Near-infrared second window(NIR-Ⅱ;1000-1700 nm)phosphor-converted light-emitting diodes(pc-LEDs)have received substantial attention owing to their widespread applications in night vision,bioimaging,and nondestructive...Near-infrared second window(NIR-Ⅱ;1000-1700 nm)phosphor-converted light-emitting diodes(pc-LEDs)have received substantial attention owing to their widespread applications in night vision,bioimaging,and nondestructive testing.However,efficient NIR-Ⅱbroadband phosphors that can be excited by commercially available blue-LED chips are lacking.Ni2+-activated phosphors typically emit in the NIR-Ⅱregion;however,because of their poor absorption in the blue-light region,their quantum efficiency is low.Herein,Cr3+,Ni2+-coactivated NIR Mg2YVO6(MYVO)double-perovskite phosphors were synthesized via the high-temperature solid-state reaction,realizing double emission in the NIR-ⅠandⅡregions ranging from 700 to 1700 nm.Under 473 nm excitation,owing to the efficient energy transfer(ET)from Cr3+to Ni2+,the MYVO:Cr3+,Ni2+phosphor exhibits an improved NIR-Ⅱemission peak at 1334 nm,demonstrating a full-width at half maximum of 240 nm.Compared with that of MYVO:0.015Ni2+,the internal quantum efficiency of MYVO:0.015Cr3+,0.015Ni2+increases from 15.4%to 42.4%while maintaining excellent overall thermal stability(89.34%at 423 K).Finally,the MYVO:Cr3+,Ni2+phosphor is combined with a 475 nm blue chip to fabricate an NIR pc-LED,demonstrating the potential applications of NIR-Ⅱlight sources in night vision,biological imaging,and spectral analysis.The codoping of Cr3+and Ni2+addresses the issue of the ineffective excitation of Ni2+luminescence by blue light,providing a design approach to the development of numerous ultra-broadband NIR-Ⅱpc-LEDs based on blue-LED chips.展开更多
Hymoins A–C(1–3),three unusual polycyclic polyprenylated acylphloroglucinols(PPAPs)were isolated from the flowers of Hypericum monogynum.Hymoin A features the first intriguing 6/5/5/5/7 pentacyclic caged PPAP.Hymoin...Hymoins A–C(1–3),three unusual polycyclic polyprenylated acylphloroglucinols(PPAPs)were isolated from the flowers of Hypericum monogynum.Hymoin A features the first intriguing 6/5/5/5/7 pentacyclic caged PPAP.Hymoin B is characterized by an unprecedented rearranged 5/6/8 tricyclic ring system,while hymoin C represents the first rearranged PPAP with a fantastic spirocyclic 5/6/7 ring system.Their structures were established by extensive spectroscopic analysis,X-ray crystallography,and computational methods.The plausible biosynthetic routes for the compounds were also proposed.In oleic acid(OA)-induced HepG2 cells,all compounds exhibited significant lipid-lowering activity at the concentrations of 2–8μmol/L.Further mechanistic study implied that compound 1 exhibited excellent lipid-lowering activity in OA-induced HepG2 cells through inhibiting the proteins of free fatty acids synthesis and improving lipidolysis.展开更多
Drought stress negatively affects grapevine growth and development.Grafting with rootstock is widely used to improve the quality of grape fruits and confer drought stress tolerance,but the underlying genetics and regu...Drought stress negatively affects grapevine growth and development.Grafting with rootstock is widely used to improve the quality of grape fruits and confer drought stress tolerance,but the underlying genetics and regulatory mechanisms are unclear.Hence,we investigated the physiologic and transcriptomic profiles in the leaves of grafted SM/1103P(SM shoot/1103P root)and self-rooted SM(‘Shine Muscat')as well as roots of grafted SM/1103P and self-rooted 1103P under drought stress conditions.The results indicated that grafted grapevine effectively attenuated drought damage in grape leaves by increasing phytohormone levels and antioxidant enzyme activities,reducing H2O2 and MDA contents.Transcriptomic profiling revealed a total of 11,855 and 11,197 differentially expressed genes(DEGs)were identified in grape leaves and roots respectively.Weighted correlation network analysis(WGCNA)was performed based on the RNAseq data,and five modules(greenyellow,black,turquoise,salmon and blue)were significantly correlated to drought stress.Pathway analysis showed that DEGs were enriched in the plant hormone signal transduction and MAPK signaling pathway.916 transcription factor genes(TFs)belonging to different gene families were detected that may participate in regulating the drought stress.Quantitative real-time PCR(q RT-PCR)expression analysis of twelve drought stress responsive DEGs was used to verify the transcriptome data.Furthermore,overexpression of Vv MYBPA1 in Arabidopsis thaliana and grape callus tissues improved drought tolerance.Our findings provided new insights into to the regulatory mechanism for improving grapevine adaptation to drought.展开更多
Biomass structural materials can effectively address the issues of high energy consumption and environmental degradation brought by traditional engineering structural materials.However,natural structural materials oft...Biomass structural materials can effectively address the issues of high energy consumption and environmental degradation brought by traditional engineering structural materials.However,natural structural materials often suffer from drawbacks such as low mechanical performance and flammability.Therefore,this study has developed an ultra-strong fire-resistant bamboo composite(UFBC).Natural bamboo(NB)was used as the raw material.After delignification treatment,bamboo fibers are grafted with epoxy groups through in-situ chemical bonding.Subsequently,polymer chains underwent in-situ chemical cross-linking within the bamboo fiber framework,combined with reinforcement from nano silica,resulting in strengthened cell walls.In addition,the softened and expanded cell walls can facilitate the deposition of phosphate and borate salt on the cell walls,forming an N-P-B flame-retardant system within the system.The tensile strength(463 MPa vs NB 112 MPa)and flexural strength(655 MPa vs NB 157 MPa)of UFBC increased fourfold,with a Limiting Oxygen Index(LOI)of 54.4%.Compared to similar bamboo-based composite materials,UFBC exhibits superior environmental friendliness and sustainability throughout its lifecycle,with all 18 environmental factors being optimized(up to a 92%reduction).This study provides an important reference for the application of high-performance biomass structural materials in construction and industry.展开更多
Alzheimer’s disease(AD)is a complex,progressive neurodegenerative disorder.The subtle and insidious onset of its pathogenesis makes early detection of a formidable challenge in both contemporary neuroscience and clin...Alzheimer’s disease(AD)is a complex,progressive neurodegenerative disorder.The subtle and insidious onset of its pathogenesis makes early detection of a formidable challenge in both contemporary neuroscience and clinical practice.In this study,we introduce an advanced diagnostic methodology rooted in theMed-3D transfermodel and enhanced with an attention mechanism.We aim to improve the precision of AD diagnosis and facilitate its early identification.Initially,we employ a spatial normalization technique to address challenges like clarity degradation and unsaturation,which are commonly observed in imaging datasets.Subsequently,an attention mechanism is incorporated to selectively focus on the salient features within the imaging data.Building upon this foundation,we present the novelMed-3D transfermodel,designed to further elucidate and amplify the intricate features associated withADpathogenesis.Our proposedmodel has demonstrated promising results,achieving a classification accuracy of 92%.To emphasize the robustness and practicality of our approach,we introduce an adaptive‘hot-updating’auxiliary diagnostic system.This system not only enables continuous model training and optimization but also provides a dynamic platform to meet the real-time diagnostic and therapeutic demands of AD.展开更多
