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Tumor Microenvironment-responsive Self-immolative Polymers for Cancer Imaging and Therapy 认领 引用
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作者 Ihsan Ullah Wen-Jun Yang +2 位作者 Ye Liu Ci-Long Chu Youyong Yuan 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2026年第7期2112-2135,共24页
Self-immolative polymers(SIPs)have recently emerged as a distinct class of stimuli-responsive materials that undergo programmed domino-like degradation in response to specific biochemical triggers.The unique biochemic... Self-immolative polymers(SIPs)have recently emerged as a distinct class of stimuli-responsive materials that undergo programmed domino-like degradation in response to specific biochemical triggers.The unique biochemical characteristics of the tumor microenvironment(TME)include acidic pH,elevated glutathione(GSH)levels,excessive reactive oxygen species(ROS),dysregulated enzymes,and hypoxia.TMEresponsive SIPs have attracted significant attention for precise cancer imaging and therapy.By integrating labile linkages and modular structural design,these polymers can amplify weak biochemical signals into robust responses,enabling controlled drug release,signal amplification in imaging,and multifunctional theranostics.Compared with conventional responsive systems,SIP-based nanoplatforms offer enhanced sensitivity,tunable degradation kinetics,and the potential for sequential or cascade activation.In this review,we provide a comprehensive overview of the design principles,activation mechanisms,and functional applications of TME-responsive SIPs.We highlight representative strategies for their use in targeted drug delivery,tumor imaging,and synergistic therapeutic approaches and discuss the incorporation of emerging modalities such as near-infrared II(NIR-II)imaging and combination immunotherapy.Finally,we outline the major challenges and opportunities for advancing SIP-based nanomedicines for clinical translation and offer perspectives on how this rapidly evolving field may reshape the future of precision cancer diagnosis and treatment. 展开更多
关键词 Tumor microenvironment Self-immolative polymers Stimuli-responsive polymers Drug delivery systems Theranostics Cancer therapy
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Early-onset hepatic fibrosis linking to a novel PYROXD2 mutation:A case report 认领 引用
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作者 Zhen-Yao Jiang Rong-Qiang Liu +5 位作者 Meng-Juan Tang Han-Dong Fan Wen-Jun Yang Ling Gong Xiao-Xiao Mi Jun-Ping Shi 《World Journal of Hepatology》 2026年第5期303-312,共10页
BACKGROUND Early-onset liver fibrosis is predominantly driven by inherited genetic mutations that disrupt critical metabolic or structural pathways in the liver.Pyridine nucleotide-disulfide oxidoreductase domain 2(PY... BACKGROUND Early-onset liver fibrosis is predominantly driven by inherited genetic mutations that disrupt critical metabolic or structural pathways in the liver.Pyridine nucleotide-disulfide oxidoreductase domain 2(PYROXD2)(formerly named YueF)is a mitochondrial inner membrane/matrix-localized protein,regulating mitochondrial respiratory chain function.While emerging evidence highlights the role of PYROXD2 in mitochondrial redox homeostasis and respiratory chain integrity,its pathological contribution to early-onset liver fibrosis remains poorly characterized,particularly in the context of monogenic metabolic disorders and oxidative stress-mediated hepatocyte injury.CASE SUMMARY This report represents the first description of early-onset liver fibrosis in a patient harboring a heterozygous variant in the PYROXD2 gene.The patient presented with severe obesity,recurrent abnormalities in liver enzyme levels,and hyperuricemia,and demonstrated a suboptimal or absent response to hepatoprotective therapies.Wholeexome sequencing followed by Sanger validation identified a frameshift variant in the PYROXD2 gene(NM_032709.3,c.1082dupT,p.Phe361 Leu fs*50)in the affected patient.The variant was absent from population databases(gnomAD,1000 Genomes)and had not been previously reported in the literature.Computational pathogenicity predictions consistently classified it as pathogenic.Protein modeling using SWISS-MODEL indicated that the variant induces deleterious conformational alterations.CONCLUSION Collectively,the present case highlights PYROXD2 as a novel candidate gene,contributing to early-onset liver fibrogenesis.The identification of this variant in the PYROXD2 gene in the patient demonstrates a previously unrecognized molecular pathway in juvenile hepatic fibrosis,with potential implications for personalized diagnosis and treatment. 展开更多
