期刊文献+
任意字段
题名或关键词
题名
关键词
摘要
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息
共找到178篇文章
< 1 2 … 9 >
每页显示 20 50 100
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
显示方式：
Clinical efficacy of Fuzheng Jiedu Xiaoyong granules in advanced colorectal cancer(spleen deficiency and stasis toxin syndrome) 认领 引用
1
作者 Hai-Yun Qin Dan Mi +4 位作者 Feng-Zhen Li Xin Hu Zheng Li Pei-Wei Cong Guo-Xin Li 《World Journal of Gastrointestinal Oncology》 SCIE 2026年第2期207-217,共11页
BACKGROUND The management of advanced colorectal cancer(CRC)is challenging due to limited treatment efficacy and the significant toxicities and resistance associated with chemotherapy.Traditional Chinese medicine offe... BACKGROUND The management of advanced colorectal cancer(CRC)is challenging due to limited treatment efficacy and the significant toxicities and resistance associated with chemotherapy.Traditional Chinese medicine offers potential therapeutic benefits through mechanisms such as inhibiting tumor proliferation,modulating immunity,and preventing angiogenesis.Fuzheng Jiedu Xiaoyong granules(FZJDXYG)has shown promising clinical results,including enhanced immune function and reduced chemotherapy-related toxicities.AIM To validate the efficacy and safety of FZJDXYG and determine its effects on immune function in patients with advanced CRC.METHODS In this multi-center,double-blind,randomized,placebo-controlled trial,78 eligible patients were randomly assigned at a ratio of 1:1 to the treatment group(receiving FZJDXYG plus standard care)or the control group(receiving placebo plus standard care)for 12 weeks.RESULTS The treatment group experienced significant reductions in carcinoembryonic antigen and carbohydrate antigen 19-9 levels(both P<0.05),with significantly greater reductions in these two markers compared to the control group(both P<0.05).Immunologically,the treatment group exhibited significant increases in CD3+and CD4+cell counts and CD4+/CD8+ratio,and decreased CD8+levels,with all changes superior to those in the control group(all P<0.05).The Karnofsky Performance Status score was also significantly higher in the treatment group(P<0.05).Crucially,the incidence of adverse events was significantly lower in the treatment group than in the control group(P<0.05).CONCLUSION FZJDXYG effectively ameliorates clinical symptoms,enhances immune function,and reduces chemotherapyinduced toxicities in patients with advanced CRC with spleen deficiency and stasis toxin syndrome. 展开更多
关键词 Advanced colorectal cancer Fuzheng Jiedu Xiaoyong granules First-line therapy Randomized controlled trial Immune function
暂未订购 下载PDF
Integrated analyses of genomic and transcriptomic data reveal candidate variants associated with carcass traits in Huaxi cattle 认领 引用 被引量：1
2
作者 Yapeng Zhang Wentao Cai +13 位作者 Qi Zhang Qian Li Yahui Wang Ruiqi Peng Haiqi Yin Xin Hu Zezhao Wang Bo Zhu Xue Gao Yan Chen Huijiang Gao Lingyang Xu Junya Li Lupei Zhang 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2025年第8期3169-3184,共16页
Cattle carcass traits are economically important in the beef industry.In the present study,we identified 184 significant genes and 822 alternative genes for 7 carcass traits using genome-wide association studies(GWAS)... Cattle carcass traits are economically important in the beef industry.In the present study,we identified 184 significant genes and 822 alternative genes for 7 carcass traits using genome-wide association studies(GWAS)in 1,566 Huaxi beef cattle.We then identified 5,860 unique cis-genes and 734 trans-genes in 227 longissimus dorsi muscle(LDM)samples to better understand the genetic regulation of gene expression.Our integration study of the GWAS and cis-eQTL analysis detected 13 variants regulating 12 identical genes,in which one variant was also detected in fine-mapping analysis.Moreover,using a transcriptome-wide association study(TWAS),we identified 4 genes(TTC30B,HMGA1,PRKD3 and FXN)that were significantly related to carcass chest depth(CCD),carcass length(CL),carcass weight(CW)and dressing percentage(DP).This study identified variants and genes that may be useful for understanding the molecular mechanism of carcass traits in beef cattle. 展开更多
关键词 beef cattle GWAS eQTL mapping fine mapping S-predixcan
暂未订购 下载PDF
Trends in Antibiotic Consumption and Antimicrobial Resistance in China:An Ecological Analysis from 2016 to 2022 认领 引用 被引量：1
3
作者 Fei Zhao Zinan Zhao +13 位作者 Di Chen Bolin Zhu Tianqi Zhang Yuanchao Zhu Xuelin Sun Liang Liang Nan Zheng Lili Zou Wenfeng Xu Sirui Guo Yue Wang Ming Zhao Xin Hu Pengfei Jin 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2026年第2期158-170,共13页
Objective To examine national trends in antibiotic consumption and antimicrobial resistance(AMR)among six WHO-priority bacterial pathogens in China from 2016 to 2022.Methods This ecological study analyzed national and... Objective To examine national trends in antibiotic consumption and antimicrobial resistance(AMR)among six WHO-priority bacterial pathogens in China from 2016 to 2022.Methods This ecological study analyzed national and provincial data from the China Antibacterial Resistance Surveillance System(CARSS)and the National Hospital Information Network.Beta regression models assessed temporal trends,and hierarchical models evaluated associations between antibiotic use and resistance.Results From 2016 to 2022,carbapenem resistance in Acinetobacter baumannii and Pseudomonas aeruginosa,and vancomycin resistance in Enterococcus faecium and E.faecalis significantly declined(β<0,P<0.010),while carbapenem-resistant Klebsiella pneumoniae increased(β=0.081,P<0.001).Nationwide antibiotic consumption rose across 10 major classes.Positive associations were found between carbapenem use and resistance in A.baumannii(z=2.719,P=0.007)and P.aeruginosa(z=3.241,P=0.001),and between vancomycin use and resistance in E.faecium(z=4.510,P=0.001)and E.faecalis(z=3.210,P=0.001).Conclusion Carbapenem-resistant K.pneumoniae increased significantly in China,while other resistant pathogens declined.Resistance patterns were linked to the use of multiple antibiotic classes,underscoring the need for strengthened antibiotic stewardship and surveillance. 展开更多
