s formula. The measurement results show that the peak energy and the full width at half maximum of the spectra are 4.26 eV and 14.06 eV, respectively. 展开更多
关键词 SE In Measurement of Secondary Electron Energy Spectra of Polymethyl Methacrylate
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Application of single-cell RNA sequencing in head and neck squamous cell carcinoma 认领 引用 被引量：4
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作者 Zhaohong An Wan Liu +2 位作者 Wenbin Li Minghui Wei Changming An 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2023年第4期331-342,共12页
Single-cell RNA sequencing has been broadly applied to head and neck squamous cell carcinoma(HNSCC) for characterizing the heterogeneity and genomic mutations of HNSCC benefiting from the advantage of single-cell reso... Single-cell RNA sequencing has been broadly applied to head and neck squamous cell carcinoma(HNSCC) for characterizing the heterogeneity and genomic mutations of HNSCC benefiting from the advantage of single-cell resolution. We summarized most of the current studies and aimed to explore their research methods and ideas, as well as how to transform them into clinical applications. Through single-cell RNA sequencing, we found the differences in tumor cells’ expression programs and differentiation tracks. The studies of immune microenvironment allowed us to distinguish immune cell subpopulations, the extensive expression of immune checkpoints, and the complex crosstalk network between immune cells and non-immune cells. For cancerassociated fibroblasts(CAFs), single-cell RNA sequencing had made an irreplaceable contribution to the exploration of their differentiation status, specific CAFs markers, and the interaction with tumor cells and immune cells. In addition, we demonstrated in detail how single-cell RNA sequencing explored the HNSCC epithelial-tomesenchymal transition(EMT) model and the mechanism of drug resistance, as well as its clinical value. 展开更多
关键词 Single-cell RNA sequencing head and neck squamous cell carcinoma intra-tumoral heterogeneity immune infiltration epithelial-to-mesenchymal transition drug resistance
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Influence of the anisotropy on the magneto-acoustic response of magnetic surface acoustic wave resonators 认领 引用
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作者 Yawei Lu Wenbin Hu +1 位作者 Wan Liu Feiming Bai 《Chinese Physics B》 SCIE EI CAS CSCD 2020年第6期494-498,共5页
