Ferroelectricity,typically arising from ionic displacements in noncentrosymmetric lattices,enables applications in memory devices and sensors.Recent advances in two-dimensional materials and van der Waals heterostruct...Ferroelectricity,typically arising from ionic displacements in noncentrosymmetric lattices,enables applications in memory devices and sensors.Recent advances in two-dimensional materials and van der Waals heterostructures have revealed novel ferroelectric phenome-na,including sliding ferroelectricity and correlation-driven ferroelectricity in moirésuperlattices.In this work,we fabricate and study a MoS2/WSe2 moirésuperlattice device exhibiting a high field-effect mobility of 17650 cm2·V−1·s−1.Electrical transport measurements reveal correlated insulating states accompanied by a prominent and reproducible resistance hysteresis near half-filling.Temperature and displacement field dependence further confirms the correlation-enhanced nature of the hysteresis.Our analysis suggests that displace-ment field-induced metal-to-insulator transition at correlated insulating state coupled with interfacial dipoles enables the observed resistance hysteresis.These results establish correlation enhanced resistance hysteresis near half-filling in a MoS2/WSe2 heterobilayer,offering opportunities for exploring emergent quantum phases and device functionalities.展开更多
Osteosarcoma remains a challenging malignancy due to its aggressive metastasis and resistance to conventional therapies.But the integration of nanotechnology with traditional Chinese medicine offers a transformative a...Osteosarcoma remains a challenging malignancy due to its aggressive metastasis and resistance to conventional therapies.But the integration of nanotechnology with traditional Chinese medicine offers a transformative approach to overcoming challenges in herbal utilization and cancer therapy.Here,we report the discovery of self-assembled nanoparticles formed during the co-decoction of pyritum and corni fructus,representing a novel mechanism underlying traditional Chinese medicine synergy.Notably,the nanoparticles demonstrate magnetic resonance imaging(MRI)capability with a high T1relaxation rate and low r21ratio(1.53),positioning them as promising T1contrast agents.Inspired by this natural self-assembly process,we engineer a pH-responsive nanoplatform by conjugating gallic acid,polydopamine,and alendronate onto porous FeS2nanoparticles(FGPA).FGPA achieves multi-therapy through drug release,photothermal ablation,H2S-mediated bioenergetic collapse,and ferroptosis induction.In vivo orthotopic models demonstrate almost tumor regression treated with FGPA and near-infrared irradiation,while maintaining biosafety.Additionally,FGPA serves as a dual-modal photoacoustic(PA)/MRI contrast agent,enabling image-guided therapy with pH-responsive T1relaxation enhancement.This work bridges traditional Chinese medicine and nanotechnology,establishing a paradigm for developing multifunctional traditional Chinese medicine-based theranostic agents.展开更多
Stellar ranging is the basis for stellar dynamics research and in-depth research on astrophysics. The parallax method is the most widely used and important basic method for stellar ranging. However, it needs to perfor...Stellar ranging is the basis for stellar dynamics research and in-depth research on astrophysics. The parallax method is the most widely used and important basic method for stellar ranging. However, it needs to perform highprecision measurement of the parallax angle and the baseline length together. We aim to propose a new stellar ranging scheme based on second-order correlation that does not require a parallax angle measurement. We hope our solution can be as basic as the parallax method. We propose a new stellar ranging scheme by using the offset of second-order correlation curve signals. The optical path difference between the stars and different base stations is determined by the offset of the second-order correlation curve signals. Then the distance of the stars could be determined by the geometric relation. With the distance to stars out to 10 kpc away, our astrometric precision can be better compared to Gaia by simulation. We also design an experiment and successfully demonstrate the feasibility of this scheme. This stellar ranging scheme enables further and more accurate stellar ranging without requiring any prior information or angle measurement.展开更多
To the Editor:Acute kidney injury(AKI)is a common public health problem worldwide,which can adversely affect patients’quality of life and even lead to death.[1]Academic hospitals play an important role in admittin...To the Editor:Acute kidney injury(AKI)is a common public health problem worldwide,which can adversely affect patients’quality of life and even lead to death.[1]Academic hospitals play an important role in admitting and providing treatment for patients with AKI,but limited data exist regarding the characteristics of patients in county-level local hospitals.Our research group initiated a comprehensive survey as part of the International Society of Nephrology’s"0 by 25"project(eliminating all deaths related to untreated AKI by 2025)for investigating the disease burden of AKI and its associated risk factors and prognosis through 22 province-level regions of China in 2013.展开更多
基金supported by the National Key R&D Program of China(Grant No.2020YFA0309600)the Research Grants Council(RGC)of Hong Kong(Grant Nos.16303123,C6053-23G-D,AoE/P701/20).