关键词 Antimicrobial resistance Carbapenem-resistant microorganisms Vancomycin-resistant enterococci Antibiotic consumption
暂未订购 下载PDF
Integrative multi-omic analysis identified ERBB2 mutations and senescence-driven immune suppression as dual therapeutic targets in LAR triple-negative breast cancer 认领 引用
4
作者 Yaxin Zhao Han Wang +3 位作者 Ying Wang Yizhou Jiang Xin Hu Zhiming Shao 《Cancer Biology & Medicine》 SCIE CAS CSCD 2026年第3期374-391,共18页
Objective:The luminal androgen receptor(LAR)subtype of triple-negative breast cancer(TNBC)differentiation displays low proliferation yet strong metastatic potential and a poor chemotherapy response.This study aimed to... Objective:The luminal androgen receptor(LAR)subtype of triple-negative breast cancer(TNBC)differentiation displays low proliferation yet strong metastatic potential and a poor chemotherapy response.This study aimed to define the molecular basis of the LAR subtype and identify actionable therapeutic targets.Methods:Comprehensive multi-omic analyses were performed on the FUSCC-TNBC cohort,integrating whole-exome sequencing,RNA sequencing,and functional validation in vitro and in vivo.Somatic mutation profiling,gene set enrichment analysis(GSEA),and weighted gene co-expression network analysis(WGCNA)were used to define genomic and transcriptomic signatures.A machine learning model using the Mime1 package was applied to derive a senescence-associated prognostic signature(LAR-S)and validation in external cohorts.Immune deconvolution was performed to decipher the tumor microenvironment.Functional assays,patient-derived organoids(PDOs),and TS/V mouse models were used to evaluate therapeutic responses to senescence-modulating agent and immunotherapy combinations.Results:The LAR subtype was enriched for PIK3CA,PTEN,and ERBB2 kinase domain mutations.Functional studies confirmed ERBB2 variants(e.g.,V777L and E698_P699delinsA)as oncogenic drivers conferring sensitivity to neratinib.Transcriptomic analyses revealed a dominant cellular senescence program associated with immune suppression.The LAR-S signature stratified survival across cohorts and predicted immunotherapy resistance.Targeting cellular senescence inhibited LAR subtype organoid growth and when combined with anti-PD-1 therapy synergistically suppressed tumor growth in vivo.Conclusions:The LAR subtype harbors two therapeutic vulnerabilities:ERBB2 mutation-driven kinase activation;and senescencemediated immune evasion.The LAR-S signature enables precise patient stratification and supports senescence-targeted and immunotherapy combination strategies as promising approaches for this refractory TNBC subtype. 展开更多
关键词 Triple-negative breast cancer luminal androgen receptor subtype ERBB2 mutation cellular senescence immunotherapy resistance
暂未订购 下载PDF
ScD27.2 gene regulation mechanism during sugarcane tillering and growth 认领 引用
5
作者 Zhuandi Wu Xin Hu +8 位作者 Wenzhi Wang Zhengying Luo Naveed ur Rehman Peifang Zhao Jiayong Liu Shuzhen Zhang Fenggang Zan Xinlong Liu Jiawen Guo 《Journal of Integrative Agriculture》 SCIE CAS CSCD 2026年第2期694-708,共15页
Tiller number represents a critical agronomic trait determining sugarcane yield.Strigolactones(SLs) are plant hormones regulating plant architecture.D27,an essential enzyme in the SL biosynthetic pathway,catalyzes a r... Tiller number represents a critical agronomic trait determining sugarcane yield.Strigolactones(SLs) are plant hormones regulating plant architecture.D27,an essential enzyme in the SL biosynthetic pathway,catalyzes a reversible isomerization reaction.ScD27.2,the D27 homolog in sugarcane,contains abiotic stress-responsive elements in its promoter,suggesting its potential importance in SL biosynthesis and stress tolerance.ScD27.2 potentially optimizes sugarcane agronomic traits,particularly tiller number and yield.Understanding its mechanisms will advance the development of high-yielding,stresstolerant sugarcane varieties.To investigate the role of D27 in sugarcane tillering,the key carotene isomerase gene ScD 27.2 was silenced(via RNAi) and overexpressed(OE) in sugarcane cultivar ‘XTT22' plantlets.ScD27-RNAi-2 sugarcane exhibited decreased ScD27.2 expression and increased tiller numbers compared to the wild type ‘XTT22'.Conversely,overexpression lines(ScD27-OE-1,ScD27-OE-5,and ScD27-OE-9) showed increased ScD27.2 expression and decreased tiller numbers.ScD27-OE-9 demonstrated notable lateral bud germination,while ScD27-RNAi-2 exhibited reduced drought tolerance.Under normal light and water management conditions,transgenic sugarcane plants showed significant differences in tiller number and plant height.During extended drought conditions,ScD27-RNAi-2 height was significantly reduced compared to wild type ‘XTT22' and ScD27-OE-9,manifesting a dwarf,multi-tiller phenotype.Additionally,ScD27-RNAi-2 showed significantly reduced SLs content.These findings demonstrate that ScD27.2 regulates tillering under drought stress,likely through SL biosynthesis,and that its drought response may be mediated by the transcription factor ScMYB44. 展开更多
关键词 DWARF27 carotene isomerase drought stress response strigolactone biosynthesis tillering
暂未订购 下载PDF
Water biofloc microorganism enhance shrimp resistance to microplastics 认领 引用
