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Advanced multifunctional nano-delivery platform focusing on treating diseases related to lipid metabolism via targeted intervention in various lipid metabolic processes 认领 引用
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作者 Ying Sun Kai Yan +8 位作者 Yi Zhang Yan-Qi Han Long-Hui Hao Yue Gao Hong-Liang Wang Hong-Qian Chu Jun Ye Yu-Ling Liu Yan-Fang Yang 《Military Medical Research》 SCIE CAS CSCD 2026年第7期1123-1170,共48页
Disruptions in lipid metabolism cause numerous metabolic diseases,including obesity,diabetes,cardiovascular diseases,and liver disorders.Consequently,lipid metabolism serves as a potential therapeutic target,influenci... Disruptions in lipid metabolism cause numerous metabolic diseases,including obesity,diabetes,cardiovascular diseases,and liver disorders.Consequently,lipid metabolism serves as a potential therapeutic target,influencing the progression of various non-metabolic diseases such as kidney diseases,cancer,neurodegenerative disorders,aging,and bone-related diseases.The metabolic pathways involved in lipid metabolism are complex and highly interconnected.Although the abundance of metabolic targets presents opportunities for lipid metabolism regulation,the limited precision and safety of traditional therapeutic approaches remain significant challenges.These limitations have catalyzed the development of multifunctional nano-delivery platforms aimed at targeted intervention in lipid metabolic processes,further enhancing the flexibility of lipid metabolism regulation.This review outlines the latest advancements and representative applications of these multifunctional nano-delivery platforms.Notably,extensive research has been conducted on nanoparticles and liposomes,with these technologies being relatively mature.Furthermore,numerous novel biomaterials,including engineered adipocytes,exosome vesicles secreted by natural cells,smart-responsive nanomicelles,composite hydrogels,and engineered lipid droplets,are being increasingly explored.Finally,the review discusses the advantages of drug delivery strategies based on the targeted intervention of lipid metabolic processes,the limitations of current technologies,promising future research directions,and treatment challenges. 展开更多
关键词 Multifunctional nano-delivery system Lipid metabolism Lipid metabolism reprogramming Lipid metabolism-related diseases
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Bioactivity-based UPLC/Q-TOF/MS strategy for screening of anti-inflammatory components from Cimicifugae Rhizoma 认领 引用 被引量：2
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作者 Zeng-Yong Wang Qian Wang +4 位作者 Yan-Qi Han Min Jiang Jie Gao Yan Miao Gang Bai 《Chinese Chemical Letters》 SCIE CAS CSCD 2017年第2期476-481,共6页
In this study,the protective effects of Cimicifugae Rhizoma（CR） was demonstrated in Pseudomonas aeruginosa-induced pneumonia mouse model.To identify the anti-inflammatory ingredients,an ultraperformance liquid chrom... In this study,the protective effects of Cimicifugae Rhizoma（CR） was demonstrated in Pseudomonas aeruginosa-induced pneumonia mouse model.To identify the anti-inflammatory ingredients,an ultraperformance liquid chromatography quadrupole time-of-flight mass spectrometry（UPLC/Q-TOF-MS）integrated nuclear factor κB（NF-κB） luciferase reporter assay screening system was carried out.As a result,some caffeic acid derivatives,including caffeic acid,ferulic acid/isoferulic acid,fukinolic acid,and cimicifugic acid ingredients were identified as the potential effective compounds from CR.For testing the anti-inflammatory capacity,caffeic acid was demonstrated to inhibit NF-kB and reduce the levels of IL-6 and IL-8 in TNF-α-treated BEAS-2B cells in a dose-dependent manner.Hence,CR preparations and its cinnamic acid derivatives have the possibility to be developed as a complementary therapy in the treatment of respiratory system infection in clinics. 展开更多
关键词 Cimicifugae Rhizoma Pseudomonas aeruginosa Pneumonia NF-κB Caffeic acid derivatives
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丝素蛋白水凝胶在骨关节炎中的应用研究 认领 引用 被引量：1
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作者 陈微 孙倩雯 +4 位作者 韩艳琪 叶军 王洪亮 刘玉玲 杨艳芳 《药物流行病学杂志》 CAS 2023年第5期582-589,共8页
随着人口老龄化程度的加剧,骨关节炎患者逐年增多,对人类健康形成了严重威胁。然而,到目前为止,对骨关节炎还缺乏令人满意的临床治疗方法。丝素蛋白是一种天然高分子材料,具有良好的生物相容性、生物可降解性和优良的机械性能等特点,被... 随着人口老龄化程度的加剧,骨关节炎患者逐年增多,对人类健康形成了严重威胁。然而,到目前为止,对骨关节炎还缺乏令人满意的临床治疗方法。丝素蛋白是一种天然高分子材料,具有良好的生物相容性、生物可降解性和优良的机械性能等特点,被广泛应用于骨组织工程领域。近年来,随着对丝素蛋白研究的不断深入,越来越多的学者开始尝试以丝素蛋白水凝胶为载体治疗骨关节炎,结果表明,其在骨关节炎的治疗中具有巨大的应用潜能。本文总结了迄今为止关于骨关节炎发病机制、常用药物以及丝素蛋白水凝胶治疗骨关节炎的研究进展,为进一步探索应用丝素蛋白水凝胶治疗骨关节炎奠定了基础。 展开更多
关键词 骨关节炎 丝素蛋白 水凝胶 天然药用材料
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