The grain refinement effect of superalloy K4169 under a low-voltage pulsed magnetic field(PMF)with different pulse frequencies and pulse voltages,at a superheat of 191℃,was investigated.The grains of the ingots are r...The grain refinement effect of superalloy K4169 under a low-voltage pulsed magnetic field(PMF)with different pulse frequencies and pulse voltages,at a superheat of 191℃,was investigated.The grains of the ingots are refined,decreasing from 3.9 mm without the application of PMF to 1.7 mm with PMF.Furthermore,the dendrite morphology undergoes a transformation,changing from well-developed branches to a global rosette pattern with rounded dendrite tips.However,it is worth noting that the secondary dendrite arm spacing increases under the influence of PMF.The refinement mechanism was investigated by quenching experiments and theoretical analysis under PMF.The high superheat of 191℃ results in a low cooling rate and a small thermal gradient during solidification,which promotes the survival of heterogeneous nuclei,leading to grain refinement.Additionally,evolutions in dendrite morphology are attributed to increased heterogeneous nucleation.When PMF is applied,the solidification structure is refined even under high superheat conditions.This leads to simultaneous improvements in filling ability and grain size refinement,offering promising applications for the practical manufacturing of thin-walled complex parts.展开更多
In this work,the solidification behavior and precipitation strengthening of Mg-8Zn-1Al-0.5Cu-0.5Mn(wt%,ZA81M)alloy solidified with different cooling rates of solidification were investigated.Selected area electron dif...In this work,the solidification behavior and precipitation strengthening of Mg-8Zn-1Al-0.5Cu-0.5Mn(wt%,ZA81M)alloy solidified with different cooling rates of solidification were investigated.Selected area electron diffraction(SAED)analysis revealed the presence of rod-like nano-particles with an Mg4Zn7 structure(βi′)and plate-like nano-particles with an MgZn2 structure(β2′).X-ray diffraction(XRD)and Energy dispersive spectrometer(EDS)indicate that the coarse second phases in the solidification structure are MgZn eutectic phase,MgZnCu separated eutectic phase,and AIMn phase.The effect of precipitation strengthening was caused by the precipitated phases in the solidified microstructure.The quantities of both β1′and β2′significantly decreased with an increase in cooling rate from 0.70℃·s-1 to 33.98℃·s-1,resulting in a reduction of Vickers hardness from 87.70 to 75.53 HV.The higher cooling rate of solidification effectively inhibited the formation of precipitates,thereby diminished the precipitation-strengthening effect.Two orientation relationships(ORs)were identified between the nano-particles β1′and β2′and the Mg substrate:basal and pyramidal precipitates,respectively.Specifically,the β1′phase exhibited the following ORs:(312)_(β1′)//(0002)Mg,(-912)_(β1′)//(10-11)Mg,(-1003)_(β1′)//(10-11)Mg,and(110)_(β1′)//(10-11)Mg.Moreover,the β2′phase exhibited ORs with basal and pyramidal planes,presented as(11-20)_(β2′)//(0002)Mg and(10-13)_(β2′)//(10-11)Mg.In addition,the variation of coarse second phase and nano-particle precipitated phase shows a competitive relationship,which is attributed to the microsegregation of Zn element.Precipitation strengthening mainly improves microhardness,and tensile mechanical properties are mainly affected by fine-grain strengthening.展开更多
The nonisospectral effectλ_t=α(t)λsatisfied by spectral parameterλopens up a new scheme for constructing localized waves to some nonlinear partial differential equations.In this paper,we perform this effect on a c...The nonisospectral effectλ_t=α(t)λsatisfied by spectral parameterλopens up a new scheme for constructing localized waves to some nonlinear partial differential equations.In this paper,we perform this effect on a complex nonisospectral nonpotential sine-Gordon equation by the bilinearization reduction method.From an integrable nonisospectral Ablowitz–Kaup–Newell–Segur equation,we construct some exact solutions in double Wronskian form to the reduced complex nonisospectral nonpotential sine-Gordon equation.These solutions,including soliton solutions,Jordan-block solutions and interaction solutions,exhibit localized structure,whose dynamics are analyzed with graphical illustration.The research ideas and methods in this paper can be generalized to other negative order nonisospectral integrable systems.展开更多
