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The electrical properties and charge transport mechanism of MXenes 认领 引用
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作者 Bowen Song Chenxu Shi +4 位作者 Yinghao Qu Hongjun Liu Hui Yang Xiaoming Wu Xijun Liu 《Chinese Chemical Letters》 SCIE CAS CSCD 2025年第6期13-14,共2页
Two-dimensional(2D)transition metal carbides and/or nitrides(MXenes)have exhibited many outstanding merits,including good conductivity,tunable bandgap,high electric capacity and optical transparency[1,2].In the past s... Two-dimensional(2D)transition metal carbides and/or nitrides(MXenes)have exhibited many outstanding merits,including good conductivity,tunable bandgap,high electric capacity and optical transparency[1,2].In the past several years,MXenes have shown promising advantages in the fields of energy storage,electrocatalysis,electromagnetic shielding,and(opto-)electronic devices.These excellent properties can be tuned by controlling the chemical composition,shape and size of the nanosheets,defects,boundaries,and surface functional groups,etc. 展开更多
关键词 nano sheets transition metal carbides two dimensional electrical properties energy storage electrocatalysis electromagnetic shielding and opto electronic mxenes chemical composition charge transport
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SW-DDFT: Parallel Optimization of the Dynamical Density Functional Theory Algorithm Based on Sunway Bluelight II Supercomputer 认领 引用
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作者 Xiaoguang Lv Tao Liu +5 位作者 Han Qin Ying Guo Jingshan Pan Dawei Zhao Xiaoming Wu Meihong Yang 《Computers, Materials & Continua》 SCIE EI 2025年第7期1417-1436,共20页
The Dynamical Density Functional Theory(DDFT)algorithm,derived by associating classical Density Functional Theory(DFT)with the fundamental Smoluchowski dynamical equation,describes the evolution of inhomo-geneous flui... The Dynamical Density Functional Theory(DDFT)algorithm,derived by associating classical Density Functional Theory(DFT)with the fundamental Smoluchowski dynamical equation,describes the evolution of inhomo-geneous fluid density distributions over time.It plays a significant role in studying the evolution of density distributions over time in inhomogeneous systems.The Sunway Bluelight II supercomputer,as a new generation of China’s developed supercomputer,possesses powerful computational capabilities.Porting and optimizing industrial software on this platform holds significant importance.For the optimization of the DDFT algorithm,based on the Sunway Bluelight II supercomputer and the unique hardware architecture of the SW39000 processor,this work proposes three acceleration strategies to enhance computational efficiency and performance,including direct parallel optimization,local-memory constrained optimization for CPEs,and multi-core groups collaboration and communication optimization.This method combines the characteristics of the program’s algorithm with the unique hardware architecture of the Sunway Bluelight II supercomputer,optimizing the storage and transmission structures to achieve a closer integration of software and hardware.For the first time,this paper presents Sunway-Dynamical Density Functional Theory(SW-DDFT).Experimental results show that SW-DDFT achieves a speedup of 6.67 times within a single-core group compared to the original DDFT implementation,with six core groups(a total of 384 CPEs),the maximum speedup can reach 28.64 times,and parallel efficiency can reach 71%,demonstrating excellent acceleration performance. 展开更多
关键词 Sunway supercomputer high-performance computing dynamical density functional theory parallel optimization
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UHPLC-MS/MS法检测化妆品中21种非甾体抗炎药 认领 引用 被引量：3
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作者 冯克然 吴晓鸣 +1 位作者 马亮波 孙宇 《日用化学工业（中英文）》 CAS 北大核心 2025年第3期399-406,共8页
建立了同时检测化妆品中21种非甾体抗炎药的UHPLC-MS/MS方法。选用膏霜、面膜、凝胶、液体水基类样品为化妆品代表性基质,样品采用甲醇或0.3%(V/V)甲酸-甲醇进行超声辅助液液萃取。使用ACQUITY UPLC BEH C18(1.7μm,2.1 mm×150 ... 建立了同时检测化妆品中21种非甾体抗炎药的UHPLC-MS/MS方法。选用膏霜、面膜、凝胶、液体水基类样品为化妆品代表性基质,样品采用甲醇或0.3%(V/V)甲酸-甲醇进行超声辅助液液萃取。使用ACQUITY UPLC BEH C18(1.7μm,2.1 mm×150 mm)色谱柱进行分离,分别以0.1%(V/V)甲酸-水和乙腈作为水相和有机相进行梯度洗脱,在多反应监测模式下进行检测。对样品前处理条件和色谱、质谱条件进行了系统性考察。结果表明,20种化合物的线性范围为5~50μg/L,罗非昔布线性范围为10~100μg/L,均线性相关系数良好(r>0.99)。低、中、高三个浓度水平的加标回收率范围为72.1%~117.3%(n=6),相对标准偏差RSD范围为0.6%~9.7%。该方法操作简便、准确性高、灵敏度好,适用于化妆品中非甾体抗炎药的检测,能够为化妆品中行为的监管提供技术支撑。 展开更多
关键词 超高效液相色谱-串联质谱 化妆品 非甾体抗炎药
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Comparison and Verification of the Potential Applicability of BaTi4O9in the Field of Photocatalytic H2Evolution 认领 引用
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作者 Mengjie CUI Imran MUHAMMADA +3 位作者 Tiezhen REN Xinwei YANG Pengfei LIU Xiaoming WU 《Research and Application of Materials Science》 2025年第1期22-30,共9页