One-port magnetic surface acoustic wave(MSAW) resonators are fabricated by stacking multilayered(FeCoSiB/SiO2)n films directly on top of interdigital electrodes. It is shown that the magneto-acoustic response of the M... One-port magnetic surface acoustic wave(MSAW) resonators are fabricated by stacking multilayered(FeCoSiB/SiO2)n films directly on top of interdigital electrodes. It is shown that the magneto-acoustic response of the MSAW resonators critically depends the hysteresis of △E effect. For the magnetic multilayer without induced magnetic anisotropy, the resonance frequency( fR) exhibits a butterfly-like dependence on the external field, therefore, enabling bipolar detection of magnetic field smaller than its coercive field. However, for the magnetic multilayers with induced magnetic anisotropy, butterfly-like or loop-like fR–H curves are measured along the interdigtial electrode fingers or the SAW propagation direction, which can be attributed to the competition between the magnetic field-induced anisotropy and the stress-induced or shape anisotropy. 展开更多
关键词 surface acoustic wave magnetic field sensor magnetoelastic property
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SysFinder:A customized platform for search,comparison and assisted design of appropriate animal models based on systematic similarity 认领 引用
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作者 Shuang Yang Guoqing Zhang +6 位作者 Wan Liu Zhen Wang Jifeng Zhang Dongshan Yang Y.Eugene Chen Hong Sun Yixue Li 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2017年第5期251-258,共8页
Animal models are increasingly gaining values by cross-comparisons of response or resistance to clinical agents used for patients.However,many disease mechanisms and drug effects generated from animal models are not t... Animal models are increasingly gaining values by cross-comparisons of response or resistance to clinical agents used for patients.However,many disease mechanisms and drug effects generated from animal models are not transferable to human.To address these issues,we developed SysFinder（http：//lifecenter.sgst.cn/SysFinder）,a platform for scientists to find appropriate animal models for translational research.SysFinder offers a ＂topic-centered＂ approach for systematic comparisons of human genes,whose functions are involved in a specific scientific topic,to the corresponding homologous genes of animal models.Scientific topic can be a certain disease,drug,gene function or biological pathway.SysFinder calculates multi-level similarity indexes to evaluate the similarities between human and animal models in specified scientific topics.Meanwhile,SysFinder offers species-specific information to investigate the differences in molecular mechanisms between humans and animal models.Furthermore,SysFinder provides a userfriendly platform for determination of short guide RNAs（sgRNAs） and homology arms to design a new animal model.Case studies illustrate the ability of SysFinder in helping experimental scientists.SysFinder is a useful platform for experimental scientists to carry out their research in the human molecular mechanisms. 展开更多
关键词 Database Animal models Function similarity
