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AI-assisted design of 3 D-printed prosthesis for integrated replacement of the hip,femur,and knee caused by osseous hydatidosis 认领 引用 被引量：1
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作者 Yanlong Han Haoyuan Lei +7 位作者 Ruozhen Jia Wei Zhao Habaxi Kaken Deli Wang Yongsheng Liu Zhen Tan Li Wang Changchun Zhou 《Bio-Design and Manufacturing》 SCIE EI CAS CSCD 2026年第1期94-99,I0017,共6页
Cases of widespread bone hydatid infection are relatively rare in clinical practice.In this study,we reported for the first time a validated integrated repair therapy for multiple bone tissues,including the hip,femur,... Cases of widespread bone hydatid infection are relatively rare in clinical practice.In this study,we reported for the first time a validated integrated repair therapy for multiple bone tissues,including the hip,femur,and knee,caused by echinococ cosis.Artificial intelligence(AI)was used to develop a targeted surgical plan and to design a personalized prosthesis.Finite element analysis(FEA)was used to optimize the mechanical effectiveness of a customized integrated replacement prosthesis and to model stress distribution in the surrounding bone.Three-dimensional(3 D)printing was used to fabricate a customized prosthesis.With the assistance of AI,FEA,and 3 D printing technology,a personalized surgical plan and customized prosthesis were successfully constructed based on the patient’s disease.This approach achieved a successful therapeutic effect,demonstrating that AI-assisted personalized medicine holds great promise for the future. 展开更多
关键词 develop targeted surgical plan optimize mechanical effectiveness AI assisted design D printed prosthesis design personalized prosthesisfinite element analysis fea bone tissuesincluding bone hydatid infection integrated repair therapy
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Kdf1 missense mutation caused enamel defects by disrupting cell adhesion and Hippo-YAP signaling in dental epithelium 认领 引用
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作者 Pei Li Runling Zeng +6 位作者 Jingyan Xue Yaling Song Jie Wu Binghui Zeng Ling Lin Dongsheng Yu Wei Zhao 《International Journal of Oral Science》 SCIE CAS CSCD 2026年第3期561-572,共12页
Amelogenesis imperfecta is a hereditary enamel defect arising from dental epithelium dysfunction.Although keratinocyte differentiation factor 1(KDF1)acts as an intracellular regulator in epithelial cells,the underlyin... Amelogenesis imperfecta is a hereditary enamel defect arising from dental epithelium dysfunction.Although keratinocyte differentiation factor 1(KDF1)acts as an intracellular regulator in epithelial cells,the underlying disease mechanism of the patient-derived KDF1 missense mutation in amelogenesis remains unclear.Here,we show that a patient-derived KDF1 mutation(c.908 G>C,p.R303P)causes enamel defects by disrupting cell adhesion and Hippo-YAP signaling.Immunohistochemistry revealed strong KDF1 expression throughout dental epithelium development,particularly at the cell membrane.Kdf1 mutation knock-in heterozygotes and homozygotes displayed graded defective enamel with reduced thickness,inadequate mineralization and disorganized microstructure.This phenotype correlated with a gradual reduction in enamel matrix proteins and proteases across genotypes.Bulk RNA sequencing of ameloblasts suggested marked changes in adhesion-related genes and the Hippo-YAP pathway.We characterized cellular consequences of this variant using both LS8 and ALC cell lines,which appeared abnormalities including accelerated proliferation,undermined differentiation,weakened adhesion,and enhanced migration.In vivo and in vitro findings supported a model wherein the KDF1 mutation impaired intercellular and cell-matrix adhesion in ameloblasts.As a result,ameloblast differentiation was hampered through excessive nuclear yes-associated protein(YAP)accumulation and overactivation of downstream proliferative genes.Pharmacological blockade of YAP and TEA domain family member 1(TEAD1)interaction rescued the mutant phenotypes.Taken together,Kdf1 mutation compromised murine amelogenesis through adhesion defects and subsequent Hippo-YAP dysregulation. 展开更多
关键词 epithelial cellsthe intracellular regulator dental epithelium dysfunctionalthough enamel defect keratinocyte differentiation factor amelogenesis imperfecta KDF mutation
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Spatial variability of groundwater nitrate in the loess area of Tongchuan City,China:New insights from farmland leaching quantification 认领 引用
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作者 Wei Zhao Peiyue Li +5 位作者 Tiantian Wang Fangqiang Sun Fang Zhang Jia Yang Jing Ning Misbah Fida 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第5期512-521,共10页