Photocatalytic hydrogen evolution is of great importance with the proceeding of dual carbon goals,for inorganic catalysts have been explored with high efficiency.The structure and properties of oxide composites might ... Photocatalytic hydrogen evolution is of great importance with the proceeding of dual carbon goals,for inorganic catalysts have been explored with high efficiency.The structure and properties of oxide composites might take advantage of each compound and display an increased activity.In our previous study,boron doped-Cu3NiBaTi4O9possessed a porous structure and its photocurrent response was apparent.To further verify its excellent catalytic activity,Al2O3,and SiO2 were selected to replace with BaTi4O9to prepare different composites.The physical and chemical features of each sample were characterized with SEM,XRD,XPS,etc.to reveal their structural variations.Correspondingly,the H2evolution rate was investigated with gas chromatography under the sunlight irritation.A distinct hydrogen yield was recorded with prepared samples.Further,the projected density of states analysis was taken through density functional theory calculations to appreciate the conduction band of the composite.The offered electrons during the photocatalytic process and the potential applicability of composites in the field of photocatalysis was verified. 展开更多
关键词 Photocatalytic H2evolution B doped Cu3Ni/BaTi4O9 Porous structure DFT calculation
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Performance Limits and Advancements in Single 2D Transition Metal Dichalcogenide Transistor 认领 引用 被引量：3
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作者 Jing Chen Ming-Yuan Sun +8 位作者 Zhen-Hua Wang Zheng Zhang Kai Zhang Shuai Wang Yu Zhang Xiaoming Wu Tian-Ling Ren Hong Liu Lin Han 《Nano-Micro Letters》 SCIE EI CAS CSCD 2024年第12期134-188,共55页
Two-dimensional(2D)transition metal dichalcogenides(TMDs)allow for atomic-scale manipulation,challenging the conventional limitations of semiconductor materials.This capability may overcome the short-channel effect,sp... Two-dimensional(2D)transition metal dichalcogenides(TMDs)allow for atomic-scale manipulation,challenging the conventional limitations of semiconductor materials.This capability may overcome the short-channel effect,sparking significant advancements in electronic devices that utilize 2D TMDs.Exploring the dimension and performance limits of transistors based on 2D TMDs has gained substantial importance.This review provides a comprehensive investigation into these limits of the single 2D-TMD transistor.It delves into the impacts of miniaturization,including the reduction of channel length,gate length,source/drain contact length,and dielectric thickness on transistor operation and performance.In addition,this review provides a detailed analysis of performance parameters such as source/drain contact resistance,subthreshold swing,hysteresis loop,carrier mobility,on/off ratio,and the development of p-type and single logic transistors.This review details the two logical expressions of the single 2D-TMD logic transistor,including current and voltage.It also emphasizes the role of 2D TMD-based transistors as memory devices,focusing on enhancing memory operation speed,endurance,data retention,and extinction ratio,as well as reducing energy consumption in memory devices functioning as artificial synapses.This review demonstrates the two calculating methods for dynamic energy consumption of 2D synaptic devices.This review not only summarizes the current state of the art in this field but also highlights potential future research directions and applications.It underscores the anticipated challenges,opportunities,and potential solutions in navigating the dimension and performance boundaries of 2D transistors. 展开更多
关键词 Two-dimensional transistors Dimension limits Performance limits Memory devices Artificial synapses
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The activation of gene expression and alternative splicing in the formation and evolution of allopolyploid Brassica napus 认领 引用 被引量：3
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作者 Mengdi Li Meimei Hu +2 位作者 Yafang Xiao Xiaoming Wu Jianbo Wang 《Horticulture Research》 SCIE CSCD 2022年第1期973-984,共12页