Approximately 30% of human cancers are associated with RAS mutation. Ras proteins on the plasma membrane regulate a plenty of important cellular processes. The post-translational modifications(PTMs)of Ras proteins lik...Approximately 30% of human cancers are associated with RAS mutation. Ras proteins on the plasma membrane regulate a plenty of important cellular processes. The post-translational modifications(PTMs)of Ras proteins like lipidation and methylation are crucial for their correct cellular localization and biological function. Hence, obtaining Ras proteins with different kinds of modifications is the necessary prerequisite to investigate their biological properties at molecular level. In this review, we mainly summarize the developed strategies including chemical total synthesis, biosynthesis and semi-synthesis for producing Ras proteins with modifications and their application in biological studies.展开更多
This paper is concerned with the networked predictive control of discrete-time bilinear systems.To deal with the network-induced communication delay that exists in both forward channel(controller to actuator)and fee...This paper is concerned with the networked predictive control of discrete-time bilinear systems.To deal with the network-induced communication delay that exists in both forward channel(controller to actuator)and feedback channel(sensor to controller),a bilinear networked predictive control scheme is proposed.Then a non-convex optimization problem of solving the predictive control sequence is presented,for which two gradually-optimized algorithms are proposed based on the special structure of bilinear system dynamics model.The numerical simulation indicates that the resulting predictive control sequence can compensate for the network-induced issues actively,which proves the effectiveness of the proposed predictive control strategy.展开更多
Oxidative therapies receive a limited antitumor efficiency due to the insufficient reactive oxygen species(ROS)levels at focal sites and the evolvement of antioxidant defense systems.Herein,we develop an albumin-based...Oxidative therapies receive a limited antitumor efficiency due to the insufficient reactive oxygen species(ROS)levels at focal sites and the evolvement of antioxidant defense systems.Herein,we develop an albumin-based nanomedicine to co-deliver chlorin e6(Ce6)and COH-SR4(CS),which can simultaneously enhance the yield and lethality of intracellular ROS for amplified photodynamic therapy(PDT).In which,CS acts as both an activator of AMP-activated protein kinase(AMPK)and an inhibitor of glutathione S-transferases(GSTs).Benefiting from it,the prepared HSA-Ce6@COH-SR4(HCCS)enables positive feed-back uptake by promoting AMPK phosphorylation,leading to rapid and extensive tumor accumulation of drugs.As a result,HCCS obviously increases the ROS production to elevate intracellular oxidative stress.Furthermore,HCCS can inhibit GSTs to disturb the antioxidant defense system of tumor cells,intensifying the oxidative damage of ROS.Ultimately,the PDT of HCCS is significantly strengthened by improving the ROS yield and lethality,which greatly declines the proliferation of breast cancer in vivo.This study may open a window in the development of drug co-delivery system for enhanced oxidative therapy of tumors.展开更多
The application of microorganisms as probiotics is limited due to lack of safety evaluation.Here,a novel multi-stress-tolerant yeast Meyerozyma guilliermondii GXDK6 with aroma-producing properties was identified from ...The application of microorganisms as probiotics is limited due to lack of safety evaluation.Here,a novel multi-stress-tolerant yeast Meyerozyma guilliermondii GXDK6 with aroma-producing properties was identified from marine mangrove microorganisms.Its safety and probiotic properties were assessed in accordance with phenotype and whole-genome sequencing analysis.Results showed that the genes and phenotypic expression of related virulence,antibiotic resistance and retroelement were rarely found.Hyphal morphogenesis genes(SIT4,HOG1,SPA2,ERK1,ICL1,CST20,HSP104,TPS1,and RHO1)and phospholipase secretion gene(VPS4)were annotated.True hyphae and phospholipase were absent.Only one retroelement(Tad1-65_BG)was found.Major biogenic amines(BAs)encoding genes were absent,except for spermidine synthase(JA9_002594),spermine synthase(JA9_004690),and tyrosine decarboxylase(inx).The production of single BAs and total BAs was far below the food-defined thresholds.GXDK6 had no resistance to common antifungal drugs.Virulence enzymes,such as gelatinase,DNase,hemolytic,lecithinase,and thrombin were absent.Acute toxicity test with mice demonstrated that GXDK6 is safe.GXDK6 has a good reproduction ability in the simulation gastrointestinal tract.GXDK6 also has a strong antioxidant ability,β-glucosidase,and inulinase activity.To sum up,GXDK6 is considered as a safe probiotic for human consumption and food fermentation.展开更多
Fusarium ear rot(FER),caused by Fusarium verticillioides,is a destructive fungal disease of maize.FER resistance is a complex,quantitatively inherited trait controlled by multiple minor-effect genes.In this study,we e...Fusarium ear rot(FER),caused by Fusarium verticillioides,is a destructive fungal disease of maize.FER resistance is a complex,quantitatively inherited trait controlled by multiple minor-effect genes.In this study,we employed two recombinant inbred line(RIL)populations with the common resistant parental line CML304 to identify FER-resistance loci.Initial QTL analysis identified 23 FER-resistance QTL,each explaining 5.21%-30.51%of the total phenotypic variation.Notably,one major QTL,qRfv2,on chromosome 2 was repeatedly detected,accounting for 11.92%-30.51%of the total phenotypic variation.qRfv2 was fine mapped to an interval of 1.01 Mb,flanked by the markers IDP8 and IDP10.qRfv2 is a semidominant resistance gene that could reduce the disease severity index(DSI)by 12.4%-20%,suggesting its potential for enhancing FER resistance in maize.Transcriptome analysis showed that 22 of the 28 annotated functional genes in the qRfv2 region displayed differential expression between parental lines in response to FER.One of the candidate genes,ZmLOX6,was validated to presumably provide a positive effect on FER resistance.Our study provides a basis for the potential cloning and application of FER resistance genes in maize breeding.展开更多
Deprivation of glucose and lactate provides an effective pathway to terminate the nutrients supplement for tumor growth.In this work,biomimetic nanozymes called m@BGLC are constructed for catalytic tumor inhibition th...Deprivation of glucose and lactate provides an effective pathway to terminate the nutrients supplement for tumor growth.In this work,biomimetic nanozymes called m@BGLC are constructed for catalytic tumor inhibition through nutrients deprivation and oxidative damage induction.Concretely,the catalytic enzymes of glucose oxidase(GOx),lactate oxidase(LOx)and chloroperoxidase(CPO)are precrosslinked with bovine serum albumin(BSA)to construct nanozymes,which are then biomimetic functionalized with cancer cell membrane to prepare m@BGLC.Benefiting from the biomimetic camouflage with homologous cell membrane,m@BGLC inherit homotypic binding and immune escape abilities,facilitating the tumor targeting accumulation and preferable cell internalization for improved drug delivery efficiency.Subsequently,under the cascade catalysis of nanozymes,m@BGLC consume glucose and lactate for tumor starvation therapy through nutrients deprivation,and meanwhile,the resulting hyprochloric acid(HClO)causes an oxidative damage of cells to synergistically inhibit tumor growth.In vitro and in vivo findings demonstrate a robust tumor eradication effect of m@BGLC without obvious adverse reactions via the targeted combination therapy.Such cascade catalytic nanomedicine may inspire the development of sophisticated strategies for tumor combination therapy under unfavorable tumor microenvironments.展开更多