6
作者 Xin Hu Yvfei Wu +3 位作者 Yixin Tang Wenchang Liu Hongxin Tan Guozhi Luo 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2026年第6期559-571,共13页
Microorganisms play a crucial role in modifying the physical-chemical properties and ecotoxicological effects of microplastics(MPs)in aquatic ecosystems.However,existing studies have not been conducted in actual aquac... Microorganisms play a crucial role in modifying the physical-chemical properties and ecotoxicological effects of microplastics(MPs)in aquatic ecosystems.However,existing studies have not been conducted in actual aquaculture environments,which are typically enriched with a variety of microorganisms.To address this,we have investigated the potential of water biofloc to mitigate MPs contamination in Litopenaeus vannamei aquaculture systems.Here,shrimps were subjected to varying concentrations of MPs in clean water and biofloc water.Results showed that clean water group displayed significantly lower survival rate(65.28%±8.67%)and diminished immune enzymes(i.e.,lysozyme and polyphenol oxidase)activities compared to the water biofloc treatment(p<0.05).Significant differences were observed in the activities of digestive enzymes,antioxidant enzymes and Na+/K+-ATPase in the clear water and biofloc water treatments(p<0.05).Notably,biofloc treatments maintained consistent proximate composition and enzymatic activities(p<0.05),while demonstrating remarkable microbial community stability between aqueous and intestinal habitats that proved resilient to MPs exposure.However,biofloc microorganisms significantly reduced shrimp astaxanthin content(49.24%),leading to declines in pigmentation,water-holding capacity,and muscle adhesiveness.These findings offer a theoretical foundation for assessing MPs-related risks in aquaculture and advancing ecologically sustainable shrimp farming.In addition,our study provides practical insights for promoting cleaner and more sustainable aquaculture practices. 展开更多
关键词 Water biofloc Microparticle Microbiome Astaxanthin Aquaculture
暂未订购 下载PDF
Biorefinery of shrimp shell waste via black soldier fly larvae:larval performance,waste reuse efficiency,and circular economy potential 认领 引用
7
作者 Xin Hu Xinlan Lv +5 位作者 Ze Zhu Amit Gross Qinlang Liang Hongxin Tan Wenchang Liu Guozhi Luo 《ENGINEERING Environment》 SCIE EI CAS CSCD 2026年第3期95-109,共15页
The rapid expansion of shrimp farming has led to substantial accumulation of shell waste,coinciding with an increasing demand for fishmeal.Black soldier fly(Hermetia illucens)larvae(BSFL)offer an environmentally frien... The rapid expansion of shrimp farming has led to substantial accumulation of shell waste,coinciding with an increasing demand for fishmeal.Black soldier fly(Hermetia illucens)larvae(BSFL)offer an environmentally friendly solution by effectively recycling shrimp shell waste into a high-quality protein alternative for aquafeeds.This study examined the effects of shrimp shell proportions and particle sizes on the bioconversion efficiency of BSFL,accompanied by an economic analysis.The results showed that the proportion of shrimp shells,rather than their particle size,significantly influenced the bioconversion efficiency.No significant difference(p>0.05)in larval biomass yield(~120 mg/larva)was observed between substrates containing 20%-40% shrimp shell waste and wheat bran.However,larvae reared on shrimp shell-based substrates demonstrated optimal nutritional characteristics,containing 40.8%-42.4% crude protein,5.4%-6.3% chitin,and up to 103.1 g/kg calcium,along with balanced amino acid and fatty acid profiles.Notably,concentrations of undesirable elements,such as lead and cadmium,remained within acceptable feed safety limits,although strontium may pose a health risk when used in food.The optimal substrate,20%-40% shrimp shell waste with particle size<2 mm,achieved nitrogen recovery of 27.0%-37.2%,phosphorus recovery of 12.6%-18.1%,and waste reduction of 47.8%-55.4%.This study demonstrates that BSFL-based bioconversion offers a sustainable approach for managing waste from intensive shrimp farming while supporting a circular economy potential. 展开更多
关键词 Black soldier fly Waste management Protein rich biomass Health assessment Circular economy
暂未订购 下载PDF
Influence of CaO-SiO2-Al2O3-MgO slag structure on dissolution behavior of Al2O3:a molecular dynamics simulation 认领 引用
8
作者 Yi-Hong Li Ming-Ming Lu +4 位作者 Rui Wang Dong Wang Xin Hu Peng Zhang Qiang Zhu 《Journal of Iron and Steel Research International》 SCIE EI CSCD 2026年第1期110-124,共15页
The structural changes in the CaO-SiO2-Al2O3-MgO slag system with varying CaO contents were investigated through molecular dynamics(MD)simulations,and its effect on the dissolution behavior of alumina inclusi... The structural changes in the CaO-SiO2-Al2O3-MgO slag system with varying CaO contents were investigated through molecular dynamics(MD)simulations,and its effect on the dissolution behavior of alumina inclusions was characterized by the Kullback-Leibler(KL)divergence.The slag structure analysis revealed that the[AlO]tetrahedral structure was the primary network structure in the slag.With increasing the CaO content,the non-bridge oxygen(NBO)content in the slag structure increases,and the bridge oxygen(BO)content decreases,thereby reducing the complexity of the slag network structure.Raman spectroscopy detection verifies the results of the MD simulations.The results indicated that the dissolution rate of alumina inclusions accelerates with increasing the CaO content in the slag,owing to the reduced complexity of the slag network structure and the enhanced interatomic interactions.The simulation results for the dissolution of alumina inclusions were consistent with theoretical calculations based on the slag inclusion capacity and the dimensionless dissolution rate of inclusions.Radial distribution function analysis demonstrated that the interaction between atoms in the slag system and alumina inclusions strengthens,increasing the dissolution rate of alumina inclusions.The[AlO6]octahedral structure of the alumina inclusions is disrupted,forming BO structures,which in turn enhances the complexity of the slag network structure,slowing the dissolution rate of alumina inclusions.In contrast,the slag system with a higher CaO content has a relatively simpler network structure,promoting faster alumina inclusion dissolution. 展开更多