Allopolyploids contain two ormore sets of subgenomes.To establish a compatible relationship between subgenomes,a series of gene expression changes has occurred in allopolyploids.What evolutionary changes have taken pl... Allopolyploids contain two ormore sets of subgenomes.To establish a compatible relationship between subgenomes,a series of gene expression changes has occurred in allopolyploids.What evolutionary changes have taken place in transcripts of Brassica napus during its early establishment and subsequent evolution is a fascinating scientific question.Here,we study this issue using a set of materials(natural and resynthesized B.napus and their progenitors/parents)and long-read RNA sequencing technology.The results showed that more genes were upregulated in resynthesized B.napus compared with its two parents,and more upregulated expressed genes were observed in natural B.napus than in resynthesized B.napus.The presence of upregulated genes in an organism may help it to adapt to the influence of“genomic shock”and cope with the natural environment.Isoforms are produced from precursor mRNAs by alternative splicing(AS)events,and more than 60%of the isoforms identified in all materials were novel,potentially improving the reference genome information for B.napus.We found that the isoform numbers and the numbers of genes potentially involved in AS and alternative polyadenylation increased in B.napus after evolution,and they may have been involved in the adaptation of plants to the natural environment.In addition,all identified isoforms were functionally annotated by searching seven databases.In general,this study can improve our overall understanding of the full-length transcriptome of B.napus and help us to recognize the significant changes in gene expression and isoform abundance that have occurred in allopolyploid B.napus during evolution. 展开更多
关键词 brassica napus gene expression changes evolutionary changes genomic shock establish compatible relationship alternative splicing allopolyploid gene expression
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Transcriptome analysis reveals genes expression pattern of seed response to heat stress in Brassica napus L. 认领 引用 被引量：4
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作者 Guizhen Gao Jihong Hu +3 位作者 Xiaojun Zhang Fugui Zhang Mei Li Xiaoming Wu 《Oil Crop Science》 CSCD 2021年第2期87-96,共10页
Seeds might deteriorate,and lose the ability to germinate when stored under high temperature and high humidity.Brassica napus is one of the most important oil crops in China.However,B.napus seeds were generally stored... Seeds might deteriorate,and lose the ability to germinate when stored under high temperature and high humidity.Brassica napus is one of the most important oil crops in China.However,B.napus seeds were generally stored through summer season with high ambient temperature,which lead to seed viability loss.In order to understand the mechanism of seed response to heat stress and improve seed heat tolerance,B.napus seeds were treated with high temperature(40℃)and ultra-high temperature(60℃)for 4 h.The germination of heatstressed seeds were obviously slower,the germination index and vigor index decreased with temperature increase from 40 to 60℃,and the 40℃ pretreatment could improve the seed tolerance to 60℃ heat stress.Transcriptomics results showed that 442 differentially expressed genes(DEGs)were identified in seeds after heat stress.Gene ontology and KEGG pathway enrichment analysis revealed that some of the genes were involved in posttranslational modification,protein turnover,chaperones and carbohydrate transport,metabolic pathways and secondary metabolites biosynthesis pathway.Among these DEGs,sHSP and transcription factors genes were involved in heat stress tolerance.Thirty-two overlapping genes under different high temperature stress(40℃ and 60℃)were enriched in biological processes of response to oxidative stress and abiotic stimulus.The expression trends of 12 genes randomly selected from the RNA-seq data were almost consistent with the results of qRT-PCR.Our results revealed several potential candidate genes and pathways related to heat responsive by high temperature,which is beneficial for further improving the heat tolerance in B.napus seeds. 展开更多
关键词 Brassica napus L. Seed Heat stress Transcriptome analyses
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p53 mutation regulates PKD genes and results in co-occurrence of PKD and tumorigenesis 认领 引用 被引量：1
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作者 Haili Li Yongjin Zhang +8 位作者 Juhua Dan Ruoyu Zhou Cui Li Rong Li Xiaoming Wu Sanjay Kumar Singh Jeffrey T.Chang Julun Yang Ying Luo 《Cancer Biology & Medicine》 SCIE CAS CSCD 2019年第1期79-88,共10页
