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Understanding Agentic AI:Algorithms and Infrastructure 认领 引用 被引量：1
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作者 Wanlun Ma Yongjian Guo +5 位作者 Qing-Long Han Wei Zhou Xiaogang Zhu Junwu Xiong Sheng Wen Yang Xiang 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2026年第4期776-795,共20页
The rapid evolution of large language models(LLMs)towards autonomous Agentic artificial intelligence(AI)necessitates a systemic overhaul across algorithms,infrastructure,and architectures.This paper presents a unified... The rapid evolution of large language models(LLMs)towards autonomous Agentic artificial intelligence(AI)necessitates a systemic overhaul across algorithms,infrastructure,and architectures.This paper presents a unified view of the“Agentic AI Infrastructure,”connecting research threads often studied in isolation.First,post-training algorithms are reviewed,contrasting traditional reinforcement learning(RL)with emerging reasoning-centric methods and test-time scaling strategies.Next,the transition of RL training frameworks is analyzed from monolithic,colocated designs to disaggregated,asynchronous architectures tailored for the extreme variance of agentic rollouts.Furthermore,progress in agent construction is synthesized,covering reflection,planning,tool use,and multi-agent collaboration.By integrating these layers,the paper elucidates how agentic AI systems impose unique demands on underlying training systems.Finally,open challenges are outlined by covering capability scaling,efficiency,safety,privacy,and governance for reliable realworld agentic AI deployment. 展开更多
关键词 Agentic artificial intelligence (AI) AI Infrastructure post-training reinforcement learning (RL)
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Water Swelling-induced Stiffness Enhancement of Polymer Hydrogels 认领 引用 被引量：1
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作者 Yi Yu Wei Zhou +1 位作者 Tao Chen Wei Lu 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2026年第6期1749-1759,I0012,共11页
Polymer hydrogels with variable stiffness demonstrate immense practical application value,particularly when utilizing water as a trigger medium,which significantly expands their prospects in soft robotics,bioelectroni... Polymer hydrogels with variable stiffness demonstrate immense practical application value,particularly when utilizing water as a trigger medium,which significantly expands their prospects in soft robotics,bioelectronics,and artificial muscles.However,existing water-induced stiffening hydrogel rely on ionic liquids and inorganic salts,posing leakage risks during prolonged use.Here,we proposed a strategy for mechanically strengthening hydrogel through water-induced phase separation.By designing a polymer matrix featuring hydrophilic oligomeric ethylene glycol methacrylate(OEGMA)and hydrophobic methyl methacrylate(MMA)moieties,this poly[methyl methacrylate-co-poly(ethylene glycol)methacrylate][P(MMAx-co-OEGMAy)]hydrogel exhibited reversible stiffness switching across four orders of magnitude(from 1.88×10-2MPa to201.63 MPa)upon water stimulation.This abrupt stiffness enhancement stemmed from strong hydrogen bonding between water molecules and hydrophilic OEGMA segments,facilitating spontaneous aggregation and phase separation of hydrophobic MMA segments.The resulting hydrophobic MMA domains formed dynamic physical crosslinking points,thereby enhancing the hydrogel's stiffness.Furthermore,the hydrogel exhibited a time-dependent,multi-stage stiffness enhancement during water swelling.As proof of concept,it was employed as a shape-memory component to explore its application in the controllable programming of multi-stage complex shapes,offering novel design insights for developing environmentally friendly,high-mechanical-performance smart hydrogel materials. 展开更多
关键词 Polymer hydrogel Water-induced phase separation Stiffness enhancement Hydrogen bonding Shape memory
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Phenotype–Target Coupled Drug Screening:A High-Efficiency Framework for Innovative Drug Discovery from CHMs 认领 引用 被引量：2
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作者 Wei Zhou Yue Gao 《Engineering》 SCIE EI CSCD 2026年第2期10-13,共4页
Chinese herbal medicines(CHMs)serve as the cornerstone of traditional Chinese medicine(TCM)practices and are vital sources of inspiration for novel drug discovery.Many landmark drugs,including artemisinin,ephedrine,bi... Chinese herbal medicines(CHMs)serve as the cornerstone of traditional Chinese medicine(TCM)practices and are vital sources of inspiration for novel drug discovery.Many landmark drugs,including artemisinin,ephedrine,bicyclol,berberine,and dl-3-nbutylphthalide,originated from CHMs.Nevertheless,only 23.5%of the new drugs approved by the US Food and Drug Administration(FDA)over the past four decades have stemmed from botanical drugs,natural products,or their derivatives[1]. 展开更多
关键词 natural products phenotype target coupled drug screening botanical drugsnatural Chinese Herbal Medicines chinese herbal medicines chms serve novel drug discoverymany traditional chinese medicine tcm practices botanical drugs