关键词 Molecular dynamics simulation Slag structure Dissolution behaviour Alumina inclusion Dissolution rate
暂未订购 下载PDF
SlWRKY80 and SlWRKY81 synergistically regulate the autophagy gene SlATG13b to actively resist saline-alkali stress in tomato 认领 引用
9
作者 Chunyu Shang Guo Chen +12 位作者 Xianjue Ruan Xiaoyan Liu Dan Du Xin Hu Zhenglun Li Qingyuan Li Xinchen Niu Dongdong Gao Silong Li Abid Khan Jinhua Li Yu Pan Xiaohui hu 《Horticultural Plant Journal》 SCIE CAS CSCD 2026年第4期905-917,共13页
Saline-alkali stress is a significant abiotic stressor that affects the growth of tomato(Solanum lycopersicum L.).Our previous studies reported that the homologous genes SIWRKY80 and SIWRKY81 can both resist saline-al... Saline-alkali stress is a significant abiotic stressor that affects the growth of tomato(Solanum lycopersicum L.).Our previous studies reported that the homologous genes SIWRKY80 and SIWRKY81 can both resist saline-alkali stress by mediating the JA pathway.In this study,the cooverexpressing(SOE)and co-silencing(SQ)lines of SlWRKY80 and SIWRKY81 to saline-alkali treatment,and the results showed that SOE line had significantly higher morphological indices,physiological indices,and endogenous JA and MeJA contents than the WT,while SQ line was opposite.In addition,the SOE line showed a significant increase in autophagy against saline-alkali stress,and both SlWRKY80 and SlWRKY81 were positively regulating the transcription of the autophagy gene SIATG13b as screened and verified by transcriptome screening,qRT-PCR,WB(Western Blot),Y1H(Yeast One-Hybrid),ChIP-qPCR,EMSA(Electrophoretic Mobility Shift Assay),and D-LUC(D-Luciferin Experiment),and also had a synergistic effect in activating SIATG13b.The growth and physiological indexes of VIGS-SIATG13b line were significantly lower than those of other groups,and pro-SlATG13b is significantly activated by MeJA and saline-alkali signals,so the SIATG13b was regulating the resistance of tomato to saline-alkali stress.In summary,the increase of endogenous JA and MeJA content in tomato after saline-alkali stress inhibited the expression and synthesis of SIJAZ1,activated the transcription and protein synthesis of SlWRKY80 and SlWRKY81,and SlWRKY80 and SlWRKY81 coordinately regulated the transcription of SlATG13b,which resulted in the production of more autophagosomes and enhanced the resistance of tomato to saline-alkali stress.This study further improved the molecular mechanism of SlWRKY80 and SIWRKY81 mediating the JA pathway against saline-alkali stress,and laid a solid theoretical foundation for tomato saline-alkali resistance breeding. 展开更多
关键词 SlWRKY80 SlWRKY81 SlATG13b Autophagy Saline-alkali stress
暂未订购 下载PDF
Endogenous/Exogenous Dual-Responsive Bimetallic Hollow Nanozyme for Photothermal/Nanocatalysis/Immune Synergistic Tumor Therapy 认领 引用
10
作者 Nan-Nan Zheng Xin Hu Jun-Qing Hu 《Rare Metals》 SCIE EI CAS CSCD 2026年第1期380-391,共12页
Nanozymes have attracted considerable attention in cancer therapy due to their adjustable enzyme activity and high catalytic efficiency.However,they still face a major challenge from tumor metastasis.In this work,endo... Nanozymes have attracted considerable attention in cancer therapy due to their adjustable enzyme activity and high catalytic efficiency.However,they still face a major challenge from tumor metastasis.In this work,endogenous/exogenous dualresponsive bimetallic hollow PdRu(termed HPdRu) nanozymes were prepared.They respond to the tumor microenvironment with weak acidity and overexpressed hydrogen peroxide(H2O2),producing large amounts of reactive oxygen species(ROS),including hydroxyl radicals(·OH) and superoxide anions(·O2-).These ROS cause mitochondrial damage and achieve specific nanocatalysis therapy(NCT).Under near-infrared(NIR) light irradiation,the HPdRu nanozymes exhibit remarkable photothermal conversion ability(48.7%).Heat ablation from NIR light-mediated photothermal therapy(PTT) and eruptible ROS jointly trigger tumor cell apoptosis.The tumor suppression rate reaches as high as 95%.Moreover,NCT and PTT induce immunogenic cell death through the release of damage-associated molecular patterns,which stimulate dendritic cell maturation and T lymphocyte activation,thereby inhibiting tumor metastasis.Overall,the bimetallic nanozymes establish an efficient anticancer model through the combined action of NCT,PTT,and immunomodulation,offering new perspectives for malignant tumor treatment. 展开更多
关键词 bimetallic nanozyme hollow structure immunogenic cell death nanocatalysis therapy photothermal therapy
暂未订购 下载PDF
High-Performance Wide-Temperature Zinc-Ion Batteries with K+/C3N4Co-Intercalated Ammonium Vanadate Cathodes 认领 引用
11
作者 Daming Chen Jimin Fu +11 位作者 Yang Ming Wei Cai Yidi Wang Xin Hu Rujun Yu Ming Yang Yixin Hu Benjamin Tawiah Shuo Shi Hanbai Wu Zijian Li Bin Fei 《Nano-Micro Letters》 SCIE EI CAS CSCD 2026年第2期320-336,共17页
