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Endothelial GATAD1 Exacerbates Blood-brain Barrier Dysfunction in Ischemic Stroke through Caveolae-mediated Transcytosis 认领 引用
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作者 Lizhen Fan Hui Liu +8 位作者 Shanshan Li Lingling Li Zhi Zhang Pinyi Liu Haiyan Yang Shengnan Xia Xiang Cao Chun Wang Yun Xu 《Neuroscience Bulletin》 SCIE CAS CSCD 2026年第3期559-575,共17页
Blood-brain barrier(BBB)dysfunction represents a critical pathological manifestation in exacerbating ischemic stroke,contributing to neuronal death,edema formation,and unfavorable clinical outcomes.GATA zinc finger do... Blood-brain barrier(BBB)dysfunction represents a critical pathological manifestation in exacerbating ischemic stroke,contributing to neuronal death,edema formation,and unfavorable clinical outcomes.GATA zinc finger domain-containing 1(GATAD1)is recognized as a critical transcription factor in cardiac development and cardiovascular disease.However,the role of GATAD1 in regulating BBB function and ischemic stroke remains elusive.Here,we found that GATAD1 was upregulated in cerebral endothelial cells(ECs)following ischemic stroke in mice.EC-specific Gatad1 deficiency demonstrated remarkable neuroprotection,manifested by reduced infarct volumes,ameliorated BBB dysfunction,and improved neurological outcomes following experimental stroke.Mechanistic investigations revealed that GATAD1 was involved in regulating CD36 expression,thereby modulating caveolae-mediated transcytosis in cerebral ECs.These findings established GATAD1 as a novel regulator of BBB permeability and a potential therapeutic target for ischemic stroke intervention. 展开更多
关键词 GATAD1 Blood-brain barrier Transcytosis Ischemic stroke
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Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials 认领 引用 被引量：10
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作者 Siyi Xu Junqiu Jia +2 位作者 Rui Mao Xiang Cao Yun Xu 《Neural Regeneration Research》 SCIE CAS CSCD 2025年第9期2437-2453,共17页
Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health challenge.Identifying optimal ... Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health challenge.Identifying optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent priorities.Mitochondria are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell death.Mitophagy,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these events.Recent evidence has highlighted the significant role of mitophagy in acute central nervous system injuries.In this review,we provide a comprehensive overview of the process,classification,and related mechanisms of mitophagy.We also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate mitophagy.In the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area. 展开更多
关键词 autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury
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Shionone protects cerebral ischemic injury through alleviating microglia-mediated neuroinflammation 认领 引用 被引量：1
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作者 Lushan Xu Chenggang Li +8 位作者 ChenChen Zhao Zibu Wang Zhi Zhang Xin Shu Xiang Cao Shengnan Xia Xinyu Bao Pengfei Shao Yun Xu 《Chinese Journal of Natural Medicines》 SCIE CAS CSCD 2025年第4期471-479,共9页
Microglia,the resident immune cells in the central nervous system(CNS),rapidly transition from a resting to an active state in the acute phase of ischemic brain injury.This active state mediates a pro-inflammatory res... Microglia,the resident immune cells in the central nervous system(CNS),rapidly transition from a resting to an active state in the acute phase of ischemic brain injury.This active state mediates a pro-inflammatory response that can exacerbate the injury.Targeting the pro-inflammatory response of microglia in the semi-dark band during this acute phase may effectively reduce brain injury.Shionone(SH),an active ingredient extracted from the dried roots and rhizomes of the genus Aster(Asteraceae),has been reported to regulate the inflammatory response of macrophages in sepsis-induced acute lung injury.However,its function in post-stroke neuroinflammation,particularly microglia-mediated neuroinflammation,remains uninvestigated.This study found that SH significantly inhibited lipopolysaccharide(LPS)-induced elevation of inflammatory cytokines,including interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),and inducible nitric oxide synthase(iNOS),in microglia in vitro.Furthermore,the results demonstrated that SH alleviated infarct volume and improved behavioral performance in middle cerebral artery occlusion(MCAO)mice,which may be attributed to the inhibition of the microglial inflammatory response induced by SH treatment.Mechanistically,SH potently inhibited the phosphorylation of serine-threonine protein kinase B(AKT),mammalian target of rapamycin(mTOR),and signal transducer and activator of transcription 3(STAT3).These findings suggest that SH may be a potential therapeutic agent for relieving ischemic stroke(IS)by alleviating microglia-associated neuroinflammation. 展开更多
