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Mechanistic insights into the strength and slaking resistance enhancement of biocemented sand through xanthan gum-assisted CaCO3 nucleation 认领 引用
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作者 Sai ZHANG Jianwen DING +2 位作者 Shoujie WANG Kexiang ZHANG Xinrui ZHANG 《ENGINEERING Structure and Civil Engineering》 SCIE EI CAS CSCD 2026年第4期674-689,共16页
To address the limited reinforcement efficiency of enzyme-induced calcium carbonate precipitation(EICP)caused by insufficient nucleation sites,this study introduces xanthan gum(XG)to immobilize the enzyme and promote ... To address the limited reinforcement efficiency of enzyme-induced calcium carbonate precipitation(EICP)caused by insufficient nucleation sites,this study introduces xanthan gum(XG)to immobilize the enzyme and promote the CaCO3 nucleation.A series of unconfined compressive strength(UCS)tests and ultrasonic oscillation tests were conducted to evaluate the effects of XG on the mechanical behavior and slaking resistance of biocemented sand.The nucleation and cementation mechanisms of XG addition were clarified through scanning electron microscopy with energy-dispersive spectroscopy and X-ray diffraction.The results demonstrate that as the XG concentration increased from 0 to 2 g/L,the UCS increases from 121.10 to 231.05 kPa,showing an increase of 90.8%.At the same time,the average slaking index decreases from 2.588 to 1.323.The enhancement is attributed to the increased viscosity of the enzyme solution with XG addition,which improves solution retention in low-energy sites.In addition,the negatively charged carboxylate groups on XG enhance Ca2+adsorption,creating more nucleation sites and promoting targeted precipitation of CaCO3 at particle contact points and interfaces.This study confirms that biopolymer-assisted nucleation can improve both the strength and slaking resistance of biocemented sand,providing a basis for promoting biocementation technologies in applications such as erosion control and hydrological engineering. 展开更多
关键词 EICP XG strength slaking resistance microscopic mechanism
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A microfluidic biosensor based on multiple signal amplification for rapid and sensitive detection of E.coli O157:H7 and Staphylococcus aureus 认领 引用
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作者 Xinrui Zhang Hui Chen +3 位作者 Tingting Fan Xueming Zhu Ying Tan Dan Gao 《Chinese Chemical Letters》 SCIE CAS CSCD 2026年第4期694-699,共6页
E.coli O157:H7 and Staphylococcus aureus have emerged as significant foodborne pathogens,characterized by considerable incidence rates and mortality.Despite advancements,current detection methods are hindered by chall... E.coli O157:H7 and Staphylococcus aureus have emerged as significant foodborne pathogens,characterized by considerable incidence rates and mortality.Despite advancements,current detection methods are hindered by challenges in enhancing specificity and sensitivity.Herein,we introduced a cutting-edge biosensor that employs a novel CHA-coupled CRISPR multi-stage signal amplification technique for the rapid and ultra-sensitive detection of these two pathogens.This microfluidic device consisted of an upstream serpentine mixing channel and a downstream boat-shaped microcavity equipped with a microcolumn array,facilitating efficient reagent mixing,robust CHA amplification,and CRISPR reactions.Multiple signal amplification was achieved through bacterial competitive binding triggered by catalytic hairpin assembly(CHA)and cr RNA-mediated CRISPR reactions.Based on this platform,the detection of target bacteria is transformed into nucleic acid detection,with a maximum detection range of 134 CFU/mL for E.coli O157:H7 and 181 CFU/mL for Staphylococcus aureus,which were better or comparable to previously reported biosensors.The entire assay was completed within approximately 1.5 h,with a minimal sample volume requirement of just 10μL.The biosensor exhibited a high recovery rate,ranging from 95%to 115%,and demonstrated excellent specificity towards the target bacteria.In summary,this biosensor offers a rapid,accurate,and highly sensitive tool for food safety and clinical diagnostics. 展开更多
关键词 Microfluidic chip Catalytic hairpin assembly CRISPR Staphylococcus aureus E.coli O157:H7
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High-performance PEEK for 4D printing by confining the PEEK powder within photocurable polymer network 认领 引用
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作者 Yuanbin Mao Junhui Gong +5 位作者 ZhangZhang Tang Xinrui Zhang Xianqiang Pei Jianming Li Qihua Wang Yaoming Zhang 《Additive Manufacturing Frontiers》 CAS CSCD 2026年第1期302-311,共10页