BACKGROUND Gastric cancer(GC)is one of the most common malignancies and types of cancer worldwide.AIM To compare the differences in tumor markers of GC with GC dissection,we evaluated the efficacy of recent tumor remo...BACKGROUND Gastric cancer(GC)is one of the most common malignancies and types of cancer worldwide.AIM To compare the differences in tumor markers of GC with GC dissection,we evaluated the efficacy of recent tumor removal.METHODS A prospective cohort study was conducted to analyze the clinical data of patients with GC.Patients were divided into two groups based on the surgical approach:The membrane dissection(MD)group,which underwent membrane-guided laparoscopic radical gastrectomy with D2 lymph node dissection plus complete mesocolic excision,and the D2 group,which underwent traditional laparoscopic radical gastrectomy with D2 lymph node dissection.Abdominal lavage fluid was collected pre-and postoperatively from patients in both groups.The expression of carcinoembryonic antigen(CEA)and cytokeratin-19(CK-19)message RNAs in the abdominal lavage fluid was detected using reverse transcription polymerase chain reaction.The factors influencing the increase of the tumor markers were analyzed,and the short-term efficacy of the two surgery types was compared.RESULTS In total,135 eligible patients were included in this study,with 69 and 66 cases in the MD and D2 groups,respectively.Fourteen patients with benign gastric lesions were selected to detect tumor marker expression.After excluding patients positive for preoperative cancer leakage,we found that 9.52%and 26.67%of patients in the MD and D2 groups developed postoperative CEA positivity,respectively.Multivariate analysis revealed that the degree of differentiation and surgical approach were independent risk factors for postoperative CEA positivity.The surgical approach was an independent risk factor affecting postoperative CK-19 positivity and postoperative CEA and CK-19 positivity.Surgical time,intraoperative blood loss,number of lymph nodes dissected,time to first postoperative flatus,and time to first liquid intake were all significantly different between the two surgical approaches.There were no significant differences in the incision length,duration of postoperative hospital stays,or postoperative complications.CONCLUSION MD is a better radical surgical treatment than traditional D2 surgery and is worthy of further clinical promotion and application.展开更多
The microstructure evolution and growth orientation of directionally solidified Mg-4 wt% Zn alloy in the growth rate range from 20 to 200μm/s were investigated. A typical cellular structure was observed with a growth...The microstructure evolution and growth orientation of directionally solidified Mg-4 wt% Zn alloy in the growth rate range from 20 to 200μm/s were investigated. A typical cellular structure was observed with a growth rate of 20 μm/s, and the cellular spacing was 115 μm. When the growth rate increased to 60 μm/s, cellular structure with some developed perturbations was obtained and the cellular spacing was 145 μm, suggesting that the cell-to-dendrite transition happened at the growth rate lower than 60 μm/s. As the growth rate further increased, the microstructure was dendritic and the primary dendritic arm spacing decreased. The relationship between the primary dendritic arm spacings and the growth rates was in good agreement with Trivedi model during dendritic growth. Besides, X-ray diffraction and transmission electron microscopy analyses showed that the growth direction of directionally solidified Mg-4 wt% Zn alloy was (1120) lay in {0002} crystal plane, and the preferred orientation was explained with the lattice vibration model for one-dimensional monatomic chain.展开更多
Carbon nanotube (CNT)-reinforced AZ91D alloy composite was fabricated by ultrasonic processing. The microstructure and mechanical properties of the CNTs/AZ91D composites were investigated. Obvious grain refinement w...Carbon nanotube (CNT)-reinforced AZ91D alloy composite was fabricated by ultrasonic processing. The microstructure and mechanical properties of the CNTs/AZ91D composites were investigated. Obvious grain refinement was achieved with the addition of 0.5 wt% CNTs. The SEM observation indicated that CNTs were distributed near the grain boundary or around the inter-grain β-Mg17A112 phase. No evident reaction product was found at the interface between CNTs and AZ91D matrix. Compared to the monolithic AZ91D alloy, the yield strength, ultimate tensile strength, and elongation of the 0.5 wt% CNTs/AZ91D composite were improved significantly. However, the poor interface bonding between CNTs and AZ91D matrix restricted further improvement in mechanical properties.展开更多
The second phase dissolution and elements migration behavior of a nickel-based single crystal superalloy during solution heat treatment with direct current were investigated for simplifying and shortening the solution...The second phase dissolution and elements migration behavior of a nickel-based single crystal superalloy during solution heat treatment with direct current were investigated for simplifying and shortening the solution heat treatment of the Ni-based single crystal superalloy.The results showed that the electric current solution heat treatment improved microstructural homogenization as well as the distribution of alloying elements,especially for the refractory metal W and Mo.The microsegregation ratios for Mo and W after electric current solution heat treatment at 1230℃for 4 h are near those without electric current at 1250℃for 4 h.The electric current accelerated theγ′phase dissolution process,and theγ′phase could be completely dissolved at a lower treatment temperature or within a shorter treatment time under electric current solution heat treatment with direct current.A microcosmic current model was proposed to analyze the effect of the electric current on the solution heat treatment of the Ni-based single crystal superalloy.展开更多
