A three-tower connected reinforced concrete(RC)frame building was selected as a prototype building and used to investigate resilience-based seismic design,aiming to provide a reference for multitower-connected buildin...A three-tower connected reinforced concrete(RC)frame building was selected as a prototype building and used to investigate resilience-based seismic design,aiming to provide a reference for multitower-connected buildings by using seismic isolation.First,a seismic resilience assessment strategy was recommended based on the characteristics of the case study.Specifically,the restoration cost index was recommended as the ratio of the total repair cost of multiple towers and connection parts with respect to the current replacement cost.In contrast,repair time and casualties were recommended as the longest repair time and the highest casualties of multiple towers due to their uncoupled functions.The influences of the critical design parameter of the isolation system(i.e.,yield ratio)on the resilient performance of the entire building was investigated.Both the repair cost and time of the building decreased at decreasing yield ratios,which were attributed to the notable control of the maximum absolute floor acceleration.Only the case study,which showed a yield ratio of 2%,achieved the highest resilience level,as regulated by the relevant Chinese code.Hence,a 2%yield ratio is recommended for the conceptual design of seismically isolated multitower-connected buildings to achieve good seismic resilience.展开更多
Furniture and equipment modeled as rocking rigid bodies within buildings are vulnerable to overturning during earthquakes,and their responses are strongly influenced by floor-level seismic amplification.However,predic...Furniture and equipment modeled as rocking rigid bodies within buildings are vulnerable to overturning during earthquakes,and their responses are strongly influenced by floor-level seismic amplification.However,predicting their seismic behavior typically involves analyses of building structural responses and rocking-body dynamics,making conventional approaches computationally expensive.Existing methods also struggle to adequately capture the nonlinear interactions among seismic motion characteristics,structural amplification effects,and the geometric properties of rocking bodies.To address this issue,this study proposes a data-driven method for predicting the seismic response of in-building rocking rigid bodies using a deep neural network(DNN).Floor seismic responses were obtained from city-scale nonlinear time-history analyses and used to calculate corresponding rocking-body responses.A multidimensional database was then established,covering various ground-motion intensity measures,building heights,and rigid-body geometries.Based on this database,a DNN model was developed for rapid overturning prediction.Results show that the proposed model achieves high computational efficiency and an accuracy of 94.37%on the test set,outperforming conventional machine learning methods.Dimensionality reduction further decreases input features and training time while preserving strong predictive performance.The proposed approach provides an efficient and intelligent framework for seismic assessment and risk analysis of rocking components in buildings.展开更多
遥感影像与地理信息系统(Geographic Information System,GIS)在水资源管理与环境保护中发挥着重要作用。通过多源遥感数据获取水体分布、水质参数和流域特征信息,结合GIS空间分析功能,实现水资源动态监测、污染源识别和生态环境评价。...遥感影像与地理信息系统(Geographic Information System,GIS)在水资源管理与环境保护中发挥着重要作用。通过多源遥感数据获取水体分布、水质参数和流域特征信息,结合GIS空间分析功能,实现水资源动态监测、污染源识别和生态环境评价。遥感影像技术提供宏观尺度的时空连续观测能力,GIS技术支撑复杂的空间建模与决策分析。两者融合应用于水资源调查评价、水环境质量监测、流域生态保护等领域,为科学制定水资源保护策略、优化配置方案和环境治理措施提供技术支撑,推动水资源可持续利用和生态环境协调发展。展开更多
The concept of seismic resilience has received significant attention from academia and industry during the last two decades. Different frameworks have been proposed for seismic resilience assessment of engineering sys...The concept of seismic resilience has received significant attention from academia and industry during the last two decades. Different frameworks have been proposed for seismic resilience assessment of engineering systems at different scales(e.g., buildings, bridges, communities, and cities). Testbeds including Centerville virtual community(CVC), Memphis testbed(MTB), and the virtual city of Turin, Italy(VC-TI) have been developed during the last decade. However, the resilience assessment results of Chinese cities still require calibration based on a unified evaluation model. Therefore, a geographic information system(GIS)-based benchmark model of a medium-sized city located in the southeastern coastal region of China was developed. The benchmark city can be used to compare existing assessment frameworks and calibrate the assessment results. The demographics, site conditions, and potential hazard exposure of the benchmark city, as well as land use and building inventory