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Activation of interleukin-33/suppression of tumorigenicity 2 signaling contributes to gallbladder carcinoma-induced chronic pain 认领 引用 被引量：1
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作者 Xian-Xiu Ge Xin-Ming Dong +3 位作者 Yang Yang Wen Zhang Wei Zhou Xue-Ting Deng 《World Journal of Gastrointestinal Oncology》 SCIE 2026年第3期211-223,共13页
BACKGROUND Patients with gallbladder carcinoma(GBC)often report abdominal pain,which is particularly severe,difficult to treat,and insufficiently relieved.Interleukin-33(IL-33)/suppression of tumorigenicity 2(ST2)sign... BACKGROUND Patients with gallbladder carcinoma(GBC)often report abdominal pain,which is particularly severe,difficult to treat,and insufficiently relieved.Interleukin-33(IL-33)/suppression of tumorigenicity 2(ST2)signaling plays a role in cancer and pain,but its role in GBC-induced chronic pain is still unknown.AIM To investigate the potential effects of IL-33/ST2 signaling on GBC-induced cancer pain.METHODS To establish a GBC-induced chronic pain model,the GBC cell line GBC-SD was implanted into the gallbladder of nude mice.Pain-related behavior was determined by evaluating withdrawal behavior in response to mechanical stimuation.Serum samples from patients were analyzed via enzyme-linked immunolsorbent assay.Spinal cord samples from the rodents were subjected to enzyme-linked immunosorbent assay,western blotting and quantitative real-time polymerase chain reaction.RESULTS Nude mice with GBC-induced chronic pain presented significant spontaneous visceral pain-related behavior and abdominal hypersensitivity to mechanical stimuli.We demonstrated a significant increase in IL-33 levels in patient serum and in the spinal cords of GBC-induced chronic pain model mice.IL-33/ST2 signaling activation in the spinal cord may promote GBC-induced chronic pain.Remarkable activation of astrocytes and microglia as well as increased levels of proinflammatory cytokines was observed in the spinal cords of the mice.A significant decrease in the activation of astrocytes and microglia and the levels proinflammatory cytokines was observed following the blockade of IL-33/ST2 signaling.CONCLUSION Blockade of spinal IL-33/ST2 signaling results in a significant reduction in GBC-induced pain-related behaviors.This study suggested that targeting IL-33/ST2 signaling may relieve chronic cancer pain due to GBC. 展开更多
关键词 Interleukin-33 Gallbladder carcinoma Chronic cancer-related pain Spinal cord Proinflammatory cytokines
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OpenClaw in the Wild:Security Analysis of Autonomous Agents 认领 引用
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作者 Wanlun Ma Qing-Long Han +5 位作者 Xiaogang Zhu Wei Zhou Junwu Xiong Zhihang Ren Sheng Wen Yang Xiang 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2026年第6期1257-1273,共17页
Autonomous self-hosted AI agent platforms are rapidly evolving from prompt-response assistants into persistent systems that can maintain long-lived state,invoke tools,ingest external content,and execute environment-ch... Autonomous self-hosted AI agent platforms are rapidly evolving from prompt-response assistants into persistent systems that can maintain long-lived state,invoke tools,ingest external content,and execute environment-changing actions.While this transition enables practical automation,it also introduces lifecycle security risks that cannot be fully explained by prompt-level analysis alone.In this paper,a security analysis of OpenClaw is presented,with OpenClaw serving as a representative autonomous agent operating environment and a concrete case study for broader security challenges in emerging agent ecosystems.A trust-boundary-first perspective is adopted to examine how attacks propagate across five boundary classes:ChannelAccess,Session-and-State,Tool-Execution,External-Content,and Extension Supply-Chain.The results presented in this paper show that threats such as indirect prompt injection,memory poisoning,unsafe tool invocation,data exfiltration,and malicious skill abuse are not isolated anomalies;rather,they are stage-specific manifestations of a common systems problem in which untrusted influence progressively crosses into higher-privilege contexts.Based on this analysis,the defense-in-depth implications for OpenClaw deployments are discussed,including boundary-aware isolation,capability-scoped tool mediation,memory integrity controls,extension governance,and evidence-oriented operational oversight.This study provides a practical framework for evaluating and hardening long-running,tool-capable,autonomous AI agents in realistic deployment settings. 展开更多
关键词 OpenClaw autonomous agents security analysis adversarial machine learning trustworthy AI
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Biochar amendment affects soil nitrogen transformation and nitrous oxide emission:A15N tracer study 认领 引用
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作者 Jie ZHANG Ping HE +5 位作者 Liang JIN Dan WEI Xinpeng XU Shicheng ZHAO Wei ZHOU Shaojun QIU 《Pedosphere》 SCIE CAS CSCD 2026年第2期595-602,共8页