Environmental heterogeneity is a constant presence in the natural world that significantly affects plant behavior at a variety of levels of complexity. In order to estimate the spatial pattern of fine root biomass in ...Environmental heterogeneity is a constant presence in the natural world that significantly affects plant behavior at a variety of levels of complexity. In order to estimate the spatial pattern of fine root biomass in the Three Gorges Reservoir Area, the spatial heterogeneity of fine root biomass in the upper layer of soils (0-10 cm) in three Mas- son pine (Pinus massoniana) stands in the Three Gorges Reservoir Area, China, was studied in 30 m x 30 m plots with geostatistical analysis. The results indicate that 1) both the live and dead fine root biomass of stand 2 were less than those of other stands, 2) the spatial variation of fine roots in the three stands was caused together by structural and ran- dom factors with moderate spatial dependence and 3) the magnitude of spatial heterogeneity of live fine roots ranked as: stand 3 〉 stand 1 〉 stand 2, while that of dead fine roots was similar in the three stands. These findings suggested that the range of spatial autocorrelation for fine root biomass varied considerably in the Three Gorges Reservoir Area, while soil properties, such as soil bulk density, organic matter and total nitrogen, may exhibit great effect on the spatial distribution of fine roots. Finally, we express our hope to be able to carry out further research on the quantitative relation- ship between the spatial heterogeneous patterns of plant and soil properties.展开更多
OBJECTIVE: To identify a gene engineering antibody against cystic echinococcosis in liver. METHODS: A single chain of variable fragment of human antibodies (ScFvs) was selected from the library by using affinity selec...OBJECTIVE: To identify a gene engineering antibody against cystic echinococcosis in liver. METHODS: A single chain of variable fragment of human antibodies (ScFvs) was selected from the library by using affinity selection technique with the recombinant antigen on solid surface. The positive clones were demonstrated by ELISA and their DNA sequences were also determined. RESULTS: The DNA sequence data showed that the antibody gene is composed of 768bp. In addition, a specific combination capacity with recombinant Echinococcus granulosus antigen B (r-EgB) was demonstrated by ELISA. CONCLUSION: The obtained gene engineering antibody against r-EgB may have potential implications in immunological treatment and drug targeting delivery.展开更多
基金the financial support by the National Key Research and Development Program(No.2018YFA0702900)the National Science and Technology Major Project(No.J2019-Ⅶ-0002-0142)the National Natural Science Foundation of China(No.51831007)。
摘要The grain refinement effect of superalloy K4169 under a low-voltage pulsed magnetic field(PMF)with different pulse frequencies and pulse voltages,at a superheat of 191℃,was investigated.The grains of the ingots are refined,decreasing from 3.9 mm without the application of PMF to 1.7 mm with PMF.Furthermore,the dendrite morphology undergoes a transformation,changing from well-developed branches to a global rosette pattern with rounded dendrite tips.However,it is worth noting that the secondary dendrite arm spacing increases under the influence of PMF.The refinement mechanism was investigated by quenching experiments and theoretical analysis under PMF.The high superheat of 191℃ results in a low cooling rate and a small thermal gradient during solidification,which promotes the survival of heterogeneous nuclei,leading to grain refinement.Additionally,evolutions in dendrite morphology are attributed to increased heterogeneous nucleation.When PMF is applied,the solidification structure is refined even under high superheat conditions.This leads to simultaneous improvements in filling ability and grain size refinement,offering promising applications for the practical manufacturing of thin-walled complex parts.
基金supported by the National Key Research and Development Program of China(No.2021YFB3701100)the Applied Basic Research Program Project of Liaoning Province of China(No.2023020253-JH2/1016)the Key Research and Development Plan of Shanxi Province(No.202102050201005).
