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Bioinspired Ultrastrong and Ion-Selective Gel Electrolytes by Interfacial Coacervation for High-Performance Lithium-Metal Batteries 认领 引用 被引量：1
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作者 Dong Lv Xin Huang +5 位作者 Xin Li Lingyu Zhu Jingchao Chai Yuanxin Gao Zhihong Liu Xi Yao 《Carbon Energy》 SCIE EI CAS CSCD 2026年第4期238-249,共12页
Coupling lithium metal with gel polymer electrolytes(GPEs)has been demonstrated as an effective strategy to enable stable lithium metal batteries(LMBs).However,the current design of GPEs faces difficulties in simultan... Coupling lithium metal with gel polymer electrolytes(GPEs)has been demonstrated as an effective strategy to enable stable lithium metal batteries(LMBs).However,the current design of GPEs faces difficulties in simultaneously achieving satisfactory mechanical properties and efficient and selective ion transport.Here,we present the fabrication of ultrastrong and hierarchically nanoporous cellulose gel electrolytes via poly(ionic liquid)-induced interfacial coacervation of cellulose nanofibrils.The nanofibrils GPE with a cascade ion-conduction network spanning from molecular-scale channels to mesopores enables dualmode Li+transport through nanoconfinement and interstitial ion hopping.This mechanism effectively blocks anion movement while achieving selective Li+transport with a high transference number of 0.7 and a high ionic conductivity of 0.65 mS cm-1.The GPE enables stable cycling of high mass loading(LiFePO4,16 mg cm-2)LMBs and high-temperature(80℃)LMBs.Specifically,the LMB with a high LiFePO4loading of 12 mg cm-2delivers stable cycling life over 600 cycles,maintaining 87%capacity retention.Furthermore,the assembled 635 mAh pouch full cell demonstrates excellent stability with a high capacity retention of 91.7%after 1500 cycles.This study offers a novel strategy for the development of robust and ion-selective GPEs for stable LMBs. 展开更多
关键词 cellulose nanofibrils gel polymer electrolytes high strength interfacial coacervation ion selectivity
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Cropping alfalfa for 18 years increases importance of fungi in multi-kingdom networks in saline-alkali soils 认领 引用
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作者 Dan ZHU Bin LI +5 位作者 Lun AO Xiaoqian LIU Mengmeng ZHANG Guangyu SUN Junnan DING Xin LI 《Pedosphere》 SCIE CAS CSCD 2026年第3期802-817,共16页
Soil salinization has become a significant global ecological and resource problem.Alfalfa cropping has been recognized as an effective method for improving soil fertility and promoting the sustainable growth of agricu... Soil salinization has become a significant global ecological and resource problem.Alfalfa cropping has been recognized as an effective method for improving soil fertility and promoting the sustainable growth of agricultural ecosystems.In this study,an 18-year-old alfalfa cultivation area within the saline-alkali Songnen Plain in Northeast China was selected to determine the contribution of the microbial network to the improvement of saline-alkali soils after alfalfa cropping.Our findings indicated that the multi-kingdom microbial network,comprising fungi,bacteria,and archaea,was more complex and stable than the single-kingdom networks.Specifically,the multi-kingdom network exhibited an increased number of nodes and connections,demonstrating higher complexity.By cultivating alfalfa in saline-alkali soils,fungal nodes in the multi-kingdom network demonstrated significantly higher degree and betweenness compared to bacterial nodes and archaeal nodes.Additionally,fungi had a higher natural connectivity,which contributed to the overall network stability.In contrast,the bacterial subset in the multi-kingdom network in bare land exhibited a higher degree,betweenness,and natural connectivity.Furthermore,changes in the topological properties of the microbial network,including its complexity and stability,were significantly correlated with environmental factors,such as soil electrical conductivity and pH.In conclusion,cultivating alfalfa stabilized the self-organization in the multi-kingdom network in saline-alkaline soils and increased the complexity and stability of the fungal network.These findings provide a foundation for further research into the role of multi-kingdom microbial communities in soil ecosystems. 展开更多
关键词 microbial community microbial co-occurrence network network stability phytoremediation single-kingdom network soil salinization Songnen Plain topological property
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Integrating AI-driven single-cell analysis to decode epithelial heterogeneity: A prognostic signature and translational immunotherapy strategy targeting KRT18-induced PD-L1 in lung adenocarcinoma 认领 引用
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作者 Han Zhang Jun Zhou +5 位作者 Jiwei Liu Pengpeng Zhang Xin Li Yue Yu Wenjun Mao Daqiang Sun 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2026年第2期177-196,共20页
Objective: The heterogeneity of epithelial cells and their interaction with the immune microenvironment play crucial roles in tumor progression, but the underlying mechanisms remain unclear.Methods: We analyzed single... Objective: The heterogeneity of epithelial cells and their interaction with the immune microenvironment play crucial roles in tumor progression, but the underlying mechanisms remain unclear.Methods: We analyzed single-cell transcriptomic data from normal and tumor tissues to characterize epithelial cells and their microenvironment. Key genes were identified and used, via survival analysis and multiple machine learning methods, to construct a prognostic model termed the Epithelial Signature(EpiSig). We further validated,through a series of experiments, the critical immunological roles of the key genes incorporated into the EpiSig model.Results: Tumor tissues showed a marked increase in epithelial cells, a reduction in natural killer(NK)/T cells,and cell