Biochar amendment is considered a potential strategy to improve soil fertility and mitigate climate change,yet its specific effects on the fate of fertilizer-derived and native soil nitrogen remain unclear.To elucidat... Biochar amendment is considered a potential strategy to improve soil fertility and mitigate climate change,yet its specific effects on the fate of fertilizer-derived and native soil nitrogen remain unclear.To elucidate the effect of biochar amendment on soil nitrogen(N)transformation and nitrous oxide(N2O)emission,a 56-d soil incubation experiment was conducted using15N isotope tracing to monitor the fate of N.Three treatments were set up:ⅰ)no addition of N or biochar control(CK),ⅱ)addition of15N-labeled ammonium sulfate((NH4)2SO4)(NS),andⅲ)combined addition of15N-labeled(NH4)2SO4and biochar(NS+BC).The15N abundances in soil ammonium(NH4+),nitrate(NO3-),microbial biomass N(MBN),particulate organic N(PON),mineral-associated total N(MTN),and N2O were measured.Compared with NS,endogenous soil N-derived NH4+-N and N2O decreased significantly by 34.4%-67.6% and 18.3%-51.2%,respectively,and exogenous N-derived NH4+-N,MTN,and N2O decreased significantly by 49.6%-81.4%,15.0%-47.0%,and 42.3%-76.5%,respectively,in NS+BC during the first 14 d.Biochar amendment significantly increased endogenous and exogenous soil N retention in MBN by 16.7%-40.1% and over 200 times,respectively,during the first 21 d.The endogenous and exogenous soil N retention in PON increased by12.5%-27.0% and 18.2%-78.5%,respectively,over the whole incubation period.For MTN,the endogenous and exogenous soil N retention increased by 3.9%-6.1% and 24.9%-30.6%,respectively,from days 21 to 56.The contribution of endogenous N to the total N2O emission was>80% across treatments.These results show that biochar amendment can mitigate soil N2O emission and promote inorganic N translocation into MBN,PON,and MTN in soil. 展开更多
关键词 endogenous N exogenous N microbial biomass N mineral-associated total N 15N isotope tracing particulate organic N soil N pool
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Corrigendum to“Inosine:A broad-spectrum anti-inflammatory against SARS-CoV-2 infection-induced acute lung injury via suppressing TBK1 phosphorylation”[J.Pharm.Anal.13(2023)11–23] 认领 引用
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作者 Ningning Wang Entao Li +9 位作者 Huifang Deng Lanxin Yue Lei Zhou Rina Su Baokun He Chengcai Lai Gaofu Li Yuwei Gao Wei Zhou Yue Gao 《Journal of Pharmaceutical Analysis》 SCIE CAS CSCD 2026年第1期309-311,共3页
The authors regret the unintentional error in the use of the GAPDH band in the original Fig.5C.The corrected figure is provided as the new Fig.5C below.This change does not affect the conclusions of the paper.
关键词 corrected figure inosine anti inflammatory TBK phosphorylation SARS CoV GAPDH acute lung injury gapdh band
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Pulsed Dynamic Water Electrolysis:Mass Transfer Enhancement,Microenvironment Regulation,and Hydrogen Production Optimization 认领 引用
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作者 Xuewei Zhang Wei Zhou +7 位作者 Xiaoxiao Meng Yuming Huang Yang Yu Haiqian Zhao Lijie Wang Fei Sun Jihui Gao Guangbo Zhao 《Nano-Micro Letters》 SCIE EI CAS CSCD 2026年第3期807-859,共53页
Pulsed dynamic electrolysis(PDE),driven by renewable energy,has emerged as an innovative electrocatalytic conversion method,demonstrating significant potential in addressing global energy challenges and promoting sust... Pulsed dynamic electrolysis(PDE),driven by renewable energy,has emerged as an innovative electrocatalytic conversion method,demonstrating significant potential in addressing global energy challenges and promoting sustainable development.Despite significant progress in various electrochemical systems,the regulatory mechanisms of PDE in energy and mass transfer and the lifespan extension of electrolysis systems,particularly in water electrolysis(WE)for hydrogen production,remain insufficiently explored.Therefore,there is an urgent need for a deeper understanding of the unique contributions of PDE in mass transfer enhancement,microenvironment regulation,and hydrogen production optimization,aiming to achieve low-energy consumption,high catalytic activity,and long-term stability in the generation of target products.Here,this review critically examines the microenvironmental effects of PDE on energy and mass transfer,the electrode degradation mechanisms in the lifespan extension of electrolysis systems,and the key factors in enhancing WE for hydrogen production,providing a comprehensive summary of current research progress.The review focuses on the complex regulatory mechanisms of frequency,duty cycle,amplitude,and other factors in hydrogen evolution reaction(HER)performance within PDE strategies,revealing the interrelationships among them.Finally,the potential future directions and challenges for transitioning from laboratory studies to industrial applications are proposed. 展开更多
关键词 Pulsed dynamic electrolysis Water electrolysis Energy and mass transfer Microenvironment System stability
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Synergy of electron-trapping centers and solid adsorption toward 100%suppression of toxic byproduct N2O in photocatalytic NO reduction 认领 引用