NH4V4O10(NVO)is considered a promising cathode material for aqueous zinc-ion batteries due to its high theoretical capacity.However,its practical application is limited by irreversible deamination,structural ... NH4V4O10(NVO)is considered a promising cathode material for aqueous zinc-ion batteries due to its high theoretical capacity.However,its practical application is limited by irreversible deamination,structural collapse,and sluggish reaction kinetics during cycling.Herein,K+and C3N4co-intercalated NVO(KNVO-C3N4)nanosheets with expanded interlayer spacing are synthesized for the first time to achieve high-rate,stable,and wide-temperature cathodes.Molecular dynamics and experimental results confirm that there is an optimal C3N4content to achieve higher reaction kinetics.The synergistic effect of K+and C3N4co-intercalation significantly reduces the electrostatic interaction between Zn2+and the[VOn]layer,improves the specific capacity and cycling stability.Consequently,the KNVO-C3N4electrode displays outstanding electrochemical performance at room temperature and under extreme environments.It exhibits excellent rate performance(228.4 m Ah g-1at 20 A g-1),long-term cycling stability(174.2 m Ah g-1 after 10,000 cycles at 20 A g-1),and power/energy density(210.0 Wh kg-1at 14,200 W kg-1)at room temperature.Notably,it shows remarkable storage performance at-20℃(111.3 m Ah g-1at 20 A g-1)and 60℃(208.6 m Ah g-1at 20 A g-1).This strategy offers a novel approach to developing high-performance cathodes capable of operating under extreme temperatures. 展开更多
关键词 K+and C3N4co-intercalation Synergistic effect Reaction kinetics Extreme environments Aqueous zinc-ion batteries
暂未订购 下载PDF
Facies-controlled prediction of dolomite reservoirs in the Middle Permian Qixia Formation in Shuangyushi,northwestern Sichuan Basin 认领 引用
12
作者 Chao Zheng Benjian Zhang +11 位作者 Rongrong Li Hong Yin Yufeng Wang Xin Hu Xiao Chen Ran Liu Qi Zeng Zhiyun Sun Rui Zhang Xingyu Zhang Weidong Yin Kun Zhang 《Energy Geoscience》 EI 2024年第2期21-30,共10页
The Middle Permian Qixia Formation in the Shuangyushi area,northwestern Sichuan Basin,develops shoal-facies dolomite reservoirs.To pinpoint promising reservoirs in the Qixia Formation,deep thin shoal-facies dolomite r... The Middle Permian Qixia Formation in the Shuangyushi area,northwestern Sichuan Basin,develops shoal-facies dolomite reservoirs.To pinpoint promising reservoirs in the Qixia Formation,deep thin shoal-facies dolomite reservoirs were predicted using the techniques of pre-stack Kirchhoff-Q compensation for absorption,inverse Q filtering,low-to high-frequency compensation,forward modeling,and facies-controlled seismic meme inversion.The results are obtained in six aspects.First,the dolomite reservoirs mainly exist in the middle and lower parts of the second member of Qixia Formation(Qi2 Member),which coincide with the zones shoal cores are developed.Second,the forward modeling shows that the trough energy at the top and bottom of shoal core increases with increasing shoal-core thickness,and weak peak reflections are associated in the middle of shoal core.Third,five types of seismic waveform are identified through waveform analysis of seismic facies.Type-Ⅰ and Type-Ⅱ waveforms correspond to promising facies(shoal core microfacies).Fourth,vertically,two packages of thin dolomite reservoirs turn up in the sedimentary cycle of intraplatform shoal in the Qi2 Member,and the lower package is superior to the upper package in dolomite thickness,scale and lateral connectivity.Fifth,in plane,significantly controlled by sedimentary facies,dolomite reservoirs laterally distribute with consistent thickness in shoal cores at topographical highs and extend toward the break.Sixth,the promising prospects are the zones with thick dolomite reservoirs and superimposition of horstegraben structural traps. 展开更多
关键词 Reservoir prediction Seismic facies Shoal-facies dolomite Qixia formation Shuangyushi Sichuan basin
暂未订购 下载PDF
Predictive value of serum inflammatory factors combined with ptau181 for anxiety and depression in Alzheimer’s disease patients 认领 引用
13
作者 Xin Hu Jin Tao +1 位作者 Yun-Li Jiang Kai Liu 《World Journal of Psychiatry》 SCIE 2026年第8期315-326,共12页
BACKGROUND Comorbid anxiety and depression are common among patients with Alzheimer’s disease(AD),significantly impacting these individuals’disease trajectory and quality of life.Serum inflammatory markers and phosp... BACKGROUND Comorbid anxiety and depression are common among patients with Alzheimer’s disease(AD),significantly impacting these individuals’disease trajectory and quality of life.Serum inflammatory markers and phosphorylated tau protein appear to be key predictors of these psychiatric disturbances emerging in our population of AD patients,although the mechanisms governing their combined predictive capacity have yet to be determined.AIM To examine the predictive effects of p-tau181 and serum inflammatory markers[interleukin-6(IL-6),tumor necrosis factor alpha(TNF-α)]on anxiety and depression in AD patients.METHODS Retrospective data were collected from 125 patients diagnosed with AD,who were admitted to the neurology department of our center from January 2022 to December 2024.Based on the results of Hospital Anxiety and Depression Scale(HADS)anxiety and depression status,patients were stratified into two groups:Anxiety-depression group(HADS-A≥8 or HADS-D≥8,n=56),and non-anxiety depression group(HADS-A<8 and HADS-D<8,n=69).The concentrations of serum IL-6,TNF-αand plasma ptau181 were measured using enzyme-linked immunosorbent assay and single-molecule array technology.Receiver operating characteristic curve analysis and logistic regression were conducted to assess the predictive capacity of these biomarkers in anxiety and depression.RESULTS The study population included 125 AD