Objective: Polycystic kidney disease(PKD) is the major cause of kidney failure and mortality in humans. It has always been suspected that the development of cystic kidney disease shares features with tumorigenesis, al... Objective: Polycystic kidney disease(PKD) is the major cause of kidney failure and mortality in humans. It has always been suspected that the development of cystic kidney disease shares features with tumorigenesis, although the evidence is unclear.Methods: We crossed p53 mutant mice(p53N236S, p53S) with Werner syndrome mice and analyzed the pathological phenotypes.The RNA-seq, ss GSEA analysis, and real-time PCR were performed to dissect the gene signatures involved in the development of disease phenotypes.Results: We found enlarged kidneys with fluid-filled cysts in offspring mice with a genotype of G3mTerc-/-WRN-/-p53S/S(G3TM).Pathology analysis confirmed the occurrence of PKD, and it was highly correlated with the incidence of tumorigenesis. RNA-seq data revealed the gene signatures involved in PKD development, and demonstrated that PKD and tumorigenesis shared common pathways, including complement pathways, lipid metabolism, mitochondria energy homeostasis and others. Interestingly, this G3TM PKD and the classical PKD1/2 deficient PKD shared common pathways, possibly because the mutant p53S could regulate the expression levels of PKD1/2, Pkhd1, and Hnf1b.Conclusions: We established a dual mouse model for PKD and tumorigenesis derived from abnormal cellular proliferation and telomere dysfunction. The innovative point of our study is to report PKD occurring in conjunction with tumorigenesis. The gene signatures revealed might shed new light on the pathogenesis of PKD, and provide new molecular biomarkers for clinical diagnosis and prognosis. 展开更多
关键词 p53 mutation telomere dysfunction polycystic kidney disease tumorigenesis
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The characteristics of mRNA m6A methylomes in allopolyploid Brassica napus and its diploid progenitors 认领 引用 被引量：1
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作者 Zeyu Li Mengdi Li +1 位作者 Xiaoming Wu Jianbo Wang 《Horticulture Research》 SCIE CSCD 2023年第1期69-81,共13页
Genome duplication events,comprising whole-genome duplication and single-gene duplication,produce a complex genomic context leading to multiple levels of genetic changes.However,the characteristics of m6A modificat... Genome duplication events,comprising whole-genome duplication and single-gene duplication,produce a complex genomic context leading to multiple levels of genetic changes.However,the characteristics of m6A modification,the most widespread internal eukaryotic mRNA modification,in polyploid species are still poorly understood.This study revealed the characteristics of m6A methylomes within the early formation and following the evolution of allopolyploid Brassica napus.We found a complex relationship between m6A modification abundance and gene expression level depending on the degree of enrichment or presence/absence of m6A modification.Overall,the m6A genes had lower gene expression levels than the non-m6A genes.Allopolyploidization may change the expression divergence of duplicated gene pairs with identical m6A patterns and diverged m6A patterns.Compared with duplicated genes,singletons with a higher evolutionary rate exhibited higher m6A modification.Five kinds of duplicated genes exhibited distinct distributions of m6A modifications in transcripts and gene expression level.In particular,tandem duplication-derived genes showed unique m6A modification enrichment around the transcript start site.Active histone modifications(H3K27ac and H3K4me3)but not DNA methylation were enriched around genes of m6A peaks.These findings provide a new understanding of the features of m 6A modification and gene expression regulation in allopolyploid plants with sophisticated genomic architecture. 展开更多
关键词 polyp characteristics progenitor
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Functional localization of the cortical motor area in the brain Electrocorticogram analysis 认领 引用
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作者 Tao Jiang Xiaoming Wu +1 位作者 Binggang Ye Sijuan Huang 《Neural Regeneration Research》 SCIE CAS 2010年第19期1480-1485,共6页
The method for rapidly,precisely and non-invasively localizing functional regions of the brain is a problem in neuromedicine research.Cortical electrostimulation is the optimal localization method during brain surgery... The method for rapidly,precisely and non-invasively localizing functional regions of the brain is a problem in neuromedicine research.Cortical electrostimulation is the optimal localization method during brain surgery,with a degree of accuracy of approximately 5 mm.However,electrostimulation can damage the cerebral cortex,trigger epilepsy,and extend the operation time.Studies are required to determine whether cortical motor regions can be localized by wavelet analysis from electrocorticograms.In this study,based on wavelet analysis of electrocorticograms,a selection of algorithms for classification of the mu rhythm in the motor regions utilizing experimental data was verified.Results demonstrated that a characteristic quantity of energy ratio in the reconstructed signal was filtered in the d6(7.81-15.62 Hz)band prior to and following motion events.A characteristic threshold was considered to be 40%.The accuracy of localization detection was 93%.The degree of accuracy was less than 5 mm.The present study avoided the problems of cerebral cortex injury and epilepsy onset,with an operation time of 60 seconds.Therefore,wavelet analysis on electrocorticogram is feasible for localizing cortical motor regions.Furthermore,this localization technique is accurate,safe and rapid. 展开更多