关键词 Early-onset liver fibrosis PYROXD2 Obesity Hyperuricemia Frameshift mutation Mitochondrial dysfunction Metabolic disorder Case report
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Noise Reduction Method for Radio Astronomy Single Station Observation Based on Wavelet Transform and Mathematical Morphology 认领 引用 被引量：1
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作者 Ming-Wei Qin Rui Tang +8 位作者 Ying-Hui Zhou Chang-Jun Lan Wen-Hao Fu Huan Wang Bao-Lin Hou Zamri Bin Zainal Abidin Jin-Song Ping Wen-Jun Yang Liang Dong 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2025年第7期148-166,共19页
The 21 cm radiation of neutral hydrogen provides crucial information for studying the early universe and its evolution.To advance this research,countries have made significant investments in constructing large lowfreq... The 21 cm radiation of neutral hydrogen provides crucial information for studying the early universe and its evolution.To advance this research,countries have made significant investments in constructing large lowfrequency radio telescope arrays,such as the Low Frequency Array and the Square Kilometre Array Phase 1 Low Frequency.These instruments are pivotal for radio astronomy research.However,challenges such as ionospheric plasma interference,ambient radio noise,and instrument-related effects have become increasingly prominent,posing major obstacles in cosmology research.To address these issues,this paper proposes an efficient signal processing method that combines wavelet transform and mathematical morphology.The method involves the following steps:Background Subtraction:Background interference in radio observation signals is eliminated.Wavelet Transform:The signal,after removing background noise,undergoes a two-dimensional discrete wavelet transform.Threshold processing is then applied to the wavelet coefficients to effectively remove interference components.Wavelet Inversion:The processed signal is reconstructed using wavelet inversion.Mathematical Morphology:The reconstructed signal is further optimized using mathematical morphology to refine the results.Experimental verification was conducted using solar observation data from the Xinjiang Observatory and the Yunnan Observatory.The results demonstrate that this method successfully removes interference signals while preserving useful signals,thus improving the accuracy of radio astronomy observations and reducing the impact of radio frequency interference. 展开更多
关键词 methods:data analysis techniques:image processing techniques:spectroscopic Sun:radio radiation methods:numerical
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A nomogram based on age, prostate-specific antigen level, prostate volume and digital rectal examination for predicting risk of prostate cancer 认领 引用 被引量：22
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作者 Ping Tang Hui Chen +5 位作者 Matthew Uhlman Yu-Rong Lin Xiang-Rong Deng Bin Wang Wen-Jun Yang Ke-Ji Xie 《Asian Journal of Andrology》 SCIE CAS CSCD 2013年第1期129-133,共5页
Nomograms for predicting the risk of prostate cancer developed using other populations may introduce sizable bias when applied to a Chinese cohort. In the present study, we sought to develop a nomogram for predicting ... Nomograms for predicting the risk of prostate cancer developed using other populations may introduce sizable bias when applied to a Chinese cohort. In the present study, we sought to develop a nomogram for predicting the probability of a positive initial prostate biopsy in a Chinese population. A total of 535 Chinese men who underwent a prostatic biopsy for the detection of prostate cancer in the past decade with complete biopsy data were included. Stepwise logistic regression was used to determine the independent predictors of a positive initial biopsy. Age, prostate-specific antigen （PSA）, prostate volume （PV）, digital rectal examination （DRE） status, % free PSA and transrectal ultrasound （TRUS） findings were included in the analysis. A nomogram model was developed that was based on these independent predictors to calculate the probability of a positive initial prostate biopsy. A receiver-operating characteristic curve was used to assess the accuracy of using