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Esterified resistant dextrin for delivery of short-chain fatty acids:Characterization,release,and microbiota impact 认领 引用
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作者 Yahui Xie Xinzhu Zhao +5 位作者 Guimei Liu Haiteng Tao Haibo Zhao Xuemin Kang Bin Yu Bo Cui 《Food Bioscience》 SCIE 2026年第5期1134-1144,共11页
Short-chain fatty acids(SCFAs)are key colonic metabolic regulators,yet microbiota endogenous biosynthesis often falls short of therapeutic requirements.To address this limitation,a colon-targeting delivery system was ... Short-chain fatty acids(SCFAs)are key colonic metabolic regulators,yet microbiota endogenous biosynthesis often falls short of therapeutic requirements.To address this limitation,a colon-targeting delivery system was developed by covalently coupling SCFAs with resistant dextrin(RD).FTIR and moderate molecular-weight distribution confirmed the esterification success and homogeneity.1H NMR verified preservation of the indi-gestible glycosidic bond,a structural prerequisite for resistance to upper gastrointestinal digestion.The esterified RD(ERD)demonstrated remarkable stability under simulated digestion.In vitro fermentation assays revealed high-substitution ERD induced approximately three-fold increase in total SCFAs production compared to RD.In vivo microbiome analysis showed ERD increased beneficial bacteria like Bacteroidota,Firmicutes,and Verruco-microbiota.Non-targeted metabolomics further demonstrated that distinct ERDs modulate host metabolism by regulating specific metabolic pathways.This study introduces ERD as a novel SCFA-delivery material to the colon,providing a novel strategy for the development of precision functional foods aimed at intestinal health. 展开更多
关键词 Resistant dextrin Esterification Short-chain fatty acids Intestinal microbiota Colon-targeted delivery
Transcriptomic analysis reveals the landscape of the shared gene network between ectopic pregnancy and early pregnancy loss 认领 引用
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作者 Mengyu Jing Ying Zhou +3 位作者 Shuyue Zheng Yahui Xie Xi Chen Aixia Liu 《Genes & Diseases》 SCIE CSCD 2025年第6期47-50,共4页
The loss of a pregnancy,including ectopic pregnancy(EP)and early pregnancy loss(EPL),significantly impacts women’s quality of life.Unfortunately,definitive causes can be identified in less than half of EP and EPL cas... The loss of a pregnancy,including ectopic pregnancy(EP)and early pregnancy loss(EPL),significantly impacts women’s quality of life.Unfortunately,definitive causes can be identified in less than half of EP and EPL cases,presenting a substantial challenge for clinical treatment.Previous studies have revealed a significant relationship between the history of EPL and the increased risk of EP.1 Nevertheless,the interplay between EPL and EP remains unclear,highlighting the need to discover novel biomarkers to guide personalized treatment and clinical management. 展开更多
关键词 early pregnancy loss epl significantly ectopic pregnancy discover novel biomarkers guide transcriptomic analysis gene network early pregnancy loss biomarkers ectopic pregnancy ep
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