摘要In this work,the solidification behavior and precipitation strengthening of Mg-8Zn-1Al-0.5Cu-0.5Mn(wt%,ZA81M)alloy solidified with different cooling rates of solidification were investigated.Selected area electron diffraction(SAED)analysis revealed the presence of rod-like nano-particles with an Mg4Zn7 structure(βi′)and plate-like nano-particles with an MgZn2 structure(β2′).X-ray diffraction(XRD)and Energy dispersive spectrometer(EDS)indicate that the coarse second phases in the solidification structure are MgZn eutectic phase,MgZnCu separated eutectic phase,and AIMn phase.The effect of precipitation strengthening was caused by the precipitated phases in the solidified microstructure.The quantities of both β1′and β2′significantly decreased with an increase in cooling rate from 0.70℃·s-1 to 33.98℃·s-1,resulting in a reduction of Vickers hardness from 87.70 to 75.53 HV.The higher cooling rate of solidification effectively inhibited the formation of precipitates,thereby diminished the precipitation-strengthening effect.Two orientation relationships(ORs)were identified between the nano-particles β1′and β2′and the Mg substrate:basal and pyramidal precipitates,respectively.Specifically,the β1′phase exhibited the following ORs:(312)_(β1′)//(0002)Mg,(-912)_(β1′)//(10-11)Mg,(-1003)_(β1′)//(10-11)Mg,and(110)_(β1′)//(10-11)Mg.Moreover,the β2′phase exhibited ORs with basal and pyramidal planes,presented as(11-20)_(β2′)//(0002)Mg and(10-13)_(β2′)//(10-11)Mg.In addition,the variation of coarse second phase and nano-particle precipitated phase shows a competitive relationship,which is attributed to the microsegregation of Zn element.Precipitation strengthening mainly improves microhardness,and tensile mechanical properties are mainly affected by fine-grain strengthening.
基金supported by the National Natural Science Foundation of China(Grant No.12071432)Zhejiang Provincial Natural Science Foundation(Grant No.LZ24A010007)。
摘要The nonisospectral effectλ_t=α(t)λsatisfied by spectral parameterλopens up a new scheme for constructing localized waves to some nonlinear partial differential equations.In this paper,we perform this effect on a complex nonisospectral nonpotential sine-Gordon equation by the bilinearization reduction method.From an integrable nonisospectral Ablowitz–Kaup–Newell–Segur equation,we construct some exact solutions in double Wronskian form to the reduced complex nonisospectral nonpotential sine-Gordon equation.These solutions,including soliton solutions,Jordan-block solutions and interaction solutions,exhibit localized structure,whose dynamics are analyzed with graphical illustration.The research ideas and methods in this paper can be generalized to other negative order nonisospectral integrable systems.
基金Supported by Putian Science and Technology Plan Project,No.2022SY003.
摘要BACKGROUND Gastric cancer(GC)is one of the most common malignancies and types of cancer worldwide.AIM To compare the differences in tumor markers of GC with GC dissection,we evaluated the efficacy of recent tumor removal.METHODS A prospective cohort study was conducted to analyze the clinical data of patients with GC.Patients were divided into two groups based on the surgical approach:The membrane dissection(MD)group,which underwent membrane-guided laparoscopic radical gastrectomy with D2 lymph node dissection plus complete mesocolic excision,and the D2 group,which underwent traditional laparoscopic radical gastrectomy with D2 lymph node dissection.Abdominal lavage fluid was collected pre-and postoperatively from patients in both groups.The expression of carcinoembryonic antigen(CEA)and cytokeratin-19(CK-19)message RNAs in the abdominal lavage fluid was detected using reverse transcription polymerase chain reaction.The factors influencing the increase of the tumor markers were analyzed,and the short-term efficacy of the two surgery types was compared.RESULTS In total,135 eligible patients were included in this study,with 69 and 66 cases in the MD and D2 groups,respectively.Fourteen patients with benign gastric lesions were selected to detect tumor marker expression.After excluding patients positive for preoperative cancer leakage,we found that 9.52%and 26.67%of patients in the MD and D2 groups developed postoperative CEA positivity,respectively.Multivariate analysis revealed that the degree of differentiation and surgical approach were independent risk factors for postoperative CEA positivity.The surgical approach was an independent risk factor affecting postoperative CK-19 positivity and postoperative CEA and CK-19 positivity.Surgical time,intraoperative blood loss,number of lymph nodes dissected,time to first postoperative flatus,and time to first liquid intake were all significantly different between the two surgical approaches.There were no significant differences in the incision length,duration of postoperative hospital stays,or postoperative complications.CONCLUSION MD is a better radical surgical treatment than traditional D2 surgery and is worthy of further clinical promotion and application.
摘要The microstructure evolution and growth orientation of directionally solidified Mg-4 wt% Zn alloy in the growth rate range from 20 to 200μm/s were investigated. A typical cellular structure was observed with a growth rate of 20 μm/s, and the cellular spacing was 115 μm. When the growth rate increased to 60 μm/s, cellular structure with some developed perturbations was obtained and the cellular spacing was 145 μm, suggesting that the cell-to-dendrite transition happened at the growth rate lower than 60 μm/s. As the growth rate further increased, the microstructure was dendritic and the primary dendritic arm spacing decreased. The relationship between the primary dendritic arm spacings and the growth rates was in good agreement with Trivedi model during dendritic growth. Besides, X-ray diffraction and transmission electron microscopy analyses showed that the growth direction of directionally solidified Mg-4 wt% Zn alloy was (1120) lay in {0002} crystal plane, and the preferred orientation was explained with the lattice vibration model for one-dimensional monatomic chain.