co-occurrence patterns distinct from normal tissues. We identified differentially expressed genes in tumor epithelial cells and integrated multiple machine-learning algorithms to construct the EpiSig model. This model effectively stratified patient prognosis, with the high-EpiSig group exhibiting significantly worse survival;receiver operator characteristic curve(ROC) and principal component analysis(PCA) analyses further supported its accuracy and robustness. Immune analyses indicated lower immune cell infiltration, decreased human leukocyte antigen(HLA) expression, and elevated programmed cell death ligand 1/programmed cell death protein 1(PDL1/PD-1) in the high-EpiSig group, reflecting a more pronounced immunosuppressive microenvironment. The core gene KRT18 correlated strongly with EpiSig scores(R=0.65) and promoted lung adenocarcinoma(LUAD) cell proliferation in functional assays. Further, low KRT18 tumors showed higher CD4+/CD8+ T cell and CD20+ B cell infiltration;in a mouse LLC subcutaneous tumor model, both Krt18 knockdown and PD-1 blockade suppressed tumor growth, with greater efficacy in combination. Mechanistically, KRT18 activated NF-kB/p65 to upregulate PD-L1, promoting immune exclusion and impairing T-cell effector function.Conclusions: This study highlights the close relationship between epithelial cell heterogeneity and immune microenvironment alterations in tumors, and presents the EpiSig as a robust tool for prognostic prediction. KRT18may serve as a promising therapeutic target in LUAD. 展开更多
关键词 Epithelial heterogeneity immune microenvironment single-cell transcriptomics prognostic model lung adenocarcinoma
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Enterococcus hirae QT4713 alleviated DSS-induced colitis by modulating gut microbiota and tryptophan metabolism in mice 认领 引用
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作者 Xueni Fan Zhenjiang Liu +7 位作者 Wei Liu Diantong Li Tingting Zhao Dongxu Wen Xin Li Qi Wang Bin Li Xiaodan Huang 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第4期1905-1919,共15页
Probiotics are known to alleviate inflammatory bowel disease,and their precise mechanisms remain unclear.In this study,we identified a strain of Enterococcus hirae QT4713,isolated from the Tibetan plateau,that exhibit... Probiotics are known to alleviate inflammatory bowel disease,and their precise mechanisms remain unclear.In this study,we identified a strain of Enterococcus hirae QT4713,isolated from the Tibetan plateau,that exhibited high anti-inflammatory activity in vitro.After confirming its tolerance to gastrointestinal fluids and safety,we evaluated the effect of E.hirae QT4713 on IBD using a dextran sulfate sodium(DSS)-induced colitis mouse model and analyzed the microbial response through metagenomic and metabolomics.The results indicated that E.hirae QT4713 alleviated colitis symptoms by reducing oxidative stress in the serum and inflammatory cytokine levels in colonic tissue,particularly IL-1β(P<0.05).It also reduced structural damage,inflammatory infiltration,and epithelial cell apoptosis in the colon.Additionally,the strain increased the expression of MUC-2 and occludin in colonic tissue,which helped to protect the colonic barrier.Furthermore,intervention with E.hirae QT4713 enriched beneficial bacteria such as Bifidobacteria and Lactobacillus,increased the levels of butyric acid and propionic acid in the gut(P<0.05),regulated tryptophan metabolism,and promoted the production of its indole derivatives,including 3-indoleacetonitrile,3-indoleacrylic acid,and indole-3-lactic acid(P<0.05),thus alleviating colitis.These findings provide new insights into how probiotics,such as E.hirae QT4713,alleviated colitis in a gut microbiotaryptophan metabolism-dependent manner. 展开更多
关键词 Probiotic Anti-inflammatory Colitis Gut microbiota Tryptophan metabolism
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A theoretical model to predict the elastic response of simply supported cylindrical shell under inner blast 认领 引用
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作者 Chuanqing Chen Hao Lu +3 位作者 Jiaqun Wang Guangfa Gao Xin Li Mingyang Wang 《Acta Mechanica Sinica》 SCIE EI CAS CSCD 2026年第3期274-300,共27页
This paper presents a theoretical model designed to predict the elastic response of simply supported cylindrical shells under internal explosion loads at arbitrary positions along the central axis.The model accounts f... This paper presents a theoretical model designed to predict the elastic response of simply supported cylindrical shells under internal explosion loads at arbitrary positions along the central axis.The model accounts for the propagation and attenuation effects of explosion waves over time and space.To accurately capture the varying impact area of the blast on the shell wall,the explosion wave function is divided into three distinct stages.By integrating classical shell theory and applying the Laplace transform solution method,the model provides an effective means of calculating the dynamic displacement response.The accuracy of the theoretical model is validated through finite element simulations across various cylinder radii.The strong agreement between theoretical and numerical results demonstrates the robustness of the model across a wide range of applications.This work provides a fundamental understanding of the dynamic behavior of cylindrical shells under internal blast loading,essential for enhancing safety and reliability in engineering applications. 展开更多
关键词 Cylindrical shell Internal blast loading Elastic response Theoretical model
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From Lab to Market:Strategies for Stabilizing and Scaling Perovskite Solar Cells via Printing Technologies 认领 引用
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作者 Xin Li Sikandar Aftab +4 位作者 Manesh Ashok Yewale Hosameldin Helmy Hegazy Erdi Akman Najaf Rubab Mahmut Kus 《Energy & Environmental Materials》 SCIE EI CAS CSCD 2026年第1期275-301,共27页
