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Impact of pre-chemotherapy locomotive syndrome status on shortterm adverse outcome events in elderly lung cancer patients:A longitudinal study 认领 引用
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作者 Dan-Hua Liang Xiao-Rui Feng +2 位作者 Lan Li Ying Chen Yu-Ling Yang 《World Journal of Orthopedics》 2026年第3期104-112,共9页
BACKGROUND Despite growing recognition of locomotive syndrome(LS)in the general elderly population,research focusing on its prevalence and clinical implications among elderly lung cancer patients remains limited.Exist... BACKGROUND Despite growing recognition of locomotive syndrome(LS)in the general elderly population,research focusing on its prevalence and clinical implications among elderly lung cancer patients remains limited.Existing studies have predominantly examined nutritional,immune,or systemic functional factors influencing chemotherapy tolerance and prognosis,while musculoskeletal health-an equally critical determinant of patient outcomes-has received insufficient attention.AIM To investigate the effect of pre-chemotherapy LS status on short-term adverse outcome events among elderly lung cancer patients.METHODS This study employed convenience sampling to recruit 410 elderly lung cancer patients admitted to the Affiliated Hospital of Jiangnan University from January 2024 to June 2024.Clinical data of the patients were collected,and they were divided into the LS group and the non-LS group according to their LS status before chemotherapy.The patients were followed up for 6 months.Toxicity during chemotherapy and adverse outcomes such as death,incapacitation,and unplanned hospitalization during the follow-up period were recorded.RESULTS This study finished data collection on 386 elderly lung cancer patients.Among them,161 were diagnosed with LS before chemotherapy,while 225 were non-LS patients.After chemotherapy,the incidence of LS was significantly higher in the LS group than in the non-LS group(P<0.05).During the chemotherapy,the LS group experienced a significantly greater incidence of toxicities when compared to the non-LS group(P<0.05).The toxicity grading in the LS group was significantly higher than that in the non-LS group(P<0.05).During the follow-up period,the mortality rate of the LS group was significantly higher than that of the non-LS group(P<0.05).Moreover,patients in the LS group faced more severe incapacitation and a higher rate of unplanned hospitalizations than those in the non-LS group(P<0.05).CONCLUSION Pre-chemotherapy LS has become more prevalent among elderly lung cancer patients,and its incidence further increases after chemotherapy.Elderly lung cancer patients with pre-chemotherapy LS experience numerous and severe toxic side effects during chemotherapy.They also face a high risk of death,suffer from severe disability,and have a high rate of unplanned hospitalization during the follow-up period. 展开更多
关键词 Elderly lung cancer patients Antitumor combination chemotherapy regimens Locomotive syndrome Drug-related adverse effects Pre-chemotherapy
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