Poly(ether-ether-ketone)(PEEK)is widely used in aerospace applications as a self-lubricating material owing to its exceptional mechanical strength and thermal stability.Although fused deposition modeling(FDM)3D printi... Poly(ether-ether-ketone)(PEEK)is widely used in aerospace applications as a self-lubricating material owing to its exceptional mechanical strength and thermal stability.Although fused deposition modeling(FDM)3D printing is commonly employed for PEEK fabrication,the precise printing of complex and intricate structures remains challenging.In this study,we developed a novel 3D printing strategy for the precise molding of high-performance PEEK using digital light processing(DLP)to print a photocurable resin,in which ACMO-PEGDA(PACMO)was blended with commercial PEEK powder.In the photocured structure,PEEK powder was confined within the elastic crosslinking network.Each 3D printed PEEK sample underwent individual phase transitions in response to temperature changes.Experimental results confirmed an exceptional shape memory performance,with shape fixation and recovery ratios exceeding 94%.The 4D printed PEEK components exhibited high strength and facilitated the transition from 2D to 3D complex structures.Furthermore,the fabricated components demonstrated an exceptionally low coefficient of friction of below 0.1,offering a groundbreaking solution for customized production of advanced wear-resistant mechanical components.This study represents a significant advancement in PEEK processing technology,establishes new paradigms for high-performance PEEK 3D/4D printing,and opens new avenues for the development of next-generation intelligent devices with enhanced performance. 展开更多
关键词 Shape memory polymers Polymer networks 4D printing Poly(ether-ether-ketone)
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Copper Precipitation Behavior and Mechanical Properties of Cu‑Bearing Ferritic Stainless Steel with Diferent Cr Addition 认领 引用 被引量：1
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作者 Yifan Li Shengyao Ma +4 位作者 Xinrui Zhang Tong Xi Chunguang Yang Hanyu Zhao Ke Yang 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 2025年第3期383-395,共13页
The microstructure evolution and mechanical properties of Cu-bearing ferritic stainless steel with diferent Cr addition(Cr=12,15 and 17 wt%)were investigated.The phase transformation behavior under diferent cooling ra... The microstructure evolution and mechanical properties of Cu-bearing ferritic stainless steel with diferent Cr addition(Cr=12,15 and 17 wt%)were investigated.The phase transformation behavior under diferent cooling rate,Cu-rich precipitation behavior and its infuence on the mechanical properties under diferent aging treatment are systematically characterized using dilatometry,diferential scanning calorimeter(DSC)and transmission electron microscopy(TEM).The results indicated that the increase in Cr content narrowed the austenite phase region at high temperatures,afecting its microstructure under diferent cooling rates.The 12Cr-1.5Cu steel exhibited a fully austenitic phase region at high temperature and occurred apparent martensitic transformation after air cooling.Cooling rate signifcantly infuenced the phase transition of the steels,and subsequently afected its mechanical properties.All three investigated steels showed higher strength and lower plasticity in air cooling condition compared to furnace cooling condition,due to the presence of martensite.After aging treatment,high number densities of Cu-rich precipitates were formed in steel matrix and the size of Cu-rich precipitates increased obviously with increasing aging temperature,while the tendency for number density was opposite.Fine and dispersed Cu-rich precipitates formed during low-temperature aging enhanced strength of the steels,while larger Cu-rich phases developed during high-temperature aging endowed greater ductility to the steels.Notably,the Cr content had no signifcant efect on the precipitation behavior of Cu-rich precipitation.These comprehensive results and analyses could provide a solid foundation for broader applications of Cu-bearing ferritic stainless steels. 展开更多
关键词 Cu-bearing stainless steel Mechanical property Cu-rich precipitate Microstructure
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Ferroptosis-induced anticancer effect of resveratrol with a biomimetic nano-delivery system in colorectal cancer treatment 认领 引用 被引量：33
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作者 Ziting Zhang You Ji +7 位作者 Nan Hu Qinqi Yu Xinrui Zhang Jie Li Fenglei Wu Huae Xu Qiyun Tang Xiaolin Li 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2022年第5期751-766,共16页
Ferroptosis is a novel form of programmed cell death impelled by iron-dependent lipid peroxidation,which may be a potential strategy for cancer therapy.Here we demonstrated for the first time that Resveratrol(RSV),a t... Ferroptosis is a novel form of programmed cell death impelled by iron-dependent lipid peroxidation,which may be a potential strategy for cancer therapy.Here we demonstrated for the first time that Resveratrol(RSV),a traditional Chinese medicine(TCM)chemical monomer,could effectually inhibit the growth of colon cancer cells through the ROS-dependent ferroptosis pathway.Mechanistically,RSV evoked the increase of reactive oxygen species and lipid peroxidation in colorectal cancer cells,and eventually lead to ferroptosis.Furthermore,RSV could promote ferroptosis by downregulating the expression of the channel protein solute carrier family 7 member 11(SLC7A11)and glutathione peroxidase 4(GPX4).To improve the delivery efficiency of RSV,a biomimetic nanocarrier was developed by coating RSV-loaded poly(ε-caprolactone)-poly(ethylene glycol)(PCL-PEG)nanoparticles with erythrocyte membrane(RSV-NPs@RBCm).The RSV-NPs@RBCm provide the possibility to escape macrophage phagocytosis and have a long circulation effect.In addition,when coupled with a tumor-penetrating peptide iRGD,which could trigger enhanced tissue penetration tumor-specifically,the delivery of RSV-NPs@RBCm into tumors would be significantly improved results from the in vivo study demonstrated an excellent treatment efficacy for CRC.Altogether,our study highlighted the therapeutic potential of RSV as a ferroptosis-inducing anticancer agent and when loaded into a biomimetic nanoplatform,it might pave the way for the application of RSV loaded nanosystems for colorectal cancer treatment. 展开更多