关键词 Shionone Ischemic Stroke Neuroinflammation Microglial Activation AKT-mTOR-STAT3 Signaling Pathway
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Polymeric micelle-hydrogel composites design for biomedical applications 认领 引用 被引量：2
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作者 Hongyi Li Huiyun Wen +7 位作者 He Zhang Jin Li Xiang Cao Jiaqing Zhang Yutao Zheng Saipeng Huang Weiming Xue Xiaojun Cai 《Chinese Chemical Letters》 SCIE CAS CSCD 2025年第5期74-81,共8页
Designing advanced hydrogels with controlled mechanical properties,drug delivery manner and multifunctional properties will be beneficial for biomedical applications.However,the further development of hydrogel is limi... Designing advanced hydrogels with controlled mechanical properties,drug delivery manner and multifunctional properties will be beneficial for biomedical applications.However,the further development of hydrogel is limited due to its poor mechanical property and structural diversity.Hydrogels combined with polymeric micelles to obtain micelle-hydrogel composites have been designed for synergistic enhancement of each original properties.Incorporation polymeric micelles into hydrogel networks can not only enhance the mechanical property of hydrogel,but also expand the functionality of hydrogel.Recent advances in polymeric micelle-hydrogel composites are herein reviewed with a focus on three typical micelle incorporation methods.In this review,we will also highlight some emerging biomedical applications in developing micelle-hydrogel composite with multiple functionalities.In addition,further development and application prospects of the micelle-hydrogels composites have also been addressed. 展开更多
关键词 Polymeric micelle Hydrogel composites Incorporation methods Biomedical applications Local tumor treatment Tissue engineering
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Research on Information-Based Management Strategies for Communication Engineering Construction 认领 引用
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作者 Xiang Cao Lin Chen 《Journal of Economic Insights》 2025年第1期56-64,共9页
This study presents a comprehensive framework for intelligent management in communication engineering construction,addressing critical challenges posed by 5G/6G network evolution and New Infrastructure policies.Center... This study presents a comprehensive framework for intelligent management in communication engineering construction,addressing critical challenges posed by 5G/6G network evolution and New Infrastructure policies.Centered on a digital twin-driven architecture,the proposed system integrates space-air-ground monitoring,AIoT-enabled self-organizing networks,and SDN-based elastic resource scheduling to achieve end-to-end lifecycle optimization.A four-dimensional hierarchical model(Perception-Network-Platform-Application)is developed to enhance cross-domain collaboration through intelligent sensing,hybrid networking,and augmented reality decision support.Key innovations include:(1)a dynamic Bayesian network for real-time risk prediction,reducing response time by 40%;(2)a reinforcement learning-driven resource allocation mechanism,improving equipment coordination efficiency by 30%;and(3)a blockchain-enhanced industrial metaverse platform,resolving ecosystem fragmentation via smart contracts and standardized protocols.Empirical validation demonstrates significant gains in project controllability and cost-effectiveness.Future directions extend the framework to 6G reconfigurable surfaces,quantum-secured command systems,and embodied AI construction robots,offering transformative pathways for autonomous and adaptive engineering ecosystems. 展开更多
关键词 Communication Engineering Digital Twin Blockchain Industrial Metaverse 6G AIoT
GM-CSF Promotes the Development of Dysfunctional Vascular Networks in Moyamoya Disease 认领 引用 被引量：3