the nomogram and PSA levels alone for predicting positive prostate biopsy. The rate for positive initial prostate biopsy was 41.7% （223/535）. The independent variables used to predict a positive initial prostate biopsy were age, PSA, PV and DRE status. The areas under the receiver-operating characteristic curve for a positive initial prostate biopsy for PSA alone and the nomogram were 79.7% and 84.8%, respectively. Our results indicate that the risk of a positive initial prostate biopsy can be predicted to a satisfactory level in a Chinese population using our nomogram. The nomogram can be used to identify and counsel patients who should consider a prostate biopsy, ultimately enhancing accuracy in diagnosing prostate cancer. 展开更多
关键词 nomogram prediction prostate biopsy prostate cancer prostate-specific antigen （PSA） prostate volume （PV） age digital rectal examination （DRE）
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Effects of nuclear factor-kappaB on rat hepatocyte regeneration and apoptosis after 70% portal branch ligation 认领 引用 被引量：7
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作者 Wen-Jun Yang Qi-Yu Zhang +6 位作者 Zheng-Ping Yu Qi-Tong Song Hua-Ping Liang Xiang Xu Guan-Bao Zhu Fei-Zhao Jiang Hong-Qi Shi 《World Journal of Gastroenterology》 SCIE CAS 2005年第43期6775-6779,共5页
AIM： To detect the DNA binding activity of nuclear factor-kappaB （NF-KB） in rat hepatocyte and to investigate the effects of NF-KB on rat hepatocyte regeneration and apoptosis after 70% portal branch Iigation. METH... AIM： To detect the DNA binding activity of nuclear factor-kappaB （NF-KB） in rat hepatocyte and to investigate the effects of NF-KB on rat hepatocyte regeneration and apoptosis after 70% portal branch Iigation. METHODS： Sixty Wistar rats were randomly divided into control group and portal branch ligation group. The animals were killed 12 h, 1, 2, 3, 7, and 14 d after surgery to determine the contents of plasma ALT. Hepatocytes were isolated and nuclear protein was extracted. DNA binding activity of NF-KB was measured by ENSA. Hepatocyte regeneration and apoptosis were observed under microscope by TUNEL staining. The ultrastructural changes of liver were observed under electron microscope. RESULTS： Seventy percent portal branch ligation produced atrophy of the ligated lobes and the perfused lobes underwent compensatory regeneration, the total liver weight and plasma ALT levels were maintained at the level of sham-operated animals throughout the experiment. After 2 d of portal branch ligation, DNA binding activity of NF-KB in hepatocyte increased and reached its peak, the number of apoptotic hepatocyte in the ligated lobes and the number of mitotic hepatocyte in the perfused lobes also reached their peak. Typical apoptotic changes and evident fibrotic changes in the ligated lobes were observed under electron microscope. CONCLUSION： After 70% portal branch ligation, DNA binding activity of NF-KB in hepatocyte is significantly increased and NF-KB plays an important role in hepatocyte regeneration and apoptosis. 展开更多
关键词 Portal branch ligation Nuclear factor-kappaB Regeneration Apoptosis
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East Asian VLBI Network observations of active galactic nuclei jets:imaging with KaVA+Tianma+Nanshan 认领 引用
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作者 Yu-Zhu Cui Kazuhiro Hada +74 位作者 Motoki Kino Bong-Won Sohn Jongho Park Hyun-Wook Ro Satoko Sawada-Satoh Wu Jiang Lang Cui Mareki Honma Zhi-Qiang Shen Fumie Tazaki Tao An Ilje Cho Guang-Yao Zhao Xiao-Peng Cheng Kotaro Niinuma Kiyoaki Wajima Ying-Kang Zhang Noriyuki Kawaguchi Juan-Carlos Algaba Shoko Koyama Tomoya Hirota Yoshinori Yonekura Nobuyuki Sakai Bo Xia Yong-Bin Jiang Lin-Feng Yu Wei Gou Ju-Yeon Hwang Yong-Chen Jiang Yun-Xia Sun Dong-Kyu Jung Hyo-Ryoung Kim Jeong-Sook Kim Hideyuki Kobayashi Jee-Won Lee Jeong-Ae Lee Hua Zhang Guang-Hui Li Zhi-Qiang Xu Peng Li Jung-Hwan Oh Se-Jin Oh Chung-Sik Oh Tomoaki Oyama Duk-Gyoo Roh Katsunori-M.Shibata Wen Guo Rong-Bing Zhao Wei-Ye Zhong Jin-Qing Wang Wen-Jun Yang Hao Yan Jae-Hwan Yeom Bin Li Xiao-Fei Li Jian-Ping Yuan Jian Dong Zhong Chen Kazunori Akiyama Keiichi Asada Do-Young Byun Yoshiaki Hagiwara Jeffrey Hodgson Tae-Hyun Jung Kee-Tae Kim Sang-Sung Lee Kunwoo Yi Qing-Hui Liu Xiang Liu Ru-Sen Lu Masanori Nakamura Sascha Trippe Na Wang Xue-Zheng Wang Bo Zhang 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2021年第8期220-234,共15页