关键词 Resveratrol Red-blood-cell membrane Colorectal cancer Ferroptosis IRGD
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Study on enzymatic hydrolysis of soybean β-conglycinin using alkaline protease from Bacillus subtilis ACCC 01746 and antigenicity of its hydrolysates 认领 引用 被引量：14
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作者 Haicheng Yin Xinrui Zhang Jin Huang 《Grain & Oil Science and Technology》 EI CAS 2021年第1期18-25,共8页
Due to its beneficial health effects,the use of soybean protein has shown a continuous increase,but concerns regarding the allergenicity of soybean antigenic protein have also increased.This study aimed to evaluate th... Due to its beneficial health effects,the use of soybean protein has shown a continuous increase,but concerns regarding the allergenicity of soybean antigenic protein have also increased.This study aimed to evaluate the hydrolytic effects of a non-commercial alkaline protease isolated from the Bacillus subtilis ACCC 01746 on soybeanβ-conglycinin and the allergenicity of its hydrolysates.Alkaline protease of the strain was separated by precipitation method of organic solvents,and theβ-conglycinin was separated by alkali-solution and acid-isolation and purified by use of gel column.Using the degree of hydrolysis(DH)and inhibition rate as evaluation indexes,the enzymatic hydrolysis parameters ofβ-conglycinin was optimized by single factor and L9(34)orthogonal tests,so as to explore the effect of the protease on the hydrolysis degree and the antigenicity ofβ-conglycinin hydrolysates.The results showed that the native enzyme existed as an 18.3 kDa monomer with a 430 U/g maximum activity.The purity ofβ-conglycinin was 84.8%.The single-factor test results showed that DH showed the oppostie trendency with the inhibition rate,and the increase of protein concentration causedmonotone increasing and monotone decreasing of the inhibition rate and the DH,and the optimal protein concentration was 30 mg/mL.The optimization results showed that pH had the largest impacts on both DH and the inhibition rate,followed by enzyme dosage,hydrolysis temperature and hydrolysis time.Under the optimum hydrolysis conditions of protein concentration 30mg/mL,enzymedosage0.7%,hydrolysis time40min,temperature 55°C and pH8.5,the DH reached the highest of 76.28%,and the inhibition rate was the lowest of 27.03%,which was reduced greatly compared with that before optimization.These results suggested that alkaline protease appeared to show a relatively high effeciency in lowering soybean allergenicity,making it possible to produce low-allergenicity soybean protein. 展开更多
关键词 Alkaline protease Bacillus subtilis ACCC 01746 β-conglycinin Hydrolysis degree Antigenicity
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Synergistic addition of Cu and Ce enhanced sulfate reducing bacteria-assisted corrosion cracking resistance of 2205 duplex stainless steel 认领 引用 被引量：4
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作者 Hanyu Zhao Yueyang Gu +5 位作者 Xinrui Zhang Boxin Wei Tong Xi Jinlong Zhao Chunguang Yang Ke Yang 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2024年第29期1-11,共11页
The corrosion behaviors of 2205,2205-Cu,and 2205-Cu-Ce duplex stainless steels(DSSs)were studied under static load in the presence of sulfate-reducing bacteria(SRB).The results demonstrated that the addition of Cu and... The corrosion behaviors of 2205,2205-Cu,and 2205-Cu-Ce duplex stainless steels(DSSs)were studied under static load in the presence of sulfate-reducing bacteria(SRB).The results demonstrated that the addition of Cu and Ce effectively enhanced the resistance of 2205 DSS to SRB-assisted cracking,and 2205-Cu-Ce DSS exhibited the best corrosion resistance and mechanical properties.The Synergistic addition of Cu and Ce not only inhibited the formation of SRB biofilm but also enhanced the hydrogen-induced cracking resistance of DSSs due to the hydrogen trapping by Cu-rich precipitates. 展开更多
关键词 Duplex stainless steel Sulfate-reducing bacteria Microbiologically influenced corrosion Stress corrosion Hydrogen trap
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Effect of extrusion on the structure and antigenicity of soybean β-conglycinin 认领 引用 被引量：6
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作者 Haicheng Yin Feng Jia +3 位作者 Jin Huang Yong Zhang Xin Zheng Xinrui Zhang 《Grain & Oil Science and Technology》 CAS 2019年第3期67-72,共6页
β-Conglycinin,the main component of 7S globulin in soybean protein,is also a key soybean antigen protein that causes allergic reactions.Extrusion technologies have received considerable attention as amethod for modif... β-Conglycinin,the main component of 7S globulin in soybean protein,is also a key soybean antigen protein that causes allergic reactions.Extrusion technologies have received considerable attention as amethod for modifying soybean protein allergens.This study investigated the changes inβ-conglycinin structure and antigenicity upon extrusion.Isoelectric precipitation,ammoniumsulfate precipitation,and sepharose CL-6B gel filtration were used to isolate and purifyβ-conglycinin from soybean powder,and single-factor and orthogonal tests were used to study the effects of water content,extrusion temperature,screw rotation speed,and feeding speed on the antigenicity ofβ-conglycinin after extrusion.Fourier transforminfrared spectrometry(FTIR)was then employed to analyze the structure ofβ-conglycinin after extrusion under the optimal conditions determined by the orthogonal test.The results showed that extrusion significantly reduced the antigenicity ofβ-conglycinin(Pfeeding speed>screw rotation speed>water content.The optimal parameters were temperature at 130°C,screwrotation speed at 140 r/min,and feeding speed at 35 g/min.Under these conditions,the contents ofα-helix,β-pleated sheet,andβ-turn structures inβ-conglycinin were significantly reduced(P<0.05),while the contents of random coils were significantly increased(P<0.05).The peak absorption intensity of amides I,II,and III also decreased.Taken together,the findings suggest that extrusion could be an effective method for reducing the antigenicity ofβ-conglycinin. 展开更多