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作者 Lijun Liao Yuhao Wang +6 位作者 Yanbo Li Yingchun Chen Ruting Yuan Bo Wang Tiancheng Zhuang Guangquan Zhao Wei Zhou 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第3期358-364,共7页
Photocatalysis shows promising application in efficient reduction of nitrogen oxides(NOx).However,the sluggish selectivity in nitric oxide removal with reductants,resulting in the formation of undesired N2O bypr... Photocatalysis shows promising application in efficient reduction of nitrogen oxides(NOx).However,the sluggish selectivity in nitric oxide removal with reductants,resulting in the formation of undesired N2O byproducts,presents a great challenge.In this work,complete prohibition of nitric oxide generation in photo-removal of NO with carbon particulate is successfully achieved through the rational regulation of electron-trapping centers on TiO2nanosheets(TNS)surface achieved by the surface reduction treatment with NaBH_4.The efficient suppression(100%)of N2O generation is ascribed to the more stable N2O adsorption on the active(001)crystalline plane of TNS and the electron-capturing ability around oxygen vacancies based on the density functional theory(DFT)and experimental investigations.The existence of O2and H2O effectively promote the photocatalytic activity of NO reduction but demonstrate no adverse effect on N2O suppression.The optimal photocatalytic NO reduction activity with the highest CO2formation rate of 5.54 mg g-1h-1without N2O formation is achieved over the optimized 0.135-TNS.These investigations guide the development of feasible photocatalytic treatment of air pollutants,emphasizing the significance of managing electron capture and gas adsorption for efficient byproduct control in pollutants removal. 展开更多
关键词 Photocatalysis N2O adsorption Electron enrichment Nitric oxide Reduction
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GS-9620 alleviates psoriasis-like inflammation by regulating autophagy in keratinocytes 认领 引用
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作者 Yansi Lyu Wei Zhou +6 位作者 Pei Zhang Chen Lin Xin Wen Zigang Zhao Guoqiang Zhang Qian Zhang Si Chen 《Animal Models and Experimental Medicine》 CAS CSCD 2026年第7期1364-1372,共9页
Background:Psoriasis is an immune-driven dermatosis marked by keratinocyte hyperproliferation.GS-9620,a TLR7 agonist,previously mitigated EV71-triggered inflammation in mice;here we probe its anti-psoriatic potential ... Background:Psoriasis is an immune-driven dermatosis marked by keratinocyte hyperproliferation.GS-9620,a TLR7 agonist,previously mitigated EV71-triggered inflammation in mice;here we probe its anti-psoriatic potential and mechanisms.Methods:IMQ-induced psoriasis-like mice were treated with GS-9620 or MTX;severity was tracked by PASI and histology.Skin/spleen cytokines(IL-1β,IL-6,IL-18,HMGB1,TNF-α)were quantified via ELISA;immune subsets were quantified by flow cytometry.Autophagy proteins(ATG5/12/16 L1)and NLRP3 were assessed by IHC/Western blot.In vitro,M5-stimulated primary keratinocytes were treated with GS-9620±autophagy modulators,followed by cytokine and protein analyses.Results:GS-9620 markedly reduced erythema,scaling and epidermal thickness,lowered skin and systemic cytokines,and decreased splenic CD3+/CD4+IL-17A+cells.It restored ATG5/12/16 L1 expression while suppressing NLRP3 both in lesions and in M5-stimulated keratinocytes,leading to diminished IL-1β,IL-6,IL-18,HMGB1 and TNF-αrelease.Conclusions:GS-9620 alleviates psoriasis by enhancing autophagy and dampening NLRP3-mediated inflammation,offering a promising therapeutic avenue. 展开更多
关键词 anti-psoriasis drugs autophagy GS-9620 NLRP3 PASI psoriasis
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Genomic sequencing as a key primary recommendation for neonatal hyperbilirubinemia:a population-based multicenter study 认领 引用
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作者 Dabin Huang Xia Gu +10 位作者 Weizhong Li Hongying Mi Haiquan Zeng Guiying Zhuang Sitao Li Congcong Shi Tao Wei Wei Zhou Xin Xiao Wenhao Zhou Hu Hao 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2026年第3期467-475,共9页
Genetic variations are risk factors for neonatal hyperbilirubinemia(NHB),a common cause of infant hospitalization in the first postnatal week,but their contribution and long-term impacts remain unclear.This population... Genetic variations are risk factors for neonatal hyperbilirubinemia(NHB),a common cause of infant hospitalization in the first postnatal week,but their contribution and long-term impacts remain unclear.This population-based multicenter study enrolls 1780 hospitalized NHB newborns and 38,158 genetically screened newborns across 20 hospitals(2019-2022).Excluding cases with clear clinical causes,977 NHB cases are categorized into genetic variation-positive and-negative groups.Results show significantly higher NHB-related gene variants(81.63%vs.65.62%)and positive variation rates(36.29%vs.9.4%)in NHB cases than in the general newborn population(all P<0.001).Among the 977 NHB cases,325(33.3%)have positive variants,with higher rates of severe hyperbilirubinemia(16.9%vs.9.7%,P=0.001),prolonged jaundice(36.3%vs.27.6%,P=0.005),and cholestasis/hypercholanaemia(23.7%vs.14.7%,P<0.001)in the positive group.Cumulative genetic variants in bilirubin metabolism pathways exhibit dosedependent associations with increased risks of complications.Long-term follow-up reveals that UGT1A1 variants prolong jaundice up to one month,while severe SLC10A1 variants cause persistent cholestasis/hypercholanaemia beyond nine months.This large-scale evidence highlights genetic factors as key NHB determinants,with implications for neonatal care protocols to integrate genetic testing and establish longterm surveillance for variant carriers. 展开更多