Demonstrating significant achievements in efficiency,perovskite solar cells(PSCs)have acquired unique positions in photovoltaics,offering alternatives to conventional commercial silicon solar cells.While there has bee... Demonstrating significant achievements in efficiency,perovskite solar cells(PSCs)have acquired unique positions in photovoltaics,offering alternatives to conventional commercial silicon solar cells.While there has been significant progress in enhancing photovoltaic performance,obvious stability problems remain a primary challenge that continues to hinder the commercial viability of PSCs.This present review first comprehensively discusses the main challenges to the commercialization of PSCs,including stability problems,ion migration,toxicity,and complexities in large-scale fabrication.It then effectively presents universal strategies to overcome the mentioned problems.Moreover,this review article examines various printing techniques that can be used to improve PSCs,emphasizing their benefits like low-cost components and procedures.Several printing processes are covered in the discussion,such as slot-die coating,spray coating,inkjet printing,doctor-blade coating,roll-to-roll printing,and screen printing.The potential uses of PSCs for the implementation of greenhouses,building-integrated photovoltaic systems,and indoor light energy harvesting.These uses highlight the adaptability of PSCs and demonstrate their ability to transform energy production technologies.Additionally,this review highlights the special qualities of perovskite materials that present chances to surpass silicon solar cells'efficiency restrictions and get close to the Shockley-Queisser limit.In conclusion,the current review provides a brief overview of recent developments,existing challenges,and opportunities of PSCs.It provides a thorough understanding of the merits of highly efficient PSCs fabricated by adopting printing methods to tackle stability problems along with facile fabrication of PSCs using simplified and cost-effective strategies. 展开更多
关键词 commercialization large-scale perovskite solar cells perovskite solar cells printing methods
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Traction-preclosure-assisted vs conventional endoscopic fullthickness resection for gastric subepithelial tumors:Safety,efficacy in a retrospective cohort(with video) 认领 引用
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作者 Xin Li Ren-Yi Zhang +2 位作者 Xu-Dong Wen Xue-Qin Li Wei-Hui Liu 《World Journal of Gastroenterology》 SCIE CAS 2026年第19期12-25,共14页
BACKGROUND Gastric subepithelial tumors(SETs),commonly encountered in gastrointestinal practice,require precise and complete resection to prevent recurrence and malignant transformation.AIM To compare efficacy,safety,... BACKGROUND Gastric subepithelial tumors(SETs),commonly encountered in gastrointestinal practice,require precise and complete resection to prevent recurrence and malignant transformation.AIM To compare efficacy,safety,and clinical outcomes between traction-preclosure(TPC)-assisted endoscopic full-thickness resection(EFTR)and conventional EFTR for gastric SETs.METHODS We retrospectively analyzed 214 patients who underwent EFTR for gastric SETs,assigning them to the conventional EFTR(n=129)or TPC-EFTR(n=85)group.Primary outcomes were complete and en bloc resection rates.Secondary outcomes included procedural efficiency(operation time,closure time,time to resumption of diet and defecation),safety(adverse events,blood parameters,pneumoperitoneum),and clinical efficacy(pain scores,EuroQol visual analogue scale,health utility values,recurrence rate).Recurrence-free survival was assessed by KaplanMeier analysis.RESULTS Compared to the conventional EFTR group,the TPC-EFTR group had a higher complete resection rate(95.3%vs 86.8%,P=0.041),shorter operation time[60.0(40.0)minutes vs 70.0(39.5)minutes,P=0.047],shorter closure time(13.0±4.5 minutes vs 14.3±4.5 minutes,P=0.044),and lower pneumoperitoneum incidence(4.7%vs 14.0%,P=0.033).The TPC-EFTR group showed higher postoperative EuroQol visual analogue scale scores[79.9(7.6)vs 79.3(2.0),P=0.001]and health utility values[95.0(4.0)×10-2 vs 92.0(14.0)×10-2,P=0.002].Kaplan-Meier curves showed comparable median recurrence-free survival between the two groups[not reached(95%confidence interval:26.0-not reached)months vs 75.0(95%confidence interval:60.0-75.0)months,P=0.770].CONCLUSION TPC-EFTR is safe and effective strategy gastric SETs,enhancing procedural efficiency and postoperative quality of life while potentially achieving comparable or superior long-term oncological outcomes vs conventional EFTR. 展开更多
关键词 Gastric subepithelial tumors Endoscopic full-thickness resection Traction method Pre-closure technique Recurrence-free survival
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Adaptive rehabilitation training for vestibular semicircular canal injury based on virtual reality technology 认领 引用
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作者 Xiaohua Sun Chengwei Fan +7 位作者 Senzhe Xu Yueyao Fu Wenjing Chen Sichao Liang Qian Li Yi Fan Songhai Zhang Xin Li 《Journal of Otology》 CSCD 2026年第2期90-95,共6页