High groundwater nitrate associated with agricultural activity is a global environmental problem.However,linking spatial variability of groundwater nitrate and agricultural activity quantification needs to be elucidat... High groundwater nitrate associated with agricultural activity is a global environmental problem.However,linking spatial variability of groundwater nitrate and agricultural activity quantification needs to be elucidated.This paper seeks to explain the spatial variability of groundwater nitrate in the loess area of Tongchuan City,China,identify the contributing factors using hydrogeochemical and statistical methods,and analyze the connection between farmland leaching and groundwater nitrate quantitatively.Results indicate that the nitrate of the Quaternary alluvial pore water(QAP)is significantly higher during the wet season(3.60 to 68.24 mg/L)compared to the dry season(3.53 to 37.20 mg/L).QAP nitrate is significantly higher than that in loess fissure-pore water(LFP),which ranges from 0.66 to 5.47 mg/L during the wet season and 0.82 to 5.01 mg/L during the dry season.The thin and loose vadose zone of QAP makes the aquifer particularly susceptible to anthropogenic influences.Following recharge from LFP,the hydrochemical parameters in QAP increased by 1.22 to 3.12 times(except Na+and pH),the change of average nitrate concentration in QAP(10.11 mg/L)was considerably higher than that in LFP(0.03 mg/L)due to farmland leaching.A significant correlation(R2=0.70 exists between groundwater nitrate and farmland leaching in river valleys and on slopes where farmland is prevalent.Fertilizer accumulation in river valleys enhances downward leaching,thereby further exacerbating groundwater nitrate.These findings highlight that river valleys with extensive farmland in the Loess Plateau should be prioritized for preventing and controlling groundwater nitrate pollution from agricultural activities. 展开更多
关键词 Spatial variability Hydrogeochemistry Statistical analysis Quantitative analysis Farmland leaching
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The combined exposure exacerbates the toxic effect of cadmium and uranium on rice seedlings 认领 引用
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作者 Jun Liu Meihan Cai +8 位作者 Jiajie Zhang Aili Mo Shiyu Hu Peishuang He Menglei Jiang Wei Zhao Cuiying Peng Tangjian Peng Fei Yang 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第4期444-455,共12页
Studies on the phytotoxicity of cadmium(Cd)and uranium(U)in rice mainly focus on single exposure.However,water,soil,and other environmental media are always co-contaminated by Cd and U.The effects of Cd(5 mg/L)and U(1... Studies on the phytotoxicity of cadmium(Cd)and uranium(U)in rice mainly focus on single exposure.However,water,soil,and other environmental media are always co-contaminated by Cd and U.The effects of Cd(5 mg/L)and U(10 mg/L)single and combined exposure for 7 days on rice seedlings were explored by hydroponic experiment.The synergism of U and Cd intensified the inhibitory effect of combined exposure on the rice seedling’s growth,accompanied by a remarkable reduction in chlorophyll content,alterations in antioxidant capacity,imbalances in mineral element metabolism,lipid peroxidation-induced destruction observed in rice seedlings,and significantly regulated expression of OsNramp5,OsHMA3,and OsHMA2,the adverse effects on the roots were more severe compared to those on the shoots.Combined exposure of U and Cd altered the distribution of U and Cd in the rice plant and subcellular.The accumulation of U and Cd in the rice seedlings’roots observably exceeded the shoot.Cd is mainly isolated in the vacuole and cell wall;U is primarily trapped in the cell wall.Cd promoted U accumulation in rice seedlings,while U inhibited Cd accumulation in rice seedlings.These findings can not only expand the understanding of the phytotoxicity of heavy metal combined exposure but also have important theoretical and practical significance for evaluating and remedying heavy metals contaminated-paddy soil and ensure for safe production of rice. 展开更多
关键词 Cadmium Uranium Combined exposure Phytotoxicity Rice seedling
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Regulating the local electronic structure of low-cost Fe/Mn-based layered oxide cathodes for rapid and stable sodium storage 认领 引用
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作者 Wei Zhao Shaohua Luo +3 位作者 Zhaozhan Shi Rui Huang Shengxun Yan Lixiong Qian 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第2期893-904,I0019,共12页
The P2-type Fe/Mn-based layered oxides,with cost advantages and high theoretical capacity,are considered one of the promising cathode materials for sodium-ion batteries(SIBs).However,the commercial development of thes... The P2-type Fe/Mn-based layered oxides,with cost advantages and high theoretical capacity,are considered one of the promising cathode materials for sodium-ion batteries(SIBs).However,the commercial development of these materials is impeded by two main factors:the MnO6 structure distortion induced by the Jahn-Teller(J-T)effect of Mn3+,and the unfavorable phase transitions that occur during the insertion and extraction of Na+.Here,we present a strategy to improve structural stability by incorporating cost-effective,robust Al-O bonds.This approach induces localized adjustments in the electronic structu re and a pinning effect,which limits the deformation of the transition metal(TM)layers,strengthens the electrostatic bonding within the TM layers,and expands the Na layer spacing.Consequently,the Na0.67Fe0.4Mn0.54Al0.06O2 cathode demonstrates a capacity of 168.8 mAh g-1 at 0.1 C,maintaining89.2%of its original capacity after 200 cycles at 1 C.Through in situ electrochemical impedance spectroscopy(EIS)with dynamic resistance transformation(DRT)analysis,ex situ X-ray absorption spectroscopy(XAS),and in situ X-ray diffraction(XRD),the study demonstrates a reduction in the J-T effect,enhanced kinetic performance,and the inhibition of detrimental phase transitions.This study offers new avenues to the development and design of future low-cost Fe/Mn-based cathodes. 展开更多
