Precise control over organic reaction dynamic requires in-situ insight into temperature and concentration variations.However,conventional detection strategies,often relying on off-line or decoupled methods,suffer from...Precise control over organic reaction dynamic requires in-situ insight into temperature and concentration variations.However,conventional detection strategies,often relying on off-line or decoupled methods,suffer from delayed responses and poor temporal synchronization.Herein,we propose a bifunctional single-fiber sensor based on Ge5As25Se30Te40 chalcogenide glass,which seamlessly integrates fiber evanescent wave spectroscopy for chemical fingerprinting identification with a thermoresistive effect for thermal sensing.It exhibits exceptional performance with a rapid temperature response(~2.6 s)and a high temperature sensitivity(jTCRj~4.07%K-1).Validated through the in-situ monitoring of ethyl butyrate synthesis,the single-fiber sensor effectively tracked reaction evolution and thermal distinctness,providing reliable guidance for process optimization and control.With its label-free detection,structural simplicity,and high sensitivity,this proposed strategy represents a robust process analytical technology tool for monitoring complex organic reactions.展开更多
Improvements to body-surface physiological monitoring ability including real-time,accuracy and integration,are essential to meet the expansive demands for personal healthcare.As part of this,simultaneous monitoring of...Improvements to body-surface physiological monitoring ability including real-time,accuracy and integration,are essential to meet the expansive demands for personal healthcare.As part of this,simultaneous monitoring of sweat metabolites and body temperature offers an exciting path to maximizing diagnostic precision and minimizing morbidity rates.Herein,we report a high-performance biomarker-temperature sensor made of a single As3Se5Te2chalcogenide glass fiber to monitor physiology evolution on body-surface.The sensor integrates efficient thermal resistance and fiber evanescent wave effects,permitting the independent sensing of temperature and biomarkers with an ultrahigh temperature coefficient of resistance(−5.84%K–1),rapid temperature response(0.3 s)and excellent IR sensing sensitivity.Moreover,by attaching a fiber to the wrist,we demonstrate simultaneous observation of both sweat metabolite(urea and lactate)and temperature changes during exercise.This illuminating sensing method will provide crucial capabilities in physiological monitoring and pave the way for advanced personalized diagnostic.展开更多
To the Editor:Ankylosing spondylitis(AS)is a chronic inflammatory disease that causes bony fusion of spine and sacroiliac joints,resulting in restricted spinal movement and deformity.In China,the prevalence of AS is a...To the Editor:Ankylosing spondylitis(AS)is a chronic inflammatory disease that causes bony fusion of spine and sacroiliac joints,resulting in restricted spinal movement and deformity.In China,the prevalence of AS is about 0.29%with a male to female ratio of approximately 3:1,and most cases occur in the adolescent period.[1]The misdiagnosis rate of AS patients in China is>50%.展开更多
To the Editor:Systemic lupus erythematosus(SLE)is an autoimmune disease characterized by the production of various autoantibodies.Disease prevalence is 20 to 70 per 100,000 among adults,and 1.89 to 25.7 per 100,000 am...To the Editor:Systemic lupus erythematosus(SLE)is an autoimmune disease characterized by the production of various autoantibodies.Disease prevalence is 20 to 70 per 100,000 among adults,and 1.89 to 25.7 per 100,000 among children.[1,2]The pathogenesis of SLE is associated with immune disorders,especially involving the activation of B and T cells,which can lead to abnormal antibodies with nuclear and cytosolic antigens from apoptotic cells of the immune complexes(ICs)removing the damaged cells,and excessive activation of the complement system,thus causing damage to target organs,such as the kidneys and lungs.展开更多
基金“Pioneer”and“Leading Goose”R&D Program of Zhejiang(2025C01166)Natural Science Foundation of Zhejiang Province(LY23F050006,LY23E020006)+3 种基金Natural Science Foundation of Ningbo Municipality(2024J460,2024J225)National Key Research and Development Program of China(2024YFB4608100)Fundamental Research Funds for the Provincial Universities of ZhejiangK.C.Wong Magna Fund in Ningbo University。
摘要Precise control over organic reaction dynamic requires in-situ insight into temperature and concentration variations.However,conventional detection strategies,often relying on off-line or decoupled methods,suffer from delayed responses and poor temporal synchronization.Herein,we propose a bifunctional single-fiber sensor based on Ge5As25Se30Te40 chalcogenide glass,which seamlessly integrates fiber evanescent wave spectroscopy for chemical fingerprinting identification with a thermoresistive effect for thermal sensing.It exhibits exceptional performance with a rapid temperature response(~2.6 s)and a high temperature sensitivity(jTCRj~4.07%K-1).Validated through the in-situ monitoring of ethyl butyrate synthesis,the single-fiber sensor effectively tracked reaction evolution and thermal distinctness,providing reliable guidance for process optimization and control.With its label-free detection,structural simplicity,and high sensitivity,this proposed strategy represents a robust process analytical technology tool for monitoring complex organic reactions.
基金supported by the“Pioneer”and“Leading Goose”R&D Program of Zhejiang(Grant No.2025C01166)National Natural Science Foundation of China(Grant Nos.62105168,62122039)+2 种基金Zhejiang Provincial Natural Science Foundation of China(Grant No.LY23F050006)Ningbo Natural Science Foundation(Grant No.2024J460)sponsored by K.C.Wong Magna Fund in Ningbo University.
摘要Improvements to body-surface physiological monitoring ability including real-time,accuracy and integration,are essential to meet the expansive demands for personal healthcare.As part of this,simultaneous monitoring of sweat metabolites and body temperature offers an exciting path to maximizing diagnostic precision and minimizing morbidity rates.Herein,we report a high-performance biomarker-temperature sensor made of a single As3Se5Te2chalcogenide glass fiber to monitor physiology evolution on body-surface.The sensor integrates efficient thermal resistance and fiber evanescent wave effects,permitting the independent sensing of temperature and biomarkers with an ultrahigh temperature coefficient of resistance(−5.84%K–1),rapid temperature response(0.3 s)and excellent IR sensing sensitivity.Moreover,by attaching a fiber to the wrist,we demonstrate simultaneous observation of both sweat metabolite(urea and lactate)and temperature changes during exercise.This illuminating sensing method will provide crucial capabilities in physiological monitoring and pave the way for advanced personalized diagnostic.
摘要To the Editor:Ankylosing spondylitis(AS)is a chronic inflammatory disease that causes bony fusion of spine and sacroiliac joints,resulting in restricted spinal movement and deformity.In China,the prevalence of AS is about 0.29%with a male to female ratio of approximately 3:1,and most cases occur in the adolescent period.[1]The misdiagnosis rate of AS patients in China is>50%.
摘要To the Editor:Systemic lupus erythematosus(SLE)is an autoimmune disease characterized by the production of various autoantibodies.Disease prevalence is 20 to 70 per 100,000 among adults,and 1.89 to 25.7 per 100,000 among children.[1,2]The pathogenesis of SLE is associated with immune disorders,especially involving the activation of B and T cells,which can lead to abnormal antibodies with nuclear and cytosolic antigens from apoptotic cells of the immune complexes(ICs)removing the damaged cells,and excessive activation of the complement system,thus causing damage to target organs,such as the kidneys and lungs.