基金supported by the National Natural Science Foundation of China(No.51274184)
摘要Carbon nanotube (CNT)-reinforced AZ91D alloy composite was fabricated by ultrasonic processing. The microstructure and mechanical properties of the CNTs/AZ91D composites were investigated. Obvious grain refinement was achieved with the addition of 0.5 wt% CNTs. The SEM observation indicated that CNTs were distributed near the grain boundary or around the inter-grain β-Mg17A112 phase. No evident reaction product was found at the interface between CNTs and AZ91D matrix. Compared to the monolithic AZ91D alloy, the yield strength, ultimate tensile strength, and elongation of the 0.5 wt% CNTs/AZ91D composite were improved significantly. However, the poor interface bonding between CNTs and AZ91D matrix restricted further improvement in mechanical properties.
基金The authors gratefully acknowledge the financial support by the National Key Research and Development Program(No.2018YFA0702900)National Science and Technology Major Project(No.J2019-VII-0002-0142)the National Natural Science Foundation of China(No.51831007).
摘要The second phase dissolution and elements migration behavior of a nickel-based single crystal superalloy during solution heat treatment with direct current were investigated for simplifying and shortening the solution heat treatment of the Ni-based single crystal superalloy.The results showed that the electric current solution heat treatment improved microstructural homogenization as well as the distribution of alloying elements,especially for the refractory metal W and Mo.The microsegregation ratios for Mo and W after electric current solution heat treatment at 1230℃for 4 h are near those without electric current at 1250℃for 4 h.The electric current accelerated theγ′phase dissolution process,and theγ′phase could be completely dissolved at a lower treatment temperature or within a shorter treatment time under electric current solution heat treatment with direct current.A microcosmic current model was proposed to analyze the effect of the electric current on the solution heat treatment of the Ni-based single crystal superalloy.
基金supported by the Special Fund of National Forestry Public Welfare of the State Forestry Administration (No.201104008)a Special Fund of the Research Institute of Forest Ecology, Environment and Protection of the Chinese Academy of Forestry, China (No. CAFRIFEEP201006)
摘要Environmental heterogeneity is a constant presence in the natural world that significantly affects plant behavior at a variety of levels of complexity. In order to estimate the spatial pattern of fine root biomass in the Three Gorges Reservoir Area, the spatial heterogeneity of fine root biomass in the upper layer of soils (0-10 cm) in three Mas- son pine (Pinus massoniana) stands in the Three Gorges Reservoir Area, China, was studied in 30 m x 30 m plots with geostatistical analysis. The results indicate that 1) both the live and dead fine root biomass of stand 2 were less than those of other stands, 2) the spatial variation of fine roots in the three stands was caused together by structural and ran- dom factors with moderate spatial dependence and 3) the magnitude of spatial heterogeneity of live fine roots ranked as: stand 3 〉 stand 1 〉 stand 2, while that of dead fine roots was similar in the three stands. These findings suggested that the range of spatial autocorrelation for fine root biomass varied considerably in the Three Gorges Reservoir Area, while soil properties, such as soil bulk density, organic matter and total nitrogen, may exhibit great effect on the spatial distribution of fine roots. Finally, we express our hope to be able to carry out further research on the quantitative relation- ship between the spatial heterogeneous patterns of plant and soil properties.
基金supported by the Key Research and Development Plan of Shandong Province,China(No.2019JZZY020329)the National Key Research and Development Program of China(No.2017YFB0103904)+1 种基金the National Natural Science Foundation of China(No.51701211)Dongguan Innovative Research Team Program,China(No.2020607134012)。
基金The project was supported by a grant from the National Natural Science Fundation of China (No. 39860078) and Xinjiang Natural Science Fundation China (No. 200221101).
摘要OBJECTIVE: To identify a gene engineering antibody against cystic echinococcosis in liver. METHODS: A single chain of variable fragment of human antibodies (ScFvs) was selected from the library by using affinity selection technique with the recombinant antigen on solid surface. The positive clones were demonstrated by ELISA and their DNA sequences were also determined. RESULTS: The DNA sequence data showed that the antibody gene is composed of 768bp. In addition, a specific combination capacity with recombinant Echinococcus granulosus antigen B (r-EgB) was demonstrated by ELISA. CONCLUSION: The obtained gene engineering antibody against r-EgB may have potential implications in immunological treatment and drug targeting delivery.