关键词 Local electronic Al-doping Low cost Layered oxide cathodes Sodium ion batteries
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Neural network control for mitigating actuator delay in ATR engines using predictive compensation and stability reward 认领 引用
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作者 Weidong CAI Wei ZHAO +3 位作者 Xiaorong XIANG Sanqun REN Xuesen YANG Qingjun ZHAO 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2026年第2期301-327,共27页
The flight envelope of Air Turbo Rocket(ATR)engines is broader compared to conventional aero-engines,and designing a full-envelope controller using traditional methods poses significant challenges due to a burdensome ... The flight envelope of Air Turbo Rocket(ATR)engines is broader compared to conventional aero-engines,and designing a full-envelope controller using traditional methods poses significant challenges due to a burdensome design process.To address this issue,this paper proposes a self-learning neural network controller design method based on Reinforcement Learning(RL).Additionally,a method for predictive compensation and stability rewards is proposed to reduce the system oscillation caused by actuator delay.This approach simplifies the actuator to a firstorder inertial element exhibiting pure delay.A simulation environment for the ATR engineactuator system is first established.Based on this environment,a self-learning neural network controller using a predictive compensator and the Proximal Policy Optimization(PPO)algorithm is then developed.Furthermore,the temporal difference signals from the controller output are integrated into the reward function to enhance system stability.The proposed method is validated through numerical simulations and semi-physical experiments.The numerical simulation results demonstrate that the proposed method increases the system's tolerance to delays from 20 ms to 400 ms.Under an actuator delay of 400 ms,the average steady-state error remains less than0.1%,the overshoot is limited to 1%,and the settling time does not exceed 3 s.Moreover,compared to the traditional method,the proposed method exhibits higher adaptability to model errors and variations in flight conditions.In the conducted semi-physical simulation experiments,the proposed method achieves stable control of a real electric pump. 展开更多
关键词 Actuator delay ATR engines Neural network control Reinforcement learning Semi-physical simulation
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Tailoring high-entropy sulfides as kinetic accelerators for all-solid-state lithium-sulfur batteries 认领 引用
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作者 Yating Huang Yajie Song +7 位作者 Wenze Huang Wei Zhao Qingsong Liu Jiajun Wang Jinpeng Song Bo Lu Xiang Xie Lujun Huang 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第7期352-360,I0010,共9页
All-solid-state lithium-sulfur batteries(ASSLSBs)hold promise as a next-generation energy storage technology,yet their practical deployment is hindered by sluggish sulfur redox kinetics and restricted triplephase inte... All-solid-state lithium-sulfur batteries(ASSLSBs)hold promise as a next-generation energy storage technology,yet their practical deployment is hindered by sluggish sulfur redox kinetics and restricted triplephase interfaces.Here,we designed a high-entropy sulfide(HES)material with mixed ionic-electronic conductivity as a multifunctional mediator to engineer robust ion/electron transport pathways and abundant catalytic sites within the cathode.This unique structural configuration significantly enhances charge transport and optimizes interfacial kinetics,dramatically reducing polarization.Critically,HESincorporated ASSLSBs exhibit superior performance at room temperature,achieving 84.0%capacity retention over 160 cycles at 1 C,a high capacity of 683.7 mAh g-1at 5.4 mA cm-2,and an exceptional areal capacity of 5.8 m Ah cm-2with a sulfur loading of 6 mg cm-2.This work demonstrates that highentropy-driven design principles can fundamentally address ion and electron transport challenges in sulfur cathodes,offering a viable strategy toward advanced ASSLSBs. 展开更多
关键词 High-entropy sulfides Ion-electron mixed conductivity Sulfur redox reaction kinetics Composite cathode All-solid-state lithium-sulfur batteries
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Synergistic localized interface engineering alleviating PGM-based catalyst from sulfonate poisoning in fuel cells via balanced adsorption modulation 认领 引用
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作者 Zihou Zhang Yuxiang Wang +5 位作者 Ping Fang Wei Zhao Yucheng Hou Fangce Li Maorong Chai Yujing Li 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第5期813-821,I0019,共9页