Hyperimonates A(1)and B(2),two minor polycyclic polyprenylated acylphloroglucinols(PPAPs)with unprecedented hexahydro-1H-cyclopenta[c]furan-1-one and 2-oxabicyclo[2.2.1]heptane ring system were isolated from Hypericum...Hyperimonates A(1)and B(2),two minor polycyclic polyprenylated acylphloroglucinols(PPAPs)with unprecedented hexahydro-1H-cyclopenta[c]furan-1-one and 2-oxabicyclo[2.2.1]heptane ring system were isolated from Hypericum monogynum.To obtain adequate materials for biological research,the asymmetric total syntheses of 1 and 2 were completed from commercially available geraniol via a bioinspired strategy that features an Au(I)-catalyzed carbometallic cascade cyclization and a Mn(III)/Cu(II)mediated oxidative radical cyclization as vital steps.Biological study implied that compound 1 showed excellent lipid-lowering activity in vitro via inhibiting two signaling pathways,Notch and PPAR,further verified by non-alcoholic fatty liver disease(NAFLD)zebrafish model.These findings provide a new structural template for the treatment of NAFLD and asymmetric synthetic approaches could also facilitate further evaluation for drug development.展开更多
Objective: To evaluate the application value of neutrophils/lymphocytes (NLR), platelets/lymphocytes (PLR), lymphocytes/monocytes (LMR), HEART (history, electrocardiogram, age, risk factors, and troponin) score, and p...Objective: To evaluate the application value of neutrophils/lymphocytes (NLR), platelets/lymphocytes (PLR), lymphocytes/monocytes (LMR), HEART (history, electrocardiogram, age, risk factors, and troponin) score, and point-of- care testing (POCT) in the early warning and precise diagnosis of high-risk chest pain in emergency medicine. Methods: A total of 157 patients with acute chest pain who were admitted to the emergency department and chest pain treatment unit of our hospital between August 2022 and September 2023 were selected. Rapid testing of bedside myocardial markers (ultrasensitive troponin (hs-cTnI), myoglobin (MYO), creatine kinase isoenzyme (CK-MB), D-dimer (D-Dimer), and N-terminal B-type natriuretic peptide precursor (NT-proBNP)) was performed on the patients using a POCT device (ThermoKing BioMQ60proB). A HEART score was used to classify the patients into low (n = 53), intermediate (n = 59), and high-risk (n = 45) groups, and the NLR, PLR, and LMR were calculated. The NLR, PLR, and LMR values were compared among the three groups of patients, and the optimal cutoff values as well as sensitivity and specificity were determined based on receiver operating characteristic (ROC) analysis. Results: The HEART scores of patients in the low-risk, intermediate-risk, and high-risk groups were (2.72 ± 0.24), (4.75 ± 0.56), and (5.32 ± 0.73) respectively, and the differences were statistically significant (P < 0.05). Compared with the low-risk group, the intermediate-risk group and high-risk group had a significantly higher NLR and PLR, and a significantly lower LMR;the high-risk group had higher NLR and PLR and lower values of LMR as compared to the other two groups, and the difference was statistically significant (P < 0.05). The ROC curves suggested that the area under the curve, sensitivity, and specificity of the combined diagnosis of NLR, PLR, LMR, HEART score, and POCT were greater than those of LR, PLR, and LMR with HEART score and POCT alone. Conclusion: The combined application of NLR, PLR, LMR, HEART score, and POCT has significant application value in the early warning and precise diagnosis of emergency high-risk chest pain. It provides a more simple, easy-to-access, and efficient assessment index for the clinical prediction and treatment of emergency high- risk chest pain.展开更多
Despite the gradual transformation of traditional manufacturing by the Human-Robot Collaboration Assembly(HRCA),challenges remain in the robot’s ability to understand and predict human assembly intentions.This study ...Despite the gradual transformation of traditional manufacturing by the Human-Robot Collaboration Assembly(HRCA),challenges remain in the robot’s ability to understand and predict human assembly intentions.This study aims to enhance the robot’s comprehension and prediction capabilities of operator assembly intentions by capturing and analyzing operator behavior and movements.We propose a video feature extraction method based on the Temporal Shift Module Network(TSM-ResNet50)to extract spatiotemporal features from assembly videos and differentiate various assembly actions using feature differences between video frames.Furthermore,we construct an action recognition and segmentation model based on the Refined-Multi-Scale Temporal Convolutional Network(Refined-MS-TCN)to identify assembly action intervals and accurately acquire action categories.Experiments on our self-built reducer assembly action dataset demonstrate that our network can classify assembly actions frame by frame,achieving an accuracy rate of 83%.Additionally,we develop a HiddenMarkovModel(HMM)integrated with assembly task constraints to predict operator assembly intentions based on the probability transition matrix and assembly task constraints.The experimental results show that our method for predicting operator assembly intentions can achieve an accuracy of 90.6%,which is a 13.3%improvement over the HMM without task constraints.展开更多
Supercapacitors known as typical electrochemical capacitors have been considered as one of the most promising candidates of energy storage systems owing to their advantages such as high-power density,long life span an...Supercapacitors known as typical electrochemical capacitors have been considered as one of the most promising candidates of energy storage systems owing to their advantages such as high-power density,long life span and lower production cost.The electrode materials play a crucial role on properties of supercapacitors.Hence,many researches have been focused on the development of novel electrode materials for high-performance supercapacitors.NiCo_2O_4as supercapacitor electrode material has drawn more and more attentions in recent years due to its outstanding advantages,such as high theoretical capacity,low cost,natural abundance and easy of synthesis.However,the NiCo_2O_4always suffer from severe capacity deterioration because of the low electrical conductivity and small surface area.Hence,it is necessary to systematically and comprehensively summarize the progress in understanding and modifying NiCo_2O_4-based materials from various aspects.In this review,the structure and synthesis method of NiCo_2O_4-based materials are discussed in detail.And then,the major goal of this review is to highlight new progress in using proposed strategies to improve the cycling stability and rate capacity of NiCo_2O_4-based materials,including synthesis,control of special morphologies and design of composite materials.Finally,an insight into the future research and development of Ni Co_2O_4-based materials for supercapacitors is prospected.展开更多
Flexible aqueous batteries have been thriving with the growing demand for wearable and portable electrical devices.In particular,flexible aqueous mul tivalent ion batteries(FAMIBs),the charge carriers of which include...Flexible aqueous batteries have been thriving with the growing demand for wearable and portable electrical devices.In particular,flexible aqueous mul tivalent ion batteries(FAMIBs),the charge carriers of which include Zn2+,Al3+,Mg2+,and Ca2+,have great potential for development owing to their high safety,high elemental abundance in the Earth's crust,and a multi-electron redox mechanism with a high theoretical specific capacity.Therefore,for a comprehensive understanding of this developing field,it is necessary to summarize the recent research progress of FAMIBs in a timely manner.Herein,the advancements of the state-of-the-art FAMIBs are reviewed,and the prospects toward this field are also proposed.This study focuses on the rational material and configuration design for FAMIBs in recent studies to achieve high battery performances under deformation conditions,which is elaborated on by classification of the anode,cathode,hydrogel electrolyte,and configurations of FAMIBs.Besides,the electrochemical performance of FAMIBs under flexible conditions is also reviewed from the perspective of their working voltage,specific capacity,and cycling stability.Finally,the ap proaches to improve the performance of FAMIBs are comprehensively eval uated,followed by the outlook on the challenges and opportunities in future development of FAMIBs.展开更多
