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The application of multi-combinatorial approach in sensitivity improvement of lipid photoacoustic imaging 认领 引用 被引量：2
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作者 Yi Tan Dongjian Wu +4 位作者 Xiatian Wang Chengbo Liu Mingjian Sun Xiaojing Gong Zhihua Xie 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2026年第1期96-109,共14页
The photoacoustic imaging of lipid is intrinsically constrained by the feeble nature of endogenous lipid signals,posing a persistent sensitivity challenge that demands innovative solutions.Although adopting high-effic... The photoacoustic imaging of lipid is intrinsically constrained by the feeble nature of endogenous lipid signals,posing a persistent sensitivity challenge that demands innovative solutions.Although adopting high-efficiency excitation and detection elements may improve the imaging sensitivity to a certain extent,the application of the elements is inevitably subject to various limitations in practical applications,particularly during in vivo imaging and endoscopic imaging.In this study,we propose a multi-combinatorial approach to enhance the sensitivity of lipid photoacoustic imaging.The approach involves wavelet transform processing of one-dimensional A-line signals,gradient-based denoising of two-dimensional B-scan images,and finally,threedimensional spatial weighted averaging of the data processed by the previous two steps.This method not only significantly improves the signal-to-noise ratio(SNR)in distinguished feature regions of the image by around 10 dB,but also efficiently extracts weak signals with no distinct features in the original image.After processing with this method,the images acquired under single scanning were compared with those obtained under multiple scanning.The results showed highly consistent image features,with the structural similarity index increasing from 0.2 to 0.8,confirming the accuracy and reliability of the multi-combinatorial approach. 展开更多
关键词 Multi-combinatorial approach extraction of weak signals imaging sensitivity photoacoustic lipid imaging
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Highly Sensitive MoS_2–Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep Site 认领 引用 被引量：14
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作者 Chengbo Liu Jingqin Chen +9 位作者 Ying Zhu Xiaojing Gong Rongqin Zheng Ningbo Chen Dong Chen Huixiang Yan Peng Zhang Hairong Zheng Zonghai Sheng Liang Song 《Nano-Micro Letters》 SCIE EI CAS 2018年第3期115-126,共12页
Photoacoustic technology in combination with molecular imaging is a highly effective method for accurately diagnosing brain glioma. For glioma detection at a deeper site, contrast agents with higher photoacoustic imag... Photoacoustic technology in combination with molecular imaging is a highly effective method for accurately diagnosing brain glioma. For glioma detection at a deeper site, contrast agents with higher photoacoustic imaging sensitivity are needed. Herein, we report a MoS_2–ICG hybrid with indocyanine green(ICG) conjugated to the surface of MoS_2 nanosheets. The hybrid significantly enhanced photoacoustic imaging sensitivity compared to MoS_2 nanosheets. This conjugation results in remarkably high optical absorbance across a broad near-infrared spectrum, redshifting of the ICG absorption peak and photothermal/photoacoustic conversion efficiency enhancement of ICG. A tumor mass of 3.5 mm beneath the mouse scalp was clearly visualized by using MoS_2–ICG as a contrast agent for the in vivo photoacoustic imaging of orthotopic glioma, which is nearly twofold deeper than the tumors imaged in our previous report using MoS_2 nanosheet. Thus, combined with its good stability and high biocompatibility, the MoS_2–ICG hybrid developed in this study has a great potential for high-efficiency tumor molecular imaging in translational medicine. 展开更多
关键词 MoS2–ICG hybrid Orthotopic brain glioma Photoacoustic imaging Molecular imaging
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A review of complications of polyacrylamide hydrogel injection 认领 引用 被引量：1
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作者 Chenlu Xiong Youbai Chen +7 位作者 Yujian Xu Weiqian Jiang Xiangye Yin Dongsheng Chen Xiaojing Gong Tian He Yang An Yan Han 《Chinese Journal of Plastic and Reconstructive Surgery》 2023年第2期86-95,共10页
Once a popular injectable filler,polyacrylamide hydrogel(PAAG)has been banned in China since 2006 due to its unclear safety and long-term complications.However,it is still being used worldwide because of its huge comm... Once a popular injectable filler,polyacrylamide hydrogel(PAAG)has been banned in China since 2006 due to its unclear safety and long-term complications.However,it is still being used worldwide because of its huge commercial profit,leading to emerging complications and an urgent need for standardized clinical management.This review aimed to assess the properties,safety,and complications of PAAG and treatment strategies for its removal. 展开更多
关键词 Polyacrylamide hydrogel Fillers Complications Treatment Removal
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First-principles analysis of phonon thermal transport properties of two-dimensional WS2/WSe2 heterostructures 认领 引用
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作者 Zheng Chang Kunpeng Yuan +4 位作者 Zhehao Sun Xiaoliang Zhang Yufei Gao Xiaojing Gong Dawei Tang 《Chinese Physics B》 SCIE EI CAS CSCD 2021年第3期25-35,共11页