The East Asian Very Long Baseline Interferometry(VLBI) Network(EAVN) is a rapidly evolving international VLBI array that is currently promoted under joint efforts among China,Japan and Korea.EAVN aims at forming a joi... The East Asian Very Long Baseline Interferometry(VLBI) Network(EAVN) is a rapidly evolving international VLBI array that is currently promoted under joint efforts among China,Japan and Korea.EAVN aims at forming a joint VLBI Network by combining a large number of radio telescopes distributed over East Asian regions.After the combination of the Korean VLBI Network(KVN) and the VLBI Exploration of Radio Astrometry(VERA) into Ka VA,further expansion with the joint array in East Asia is actively promoted.Here we report the first imaging results(at 22 and 43 GHz) of bright radio sources obtained with Ka VA connected to Tianma 65-m and Nanshan 26-m Radio Telescopes in China.To test the EAVN imaging performance for different sources,we observed four active galactic nuclei(AGN) having different brightness and morphology.As a result,we confirmed that the Tianma 65-m Radio Telescope(TMRT) significantly enhances the overall array sensitivity,a factor of 4 improvement in baseline sensitivity and 2 in image dynamic range compared to the case of Ka VA only.The addition of the Nanshan 26-m Radio Telescope(NSRT) further doubled the east-west angular resolution.With the resulting high-dynamic-range,high-resolution images with EAVN(Ka VA+TMRT+NSRT),various fine-scale structures in our targets,such as the counter-jet in M87,a kink-like morphology of the 3 C 273 jet and the weak emission in other sources are successfully detected.This demonstrates the powerful capability of EAVN to study AGN jets and to achieve other science goals in general.Ongoing expansion of EAVN will further enhance the angular resolution,detection sensitivity and frequency coverage of the network. 展开更多
关键词 galaxies:active galaxies:jets instrumentation:interferometers radio continuum:galaxies
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Hepatopulmonary metastases from papillary thyroid microcarcinoma:A case report 认领 引用 被引量：1
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作者 Chuan-Yu Yang Xuan-Wu Chen +4 位作者 Dong Tang Wen-Jun Yang Xiao-Xiao Mi Jun-Ping Shi Wei-Dong Du 《World Journal of Clinical Cases》 SCIE 2022年第14期4661-4668,共8页
BACKGROUND Papillary thyroid carcinoma(PTC)is the most common endocrine malignancy.Papillary thyroid microcarcinoma(PTMC)accounts for the majority of PTC cases.However,concurrent pulmonary and hepatic metastases of PT... BACKGROUND Papillary thyroid carcinoma(PTC)is the most common endocrine malignancy.Papillary thyroid microcarcinoma(PTMC)accounts for the majority of PTC cases.However,concurrent pulmonary and hepatic metastases of PTMC are rarely seen.Here,we present a patient with coexisting liver and lung metastases from PTMC.CASE SUMMARY We describe a 26-year-old woman with PTMC with multiple concurrent metastases.After 3 d of unexplained fever,she was admitted to our hospital.Her thyroid functional tests were abnormal.Her positron emission tomography(PET)/magnetic resonance imaging(MRI)examination showed increased fluorodeoxyglucose(FDG)metabolism and space-occupying lesions in the left lobe of the thyroid.Additionally,PET/MRI images revealed multiple nodules in the lung and liver with increased FDG metabolism.Chest computer tomography(CT)showed multiple pulmonary metastases.Abdominal ultrasound and liver MRI showed multiple space-occupying lesions in the liver.The patient underwent total thyroidectomy and central lymph node dissection.Postoperative pathological analysis showed a papillary microcarcinoma multiplex in the left lobe of the thyroid.A diagnosis of hepatopulmonary metastases from papillary thyroid microcarcinoma was made.The patient was given iodine-131 treatment one year after the surgery.She recovered well after the operation,and the incision healed well.After discharge,she was treated with oral levothyroxine sodium tablets,and symptomatic and supportive treatments were also given to promote radioactive excretion and prevent bone marrow suppression by iodine-131 treatment.CONCLUSION Since patients with thyroid cancer concurrent with hepatopulmonary metastases have rarely been reported,our case will highlight the clinical and pathological profiles of these patients. 展开更多
关键词 Papillary thyroid microcarcinoma Distant metastasis Liver Lung Case report