关键词 Soybean Extrusion β-Conglycinin Structure Antigenicity
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Dissolution and repair of passive film on Cu-bearing 304L stainless steels immersed in H_2SO_4 solution 认领 引用 被引量：5
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作者 Xinrui Zhang Jinlong Zhao +3 位作者 Tong Xi M.Babar Shahzad Chunguang Yang Ke Yang 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2018年第11期2149-2159,共11页
The antibacterial Cu-bearing 304 L stainless steel is a new kind of structural and functional integrated metal material. In this work, evolution behavior of passive film of different heat treated Cu-bearing 304 L stai... The antibacterial Cu-bearing 304 L stainless steel is a new kind of structural and functional integrated metal material. In this work, evolution behavior of passive film of different heat treated Cu-bearing 304 L stainless steel immersed in 0.5 M H2SO4 solution was investigated by using electrochemical measurements, atomic force microscopy（AFM） observation and X-ray photoelectron spectroscopy（XPS） analysis.The results show that the solution and aging treated samples have the similar polarization behaviors. The passive film impedance experiences an initial decrease within 7 days followed by a subsequent increase,while the defect density of passive film presents the opposite trend. Meanwhile, the evolution of surface morphology and the estimated thickness of the passive film confirm that it experiences initial dissolution and follow-up repair. Furthermore, the Cr^3＋ content in passive film undergoes sequential reduction to increase, however the variation tendency of Cu^2＋ content is just opposite, indicating that the content variation of Cr and Cu in passive film reflects the competitive process of film dissolution and repair. In addition, compared with solution treated samples, aged samples have a bigger icorrvalue and the rougher passive film. This indicates that the passive film of solution treated steel is more compact and stable. 展开更多
关键词 Cu-bearing stainless steel 304L-Cu Passive film
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New strategy to delay food spoilage:Application of new food contact material with antibacterial function 认领 引用 被引量：3
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作者 Xinrui Zhang Xiaofang Liu +4 位作者 Chunguang Yang Tong Xi Jinlong Zhao Lichu Liu Ke Yang 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2021年第11期59-66,共8页
Frequent food poisoning and food-borne diseases outbreaking in recent years have caused people to attach great attention to food safety,especially the food contact materials that are essential in the food industrial c... Frequent food poisoning and food-borne diseases outbreaking in recent years have caused people to attach great attention to food safety,especially the food contact materials that are essential in the food industrial chains and daily lives,ensuring their clean sanitation are of great importance in blocking microbial contamination and spread of food-borne pathogens.Stainless steel(SS)is one of the most accepted and widely used food contact material,and the Cu-bearing SS possesses excellent antibacterial performance and maintains the original mechanical properties of SS,maybe making it a better substitute for the conventional SS in the food area.Taking advantages of bactericidal and antifouling properties of Cubearing SS,this study simulated a variety of food contact scenarios,explored a new strategy for food preservation and food safety by using Cu-bearing SS as a food contact material.The results showed that the Cu-bearing SS could not only delay the spoilage of different foods by inhibiting the activity of microorganisms in foods,but also reduce the expressions of spoilage traits of bacteria as well as the formation of biofilms by quenching the quorum-sensing signals,and further creating a good bacteriostatic atmosphere for the contacted food and its surrounding environment.In addition,the remarkable antifouling property of Cu-bearing SS would give the material a self-cleaning feature for food applications,which can avoid secondary contamination of food as a source of contamination.This study well demonstrates that the Cu-bearing SS has broad application potentials and prospects in the food area. 展开更多
关键词 Cu-bearing stainless steel Antibacterial Food contact material Microbial contamination Food spoilage
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Enzymatic kinetics ofβ-conglycinin using alkaline protease from Bacillus subtilis ACCC 01746 and analysis of antigenicity of hydrolyzed peptide 认领 引用 被引量：3
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作者 Haicheng Yin Xinrui Zhang +1 位作者 Zhixiang Yang Jin Huang 《Grain & Oil Science and Technology》 EI CAS 2021年第3期141-148,共8页