The performance of proton-exchange-membrane fuel cell(PEMFC)is known to be highly restrained by the nano-micro-scale ionomer-catalyst interface structure.The commonly used ionomers in the catalyst layer are functional... The performance of proton-exchange-membrane fuel cell(PEMFC)is known to be highly restrained by the nano-micro-scale ionomer-catalyst interface structure.The commonly used ionomers in the catalyst layer are functionalized by forming a nanoscale network with platinum-group-metal(PGM)based catalyst.The imbalanced binding strengths of sulfonate groups to the PGM surface compared to the carbon support surface lead to the favorable occupation of active sites for oxygen reduction reaction(ORR)and the declining performances in membrane electrode assembly(MEA).In this work,by employing a dual strategy on PGM and carbon support,a catalyst/support design is proposed to significantly reduce the variance in adsorption energies of sulfonate to the PGM and carbon surface.The balanced adsorption of sulfonate groups enables a more uniform distribution of ionomer on the catalyst surface with enhanced catalytic activity.The PtCo/CNH-N catalyst not only achieves a power density far exceeding that of its counterpart in MEA but also exhibits high stability against ionomer poisoning throughout potential cycling.Combining experimental evidence and theoretical calculation,this work corroborates the essential role of balanced binding strengths of sulfonate groups to PGM and carbon surface,and provides insight into the ionomer poisoning issue towards the design of a highly stable catalyst for PEMFC. 展开更多
关键词 Fuel cell N-functional group Oxygen reduction PGM catalyst Ionomer poisoning
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A novel effector of Aphelenchoides besseyi,AbPFN3,interacts with multiple host proteins to facilitate parasitic nematode and sustain infection in rice 认领 引用
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作者 Xin Huang Yuankai Chi +3 位作者 Wei Zhao Wenkun Huang Deliang Peng Rende Qi 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第4期1566-1574,共9页
The rice white tip nematode(RWTN)Aphelenchoides besseyi secretes effectors that manipulate host plant cells to facilitate successful parasitism and sustain infection.Although the number of identified RWTN effectors re... The rice white tip nematode(RWTN)Aphelenchoides besseyi secretes effectors that manipulate host plant cells to facilitate successful parasitism and sustain infection.Although the number of identified RWTN effectors remains limited,their mechanisms of interaction with host plants are largely unknown.Profilins(PFNs)function as molecular hubs that regulate complex interaction networks.To advance understanding of PFN3 in plant-parasitic nematodes,we identified an effector from A.besseyi,designated Ab PFN3.AbPFN3 is transcriptionally upregulated during the juvenile stage of the nematode,and in situ hybridization localized its expression to the esophageal glands.Three rice(Oryza sativa)proteins,ADP/ATP carrier protein 1(OsAAC1),B-cell receptor-associated protein 31(OsBAP31)and Small Auxin Up RNA 50(Os SAUR50),were identified as interactors of Ab PFN3,with interactions occurring in distinct cellular compartments,including the endoplasmic reticulum,cytoplasm,and plasma membrane.Transgenic analyses revealed that AbPFN3 expression significantly increased plant height and upregulated AAC1 and BAP31,while downregulating RGA2 and SAUR50.This study characterizes AbPFN3 as a novel effector secreted by A.besseyi that interacts with multiple host proteins,highlighting its potential role in modulating host defense responses and cell development processes. 展开更多
关键词 Aphelenchoides besseyi profilin 3 protein-protein interactions effector
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Atomically dispersed Fe-N4 sites on g-C3N4 enable highly selective CO2-to-CO electrocatalysis 认领 引用
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作者 Yongliang Ban Meng Zhang +4 位作者 Jianya He Chunfeng Shao Zhongliao Wang Wei Zhao Kai Dai 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第4期296-300,共5页
The development of efficient and cost-effective non-precious-metal single-atom catalysts(SACs)is crucial for advancing the practical application of electrocatalytic CO2 reduction(CO2RR).However,identifying highl... The development of efficient and cost-effective non-precious-metal single-atom catalysts(SACs)is crucial for advancing the practical application of electrocatalytic CO2 reduction(CO2RR).However,identifying highly active metal atoms and designing catalysts with uniform active center structures remain significant challenges.To address this,we developed a generic pyrolysis method to synthesize a series of transition metal-based SACs with atomically dispersed metal anchored on carbon nitride support(M-C3N4,M=Fe,Ni,Cu).Benefiting from the unique electronic structure of the Fe-N4 sites supported on C3N4,the Fe-C3N4 catalyst demonstrated exceptional performance,achieving a CO Faradaic efficiency of 99.6%and maintaining excellent stability.Theoretical calculations indicate that the Fe site exhibits a relatively stronger interaction with the*COOH intermediate,thereby helping to lower the energy barrier of the CO2 protonation process.This study provides valuable theoretical insights and practical synthesis strategies for designing high-performance non-precious-metal SACs for CO2RR. 展开更多
关键词 Electrocatalytic CO2reduction Single atom catalyst C3N4 Electron transfer Fe-N4sites