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作者 Huiqin Li Xiang Cao +8 位作者 Xinya Gu Mengqi Dong Lili Huang Chenglu Mao Shengnan Xia Haiyan Yang Xinyu Bao Yongbo Yang Yun Xu 《Neuroscience Bulletin》 SCIE CAS CSCD 2024年第4期451-465,共15页
Moyamoya disease(MMD)is a chronic occlusive cerebrovascular disease with the development of a network of abnormal vessels.Immune inflammation is associated with the occurrence and development of MMD.However,the mechan... Moyamoya disease(MMD)is a chronic occlusive cerebrovascular disease with the development of a network of abnormal vessels.Immune inflammation is associated with the occurrence and development of MMD.However,the mechanisms underlying the formation of the abnormal vascular network remain unclear.Twenty-eight patients with MMD,26 ischemic stroke patients,and 26 unrelated healthy volunteers were enrolled in this study The data showed that the levels of granulocyte-macrophage colony-stimulating factor(GM-CSF)were higher in MMD patients than in healthy controls(P<0.01),and GM-CSF was mainly from Th1 and Th17 cells in MMD.We found that increased GM-CSF drove monocytes to secrete a series of cytokines associated with angiogenesis,inflammation,and chemotaxis.In summary,our findings demonstrate for the first time the important involvement of GM-CSF in MMD and that GM-CSF is an important factor in the formation of abnormal vascular networks in MMD. 展开更多
关键词 Moyamoya disease Vascular endothelial cells GM-CSF VEGF
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Effect of advanced paternal age on reproductive outcomes in IVF cycles of non-male-factor infertility: a retrospective cohort study 认领 引用 被引量：1
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作者 Xin-Mei Lu Yu-Bing Liu +6 位作者 Dou-Dou Zhang Xiang Cao Tian-Cheng Zhang Miao Liu Hui-Juan Shi Xi Dong Su-Ying Liu 《Asian Journal of Andrology》 SCIE CAS CSCD 2023年第2期245-251,共7页
Advanced paternal age has been overlooked,and its effect on fertility remains controversial.Previous studies have focused mainly on intracytoplasmic sperm injection(ICSI)cycles in men with oligozoospermia.However,few ... Advanced paternal age has been overlooked,and its effect on fertility remains controversial.Previous studies have focused mainly on intracytoplasmic sperm injection(ICSI)cycles in men with oligozoospermia.However,few studies have reported on men with semen parameters within reference ranges.Therefore,we conducted a retrospective cohort study analyzing the reproductive outcomes of couples with non-male-factor infertility undergoing in vitro fertilization(IVF)cycles.In total,381 cycles included were subgrouped according to paternal age(0.05).The pregnancy rate was not significantly different in the 35–39-year-old group(42.0%;P>0.05),but was significantly lower in the≥40-year-old group(26.1%;P0.05),but showed a declining trend.The miscarriage rate significantly increased in the 35–39-year-old group(44.8%)compared with that in the<35-year-old group(21.0%;P<0.05).No abnormality in newborn birth weight was found.The results indicated that paternal age over 40 years is a key risk factor that influences the assisted reproductive technology success rate even with good semen parameters,although it has no impact on embryo development. 展开更多
关键词 embryo development implantation in vitro fertilization paternal age pregnancy sperm
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Identifying nasopharyngeal carcinoma patients with metachronous metastasis sensitive to local treatment:a real-world study 认领 引用
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作者 Fanyu Peng Yizhi Ge +5 位作者 Rongrong Wang Dingdong Hu Xiang Cao Yujie Zhang Dan Zong Xia He 《Journal of Biomedical Research》 CAS CSCD 2022年第4期221-230,共10页
It is difficult for physicians to identify patients with metastatic nasopharyngeal carcinoma(NPC)who are sensitive to local treatment of metastases.Here,we aimed to establish a prognostic model for survival and indivi... It is difficult for physicians to identify patients with metastatic nasopharyngeal carcinoma(NPC)who are sensitive to local treatment of metastases.Here,we aimed to establish a prognostic model for survival and individualize treatments for patients with metastatic NPC.Data were collated from 240 NPC patients diagnosed with metachronous metastasis between 2006 and 2020 who received palliative chemotherapy with or without local treatment.Multivariable Cox regression was implemented to construct a nomogram which had a concordance index of 0.764 when predicting 1-,3-,and 5-year overall survival(OS).We then classified patients according to risk,creating low-and high-risk groups using the nomogram.Differences in OS between the two groups were significant(P<0.001).In the low-risk group,the OS for patients who received local treatment was longer than those without(P=0.009).This novel nomogram shows good performance in classifying patients according to risk and may also be a promising tool for determining who responds best to local treatment.Further validation using external center data is warranted. 展开更多