The van der Waals(vdW)heterostructures of bilayer transition metal dichalcogenide obtained by vertically stacking have drawn increasing attention for their enormous potential applications in semiconductors and insulat... The van der Waals(vdW)heterostructures of bilayer transition metal dichalcogenide obtained by vertically stacking have drawn increasing attention for their enormous potential applications in semiconductors and insulators.Here,by using the first-principles calculations and the phonon Boltzmann transport equation(BTE),we studied the phonon transport properties of WS2/WSe2 bilayer heterostructures(WS2/WSe2-BHs).The lattice thermal conductivity of the ideal WS2/WSe2-BHs crystals at room temperature(RT)was 62.98 W/mK,which was clearly lower than the average lattice thermal conductivity of WS2 and WSe2 single layers.Another interesting finding is that the optical branches below 4.73 THz and acoustic branches have powerful coupling,mainly dominating the lattice thermal conductivity.Further,we also noticed that the phonon mean free path(MFP)of the WS2/WSe2-BHs(233 nm)was remarkably attenuated by the free-standing monolayer WS2(526 nm)and WSe2(1720 nm),leading to a small significant size effect of the WS2/WSe2-BHs.Our results systematically demonstrate the low optical and acoustic phonon modes-dominated phonon thermal transport in heterostructures and give a few important guidelines for the synthesis of van der Waals heterostructures with excellent phonon transport properties. 展开更多
关键词 WS2/WSe2 bilayer heterostructures thermal transport first-principles Boltzmann transport equation
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The Hematopoietic and Immunomodulatory Effect of rhIL-12 for Liver Cancer 认领 引用
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作者 Xiaojing Gong Na Guo +2 位作者 Lingqin Wan Xifeng Jia Yishan Wang 《International Journal of Medical Physics, Clinical Engineering and Radiation Oncology》 2016年第1期33-41,共9页
Purpose: To explore the effect of rhIL-12 on the number of the blood cells and CD4/8+ T, CD45+ leukocytes, and CD56+ NK cells in liver cancer patients following radiation therapy. Methods: We selected forty liver canc... Purpose: To explore the effect of rhIL-12 on the number of the blood cells and CD4/8+ T, CD45+ leukocytes, and CD56+ NK cells in liver cancer patients following radiation therapy. Methods: We selected forty liver cancer patients who carried out by cyber knife (the patients were given 5 Gy every time for 5 times continuously) to observe the size of the tumor. After thirty hours, rhIL-12 was injected into the liver cancer patients via subcutaneous at the concentration of 50 ng/kg, 100 ng/kg, 200 ng/kg and 300 ng/kg in different patients, respectively. And there were ten patients in the four groups, respectively. The twenty patients who were selected from the hospital without rhIL-12 treatment were used as controls. All the blood cells were collected from different groups on day 0, hour 12, day 7, day 14, day 21 and day 28 after rhIL-12 treatment, respectively. The full number of blood cells in every group was analyzed by ELISA. The number of CD4/8+ T, CD45+ leukocytes, and CD56+ NK cells were detected by Flow Cytometry. After one month with rhIL-12 treatment, ECOG and WHO were used to evaluate the prognosis of liver cancer. Results: In present study, we found that the number of blood cells was significantly decreased on day 0 - day 3, while recovered from day 7 - day 14 and down-regulated on day 21 after rhIL-12 treatment. The number of CD4/8+ T, CD45+ leukocytes, and CD56+ NK cells was elevated with any concentration of rhIL-12. Furthermore, results showed that number of white blood cells was obviously higher than in patients without rhIL-12 treatment (P < 0.05). However, there was no significant difference of erythrocyte and platelet, between groups treated with rhIL-12 and control groups. In addition, the immune cells including CD4/8+ T, CD45+ leukocytes, and CD56+ NK cells were reduced on day 0 - day 3, recovered from day 7, and then decreased from day 21 in rhIL-12 treatment groups related to control groups (P < 0.05). Furthermore, studies showed that five patients developed symptoms of fever, bilirubin increased and liver dysfunction with the dose of 300 ng/kg. So we found that the safe and well-tolerated human dose of 200 ng/kg is within this efficacious range based on exposure parameters through the research. Higher ECOG and WHO scores were observed in rhIL-12 treatment groups compared to control groups (P = 0.025, P = 0.044, respectively). Conclusion: Our results suggested that rhIL-12 could recover the liver cancer induced aberrant blood cell number and CD4/8+ T, CD45+ leukocytes, and CD56+ NK cells , which may be an effective method to alleviate the progress of liver cancer and played an important role in treating liver cancer. 展开更多
关键词 rhIL-12 Liver Cancer Blood Cells CD4/8+ T CD45+ Leukocytes CD56+ NK Cells
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A Review for Ionic Selectivity inside Solid-State Nanoscale Channels: Physics and Applications 认领 引用
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作者 Xiaojing Gong 《化学发展前沿（中英文版）》 2013年第3期47-53,共7页