摘要Ferroelectricity,typically arising from ionic displacements in noncentrosymmetric lattices,enables applications in memory devices and sensors.Recent advances in two-dimensional materials and van der Waals heterostructures have revealed novel ferroelectric phenome-na,including sliding ferroelectricity and correlation-driven ferroelectricity in moirésuperlattices.In this work,we fabricate and study a MoS2/WSe2 moirésuperlattice device exhibiting a high field-effect mobility of 17650 cm2·V−1·s−1.Electrical transport measurements reveal correlated insulating states accompanied by a prominent and reproducible resistance hysteresis near half-filling.Temperature and displacement field dependence further confirms the correlation-enhanced nature of the hysteresis.Our analysis suggests that displace-ment field-induced metal-to-insulator transition at correlated insulating state coupled with interfacial dipoles enables the observed resistance hysteresis.These results establish correlation enhanced resistance hysteresis near half-filling in a MoS2/WSe2 heterobilayer,offering opportunities for exploring emergent quantum phases and device functionalities.
基金support from the National Natural Science Foundation of China(No.32025021,52303215)the National Science and Technology Major Project of China(No.2024ZD0525405)+2 种基金the Key Science and Technology Program of the Ministry of Emergency Management of China(No.2024EMST141408)the Science&Technology Bureau of Ningbo City(Nos.2024H006,2023J065)the Zhejiang Provincial Department of Science and Technology(No.2020C03110).
摘要Osteosarcoma remains a challenging malignancy due to its aggressive metastasis and resistance to conventional therapies.But the integration of nanotechnology with traditional Chinese medicine offers a transformative approach to overcoming challenges in herbal utilization and cancer therapy.Here,we report the discovery of self-assembled nanoparticles formed during the co-decoction of pyritum and corni fructus,representing a novel mechanism underlying traditional Chinese medicine synergy.Notably,the nanoparticles demonstrate magnetic resonance imaging(MRI)capability with a high T1relaxation rate and low r21ratio(1.53),positioning them as promising T1contrast agents.Inspired by this natural self-assembly process,we engineer a pH-responsive nanoplatform by conjugating gallic acid,polydopamine,and alendronate onto porous FeS2nanoparticles(FGPA).FGPA achieves multi-therapy through drug release,photothermal ablation,H2S-mediated bioenergetic collapse,and ferroptosis induction.In vivo orthotopic models demonstrate almost tumor regression treated with FGPA and near-infrared irradiation,while maintaining biosafety.Additionally,FGPA serves as a dual-modal photoacoustic(PA)/MRI contrast agent,enabling image-guided therapy with pH-responsive T1relaxation enhancement.This work bridges traditional Chinese medicine and nanotechnology,establishing a paradigm for developing multifunctional traditional Chinese medicine-based theranostic agents.
基金supported by National Key Research and Development Program Earth Observation and Navigation Key Specialities (No. 2018YFB0504300)。
摘要Stellar ranging is the basis for stellar dynamics research and in-depth research on astrophysics. The parallax method is the most widely used and important basic method for stellar ranging. However, it needs to perform highprecision measurement of the parallax angle and the baseline length together. We aim to propose a new stellar ranging scheme based on second-order correlation that does not require a parallax angle measurement. We hope our solution can be as basic as the parallax method. We propose a new stellar ranging scheme by using the offset of second-order correlation curve signals. The optical path difference between the stars and different base stations is determined by the offset of the second-order correlation curve signals. Then the distance of the stars could be determined by the geometric relation. With the distance to stars out to 10 kpc away, our astrometric precision can be better compared to Gaia by simulation. We also design an experiment and successfully demonstrate the feasibility of this scheme. This stellar ranging scheme enables further and more accurate stellar ranging without requiring any prior information or angle measurement.
基金supported by grants from the National Natural Science Foundation of China(Nos.91742205,81625004,and 81860129)the Beijing Young Scientist Program(No.BJJWZYJH01201910001006)the Peking University Clinical Scientist Program by the Fundamental Research Funds for the Central Universities.
摘要To the Editor:Acute kidney injury(AKI)is a common public health problem worldwide,which can adversely affect patients’quality of life and even lead to death.[1]Academic hospitals play an important role in admitting and providing treatment for patients with AKI,but limited data exist regarding the characteristics of patients in county-level local hospitals.Our research group initiated a comprehensive survey as part of the International Society of Nephrology’s"0 by 25"project(eliminating all deaths related to untreated AKI by 2025)for investigating the disease burden of AKI and its associated risk factors and prognosis through 22 province-level regions of China in 2013.