关键词 Neonatal hyperbilirubinemia Jaundice polygene metabolic disorder Genetic variations Prolonged jaundice Multicenter observational study
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Phloretin targeting the 3CLpro Cys144 exhibits broad-spectrum antiviral activity against swine enteric coronavirus 认领 引用
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作者 Jiawei Xiao Donghua Guo +17 位作者 Xiaoxu Xing Limin Jiang Shanshan Qi Jun Wang Wenfei Bai Shiping Yu Fanbo Shen Xingyang Guo Xinglin Wang Wei Zhou Hansong Li Feiyu Zhao Li Feng Jialin Zhang Yaru Xu Dan Yang Haixin Liu Dongbo Sun 《Virologica Sinica》 SCIE CAS CSCD 2026年第1期208-226,共19页
Swine enteric coronaviruses(SECoVs)cause severe watery diarrhea and high mortality in piglets,resulting in significant economic losses to the global pig industry.However,frequent mutations in SECoVs significantly comp... Swine enteric coronaviruses(SECoVs)cause severe watery diarrhea and high mortality in piglets,resulting in significant economic losses to the global pig industry.However,frequent mutations in SECoVs significantly compromise vaccine-induced immunity and limit cross-protection against emerging variants.Therefore,there is an urgent need to develop new broad-spectrum antiviral drugs to be the last line of defense to supplement vaccine immunity.In this study,we utilized molecular docking and molecular dynamics simulations to identify phloretin as a broad-spectrum SECoV inhibitor.Phloretin has demonstrated prophylactic and therapeutic efficacy in vitro and in vivo,improving the survival of SECoV-infected piglets.It was further found that phloretin exerts a broad-spectrum antiviral effect by acting on the conserved 3CLpro Cys144 site of three SECoVs.It is worth noting that derivative A12,designed on the basis of the structure-activity relationship(SAR)between phloretin and 3CLpro,showed a 15.7,2.6,and 8.4-fold increase in antiviral effect against porcine epidemic diarrhea virus(PEDV),transmissible gastroenteritis virus(TGEV),and porcine delta coronavirus(PDCoV),respectively.This study reveals a 3CLpro Cys144 targeting broad-spectrum strategy for use against SECoVs,providing a candidate drug to bridge the vaccine immunity gap. 展开更多
关键词 Phloretin Swine enteric coronaviruses 3C-like protease Broad-spectrum antiviral Structural modification
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Autonomous driving scenario generation based on neural radiance fields or 3D Gaussian splatting:State-of-the-art investigations,reviews,and perspectives 认领 引用
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作者 Wei Zhou Wenbo Chu +4 位作者 Yue Tian Tianyang Fei Yulong Ding Xiaolin Tang Keqiang Li 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2026年第2期226-240,共15页
Reconstruction of autonomous driving scenarios plays a pivotal role in vehicle testing.In recent years,approaches based on Neural Radiance Fields(NeRF) and 3D Gaussian Splatting(3D GS) have opened new avenues for enha... Reconstruction of autonomous driving scenarios plays a pivotal role in vehicle testing.In recent years,approaches based on Neural Radiance Fields(NeRF) and 3D Gaussian Splatting(3D GS) have opened new avenues for enhancing the performance of vehicle testing systems.This paper provides a systematic review of the latest research progress on NeRF and 3D GS in the context of autonomous driving scene reconstruction and explores their potential for future applications in the development of autonomous driving test systems.First,the paper briefly reviews the development trajectories of NeRF and 3D GS,presenting a concise timeline of representative works based on major databases such as Web of Science,IEEE Xplore,and arXiv,thereby offering essential background for the subsequent discussion.Next,the current state of research is comprehensively analyzed,with a particular focus on advancements in model architecture,scene editing,and the reconstruction of challenging autonomous driving scenarios.Finally,the paper outlines a research outlook on an integrated test system centered on NeRF or 3D GS,encompassing modules for large-scale dynamic scene reconstruction,autonomous scene editing,and perception-decision algorithms.This integrated framework aims to provide a valuable reference for building efficient and scalable testing platforms for autonomous driving. 展开更多
关键词 Autonomous driving Scenario generation Neural radiance fields 3D Gaussian splatting
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Exosomal EPHA2 transfers metastatic potential by stabilizing TGF-βRI and activating the TGF-β/SMAD3 signaling pathway in breast cancer 认领 引用