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Continuous-variable quantum secure direct communication with one-time pad 认领 引用
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作者 Yi-Yu Mao Chang-Hua Hu +2 位作者 Wen-Ti Huang Wei Zhao Lei Chen 《Chinese Physics B》 SCIE EI CAS CSCD 2026年第4期121-129,共9页
Quantum secure direct communication(QSDC)enables the direct transmission of secret messages over a quantum channel without prior key sharing.QSDC implemented in the continuous-variable(CV)regime allows high-capacity i... Quantum secure direct communication(QSDC)enables the direct transmission of secret messages over a quantum channel without prior key sharing.QSDC implemented in the continuous-variable(CV)regime allows high-capacity information transmission using simple optical communication technologies.In this work,we propose a novel CV-QSDC protocol with a quantum one-time pad,which achieves secure message transmission based on coherent states and unitary operations,and the receiver can directly obtain the secret messages after measuring the coherent states.The security of this protocol is jointly guaranteed by one-time pad encryption and a CV quantum key distribution(QKD)protocol.Performance analysis shows that the proposed scheme can achieve a quantum bit error rate(QBER)lower than 1% by adjusting the modulation variance and unitary operation parameters.With the optimal modulation variance,the secure transmission distance of the proposed protocol can exceed 150 km. 展开更多
关键词 quantum secure direct communication quantum-one-time pad continuous-variable
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Telomere-to-telomere,gap-free assembly of the Rosa rugosa reference genome 认领 引用 被引量：2
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作者 Dan Liu Kun Liu +8 位作者 Boqiang Tong Haili Guo Kai Qu Ting Xu Rengang Zhang Wei Zhao Xiaoman Xie Longxin Wang Kaihua Jia 《Horticultural Plant Journal》 SCIE CAS CSCD 2026年第6期1450-1464,共15页
Rosa,a genus esteemed worldwide for its ornamental plants,has encountered barriers in functional genomic studies and further genetic enhancement due to incomplete sequences and floating regions in previously sequenced... Rosa,a genus esteemed worldwide for its ornamental plants,has encountered barriers in functional genomic studies and further genetic enhancement due to incomplete sequences and floating regions in previously sequenced genomes.Our groundbreaking study introduced a meticulously assembled,continuous,and fully bridged reference genome for Rosa rugosa,constructed through a sophisticated combination of PacBio High-Fidelity,ONT ultra-long reads,and Hi-C data.This robust assembly spanned 444.55 Mb and encompassed 34109 protein-coding genes.We have uniquely assembled each chromosome into single,gap-free structures,successfully identifying all 14 telomeres and seven centromeres,a feat not achieved previously.The centromeric regions were distinguished by tandem repeats,primarily composed of centromere-specific 159-bp monomers,and a significant enrichment of ATHILA/Gypsy long terminal repeat retrotransposons in proximal regions.Our research highlighted recent tandem duplications as instrumental in bolstering R.rugosa's stress tolerance,environmental adaptability,and enhanced anthocyanin synthesis.Furthermore,our study ventured into uncharted territory by predicting transcription factors potentially regulating anthocyanin biosynthesis through the employment of gene co-expression networks,providing new avenues for research.This comprehensive reference genome not only serves as a cornerstone for in-depth exploration of genomic architecture and functionalities in R.rugosa but also acts as a catalyst for innovative breeding strategies and genetic refinement within the genus. 展开更多
关键词 Rosa Telomere-to-telomere genome assembly Anthocyanin biosynthesis
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Can chess-style strategic planning revolutionize high-speed engagement? 认领 引用
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作者 Can LIU Wei ZHAO +3 位作者 Tao YANG Tian YAN Wei HUANG Shuangxi LIU 《Journal of Zhejiang University-SCIENCE A》 SCIE EI CAS CSCD 2026年第5期549-554,I0055,共6页
1 Introduction Drawing inspiration from the triumph of artificial intelligence in complex board games,we propose a novel game-theoretic framework for optimizing decision-making in high-speed vehicle(HSV)pursuit‒evasio... 1 Introduction Drawing inspiration from the triumph of artificial intelligence in complex board games,we propose a novel game-theoretic framework for optimizing decision-making in high-speed vehicle(HSV)pursuit‒evasion game scenarios.The interaction between HSVs and defensive systems is reframed as a high-stakes game characterized by extreme dynamics,compressed decision windows,and partial observability;this presents computational challenges that mirror the strategic depth of board games like Go. 展开更多
关键词 high speed vehicle pursuit evasion game theoretic framework chess style strategic planning decision making computational challenges board gameswe defensive systems board games
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Tuning the additive participation in cathode-electrolyte-interphase construction via competitive adsorption for high-voltage LiCoO2 认领 引用