β-Conglycinin,the main protein of soybean,is a key allergen that causes soybean allergies,and hydrolysis is usually applied to lower its antigenicity.We evaluated the enzymolysis characters ofβ-conglycinin from the ... β-Conglycinin,the main protein of soybean,is a key allergen that causes soybean allergies,and hydrolysis is usually applied to lower its antigenicity.We evaluated the enzymolysis characters ofβ-conglycinin from the perspective of enzymolysis kinetics using alkaline protease from B.subtilis ACCC 01746.A dynamic model describing the hydrolysis ofβ-conglycinin was proposed using the initial substrate concentration,enzyme dosage(enzyme to substrate ratio)and hydrolysis time as variables to illustrate the kinetic behavior of enzymatic hydrolysis.The hydrolysis of soybeanβ-conglycinin was carried out at 60 g/L protein concentration,0.6%enzyme dosage,55℃ and pH 8.5 to observe the peptides with anti-enzymatic activities.The hydrolysates were gradually fractionated by ultrafiltration through cut-off membranes with molecular weights of 40,30,20,and 10 kDa,and their antigenicities were evaluated using indirect competitive enzyme-linked immunosorbent assay.The results showed that the degree of hydrolysis(DH)ofβ-conglycinin decreased as theβ-conglycinin concentration(S0)increased,but increased with enzyme dosage(E0)increasing.Thus,the enzymatic hydrolysis ofβ-conglycinin followed the first-order kinetics model.The hydrolysis rate(V)was(527.89CE0-2.5533CS0)exp(-0.022DH),the DH-hydrolysis time was 45.454ln[1+(11.614CE0/CS0-0.0562)t],and the correlated kinetic constants k2 and kd were 527.89 min−1and 8.6126 min−1,respectively.The hydrolysis behavior ofβ-conglycinin varied considerably among theα',α,andβsubunits.Faster hydrolysis rates were observed for theα'andαsubunits compared to theβsubunit.The relative molecular weights of the intercepted peptides from the hydrolysates were 14.8-40.1 kDa,and the antigenicity of the peptides with smaller molecular weight was reduced,but not removed completely.However,the alkaline protease from the strain appeared to effectively reduce the allergenicity ofβ-conglycinin.Therefore,it is possible to produce less allergenic soybean proteins using enzymatic hydrolysis.Additionally,the microbial alkaline protease may serve as a potential novel food enzyme and should be evaluated for the development of hypoallergenic foods. 展开更多
关键词 B.subtilis ACCC 01746 Alkaline protease β-Conglycinin Enzymatic kinetics Antigenicity
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Pore Formation Mechanism in W-C Hard Coatings Using Directed Energy Deposition on Tungsten Alloy 认领 引用 被引量：1
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作者 Xinrui Zhang Weijie Fu +3 位作者 Chen Wang Zhenglong Lei Haoran Sun Xudong Li 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 2024年第1期89-101,共13页
Porosity is a common phenomenon and can significantly hinder the quality of the coating.Here,the pore formation mechanism and the characteristics of the single tracks of the W-C coating using directed energy depositio... Porosity is a common phenomenon and can significantly hinder the quality of the coating.Here,the pore formation mechanism and the characteristics of the single tracks of the W-C coating using directed energy deposition(DED)are systematically investigated.The forming quality of the tracks,the distribution of the pores,and the elemental distribution near the pores are analyzed by the observations of the cross-sections of the tracks.The temperature field of the melt pool is discussed comprehensively to reveal the pore formation mechanism.The results confirm that Ni and Co evaporated during the DED process due to the high temperature of the melt pool.Pores were continuously produced adjacent to the fusion line when the melt pool was about to solidify since the temperature at the solidification front was higher than the boiling point of Ni.The vaporization area at the fusion line was proposed,where Ni could also evaporate at the time the melt pool started to solidify.The relationship between the solidification rate,the size of the vaporization area and the DED parameters(laser power and scanning speed)was established to discuss the causes of severe pores above the fusion line.This work contains a practical guide to reduce or eliminate the porosity in the coating preparation process on the surface of the tungsten alloy. 展开更多
关键词 Directed energy deposition(DED)process Tungsten alloy W-C coating Pores Binder phase
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Hypoxia-mediated programmed cell death is involved in the formation of wooden breast in broilers 认领 引用
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作者 Xinrui Zhang Tong Xing +2 位作者 Lin Zhang Liang Zhao Feng Gao 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2024年第5期1918-1931,共14页