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作者 Liming Liu Yichu Zhang +11 位作者 Xiaoxue Li Yueni Mo Lanlan Song Yidi Jia Luoming Zhang Wei Zhou He Zhang Hui Guo Zhiyong Wang Yanfen Cui Fei Zhang Ruifang Niu 《Cancer Biology & Medicine》 SCIE CAS CSCD 2026年第8期1128-1155,I0004-I0009,共28页
Objective:Intratumoral heterogeneity refers to the presence of distinct subpopulations of cancer cells within a single tumor,which exhibits variations in phenotypic traits,such as proliferation rate,drug sensitivity,a... Objective:Intratumoral heterogeneity refers to the presence of distinct subpopulations of cancer cells within a single tumor,which exhibits variations in phenotypic traits,such as proliferation rate,drug sensitivity,and metastatic potential.Dynamic interactions among heterogeneous cell populations have a critical role in tumor progression.Increasing evidence underscores the importance of intercellular communication among heterogeneous cancer cell subpopulations in driving malignancy.However,the molecular mechanisms governing such cancer cell-to-cancer cell interactions are poorly understood.Methods:Exosomes were isolated from highly metastatic breast cancer cells(HM-BCCs)and low metastatic breast cancer cells(LM-BCCs).The role of exosome-mediated intercellular communication on metastatic behavior was assessed using wound healing and Transwell assays.Gene knockdown and overexpression strategies,small-molecule inhibitors,and xenograft mouse models were used to elucidate the role of exosomal EPHA2.Results:Exosomes derived from HM-BCCs considerably enhanced the migratory and invasive capabilities of LM-BCCs in vitro and increased the metastatic potential in vivo.Mechanistically,EPHA2 was identified as a key protein enriched in exosomes from HM-BCCs and was shown to be transferred to LM-BCCs by these vesicles.Exosomal EPHA2 promoted epithelial-to-mesenchymal transition in LM-BCCs when internalized by stabilizing TGF-βRI and activating the transforming growth factor-β/mothers against decapentaplegic homolog 3(TGF-β/SMAD3)signaling pathway,thereby facilitating the acquisition of a metastatic phenotype.Conclusions:The results underscore the pivotal function of exosomal EPHA2 in mediating the transfer of metastatic potential among heterogeneous breast cancer cell populations.Targeting the EPHA2-TGF-βRI signaling axis may provide a novel therapeutic approach for preventing or limiting breast cancer metastasis. 展开更多
关键词 Breast cancer intratumor heterogeneity exosomes EPHA2 TGF-βRI
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A self-leveling-like effect for dendrite-free lithium metal anodes via gradient-enhanced electric field hosts 认领 引用
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作者 Yi Yang Chang Yu +8 位作者 Qiang Zhang Shuo Liu Junting Dong Weizhe Liu Wei Zhou Jiani Chen Wenbin Li Shiqiang Liu Jieshan Qiu 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2026年第4期258-268,I0007,共11页
For Li metal battery,Li metal anodes severely suffer from dendritic growth due to heterogeneous electrodeposition,which inhibits their development and application.While extensive studies for Li dendrite suppression em... For Li metal battery,Li metal anodes severely suffer from dendritic growth due to heterogeneous electrodeposition,which inhibits their development and application.While extensive studies for Li dendrite suppression empirically utilize 3D hosts to homogenize the micro-scaled electric field within the host,the inherent correlation between host structure and electric field distribution and underlying principles remains elusive,and the corresponding design of hosts to enhance the electric effects remains challenging.Here,the host microstructure-electric field correlations are established via COMSOL simulations and demonstrate the enhanced redistribution of the electric field through structural redesign of hosts.Based on a structure model,an enhanced gradient electric field host(EGHx)with a supercontinuous gradient pore architecture is fabricated with the assistance of the porogen dissolution method,which achieves a self-leveling-like Li deposition through spatially programmed charge redistribution.Through further structural optimization,the EGH2(with 2 wt%porogen)exhibits an~98%Coulombic efficiency(CE)over 350 cycles(1 mA cm-2,1 mAh cm-2).Further multidimensional testing with argon protection reveals the role of the host in modulating solid-electrolyte interphase(SEI)composition.Accordingly,the EGH2 enables stable dendrite-free Li plating/stripping behaviors for 2100 h.The assembled full cell and pouch cell also display stable cycling performance with an LFP cathode. 展开更多
关键词 Enhanced gradient electric field Carbon host Li metal anodes Supercontinuous pore
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Superionic Conduction Through Lattice Engineering of Fluorites Stabilizing Periodic Oxygen Vacancy Network 认领 引用
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作者 Shahzad Rasool Muhammad Faisal Anwar +16 位作者 Sarfraz Nabeela Akbar Wei Zhou Shuo Wan Rizwan Raza Muhammad Afzal Li Sun Chenjie Lou Mingxue Tang Aristides D.Zdetsis Hind Himayyid Aljaddani Mohamed Elfleet Peter D.Lund Muhammad Imran Asghar Yifu Jing Qi Fan Bin Zhu 《Energy & Environmental Materials》 SCIE EI CAS CSCD 2026年第3期536-545,共10页