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A Novel Low-frequency Radio Astronomical Observation Array(1~90 MHz)and its First Light 认领 引用
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作者 Wen-Jun Yang Zhen Wang +9 位作者 Ming-Yuan Wang Fa-Bao Yan Guang Lu Guan-Nan Gao Shao-Jie Guo Yu-Mei Shen Bing-Qiang Xu Yu Bai Yong Chen Jin-Song Ping 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2023年第12期96-104,共9页
The extremely low frequency(f<40 MHz)is a very important frequency band for modern radio astronomy observations.It is also a key frequency band for solar radio bursts,planetary radio bursts,fast radio bursts detect... The extremely low frequency(f<40 MHz)is a very important frequency band for modern radio astronomy observations.It is also a key frequency band for solar radio bursts,planetary radio bursts,fast radio bursts detected in the lunar space electromagnetic environment,and the Earth’s middle and upper atmosphere with low dispersion values.In this frequency band,the solar stellar activity,the early state of the universe,and the radiation characteristics of the planetary magnetosphere and plasma layer can be explored.Since there are few observations with effective spatial resolution in the extremely low frequency,it is highly possible to discover unknown astronomical phenomena on such a band in the future.In conjunction with low frequency radio observation on the far side of the Moon,we initially set up a novel low-frequency radio array in the Qitai station of Xinjiang Astronomical Observatory deep in Tianshan Mountains,Xinjiang,China on 2021 August 23.The array covers an operating frequency range of 1~90 MHz with a sensitivity of-78 dBm/125kHz,a dynamic range of 72 dB,and a typical gain value of 6 dBi,which can realize unattended all-weather observations.The two antennas due south of the Qitai Low-Frequency Radio Array were put into trial observations on 2021 May 28,and the very quiet electromagnetic environment of the station has been confirmed.So far,many solar radio bursts and other foreign signals have been detected.The results show that this novel low frequency radio array has the advantages of good performance,strong direction,and high antenna efficiency.It can play a unique role in Solar Cycle 25,and has a potential value in prospective collaborative observation between the Earth and space for extremely low frequency radio astronomy. 展开更多
关键词 The Sun-Astronomical Instrumentation-Methods and Techniques-Stars-Planetary Systems
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显微镜结肠炎临床特征及其相关危险因素分析 认领 引用 被引量：2
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作者 吴蓉 李国熊 +4 位作者 杨文君 李丽 陈晶 周刚 方家恒 《中国内镜杂志》 北大核心 2017年第11期101-105,共5页
目的分析慢性腹泻患者的临床、内镜及病理资料,探讨可能影响显微镜结肠炎(MC)的危险因素。方法前瞻性分析2016年6月-2017年4月该院门诊以水样腹泻为主诉患者的临床资料,常规结肠镜检查,多点取肠黏膜活检,行组织病理HE染色和Masson染色,... 目的分析慢性腹泻患者的临床、内镜及病理资料,探讨可能影响显微镜结肠炎(MC)的危险因素。方法前瞻性分析2016年6月-2017年4月该院门诊以水样腹泻为主诉患者的临床资料,常规结肠镜检查,多点取肠黏膜活检,行组织病理HE染色和Masson染色,对患者的病史及病理进行分析。结果 102例水样腹泻患者中诊断为MC 3例(3/102,2.94%),其中胶原性结肠炎(CC)3例,全部为女性,年龄24~36岁,淋巴细胞性结肠炎(LC)0例。结肠镜下肠黏膜基本正常或仅表现为轻度的充血水肿;病理组织学表现为上皮细胞损伤,上皮内淋巴细胞增多,固有层炎症细胞浸润,上皮下胶原带增厚。近期服用降糖药、质子泵抑制剂(PPIs)、面食等因素可能与MC发病关系密切。结论 MC是慢性水样腹泻的重要原因,临床症状及结肠镜表现均无特异性,慢性腹泻患者应尽早行结肠镜下多点活检明确诊断,其发病可能与使用某些药物(如降糖药、PPIs)和某些食物(面筋)有关。 展开更多
关键词 显微镜结肠炎 淋巴细胞性结肠炎 胶原性结肠炎 面筋
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Phase Ⅲ trial of docetaxel cisplatin 5-fluorouracil induction chemotherapy for resectable oral cancer suggests favorable pathological response as a surrogate endpoint for good therapeutic outcome 认领 引用 被引量：4
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作者 Wu-tong Ju Ying Liu +13 位作者 Li-zhen Wang Jiang Li Guo-xing Ren Jian Sun Wen-yong Tu Yong-jie Hu Tong Ji Wen-jun Yang Jun Li Yue He Yan-an Wang Chen-ping Zhang Lai-ping Zhong Zhi-yuan Zhang 《Cancer Communications》 SCIE 2021年第3期279-283,共5页
Dear Editor,Induction chemotherapy has been utilized for decades in locally advanced head and neck squamous cell carcinoma(HNSCC).The docetaxel,cisplatin,5-fluorouracil(TPF)regimen is the most recommended induction ch... Dear Editor,Induction chemotherapy has been utilized for decades in locally advanced head and neck squamous cell carcinoma(HNSCC).The docetaxel,cisplatin,5-fluorouracil(TPF)regimen is the most recommended induction chemotherapy regimen forHNSCC and oral squamous cell carcinoma(OSCC)[1].However,our initial phase Ⅲ trial failed to demonstrate a significant survival benefit of TPF induction chemotherapy in patients with locally advanced OSCC[2]. 展开更多