关键词 nasopharyngeal carcinoma metastasis prognostic model treatment overall survival
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Neuroprotective effects of ZL006 in Aβ1–42-treated neuronal cells 认领 引用 被引量：2
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作者 Wen-Yuan Tao Lin-Jie Yu +6 位作者 Su Jiang Xiang Cao Jian Chen Xin-Yu Bao Fei Li Yun Xu Xiao-Lei Zhu 《Neural Regeneration Research》 SCIE CAS CSCD 2020年第12期2296-2305,共10页
Amyloid beta(Aβ)-induced neurotoxicity and oxidative stress plays an important role in the pathogenesis of Alzheimer’s disease(AD).ZL006 is shown to reduce over-produced nitric oxide and oxidative stress in ischemic... Amyloid beta(Aβ)-induced neurotoxicity and oxidative stress plays an important role in the pathogenesis of Alzheimer’s disease(AD).ZL006 is shown to reduce over-produced nitric oxide and oxidative stress in ischemic stroke by interrupting the interaction of neuronal nitric oxide synthase and postsynaptic density protein 95.However,few studies are reported on the role of ZL006 in AD.To investigate whether ZL006 exerted neuroprotective effects in AD,we used Aβ1–42 to treat primary cortical neurons and N2a neuroblastoma cells as an in vitro model of AD.Cortical neurons were incubated with ZL006 or dimethyl sulfoxide for 2 hours and treated with Aβ1–42 or NH3·H2O for another 24 hours.The results of cell counting Kit-8(CCK-8)assay and calcein-acetoxymethylester/propidium iodide staining showed that ZL006 pretreatment rescued the neuronal death induced by Aβ1–42.Fluorescence and western blot assay were used to detect oxidative stress and apoptosis-related proteins in each group of cells.Results showed that ZL006 pretreatment decreased neuronal apoptosis and oxidative stress induced by Aβ1–42.The results of CCK8 assay showed that inhibition of Akt or NF-E2-related factor 2(Nrf2)in cortical neurons abolished the protective effects of ZL006.Moreover,similar results were also observed in N2a neuroblastoma cells.ZL006 inhibited N2a cell death and oxidative stress induced by Aβ1–42,while inhibition of Akt or Nrf2 abolished the protective effect of ZL006.These results demonstrated that ZL006 reduced Aβ1–42-induced neuronal damage and oxidative stress,and the mechanisms might be associated with the activation of Akt/Nrf2/heme oxygenase-1 signaling pathways. 展开更多
关键词 Akt Alzheimer’s disease amyloid-beta apoptosis heme oxygenase-1 neurotoxicity Nrf2 oxidative stress treatment ZL006
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Impact of the Belt and Road Initiative on environmental quality in countries along the routes 认领 引用
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作者 Xiang Cao Congbo Teng Jijun Zhang 《Chinese Journal of Population,Resources and Environment》 2021年第4期344-351,共8页
China has adhered to the concept of green development since the introduction of the Belt and Road Initiative in 2013.However,as the initiative continues to advance,speculations have been raised on the possibility of i... China has adhered to the concept of green development since the introduction of the Belt and Road Initiative in 2013.However,as the initiative continues to advance,speculations have been raised on the possibility of its reduction of the environmental quality of the countries along the routes.So,has the seven-year-old Belt and Road Initiative reduced the environmental quality of these countries and how does it affect the environmental quality?To address these issues,this study conducted a quasi-natural experiment,based on the WDI 2005-2017 data,the human development index database of the World Bank and the OECD(Organization for Economic Cooperation and Development)database.A country-year panel data was constructed using the difference-in-differences model to assess the countries along the‘area’initiative for environmental effects,and to further examine the heterogeneity and the policy effect mechanism.The main conclusions were as follows:①The Belt and Road Initiative had significantly improved the environmental quality of countries along the routes.The conclusions remained robust after the introduction of the placebo test,the use of instrumental variables to alleviate possible endogenous problems and a series of other robustness tests.