Background Wooden breast(WB)myopathy is a common myopathy found in commercial broiler chickens worldwide.Histological examination has revealed that WB myopathy is accompanied by damage to the pectoralis major(PM)muscl... Background Wooden breast(WB)myopathy is a common myopathy found in commercial broiler chickens worldwide.Histological examination has revealed that WB myopathy is accompanied by damage to the pectoralis major(PM)muscle.However,the underlying mechanisms responsible for the formation of WB in broilers have not been fully elucidated.This study aimed to investigate the potential role of hypoxia-mediated programmed cell death(PCD)in the formation of WB myopathy.Results Histological examination and biochemical analysis were performed on the PM muscle of the control(CON)and WB groups.A significantly increased thickness of the breast muscle in the top,middle,and bottom portions(P<0.01)was found along with pathological structure damage of myofibers in the WB group.The number of capillaries per fiber in PM muscle,and the levels of p O2 and s O2 in the blood,were significantly decreased(P<0.01),while the levels of p CO2 and TCO2 in the blood were significantly increased(P<0.05),suggesting hypoxic conditions in the PM muscle of the WB group.We further evaluated the PCD-related pathways including autophagy,apoptosis,and necroptosis to understand the consequence response to enhanced hypoxic conditions in the PM muscle of birds with WB.The ratio of LC3 II to LC3 I,and the autophagy-related factors HIF-1α,BNIP3,Beclin1,AMPKα,and ULK1 at the m RNA and protein levels,were all significantly upregulated(P<0.05),showing that autophagy occurred in the PM muscle of the WB group.The apoptotic index,as well as the expressions of Bax,Cytc,caspase 9,and caspase 3,were significantly increased(P<0.05),whereas Bcl-2 was significantly decreased(P<0.05)in the WB-affected PM muscle,indicating the occurrence of apoptosis mediated by the mitochondrial pathway.Additionally,the expressions of necroptosis-related factors RIP1,RIP3,and MLKL,as well as NF-κB and the pro-inflammatory cytokines TNF-α,IL-1β,and IL-6,were all significantly enhanced(P<0.05)in the WB-affected PM muscle.Conclusions The WB myopathy reduces blood supply and induces hypoxia in the PM muscle,which is closely related to the occurrence of PCD including apoptosis,autophagy,and necroptosis within myofibers,and finally leads to abnormal muscle damage and the development of WB in broilers. 展开更多
关键词 Apoptosis Autophagy Broiler chicken Hypoxia Necroptosis Wooden breast
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Zein as a structural protein in gluten-free systems:an overview 认领 引用 被引量：8
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作者 Xinrui Zhang Chunxia Dong +2 位作者 Yayun Hu Mengnan Gao Guangzhong Luan 《Food Science and Human Wellness》 SCIE CAS CSCD 2021年第3期270-277,共8页
Zein,a class of alcohol-soluble prolamines in maize endosperm,is mainly composed of α-zein,β-zein,andγ-zein.It has been recognized as a structural protein for various gluten-free systems since it can form glutenlik... Zein,a class of alcohol-soluble prolamines in maize endosperm,is mainly composed of α-zein,β-zein,andγ-zein.It has been recognized as a structural protein for various gluten-free systems since it can form glutenlike viscoelastic network.The formation of viscoelastic zein network can make up for the structural defect of gluten-free doughs caused by the lack of gluten.To make the most of structural functionality of zein in glutenfree foods,it is important to clearly elucidate the fundamental properties of zein network.In this article,these properties have been discussed,analyzed and summarized from the relationship between protein network and structural functionality of zein,the feature and formation mechanism of zein network,factors affecting zein network and the applications of zein network in improving the quality of gluten-free food.In addition,this article also looks forward to potential research areas on zein network. 展开更多
关键词 Zein Gluten-free Network Glass transition
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Bifunctional Two-Dimensional Nanocomposite with Electromagnetic Wave Absorption and Anti-bacterial Performance 认领 引用 被引量：1
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作者 Jiacheng Shen Xinrui Zhang +7 位作者 Chunguang Yang Zixuan Lei Shuaizhen Li Lin Ma Dianyu Geng Song Ma Wei Liu Zhidong Zhang 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 2023年第9期1559-1571,共13页
In current electronic information era,the complex application circumstance of 5G devices pursues the exploration of multi-functional electromagnetic wave(EMW)absorbent materials and it has become the crucial focus in ... In current electronic information era,the complex application circumstance of 5G devices pursues the exploration of multi-functional electromagnetic wave(EMW)absorbent materials and it has become the crucial focus in industrial development.A two-dimensional(2D)graphite nanosheet decorated by nickel nanocapsules(2D graphite/Ni@C nanocomposite)was fabricated to possess the EMW absorption and the Escherichia coli(E.coli)anti-bacterial performance simultaneously.By adjusting the filling ratio and injecting nitrogen doping,the value of minimum reflection loss is−36.08 dB and the effective absorption bandwidth reaches to 5.12 GHz(from 11.4 to 16.52 GHz)with the mass ratio of 30 wt%and the absorber thickness of 2 mm.This 2D nanocomposite simultaneously gets an excellent anti-bacterial function expressing an E.coli anti-bacterial rate of 92%during 24 h which is significantly correlated to the interaction between the nanostructure of the 2D nanographite and the nickel ion released from Ni@C nanocapsules.This work provides a new approach to develop a promising 2D anti-bacterial EMW absorber. 展开更多
关键词 Bifunctional electromagnetic wave absorbent material Nickel-based two-dimensional nanocomposite E.coli anti-bacterial performance
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An Impact of Different Silicone Breast Implants on the Bacterial Attachment and Growth 认领 引用
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作者 Sun Young Nam Xinrui Zhang +3 位作者 Omar Faruq Pham Ngoc Chien Nilsu Dönmez Chan Yeong Heo 《Journal of Biomaterials and Nanobiotechnology》 2021年第3期21-33,共13页