patients(mean age 72.8±8.6 years,males:Females ratio of 44.8%:55.2%).Out of the 125 patients,anxiety and/or depression developed in 56(44.8%)during the observation period.The anxiety-depression group(n=56)had significantly increased serum IL-6 levels(15.8±4.2 pg/mL vs 9.6±3.1 pg/mL,P<0.001),TNF-αlevels(28.4±6.8 pg/mL vs 18.2±5.4 pg/mL,P<0.001)and p-tau181 concentrations(24.6±5.8 pg/mL vs 16.4±4.2 pg/mL,P<0.001)compared with non-anxiety-depression group(n=69).From multivariate logistic regression,three independent risk factors were identified:Increased IL-6[odds ratio(OR)=2.86,95%confidence interval(CI):1.42-5.76,P=0.003],increased TNF-α(OR=2.54,95%CI:1.28-5.04,P=0.008)and increased p-tau181(OR=3.12,95%CI:1.56-6.24,P=0.001).Overall prediction model performance was excellent(area under curve=0.892,95%CI:0.834-0.950)with sensitivity of 82.1%and specificity of 85.5%,far better than that for predictors on an individual biomarker basis(P<0.001).CONCLUSION We found that the combination of serum inflammatory markers(IL-6,TNF-α)as well as p-tau181 showed excellent predictive for anxiety and depression on AD patients.Conclusion:This multimarker panel shows promising preliminary predictive performance for identifying AD patients at higher risk for anxiety and depression;however,these findings are hypothesis-generating and require prospective external validation in multicenter cohorts before clinical implementation. 展开更多
关键词 Alzheimer disease Anxiety Depression Interleukin-6 Tumor necrosis factor-alpha Phosphorylated tau Biomarkers Retrospective study
暂未订购 下载PDF
Characterization and stability of sedimentary colloids in different ecology regions in Taihu Lake 认领 引用 被引量：2
14
作者 Xin HU Jing LI +5 位作者 Juan WANG Li YIN Kaipian SHI Heyong HUANG Yong ZHANG Shiyin LI 《Journal of Oceanology and Limnology》 SCIE CAS CSCD 2023年第6期2146-2159,共14页
Colloidal particles,heterogeneous mixture with various organic components and continuous molecular weight(MW)distribution,is omnipresent in lake sediments and substantially influence the retention,transportation,and f... Colloidal particles,heterogeneous mixture with various organic components and continuous molecular weight(MW)distribution,is omnipresent in lake sediments and substantially influence the retention,transportation,and fate of contaminants in lake ecosystem.We sampled and extracted sedimentary colloids from different ecology regions in Taihu Lake,Jiangsu,East China,in June 2020,and they were further separated into four different particle size ranges by tangent ultrafiltration,and the properties of colloids were studied in various methods,including zeta potential analysis,transmission electron micrograph images(TEM),Fourier transformation infrared(FTIR),and 3D fluorescence.Results show that the surface of the colloids is covered with organic macromolecular substances,such as humuslike substances and protein-like substances.There were significant differences in molecular weight and fraction content of colloids in the sediments from macrophyte-dominant(MD)area and algae-dominant(AD)area in the lake.Colloids from MD area are mainly composed of humic acid,protein,and fulvic acid;the content of fulvic acid is lower than that of humic acid and protein.The humic acid exists mainly in small molecular weight(10-100 kDa),protein exists in mainly large molecular weight colloids(0.45-1μm).Colloids from AD area are mainly composed of humic acid,and mainly distributed in the molecular weight(10 kDa-0.45μm).The presence of humic acid inhibits effectively the agglomeration of the colloids.Especially,the stability of colloids is closely related to the molecular weight,with low molecular weight from MD area show higher stability.The existence of humic acid in colloids increases the electrostatic repulsion between colloidal particles,which can effectively inhibit the agglomeration of colloids,thus enhancing the stability of colloids.Furthermore,both monovalent and divalent electrolytes enhance colloidal aggregation,and the low-molecular-weight(LMW)colloid fraction exhibits higher stability efficiency than the high-molecular-weight(HMW)colloidal. 展开更多
关键词 sediment colloid molecular weight electrolyte ion characterization aggregation behavior
暂未订购 下载PDF
Research on the Construction of Digital Collaborative Mechanism for New Villagers’Participation in Rural Governance Under the Background of Rural Revitalization 认领 引用
15
作者 Jinyun Yang Xin Hu 《Proceedings of Business and Economic Studies》 2026年第2期183-189,共7页
Against the backdrop of the full implementation of the rural revitalization strategy,achieving effective governance serves as a pivotal measure to consolidate the achievements of poverty alleviation and advance the mo... Against the backdrop of the full implementation of the rural revitalization strategy,achieving effective governance serves as a pivotal measure to consolidate the achievements of poverty alleviation and advance the modernization of agriculture and rural areas.China boasts a profound accumulation of township sage culture,which provides valuable resources for enhancing the efficiency of rural governance,while the empowerment of digital technology acts as a driving force for rural development.However,there currently exists several issues in the digital collaboration between the participation of new township sages in rural governance and rural digitalization,such as ambiguous identity positioning,unsmooth communication channels,and inefficient resource integration,stemming from the lack of a normalized communication mechanism and the lag in technological empowerment.This study focuses on the construction of a digital collaboration mechanism,aiming to explore how to utilize digital tools to build a digital collaboration platform for new township sages’participation in rural governance.This research seeks to expand the breadth,depth and effectiveness of their participation,create a smooth and sustainable governance environment,and stimulate the driving force for rural revitalization. 展开更多