②The results of heterogeneity analysis showed that the Belt and Road Initiative exerted a greater effect on the countries with lower environmental quality than those with higher quality in terms of environmental improvements.③Mechanism analysis showed that the Belt and Road Initiative improved the environmental quality of countries along the routes by promoting technological progress and strengthening environmental regulation,but it failed to significantly improve the environmental quality of these countries by promoting clean energy structure and industrial structure and increasing the scale effect.Therefore,China should continue to vigorously promote the concept of developing a green Belt and Road,expand the coverage of the green Belt and Road,improve the level of clean energy structure of the Belt and Road countries through investment and cooperation,and promote the clean transformation of their industrial structure.These findings provide empirical evidence and implications for the better promotion of the green Belt and Road Initiative,and have certain reference value for the follow-up implementation of the Belt and Road Initiative. 展开更多
关键词 Belt and Road Initiative Environmental pollution Difference-in-differences model
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地下污水处理厂污泥干化车间通风除臭系统设计 认领 引用 被引量：4
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作者 谢艺强 刘承东 +3 位作者 向操 唐宏辉 黄勇锐 叶晓春 《暖通空调》 2022年第9期54-57,28,共4页
分析了地下污水处理厂污泥干化车间臭气处理的难点和重点及应对措施,介绍了广州地下污水处理厂污泥干化车间通风除臭系统及空调系统的设计。试运行效果显示,污泥干化车间臭气浓度得到了有效控制,臭气排放水平远高于目前国内标准要求。
关键词 地下污水处理厂 污泥干化车间 通风除臭 臭气浓度 空调系统
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Analysis of two cases of patent ductus arteriosus ligation in preterm identical twins and literature review 认领 引用
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作者 Xiang Cao Xiao-Ding Chen +4 位作者 Ling Yang Ren-Wei Chen Yan Li Ze-Lai Mo Wei Xiang 《Journal of Hainan Medical University》 CAS 2020年第17期57-60,共4页
Objective:To investigate the timing and effect of surgical ligation in the treatment of patent ductus arteriosus(PDA)in preterm identical twins.Methods:Retrospective analysis was made on the treatment of 2 cases of pr... Objective:To investigate the timing and effect of surgical ligation in the treatment of patent ductus arteriosus(PDA)in preterm identical twins.Methods:Retrospective analysis was made on the treatment of 2 cases of preterm twins with hemodynamic significant PDA(hsPDA)with corresponding clinical manifestation in our neonatology department,and literatures of PDA ligation for preterm twins were retrieved.Results:These 2 cases were naturally conceived monochorionic diamniotic twins,with gestational age 30+2 weeks,birth weight was 1510g and 780g for larger twin and smaller twin,with birth weight discordance 48.3%.They both developed hsPDA with corresponding clinical manifestation,series Echocardiography showed evidence of left to right shunting and cardiac insufficiency which were left atrial and ventricular enlargement,large PDA(2.8~3.5mm),failed two courses of ibuprofen,N-terminal pro-brain natriuretic peptide level increased significantly,finally received surgical ligation with significant clinical improvement and no related complications.12 cases were found from literature search,including our 2 cases,of these,2 died,9 were cured and 1 improved significantly.Among 6 cases whose detailed information were available,4 infants were identical twins,2 unknown.Conclusions:Preterm identical twins have the same genetic basis,the possibility of PDA ligation for both the larger twin and smaller twin should be alerted if the gestaional age is small and birth weight discordance is above 30%.If preterm twins have hsPDA who may fail ibuprofen treatment,surgical ligation should be considered early,and it is safe and effective. 展开更多
关键词 Identical twins Preterm infant Patent ductus arteriosus ligation
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Falcon: A Novel Chinese Short Text Classification Method 认领 引用 被引量：1