Superionic conductors with an exceptionally high ionic conductivity are placed central in the development of next-generation energy conversion and storage technologies,yet their designing approach and materials remain... Superionic conductors with an exceptionally high ionic conductivity are placed central in the development of next-generation energy conversion and storage technologies,yet their designing approach and materials remain a persistent challenge.Here,we report an alternative cation-ordered Ce-Al(1:1)fluorite oxide(ACO)that stabilizes a periodic oxygen vacancy(Ov)network to build the required architecture.The resulting lattice-engineered configuration creates a uniform and flattened potential energy landscape with significantly reduced activation energy,capable of a superionic conductivity of 0.216 S cm⁻¹ and a fuel cell power density of 1086 mW cm⁻² at 500℃.Unlike conventional random ion hopping in doped oxides,the vacancy-ordered framework supports coherent,phonon-assisted and wave-like ion motion enabling dielectric-enhanced superionic conduction.These findings introduce a new family of superionic conductors,where lattice-level ordering of both cations and Ovs offers a scalable design strategy for high-performance efficient electrochemical systems. 展开更多
关键词 dielectric-enhanced superionic conduction lattice-engineered configuration periodic oxygen vacancy superionic conductors vacancy-ordered framework
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Atmospheric Boundary Layer Eco-Environment Shanghuang Observatory:An Integrated Multiscale Research Platform in Southeastern China for Understanding Boundary Layer Processes,Atmospheric Chemistry Feedback,and Extreme Weather–Climate Linkages 认领 引用
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作者 Zifa WANG Xiaole PAN +27 位作者 Yele SUN Jinyuan XIN Hang SU Junji CAO Jie LI Ting YANG Hang LIU Weijie YAO Weiqi XU Xueshun CHEN Wei ZHOU Yongjing MA Xueling CHENG JING YE Bo HU Rubin JIANG Zhe WANG Baozhu GE Lin WU Xinwei LI Jinxi LI Zichen WU Lei KONG Mingming ZHU Jia JIA Xingyu LI Xuekun FANG Lanzhong LIU 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2026年第6期1291-1299,共9页
In the context of global warming,the increasing frequency of extreme weather events,meteorological disasters,and regional pollution events highlights the urgent need for targeted atmospheric observations in ecological... In the context of global warming,the increasing frequency of extreme weather events,meteorological disasters,and regional pollution events highlights the urgent need for targeted atmospheric observations in ecologically sensitive regions.The atmospheric boundary layer top remains a critical yet under-observed interface in climate and environmental research.To respond to this need,the Atmospheric Boundary Layer Eco-Environment Shanghuang Observatory(ABLES)was established in 2023 by the Institute of Atmospheric Physics,Chinese Academy of Sciences in Jinhua,southeastern China.As a high-altitude,state-of-the-art research platform,ABLES addresses the critical need for comprehensive atmospheric and environmental observations in East Asia.The observatory facilitates interdisciplinary research focusing on three core areas:(1)cross-sphere transport of pollutants between atmospheric layers and its environmental and climatic impacts;(2)physical and chemical interactions between clouds and aerosols under extreme weather conditions;and(3)multiscale feedback mechanisms between climate change and ecosystems.ABLES is also aimed at revealing long-term patterns in greenhouse gases,ozone depleting substances,and cloud properties,and to elaborate the formation mechanisms of severe weather events such as thunderstorms and freezing rain.The findings at ABLES will support advances in weather forecasting,air quality modeling,and adaptive strategies for climate resilience.As part of China's growing environmental monitoring network,ABLES has been collaborating with various research organizations,serving as a cooperative research platform for technological development and evidence-based environmental policymaking. 展开更多
关键词 multiscale research platform atmospheric environment extreme meteorology
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High-entropy strategies transforming solid oxide cells:Progress and perspectives 认领 引用
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作者 Ming Xiao Haosong Di +5 位作者 Zuoqing Liu Yuesheng Bai Ran Ran Wei Zhou Guangming Yang Zongping Shao 《Materials Reports(Energy)》 EI 2026年第1期1-19,共19页