are described in this paper. Data of lifeline systems are provided, including power, transportation, water, drainage, and natural gas distribution networks, as well as the locations of hospitals, emergency shelters, and schools. Data from past earthquakes and the literature were obtained to develop seismic fragility models, consequence models, and recovery models, which can be used as basic data or calibration data in the resilience assessment process. To demonstrate the completeness of the data included in the benchmark city, a case study on the accessibility of emergency rescue after earthquakes was conducted, and the preliminary results were discussed. The ultimate goal of this benchmark city is to provide a platform for calibrating resilience assessment results and to facilitate the development of resilient cities in China.展开更多
The improvement of the seismic resilience of existing reinforced-concrete(RC) frame buildings, which is essential for the seismic resilience of a city, has become a critical issue. Although seismic isolation is an eff...The improvement of the seismic resilience of existing reinforced-concrete(RC) frame buildings, which is essential for the seismic resilience of a city, has become a critical issue. Although seismic isolation is an effective method for improving the resilient performance of such buildings, target-oriented quantitative improvements of the resilient performance of these buildings have been reported rarely. To address this gap, the seismic resilience of two existing RC frame buildings located in a high seismic intensity region of China were assessed based on the Chinese Standard for Seismic Resilience Assessment of Buildings. The critical engineering demand parameters(EDPs) affecting the seismic resilience of such buildings were identified. Subsequently, the seismic resilience of buildings retrofitted with different isolation schemes(i.e., yield ratios) were evaluated and compared, with emphasis on the relationships among yield ratios, EDPs, and levels of seismic resilience. Accordingly, to achieve the highest level of seismic resilience with respect to the Chinese standard, a yield ratio of 3% was recommended and successfully applied to the target-oriented design for the seismic-resilience improvement of an existing RC frame building. The research outcome can provide an important reference for the resilience-based retrofitting of existing RC frame buildings using seismic isolation in urban cities.展开更多
目的:采用临床研究与蛋白组学相结合的研究方法,观察益肾化湿颗粒治疗糖尿病肾病(DKD)的临床疗效并探究其作用机制。方法:选取2023年1月—2024年10月石河子大学第一附属医院就诊的DKD患者80例作为研究对象,通过随机数字表法随机分为对...目的:采用临床研究与蛋白组学相结合的研究方法,观察益肾化湿颗粒治疗糖尿病肾病(DKD)的临床疗效并探究其作用机制。方法:选取2023年1月—2024年10月石河子大学第一附属医院就诊的DKD患者80例作为研究对象,通过随机数字表法随机分为对照组和观察组各40例。对照组给予缬沙坦和达格列净治疗,观察组在此基础上给予益肾化湿颗粒治疗。经治3个月后,比较两组患者肾功能[血肌酐(SCr)、尿素氮(BUN)、胱抑素C(CysC)]水平,尿蛋白指标[24 h尿蛋白定量(24 h UP)、UACR]水平,炎症因子[C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)]水平,观察益肾化湿颗粒对DKD的临床疗效。随机从观察组中选取5名患者进行DIA尿蛋白组学分析,将服药前尿液标本定义为疾病组、用药干预3个月后尿液标本定义为干预组,另选取同期健康体检者5名作为空白组,比较干预前后患者尿蛋白表达变化,筛选出差异蛋白。结果:治疗后,对照组SCr、BUN、CysC水平较治疗前升高(P<0.05),而观察组较治疗前均下降(P<0.05);两组患者24hUP及UACR较治疗前均降低(P<0.05),且观察组均优于对照组(P<0.05);两组患者CRP、IL-6、TNF-a较治疗前均降低(P<0.05),且观察组均优于对照组(P<0.05)。通过DIA技术对各组人群尿液标本进行分析,空白组/疾病组之间筛选出1789个差异蛋白;疾病组/干预组之间筛选出173个差异蛋白。其中钙网蛋白、肝癌衍生生长因子相关蛋白2、核仁蛋白58干预后表达下调,胶原蛋白XV α1链、电压依赖性阴离子通道3、泛素结合酶E2D3干预后表达上调。针对疾病组/干预组之间差异蛋白进行KEGG通路富集,共富集得到16条差异显著的KEGG通路,其中差异最显著、富集蛋白最多的为肌动蛋白细胞骨架调控通路。结论:益肾化湿联合缬沙坦、达格列净治疗DKD,可保护肾功能,减轻尿蛋白和炎症反应。其作用机制可能通过保护足细胞滤过屏障、改善内质网应激和氧化应激、抑制上皮-间充质转化等机制减少蛋白尿,延缓DKD疾病进展。展开更多
基金National Key Technology R&D Program of China under Grant No.2022YFC3003600。
摘要A three-tower connected reinforced concrete(RC)frame building was selected as a prototype building and used to investigate resilience-based seismic design,aiming to provide a reference for multitower-connected buildings by using seismic isolation.First,a seismic resilience assessment strategy was recommended based on the characteristics of the case study.Specifically,the restoration cost index was recommended as the ratio of the total repair cost of multiple towers and connection parts with respect to the current replacement cost.In contrast,repair time and casualties were recommended as the longest repair time and the highest casualties of multiple towers due to their uncoupled functions.The influences of the critical design parameter of the isolation system(i.e.,yield ratio)on the resilient performance of the entire building was investigated.Both the repair cost and time of the building decreased at decreasing yield ratios,which were attributed to the notable control of the maximum absolute floor acceleration.Only the case study,which showed a yield ratio of 2%,achieved the highest resilience level,as regulated by the relevant Chinese code.Hence,a 2%yield ratio is recommended for the conceptual design of seismically isolated multitower-connected buildings to achieve good seismic resilience.