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作者 Ziwei Liu Lingfeng Shi +9 位作者 Yuangui Liu Chi Ma Guangxiang Zhang Shuai Li Wei Zhao Chunyu Du Hua Huo Geping Yin Rui Guo Yulin Ma 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第6期386-396,I0010,共11页
Charging LiCoO2(LCO)to a higher voltage could provide higher capacity and specific energy,while the severe interfacial instability would undermine the cycling life and safety of the battery.The rational and efficie... Charging LiCoO2(LCO)to a higher voltage could provide higher capacity and specific energy,while the severe interfacial instability would undermine the cycling life and safety of the battery.The rational and efficient construction of the cathode-electrolyte-interphase(CEI)is sought to tackle this issue.In general,the solvent structure tuning and electrolyte additive utilization work well on CEI formation,and the combined application of both always produces synergistic enhancements.However,the specific mechanism of the cumulative effect is still obscure,which needs further investigation and is believed to render electrolyte engineering more effective.Here,we propose that the competitive adsorption on the cathode is the key,which has been verified by comparing the effectiveness in assisting CEI film formation of the additives in different solvation environments.The free-solvent-anchoring achieved by 1,1,2,2-Tetrafluoroethyl-2,2,3,3-tetrafluoropropylether(TTE)diluent indeed promotes the Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate(MDFA)additive working on CEI formation.Along with the advanced inorganic-rich(LiF and Li-S species)CEI and the stable interphase&interface of LCO,it exhibits a reversible capacity of 87 mAh g-1at 10C and capacity retention of 82.29%after 100 cycles at 1C,which is much better than 49.44%of the case containing only the MDFA additive.This work emphasizes the importance of the solvation surrounding for the effective adsorption of additives on the LCO,and further sheds light on regulating the CEI chemistries for high-voltage cathodes. 展开更多
关键词 Li-ion battery Cathode electrolyte interphase Solvation structure Electrolyte additive Free-solvent-anchoring Competitive adsorption
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Development and characterization of neutralizing monoclonal antibodies against clinically relevant human adenovirus subgroup B serotypes 认领 引用
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作者 Yuelin Wang Wei Dou +11 位作者 Yingying Chen Ke Liu Mengjun Li Tyuji Hoshino Yushan Jiang Vladislav Victorovich Khrustalev Alexey V.Churov Alexander N.Orekhov Wei Zhao Ling Li Yang Yang Chenguang Shen 《Virologica Sinica》 SCIE CAS CSCD 2026年第2期404-412,共9页
Human adenoviruses(HAdVs),particularly subgroup B serotypes HAdV-3 and HAdV-55,are associated with severe respiratory disease and currently lack targeted therapies.While neutralizing monoclonal antibodies(nMAbs)offer ... Human adenoviruses(HAdVs),particularly subgroup B serotypes HAdV-3 and HAdV-55,are associated with severe respiratory disease and currently lack targeted therapies.While neutralizing monoclonal antibodies(nMAbs)offer promising therapeutic potential,the specific nMAbs targeting these serotypes remain poorly characterized.Therefore,this study aimed to generate and evaluate the efficacy of serotype-specific nMAbs against HAdV-3 and HAdV-55.Mice were immunized with HAdV-3 virions,HAdV-55 virions,or recombinant fiber knob proteins(HAdV-55/-7)for the generation of serotype-specific nMAbs,and their efficacy was systematically evaluated using in vitro assays and an in vivo tree shrew model.Through comprehensive screening,eleven MAbs were identified with specificity against HAdV-3(six clones)or HAdV-55/-7 fiber knob(five clones).Four nMAbs exhibited potent neutralizing activity:13F12(half-maximal inhibitory concentration,IC50:3.8μg/mL),8D2(IC50:15.1μg/mL),3A3(IC50:14.9μg/mL)against HAdV-3 virions,and 8F2 with neutralizing efficacy against HAdV-55 virions(IC50:30.4μg/mL).Western blot analysis revealed that MAbs 13F12 and 8F2 targeted the fiber protein,whereas 8D2 and 3A3 bound to the hexon protein.Furthermore,in vivo evaluations demonstrated that 13F12 significantly reduced viral loads in nasal turbinates and attenuated lung pathology in HAdV-3-infected tree shrews.Mechanistically,all tested anti-HAdV-3 nMAbs inhibited infection by blocking viral attachment(P<0.01 vs.controls).In conclusion,this study underscores the therapeutic potential of targeting viral entry and highlights 13F12 as a promising candidate for HAdV prophylaxis. 展开更多
关键词 Human adenovirus(HAdV) Neutralizing antibody Monoclonal antibody Antiviral therapy Respiratory infection B subgroup serotypes
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Mechanical and cushioning behaviors of knitted stainless steel mesh damper under cyclic and impact loading 认领 引用
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作者 Lijun Mao Wei Zhao +2 位作者 Zhiqian Li Zhaojun Pang Zhonghua Du 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2026年第5期550-573,共24页
