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Electroacupuncture at ST36 protects against dextran sulfate sodium-induced ulcerative colitis in mice by enhancing sympathetic nerve innervation in colonic tissue 认领 引用
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作者 Dongfeng Zhao Yuquan Yang +8 位作者 Junhao Liang Chuanglong Xu Chunlan Tang Mingming Zhang Chenguang Li Yongjian Zhao Bing Shu Wei Gou Yongjun Wang 《MedScience》 SCIE CAS CSCD 2026年第1期164-172,共9页
Ulcerative colitis(UC),characterized by diffuse colonic inflammation and enteric nervous system(ENS)alterations,remains a therapeutic challenge.While the role of the parasympathetic nervous system in intestinal inflam... Ulcerative colitis(UC),characterized by diffuse colonic inflammation and enteric nervous system(ENS)alterations,remains a therapeutic challenge.While the role of the parasympathetic nervous system in intestinal inflammation has been extensively documented,understanding of sympathetic nervous system(SNS)function in UC pathogenesis remains limited.Electroacupuncture(EA)at ST36(Zusanli)is a widely used alternative therapy for UC,yet its regulatory effects on the ENS-—particularly the SNS—and the underlying mechanisms remain unclear.Here,we established a 2.5%dextran sulfate sodium(DSS)-induced murine UC model and validated disease phenotypes via histological assessment.Using a non-anesthetic EA intervention protocol mimicking the clinical conditions,we found that EA at ST36 attenuated local inflammatory progression in DSS-induced UC mice and mitigated ENS degeneration.Critically,our results demonstrated that EA at ST36 specifically reversed SNS reduction(tyrosine hydroxylase-positive,TH+neurons)in colonic tissue caused by intestinal inflammation.In conclusion,this study reveals that EA at ST36 restores colonic homeostasis through a sympathetic-dependent mechanism,providing novel insights and therapeutic strategies for the clinical management of UC. 展开更多
关键词 electroacupuncture ST36(Zusanli) anti-inflammation ulcerative colitis sympathetic nerve systems
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An analytical equation for predicting corrosion rates of biodegradable Zn-0.45Mn-0.2Mg alloy via symbolic regression 认领 引用
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作者 Shanpeng Zhao Wei Gou +3 位作者 Zhangzhi Shi Lichen Li Haijun Zhang Luning Wang 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2026年第6期2016-2028,I0026-I0034,共13页
Corrosion rates of biodegradable Zn alloys are directly related to their post-implantation safety and effectiveness.However,highly accurate and interpretable“white-box”machine learning models for predicting their co... Corrosion rates of biodegradable Zn alloys are directly related to their post-implantation safety and effectiveness.However,highly accurate and interpretable“white-box”machine learning models for predicting their corrosion rates remain largely unexplored.This study proposes a data-driven method coupled with accelerated corrosion testing for predicting the corrosion rates of biodegradable Zn-0.45Mn-0.2Mg(wt%)alloy.A symbolic regression(SR)machine-learning model was established based on an analytical expression of the corrosion rate and four corrosion parameters.Outperforming five other machine-learning models,the SR model achieved a determ-ination coefficient of 0.97 and prediction errors in the verification experiments of less than 10%.This study contributes to a paradigm shift from qualitative to quantitative analysis for corrosion research on biodegradable metals. 展开更多
关键词 symbolic regression corrosion rate accelerated corrosion zinc alloys
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Achieving quadruple performance enhancement in biodegradable Zn-Fe alloys via accumulative cooling and interface fusion(ACIF) 认领 引用
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作者 Wei Gou Qiang Wang +5 位作者 Zhang-Zhi Shi Yuman Zhu Jia-You Zhang Shan-Peng Zhao Hai-Jun Zhang Lu-Ning Wang 《Rare Metals》 SCIE EI CAS CSCD 2025年第12期10887-10900,共14页
Theoretically,cooling rate decreases exponentially as solidification thickness increases.This leads to coarse second-phase particles in Zn alloys,which not only impairs mechanical properties but also exacerbates degra... Theoretically,cooling rate decreases exponentially as solidification thickness increases.This leads to coarse second-phase particles in Zn alloys,which not only impairs mechanical properties but also exacerbates degradation nonuniformity.To address this common issue,we have developed accumulative-cooling and interface-fusion(ACIF) technology that maintains a high cooling rate regardless of increased solidification thickness.Using Zn-0.4Fe as a model alloy,the accumulative-cooling process achieves an average cooling rate of 817℃ min-1,approximately 68 times that of air cooling.After extrusion,the average size of FeZn13 particles is refined from 29.4 to 0.4 μm,reaching the highest level of refinement in Zn alloys.As a result,a quadruple enhancement of Zn-0.4Fe model alloy has been achieved:Ultimate tensile strength enhanced 1.6-fold to 265 MPa(the highest among Zn-Fe alloys),elongation enhanced from 29% to 48%,corrosion uniformity improved 3 times,and cell viability of mouse embryonic osteoblast precursor cells(MC3T3-E1)increased by 20%.A long rod is obtained via ACIF,overcoming the limitation that fast-cooled Zn alloys could only be produced in thin plate form.This enables the possibility of fabricating bone screws and vascular stents using bulk Zn alloys with fine second-phase particles.From a technical standpoint,this technique can be widely applied to a variety of metallic materials. 展开更多