Mesoporous NiCo_2O_4@MnO_2 nanoneedle arrays as electrode materials for supercapacitor grown on a conductive nickel foam were prepared by a facile hydrothermal route. The interconnected mesoporous structure of the NiC...Mesoporous NiCo_2O_4@MnO_2 nanoneedle arrays as electrode materials for supercapacitor grown on a conductive nickel foam were prepared by a facile hydrothermal route. The interconnected mesoporous structure of the NiCo_2O_4 nanoneedle arrays provides a large specific surface area for charge storage.The electrochemically active MnO_2 nanoparticles covered on the surface of NiCo_2O_4 nanoneedle result in a favorable synergistic storage effect because of charge redistribution at the NiCo_2O_4|MnO_2 interface,which reduces the interfacial polarization and facilitates ion diffusion. The initial specific capacitance of NiCo_2O_4@MnO_2(S2) is 1001 F g-1 at current density of 15 A g-1. The capacity retention of S2 is about87.4% after 4000 cycles, and the specific capacitance of S2 electrode only decreases from 1001 F g-1 to736 F g-1 even after 10,000 cycles. The first-principles calculations show that a chemical bonding between the NiCo_2O_4 and MnO_2 is not only helpful for stabilizing the composites but also leads to a charge redistribution at the interface, which may lead to a smaller interfacial polarization and thus beneficial for the interfacial capacity. The excellent electrochemical performance of NiCo_2O_4@MnO_2 composites(S2)can be ascribed to the high surface area, unique architecture, MnO_2 nanoparticle modification, reduced charge transfer resistance and stable interface between NiCo_2O_4 and MnO_2. The simple material synthesis and architectural design strategy provides new insights in opportunities to exhibit promising potential for practical application in energy storage.展开更多
Volumetric solar evaporations by using light-absorbing nanoparticles suspended in liquids(nanofluids)as solar absorbers have been widely regarded as one of the promising solutions for clean water production because of...Volumetric solar evaporations by using light-absorbing nanoparticles suspended in liquids(nanofluids)as solar absorbers have been widely regarded as one of the promising solutions for clean water production because of its high efficiency and low capital cost compared to traditional solar distillation systems.Nevertheless,previous solar evaporation systems usually required highly concentrated solar irradiation and high capital cost,limiting the practical application on a large scale.Herein,for the first time in this work,polydopamine(PDA)-capped nano Fe3O4(Fe3O4@PDA)nanofluids were used as solar absorbers in a volumetric system for solar evaporation.The introduction of organic PDA to nano Fe3O4highly contributed to the high light-absorbing capacity of over 85%in wide ranges of 200–2400 nm because of the existence of numerous carbon bonds and pi(π)bonds in PDA.As a result,high evaporation efficiency of 69.93%under low irradiation of 1.0 kW m-2was achieved.Compared to other nanofluids,Fe3O4@PDA nanofluids also provided an advantage in high unit evaporation rates.Moreover,Fe3O4@PDA nanofluids showed excellent reusability and recyclability owing to the preassembled nano Fe3O4,which significantly reduced the material consumptions.These results demonstrated that the Fe3O4@PDA nanofluids held great promising application in highly efficient solar evaporation.展开更多
IgG4-related disease(IgG4-RD)is a chronic immune-mediated disorder characterized by progressive tissue fibrosis.Current treatments like glucocorticoids and rituximab focus on remission,yet reversing fibrosis remains c...IgG4-related disease(IgG4-RD)is a chronic immune-mediated disorder characterized by progressive tissue fibrosis.Current treatments like glucocorticoids and rituximab focus on remission,yet reversing fibrosis remains challenging[1,2].While interactions between immune cells and fibroblasts are known to drive fibrosis,the role of epithelial cells remains poorly understood[1].展开更多
Astaxanthin is widely used in aquatic animal feed and has beneficial effects on aquatic animals.Haematococcus pluvialis is one of the most important sources of natural astaxanthin.In this 8-week feeding experiment,the...Astaxanthin is widely used in aquatic animal feed and has beneficial effects on aquatic animals.Haematococcus pluvialis is one of the most important sources of natural astaxanthin.In this 8-week feeding experiment,the impacts of gradient additions of H.pluvialis on the growth and physiological performance of Litopenaeus vannamei before and after acute ammonia nitrogen stress were investigated.The experimental diets were formulated by incorporating gradient levels(0%,0.02%,0.04%,0.08%,0.16%and 0.32%)of H.pluvialis into the feed,namely D0,D0.02,D0.04,D0.08,D0.16 and D0.32,respectively.Each tank housed 30 shrimp,with 4 replicates per group.Significant improvements were observed in weight gain and specific growth rate(P<0.05)in D0.02,D0.04 and D0.08 groups compared with the control group D0.Regression curve analysis indicated that the growth effect of H.pluvialis is maximized at an inclusion level of 0.1006%.The acute ammonia stress test revealed that the addition of H.pluvialis significantly ameliorated the morphology and structure of hepatopancreas in D0.08,D0.16 and D0.32 groups(P<0.05),while attenuating the apoptosis signal in hepatopancreatic cells,thereby indicating a potential alleviation of liver injury and cellular apoptosis induced by acute ammonia stress through the incorporation of a specific proportion of H.pluvialis.The expression levels of ho1 and sod mRNA in the D0.08 group increased after stress,indicating upregulation of antioxidant and immune-related genes(P<0.05).As compared to the control group,the Toll pathway genes exhibited significantly higher expression levels in diets D0.02 and D0.04 prior to stress(P<0.05).After stress,crustin was down-regulated significantly in the H.pluvialis supplemental groups,while tube and relish mRNA expression levels were significantly higher in the D0.32 group compared to the D0 group(P<0.05).The results demonstrated that the growth performance of L.vannamei was enhanced by incorporating 0.02%to 0.08%of H.pluvialis into the diet.Furthermore,dietary supplementation with 0.08%to 0.32%resulted in an increased resistance to ammonia nitrogen stress in L.vannamei.展开更多
基金Project supported by the National Natural Science Foundation of China(51972065)Guangdong Natural Science Foundation(2021A1515010179)。
摘要Near-infrared second window(NIR-Ⅱ;1000-1700 nm)phosphor-converted light-emitting diodes(pc-LEDs)have received substantial attention owing to their widespread applications in night vision,bioimaging,and nondestructive testing.However,efficient NIR-Ⅱbroadband phosphors that can be excited by commercially available blue-LED chips are lacking.Ni2+-activated phosphors typically emit in the NIR-Ⅱregion;however,because of their poor absorption in the blue-light region,their quantum efficiency is low.Herein,Cr3+,Ni2+-coactivated NIR Mg2YVO6(MYVO)double-perovskite phosphors were synthesized via the high-temperature solid-state reaction,realizing double emission in the NIR-ⅠandⅡregions ranging from 700 to 1700 nm.Under 473 nm excitation,owing to the efficient energy transfer(ET)from Cr3+to Ni2+,the MYVO:Cr3+,Ni2+phosphor exhibits an improved NIR-Ⅱemission peak at 1334 nm,demonstrating a full-width at half maximum of 240 nm.Compared with that of MYVO:0.015Ni2+,the internal quantum efficiency of MYVO:0.015Cr3+,0.015Ni2+increases from 15.4%to 42.4%while maintaining excellent overall thermal stability(89.34%at 423 K).Finally,the MYVO:Cr3+,Ni2+phosphor is combined with a 475 nm blue chip to fabricate an NIR pc-LED,demonstrating the potential applications of NIR-Ⅱlight sources in night vision,biological imaging,and spectral analysis.The codoping of Cr3+and Ni2+addresses the issue of the ineffective excitation of Ni2+luminescence by blue light,providing a design approach to the development of numerous ultra-broadband NIR-Ⅱpc-LEDs based on blue-LED chips.