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作者 Haiming Li Haining Huang +1 位作者 Xiang Cao Jingu Qian 《Journal of Computer and Communications》 2018年第11期216-226,共11页
For natural language processing problems, the short text classification is still a research hot topic, with obviously problem in the features sparse, high-dimensional text data and feature representation. In order to ... For natural language processing problems, the short text classification is still a research hot topic, with obviously problem in the features sparse, high-dimensional text data and feature representation. In order to express text directly, a simple but new variation which employs one-hot with low-dimension was proposed. In this paper, a Densenet-based model was proposed to short text classification. Furthermore, the feature diversity and reuse were implemented by the concat and average shuffle operation between Resnet and Densenet for enlarging short text feature selection. Finally, some benchmarks were introduced to evaluate the Falcon. From our experimental results, the Falcon method obtained significant improvements in the state-of-art models on most of them in all respects, especially in the first experiment of error rate. To sum up, the Falcon is an efficient and economical model, whilst requiring less computation to achieve high performance. 展开更多
关键词 Short Text Classification Word Vector Representation One-Hot Densenet Networks Convolutional Neural Networks
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城镇地下污水处理厂环境控制策略与设计标准简析 认领 引用
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作者 刘承东 向操 谢艺强 《暖通空调》 2022年第9期29-35,共7页
针对地下污水处理厂除臭系统和通风系统在传统设计中未能统筹考虑而导致空气环境失控的问题,通过简要分析地下污水处理厂地下空间空气环境特性、污染物排放标准、污染物初始浓度标准及臭气治理的重点和难点,结合多个地下污水处理厂工程... 针对地下污水处理厂除臭系统和通风系统在传统设计中未能统筹考虑而导致空气环境失控的问题,通过简要分析地下污水处理厂地下空间空气环境特性、污染物排放标准、污染物初始浓度标准及臭气治理的重点和难点,结合多个地下污水处理厂工程实践经验,提出了地下污水处理厂通风与除臭系统相结合的环境控制策略及设计标准。 展开更多
关键词 地下污水处理厂 环境控制 除臭系统 通风系统 离子新风 压差控制
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Artificial mesenchymal stem cell extracellular vesicles enhanced ischemic stroke treatment through targeted remodeling brain microvascular endothelial cells 认领 引用 被引量：2
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作者 Shengnan Li Wei Lv +8 位作者 Jiangna Xu Jiaqing Yin Yuqin Chen Linfeng Liu Xiang Cao Wenjing Li Zhen Li Hua Chen Hongliang Xin 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2025年第8期4248-4264,共17页
Ischemic stroke is the leading cause of disability and mortality worldwide.The blood‒brain barrier(BBB)is the first line of defense after ischemic stroke.Disruption of the BBB induced by brain microvascular endothelia... Ischemic stroke is the leading cause of disability and mortality worldwide.The blood‒brain barrier(BBB)is the first line of defense after ischemic stroke.Disruption of the BBB induced by brain microvascular endothelial cells(BMECs)dysfunction is a key event that triggers secondary damage to the central nervous system,where blood-borne fluids and immune cells penetrate the brain parenchyma,causing cerebral edema and inflammatory response and further aggravating brain damage.Here,we develop a novel artificial mesenchymal stem cell(MSC)extracellular vesicles by integrating MSC membrane proteins into liposomal bilayers,which encapsulated miR-132-3p with protective effects on BMECs.The artificial extracellular vesicles(MSCo/miR-132-3p)had low immunogenicity to reduce non-specific clearance by the mononuclear phagocytosis system(MPS)and could target ischemia Apoptosis;Ischemic stroke therapy injured BMECs.After internalization into the damaged BMECs,MSCo/miR-132-3p escaped the lysosomes via the HⅡ phase transition of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine(DOPE)and decreased cellular reactive oxygen species(ROS)and apoptosis levels by regulating the RASA1/RAS/PI3K/AKT signaling pathway.In the transient middle cerebral artery occlusion(tMCAO)models,MSCo/miR-132-3p targeted impaired brain regions(approximately 9 times the accumulation of plain liposomes at 12 h),reduced cerebral vascular disruption,protected BBB integrity,and decreased infarct volume(from 44.95% to 6.99%). 展开更多
关键词 Artificial extracellular vesicles Mesenchymal stem cell membrane proteins miR-132-3p Cerebral vascular endothelial cells Blood‒brain barrier Oxidative stress Apoptosis Ischemic stroke therapy
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Transient porous transpiration cooling using a two-phase semi-mixed model 认领 引用