关键词 Biodegradable Zn alloys Microstructure refinement Mechanical properties Corrosion uniformity Cell viability
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Research on the panel adjustment method of an active main reflector for a large radio telescope 认领 引用 被引量：6
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作者 Zheng-Xiong Sun Jin-Qing Wang +2 位作者 Lin-Feng Yu Wei Gou Guang-Li Wang 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2021年第2期105-112,共8页
The surface accuracy of a large parabolic antenna is an important indicator to evaluate the quality of the antenna.It not only directly affects the antenna’s aperture efficiency,thereby determining the shortest wavel... The surface accuracy of a large parabolic antenna is an important indicator to evaluate the quality of the antenna.It not only directly affects the antenna’s aperture efficiency,thereby determining the shortest wavelength that the antenna can work,but also affects the main lobe width and side lobe structure of the antenna pattern.Microwave holography is an important method for parabolic antenna profile detection.In this article we adopt a new algorithm to adjust the panels for the large radio telescope with an active main reflector through the TM65 m antenna’s aperture phase profile.The panels of the TM65 m radio telescope is in a radial pattern with 14 rings.Each corner of the panel is fixed on the screw of the actuator to move up and down,and the adjacent corners of the four panels share an actuator.We use the method of plane fitting to calculate the adjustment value of every panel’s corner.But one actuator,which simultaneously controls the common corner of the adjacent panels,will have different adjustment values according to the different plane fitting equation based on adjacent panels.In this paper,the adjustment value of the adjacent panels’crosspoints are constrained to be equal to the constraint condition to calculate each actuator’s adjustment value of the TM65 m radio telescope.Through multiple adjustments and application of the new algorithms,the accuracy of the TM65 m antenna reflector profile has been improved from the original 0.28 mm to the current 0.19 mm. 展开更多
关键词 microwave holography-radio astronomy-surface deviation-least squares method
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Thermal Analysis of the Backup Structure of the Tianma Telescope 认领 引用 被引量：4
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作者 Li Fu Lin-Feng Yu +5 位作者 Jian-Sen Tang Bing-En Yang Wei Gou Jin-Qing Wang Qing-Hui Liu Zhi-Qiang Shen 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2022年第10期119-128,共10页
Taking the Tianma Radio Telescope(TMRT)as an object,this paper focuses on the determination of temperature gradients and thermal deformations of the backup structure(BUS)with the finite element method.To this end,a mo... Taking the Tianma Radio Telescope(TMRT)as an object,this paper focuses on the determination of temperature gradients and thermal deformations of the backup structure(BUS)with the finite element method.To this end,a modeling and analysis method,which consists of a simplified FEM and a four-component simulation process,is proposed.In the development,only solar radiation is considered and thermal convection is neglected.Based on the thermal time constant of the BUS,the simulations of temperature gradients are simplified as static analysis.The superposed temperature gradients agree well with the ones measured by thermometers with a 0.57℃ root mean square(rms)error.In addition,the illuminated-weighted rms errors of the primary reflector surface calculated by the simulation and measured by the extended out-of-focus holography are in good agreement.The rms error increases approximately 170μm when the Sun persistently illuminated the BUS for 3 hr.The optimized initial temperature of the antenna structure is 20℃ by comparing the results between the finite element analysis and the e-OOF measurement.The thermal deformation database can support the real-time compensation of the active surface system if the traces of the radio telescope are known in advance. 展开更多
关键词 Astronomical Instrumentation-Methods and Techniques-telescopes-methods analytical