关键词 functional localization electrocorticogram mu rhythm event-related desynchronization wavelet analysis neural regeneration
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Analysis of cancer pain in hospitals in Beijing,China 认领 引用
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作者 Shikai Wu Fang Li +23 位作者 Pingping Li Jian Luo Xiaoming Wu Heling Shi Xiaohong Ning Yufei Yang Huangying Tan Ping Yang Guangqing Zhu Jianhua Zhu Guoqing Liao Huoming Chen Dapeng Lv Ye Fang Hong Dai Xiaoming Xi Xiuhua Li Yuan Qin Li Feng Su Wang Xiaoyan Chen Hongyong Wang Hongyan Li Duanqi Liu 《The Chinese-German Journal of Clinical Oncology》 2012年第6期311-316,共6页
Objective:This study aimed to survey the characteristics and treatments of cancer pain in Beijing hospitals,China.Methods:At 20:00 on December 22,2009,there conducted a questionnaire survey in 2238 patients with malig... Objective:This study aimed to survey the characteristics and treatments of cancer pain in Beijing hospitals,China.Methods:At 20:00 on December 22,2009,there conducted a questionnaire survey in 2238 patients with malignant tumors of 26 hospitals in Beijing,and the survey results were statistically analyzed.Results:The 531 cases in 2238 patients had pained and 121 cases (22.79%) had outbreak pain with one week.At 20:00 on December 22,2009,199 cases (38%) in the above-mentioned 531 pain patients suffered the moderate to severe pain (pain scores ≥ 4).The number of pain (pain scores ≥ 4) patients in the consecutive three days from December 20 to December 22 were 150.Conclusion:In the 531 cancer pain patients of the surveyed hospitals,38% of the patients were not satisfied with the pain control.Doctors believed that the main reason for pain not controlled was the non-standard treatment,but patients considered to be afraid of addiction. 展开更多
关键词 cancer pain treatment questionnaire
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Effects of V-pits covering layer position on the optoelectronic performance of InGaN green LEDs 认领 引用 被引量：5
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作者 Chen Xu Changda Zheng +4 位作者 Xiaoming Wu Shuan Pan Xingan Jiang Junlin Liu Fengyi Jiang 《Journal of Semiconductors》 CAS CSCD 2019年第5期61-65,共5页
The impact of the V-pits covering layer(VCL) position on the optoelectronic performance of InGaN-based green light-emitting diodes(LEDs) was investigated. It is found that earlier covering of V-pits will hinder the ho... The impact of the V-pits covering layer(VCL) position on the optoelectronic performance of InGaN-based green light-emitting diodes(LEDs) was investigated. It is found that earlier covering of V-pits will hinder the hole injection via the sidewall of V-pits, and then result in less quantum wells(QWs) participating in radioluminescence. The current-voltage characteristics show that the LEDs with earlier covering of V-pits have higher operating voltage at room temperature, and a more dramatic voltage rise with the reduction of temperature. Meanwhile, more manifested emission peaks for sidewall QWs and deeper QWs near to ntype layer was observed in the sample with earlier coveing of V-pits at cryogenic temperatures, for the reason that the holes being injected via V-pits sidewall have higher kinetic energy and could transport to deeper QWs. 展开更多
关键词 green light-emitting diodes V-pits covering layer hole injection efficiency operating voltage
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Dissecting the genetic architecture of glucosinolate compounds for quality improvement in flowering stalk tissues of Brassica napus 认领 引用 被引量：7
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作者 Changbin Gao Fugui Zhang +6 位作者 Yang Hu Liping Song Liguang Tang Xueli Zhang Cong'an He Aihua Wang Xiaoming Wu 《Horticultural Plant Journal》 SCIE CAS CSCD 2023年第3期553-562,共10页