基金financially supported by the National Natural Science Foundation of China(Nos.32270413,82060631,82160808,and 82360035)the Science and Technology Department of Guizhou Province(Nos.QKHJC 2020–1Z076,QKHJC-ZK[2023]YB156,QKHJC-ZK[2021]YB569,and QKHPTRC[2020]5008)+4 种基金Excellent Young Talents Plan of Guizhou Medical University(2023,No.106)the 13thbatch of outstanding young scientific and technological talents in Guizhou Province(No.QKHPTRC[2021]5633)Guizhou Science and Technology Innovation Talent Team(No.QKHPTRC–CXTD[2022]007)High-level Innovative Talents in Guizhou Province(Thousand Levels of Talent for Chunmao Yuan in 2018)the project of State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Medical University(Nos.FAMP202102K and QJJ[2023]113)。
摘要Hymoins A–C(1–3),three unusual polycyclic polyprenylated acylphloroglucinols(PPAPs)were isolated from the flowers of Hypericum monogynum.Hymoin A features the first intriguing 6/5/5/5/7 pentacyclic caged PPAP.Hymoin B is characterized by an unprecedented rearranged 5/6/8 tricyclic ring system,while hymoin C represents the first rearranged PPAP with a fantastic spirocyclic 5/6/7 ring system.Their structures were established by extensive spectroscopic analysis,X-ray crystallography,and computational methods.The plausible biosynthetic routes for the compounds were also proposed.In oleic acid(OA)-induced HepG2 cells,all compounds exhibited significant lipid-lowering activity at the concentrations of 2–8μmol/L.Further mechanistic study implied that compound 1 exhibited excellent lipid-lowering activity in OA-induced HepG2 cells through inhibiting the proteins of free fatty acids synthesis and improving lipidolysis.
基金supported by the grants from the Key Project of Natural Science Foundation of Gansu Province,China(22JR5RA831)the National Natural Science Foundation of China(32460725)the Ningxia Natural Science Foundation Project,China(2024AAC05037)。
摘要Drought stress negatively affects grapevine growth and development.Grafting with rootstock is widely used to improve the quality of grape fruits and confer drought stress tolerance,but the underlying genetics and regulatory mechanisms are unclear.Hence,we investigated the physiologic and transcriptomic profiles in the leaves of grafted SM/1103P(SM shoot/1103P root)and self-rooted SM(‘Shine Muscat')as well as roots of grafted SM/1103P and self-rooted 1103P under drought stress conditions.The results indicated that grafted grapevine effectively attenuated drought damage in grape leaves by increasing phytohormone levels and antioxidant enzyme activities,reducing H2O2 and MDA contents.Transcriptomic profiling revealed a total of 11,855 and 11,197 differentially expressed genes(DEGs)were identified in grape leaves and roots respectively.Weighted correlation network analysis(WGCNA)was performed based on the RNAseq data,and five modules(greenyellow,black,turquoise,salmon and blue)were significantly correlated to drought stress.Pathway analysis showed that DEGs were enriched in the plant hormone signal transduction and MAPK signaling pathway.916 transcription factor genes(TFs)belonging to different gene families were detected that may participate in regulating the drought stress.Quantitative real-time PCR(q RT-PCR)expression analysis of twelve drought stress responsive DEGs was used to verify the transcriptome data.Furthermore,overexpression of Vv MYBPA1 in Arabidopsis thaliana and grape callus tissues improved drought tolerance.Our findings provided new insights into to the regulatory mechanism for improving grapevine adaptation to drought.
基金supported by the National Natural Science Foundation of China(32171884)the Applied Basic Research Foundation of Yunnan Province(202301AS070041)+4 种基金the Major Science and Technology Project of Yunnan Province(202402AE090027)L.Y.acknowledges the Candidates of the Young and Middle-Aged Academic Leaders of Yunnan Province(202105 AC160048)the Ten Thousand Talent Program for Young Topnotch Talents of Yunnan Province(YNWR-QNBJ-2020-136)G.D.acknowledges the 111 Project(D21027)the Yunnan Provincial Academician Workstation(YSZJGZZ-2020052).
摘要Biomass structural materials can effectively address the issues of high energy consumption and environmental degradation brought by traditional engineering structural materials.However,natural structural materials often suffer from drawbacks such as low mechanical performance and flammability.Therefore,this study has developed an ultra-strong fire-resistant bamboo composite(UFBC).Natural bamboo(NB)was used as the raw material.After delignification treatment,bamboo fibers are grafted with epoxy groups through in-situ chemical bonding.Subsequently,polymer chains underwent in-situ chemical cross-linking within the bamboo fiber framework,combined with reinforcement from nano silica,resulting in strengthened cell walls.In addition,the softened and expanded cell walls can facilitate the deposition of phosphate and borate salt on the cell walls,forming an N-P-B flame-retardant system within the system.The tensile strength(463 MPa vs NB 112 MPa)and flexural strength(655 MPa vs NB 157 MPa)of UFBC increased fourfold,with a Limiting Oxygen Index(LOI)of 54.4%.Compared to similar bamboo-based composite materials,UFBC exhibits superior environmental friendliness and sustainability throughout its lifecycle,with all 18 environmental factors being optimized(up to a 92%reduction).This study provides an important reference for the application of high-performance biomass structural materials in construction and industry.
基金funded by the National Natural Science Foundation of China(No.62076044)Scientific Research Foundation of Chongqing University of Technology(No.2020ZDZ015).
摘要Alzheimer’s disease(AD)is a complex,progressive neurodegenerative disorder.The subtle and insidious onset of its pathogenesis makes early detection of a formidable challenge in both contemporary neuroscience and clinical practice.In this study,we introduce an advanced diagnostic methodology rooted in theMed-3D transfermodel and enhanced with an attention mechanism.We aim to improve the precision of AD diagnosis and facilitate its early identification.Initially,we employ a spatial normalization technique to address challenges like clarity degradation and unsaturation,which are commonly observed in imaging datasets.Subsequently,an attention mechanism is incorporated to selectively focus on the salient features within the imaging data.Building upon this foundation,we present the novelMed-3D transfermodel,designed to further elucidate and amplify the intricate features associated withADpathogenesis.Our proposedmodel has demonstrated promising results,achieving a classification accuracy of 92%.To emphasize the robustness and practicality of our approach,we introduce an adaptive‘hot-updating’auxiliary diagnostic system.This system not only enables continuous model training and optimization but also provides a dynamic platform to meet the real-time diagnostic and therapeutic demands of AD.