关键词 Rural revitalization New township sages Digital collaboration
暂未订购 下载PDF
No-touch recipient hepatectomy in liver transplantation for liver malignancies: A state-of-the-art review 认领 引用 被引量：2
16
作者 Sheng-Jun Xu Qiang Wei +4 位作者 Xin Hu Chang-Biao Li Zhe Yang Shu-Sen Zheng Xiao Xu 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2025年第1期39-44,共6页
Tumor recurrence, the Gordian knot of liver transplantation for malignancies, may be attributed to many parameters. The technique of the “classical” recipient hepatectomy is believed to be one of the potential reaso... Tumor recurrence, the Gordian knot of liver transplantation for malignancies, may be attributed to many parameters. The technique of the “classical” recipient hepatectomy is believed to be one of the potential reasons to cause tumor evasion because of the possible increase of circulating tumor cells, thus leading to an increased recurrent rate. On this background, the no-touch oncological recipient hepatectomy technique has been developed. A comprehensive review of the development and the key surgical steps of the no-touch recipient hepatectomy is presented. This technique might improve clinical outcomes, especially for those recipients who are at a high risk for tumor recurrence. Multicenter prospective studies should be set up to further validate the prognostic role of this technique in patients with liver cancer treated with liver transplantation. 展开更多
关键词 Liver transplantation Hepatocellular cancer Tumor recurrence Surgical technique No-touch recipient hepatectomy Vena cave sparing hepatectomy
暂未订购 下载PDF
Comprehensive characterization of lncRNA N6-methyladenosine modification dynamics throughout bovine skeletal muscle development 认领 引用 被引量：2
17
作者 Cui Mao Wei You +4 位作者 Yuta Yang Haijian Cheng Xin Hu Xianyong Lan Enliang Song 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2025年第3期1025-1040,共16页
Background N6-methyladenosine(m6A)methylation is a key epigenetic modification that can modulate gene expression and strongly affect mammalian developmental processes.However,the genome-wide methylation of long ... Background N6-methyladenosine(m6A)methylation is a key epigenetic modification that can modulate gene expression and strongly affect mammalian developmental processes.However,the genome-wide methylation of long non-coding RNAs(lncRNAs)and its implications for the development of skeletal muscle remain poorly understood.Bovine skeletal muscle samples from five developmental stages were analyzed in this study to establish lncRNA methylome and transcriptomic maps.Results Globally,59.67%of lncRNAs in skeletal muscle with m6A modifications,and this percentage decreased progressively during development.lncRNA expression levels were positively associated with the number of m6A peaks,with lncRNAs possessing 3 or more peaks showing significantly higher expression levels than those with 1 or 2 peaks.Specific lncRNAs involved in skeletal muscle development were identified through two analytical approaches.The first approach employed weighted gene co-expression network analysis(WGCNA)of transcriptomic data to identify correlations between annotated lncRNAs and growth-related traits,resulting in 21 candidate hub lncRNAs.The intersection of these 21 hub lncRNAs with 151 differentially methylated lncRNAs(DM-lncRNAs)identified 10 shared candidate lncRNAs.The second approach integrated MeRIP-seq and RNA-seq data to identify 36 lncRNAs that were both differentially m6A modified and differentially expressed(dme-lncRNAs).GO and KEGG enrichment analyses of cis-target genes associated with these dme-lncRNAs identified eight candidate lncRNAs.Combining the results from the two approaches identified 16 key m6A-modified lncRNAs likely involved in skeletal muscle development.Conclusions These findings highlight the regulatory and functional significance of dynamic lncRNA methylation in skeletal muscle development. 展开更多
关键词 Bovine LncRNA m6A methylation Muscle development
暂未订购 下载PDF
Comprehensive multi-omics analysis of nutrient dynamics in colored wheat provides novel insights into the development of functional foods 认领 引用 被引量：2
18
作者 Taotao Shi Xin Hu +5 位作者 Xinyi Wang Min Ao Yueqi Zhang Fangdi Li Wenhao Yan Wei Chen 《Seed Biology》 2025年第1期213-222,共10页
Studying the nutritional components and accumulation patterns in colored wheat grains is essential for improving wheat nutritional quality and advancing the development of functional foods.Through a comprehensive high... Studying the nutritional components and accumulation patterns in colored wheat grains is essential for improving wheat nutritional quality and advancing the development of functional foods.Through a comprehensive high-throughput metabolomics and ionomics analysis of grains from 16 colored wheat varieties at various growth stages,501 essential nutrients were identified.The findings revealed that colored wheat exhibited higher levels of anthocyanins,vitamins,iron,and zinc compared to white wheat.Anthocyanin levels increased in colored wheat varieties post-21 d after flowering,while other nutrients decreased as the grains matured.Interestingly,green wheat kernels were found to be more nutrient-rich than mature kernels,containing beneficial compounds such as polyphenols,flavonoids,amino acids,and vitamins,which make them ideal for functional food development.Transcriptome analysis identified key synthetic genes and transcription factors responsible for anthocyanidin accumulation in colored wheat.This study offers valuable insights for utilizing colored wheat varieties to improve crop nutrition and innovate in the field of functional foods. 展开更多
