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Recent selection and introgression facilitated high-altitude adaptation in cattle 认领 引用 被引量：18
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作者 Yang Lyu Fuwen Wang +34 位作者 Haijian Cheng Jing Han Ruihua Dang Xiaoting Xia Hui Wang Jincheng Zhong Johannes A.Lenstra Hucai Zhang Jianlin Han David E.MacHugh Ivica Medugorac Maulik Upadhyay Alexander SLeonard He Ding Xiaorui Yang Ming-Shan Wang Suolang Quji Basang Zhuzha Pubu Quzhen Silang Wangmu Nima Cangjue Da Wa Weidong Ma Jianyong Liu Jicai Zhang Bizhi Huang Xingshan Qi Fuqiang Li Yongzhen Huang Yun Ma Yu Wang Yuanpeng Gao Wenfa Lu Chuzhao Lei Ningbo Chen 《Science Bulletin》 SCIE EI CAS CSCD 2024年第21期3415-3424,共10页
During the past 3000 years,cattle on the Qinghai-Xizang Plateau have developed adaptive phenotypes under the selective pressure of hypoxia,ultraviolet(UV)radiation,and extreme cold.The genetic mechanism underlying thi... During the past 3000 years,cattle on the Qinghai-Xizang Plateau have developed adaptive phenotypes under the selective pressure of hypoxia,ultraviolet(UV)radiation,and extreme cold.The genetic mechanism underlying this rapid adaptation is not yet well understood.Here,we present whole-genome resequencing data for 258 cattle from 32 cattle breeds/populations,including 89 Tibetan cattle representing eight populations distributed at altitudes ranging from 3400 m to 4300 m.Our genomic analysis revealed that Tibetan cattle exhibited a continuous phylogeographic cline from the East Asian taurine to the South Asian indicine ancestries.We found that recently selected genes in Tibetan cattle were related to body size(HMGA2 and NCAPG)and energy expenditure(DUOXA2).We identified signals of sympatric introgression from yak into Tibetan cattle at different altitudes,covering 0.64%–3.26%of their genomes,which included introgressed genes responsible for hypoxia response(EGLN1),cold adaptation(LRP11),DNA damage repair(LATS1),and UV radiation resistance(GNPAT).We observed that introgressed yak alleles were associated with noncoding variants,including those in present EGLN1.In Tibetan cattle,three yak introgressed SNPs in the EGLN1 promoter region reduced the expression of EGLN1,suggesting that these genomic variants enhance hypoxia tolerance.Taken together,our results indicated complex adaptation processes in Tibetan cattle,where recently selected genes and introgressed yak alleles jointly facilitated rapid adaptation to high-altitude environments. 展开更多
关键词 Tibetan cattle Introgression High-altitude adaptation Noncoding variant Cis-regulation
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Global dispersal and adaptive evolution of domestic cattle:a genomic perspective 认领 引用 被引量：6
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作者 Xiaoting Xia Kaixing Qu +8 位作者 Yan Wang Mikkel-Holger SSinding Fuwen Wang Quratulain Hanif Zulfiqar Ahmed Johannes A.Lenstra Jianlin Han Chuzhao Lei Ningbo Chen 《Stress Biology》 2023年第1期98-110,共13页
Domestic cattle have spread across the globe and inhabit variable and unpredictable environments.They have been exposed to a plethora of selective pressures and have adapted to a variety of local ecological and manage... Domestic cattle have spread across the globe and inhabit variable and unpredictable environments.They have been exposed to a plethora of selective pressures and have adapted to a variety of local ecological and management conditions,including UV exposure,diseases,and stall-feeding systems.These selective pressures have resulted in unique and important phenotypic and genetic differences among modern cattle breeds/populations.Ongoing efforts to sequence the genomes of local and commercial cattle breeds/populations,along with the growing availability of ancient bovid DNA data,have significantly advanced our understanding of the genomic architecture,recent evolution of complex traits,common diseases,and local adaptation in cattle.Here,we review the origin and spread of domestic cattle and illustrate the environmental adaptations of local cattle breeds/populations. 展开更多
关键词 Cattle Origin Domestication Migration route Environmental adaptation Selective pressure
Evolution and legacy of East Asian aurochs 认领 引用 被引量：3
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作者 Jiawen Hou Xiwen Guan +24 位作者 Xiaoting Xia Yang Lyu Xin Liu Yuri Mazei Ping Xie Fengqin Chang Xiaonan Zhang Jialei Chen Xinyi Li Fengwei Zhang Liangliang Jin Xiaoyu Luo Mikkel-Holger SSinding Xin Sun Alessandro Achilli Nicola Rambaldi Migliore Dongju Zhang Johannes ALenstra Jianlin Han Qiaomei Fu Xinyi Liu Xiaoming Zhang Ningbo Chen Chuzhao Lei Hucai Zhang 《Science Bulletin》 SCIE EI CAS CSCD 2024年第21期3425-3433,共9页
Aurochs(Bos primigenius),once widely distributed in Afro-Eurasia,became extinct in the early 1600 s.However,their phylogeography and relative contributions to domestic cattle remain unknown.In this study,we analyzed 1... Aurochs(Bos primigenius),once widely distributed in Afro-Eurasia,became extinct in the early 1600 s.However,their phylogeography and relative contributions to domestic cattle remain unknown.In this study,we analyzed 16 genomes of ancient aurochs and three mitogenomes of ancient bison(Bison priscus)excavated in East Asia,dating from 43,000 to 3,590 years ago.These newly generated data with previously published genomic information on aurochs as well as ancient/extant domestic cattle worldwide through genome analysis.Ourfindings revealed significant genetic divergence between East Asian aurochs and their European,Near Eastern,and African counterparts on the basis of both mitochondrial and nuclear genomic data.Furthermore,we identified evidence of geneflow from East Asian aurochs into ancient and present-day taurine cattle,suggesting their potential role in facilitating the environmental adaptation of domestic cattle. 展开更多
关键词 East Asian aurochs Ancient DNA Cattle domestication Adaptive introgression
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