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Application of Clinical Nursing Pathway Combined with Cluster Nursing Mode in Biologic Treatment of Rheumatoid Immune Disease Patients 认领 引用
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作者 Li Wang Wan Liu Yanrui Ren 《Yangtze Medicine》 2022年第3期76-82,共7页
Objective: To investigate the effect of clinical nursing pathway (CNP) combined with cluster nursing mode in intravenous biologic treatment of rheumatoid immune disease patients. Methods: Convenience sampling method w... Objective: To investigate the effect of clinical nursing pathway (CNP) combined with cluster nursing mode in intravenous biologic treatment of rheumatoid immune disease patients. Methods: Convenience sampling method was used to select inpatients receiving biologics treatment in Rheumatology and Immunology Department of a grade A hospital in Jingzhou city from May 2020 to April 2022. 75 patients from May 2020 to April 2021 were selected as the control group, and 75 patients from May 2021 to April 2022 were selected as the observation group. The control group was given routine care. The observation group was treated with CNP combined with cluster nursing mode on the basis of the control group, and the incidences of adverse infusion reactions, total treatment time, patient satisfaction and nurse satisfaction were compared between the two groups. Results: There were statistically significant differences between the two groups after intervention (P Conclusion: Using CNP combined with cluster nursing mode is beneficial to reduce the incidence of adverse infusion reactions in patients, shorten the total treatment time, and improve the satisfaction of patients and nurses. 展开更多
关键词 Biologic Treatment Clinical Nursing Pathway Cluster Nursing Rheumatoid Immune Disease
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基于深海采矿过程的环境影响分析与管理对策建议 认领 引用 被引量：17
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作者 刘大海 万浏 +1 位作者 王春娟 李成龙 《海洋科学进展》 CAS CSCD 北大核心 2022年第3期367-378,共12页
深海矿产开发所产生的环境影响是目前制约深海采矿的重要问题之一,了解开发全过程的环境影响和生态响应是商业化开采的前提。本文以多金属结核、富钴结壳和多金属硫化物三种具有代表性的深海固体矿产资源为例,分析了开发前赋存环境、开... 深海矿产开发所产生的环境影响是目前制约深海采矿的重要问题之一,了解开发全过程的环境影响和生态响应是商业化开采的前提。本文以多金属结核、富钴结壳和多金属硫化物三种具有代表性的深海固体矿产资源为例,分析了开发前赋存环境、开发过程中及开发后的环境影响。结果表明:①不同深海固体矿产资源的分布规律、深度以及生物特征等赋存环境存在较大差异,因采矿活动带来的赋存环境改变、对环境的影响以及采矿潜在影响区域、影响时长和恢复潜力也有所不同。②多金属结核开采的环境影响着重考虑了沉积物羽流的影响,结壳开采活动从沉积物扰动、外壳去除以及栖息地改变三个方面考虑环境影响,多金属硫化物开采的环境影响还要增加对有毒物质的释放以及栖息地移除两个方面的考虑。③深海采矿对底栖生物种群的数量和物种组成皆会造成不同程度的影响。最后,从持续跟进监测评估、充实数据、提升采矿技术与设备、顶层设计与决策管理、规则制定等方面提出了环境保护与可持续发展对策建议,为深海采矿的环境影响评价及规则制定提供参考。 展开更多
关键词 深海矿产资源 多金属结核 富钴结壳 多金属硫化物 环境影响
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LiFePO4锂离子动力电池45℃容量衰减机理 认领 引用 被引量：6
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作者 张凯博 徐晓明 +4 位作者 薛有宝 万柳 田威 曾涛 张亚婷 《化工学报》 EI CSCD 北大核心 2021年第10期5396-5401,共6页