Glucosinolates(GSLs) and their hydrolytic products contribute to the quality traits of rapeseed flowering stalk tissues, such as taste, flavor and anticarcinogenic properties(Glucoraphanin). However, little is known a... Glucosinolates(GSLs) and their hydrolytic products contribute to the quality traits of rapeseed flowering stalk tissues, such as taste, flavor and anticarcinogenic properties(Glucoraphanin). However, little is known about the genetic mechanisms of GSL accumulation in rapeseed flowering stalks. In this study, the variation and genetic architecture of GSL metabolites in flowering stalk tissues were investigated for the first time among a panel of 107 accessions. All GSL compounds exhibited continuous and wide variations in the present population. Progoitrin,glucobrassicanapin and gluconapin were the most abundant GSL compounds. Five quantitative trait loci(QTL) significantly associated with three GSL compounds were identified by genome-wide association study. GRA_C04 was under selected during modern breeding, in which the ratio of lower GSL haplotype(HAP2) in the accessions bred before 1990(52.56%) was significantly lower than that after 1990(78.95%). Four candidate genes, BnaA01. SOT16, BnaA06. SOT17, Bna A06. MYB51a, and Bna A06. MYB51b, were identified in the GTL_A01 and 4OH_A06 regions.These findings provide new insights into GSL biosynthesis in flowering stalk tissues and facilitate quality improvement in rapeseed flowering stalks. 展开更多
关键词 Rapeseed Brassica napus L. Glucosinolate compounds Genome-wide association study(GWAS) Flowering stalk
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Estimation of chlorophyll content in Brassica napus based on unmanned aerial vehicle images 认领 引用 被引量：5
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作者 Yayi Huang Qiming Ma +10 位作者 Xiaoming Wu Hao Li Kun Xu Gaoxiang Ji Fang Qian Lixia Li Qian Huang Ying Long Xiaojun Zhang Biyun Chen Changhua Liu 《Oil Crop Science》 CSCD 2022年第3期149-155,共7页
The chlorophyll content has a direct effect on photosynthesis of crops.In order to explore a quick and convenient method for estimating the chlorophyll content of Brassica napus and facilitate efficient crop monitorin... The chlorophyll content has a direct effect on photosynthesis of crops.In order to explore a quick and convenient method for estimating the chlorophyll content of Brassica napus and facilitate efficient crop monitoring,we measured the actual value of chlorophyll with a SPAD-502 chlorophyll detector,and collected aerial images of B.napus with an unmanned aerial vehicle(UAV)carrying a RGB camera in this study.The total number of 270samples collected images were divided into regions according to the planting conditions of different B.napus varieties in the field.Then,according to the empirical formula,there were 36 colors’characteristic parameters calculated and combined.To estimate the chlorophyll content of rape,189 samples were included in the modeling set,while the other 81 samples were enrolled in the validation set for testing the accuracy of this model.After the combination of R(red),G(green)and B(blue)color channels,the results showed that the color characteristics B/(R+G),b,B/G,(G-B)/(G+B),g-b were highly connected with the measured value of chlorophyll SPAD,and the correlation coefficient between the combination based on B/(R+G)and SPAD value was 0.747.With R2=0.805,RMSE=3.343,and RE=6.84%,the regression model created using random forest had superior outcomes,according to the model comparison.This study offers a new method for quickly estimating the amount of chlorophyll in rapeseed and a workable reference for crop monitoring using the UAV platform. 展开更多
关键词 Brassica napus Unmanned aerial vehicle Red green blue images SPAD Chlorophyll
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A preliminary report on adjuvant analgesic efficacy of HANS in opioid tolerant patients with cancer pain 认领 引用 被引量：3
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作者 Xiaomei Li Jianhua Zhu +8 位作者 Pingping Li Guangqing Zhu Xiaoming Wu Huoming Chen Huixia Zhao Wei Wang Ying Zhang Wenhua Xiao Duanqi Liu 《Chinese Journal of Cancer Research》 SCIE CAS CSCD 2014年第2期174-182,共9页
Objective： To observe the adjuvant analgesic efficacy of Han＇s Acupoint Nerve Stimulator （HANS） in opioid tolerant patients with cancer pain. Methods： A prospective non-controlled study was conducted. Opioid tole... Objective： To observe the adjuvant analgesic efficacy of Han＇s Acupoint Nerve Stimulator （HANS） in opioid tolerant patients with cancer pain. Methods： A prospective non-controlled study was conducted. Opioid tolerant patients with cancer pain were enrolled and treated with both routinely analgesics and adjuvant HANS （2/100 Hz for 30 min/d, 5 d on and 2 d off for two weeks）. Cancer pain, quality of life （QOL）, anxiety and depression were assessed before enrollment and on d 8 and d 15 with the BPI-C, EORTC QLQ-C30, and self-rating anxiety scale （SAS）/ self-rating depression scale （SDS）, respectively; the therapeutic frequency of breakthrough pain （BP） and daily opioid dose were also recorded. Results： Totally 47 patients meeting the inclusion criteria participated in this study; 43 patients completed the two-week treatment and assessment. The mean scores of patient＇s ＂worst＂ and ＂least＂ pain intensity assessed with BPI-C decreased significantly on d 8 and d 15; the therapeutic frequency of BP also significantly decreased; but the average daily dose of opioids did not change significantly. For the nine symptoms in EORTC QLQ-C30 assessment, the mean scores of pain, fatigue, constipation and insomnia were significantly lower on d 8 and d 15 compared with baseline; the mean scores of the overall health status, nausea/vomiting and the incidence rates of both anxiety and depression also decreased significantly on d 15. Conclusions： To opioid tolerant patients with cancer pain, adjuvant treatment with HANS could improve pain release and patients＇ QOL by decreasing the severity of pain, fatigue, constipation, insomnia and other concomitant symptoms; it could also decrease the incidence rates of anxiety and depression. 展开更多
关键词 Cancer pa!n opioid tolerance Han＇s Acupoint Nerve Stimulator （HANS）
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Pay attention to the rehabilitation of cancer patients—Excerpts of the 2013 NCCN Guidelines for Survivorship 认领 引用 被引量：1
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作者 Xiaoming Wu 《The Chinese-German Journal of Clinical Oncology》 2014年第5期245-247,共3页
For some survivors, the consequences of cancer are minimal; these patients can return to a normal life after the completion of treatment. In fact, a majority of cancer survivors report being in good general health and... For some survivors, the consequences of cancer are minimal; these patients can return to a normal life after the completion of treatment. In fact, a majority of cancer survivors report being in good general health and experience good to excellent quality of life. A recent review suggests that at least 50% of survivors suffer from some late effects of cancer treatment. The most common problems in cancer survivors are depression, pain, and fatigue. The guidelines suggest the following standards for survivorship care:(1) prevention of new and recurrent cancers and other late effects;(2) surveillance for cancer spread, recurrence, or second cancers;(3) assessment of late psychosocial and medical effects;(4) intervention for consequences of cancer and treatment(eg, medical problems, symptoms, psychologic distress, financial and social concerns); and(5) coordination of care between primary care providers and specialists to ensure that all of the survivor's health needs are met. The NCCN Survivorship Panel hopes that these guidelines can help both oncologic and primary health care professionals lessen the burden left on survivors by their cancer experience so they can transition back to a rewarding life. 展开更多
关键词 NCCN guidelines cancer survivor rehabilitation
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Neural Network-Based State Estimation for Nonlinear Systems With Denial-of-Service Attack Under Try-Once-Discard Protocol 认领 引用
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作者 Xueli Wang Shangwei Zhao +2 位作者 Ming Yang Xin Wang Xiaoming Wu 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第10期2182-2184,共3页
Dear Editor,This letter deals with state estimation issues of discrete-time nonlinear systems subject to denial-of-service(DoS)attacks under the try-once-discard(TOD)protocol.More specifically,to reduce the communicat... Dear Editor,This letter deals with state estimation issues of discrete-time nonlinear systems subject to denial-of-service(DoS)attacks under the try-once-discard(TOD)protocol.More specifically,to reduce the communication burden,a TOD protocol with novel update rules on protocol weights is designed for scheduling measurement outputs.In addition,unknown nonlinear functions vulnerable to DoS attacks are considered due to the openness and vulnerability of the network. 展开更多
关键词 Service DoS service
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Identi cation of seed heat tolerance and its correlation with agronomic traits in Brassica napus L. 认领 引用
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作者 Guizhen Gao Kun Xu +5 位作者 Biyun Chen Xi Cheng Guixin Yan Jiangwei Qiao Qian Huang Xiaoming Wu 《Oil Crop Science》 2018年第1期21-32,共12页