基金the National Natural Science Foundation of China (Nos. 21672125, 91753122)
摘要Approximately 30% of human cancers are associated with RAS mutation. Ras proteins on the plasma membrane regulate a plenty of important cellular processes. The post-translational modifications(PTMs)of Ras proteins like lipidation and methylation are crucial for their correct cellular localization and biological function. Hence, obtaining Ras proteins with different kinds of modifications is the necessary prerequisite to investigate their biological properties at molecular level. In this review, we mainly summarize the developed strategies including chemical total synthesis, biosynthesis and semi-synthesis for producing Ras proteins with modifications and their application in biological studies.
基金This work was supported in part by the National High Technology Research and Development Program of China (863 Program) (2014A A06A503), the National Natural Science Foundation of China (61422 307, 61473269, 61673361, 61673350), the Scientific Research Starting Foundation for the Returned Overseas Chinese Scholars and Ministry of Education of China, the Youth Innovation Promotion Asso- ciation, Chinese Academy of Sciences, the Youth Top-notch Talent Support Program, the 1000-talent Youth Program, and the Youth Yangtze River Scholarship.
摘要This paper is concerned with the networked predictive control of discrete-time bilinear systems.To deal with the network-induced communication delay that exists in both forward channel(controller to actuator)and feedback channel(sensor to controller),a bilinear networked predictive control scheme is proposed.Then a non-convex optimization problem of solving the predictive control sequence is presented,for which two gradually-optimized algorithms are proposed based on the special structure of bilinear system dynamics model.The numerical simulation indicates that the resulting predictive control sequence can compensate for the network-induced issues actively,which proves the effectiveness of the proposed predictive control strategy.
基金support of National Natural Science Foundation of China(No.52073140)the Guangdong Basic and Applied Basic Research Foundation(No.2022B1515020095).
摘要Oxidative therapies receive a limited antitumor efficiency due to the insufficient reactive oxygen species(ROS)levels at focal sites and the evolvement of antioxidant defense systems.Herein,we develop an albumin-based nanomedicine to co-deliver chlorin e6(Ce6)and COH-SR4(CS),which can simultaneously enhance the yield and lethality of intracellular ROS for amplified photodynamic therapy(PDT).In which,CS acts as both an activator of AMP-activated protein kinase(AMPK)and an inhibitor of glutathione S-transferases(GSTs).Benefiting from it,the prepared HSA-Ce6@COH-SR4(HCCS)enables positive feed-back uptake by promoting AMPK phosphorylation,leading to rapid and extensive tumor accumulation of drugs.As a result,HCCS obviously increases the ROS production to elevate intracellular oxidative stress.Furthermore,HCCS can inhibit GSTs to disturb the antioxidant defense system of tumor cells,intensifying the oxidative damage of ROS.Ultimately,the PDT of HCCS is significantly strengthened by improving the ROS yield and lethality,which greatly declines the proliferation of breast cancer in vivo.This study may open a window in the development of drug co-delivery system for enhanced oxidative therapy of tumors.
基金This research was supported by the Funding Project of Chinese Central Government Guiding to the Guangxi Local Science and Technology Development(GUIKEZY21195021)the Natural Science Fund for Distinguished Young Scholars of Guangxi Zhuang Autonomous Region of China(2019GXNSFFA245011)+3 种基金the Funding Project of Chinese Central Government Guiding to the Nanning Local Science and Technology Development(20231012)the Funding Projects of Guangxi Key Research and Development Plan(GUIKE AB23075173)the Funding Project of Technological Development from Angel Yeast(Chongzuo)Co.,Ltd.(JS1006020230722019)the Innovation Project of Guangxi Graduate Education(YCBZ2021012).
摘要The application of microorganisms as probiotics is limited due to lack of safety evaluation.Here,a novel multi-stress-tolerant yeast Meyerozyma guilliermondii GXDK6 with aroma-producing properties was identified from marine mangrove microorganisms.Its safety and probiotic properties were assessed in accordance with phenotype and whole-genome sequencing analysis.Results showed that the genes and phenotypic expression of related virulence,antibiotic resistance and retroelement were rarely found.Hyphal morphogenesis genes(SIT4,HOG1,SPA2,ERK1,ICL1,CST20,HSP104,TPS1,and RHO1)and phospholipase secretion gene(VPS4)were annotated.True hyphae and phospholipase were absent.Only one retroelement(Tad1-65_BG)was found.Major biogenic amines(BAs)encoding genes were absent,except for spermidine synthase(JA9_002594),spermine synthase(JA9_004690),and tyrosine decarboxylase(inx).The production of single BAs and total BAs was far below the food-defined thresholds.GXDK6 had no resistance to common antifungal drugs.Virulence enzymes,such as gelatinase,DNase,hemolytic,lecithinase,and thrombin were absent.Acute toxicity test with mice demonstrated that GXDK6 is safe.GXDK6 has a good reproduction ability in the simulation gastrointestinal tract.GXDK6 also has a strong antioxidant ability,β-glucosidase,and inulinase activity.To sum up,GXDK6 is considered as a safe probiotic for human consumption and food fermentation.
基金financially funded by the National Natural Science Foundation of China(U2004205)the China Agricultural University-Syngenta Project.
摘要Fusarium ear rot(FER),caused by Fusarium verticillioides,is a destructive fungal disease of maize.FER resistance is a complex,quantitatively inherited trait controlled by multiple minor-effect genes.In this study,we employed two recombinant inbred line(RIL)populations with the common resistant parental line CML304 to identify FER-resistance loci.Initial QTL analysis identified 23 FER-resistance QTL,each explaining 5.21%-30.51%of the total phenotypic variation.Notably,one major QTL,qRfv2,on chromosome 2 was repeatedly detected,accounting for 11.92%-30.51%of the total phenotypic variation.qRfv2 was fine mapped to an interval of 1.01 Mb,flanked by the markers IDP8 and IDP10.qRfv2 is a semidominant resistance gene that could reduce the disease severity index(DSI)by 12.4%-20%,suggesting its potential for enhancing FER resistance in maize.Transcriptome analysis showed that 22 of the 28 annotated functional genes in the qRfv2 region displayed differential expression between parental lines in response to FER.One of the candidate genes,ZmLOX6,was validated to presumably provide a positive effect on FER resistance.Our study provides a basis for the potential cloning and application of FER resistance genes in maize breeding.