Objective To evaluate the clinical efficacy of an adaptive vestibular rehabilitation training system based on Virtual Reality(VR)technology for patients with semicircular canal injury.Methods A randomized controlled t... Objective To evaluate the clinical efficacy of an adaptive vestibular rehabilitation training system based on Virtual Reality(VR)technology for patients with semicircular canal injury.Methods A randomized controlled trial was conducted with 60 patients diagnosed with peripheral vestibular vertigo.Participants were randomly assigned to either an Intervention Group(n=30),which received VR-based adaptive vestibular rehabilitation using the PICO 4 Pro system,or a Control Group(n=30),which underwent traditional vestibular rehabilitation.Both groups received training for four weeks.The primary outcome measure was the Dizziness Handicap Inventory(DHI).Secondary outcomes included balance performance assessed via the Activities-specific Balance Confidence(ABC)Scale and static posturography(Maximum Sway Path Length and Sway Area).Vestibular function was objectively evaluated using the Video Head Impulse Test(vHIT)and the Bithermal Caloric Test.Psychological status was assessed using the Hospital Anxiety and Depression Scale(HADS).Results Post-intervention analysis revealed that the Intervention Group achieved significantly lower DHI scores compared to the Control Group.In terms of balance,the Intervention Group demonstrated significantly higher ABC Scale scores and reduced Maximum Sway Path Length and Sway Area compared to controls.Furthermore,the Intervention Group showed a significantly lower rate of abnormal findings in both vHIT and Bithermal Caloric Tests,indicating improved physiological function.Improvements in psychological well-being were also observed,with the Intervention Group exhibiting significantly lower HADS scores.Conclusion VR-based adaptive vestibular rehabilitation is effective in alleviating vertigo symptoms,enhancing balance function,and improving psychological well-being.The intervention also promotes the physiological recovery of semicircular canal function,demonstrating superior clinical efficacy compared to traditional rehabilitation methods. 展开更多
关键词 vertigo vestibular rehabilitation virtual reality damage to semicircular canals
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Antiradiation effects of ginseng polysaccharide and its application prospects in future food 认领 引用
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作者 Ming Jiang Dan Xiao +4 位作者 Xin Li Yukun Ma Yueming Lin Yu Jiao Hui Li 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第5期2039-2051,共13页
Panax ginseng,a foundational herb in traditional East Asian medicine,has been extensively studied for its therapeutic and nutritional properties.Among its bioactive constituents,ginseng polysaccharides(GPs)stand out f... Panax ginseng,a foundational herb in traditional East Asian medicine,has been extensively studied for its therapeutic and nutritional properties.Among its bioactive constituents,ginseng polysaccharides(GPs)stand out for their potent antioxidant,anti-inflammatory,and immunomodulatory effects.These polysaccharides,primarily composed of monosaccharides such as glucose,galactose(Gal),and arabinose(Ara),demonstrate promising potential in alleviating oxidative stress and immune suppression.With increasing exposure to ionizing radiation from medical and industrial sources,the demand for effective radioprotective agents has grown.Ionizing radiation induces DNA damage and excessive reactive oxygen species(ROS)production,resulting in oxidative stress and immune dysfunction.Research suggests that GPs mitigate radiation-induced cellular damage by enhancing antioxidant enzyme activity,suppressing inflammatory cytokines,and regulating immune responses.Despite these encouraging findings,further investigations are needed to elucidate their mechanisms of action and optimize their clinical applications.This review provides a comprehensive analysis of the composition,biological activities,and radioprotective mechanisms of GPs,highlighting their potential as functional agents for safeguarding human health against radiation-induced damage. 展开更多
关键词 Antiradiation Ginseng polysaccharide Future food
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Surface electromyography signal characteristics of lower limb muscles in children with unilateral developmental dysplasia of the hip 认领 引用
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作者 Xin Li Sheng-Hong Ma +3 位作者 Hao-Li Gong Jie Wen Fan-Ling Li Sheng Xiao 《World Journal of Orthopedics》 2026年第3期71-80,共10页
BACKGROUND Closed reduction and Salter osteotomy are commonly used to treat children with developmental dysplasia of the hip(DDH).However,it remains unclear whether the muscle activity of the lower extremities returns... BACKGROUND Closed reduction and Salter osteotomy are commonly used to treat children with developmental dysplasia of the hip(DDH).However,it remains unclear whether the muscle activity of the lower extremities returns to normal or shows compensation and imbalance after surgery.AIM To evaluate changes in surface electromyography(EMG)signals of the main muscles in both lower limbs of children with unilateral DDH during standing and walking after closed reduction surgery or Salter osteotomy.We also aimed to quantify the differences in bilateral muscle activation and explore the characteristics of surface EMG signals of the muscles around the hip joint and the postoperative rehabilitation effects.METHODS The retrospective analysis was conducted on 59 children with unilateral DDH who received treatment in the pediatric orthopedics department of a single tertiary grade A hospital.Twenty-eight children underwent closed reduction and 31 children underwent Salter osteotomy combined with femoral shortening and rotational correction osteotomy.Surface EMG was used to compare the average root mean square(RMS)values,coordination ratio,and the ratio of the RMS values between the affected and healthy sides in the bilateral tensor fasciae latae,rectus femoris,medial hamstring,anterior tibialis,medial gastrocnemius,and gluteus maximus muscles during standing and walking at the final follow-up.Outcomes were further evaluated using the Harris hip score and the modified Severin classification.RESULTS The average follow-up period was 51.64±34.85 months for the closed reduction group and 51.0±34.76 months for the Salter osteotomy group.The average Harris score was 95.91±1.01 in the Salter osteotomy group,which was lower than that of the closed reduction group(98.84±0.82;P<0.05).During walking,compared with the closed reduction group,the Salter osteotomy group showed significantly higher mean RMS values in the tensor fasciae latae on both the affected and healthy sides and in the rectus femoris on the affected side(P<0.05).In addition,the synergistic contraction between the rectus femoris muscle and hamstring muscles was significantly increased(P<0.05).CONCLUSION At the mid-term follow-up after surgery,the closed reduction and Salter osteotomy groups both achieved good functional scores and imaging results.However,during walking,muscle electrical activity of the tensor fasciae latae and rectus femoris on the affected side was increased in the Salter osteotomy group,suggesting that targeted postoperative rehabilitation exercises are warranted. 展开更多