Ionic selectivity across nanochannels is of great importance to biological activities as well as the design of novel molecular devices/sensors which has wide potential applications in nanotechnology. With the developm... Ionic selectivity across nanochannels is of great importance to biological activities as well as the design of novel molecular devices/sensors which has wide potential applications in nanotechnology. With the development of experimental and computational facilities and technologies, it becomes possible to study the ionic selectivity inside and across the nanoscale channels by both experiments and simulations. Because of the confinement effect, there are new physical phenomena in such nanotube that are not observed at macrofluidic or microfluidic size scales, including the anomalous hydration shell order, ionic selectivity based on the surface charge. These novel properties build the foundation for the selectivity of the various types of ions. Several controlling methods to select ions are designed and developed, such as a controllable ion-selective nanopore （for selecting K＋ and Na＋） based on a single-walled carbon nanotube with specially arranged carbonyl oxygen atoms modified inside the nanopore, which was inspired by the structure of biological ionic channels. Nanopores in graphene sheets with different functional units have been applied to sieve cations of alkali metals or anions of group 17 element, respectively. The pore radius can also be determinant factor to choose ions. Recently, the separation of the positive and negative ions has appealed more concerns. Inside of nanofluidic nanopores, negative and positive ions are manipulated analogously to semiconductor devices such as metal-oxide-semiconductor field effect transistors, where negative and positive charged carriers are manipulated. In this review, we examine some of the recent advances in the dynamics of the ionic selectivity inside solid state nanoscale channels. 展开更多
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Advancement in PMN-PT transparent piezoelectric ceramic for photoacoustic/ultrasound dual-mode imaging 认领 引用 被引量：3
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作者 Pengkun Guo Wen Gao +14 位作者 Riqiang Lin Xiatian Wang Jiale Lan Jiaming Zhang Yanan Wang Lin Zhu Yongcheng Zhang Feng Li Weijie Zheng Tianlong Zhao Kwok-Ho Lam Xiaojing Gong Zhihua Xie Yalin Qin Shujun Zhang 《Journal of Materiomics》 SCIE CSCD 2025年第4期51-61,共11页
Dual-mode imaging combining photoacoustic and ultrasound modalities holds great promise for comprehensive tissue characterization.In traditional dual-mode imaging systems,however,the opaque ultrasound transducers are ... Dual-mode imaging combining photoacoustic and ultrasound modalities holds great promise for comprehensive tissue characterization.In traditional dual-mode imaging systems,however,the opaque ultrasound transducers are integrated in complex optical and ultrasound paths,leading to compromises in imaging efficiency and sensitivity.To address these challenges,we design and produce highly transparent Pb(Mg,Nb)O3-PbTiO3 ceramics with exceptional transparency of 68%,alongside a remarkable ultrahigh piezoelectric d33 of 1500 pC/N.Leveraging this material,we fabricate a high-sensitivity transparent piezoelectric ultrasound transducer(TPUT)with a center frequency of 16 MHz and a bandwidth of 30%,which seamlessly integrating ultrasound and photoacoustic capabilities into one system to achieve simultaneous photoacoustic/ultrasound dual-mode imaging,showcasing a remarkable sensitivity for deep-tissue detection(e.g.,7.5 mm thick chicken breast meat).Additionally,in vivo photoacoustic imaging of subcutaneous microvasculature in a mouse ear was successfully achieved via 28 MHz TPUT.Our innovation not only advances imaging performance but also offers a cost-effective solution,paving the way for transformative biomedical imaging applications. 展开更多
关键词 PMN-PT Transparent ceramics Transparent piezoelectric ultrasonic transducer Photoacoustic/ultrasound dual-mode imaging Photoacoustic imaging
High-energy all-fiber gain-switched thulium-doped fiber laser for volumetric photoacoustic imaging of lipids 认领 引用 被引量：11
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作者 CAN LI JIAWEI SHI +4 位作者 XIATIAN WANG BOQUAN WANG XIAOJING GONG LIANG SONG KENNETH K.Y.WONG 《Photonics Research》 SCIE EI CAS CSCD 2020年第2期160-164,共5页
We demonstrate a high-energy all-fiber short wavelength gain-switched thulium-doped fiber laser for volumetric photoacoustic(PA)imaging of lipids.The laser cavity is constructed by embedding a short piece of gain fibe... We demonstrate a high-energy all-fiber short wavelength gain-switched thulium-doped fiber laser for volumetric photoacoustic(PA)imaging of lipids.The laser cavity is constructed by embedding a short piece of gain fiber between a pair of fiber Bragg gratings(FBGs).Through using three pairs of FBGs with operation wavelengths at1700,1725,and 1750 nm,three similar lasers are realized with a cavity length of around 25 cm.Under a maximum pump energy of 300μJ at 1560 nm,laser pulse energies of 58.2,66.8,and 75.3μJ are,respectively,achieved with a minimum pulse width of<16.7 ns at a repetition rate of 10 kHz.Volumetric imaging of lipids is validated through scanning a fat beef slice with a PA microscopy system incorporated with the newly developed source,and a lateral resolution of 18.8μm and an axial resolution of 172.9μm are achieved.Moreover,the higher shooting speed of the developed source can potentially allow for increasing at twice the frame rate of current intravascular PA imaging. 展开更多
关键词 fiber switched laser
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