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Research on actuator distribution and panels for a radio telescope 认领 引用 被引量：1
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作者 Jin-Qing Wang Zheng-Xiong Sun +9 位作者 Li Fu Jin-Ling Li Lin-Feng Yu Yong-Chen Jiang Yong-Bin Jiang Wei Gou Wei Hu Rong-Bin Zhao Qin-Hui Liu Zhi-Qiang Shen 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2021年第7期31-36,共6页
Trying to achieve the best surface accuracy control with the fewest actuators, this article mainly studies the distribution of actuators and the method of panel design. The influence of the number of faulty actuators ... Trying to achieve the best surface accuracy control with the fewest actuators, this article mainly studies the distribution of actuators and the method of panel design. The influence of the number of faulty actuators on the accuracy of the surface shape is demonstrated. In addition, the method incorporating a triangular panel, node index and the fitting solution method of a single panel is also given. This method provides a reference for the design and realization of an active surface or a deformable sub-reflector for high performance large aperture radio telescopes. 展开更多
关键词 radio telescope triangle panel method design
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A Q-band two-beam cryogenic receiver for the Tianma Radio Telescope 认领 引用 被引量：1
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作者 Wei-Ye Zhong Jian Dong +11 位作者 Wei Gou Lin-Feng Yu Jin-Qing Wang Bo Xia Wu Jiang Cong Liu Hui Zhang Jun Shi Xiao-Xing Yin Sheng-Cai Shi Qing-Hui Liu Zhi-Qiang Shen 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2018年第4期77-90,共14页
A Q-band two-beam cryogenic receiver for the Tianma Radio Telescope（TMRT）has been developed,and it uses the independently-developed key microwave and millimeter-wave components operating from 35 to 50 GHz with a fra... A Q-band two-beam cryogenic receiver for the Tianma Radio Telescope（TMRT）has been developed,and it uses the independently-developed key microwave and millimeter-wave components operating from 35 to 50 GHz with a fractional bandwidth of 35%.The Q-band receiver consists of three parts：optics,cold unit assembly and warm unit assembly,and it can receive simultaneously the lefthanded and right-handed circularly polarized waves.The cold unit assembly of each beam is composed of a feed horn,a noise injection coupler,a differential phase shifter,an orthomode transducer and two low-noise amplifiers,and it works at a temperature range near 20 K to greatly improve the detection sensitivity of the receiving system.The warm unit assembly includes four radio-frequency amplifiers,four radio-frequency high-pass filters,four waveguide biased mixers,four 4–12 GHz intermediate-frequency amplifiers and one 31–38 GHz frequency synthesizer.The measured Q-band four-channel receiver noise temperatures are roughly 30–40 K.In addition,the single-dish spectral line and international very long baseline interferometry（VLBI）observations between the TMRT and East Asia VLBI Network at the Q-band have been successfully carried out,demonstrating the advantages of the TMRT equipped with the state-of-the-art Q-band receiver. 展开更多
关键词 telescopes — instrumentation interferometers — methods observational
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Firsekibart versus compound betamethasone in acute gout patientsunsuitable for standard therapy: A randomized phase 3 trial 认领 引用 被引量：9
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作者 Yu Xue Tianshu Chu +15 位作者 Jiankang Hu Wei Gou Ning Zhang Juan Li Jing Yu Rongping Li Rongbin Li Long Qian Xinwang Duan Lihua Duan Xu Zhang Yuling Lian Yi Li Chuang Qi Dongzhe Huang Hejian Zou 《The Innovation》 EI 2025年第8期30-37,29,共8页
This phase 3 trial evaluated the efficacy and safety of Firsekibart,a novel,fully human anti-interleukin-1βmonoclonal antibody,in patients with frequent acute gout flares unsuitable for standard therapy.Pa-tients wer... This phase 3 trial evaluated the efficacy and safety of Firsekibart,a novel,fully human anti-interleukin-1βmonoclonal antibody,in patients with frequent acute gout flares unsuitable for standard therapy.Pa-tients were randomized(1:1,stratified by baseline pain visual analog scale[VAS])to the Firsekibart(200 mg)or compound betamethasone(CB;7 mg)group.Co-primary endpoints included change in pain inten-sity in the target joint at 72 h(non-inferiority testing)and time to first new flare within 12 weeks(superiority testing).The non-inferiority margin was 10 mm.The full analysis set included 311 patients(Firseki-bart:N=156;CB:N=155).At 72 h,the least squares mean change in pain VAS scores from baseline was-57.09 mm(95%confidence in-terval[CI]:-60.08 to-54.10)for Firsekibart and-53.77 mm(95%CI:-56.77 to-50.77)for CB,with treatment difference of-3.32 mm(95%CI:-7.56 to 0.91),establishing non-inferiority.The median time to first new flare was not reached within 12 weeks in the Firsekibart group compared with 45.0 days(95%CI:28.00 to 63.00)in the CB group.Firsekibart significantly reduced the risk of new flare by 90%vs.CB(haz-ard ratio:0.10;95%CI:0.06 to 0.17;stratified log rank p<0.0001).Effi-cacy was consistent across subgroups.Treatment-emergent adverse events occurred in 71.2%of Firsekibart-treated patients and 69.9%of those receiving CB.In conclusion,Firsekibart is effective and well toler-ated for acute gout flares in patients unsuitable for standard therapy,demonstrating non-inferiority in rapid pain relief and significant superi-ority in preventing flare compared with CB. 展开更多