基金financial support of Guangdong Basic and Applied Basic Research Foundation(No.2022B1515020095)National Natural Science Foundation of China(No.52073140)。
摘要Deprivation of glucose and lactate provides an effective pathway to terminate the nutrients supplement for tumor growth.In this work,biomimetic nanozymes called m@BGLC are constructed for catalytic tumor inhibition through nutrients deprivation and oxidative damage induction.Concretely,the catalytic enzymes of glucose oxidase(GOx),lactate oxidase(LOx)and chloroperoxidase(CPO)are precrosslinked with bovine serum albumin(BSA)to construct nanozymes,which are then biomimetic functionalized with cancer cell membrane to prepare m@BGLC.Benefiting from the biomimetic camouflage with homologous cell membrane,m@BGLC inherit homotypic binding and immune escape abilities,facilitating the tumor targeting accumulation and preferable cell internalization for improved drug delivery efficiency.Subsequently,under the cascade catalysis of nanozymes,m@BGLC consume glucose and lactate for tumor starvation therapy through nutrients deprivation,and meanwhile,the resulting hyprochloric acid(HClO)causes an oxidative damage of cells to synergistically inhibit tumor growth.In vitro and in vivo findings demonstrate a robust tumor eradication effect of m@BGLC without obvious adverse reactions via the targeted combination therapy.Such cascade catalytic nanomedicine may inspire the development of sophisticated strategies for tumor combination therapy under unfavorable tumor microenvironments.
基金supported by the National Natural Science Foundation of China(22361008,32270413,22061008,82160808)Excellent Young Talents Plan of Guizhou Medical University(2023,No.106,China)+4 种基金Guizhou Provincial Major Scientific and Technological Program([2024]015,China)Guizhou Science and Technology Innovation Talent Team(No.QKHPTRC-CXTD[2022]007,China)2025 Independent Research Project of State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine,Guizhou Medical University(GMUSKL-202503,China)Science and Technology Foundation of Guizhou Province(No.ZK[2021]-039,QKHJC-ZD[2025]027,China)the State Key Laboratory of Functions and Applications of Medicinal Plants,Guizhou Medical University(No.FAMP202102K,China).
摘要Hyperimonates A(1)and B(2),two minor polycyclic polyprenylated acylphloroglucinols(PPAPs)with unprecedented hexahydro-1H-cyclopenta[c]furan-1-one and 2-oxabicyclo[2.2.1]heptane ring system were isolated from Hypericum monogynum.To obtain adequate materials for biological research,the asymmetric total syntheses of 1 and 2 were completed from commercially available geraniol via a bioinspired strategy that features an Au(I)-catalyzed carbometallic cascade cyclization and a Mn(III)/Cu(II)mediated oxidative radical cyclization as vital steps.Biological study implied that compound 1 showed excellent lipid-lowering activity in vitro via inhibiting two signaling pathways,Notch and PPAR,further verified by non-alcoholic fatty liver disease(NAFLD)zebrafish model.These findings provide a new structural template for the treatment of NAFLD and asymmetric synthetic approaches could also facilitate further evaluation for drug development.
摘要Objective: To evaluate the application value of neutrophils/lymphocytes (NLR), platelets/lymphocytes (PLR), lymphocytes/monocytes (LMR), HEART (history, electrocardiogram, age, risk factors, and troponin) score, and point-of- care testing (POCT) in the early warning and precise diagnosis of high-risk chest pain in emergency medicine. Methods: A total of 157 patients with acute chest pain who were admitted to the emergency department and chest pain treatment unit of our hospital between August 2022 and September 2023 were selected. Rapid testing of bedside myocardial markers (ultrasensitive troponin (hs-cTnI), myoglobin (MYO), creatine kinase isoenzyme (CK-MB), D-dimer (D-Dimer), and N-terminal B-type natriuretic peptide precursor (NT-proBNP)) was performed on the patients using a POCT device (ThermoKing BioMQ60proB). A HEART score was used to classify the patients into low (n = 53), intermediate (n = 59), and high-risk (n = 45) groups, and the NLR, PLR, and LMR were calculated. The NLR, PLR, and LMR values were compared among the three groups of patients, and the optimal cutoff values as well as sensitivity and specificity were determined based on receiver operating characteristic (ROC) analysis. Results: The HEART scores of patients in the low-risk, intermediate-risk, and high-risk groups were (2.72 ± 0.24), (4.75 ± 0.56), and (5.32 ± 0.73) respectively, and the differences were statistically significant (P < 0.05). Compared with the low-risk group, the intermediate-risk group and high-risk group had a significantly higher NLR and PLR, and a significantly lower LMR;the high-risk group had higher NLR and PLR and lower values of LMR as compared to the other two groups, and the difference was statistically significant (P < 0.05). The ROC curves suggested that the area under the curve, sensitivity, and specificity of the combined diagnosis of NLR, PLR, LMR, HEART score, and POCT were greater than those of LR, PLR, and LMR with HEART score and POCT alone. Conclusion: The combined application of NLR, PLR, LMR, HEART score, and POCT has significant application value in the early warning and precise diagnosis of emergency high-risk chest pain. It provides a more simple, easy-to-access, and efficient assessment index for the clinical prediction and treatment of emergency high- risk chest pain.
摘要Despite the gradual transformation of traditional manufacturing by the Human-Robot Collaboration Assembly(HRCA),challenges remain in the robot’s ability to understand and predict human assembly intentions.This study aims to enhance the robot’s comprehension and prediction capabilities of operator assembly intentions by capturing and analyzing operator behavior and movements.We propose a video feature extraction method based on the Temporal Shift Module Network(TSM-ResNet50)to extract spatiotemporal features from assembly videos and differentiate various assembly actions using feature differences between video frames.Furthermore,we construct an action recognition and segmentation model based on the Refined-Multi-Scale Temporal Convolutional Network(Refined-MS-TCN)to identify assembly action intervals and accurately acquire action categories.Experiments on our self-built reducer assembly action dataset demonstrate that our network can classify assembly actions frame by frame,achieving an accuracy rate of 83%.Additionally,we develop a HiddenMarkovModel(HMM)integrated with assembly task constraints to predict operator assembly intentions based on the probability transition matrix and assembly task constraints.The experimental results show that our method for predicting operator assembly intentions can achieve an accuracy of 90.6%,which is a 13.3%improvement over the HMM without task constraints.
基金financially supported by the National Natural Science Foundation of China(nos.51774002 and 51672156)Anhui Provincial Science Fund for Excellent Young Scholars(no.gxyqZD2016066)+2 种基金the National Key Basic Research Program of China(2014CB932400)Guangdong special support program(2015TQ01N401)Shenzhen Technical Plan Project(KQJSCX20160226191136)
摘要Supercapacitors known as typical electrochemical capacitors have been considered as one of the most promising candidates of energy storage systems owing to their advantages such as high-power density,long life span and lower production cost.The electrode materials play a crucial role on properties of supercapacitors.Hence,many researches have been focused on the development of novel electrode materials for high-performance supercapacitors.NiCo_2O_4as supercapacitor electrode material has drawn more and more attentions in recent years due to its outstanding advantages,such as high theoretical capacity,low cost,natural abundance and easy of synthesis.However,the NiCo_2O_4always suffer from severe capacity deterioration because of the low electrical conductivity and small surface area.Hence,it is necessary to systematically and comprehensively summarize the progress in understanding and modifying NiCo_2O_4-based materials from various aspects.In this review,the structure and synthesis method of NiCo_2O_4-based materials are discussed in detail.And then,the major goal of this review is to highlight new progress in using proposed strategies to improve the cycling stability and rate capacity of NiCo_2O_4-based materials,including synthesis,control of special morphologies and design of composite materials.Finally,an insight into the future research and development of Ni Co_2O_4-based materials for supercapacitors is prospected.
基金supported by the National Natural Science Foundation of China(51822201,52172178,and 21972007).