To effectively reduce the recoil force generated by pyrotechnic launching devices during operation,this study applies a knitted stainless steel metal wire mesh damper(MWMD)to pyrotechnic launching systems and analyzes... To effectively reduce the recoil force generated by pyrotechnic launching devices during operation,this study applies a knitted stainless steel metal wire mesh damper(MWMD)to pyrotechnic launching systems and analyzes its mechanical behavior and buffering performance.Through quasi-static cyclic compression tests and numerical simulations,the effects of wire diameter(d)and relative density(ρ)of MWMD on its mechanical and rebound characteristics were investigated,along with its impact on recoil force in shock tests.The results demonstrate that MWMDs with smaller wire diameters(d)and lower relative densities(ρ)exhibit more cyclic loading cycles and superior rebound performance.Simulation data reveal that MWMDs with smaller wire diameters and higher relative densities display stronger resistance to repeated impacts under multiple cyclic shocks,demonstrating excellent energy absorption capability with an efficiency of up to 37.59%.According to impact test results,the MWMD reduces the peak recoil force from 42757.38 to 25701.47 N,achieving an energy absorption efficiency of 39.89%.The discrepancy between experimental and simulated results is minimal,with only a 5.75%discrepancy,the finite element model is validated,confirming the MWMD's effectiveness in mitigating recoil forces as a buffer in pyrotechnic launching devices. 展开更多
关键词 Metal wire mesh damper(MWMD) Mechanical behavior Numerical simulation Impact test
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Commercial Sugar Alcohol Boosts Nucleation and Crystallization Ability of Poly(ethylene succinate)via Combination of Intermolecular Interactions and Epitaxial Templating 认领 引用
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作者 Hao-Ting Yin Dong-Yuan Ye +3 位作者 Wei Zhao Xue-Wei Wei Xiao-Yu Meng Hai-Mu Ye 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2026年第3期781-791,I0014,共11页
Poly(ethylene succinate)(PES),a promising biodegradable polyester with cost advantages,suffers from inherently slow crystallization kinetics,which severely limits its processability and practical applications.To addre... Poly(ethylene succinate)(PES),a promising biodegradable polyester with cost advantages,suffers from inherently slow crystallization kinetics,which severely limits its processability and practical applications.To address this challenge,this study explored the use of commercially available,low-cost,and food-safe sugar alcohols,including Xylitol(Xy),D-sorbitol(DS),and D-mannitol(DM),as effective nucleating agents for PES.Remarkably,all three polyols significantly enhanced the nucleation and crystallization ability of PES,with DM exhibiting the most pronounced effect.DM increased the crystallization temperature by up to 23.9°C and accelerated the overall crystallization rate by more than 13-fold at only 0.5 wt%loading level.Through a combination of differential scanning calorimetry(DSC),polarized optical microscopy(POM),and wide-angle X-ray diffraction(WAXD)analyses,we revealed that DM promotes PES crystallization via a dual mechanism:epitaxial templating facilitated by excellent lattice matching,and enhanced chain adjustment through intermolecular hydrogen-bonding interactions.In contrast,Xy and DS primarily function through hydrogen-bonding interactions.This work not only identifies DM as a highly efficient,economical,and industrially viable nucleating agent for PES,but also provides fundamental insights into the role of the molecular structure and crystallization ability of nucleating agents in regulating polymer crystallization. 展开更多
关键词 Poly(ethylene succinate) Polyol Crystallization Nucleation
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Micro-sized Silicon Carbonitride Prepared by Radical Polymerization as a High-performance Anode Material for Lithium-ion Batteries 认领 引用
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作者 Xin Xia Zhen-Peng Zhang +5 位作者 De-Shuo Wang Yi-Han Li Jing-Jiang Sun Jian-Jiang He Qing-Fu Wang Wei Zhao 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2026年第8期2659-2669,I0016,共11页
To address the critical issue of volume expansion in silicon-based anode materials and enhance battery performance,a novel method for synthesizing microsized silicon carbonitride(SiCNO)ceramic particles was presented ... To address the critical issue of volume expansion in silicon-based anode materials and enhance battery performance,a novel method for synthesizing microsized silicon carbonitride(SiCNO)ceramic particles was presented as a high-performance anode material for lithium-ion batteries.SiCNO ceramic microspheres were prepared via high-temperature pyrolysis of organopolysilazane microspheres(OPSZ MPs),which were synthesized via free radical polymerization of silazane oligomers initiated by azobisisobutyronitrile(AIBN).The SiCNO microspheres,serve as the active materials in lithium-ion batteries anode,demonstrated excellent electrochemical performance with an initial discharge-specific capacity of 1663.3 mAh·g-1 and 622.9 mAh·g-1 after 400 cycles at 1 A·g-1.These microspheres exhibited superior structural stability during the lithiation and delithiation processes,with a volume expansion of 25.46%during cycling.The enhanced performance can be attributed to their regular spherical structures and larger specific surface area,which improve the ion/electron transport and stress distribution.This study highlights the potential of synthesizing and regulating the morphology of SiCNO particles to improve the performance of anode materials for lithium-ion batteries,providing a balance between high electrochemical activity and structural stability. 展开更多