关键词 Developmental hip dysplasia Closed reduction Salter osteotomy Surface electromyography Standing Walking
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Effect of RE/Zn atomic ratio on the microstructure of Mg-Zn-Gd-Y alloys during rolling process:A new composition design strategy for high-strength and high-thermal-conductivity magnesium alloy 认领 引用 被引量：1
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作者 Xin Li Hailong Shi +7 位作者 Xuejian Li Weimin Gan Chao Xu Chao Ding Sarvar Tursunbaev Nodir Turakhodjaev Xiaoshi Hu Xiaojun Wang 《Journal of Magnesium and Alloys》 SCIE EI CAS CSCD 2026年第3期157-175,共19页
The design of high-strength and high-thermal-conductivity magnesium alloy sheets is challenged by the inherent contradiction between strength and thermal conductivity,as well as the complex variables involved in the r... The design of high-strength and high-thermal-conductivity magnesium alloy sheets is challenged by the inherent contradiction between strength and thermal conductivity,as well as the complex variables involved in the rolling process.In this study,Mg-xZn-0.5Gd-0.5Y(at.%)(1/x=0.5,1.0,1.5)alloys were developed by adjusting the atomic ratio of rare earth(RE)elements to Zn.In the subsequent multi-pass hot rolling process,the influence of various factors on the microstructure and comprehensive properties of alloys with different compositions was obtained.With the decrease of RE/Zn atomic ratio,the W phase gradually dominates,which ensures the high thermal conductivity throughout the preparation process.Additionally,the thickness reduction per pass plays a decisive role in the properties of alloys by affecting the precipitates,dislocations and grains.The reheating between passes plays a coordinating role in the whole rolling process through the twin-induced static recrystallization mechanism.The findings indicate that leveraging the advantages of large thickness reduction per pass and effectively coordinating strain accumulation is a viable strategy for progressively enhancing the strength of highthermal-conductivity magnesium alloys,ultimately leading to superior comprehensive performance.This study provides systematic research results for the composition design and process optimization of high-strength and high-thermal-conductivity magnesium alloy rolled sheets,which is helpful to promote the performance breakthrough and application expansion in this field. 展开更多
关键词 Mg-Zn-Gd-Y alloy Composition design Rolling Twin W phase
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Fe-bearing clay minerals as catalysts for oxidant activation in organic pollutant degradation:ROS generation driven by Fe(Ⅱ)/Fe(Ⅲ)redox cycling 认领 引用
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作者 Mingli Jiang Weihua Xu +2 位作者 Xin Li Xiaofei Tan Wei Zhang 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第7期84-94,共11页
Fe-bearing clay minerals have garnered significant attention in environmental catalysis due to their unique Fe(Ⅱ)/Fe(Ⅲ)redox cycling and high surface area,which enable the effective activation of oxidants such as mo... Fe-bearing clay minerals have garnered significant attention in environmental catalysis due to their unique Fe(Ⅱ)/Fe(Ⅲ)redox cycling and high surface area,which enable the effective activation of oxidants such as molecular oxygen(O2),peroxymonosulfate,and other species,and the subsequent generation of reactive oxygen species(ROS).This review offers a comprehensive overview of the structural characteristics and iron coordination environments within these minerals that govern electron transfer processes from Fe(Ⅱ)to oxidant species.It further explores the mechanistic pathways that lead to the formation of superoxide,hydroxyl radicals(·OH),and singlet oxygen,detailing the chemical reactions involved.Additionally,the influence of various co-substrates and chelating agents,such as humic acids and ethylenediaminetetraacetic acid(EDTA),on the enhancement of redox processes and ROS generation is discussed,focusing on their roles in modulating reaction kinetics and improving catalytic efficiency.Furthermore,the review highlights the recent advancements in applying Fe-bearing clay minerals for the degradation of persistent organic pollutants,including dyes,pharmaceuticals,and pesticides,in both aqueous and soil environments.The potential for optimizing these mineral-based catalytic systems by tailoring their composition or creating hybrid materials is also explored to develop more efficient and scalable solutions for environmental remediation.This review outlines future research directions,emphasizing the integration of fundamental mechanistic insights with practical applications for pollutant degradation. 展开更多
关键词 Fe-bearing clay minerals Fe(II) Fe(III)redox cycle Synergistic additives Molecular oxygen activation Persistent organic pollutants
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Recent Advances in Piezocatalysis and Piezo-Photocatalysis in Energy and Environment:Materials,Design,and Applications 认领 引用
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作者 Yue Zhou Caihua Liu +3 位作者 Xin Li Peng Zhan Xing Xu Xiaoming Peng 《Rare Metals》 SCIE EI CAS CSCD 2026年第4期91-121,共31页