关键词 nutrient dynamics improving wheat nutritional quality ionomics colored wheat nutritional components metabolomics ionomics analysis functional foods
暂未订购 下载PDF
circ0006646 serves as a robust prognostic biomarker for post-transplant tumor recurrence and survival in hepatocellular carcinoma patients 认领 引用 被引量：1
19
作者 Rong-Gao Chen Guan-Rong Chen +7 位作者 Xiao-Xiao Jiang Ying-Chen Huang Xin Hu Wei-Liang Xia Qi-Yang Cheng Kun Wang Xiao Xu Shu-Sen Zheng 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2025年第6期616-624,共9页
Background:Tumor recurrence severely impacts the prognosis of hepatocellular carcinoma(HCC)patients undergoing liver transplantation(LT).We aimed to explore novel and robust biomarkers for precise prediction of tumor ... Background:Tumor recurrence severely impacts the prognosis of hepatocellular carcinoma(HCC)patients undergoing liver transplantation(LT).We aimed to explore novel and robust biomarkers for precise prediction of tumor recurrence and prognosis following LT.Methods:Cancerous tissues of 252 HCC patients who underwent LT across three centers were included in the study.Tissue microarrays and in situ hybridization were utilized to assess the circ0006646 level.Kaplan-Meier method along with the log-rank test was performed to analyze overall survival and recurrence-free survival.To identify prognostic factors,particularly related to tumor recurrence,we conducted univariate and multivariate Cox regression analyses.Nomogram was constructed to predict the risk of tumor recurrence after LT and subsequently the efficacy of the nomogram was validated.Results:Elevated circ0006646 levels in HCC were associated with reduced survival and increased recurrence rates following LT(5-year overall survival:29.2%vs.60.4%,P<0.01;5-year recurrence-free survival:42.3%vs.63.0%,P<0.001).High circ0006646 expression was significantly correlated with higher Child-Pugh grade(P=0.040),larger total tumor diameter(P=0.033),and beyond the Milan criteria(P=0.033).Cox regression analysis unveiled that circ0006646 expression score,preoperative transarterial chemoembolization(TACE),positive HBsAg status,poor tumor differentiation and beyond the Hangzhou criteria were independent risk factors for post-transplant tumor recurrence,leading to the development of a novel nomogram for precise prediction.The nomogram demonstrated a reasonable prognostic effectiveness(area under the receiver operating characteristic curve=0.7636,C-index=0.745)and outperformed conventional models like the Milan criteria.Besides,the inclusion of circ0006646 enhanced the precision of the Milan and Hangzhou criteria.Moreover,circ0006646 served as a potent biomarker in alpha-fetoprotein(AFP)-negative HCC undergoing LT.Conclusions:circ0006646 is a novel and robust prognostic biomarker for predicting post-transplant survival and tumor recurrence in HCC patients.A nomogram integrating circ0006646 stands as a valuable prognostic instrument in LT for HCC. 展开更多
关键词 circ0006646 Hepatocellular carcinoma Liver transplantation Tumor recurrence Nomogram
暂未订购 下载PDF
Flotation properties and separation mechanism of ammonium dodecylsulfate on lepidolite minerals 认领 引用 被引量：1
20
作者 Xin Hu Xian-Ping Luo +5 位作者 Zi-Shuai Liu He-Peng Zhou Xue-Kun Tang Hui-Yang Lin Lu-Shuai Yao Wan-Ting Bai 《Rare Metals》 SCIE EI CAS CSCD 2025年第4期2791-2804,共14页
Lepidolite,feldspar,and quartz are silicate minerals with similar chemical properties,complicating their flotation separation.Current collector systems require strong acidic conditions for effective separation but sti... Lepidolite,feldspar,and quartz are silicate minerals with similar chemical properties,complicating their flotation separation.Current collector systems require strong acidic conditions for effective separation but still face challenges related to low separation efficiency and recovery rates.This study proposed a novel collector,ammonium dodecylsulfate(ALS),to selectively extract lepidolite from feldspar and quartz using highly selective flotation methods.Microflotation experiments showed that ALS significantly outperforms other collectors in collecting lepidolite compared to feldspar and quartz.At pH 7,lepidolite recovery reached 95%,while flotation recoveries for both feldspar and quartz were below 10%.Mixed pure mineral flotation tests revealed that at pH 7 and ALS concentration of 2.5×10-4 mol·L−1,the Li2O content in the concentrate was 4.21%,with a recovery rate of 95.01%.Separation efficiency and Gaudin selectivity index values were recorded.Solution chemical analyses showed that at pH 7,ALS completely ionizes into NH4+and CH3(CH2)11OSO3−.Various analytical techniques,including high-speed photography imaging,contact angle measurements,Fourier transform infrared spectroscopy,zeta potential analysis,and X-ray photoelectron spectroscopy,confirmed that the anion CH3(CH2)11OSO3−adsorbs chemically onto aluminum sites on lepidolite's surface,while the cation NH4+binds through electrostatic interactions and hydrogen bonding.The combined adsorption of these ions on lepidolite's surface enhanced its hydrophobicity.In contrast,ALS showed minimal adsorption on feldspar and quartz surfaces,which remained hydrophilic,enabling efficient selective flotation separation of lepidolite from both feldspar and quartz. 展开更多
关键词 Lepidolite Collector Flotation separation Ammonium dodecylsulphate Feldspar and quartz
暂未订购 下载PDF
已选0条
引用分析
参考文献
引证文献
 统计分析
检索结果
已选文献
上一页 1 2 … 9 下一页 到第 页
在线咨询 使用帮助 返回顶部 意见反馈