关键词 Lithium-ion batteries Silicon/Carbon composite anode Micro-sized particles Polysilazane
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Sustained release of branched-chain amino acids from slow-digesting whey enhances endurance running performance and improves skeletal muscle protein synthesis in mice 认领 引用
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作者 Juncai Leng Tingyi Zhou +5 位作者 Yiming Jiang Beibei Wang Shuoming Liu Shiqi Zhang Li Li Wei Zhao 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第1期191-201,共11页
Post-exercise whey protein isolate(WPI)supplement is beneficial for skeletal muscle recovery due to the stimulation of branched chain amino acids(BCAAs).This implies us that intake slow digestion rate of protein to su... Post-exercise whey protein isolate(WPI)supplement is beneficial for skeletal muscle recovery due to the stimulation of branched chain amino acids(BCAAs).This implies us that intake slow digestion rate of protein to sustain BCAAs releasing rate may facilitate muscle protein synthesis.To examine this hypothesis,we conducted a series of protein supplements including modified slow-digesting whey(SDW),whey,hydrolyzed whey and casein,orally to mice undergoing endurance running.Our results showed that the SDW gavage constant supplied BCAAs in the serum of mice within 6 h and significantly enhanced(P<0.01)endurance exercise capacity,compared to other groups.In addition,the SDW supplementation increased the crosssectional area of mice gastrocnemius fibers,as well as their muscle and liver glycogen content.It also increased the testosterone/cortisol ratio in serum and interleukin-6(IL-6)levels in muscle,while it decreased the tumor necrosis factor-alpha(TNF-α)levels and oxidative stress in muscle.Moreover,it may activate mechanistic target of rapamycin signaling by upregulating mRNA(bcat-1 and pgc-1α)expression.Thus,our findings illustrate that prolonged BCAAs supply duration promotes mice endurance running capacity and skeletal muscle growth,contributing to the advancement of sports nutrition practices. 展开更多
关键词 Whey protein isolate(WPI) Branched chain amino acids(BCAAs) Endurance running Muscle protein synthesis
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Laparoscopic microwave ablation for hepatic hemangiomas with different locations:A comparative study 认领 引用
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作者 Chang-Le Wu Xi-Chi Chen +5 位作者 Wei Zhao Bin Hu Hong-Bo Huan Yu-Liang Tu Zi-Man Zhu Kai Jiang 《World Journal of Hepatology》 2026年第5期157-169,共13页
BACKGROUND Hepatic hemangioma(HH)is the most common benign liver tumor.However,the relative impact of lesion location and tumor size on postoperative outcomes following trans-arterial embolization(TAE)combined with la... BACKGROUND Hepatic hemangioma(HH)is the most common benign liver tumor.However,the relative impact of lesion location and tumor size on postoperative outcomes following trans-arterial embolization(TAE)combined with laparoscopic microwave ablation(LMWA)remains incompletely defined.In addition,heat-sinkrelated effects during ablation may contribute to perioperative complications,particularly in large or deeply located lesions.AIM To evaluate the association of lesion location and tumor size with short-term postoperative outcomes following TAE+LMWA under a standardized procedural protocol.METHODS This retrospective study included 152 patients with large or giant HH(GHH)who underwent TAE+LMWA.Lesions were categorized by location as subcapsular or parenchymal,and by size as large or GHHs.Perioperative parameters,postoperative complications,inflammatory markers,and hepatic and renal function indices were compared between groups.All patients were treated using a standardized ablation protocol incorporating a gas-blood outflow channel.RESULTS Lesion location was not significantly associated with most postoperative laboratory indices,although postoperative fever occurred more frequently in liver parenchymal than in liver subcapsular lesions.Tumor size demonstrated a more pronounced association with postoperative outcomes.Compared with large HH,GHH were associated with longer ablation times,greater intraoperative blood loss,delayed gastrointestinal recovery,and higher incidences of postoperative fever and hypoproteinemia.CONCLUSION Tumor size appears to be an important factor influencing short-term postoperative recovery following TAE+LMWA,whereas lesion location shows a limited and selective association.Under a standardized protocol incorporating a gas-blood decompression channel,a low incidence of major heat-sink-related complications was observed.However,given the retrospective design and absence of a control group,the potential role of this technical modification should be regarded as exploratory and requires prospective validation. 展开更多
关键词 Hepatic hemangioma Microwave ablation Lesion location Heat-sink effect Trans-arterial embolization Postoperative outcomes
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