以电动汽车的方型LiFePO4/石墨动力实验电池为研究对象,探究其在45℃恒温箱下1C充放电循环的失效机理。通过对电池进行解剖,系统分析了电池循环前后正负极片的厚度、形貌、结构和克容量的变化。随着电池在45℃高温下循环,电解液分解... 以电动汽车的方型LiFePO4/石墨动力实验电池为研究对象,探究其在45℃恒温箱下1C充放电循环的失效机理。通过对电池进行解剖,系统分析了电池循环前后正负极片的厚度、形貌、结构和克容量的变化。随着电池在45℃高温下循环,电解液分解以及Fe溶出损失、SEI膜再生长,消耗大量的活性锂,交流内阻增加导致电化学极化增大,活性锂消耗引起负极容量损失为6.7%,负极结构变化造成的容量损失为22.64%。结果表明石墨负极动力学性能的衰减是电池失效的主要因素。 展开更多
关键词 动力电池 磷酸铁锂 电化学 动力学 膜
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Research Progress of Humanistic Care Nursing 认领 引用 被引量：2
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作者 Li Wang Wan Liu 《Open Journal of Nursing》 2022年第9期633-641,共9页
This paper summarizes the literature on the concept of humanistic care nursing, the research status of humanistic care nursing curriculum education and nursing practice at home and abroad, in order to provide referenc... This paper summarizes the literature on the concept of humanistic care nursing, the research status of humanistic care nursing curriculum education and nursing practice at home and abroad, in order to provide reference and basis for humanistic care training and education. 展开更多
关键词 Humanistic Care Nursing Research Progress
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涂炭铝箔对高能量密度LiFePO4动力电池的影响 认领 引用 被引量：6
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作者 张凯博 贾凯丽 +4 位作者 徐晓明 曾涛 薛有宝 万柳 赵宗良 《储能科学与技术》 CAS CSCD 北大核心 2022年第12期3741-3747,共7页
探究不同涂炭层的涂炭铝箔对高能量密度磷酸铁锂(LiFePO4)动力电池的影响,以石墨+炭黑(GC)和炭黑(C)两种涂炭体系的涂炭铝箔制作的磷酸铁锂软包电池作为研究对象,评估了两种不同涂炭层对锂离子电池电化学性能的影响。物性对比结果显... 探究不同涂炭层的涂炭铝箔对高能量密度磷酸铁锂(LiFePO4)动力电池的影响,以石墨+炭黑(GC)和炭黑(C)两种涂炭体系的涂炭铝箔制作的磷酸铁锂软包电池作为研究对象,评估了两种不同涂炭层对锂离子电池电化学性能的影响。物性对比结果显示,GC方案外观为深灰色,石墨与炭黑复合后具有大孔径的蓬松状结构,而C方案外观为黑色,由纳米级炭黑颗粒组成,呈现小孔径疏松状结构。结果显示GC复合涂炭层的黏结力为炭黑涂层的1.18倍。电化学性能结果表明,两种方案的首次库仑效率和放电平台一致性高,而GC方案的电荷转移阻抗更小。GC方案复合涂炭层更有利于提高电池的常温和高温循环性能,而C方案炭黑涂炭层可改善电池的大倍率和低温性能。 展开更多
关键词 锂离子电池 磷酸铁锂 涂炭铝箔
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噪声暴露对大鼠代谢组学的影响 认领 引用 被引量：4
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作者 吉佳慧 苗龙 +4 位作者 万柳 孙蓉丽 张娟 尹立红 浦跃朴 《环境与职业医学》 CAS CSCD 北大核心 2020年第5期433-439,共7页
[背景]诸多研究证实噪声暴露与听力损失、高血压等健康损害相关,而目前关于噪声暴露的代谢组学研究鲜有报道。[目的]探索噪声暴露对Wistar大鼠的健康效应以及噪声暴露相关的大鼠血清及尿液代谢产物的改变。[方法]8周龄雄性Wistar大鼠随... [背景]诸多研究证实噪声暴露与听力损失、高血压等健康损害相关,而目前关于噪声暴露的代谢组学研究鲜有报道。[目的]探索噪声暴露对Wistar大鼠的健康效应以及噪声暴露相关的大鼠血清及尿液代谢产物的改变。[方法]8周龄雄性Wistar大鼠随机分为噪声暴露组(10只)和对照组(8只)。暴露组大鼠给予85 d B声压级的宽带噪声暴露,每天8 h,每周5 d,共计6周。暴露周期结束后,分别测量大鼠的体重、脏器质量和血压,通过听性脑干反应(ABR)测定大鼠的听力状况,并进行血生化检查。收集两组大鼠的血清和尿液,应用高分辨四级杆飞行时间质谱仪进行非靶向代谢组学研究,分析噪声暴露引起的小分子代谢产物表达的变化及相关代谢通路。[结果]噪声暴露对大鼠的体重、脏器系数和血压无明显影响(P> 0.05)。暴露组大鼠在32 k Hz处的ABR阈值为(74.00±5.48)d B,高于对照组[(55.00±3.54)d B](P 0.05)。血清代谢组学研究筛选并鉴定了27种噪声暴露相关的差异代谢物,涉及甘油磷脂代谢、亚油酸代谢和类固醇代谢等通路。尿液代谢组学研究筛选并鉴定了18种差异代谢物,涉及脂类代谢、苯丙氨酸代谢和色氨酸代谢等通路。[结论]噪声暴露可影响大鼠听力阈值和血脂水平,同时可引起血清和尿液中小分子代谢物表达改变,干扰甘油磷脂代谢、亚油酸代谢、苯丙氨酸代谢等代谢通路。 展开更多
关键词 噪声暴露 听力损失 心血管系统 代谢组学
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己内酰胺原位开环聚合改性LiMn0.8Fe0.2PO4正极材料 认领 引用 被引量：3