基金National Natural Science Foundation of China under Grant No.52308478the Scientific Research Fund of Institute of Engineering Mechanics,China Earthquake Administration under Grant No.2024D03+1 种基金the Cultivation project Funds for Beijing University of Civil Engineering and Architecture(X25023)BUCEA-BIG Joint Research Center for Hospital Construction。
摘要Furniture and equipment modeled as rocking rigid bodies within buildings are vulnerable to overturning during earthquakes,and their responses are strongly influenced by floor-level seismic amplification.However,predicting their seismic behavior typically involves analyses of building structural responses and rocking-body dynamics,making conventional approaches computationally expensive.Existing methods also struggle to adequately capture the nonlinear interactions among seismic motion characteristics,structural amplification effects,and the geometric properties of rocking bodies.To address this issue,this study proposes a data-driven method for predicting the seismic response of in-building rocking rigid bodies using a deep neural network(DNN).Floor seismic responses were obtained from city-scale nonlinear time-history analyses and used to calculate corresponding rocking-body responses.A multidimensional database was then established,covering various ground-motion intensity measures,building heights,and rigid-body geometries.Based on this database,a DNN model was developed for rapid overturning prediction.Results show that the proposed model achieves high computational efficiency and an accuracy of 94.37%on the test set,outperforming conventional machine learning methods.Dimensionality reduction further decreases input features and training time while preserving strong predictive performance.The proposed approach provides an efficient and intelligent framework for seismic assessment and risk analysis of rocking components in buildings.
摘要遥感影像与地理信息系统(Geographic Information System,GIS)在水资源管理与环境保护中发挥着重要作用。通过多源遥感数据获取水体分布、水质参数和流域特征信息,结合GIS空间分析功能,实现水资源动态监测、污染源识别和生态环境评价。遥感影像技术提供宏观尺度的时空连续观测能力,GIS技术支撑复杂的空间建模与决策分析。两者融合应用于水资源调查评价、水环境质量监测、流域生态保护等领域,为科学制定水资源保护策略、优化配置方案和环境治理措施提供技术支撑,推动水资源可持续利用和生态环境协调发展。
基金Scientific Research Fund of Institute of Engineering Mechanics,China Earthquake Administration under Grant Nos. 2019EEEVL0505,2019B02 and 2019A02Heilongjiang Touyan Innovation Team Program。
摘要The concept of seismic resilience has received significant attention from academia and industry during the last two decades. Different frameworks have been proposed for seismic resilience assessment of engineering systems at different scales(e.g., buildings, bridges, communities, and cities). Testbeds including Centerville virtual community(CVC), Memphis testbed(MTB), and the virtual city of Turin, Italy(VC-TI) have been developed during the last decade. However, the resilience assessment results of Chinese cities still require calibration based on a unified evaluation model. Therefore, a geographic information system(GIS)-based benchmark model of a medium-sized city located in the southeastern coastal region of China was developed. The benchmark city can be used to compare existing assessment frameworks and calibrate the assessment results. The demographics, site conditions, and potential hazard exposure of the benchmark city, as well as land use and building inventory are described in this paper. Data of lifeline systems are provided, including power, transportation, water, drainage, and natural gas distribution networks, as well as the locations of hospitals, emergency shelters, and schools. Data from past earthquakes and the literature were obtained to develop seismic fragility models, consequence models, and recovery models, which can be used as basic data or calibration data in the resilience assessment process. To demonstrate the completeness of the data included in the benchmark city, a case study on the accessibility of emergency rescue after earthquakes was conducted, and the preliminary results were discussed. The ultimate goal of this benchmark city is to provide a platform for calibrating resilience assessment results and to facilitate the development of resilient cities in China.