Bacterial biofilms have been implicated with breast implant complications including capsular contracture, double-capsule formation, and breast implant-associated anaplastic large cell lymphoma. However, the relationsh... Bacterial biofilms have been implicated with breast implant complications including capsular contracture, double-capsule formation, and breast implant-associated anaplastic large cell lymphoma. However, the relationship between implant surface texture and microbial biofilm formation is insufficiently evaluated. In the present study, we examined the antimicrobial activities of different types of silicone breast implant. The growth of bacterial including Staphylococcus aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa was compared using implants with various surface textures, including Hans Smooth, Hans SmoothFine, Allergan Smooth, Eurosilicone Smooth, Eurosilicone Texture, Sebbin Smooth, Sebbin Micro, Sebbin Texture, and Motiva Smooth. Microbial investigation revealed the increased growth of S. aureus on breast implants after 48 h, except Eurosilicone Smooth, Eurosilicone Texture, Hans SmoothFine and Sebbin Smooth material. At 48 hours, there was no major difference between the S. aureus attachment on smooth and textured implants. The results of S. epidermis attachment on the implant after 48 h showed that their growth decreased on surfaces of Motiva Smooth, Sebbin Smooth, and Eurosilicone Smooth. These results indicated that S. epidermis was unable to survive on these breast implants. Eventually, P. aeruginosa count had showed decrease of bacterial count after 48 hours compared to 24 hours in most of the implants except for Eurosilicone Texture, Sebbin Smooth and Sebbin Micro, where the count of P. aeruginosa slightly increased. This indicated that P. aeruginosa was unable to exist on the smooth surfaces. Our results show that the in vitro assay revealed no significant difference between smooth and textured surfaces and showed variable interactions and needed further molecular analysis to assess their adherence nature. 展开更多
关键词 Silicone Implants Surface Texture Biofilm Staphylococcus epidermidis Staphylococcus aureus Pseudomonas aeruginosa Bacterial Attachment
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Liposoluble Constituents from the Flowers of Calotropis Gigantea and Their Antimicrobial Activity 认领 引用
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作者 Maoyuan WANG Jianrong WANG +2 位作者 Xinrui ZHANG Xiaoxia YAN Zhunian WANG 《Medicinal Plant》 2017年第5期1-3,共3页
[Objectives] To study the liposoluble constituents and their antimicrobial activity from the flowers of Calotropis gigantea.[Methods]The liposoluble constituents from the flowers of Calotropis gigantea were analyzed b... [Objectives] To study the liposoluble constituents and their antimicrobial activity from the flowers of Calotropis gigantea.[Methods]The liposoluble constituents from the flowers of Calotropis gigantea were analyzed by gas chromatography-mass spectrometry(GCMS) method and their relative content was determined by area normalization method; and their antimicrobial activity against 2 pathogens was tested by agar disc diffusion method. [Results]31 compounds were separated and identified,amounting to 85. 14% of the total constituents,27 compounds were reported for the first time in the study of the liposoluble constituents from Calotropis gigantea. The results indicated that the liposoluble constituents from the flowers of Calotropis gigantea exhibited weak antimicrobial activity against Staphylococcus aureus and Canidia albicans. [Conclusions] The research results provided scientific foundation for exploitation and utilization of Calotropis gigantea. 展开更多
关键词 Calotropis gigantea Flowers Liposoluble constituents Antimicrobial activity GC-MS
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Visinin-like protein 1 disrupts calcium homeostasis and promotes atrial fibrillation in human and rodent models 认领 引用
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作者 Ke Xiong Guanghua Wang +15 位作者 Desheng Li Beihua Shao Zhiwen Chen Qicheng Zou Xinrui Zhang Yanru Dong Xuxia Zhao Yixin Yuan Hongtao Xu Yi Liu Dandan Liang Li Wang Bin Zhou Nianguo Dong Duanyang Xie Yi-Han Chen 《Signal Transduction and Targeted Therapy》 SCIE CSCD 2026年第4期2464-2480,共17页
Atrial fibrillation(AF),the most prevalent sustained cardiac arrhythmia,is closely linked to disturbed intracellular Ca2+homeostasis.Visinin-like protein 1(VILIP-1),newly identified in cardiomyocytes,has been impli... Atrial fibrillation(AF),the most prevalent sustained cardiac arrhythmia,is closely linked to disturbed intracellular Ca2+homeostasis.Visinin-like protein 1(VILIP-1),newly identified in cardiomyocytes,has been implicated in modulating Ca2+signaling,yet its role in AF remains undefined.In this study,we integrated bulk RNA sequencing,single-cell transcriptomics,and electrophysiological profiling from human AF patients and rodent AF models to identify VILIP-1 as a key mediator of Ca2+dysregulation in AF.VILIP-1 was significantly upregulated in atrial tissues from AF patients and in pacing-induced rat AF models,with enhanced membrane localization in cardiomyocytes.Atrial cardiomyocyte-specific overexpression of VILIP-1 led to pathological Ca2+leakage,promoting delayed afterdepolarizations(DADs)and action potential duration(APD)alternans,which fostered AF substrate formation and increased arrhythmia susceptibility.Mechanistically,VILIP-1 augmented the surface abundance of sodium-calcium exchanger 1(NCX-1)via a myristoylation-dependent trafficking mechanism,thereby disrupting Ca2+handling and initiating AF.Pharmacologically,repaglinide and desloratadine,two FDA-approved drugs that identified to target VILIP-1 or its myristoylation,attenuated AF susceptibility by reducing NCX-1 surface expression and restoring intracellular Ca2+homeostasis.Collectively,our findings define VILIP-1 as a critical upstream modulator of atrial Ca2+homeostasis and establish it as a promising therapeutic target for AF,with efficacy validated in human and rodent models. 展开更多