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作者 杨楠 郭隆泉 +3 位作者 任丽 万柳 徐琳 祝天喜 《稀有金属》 EI CAS CSCD 北大核心 2020年第10期1045-1052,共8页
以水/乙二醇为溶剂,采用溶剂热法制备了LiMn0.8Fe0.2PO4(LMFP)正极材料,尝试在溶剂热过程中加入不同含量的己内酰胺(CL),利用其在一定温度水解后于LMFP晶体表面完成原位开环聚合反应,达到限制LMFP粒径的目的。以葡萄糖为碳源经球磨及煅... 以水/乙二醇为溶剂,采用溶剂热法制备了LiMn0.8Fe0.2PO4(LMFP)正极材料,尝试在溶剂热过程中加入不同含量的己内酰胺(CL),利用其在一定温度水解后于LMFP晶体表面完成原位开环聚合反应,达到限制LMFP粒径的目的。以葡萄糖为碳源经球磨及煅烧过程对LMFP进行碳包覆,得到LMFP-CL/C正极材料。通过纳米粒度分析仪、X射线衍射(XRD)、扫描电镜(SEM)和透射电镜(TEM)对其结构与形貌进行表征,利用充放电测试、循环伏安及交流阻抗对其电化学性能进行表征。结果表明:相比于LMFP/C样品,当己内酰胺的添加量为0.04 mol时,所得的LMFP-CL0.04/C样品平均粒径由274.8 nm减小至171.6 nm,该材料在0.2C,0.5C,1.0C,2.0C,5.0C和10.0C倍率下的放电比容量分别达到164.3,158.4,144.8,133.7,104.8和69.6 mAh·g-1,较LMFP/C分别提高了12.4%,20.2%,18.8%,29.9%,81.9%和86.8%。LMFPCL0.04/C样品在1 C下经循环100次后放电比容量衰减至133.7 mAh·g-1,容量保持率为92.3%。己内酰胺的加入减小了LMFP的颗粒大小,缩短了Li+的传输通道,使材料的电化学性能得以提升。 展开更多
关键词 LiMn0.8Fe0.2PO4 己内酰胺 溶剂热法 原位开环聚合 正极材料
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生物元件库国内外研究进展 认领 引用 被引量：2
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作者 刘婉 严兴 +2 位作者 沈潇 张国庆 周志华 《微生物学报》 CAS CSCD 北大核心 2021年第12期3774-3782,共9页
生物元件库是对元件数据和实物进行收集、整理和共享的重要平台,对合成生物学的研究和应用具有非常重要的支撑作用。本文对国内外生物元件库的研究进展进行了介绍和综述。国外先后出现了标准生物元件登记库等多个元件库,通过制定Open MT... 生物元件库是对元件数据和实物进行收集、整理和共享的重要平台,对合成生物学的研究和应用具有非常重要的支撑作用。本文对国内外生物元件库的研究进展进行了介绍和综述。国外先后出现了标准生物元件登记库等多个元件库,通过制定Open MTA协议实现了元件实物的免费分发共享,并通过制定"合成生物学开放语言"(SBOL)实现了多个元件库之间的数据交换;通过bionet项目对元件数据和实物的去中心化管理作了进一步尝试。近年来我们与国内多家科研单位合作建设了合成生物学元件与数据库(RDBSB,http://gffzzc63ccd718860418fs505956fkq9ov6p05.ffgz.tsg.suse.edu.cn/or http://gffzz371e7e38e3a64bdds505956fkq9ov6p05.ffgz.tsg.suse.edu.cn/)。在建设过程中,我们首先建立了与SBOL语言兼容的《催化元件数据标准》、多种重要元件的标准功能测试方法以及安全高效的元件提交系统,并在此基础上完成了元件数量最多且信息最为全面的催化元件数据库的构建。目前,收集了30多万个催化元件,包括7万多个具有文献支持功能表征信息的催化元件,并保藏了1万个以上的实物元件和5000个底盘菌株,通过网站实现了数据和实物的公开与共享。上述元件库已经对国内合成生物学的研究和应用产生了积极地推动作用,访问量超过100万次/年,提供元件和底盘共享服务大于100次/年,并为多家企业和研究单位提供了元件和底盘的定制服务。虽然我们的元件库建设取得了巨大的进步,但是仍需在调控元件的收集整理和共享机制创新等方面取得更多的突破,在数据有源、多层审核、资源共享、信息公开、信息安全和授权访问的基础上,加速生物元件数据、实物和设计工具的汇聚,并进一步服务合成生物学研究。 展开更多
关键词 元件库 合成生物学 共享机制 催化元件 调控元件
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基于Logistic回归的外阴上皮内瘤变危险度评价模型的构建 认领 引用 被引量：2
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作者 金钰铌 李亚敏 +2 位作者 刘菀 许静 鲁潇凝 《中国现代医学杂志》 CAS 北大核心 2021年第15期36-41,共6页
目的应用临床资料和流行病学资料建立外阴上皮内瘤变危险度评价模型。方法模型样本为101例外阴上皮内瘤变患者、134例外阴良性病变者及150例外阴完全正常者。对其临床资料和流行病学资料进行单因素分析,通过受试者工作特征(ROC)曲线获... 目的应用临床资料和流行病学资料建立外阴上皮内瘤变危险度评价模型。方法模型样本为101例外阴上皮内瘤变患者、134例外阴良性病变者及150例外阴完全正常者。对其临床资料和流行病学资料进行单因素分析,通过受试者工作特征(ROC)曲线获取影响因素的截断值,构建Logistic回归模型,采用混淆矩阵回代分析验证模型的正确率。结果经Logistic回归分析,年龄、吸烟、人类乳头瘤病毒(HPV)感染、外阴瘙痒、外阴触血、外阴肿物、外阴疼痛、绝经与否、中性粒细胞绝对值(GRA)、中性粒细胞与淋巴细胞的比值(NLR)、血清糖类抗原125(CA125)指标进入回归方程。回归模型最大似然比(LR)检验具有差异(P<0.05)。混淆矩阵回代分析结果发现该模型总体预测正确率为78.44%(302/385)。结论应用临床资料和流行病学资料构建外阴上皮内瘤变危险度评价模型,能有效提高外阴上皮内瘤变正确筛查率。 展开更多
关键词 外阴上皮内瘤变 早期筛查 Logistic回归 危险度评价
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