关键词 compound betamethasone cb firsekibart non inferiority change pain standard therapypa tients pain visual analog scale vas compound betamethasone acute gout
Reinterpreting the phylogenetic position and taxonomic revision of the genus Pterocyclus(Apiaceae,Apioideae)based on nrITS,complete plastid genome,and morphological evidence 认领 引用
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作者 Xian-Lin Guo Wei Gou +4 位作者 Megan Price Qiu-Ping Jiang Chang Peng Song-Dong Zhou Xing-Jin He 《Journal of Systematics and Evolution》 SCIE CAS CSCD 2024年第3期384-402,共19页
The classification of species in the genus Pterocyclus has been a topic of concern,as they were initially considered members of Pleurospermum(Apiaceae)in the Flora of China.However,the intergeneric and infrageneric cl... The classification of species in the genus Pterocyclus has been a topic of concern,as they were initially considered members of Pleurospermum(Apiaceae)in the Flora of China.However,the intergeneric and infrageneric classifications of Pterocyclus and its allies,such as Hymenidium and Pleurospermum,have been controversial.To address these issues,we performed phylogenetic analyses using one nuclear marker(nrITS)from 167 accessions,including 137 species(including five species of Pterocyclus),and 105 plastid genes from 82 accessions representing 82 species(including five species of Pterocyclus)of Apiaceae.We used both maximum likelihood and Bayesian approaches to deduce phylogenetic relationships of Pterocyclus and its allies.Furthermore,we conducted morphometric analyses that specifically targeted the mericarp morphology,and compared the structural differences in their plastid genomes.Based on these findings,we suggest the following revisions to the classification of Pterocyclus and its allies:(i)Pterocyclus should encompass five species(Pterocyclus angelicoides,Pterocyclus forrestii,Pterocyclus rotundatus,Pterocyclus tibeticus,and Pterocyclus wolffianus),all of which are all monophyletic and placed in the Komarovieae;(ii)Pterocyclus rivulorum shows both phylogenetic and mericarp morphological similarities to Hymenidium apiolens and Hymenidium dentatum,which belongs to the Hymenidium Clade,thus we provisionally transfer it to Hymenidium;(iii)Pleurospermum longicarpum is considered conspecific with Pterocyclus angelicoides based on morphological descriptions in the Flora Xizangica;(iv)we describe and illustrate Pterocyclus tibeticus as a new species;and(v)Pterocyclus wolffianus should be recognized as a valid species and not considered a synonym of Pterocyclus forrestii. 展开更多
关键词 Apiaceae morphology phylogeny plastid genome Pleurospermum Pterocyclus taxonomy
East Asian VLBI Network observations of active galactic nuclei jets:imaging with KaVA+Tianma+Nanshan 认领 引用
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作者 Yu-Zhu Cui Kazuhiro Hada +74 位作者 Motoki Kino Bong-Won Sohn Jongho Park Hyun-Wook Ro Satoko Sawada-Satoh Wu Jiang Lang Cui Mareki Honma Zhi-Qiang Shen Fumie Tazaki Tao An Ilje Cho Guang-Yao Zhao Xiao-Peng Cheng Kotaro Niinuma Kiyoaki Wajima Ying-Kang Zhang Noriyuki Kawaguchi Juan-Carlos Algaba Shoko Koyama Tomoya Hirota Yoshinori Yonekura Nobuyuki Sakai Bo Xia Yong-Bin Jiang Lin-Feng Yu Wei Gou Ju-Yeon Hwang Yong-Chen Jiang Yun-Xia Sun Dong-Kyu Jung Hyo-Ryoung Kim Jeong-Sook Kim Hideyuki Kobayashi Jee-Won Lee Jeong-Ae Lee Hua Zhang Guang-Hui Li Zhi-Qiang Xu Peng Li Jung-Hwan Oh Se-Jin Oh Chung-Sik Oh Tomoaki Oyama Duk-Gyoo Roh Katsunori-M.Shibata Wen Guo Rong-Bing Zhao Wei-Ye Zhong Jin-Qing Wang Wen-Jun Yang Hao Yan Jae-Hwan Yeom Bin Li Xiao-Fei Li Jian-Ping Yuan Jian Dong Zhong Chen Kazunori Akiyama Keiichi Asada Do-Young Byun Yoshiaki Hagiwara Jeffrey Hodgson Tae-Hyun Jung Kee-Tae Kim Sang-Sung Lee Kunwoo Yi Qing-Hui Liu Xiang Liu Ru-Sen Lu Masanori Nakamura Sascha Trippe Na Wang Xue-Zheng Wang Bo Zhang 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2021年第8期220-234,共15页