关键词 rodent af models bulk rna sequencingsingle cell atrial fibrillation af calcium homeostasis cardiac arrhythmiais atrial fibrillation cardiac arrhythmia visinin protein
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JS-K induces autophagy-dependent ferroptosis in bladder cancer:a multimodal mechanistic and translational study 认领 引用
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作者 Zhuo Li Haitao Zhong +10 位作者 Daniel Baptista-Hon Jingping Qiu Zhongwei Zhang Xinrui Zhang Yuwan Zhao Lugang Zhu Sheng Gao Bin Li Olivia Monteiro Jianjun Liu Yumin Zhuo 《Precision Clinical Medicine》 2026年第2期277-291,共15页
Background:Bladder cancer is the most common urological malignancy.Bladder cancer has limited therapeutic options,especially in advanced stages.Ferroptosis,an iron-dependent form of regulated cell death,has emerged as... Background:Bladder cancer is the most common urological malignancy.Bladder cancer has limited therapeutic options,especially in advanced stages.Ferroptosis,an iron-dependent form of regulated cell death,has emerged as a promising target for cancer therapy.However,the role of autophagy in modulating ferroptosis remains incompletely understood.Methods:We investigated the anti-tumor effects of JS-K,a nitric oxide-releasing prodrug,in bladder cancer through integrated cell,animal,and patient data studies.In vitro experiments with T24 and UM-UC-3 cells were used to explore how JS-K influences cancer cell survival and the interplay between autophagy and ferroptosis.In vivo,a BALB/c nude mouse tumor model provided a system to examine tumor response and tissue-level changes.To extend these findings to the clinical setting,we analyzed LC3B expression and its associations with ferroptosis-related genes,patient prognosis,and the tumor immune microenvironment.Results:JS-K induced mitochondrial damage,lipid peroxidation,reactive oxygen species accumulation,and intracellular iron overload in bladder cancer cells in a concentration-dependent manner.These changes were accompanied by downregulation of GPX4 and SLC7A11 and upregulation of FTH1 and TFR1,indicative of ferroptosis.Inhibition or knockdown of the autophagy marker LC3B reversed these effects,establishing the role of autophagy in mediating ferroptosis.In xenograftmodels,JS-K suppressed tumor growth,an effect abrogated by LC3B silencing.Integrated transcriptomic and single-cell analyses revealed a strong correlation between LC3B and ferroptosis-related genes,with CISD1 identified as a key prognostic marker.Conclusions:JS-K induces autophagy-dependent ferroptosis in bladder cancer cells and significantly suppresses tumor progression.Targeting the autophagy-ferroptosis axis offers a novel therapeutic strategy for bladder cancer treatment. 展开更多
关键词 bladder cancer ferroptosis autophagy JS-K GPX4 CISD1
Exploring the Influences of Continuous Self-Management Education on the Self-Care Skills and Health Behavior of Patients with PICC Intubation 认领 引用
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作者 Xinrui Zhang Huiying Huang +3 位作者 Chunyan Yang Yanfang Du Xinying Wang Juan Zhang 《Journal of Clinical and Nursing Research》 2021年第1期16-19,共4页
Objective:To analyze the effects of continuous self-management education on the selfcare ability and health behavior of patients with tumor through peripherally inserted central venous catheters(PICC).Methods:The peri... Objective:To analyze the effects of continuous self-management education on the selfcare ability and health behavior of patients with tumor through peripherally inserted central venous catheters(PICC).Methods:The period from August 2018 to August 2020 was used as the research time range,and the random number table method was used as the basis for grouping.80 patients with malignant tumors who regularly performed fixed catheter maintenance care in the PICC clinic of our hospital were admitted in the experimental group(given PICC specialist nursing,and implemented continuous self-management education),and 80 patients with PICC tube malignant tumors discharged from the superior hospital during this time range served as the control group(return to the original catheterization hospital from time to time or perform catheter maintenance care in the nursing clinic of our hospital).The self-care ability scores,health behavior scores,and complications during intubation between both groups were analyzed.Results:(1)There was no significant difference in self-care ability score and healthy behavior score between groups before the intervention,P>0.05;the self-care ability score and health behavior score of the research group were better than the control group after intervention,P0.05.Conclusion:Continuous self-management education has good effects on improving the self-care ability of tumor patients with PICC intubation.It can urge patients to maintain good health behaviors and reduce complications.It is worthy of promotion. 展开更多
关键词 Continuous self-management education PICC catheterization Tumor Self-care ability Health behavior
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