Piezocatalytic technology utilizes mechanical strain or stress-induced piezoelectric phenomena to produce robust internal electric fields,markedly improving the separation efficiency of e--h+ pairs.This method h... Piezocatalytic technology utilizes mechanical strain or stress-induced piezoelectric phenomena to produce robust internal electric fields,markedly improving the separation efficiency of e--h+ pairs.This method has emerged as a focal point in catalysis by removing reliance on conventional light or electrical energy via its mechanical-to-chemical energy conversion mechanism.Conventional piezoelectric materials(e.g.,BaTiO3 and ZnO)employ mechanically stress-induced piezoelectric phenomena to produce alternating intrinsic electric fields,which are essential for effective carrier separation and migration.Recent years have seen substantial advancements in the development of innovative piezocatalytic materials,such as transition metal chalcogenides,bismuth-based piezo-materials,metal-organic framework-based piezo-materials,and nonmetal-based piezo-materials.Researchers have enhanced the coupling mechanism between piezoelectric response and catalytic activity using tactics such as heterostructure building and defect engineering.This review thoroughly evaluates recent developments in piezocatalysis and photocatalysis,assesses the piezoelectric properties of diverse materials,and investigates optimization techniques.Mechanistic investigations elucidate the practical applications and underlying mechanisms of these technologies in environmental remediation and energy conversion,encompassing water purification,water splitting,and N2fixation and CO2 reduction.The report finishes by delineating problems in piezocatalysis and photocatalysis while proposing avenues for future research. 展开更多
关键词 environmental remediation piezo‑photocatalysis piezocatalysis piezoelectric effect piezoelectric material
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Construction of stabilizing solid electrolyte interphase with rapid Na+ transport kinetics via flame retardant for safe and high-performance sodium-ion batteries 认领 引用
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作者 Yan Meng Yuanheng Wang +6 位作者 Qingjiang Liu Xingyu Chen Hongji Pan Jinghao Zhao Lin Han Xin Li Jia-Yan Liang 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第5期673-678,共6页
The unstable solid electrolyte interphase(SEI)characterized by sluggish ion transport kinetics and consecutive side reactions poses a major challenge to the commercialization of sodium-ion batteries(SIBs).Here,ethoxy(... The unstable solid electrolyte interphase(SEI)characterized by sluggish ion transport kinetics and consecutive side reactions poses a major challenge to the commercialization of sodium-ion batteries(SIBs).Here,ethoxy(pentafluoro)cyclotriphosphazene(PFPN)as a multifunctional electrolyte additive is reported to construct stable and highly ion-conductive SEI.PFPN decomposes preferentially to form the Na F,Na3N-rich SEI with fast Na+migration kinetics due to its low lowest unoccupied molecular orbital energy and strong adsorption on hard carbon(HC)anode.Meanwhile,the incorporation of PFPN effectively suppresses exothermic reactions at the electrode/electrolyte interface,thereby reducing the risk of thermal runaway.As expected,the HC||Na cell with PFPN additive demonstrates homogeneous sodium deposition on HC anode and delivers a high reversible capacity of 248.5 m Ah/g with negligible capacity decay after 1000 cycles at 0.1 A/g.The Na Ni0.33Fe0.33Mn0.33O2(NFM)||HC full cell also yields enhanced cycling stability under-20℃.This study proposes a simple and effective SEI regulation strategy for highperformance and safe SIBs. 展开更多
关键词 Sodium-ion battery Flame-retardant additive Solid electrolyte interface Rapid Na+transport Thermal runaway
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Carnosic acid ameliorates alcohol-induced liver injury in animal models:experimental verification and molecular mechanism prediction 认领 引用
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作者 Xu Wang Yanqiu Xia +4 位作者 Xin Li Qi Tang Jing Liu Pin Lü Yan Zhang 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第3期1013-1026,共14页
Alcoholic liver disease(ALD),a pervasive global health concern,involves multifaceted pathological mechanisms including oxidative stress,lipid dysregulation and inflammatory responses,yet lacks effective multi-target t... Alcoholic liver disease(ALD),a pervasive global health concern,involves multifaceted pathological mechanisms including oxidative stress,lipid dysregulation and inflammatory responses,yet lacks effective multi-target therapies.Carnosic acid(CA),a natural diterpenoid with extensively characterized antioxidant and anti-inflammatory properties,remains underexplored for its systemic therapeutic potential in ALD.This study aimed to comprehensively investigate CA's hepatoprotective efficacy and molecular mechanisms against ALD.Results demonstrated that CA significantly reduced serum total cholesterol,triglycerides,and transaminase levels in ALD mice,concurrently alleviating alcohol-induced histopathological damage.Network pharmacology identified 36 potential targets,with 10 core targets predominantly enriched in lipid metabolism,PPAR signaling and inflammatory response.Molecular docking revealed superior binding affinities of CA to core targets compared to silibinin,a reference hepatoprotectant.RT-qPCR validation further confirmed CA's regulatory effects on apoptosis-related TP53/BCL2 axis,TNF-mediated inflammatory pathways and cytochrome P450(CYP450) metabolic genes.Through a tripartite strategy integrating phenotypic validation,mechanistic prediction,and experimental confirmation,this study elucidates CA's multi-target therapeutic actions against ALD via coordinated modulation of lipid homeostasis,oxidative stress and inflammatory pathways,providing the groundwork for future mechanism exploration. 展开更多
关键词 Carnosic acid Alcoholic liver injury Oxidative stress Inflammation Lipid metabolism
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Rational construction of MXene-derived TiO2/CoNiO2 dual-site S-scheme heterojunction for boosting C-C coupling toward efficient photocatalytic CO2-to-C2H4 conversion 认领 引用