The East Asian Very Long Baseline Interferometry(VLBI) Network(EAVN) is a rapidly evolving international VLBI array that is currently promoted under joint efforts among China,Japan and Korea.EAVN aims at forming a joi... The East Asian Very Long Baseline Interferometry(VLBI) Network(EAVN) is a rapidly evolving international VLBI array that is currently promoted under joint efforts among China,Japan and Korea.EAVN aims at forming a joint VLBI Network by combining a large number of radio telescopes distributed over East Asian regions.After the combination of the Korean VLBI Network(KVN) and the VLBI Exploration of Radio Astrometry(VERA) into Ka VA,further expansion with the joint array in East Asia is actively promoted.Here we report the first imaging results(at 22 and 43 GHz) of bright radio sources obtained with Ka VA connected to Tianma 65-m and Nanshan 26-m Radio Telescopes in China.To test the EAVN imaging performance for different sources,we observed four active galactic nuclei(AGN) having different brightness and morphology.As a result,we confirmed that the Tianma 65-m Radio Telescope(TMRT) significantly enhances the overall array sensitivity,a factor of 4 improvement in baseline sensitivity and 2 in image dynamic range compared to the case of Ka VA only.The addition of the Nanshan 26-m Radio Telescope(NSRT) further doubled the east-west angular resolution.With the resulting high-dynamic-range,high-resolution images with EAVN(Ka VA+TMRT+NSRT),various fine-scale structures in our targets,such as the counter-jet in M87,a kink-like morphology of the 3 C 273 jet and the weak emission in other sources are successfully detected.This demonstrates the powerful capability of EAVN to study AGN jets and to achieve other science goals in general.Ongoing expansion of EAVN will further enhance the angular resolution,detection sensitivity and frequency coverage of the network. 展开更多
关键词 galaxies:active galaxies:jets instrumentation:interferometers radio continuum:galaxies
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Machine learning design of 400 MPa grade biodegradable Zn-Mn based alloys with appropriate corrosion rates 认领 引用 被引量：5
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作者 Wangzhang Chen Wei Gou +6 位作者 Yageng Li Xiangmin Li Meng Li Jianxin Hou Xiaotong Zhang Zhangzhi Shi Luning Wang 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2024年第12期2727-2736,共10页
The commonly used trial-and-error method of biodegradable Zn alloys is costly and blindness.In this study,based on the self-built database of biodegradable Zn alloys,two machine learning models are established by the ... The commonly used trial-and-error method of biodegradable Zn alloys is costly and blindness.In this study,based on the self-built database of biodegradable Zn alloys,two machine learning models are established by the first time to predict the ultimate tensile strength(UTS)and immersion corrosion rate(CR)of biodegradable Zn alloys.A real-time visualization interface has been established to design Zn-Mn based alloys;a representative alloy is Zn-0.4Mn-0.4Li-0.05Mg.Through tensile mechanical properties and immersion corrosion rate tests,its UTS reaches 420 MPa,and the prediction error is only 0.95%.CR is 73μm/a and the prediction error is 5.5%,which elevates 50 MPa grade of UTS and owns appropriate corrosion rate.Finally,influences of the selected features on UTS and CR are discussed in detail.The combined application of UTS and CR model provides a new strategy for synergistically regulating comprehens-ive properties of biodegradable Zn alloys. 展开更多
关键词 Zn alloys machine learning alloy design performance prediction
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Correlation Study Between T Lymphocyte Subsets and Rheumatoid Arthritis 认领 引用
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作者 Wei Gou 《Journal of Clinical and Nursing Research》 2024年第7期178-183,共6页
Objective:To study the effect of Helicobacter pylori infection on rheumatoid arthritis and T-lymphocyte subpopulations in patients with rheumatoid arthritis and to provide a new method for the treatment of rheumatoid ... Objective:To study the effect of Helicobacter pylori infection on rheumatoid arthritis and T-lymphocyte subpopulations in patients with rheumatoid arthritis and to provide a new method for the treatment of rheumatoid arthritis by removing Helicobacter pylori from patients.Methods:60 patients with rheumatoid arthritis admitted to the hospital from May 2022 to May 2023 were selected for the study,and all patients underwent a 13-carbon urea breath test to detect gastric H.pylori and the test results showed that 20 cases were negative and 40 cases were positive.The 40 positive patients were divided into the treatment group(n=20)and non-treatment group(n=20)by random number table method and the treatment group was given anti-Helicobacter pylori treatment,and the non-treatment group was given maintenance rheumatoid basic treatment,comparing the anti-cyclic citrulline peptide(CCP),DS28 score,peripheral blood T-lymphocyte subsets(CD4+T-lymphocytes,CD8+T-lymphocytes,CD4+/CD8+ratio)before and after the treatment of patients by 13-carbon urea respiration test(pylori-negative group,20 patients)and those who were positive for the treatment of H