To better understand the effect of high temperature on seed viability, artificial aging treatments were implemented on 472 accessions of rapeseed (Brassica napus L.) by constant high temperature at 70℃for 8h. Results... To better understand the effect of high temperature on seed viability, artificial aging treatments were implemented on 472 accessions of rapeseed (Brassica napus L.) by constant high temperature at 70℃for 8h. Results showed a remarkable impact of constant heat on seed germination. After heat treatment, considerable variation was found in seed germinability, some genotypes even lost the ability to germinate. The effect of accelerated aging was highly significant. Germination parameters varied among ecotypes. Seed viability varied with different origin, and was significantly and positively correlated with seed yield per plant and dry weight of aboveground parts per plant among 14 agronomic traits. Germination traits were positively correlated with oil contents. 展开更多
关键词 Brassica napus L. seed viability seed germination heat stress agronomic traits yield quality
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Comparison between SSR and SNP systems of genetic diversity analysis in Brassica napus L. 认领 引用
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作者 Kun Xu Jinfeng Wu +1 位作者 Feng Li Xiaoming Wu 《Oil Crop Science》 2018年第2期86-91,共6页
Simple sequence repeat(SSR) capillary electrophoresis and single nucleotide polymorphism(SNP) array are widely used tools for investigating genetic diversity. However, efficiency between SSR and SNP on rapeseed geneti... Simple sequence repeat(SSR) capillary electrophoresis and single nucleotide polymorphism(SNP) array are widely used tools for investigating genetic diversity. However, efficiency between SSR and SNP on rapeseed genetic diversity has not been systematically assessed yet. In this study, both SSR and SNP were used on 446 worldwide B. napus germplasm lines. Data shows that 65 pairs of primers(70 SSRs) and 250 SNPs were necessary to identify the similar accessions. Furthermore, no significant differences were found between 2 systems on basic statistics, population structures, principal components and kinship parameters. In general, either SSR or SNP is efficient for genetic diversity estimation. However, our data revealed the fact that SNP array system shows slightly more accuracy than SSR system on ecotype groups division. 展开更多
关键词 SSR capillary electrophoresis SNP array genetic diversity population structure,principal component
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Mechanistic study of angiogenesis induced by shh-transfected BMMSC transplantation after myocardial infarction 认领 引用
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作者 Fenglin Song Ming Wu +6 位作者 Tao Tang Xiaoming Wu Wenwu Zhou Jin Shi Wei Zhang Zhiping Tan Jinfu Yang 《Stem Cell Discovery》 2013年第2期83-89,共7页
Objective: To investigate the changes and mechanism of angiogenesis in myocardium induced by transplantation of the sonic hedgehog (shh) gene transfected in bone marrow mesenchymal stem cells (BMMSC) after myocardial ... Objective: To investigate the changes and mechanism of angiogenesis in myocardium induced by transplantation of the sonic hedgehog (shh) gene transfected in bone marrow mesenchymal stem cells (BMMSC) after myocardial infarction. Methods: A rat model of acute myocardial infarction was made by coronary artery ligation. The rats were randomly divided into five groups of 40 rats each. These were further subdivided into groups of 10 rats. The peripheral regions of the infarcts were injected with either BMMSCSHH (transfection group), equivalent BMMSC (cell only group), BMMSC and pcDNA3.1-Shh DNA mixture (mixture group), pcDNA3.1-shh DNA alone (gene only group), or equal volumes of low-sugar DMEM medium (control group). One, two, four, and eight weeks after transplantation, specimens were harvested from the transplantation site to determine the expression of SHH signaling pathway downstream genes Ptc1, Gli-2, COUP-TF II, angiogenesis promoting factor VEGF, and Ang-1 using RT-PCR. Results: Seven days after transplantation, the expression of SHH signaling pathway downstream genes, Ptc1, Gli-2, and COUP-TF II was significantly more pronounced in the transfection group than in the control group, cell only group, gene only group, or mixture group (Ptc1: P P P < 0.05, and P COUP-TF II: P P P P Gli-2: P P P < 0.05, and P < 0.05, respectively). The expression of angiogenesis-promoting genes Vegf and Ang-1 was significantly more pronounced than in the control group, cell only group, or gene only group (Vegf: P P P Ang-1: P P P < 0.05, respectively). Conclusion: Transplantation of the shh-gene-transfected BMMSCs to the peripheral regions of myocardial infarcts promoted angiogenesis by upregulating downstream gene expression. 展开更多
关键词 Shh Bone Marrow Mesenchymal Stem Cells Ptc 1 Gli -2 COUP-TF II VEGF Ang -1
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