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作者 Xiang CAO Yi ZHENG +2 位作者 Suchen WU Wenhao LAI Chengbin ZHANG 《Science China(Technological Sciences)》 SCIE EI CAS CSCD 2025年第8期103-114,共12页
The transient characteristics of transpiration cooling are important for hypersonic flight vehicles.This paper presents a two-dimensional transient semi-mixed model(SMM)developed to numerically analyze the two-phase f... The transient characteristics of transpiration cooling are important for hypersonic flight vehicles.This paper presents a two-dimensional transient semi-mixed model(SMM)developed to numerically analyze the two-phase flow and heat transfer performance of porous transpiration cooling during the startup process.The study investigates the transient behavior of porous transpiration cooling,including temperature and saturation evolution,as well as variations in evaporation mass.Additionally,the effects of Mach number(Ma)and porosity on transient transpiration cooling are examined and analyzed.The results reveal that the startup process of transpiration cooling progresses sequentially through three stages:an initial temperature rise(stageⅠ),a constant temperature phase(stageⅡ),and a second temperature rise(stageⅢ)for the aerodynamic thermal surface.The durations of stagesⅠandⅡare relatively short compared to the entire startup period,with the dry region moving downward until reaching an equilibrium depth in stageⅢ.At higher Ma,stage Ⅱ disappears,the inlet mass flux is insufficient for early evaporation,and the equilibrium depth of the dry-wet interface increases.Additionally,for a porous structure with higher porosity under the same driving force,the inlet mass flux increases,prolonging the duration of stage II.This,in turn,reduces both the equilibrium depth of the dry-wet interface and the overall temperature of the porous structure. 展开更多
关键词 transpiration cooling porous evaporation semi-mixed model hypersonic
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A multifunctional dihydromyricetin-loaded hydrogel for the sequential modulation of diabetic wound healing and glycemic control 认领 引用 被引量：3
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作者 Hongyi Li Huiyun Wen +8 位作者 He Zhang Xiang Cao Li Li Xiaowen Hu Yanmei Zhang Xinkun Shen Quazi T.H.Shubhra Hong Yang Xiaojun Cai 《Burns & Trauma》 SCIE CSCD 2025年第1期924-943,共20页
Background:The management of chronic diabetic wounds remains a formidable challenge in clinical practice.Persistent hyperglycemia triggers vasculopathy,neuropathy,and immune dysfunction,critically impeding wound repai... Background:The management of chronic diabetic wounds remains a formidable challenge in clinical practice.Persistent hyperglycemia triggers vasculopathy,neuropathy,and immune dysfunction,critically impeding wound repair.We developed a multifunctional hydrogel(DPFl)engineered for sequential therapeutic actions,including antibacterial,anti-inflammatory,antioxidant,pro-vascularization/epithelialization,and glycemic-regulating properties,to address these complications.Methods:DPFl hydrogels were prepared by encapsulating dihydromyricetin(DMY)into aldehyde-functionalized Pluronic F127 micelles(DMY@PF127-CHO),followed by a Schiff base reaction with amine-rich polyethyleneimine(PEl),resulting in the formation of a hydrogel for controlled drug release.The antimicrobial,antioxidant,anti-inflammatory,pro-cellular proliferative,and angiogenic properties of the hydrogels were evaluated using various techniques,including structural characterization,bacterial live/dead staining,reactive oxygen species(ROS)assays,antioxidant enzyme assays,reverse transcription-polymerase chain reaction(RT-PCR),cellular immunofluorescence staining,scratch wound healing assays,and angiogenesis assays.In vivo,the effects of the hydrogel on wound healing and glycemic control were assessed in methicillinresistant Staphylococcus aureus-infected mice with streptozotocin-induced diabetes.Results:The hydrogel exhibits exceptional injectability,bioadhesion,and self-healing properties,facilitating the controlled,sustained release of DMY,which synergistically enhances antimicrobial effects in combination with PEI.The antioxidant activity of DMY is remarkable;it effectively scavenges ROS and induces the expression of antioxidant enzymes while promoting the phenotypic switch of M1 macrophages to M2 macrophages to mitigate inflammation.Critically,DPFI also contributes to glycemic regulation,reducing hyperglycemia-associated complications and creating a microenvironment conducive to wound repair.Comprehensive in vitro and in vivo analyses corroborate the multifaceted therapeutic capabilities of DPFl,including its antibacterial activity and abilities to clear ROS,reduce inflammation,promote angiogenesis,promote epithelialization,and modulate blood glucose levels.Conclusions:DPFI represents a promising,integrative strategy for enhanced diabetic wound management,meriting further exploration for clinical application. 展开更多