关键词 chemotherapy cisplatin regimen
A Character Flow Framework for Multi-Oriented Scene Text Detection 认领 引用 被引量：1
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作者 Wen-Jun Yang Bei-Ji Zou +1 位作者 Kai-Wen Li Shu Liu 《Journal of Computer Science & Technology》 SCIE EI CSCD 2021年第3期465-477,共13页
Scene text detection plays a significant role in various applications,such as object recognition,document management,and visual navigation.The instance segmentation based method has been mostly used in existing resear... Scene text detection plays a significant role in various applications,such as object recognition,document management,and visual navigation.The instance segmentation based method has been mostly used in existing research due to its advantages in dealing with multi-oriented texts.However,a large number of non-text pixels exist in the labels during the model training,leading to text mis-segmentation.In this paper,we propose a novel multi-oriented scene text detection framework,which includes two main modules:character instance segmentation(one instance corresponds to one character),and character flow construction(one character flow corresponds to one word).We use feature pyramid network(FPN)to predict character and non-character instances with arbitrary directions.A joint network of FPN and bidirectional long short-term memory(BLSTM)is developed to explore the context information among isolated characters,which are finally grouped into character flows.Extensive experiments are conducted on ICDAR2013,ICDAR2015,MSRA-TD500 and MLT datasets to demonstrate the effectiveness of our approach.The F-measures are 92.62%,88.02%,83.69%and 77.81%,respectively. 展开更多
关键词 multi-oriented scene text detection character instance segmentation character flow feature pyramid network(FPN) bidirectional long short-term memory(BLSTM)
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Lung Cancer with Diffuse Ground-glass Shadow in Two Lungs and Respiratory Failure 认领 引用
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作者 Zhe-Min Feng Zhen-Jie Zhuang +3 位作者 Wen-Bo He Jian-Ping Ding Wen-Jun Yang Xue-Yuan Chen 《Chinese Medical Journal》 SCIE CAS CSCD 2016年第15期1873-1876,共4页
INTRODUCTION Pulmonary ground-glass shadow is a common clinical imaging manifestation shared by many pulmonary diseases such as interstitial pneumonia, pulmonary fungal infection, parasitic infection, viral pneumonia,... INTRODUCTION Pulmonary ground-glass shadow is a common clinical imaging manifestation shared by many pulmonary diseases such as interstitial pneumonia, pulmonary fungal infection, parasitic infection, viral pneumonia, and heart failure. Some of the lung cancers, especially lung adenocarcinoma, 展开更多
关键词 Diffuse Ground-glass Shadow Lung Cancer
Analysis of the spanwise vortex of open channel flows based on the Omega-Liutex vortex identification method 认领 引用 被引量：4
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作者 Bin Li Wen-jun Yang +2 位作者 Jie Li Si-yu Jing Yue Chen 《Journal of Hydrodynamics》 SCIE EI CSCD 2022年第1期148-155,共8页
In this paper, a particle imaging velocimetry (PIV) system of high-temporal-spatial resolution is used to investigate the spanwise vortex distribution of fully developed turbulent flows in an open channel and its rela... In this paper, a particle imaging velocimetry (PIV) system of high-temporal-spatial resolution is used to investigate the spanwise vortex distribution of fully developed turbulent flows in an open channel and its relationship with the turbulence. The distributions of the time-averaged velocity, the turbulence intensity and the Reynolds stress are obtained in the longitudinal profile. The third-generation vortex identification method (based on the Omega-Liutex vector) is applied to accurately identify and analyze the vortex in the spanwise direction. The results suggest that the vortex density increases with the Reynolds number at a given aspect ratio (B / H) of the flow. The distribution trend of the spanwise vortex density in the vertical direction remains unchanged for different discharges. Specifically, the vortex density increases along the vertical direction and reaches the peak at y / H = 0.15, then decreases and reaches the bottoms at the flow surface. 展开更多
关键词 Open channel turbulent flows spanwise vortex Reynolds number particle imaging velocimetry(PIV) aspect ratio
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