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作者 Yongsheng Hu Shiji Du +8 位作者 Jihui Lang Huilian liu Xuefei Li Qi Zhang Ming Lu Xin Li Binrong Li Maobin Wei LiLi Yang 《Chinese Journal of Catalysis》 SCIE EI CAS CSCD 2026年第2期227-245,共19页
The CO2 photoreduction reaction(CO2RR)into C2H4 represents a highly promising technology for converting greenhouse gases into value-added chemicals.However,this technology faces challenges such as a high e... The CO2 photoreduction reaction(CO2RR)into C2H4 represents a highly promising technology for converting greenhouse gases into value-added chemicals.However,this technology faces challenges such as a high energy barrier in the C–C coupling process and a slow electron supply efficiency.In this study,we constructed Ti3C2 MXene-derived TiO2/CoNiO2 S-scheme heterojunction(MTC-X)by a simple in-situ growth process.The Co–Ni dual-site provided the structural foundation for C–C coupling,effectively reducing the energy barrier of the *CO–*COH intermediate coupling step.Meanwhile,the S-scheme heterojunction ensured the rapid supply of electrons and protons during the CO2RR,thereby enabling the efficient conversion of CO2 to C2H4.Notably,the MTC-2 sample exhibited the C2H4 production rate of 25.2μmol/(g·h),which was 23 times higher than that of the pure CoNiO2.In summary,by combining in-situ X-ray photoelectron spectroscopy,in-situ Kelvin probe force microscopy,femtosecond transient absorption spectroscopy and difference charge density calculation,confirmed the formation of the TiO2/CoNiO2 S-scheme heterojunction.Further,by photoelectrochemical tests,in-situ Fourier transform infrared spectroscopy,Gibbs free-energy calculations,elucidated the mechanism by which the Co–Ni dual-site structure and S-scheme heterojunction synergistically enhance the C–C coupling kinetic process.This provides new experimental reference and theoretical basis for the selective conversion of CO2 to C2H4. 展开更多
关键词 CO2photoreduction CoNiO2 Ti3C2MXene S-scheme heterojunction
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Untargeted metabolomic reveals changes in serum metabolism in peanut allergic mice treated by raw and roasted peanuts 认领 引用
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作者 Ying Zhang Jie Zhang +4 位作者 Xin Li Anshu Yang Ping Tong Zhihua Wu Hongbing Chen 《Food Science and Human Wellness》 SCIE CAS CSCD 2026年第4期1811-1822,共12页
Peanut allergy(PA),which affects an increasing proportion of people,is gaining increasing interests.Clarification of the mechanism underlying PA may aid in the identification of novel biomarkers and strategies for cli... Peanut allergy(PA),which affects an increasing proportion of people,is gaining increasing interests.Clarification of the mechanism underlying PA may aid in the identification of novel biomarkers and strategies for clinical intervention in allergic patients.In this study,raw peanut protein(Raw),roasted peanut protein(Roast),high-molecular-weight protein aggregation from Roast(OH),and the remaining components excluding OH from roasted peanut(OL)were administrated via intraperitoneal injection to challenge BALB/c mice.The allergic response was assessed,and the levels of peanut-specific immunoglobulin E,mouse mast cell protease-I,and T-lymphocyte subsets and secreted cytokines were detected.Then,serum untargeted metabolomics was investigated.Results show that Raw induced robust anaphylaxis in mice and up-or down-regulated 269 serum metabolites that mainly affected amino acid metabolism,including tryptophan metabolism,and induced disruption of tricarboxylic acid(TCA)cycle pathway in serum.Roast,OH and OL induced mild anaphylaxis in mice and mainly affected the glycerophospholipid metabolism in serum.Compared with Tris,OH upregulated the glycerophospholipid metabolism pathway in mouse serum,whereas Roast and OL showed the reversed effect.Mice in the Roast,OL,and OH groups all showed upregulated glycerophospholipid metabolism in serum compared with those in the Raw group.Meanwhile,different components of roasted peanut caused various changes in pathways when compared with each other.Compared with mice in the Roast group,those in the OL group displayed downregulated tryptophan and tyrosine metabolism,and those in the OH group showed upregulated glycerophospholipid metabolism and downregulated TCA cycle.The differences in serum metabolic profiles in mice implied that the processing form of allergen that patients are sensitized to and the severity of allergy should be considered in the analysis of serum biomarkers. 展开更多
关键词 Raw peanut Roasted peanut Allergenicity Serum metabolomics
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F-Mediated Precise Control Over Amorphous/Crystalline Fe/Ni-Based Phosphides Heterostructure for Efficient Oxygen Evolution Reaction 认领 引用
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作者 Haoran Li Xin Li +1 位作者 Qilin Gu Shiyou Zheng 《Rare Metals》 SCIE EI CAS CSCD 2026年第2期618-632,共15页
Transition metal-based amorphous/crystalline(a/c)heterostructured catalysts have garnered significant attention due to their exceptional activity,stability,and cost-effectiveness.However,the precise synergistic regula... Transition metal-based amorphous/crystalline(a/c)heterostructured catalysts have garnered significant attention due to their exceptional activity,stability,and cost-effectiveness.However,the precise synergistic regulation of interfacial composition and phase states remains challenging.Herein,we propose an innovative strategy for the controllable synthesis of a/c heterostructures using MIL-100(Mn)template.By leveraging the intrinsic coordination disparity between Ni2+and Fe3+to drive phase separation,combined with F-mediated ion exchange-phosphidation synergy,we successfully constructed an amorphous FePx/crystalline Ni2P heterostructure(a-(F,Fe)Px/Ni2P)with precise compositional control.Systematic investigations reveal that F-not only enhances metal ion exchange through complex stabilization but also induces amorphous/crystalline phase separation via electronic modulation.Meanwhile,a deep reconstruction process occurs under high voltage,transforming the catalyst into active F-Fe/NiOOH species,which further enhances the catalytic activity and durability.Benefiting from the synergistic effects of heterointerface electronic coupling and deep reconstruction,the as-prepared a-(F,Fe)Px/Ni2P catalyst exhibits exceptional oxygen evolution reaction(OER)performance in 1 M KOH,delivering an ultralow overpotential of 278 mV at 30 mA cm-2 and maintaining excellent stability over 100 h with negligible degradation.This work establishes a novel“coordination difference-driven,fluorine-mediated”interface engineering strategy,offering valuable insights for the rational design of high-performance heterostructured electrocatalysts. 展开更多