Solid oxide cells(SOCs)have emerged as one of the key technologies for low-carbon energy transition due to their fuel flexibility and high system efficiency.However,their long-term deployment remains hindered by mater... Solid oxide cells(SOCs)have emerged as one of the key technologies for low-carbon energy transition due to their fuel flexibility and high system efficiency.However,their long-term deployment remains hindered by material degradation and interfacial instability under high-temperature and multi-atmospheric operating conditions.In particular,achieving a balance between catalytic activity and structural stability presents a major bottleneck in material design.High-entropy materials(HEMs),with their unique configurational entropy effect,multi-principal element synergy,and tunable local defect chemistry,offer a promising pathway to overcome these limitations.This perspective reviews recent advances in the application of HEMs in SOCs,including element selection and structure tuning,machine-learning-assisted design,in situ leaching and self-assembly engineering,and high-entropy coating strategies.Special attention is paid to how HEMs leverage their multi-elemental composition and defect regulation to enhance electrode performance,stabilize interfaces,and improve tolerance to poisoning species.We further highlight the potential of data-driven approaches for accelerating HEM screening and performance optimization,and discuss the integration of high-throughput experimentation with computational modeling to enable efficient exploration of the vast compositional space.Despite the remarkable progress,key challenges remain in achieving long-term stability and reliability across diverse operating scenarios.Future research should focus on precise control of non-equimolar compositions,development of cross-scale dynamic characterization techniques,and establishment of closed-loop frameworks that couple data-driven models with experimental feedback.These efforts will pave the way toward the rational design of high-performance,durable SOC systems. 展开更多
关键词 High-entropy materials Solid oxide cells Machine-learning-assisted design Defect engineering In situ assembly
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Commentary:Roles of metal-organic frameworks in sustainable agriculture——A critical overview 认领 引用
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作者 Wei Zhou 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第5期2167-2168,共2页
The recent review article "Green agriculture enabled by versatile metal-organic frameworks:A review" by Wan et al.(Journal of Integrative Agriculture 2026) provides a timely and comprehensive synthesis of th... The recent review article "Green agriculture enabled by versatile metal-organic frameworks:A review" by Wan et al.(Journal of Integrative Agriculture 2026) provides a timely and comprehensive synthesis of the rapidly evolving role of metal-organic frameworks(MOFs) in addressing the pressing challenges of modern agriculture.As the global population grows and environmental degradation intensifies,the quest for sustainable agricultural practices has never been more urgent.This review not only catalogues the impressive versatility of MOFs but also frames their application within the broader paradigms of green chemistry,circular economy,and smart farming. 展开更多
关键词 green chemistry smart farming integrative agriculture green agriculture circular economy sustainable agriculture sustainable agricultural practices metal organic frameworks
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Molecular composition of water soluble fraction of petroleum products and crude oils:Insights into groundwater contamination potential and environmental forensics 认领 引用 被引量：2
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作者 Wang Yu Yuruo Wan +3 位作者 Wei Zhou Jiayi An Liting Tian Jie Ma 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第1期437-444,共8页
Petroleum leakage is a major groundwater contamination source,with chemical composition of water soluble fractions(WSFs)from diverse oil sources significantly impacting groundwater quality and source identification.Th... Petroleum leakage is a major groundwater contamination source,with chemical composition of water soluble fractions(WSFs)from diverse oil sources significantly impacting groundwater quality and source identification.The aim of this study was to assess impact of 15 diverse oils on groundwater quality and environmental forensics based on oil-water equilibrium experiments.Our results indicate that contamination of groundwater by gasoline and naphtha is primarily attributed to volatile hydrocarbons,while pollution from diesel,kerosene,and crude oil is predominantly from non-hydrocarbons.Rapid determination of the extent of non-hydrocarbon pollution in WSFs was achieved through a new quantitative index.Gasoline and naphtha exhibited the highest groundwater contamination potential while kerosene and light crude oils were also likely to cause groundwater contamina-tion.Although volatile hydrocarbons in the WSFs of diesel and jet fuel do not easily exceed current regulatory standards,unregulated non-hydrocarbons may pose a more severe contamination risk to groundwater.Notably,the presence of significant benzene and toluene,hydrogenation and alkylation products(e.g.,C4-C5 alkylben-zenes,alkylindenes,alkyltetralins,and dihydro-indenes),cycloalkanes in WSFs can effectively be utilized for preliminary source identification of light distillates,middle distillates,and crude oils,respectively. 展开更多
关键词 Petroleum hydrocarbons Water soluble fraction Contaminated sites Groundwater contamination Source identification
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