pylori(pylori-positive group,40 patients).Besides,the correlation of peripheral blood T-lymphocyte subsets and disease activity between treatment and non-treatment groups in the pylori-positive group was identified together with the correlation of DS28 scores,TNF-αlevels,sedimentation and immunoglobulin,lymphocyte subsets in the pylori-positive treatment group and positive non-treatment group as well as the level of globulin,lymphocyte subsets,and peripheral blood lymphocytes before and after treatment.Results:Before treatment,CCP,DS28 score,CD8+T lymphocyte level of the pylori-negative group were lower than that of the positive group,and CD4+T lymphocyte and CD4+/CD8+ratio were higher than that of the positive group(P0.05);the positive treatment group had a DS28(3.19±1.02)points,positive non-treatment group DS28(5.36±1.85)points,non-treatment group DS28 score and CD4+T lymphocytes,CD4+/CD8+negative correlation with CD8+T lymphocytes showed a positive correlation(P0.05);after treatment,DS28 score,TNF-αlevel,CD8+T of the treatment group were lower than those of the non-treatment group,and CD4+T lymphocytes and CD4+/CD8+ratio were higher than those of the non-treatment group(P<0.05).Conclusion:H.pylori affects the level of T lymphocyte subsets in patients with rheumatoid arthritis,and there is a certain correlation between the two.Removal of H.pylori can improve the level of T lymphocyte subsets,which is important for the treatment of patients with rheumatoid arthritis. 展开更多
关键词 Peripheral blood T lymphocyte subsets Rheumatoid arthritis Helicobacter pylori Intestinal flora dysbiosis
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gBRCA1 and gBRCA2 mutations in specific different domains affect ovarian cancer prognosis:A multicenter retrospective study 认领 引用
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作者 Yingying Zhu Yingying Wang +9 位作者 Zhen Shen Lina Shen Hanyuan Liu Libing Xiang Xinya Huang Wei Gou Mengyun Wang Rongyu Zang Ying Zhou Tingyan Shi 《Chinese Medical Journal》 SCIE CAS CSCD 2026年第12期1829-1837,共9页
Background:The prognostic value of germline BRCA1/2 mutations(gBRCA1/2m)in ovarian cancer is controversial,and the clinical implications of specific mutation domains within BRCA1/2 remain underexplored.This study aime... Background:The prognostic value of germline BRCA1/2 mutations(gBRCA1/2m)in ovarian cancer is controversial,and the clinical implications of specific mutation domains within BRCA1/2 remain underexplored.This study aimed to investigate the impact of distinct gBRCA1/2m domains on survival outcomes in patients with ovarian cancer.Methods:This multicenter retrospective study,conducted between 2010 and 2022 at three major academic centers in China,analyzed 313 patients with epithelial ovarian cancer with pathogenic gBRCA1/2m.We evaluated associations between gBRCA1/2m domains and clinical outcomes including progression-free survival(PFS)and platinum-free interval.Results:Patients who received platinum-based chemotherapy without maintenance therapy with BRCA1 C-terminal domain 1(BRCT1)mutations showed significantly prolonged PFS(37.8 vs.22.6 months;hazard ratio[HR],0.43;95%confidence interval[CI],0.19–0.99;P=0.042),whereas those with Really Interesting New Gene(RING)mutations had shorter PFS(13.1 vs.23.2 months;HR,1.82;95%CI,0.89–3.72;P=0.097).In the subgroup of gross residual disease,RING mutations were significantly associated with reduced PFS(12.9 vs.21.8 months;HR,3.25;95%CI,1.29–8.18;P=0.008).A higher likelihood of primary platinum-refractory disease(odds ratio,7.78;95%CI,1.25–48.31;P=0.028)was observed.Across all mutation locations,poly(ADP-ribose)polymerase inhibitor(PARPi)maintenance therapy demonstrated benefits,notably for patients with BRCA1 RING mutations(HR,0.10;95%CI,0.01–0.84;P=0.010)and BRCA2 RAD51-binding domain(RAD51-BD)mutations(HR,0.29;95%CI,0.11–0.79;P=0.010).Conclusions:BRCA1 BRCT1 mutations are associated with improved prognosis following platinum-based chemotherapy,whereas BRCA1 RING domain mutations are linked to a heightened risk of primary platinum-refractory disease.Our findings underscore the need for complete resection with no gross residual disease in patients harboring RING mutations.Furthermore,PARPi maintenance therapy exhibits variable efficacy based on mutation location,with BRCA1 RING and BRCA2 RAD51-BD mutations conferring significant benefits. 展开更多
关键词 gBRCA1/2 mutation Ovarian cancer Mutation domain Poly(ADP-ribose)polymerase inhibitor Sensitivity to platinum BRCA RING Gross residue disease
Highly plastic Zn-0.3Ca alloy for guided bone regeneration membrane:Breaking the trade-off between antibacterial ability and biocompatibility 认领 引用 被引量：3
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作者 Xiang-Min Li Zhang-Zhi Shi +3 位作者 Ayisulu Tuoliken Wei Gou Chang-Heng Li Lu-Ning Wang 《Bioactive Materials》 SCIE CSCD 2024年第12期550-572,共23页