关键词 amorphous/crystalline heterostructure fluorine ion exchange MIL-100(Mn) oxygen evolution reaction(OER)
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Yin Yang 1-associated protein 1:Clinical significance and underlying functional mechanisms in gastric cancer 认领 引用
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作者 Ying-Chao Gu Xin Li +6 位作者 Yuan-Jun Zhao Tao Wu Cheng-Guo Zhou Wen-Liang Hu Zhi-Wei Fu Jian-Hao Huang Zi-Yang Ren 《World Journal of Gastroenterology》 SCIE CAS 2026年第21期111-122,共12页
BACKGROUND Gastric adenocarcinoma remains a lethal malignancy with limited prognostic biomarkers and therapeutic targets.Yin Yang 1-associated protein 1(YY1AP1)is a regulatory partner of Yin Yang 1,which has emerged a... BACKGROUND Gastric adenocarcinoma remains a lethal malignancy with limited prognostic biomarkers and therapeutic targets.Yin Yang 1-associated protein 1(YY1AP1)is a regulatory partner of Yin Yang 1,which has emerged as a protein of interest in the context of various biological processes and diseases.This study aimed to investigate the role of YY1AP1 in gastric adenocarcinoma.AIM To investigate the clinical significance and functional role of YY1AP1 in gastric adenocarcinoma and evaluate its potential as an independent prognostic biomarker.METHODS A total of 118 paraffin-embedded and 29 fresh gastric adenocarcinoma samples were analyzed.Immunohistochemistry was used to assess YY1AP1 expression and categorize samples into YY1AP1 high-expression group and YY1AP1 lowexpression group.Reverse transcription-quantitative polymerase chain reaction was performed on fresh samples to measure mRNA levels.Online datasets were used to independently validate prognostic value.MKN45 cells were subjected to YY1AP1 overexpression and knockdown;analyzed for p21,c-myc,and snail;and assessed for proliferation and migration.RESULTS YY1AP1 was upregulated in tumor tissues.High YY1AP1 expression was correlated with decreased p21 levels and increased c-myc and snail levels.In vitro,YY1AP1 overexpression in MKN45 cells resulted in reduced p21 expression and enhanced c-myc and snail expression,concomitant with increased cell proliferation and migration.Conversely,YY1AP1 knockdown exhibited the opposite effects.Clinically,elevated YY1AP1 levels signify poor prognosis in our cohort and online dataset.CONCLUSION YY1AP1 significantly influences the pathogenesis of gastric adenocarcinoma by modulating key cancer-related pathways.This study provides the first comprehensive analysis of YY1AP1 as an independent prognostic factor in gastric cancer.The expression of YY1AP1 is correlated with aggressive tumor behavior,highlighting its potential as a prognostic biomarker and a target for therapeutic intervention. 展开更多
关键词 Yin Yang 1-associated protein 1 Gastric adenocarcinoma Tumor proliferation Oncogene Prognostic biomarker
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Machine-learning models integrating preoperative clinical factors and circulating tumor DNA features predict lymph node metastasis in esophageal carcinoma 认领 引用
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作者 Ren-Tong Gu Xin Li +3 位作者 Wen Cheng Xiao-Wei Wang Hai Jin Tao Liu 《World Journal of Gastrointestinal Oncology》 SCIE 2026年第6期202-215,共14页
BACKGROUND Accurate assessment of lymph node metastasis(LNM)is important in patients with esophageal cancer(EC).AIM To construct machine learning(ML)models using routine clinical data to predict LNM in patients with E... BACKGROUND Accurate assessment of lymph node metastasis(LNM)is important in patients with esophageal cancer(EC).AIM To construct machine learning(ML)models using routine clinical data to predict LNM in patients with EC,exploring predictive capacity after integrating circulating tumor DNA(ctDNA)features.METHODS In this retrospective study,we collected demographic information,risk factors,protein biomarkers,computed tomography(CT),endoscopic,and pathological data of 206 patients with EC.The ctDNA data were available for 57 patients.A total of 81 models were developed using different feature-selection techniques and ML algorithms.A total of 79(38.3%)patients had pathologically confirmed LNM.RESULTS The different ML models demonstrated good predictive performance,with a median area under the curve(AUC)of 0.767(interquartile range:0.679,0.828)and median F1 score of 0.715(interquartile range:0.672,0.772).The variables were selected through univariate and multivariate logistic analyses and the best model was constructed using the random forest algorithm.It incorporated tumor length,location,CT results,depth of tumor invasion,and number of aberrant protein biomarkers.It demonstrated an AUC of 0.79(95%CI:0.65-0.93)and accuracy of 82.26%(95%CI:70.47%-90.80%),which were superior to the CT results.Incorporating ctDNA features yielded modest improvements in AUC(9.0%)and F1 score(14.3%);however,these gains were not statistically significant.CONCLUSION Combining ctDNA features with preoperative clinical factors and CT results can enhance the predictive ability of LNM models in patients with EC. 展开更多
关键词 Lymph node metastasis Computed tomography Circulating tumor DNA Variant allele frequency Esophageal cancer
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