摘要Flexible aqueous batteries have been thriving with the growing demand for wearable and portable electrical devices.In particular,flexible aqueous mul tivalent ion batteries(FAMIBs),the charge carriers of which include Zn2+,Al3+,Mg2+,and Ca2+,have great potential for development owing to their high safety,high elemental abundance in the Earth's crust,and a multi-electron redox mechanism with a high theoretical specific capacity.Therefore,for a comprehensive understanding of this developing field,it is necessary to summarize the recent research progress of FAMIBs in a timely manner.Herein,the advancements of the state-of-the-art FAMIBs are reviewed,and the prospects toward this field are also proposed.This study focuses on the rational material and configuration design for FAMIBs in recent studies to achieve high battery performances under deformation conditions,which is elaborated on by classification of the anode,cathode,hydrogel electrolyte,and configurations of FAMIBs.Besides,the electrochemical performance of FAMIBs under flexible conditions is also reviewed from the perspective of their working voltage,specific capacity,and cycling stability.Finally,the ap proaches to improve the performance of FAMIBs are comprehensively eval uated,followed by the outlook on the challenges and opportunities in future development of FAMIBs.
基金financially supported by the National Natural Science Foundation of China (nos. 51774002 and 21773060)Anhui Provincial Science Fund for Excellent Young Scholars (no. gxyqZD2016066)
摘要Mesoporous NiCo_2O_4@MnO_2 nanoneedle arrays as electrode materials for supercapacitor grown on a conductive nickel foam were prepared by a facile hydrothermal route. The interconnected mesoporous structure of the NiCo_2O_4 nanoneedle arrays provides a large specific surface area for charge storage.The electrochemically active MnO_2 nanoparticles covered on the surface of NiCo_2O_4 nanoneedle result in a favorable synergistic storage effect because of charge redistribution at the NiCo_2O_4|MnO_2 interface,which reduces the interfacial polarization and facilitates ion diffusion. The initial specific capacitance of NiCo_2O_4@MnO_2(S2) is 1001 F g-1 at current density of 15 A g-1. The capacity retention of S2 is about87.4% after 4000 cycles, and the specific capacitance of S2 electrode only decreases from 1001 F g-1 to736 F g-1 even after 10,000 cycles. The first-principles calculations show that a chemical bonding between the NiCo_2O_4 and MnO_2 is not only helpful for stabilizing the composites but also leads to a charge redistribution at the interface, which may lead to a smaller interfacial polarization and thus beneficial for the interfacial capacity. The excellent electrochemical performance of NiCo_2O_4@MnO_2 composites(S2)can be ascribed to the high surface area, unique architecture, MnO_2 nanoparticle modification, reduced charge transfer resistance and stable interface between NiCo_2O_4 and MnO_2. The simple material synthesis and architectural design strategy provides new insights in opportunities to exhibit promising potential for practical application in energy storage.
基金financial support from the National Natural Science Foundation of China(No.51704220,No.51974216 and No.51674183)for this work
摘要Volumetric solar evaporations by using light-absorbing nanoparticles suspended in liquids(nanofluids)as solar absorbers have been widely regarded as one of the promising solutions for clean water production because of its high efficiency and low capital cost compared to traditional solar distillation systems.Nevertheless,previous solar evaporation systems usually required highly concentrated solar irradiation and high capital cost,limiting the practical application on a large scale.Herein,for the first time in this work,polydopamine(PDA)-capped nano Fe3O4(Fe3O4@PDA)nanofluids were used as solar absorbers in a volumetric system for solar evaporation.The introduction of organic PDA to nano Fe3O4highly contributed to the high light-absorbing capacity of over 85%in wide ranges of 200–2400 nm because of the existence of numerous carbon bonds and pi(π)bonds in PDA.As a result,high evaporation efficiency of 69.93%under low irradiation of 1.0 kW m-2was achieved.Compared to other nanofluids,Fe3O4@PDA nanofluids also provided an advantage in high unit evaporation rates.Moreover,Fe3O4@PDA nanofluids showed excellent reusability and recyclability owing to the preassembled nano Fe3O4,which significantly reduced the material consumptions.These results demonstrated that the Fe3O4@PDA nanofluids held great promising application in highly efficient solar evaporation.
基金supported by the National Natural Science Foundation of China(82271848,823B2037,and 82471829)the Beijing Natural Science Foundation(7232113)+2 种基金the National High Level Hospital Clinical Research Funding(2022-PUMCH-C-006)the National Key Research and Development Program of China(2022YFC2703104)the Peking Union Medical College Hospital Young Reserve Talent Development Program(UHB12076)。
摘要IgG4-related disease(IgG4-RD)is a chronic immune-mediated disorder characterized by progressive tissue fibrosis.Current treatments like glucocorticoids and rituximab focus on remission,yet reversing fibrosis remains challenging[1,2].While interactions between immune cells and fibroblasts are known to drive fibrosis,the role of epithelial cells remains poorly understood[1].
基金supported by the National Key R&D Program of China(2023YFD2402000)the Project of Yunnan Yuncai Jinke Biotechnology Co.,Ltd.,(HT99982023-0347)+1 种基金the Project of Science and Technology of Guangxi Province(AA23062047)the National Key R&D Program of China(2023YFD2401705).
摘要Astaxanthin is widely used in aquatic animal feed and has beneficial effects on aquatic animals.Haematococcus pluvialis is one of the most important sources of natural astaxanthin.In this 8-week feeding experiment,the impacts of gradient additions of H.pluvialis on the growth and physiological performance of Litopenaeus vannamei before and after acute ammonia nitrogen stress were investigated.The experimental diets were formulated by incorporating gradient levels(0%,0.02%,0.04%,0.08%,0.16%and 0.32%)of H.pluvialis into the feed,namely D0,D0.02,D0.04,D0.08,D0.16 and D0.32,respectively.Each tank housed 30 shrimp,with 4 replicates per group.Significant improvements were observed in weight gain and specific growth rate(P<0.05)in D0.02,D0.04 and D0.08 groups compared with the control group D0.Regression curve analysis indicated that the growth effect of H.pluvialis is maximized at an inclusion level of 0.1006%.The acute ammonia stress test revealed that the addition of H.pluvialis significantly ameliorated the morphology and structure of hepatopancreas in D0.08,D0.16 and D0.32 groups(P<0.05),while attenuating the apoptosis signal in hepatopancreatic cells,thereby indicating a potential alleviation of liver injury and cellular apoptosis induced by acute ammonia stress through the incorporation of a specific proportion of H.pluvialis.The expression levels of ho1 and sod mRNA in the D0.08 group increased after stress,indicating upregulation of antioxidant and immune-related genes(P<0.05).As compared to the control group,the Toll pathway genes exhibited significantly higher expression levels in diets D0.02 and D0.04 prior to stress(P<0.05).After stress,crustin was down-regulated significantly in the H.pluvialis supplemental groups,while tube and relish mRNA expression levels were significantly higher in the D0.32 group compared to the D0 group(P<0.05).The results demonstrated that the growth performance of L.vannamei was enhanced by incorporating 0.02%to 0.08%of H.pluvialis into the diet.Furthermore,dietary supplementation with 0.08%to 0.32%resulted in an increased resistance to ammonia nitrogen stress in L.vannamei.