基金Beijing Natural Science Foundation under Grant No. 8192008the Scientific Research Foundation of Graduate School of Southeast University under Grant No. YBPY2021+1 种基金the Science and Technology Project of Beijing Municipal Education Commission under Grant No. KM201910016014the Program for Changjiang Scholars and Innovative Research Team in University under Grant No. IRT_17R06。
摘要The improvement of the seismic resilience of existing reinforced-concrete(RC) frame buildings, which is essential for the seismic resilience of a city, has become a critical issue. Although seismic isolation is an effective method for improving the resilient performance of such buildings, target-oriented quantitative improvements of the resilient performance of these buildings have been reported rarely. To address this gap, the seismic resilience of two existing RC frame buildings located in a high seismic intensity region of China were assessed based on the Chinese Standard for Seismic Resilience Assessment of Buildings. The critical engineering demand parameters(EDPs) affecting the seismic resilience of such buildings were identified. Subsequently, the seismic resilience of buildings retrofitted with different isolation schemes(i.e., yield ratios) were evaluated and compared, with emphasis on the relationships among yield ratios, EDPs, and levels of seismic resilience. Accordingly, to achieve the highest level of seismic resilience with respect to the Chinese standard, a yield ratio of 3% was recommended and successfully applied to the target-oriented design for the seismic-resilience improvement of an existing RC frame building. The research outcome can provide an important reference for the resilience-based retrofitting of existing RC frame buildings using seismic isolation in urban cities.
摘要目的:采用临床研究与蛋白组学相结合的研究方法,观察益肾化湿颗粒治疗糖尿病肾病(DKD)的临床疗效并探究其作用机制。方法:选取2023年1月—2024年10月石河子大学第一附属医院就诊的DKD患者80例作为研究对象,通过随机数字表法随机分为对照组和观察组各40例。对照组给予缬沙坦和达格列净治疗,观察组在此基础上给予益肾化湿颗粒治疗。经治3个月后,比较两组患者肾功能[血肌酐(SCr)、尿素氮(BUN)、胱抑素C(CysC)]水平,尿蛋白指标[24 h尿蛋白定量(24 h UP)、UACR]水平,炎症因子[C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)]水平,观察益肾化湿颗粒对DKD的临床疗效。随机从观察组中选取5名患者进行DIA尿蛋白组学分析,将服药前尿液标本定义为疾病组、用药干预3个月后尿液标本定义为干预组,另选取同期健康体检者5名作为空白组,比较干预前后患者尿蛋白表达变化,筛选出差异蛋白。结果:治疗后,对照组SCr、BUN、CysC水平较治疗前升高(P<0.05),而观察组较治疗前均下降(P<0.05);两组患者24hUP及UACR较治疗前均降低(P<0.05),且观察组均优于对照组(P<0.05);两组患者CRP、IL-6、TNF-a较治疗前均降低(P<0.05),且观察组均优于对照组(P<0.05)。通过DIA技术对各组人群尿液标本进行分析,空白组/疾病组之间筛选出1789个差异蛋白;疾病组/干预组之间筛选出173个差异蛋白。其中钙网蛋白、肝癌衍生生长因子相关蛋白2、核仁蛋白58干预后表达下调,胶原蛋白XV α1链、电压依赖性阴离子通道3、泛素结合酶E2D3干预后表达上调。针对疾病组/干预组之间差异蛋白进行KEGG通路富集,共富集得到16条差异显著的KEGG通路,其中差异最显著、富集蛋白最多的为肌动蛋白细胞骨架调控通路。结论:益肾化湿联合缬沙坦、达格列净治疗DKD,可保护肾功能,减轻尿蛋白和炎症反应。其作用机制可能通过保护足细胞滤过屏障、改善内质网应激和氧化应激、抑制上皮-间充质转化等机制减少蛋白尿,延缓DKD疾病进展。