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Progress on Omega-3 fatty acids for the comprehensive and targeted treatment of spinal cord injury 认领 引用
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作者 Zhongze Yuan Lusen Shi +15 位作者 Xiao-Na Tao Xiangchuang Fan Han Zheng Yifan Shang Xiaoqing Zhao Fan Yang Hui Lin Peng Xiao Bo Chu Jichuan Qiu Shaohui Zong Ning Ran Xiaohong Kong Jin-Peng Sun Hengxing Zhou Shiqing Feng 《Bone Research》 SCIE CAS CSCD 2026年第1期62-81,共20页
Traumatic spinal cord injury(SCI)is a debilitating condition characterized by the impairment of neural circuits,leading to the loss of motor and sensory functions and accompanied by severe complications.Substantial re... Traumatic spinal cord injury(SCI)is a debilitating condition characterized by the impairment of neural circuits,leading to the loss of motor and sensory functions and accompanied by severe complications.Substantial research has reported the therapeutic potential of Omega-3 fatty acids for the central nervous system,particularly after traumatic SCI.Omega-3 fatty acids may contribute to improving SCI recovery through their anti-inflammatory,anti-oxidative,neurotrophic,and membrane integrity-preserving properties.These functions of Omega-3 fatty acids are primarily mediated via the activation of G protein-coupled receptor 120(GPR120),commonly known as the fish oil-specific receptor.Advancements in understanding of the molecular mechanisms of GPR120’s recognition of Omega-3 fatty acids and its downstream signaling mechanisms has significantly promoted research on the pharmacological potential of Omega-3 fatty acids and the development of highly selective and high-affinity alternatives.This review aims to provide in-depth analysis of the comprehensive therapeutic potential of Omega-3 fatty acids for SCI and its accompanying complications,and the prospects for developing novel drugs based on the recognition of Omega-3 fatty acids by GPR120. 展开更多
关键词 central nervous systemparticularly impairment neural circuitsleading spinal cord injury traumatic spinal cord injury omega fatty acids sensory functions traumatic spinal cord injury sci neural circuits
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A novel mouse model of central cord syndrome 认领 引用
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作者 Elzat Elham-Yilizati Yilihamu Xiangchuang Fan +1 位作者 Zimeng Yang Shiqing Feng 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第12期2751-2756,共6页
Patients with potential spinal stenosis are susceptible to central cord syndrome induced by blunt trauma.Suitable animal models are helpful for studying the pathogenesis and treatment of such injuries.In this study,we... Patients with potential spinal stenosis are susceptible to central cord syndrome induced by blunt trauma.Suitable animal models are helpful for studying the pathogenesis and treatment of such injuries.In this study,we established a mouse model of acute blunt traumatic spinal cord injury by compressing the C6 spinal cord with 5 and 10 g/mm~2 compression weights to simulate cervical central cord syndrome.Behavioral testing confirmed that this model exhibited the characteristics of central cord syndrome because motor function in the front paws was impaired,whereas basic motor and sensory functions of the lower extremities were retained.Hematoxylin-eosin staining showed that the diseased region of the spinal cord in this mouse model was restricted to the gray matter of the central cord,whereas the white matter was rarely affected.Magnetic resonance imaging showed a hypointense signal in the lesion after mild and severe injury.In addition,immunofluorescence staining showed that the degree of nerve tract injury in the spinal cord white matter was mild,and that there was a chronic inflammation reaction.These findings suggest that this mouse model of central cord syndrome can be used as a model for preclinical research,and that gray matter is most vulnerable to injury in central cord syndrome,leading to impaired motor function. 展开更多
关键词 animal model behavior central cord syndrome cervical spinal cord injury cervical spinal cord pathology preclinical research spinal cord spinal cord compression spinal cord injury
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