A common problem for Zn alloys is the trade-off between antibacterial ability and biocompatibility.This paper proposes a strategy to solve this problem by increasing release ratio of Ca2+ions,which is realized by s... A common problem for Zn alloys is the trade-off between antibacterial ability and biocompatibility.This paper proposes a strategy to solve this problem by increasing release ratio of Ca2+ions,which is realized by significant refinement of CaZn13 particles through bottom circulating water-cooled casting(BCWC)and rolling.Compared with conventionally fabricated Zn-0.3Ca alloy,the BCWC-rolled alloy shows higher antibacterial abilities against E.coli and S.aureus,meanwhile much less toxicity to MC3T3-E1 cells.Additionally,plasticity,degradation uniformity,and ability to induce osteogenic differentiation in vitro of the alloy are improved.The elongation up to 49%,which is the highest among Zn alloys with Ca,and is achieved since the sizes of CaZn13 particles and Zn grains are small and close.As a result,the long-standing problem of low formability of Zn alloys containing Ca has also been solved due to the elimination of large CaZn13 particles.The BCWC-rolled alloy is a promising candidate of making GBR membrane. 展开更多
关键词 Biodegradable Zn alloys Second phase refinement High plasticity Antibacterial ability Biocompatibility
Multi-objective optimization of three mechanical properties of Mg alloys through machine learning 认领 引用 被引量：8
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作者 Wei Gou Zhang-Zhi Shi +4 位作者 Yuman Zhu Xin-Fu Gu Fu-Zhi Dai Xing-Yu Gao Lu-Ning Wang 《Materials Genome Engineering Advances》 2024年第3期83-95,共13页
Conventional trial-and-error method is usually time-consuming and expensive for multi-objective optimization of Mg alloys.Although machine learning exhibits great potential to accelerate related research studies,machi... Conventional trial-and-error method is usually time-consuming and expensive for multi-objective optimization of Mg alloys.Although machine learning exhibits great potential to accelerate related research studies,machine learning prediction of properties of Mg alloys is often a prediction of a single target at a time.To address this,this paper integrates non-dominated sorting genetic algorithm III multiobjective optimization algorithm with light gradient boosting machine algorithm to simultaneously optimize yield strength,ultimate tensile strength,and elongation of Mg alloys.This is the first time that simultaneous machine learning optimization of these three objectives has been achieved for Mg alloys. 展开更多
关键词 alloy design machine learning Mg alloys multi-objective optimization
One-year status of hepatic venous pressure gradient measurement from 85 hospitals in China 认领 引用
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作者 Jitao Wang Ting Cui +87 位作者 Linpeng Zhang Zhiping Yan Lei Li Jinjun Chen Junhui Sun Hua Xiang He Zhu Hao Wu Jiancuo Gengzang Feng Zhang Wei Wu Guohong Cao Wuhua Guo Haibin Shi Hui Xue Guangjun Huang Qiang Yu Meng Niu Huiling Xiang Derun Kong Wei Gou Xuefeng Luo Fuliang He Min Yuan Wei Liu Yong Wang Hongjie Hu Xiaoli Zhu Tao Yu Qinxue Sun Wei Qu Ting Lu Deqiang Ma Li Zhang Jun Ma Jun Yang Ketao Mu Xiaoliang Zhu Kai Xiong Huiguo Ding Shengjuan Yao Mingsheng Huang Fang Wang Zexin Wang Yong Huang Jianan Li Hongfeng Yi Birun Huang Zhongwei Zhao Duiping Feng Yanming Lei Changlong Hou Wenbo Guo Shirong Liu Gaojun Teng Kangshun Zhu Fan Wu Xiaogang Hu Wenfeng Zhang Shaoqi Yang Zhouchao Hu Pengfei Pang Shaowu Zhuang Weidong Wang Qingliang Zhu Kunpeng Zhang Chengyu Liu Dongliang Li Chao Ma Hong Jiang Xingong Zhao Weixin Ren Zhiwei Wang Lei Yu Fuhuang Lin Chaoguang Yan Feng Wang Lei Yu Hui Huan Wenyong Shen Shaofei He Chengda Zhang Jinlun Bao Jiangtao Liu Jun Wu Jianbo Zhao Jian Zhang Xiaolong Qi 《Portal Hypertension & Cirrhosis》 2024年第2期116-123,共8页
Aims:Surveys and research on the applications of the hepatic venous pressure gradient(HVPG)are important for understanding the current status and future development of this technology in China.This article aimed to in... Aims:Surveys and research on the applications of the hepatic venous pressure gradient(HVPG)are important for understanding the current status and future development of this technology in China.This article aimed to investigate the status of hepatic venous pressure gradient measurement in China in 2022.Methods:We investigated the overall status of HVPG technology in China-including hospital distribution,hospital level,annual number of cases,catheters used,average cost,indications,and current challenges by using online questionnaire.By counting the number and percentages of cases of these results,we hope to clarify the current status of HVPG measurements in China.Results:According to the survey,85 hospitals in China used HVPG technology in 2022 distributed across 29 provinces.A total of 4989 HVPG measurements were performed in all of the surveyed hospitals in 2022,of which 2813 cases(56.4%)were measured alone.The average cost of HVPG measurement was 5646.8±2327.9 CNY.Of the clinical teams who performed the measurements(sometimes multiple per hospital),94.3%(82/87)used the balloon method,and the majority of the teams(72.4%,63/87)used embolectomy catheters.Conclusions:This survey clarified the clinical application status of HVPG in China and confirmed that some medical institutions in China have established a foundation for this technology.It is still necessary to continue promoting and popularizing this technology in the future. 展开更多