关键词 Chronic diabetic wound Multifunctional hydrogel Dihydromyricetin(DMY) Sequential therapeutic modulation Glycemic control Antioxidant and anti-inflammatory effects
Do Chinese real estate stocks behave differently during bulland bear market conditions? 认领 引用
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作者 Xiang cao 《经贸实践》 2016年第6X期134-138,共5页
Stocks have been very fast growing in recent decades in most countries. Investing in the stock market is the best way to achieve ones financial goals, however, people are facing difficult choices on how to pick which ... Stocks have been very fast growing in recent decades in most countries. Investing in the stock market is the best way to achieve ones financial goals, however, people are facing difficult choices on how to pick which stocks to invest in. That's why stock portfolios should be professionally managed to provide low risk, diversified yields.The aim of this research is to examine the timing and selection processes of Chinese stocks using the TM method:(Treynor and Mazuy: 1966). This traditional, unconditional model uses a sample of 69 stocks from the real estate industry for a 10 calendar year period from January 1, 2004 to December 31, 2013. The TM model was used overall to estimate the total effectiveness of both the timing and selection processes for all 69 stock performances.The results of this study revealed that Chinese stock investors do not have the successful ability to time the market and 50 out of67 stocks, or 74.63% of the studied stocks, produced an excess asset return of no more than 0. Therefore, almost all of the stocks in the study did worse in the current bull market than in a bear market! 展开更多
关键词 CAPM stock invest
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Evaluation of an online SSVEP-BCI with fast system setup 认领 引用 被引量：1
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作者 Xiaodong Li Junlin Wang +5 位作者 Xiang Cao Yong Huang Wei Huang Feng Wan Michael Kai-Tsun To Sheng Quan Xie 《Journal of Neurorestoratology》 2024年第2期120-130,共11页
The brainecomputer interface(BCI)plays an important role in neural restoration.Current BCI systems generally require complex experimental preparation to perform well,but this time-consuming process may hinder their us... The brainecomputer interface(BCI)plays an important role in neural restoration.Current BCI systems generally require complex experimental preparation to perform well,but this time-consuming process may hinder their use in clinical applications.To explore the feasibility of simplifying the BCI system setup,a wearable BCI system based on the steady-state visual evoked potential(SSVEP)was developed and evaluated.Fifteen healthy participants were recruited to test the fast-setup system using dry and wet electrodes in a real-life scenario.In this study,the average system setup time for the dry electrode was 38.40 seconds and that for the wet electrode was 103.40 seconds,which are times appreciably shorter than those in previous BCI experiments,enabling a rapid setup of the BCI system.Although the electroencephalogram(EEG)signal quality was low in this fast-setup BCI experiment,the BCI system achieved an information transfer rate of 138.89 bits/min with an eight-channel wet electrode and an information transfer rate of 70.59 bits/min with an eight-channel dry electrode,showing that the overall performance was close to that in traditional experiments.In addition,the results suggest that the solutions of a multi-channel dry electrode or few-channel wet electrode may be suitable for the fast-setup SSEVP-BCI.This fast-setup SSVEP-BCI has the advantages of simple preparation and stable performance and is thus conducive to promoting the use of the BCI in clinical practice. 展开更多
关键词 Brain-computer interface Steady-state visual evoked potential System setup Online adaptive canonical correlation analysis
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