关键词 application status hepatic vein pressure gradient questionnaire survey
Tonifying Shen-Yin and-Yang Principles in Treating Osteoporosis: All Roads Lead to Rome 认领 引用 被引量：2
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作者 Wei Gou Nan-Mei Liu +4 位作者 Cheng-Long Wang Hui-Ling Wang Shi Lu Dong-Feng Zhao Xiu-Zhi Yu 《World Journal of Traditional Chinese Medicine》 CAS 2016年第4期38-48,共11页
Tonifying Shen strategy works as an important alternative and complementary method that is widely used to treat osteoporosis in Traditional Chinese Medicine(TCM) based on the proper identification of Zheng. Shen defic... Tonifying Shen strategy works as an important alternative and complementary method that is widely used to treat osteoporosis in Traditional Chinese Medicine(TCM) based on the proper identification of Zheng. Shen deficiency Zheng is one of the main types of osteoporosis while Shen-Yin and-Yang deficiencies represent two basic principlesypes of Shen deficiency. Currently, Tonifying Shen strategy, in particular, the Tonifying Shen-Yin and-Yang principles, has been demonstrated to exert osteoprotective effects. However, the mechanisms by which Tonifying Shen strategy and/or Tonifying Shen-Yin and-Yang principles function in treating osteoporosis are still not clearly understood. Here we first briefly explore current understanding of Tonifying Shen strategy, such as Tonifying Shen prescriptions, herbs, and effective components, in treating osteoporosis. Furthermore, the mechanism of Tonifying Shen-Yang principle in treating osteoporosis is reviewed from the clinic experience, animal, and mechanistic investigation. Moreover, the mechanisms by which Tonifying Shen-Yin principle in treating osteoporosis are established. Finally, we compare the similarity and difference between Tonifying Shen-Yang and-Yin principles in treating osteoporosis.Our findings indicate that both principles exert bone-protective effects in treating osteoporosis by simultaneously stimulating the differentiation of mesenchymal stem cells(MSCs) into osteoblast and the differentiation of hematopoietic stem cells(HSCs) into osteoclast. However,Tonifying Shen-Yin principle is in favor of increasing bone mineral density(BMD) while Tonifying Shen-Yang principle is in favor of osteoporosis-related syndromes. Our findings indicate that Tonifying Shen-Yin and-Yang principles not only share some similarity but also obtain some difference in treating osteoporosis. 展开更多
关键词 Osteoporosis Shen-Yin and-Yang Deficiency Tonifying Shen-Yin and-Yang Osteoclast Osteoblast
How heterogeneous susceptibility and recovery rates affect the spread of epidemics on networks 认领 引用 被引量：1
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作者 Wei Gou Zhen Jin 《Infectious Disease Modelling》 2017年第3期353-367,共15页
In this paper,an extended heterogeneous SIR model is proposed,which generalizes the heterogeneous mean-field theory.Different from the traditional heterogeneous mean-field model only taking into account the heterogene... In this paper,an extended heterogeneous SIR model is proposed,which generalizes the heterogeneous mean-field theory.Different from the traditional heterogeneous mean-field model only taking into account the heterogeneity of degree,our model considers not only the heterogeneity of degree but also the heterogeneity of susceptibility and recovery rates.Then,we analytically study the basic reproductive number and the final epidemic size.Combining with numerical simulations,it is found that the basic reproductive number depends on the mean of distributions of susceptibility and disease course when both of them are independent.If the mean of these two distributions is identical,increasing the variance of susceptibility may block the spread of epidemics,while the corresponding increase in the variance of disease course has little effect on the final epidemic size.It is also shown that positive correlations between individual susceptibility,course of disease and the square of degree make the population more vulnerable to epidemic and avail to the epidemic prevalence,whereas the negative correlations make the population less vulnerable and impede the epidemic prevalence. 展开更多
关键词 Networks Heterogeneity Susceptibility Recovery rates Correlation The basic reproductive number The final epidemic size
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