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Metabolic basis of sudden sensorineural hearing loss in diabetes mellitus:From epidemiological association to mechanistic understanding 认领 引用
1
作者 Shu-Fen Li Shu-Yue Yu +2 位作者 Yi-Yuan Liu Shu-Cai Fu Yuan-Ping Xiong 《World Journal of Diabetes》 SCIE 2026年第3期90-100,共11页
Sudden sensorineural hearing loss(SSNHL)is an otologic emergency that necessitates prompt intervention;however,its pathogenesis remains elusive in most cases.Diabetes mellitus,a prevalent systemic metabolic disorder,h... Sudden sensorineural hearing loss(SSNHL)is an otologic emergency that necessitates prompt intervention;however,its pathogenesis remains elusive in most cases.Diabetes mellitus,a prevalent systemic metabolic disorder,has been increasingly implicated in the onset and unfavorable prognosis of SSNHL.Although epidemiological studies have consistently reported this association,the biological plausibility and causal direction of this relationship remain poorly understood and require further investigation.This review demonstrated that dysglycemia contributes to hearing impairment.The underlying mechanisms include vascular injury,auditory neuropathy,microcirculatory dysfunction,chronic inflammation driven by oxidative stress,and the accumulation of advanced glycation end products.Microcirculatory dysfunction may act as a critical nexus that integrates these diverse pathological pathways,ultimately leading to hearing loss.The potential role of prediabetes as an early driver of auditory damage,however,remains to be fully elucidated.Current management of SSNHL involves the use of glucocorticoids,vasodilators,neurotrophic agents,and adjunctive therapies,such as hyperglycemic control and hyperbaric oxygenation.Strengthening basic and translational research is essential to bridge mechanistic insights with clinical practice to develop precise therapeutic strategies to improve outcomes for patients with diabetes mellitus or prediabetes who present with SSNHL. 展开更多
关键词 Sudden sensorineural hearing loss Diabetes mellitus Prediabetes Mechanisms Dysglycemia
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Follicular carcinoma of the thyroid with a single metastatic lesion in the lumbar spine:A case report 认领 引用
2
作者 Yao-Kun Chen Yu-Chun Chen +8 位作者 Wei-Xun Lin Jie-Hua Zheng Yi-Yuan Liu Juan Zou Jie-Hui Cai Ze-Qi Ji Ling-Zhi Chen Zhi-Yang Li Ye-Xi Chen 《World Journal of Clinical Cases》 SCIE 2022年第26期9493-9501,共9页
BACKGROUND The bone is the second most common site of thyroid cancer metastasis,after the lung.Treatment options for bone metastasis of thyroid cancer include surgery,radioiodine therapy(RAIT),external radiation thera... BACKGROUND The bone is the second most common site of thyroid cancer metastasis,after the lung.Treatment options for bone metastasis of thyroid cancer include surgery,radioiodine therapy(RAIT),external radiation therapy,thyroid-stimulating hormone(TSH)inhibition,bisphosphonates,and small-molecule targeted therapies.In most cases,thyroid carcinoma is found in the thyroid tissue;reports of follicular thyroid carcinoma with a single metastasis to the lumbar spine are rare.CASE SUMMARY We report a case of bone metastasis as the only clinical manifestation of thyroid cancer.The patient was a 67-year-old woman with lumbar pain for 7 years and aggravation with intermittent claudication who had previously undergone partial thyroidectomy of a benign thyroid lesion.No abnormal nodules were found in the bilateral thyroid glands.However,imaging studies were consistent with a spinal tumor,and the lesion was diagnosed as a metastatic follicular carcinoma of thyroid origin.We adopted a multidisciplinary collaboration and comprehensive treatment approach.The patient underwent lumbar spine surgery,total resection of the thyroid,postoperative TSH suppression therapy,and RAIT.There were no complications associated with the operation,and the patient had good postoperative recovery.She has experienced no recurrence.CONCLUSION Follicular thyroid carcinoma is associated with early hematogenous metastasis,and the bone is a typical site of metastasis.Single bone metastasis is not a contraindication to medical procedures,and providing the appropriate therapy can result in better outcomes and quality of life for these patients. 展开更多
关键词 Case report Thyroid carcinoma Lumbar spine Metastasis Surgery
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Nomogram for predicting overall survival in Chinese triple-negative breast cancer patients after surgery 认领 引用
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作者 Wei-Xun Lin Yan-Na Xie +6 位作者 Yao-Kun Chen Jie-Hui Cai Juan Zou Jie-Hua Zheng Yi-Yuan Liu Zhi-Yang Li Ye-Xi Chen 《World Journal of Clinical Cases》 SCIE 2022年第31期11338-11348,共11页
BACKGROUND There are few nomograms for the prognosis of Chinese patients with triplenegative breast cancer(TNBC).AIM To construct and validate a nomogram for overall survival(OS)of Chinese TNBC patients after surgery.... BACKGROUND There are few nomograms for the prognosis of Chinese patients with triplenegative breast cancer(TNBC).AIM To construct and validate a nomogram for overall survival(OS)of Chinese TNBC patients after surgery.METHODS This study used the data of SEER*stat 8.3.5 and selected Chinese patients with TNBC operated on between 2010 and 2015.Univariate and multivariate Cox proportional hazard regression models were used.The identified variables were integrated to form a predictive nomogram and risk stratification model;it was assessed with C-indexes and calibration curves.RESULTS The median and maximal OS of the 336 patients was 39 and 83 mo,respectively.The multivariate analysis showed that age(P=0.043),marital status(P=0.040),tumor localization(P=0.030),grade(P=0.035),T classification(P=0.012),and N classification(P=0.002)were independent prognostic factors.The six variables were combined to construct a 1-,3-and 5-year OS nomogram.The C-indexes of the nomogram to predict OS were 0.766 and compared to the seventh edition staging system,which was higher(0.766 vs 0.707,P<0.001).In order to categorize patients into different prognostic groups,a risk stratification model was created.There was a significant difference between the Kaplan–Meier curves of the entire cohort and each disease stage according to the nomogram.CONCLUSION The nomogram provided prognostic superiority over the traditional tumor,node and metastasis system.It could help clinicians make individual OS or risk predictions for Chinese TNBC patients after surgery. 展开更多
关键词 Triple-negative breast cancer Chinese nomogram Risk stratification Overall survival
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A randomized placebo-controlled trial of Chinese medicine acupoint application on gastrointestinal dysfunction after appendectomy 认领 引用
4
作者 Hong Chen Yi-Yuan Liu +6 位作者 Yu-Tao Wang Cheng-Cheng Yang Xiu-Qin Xu Hai-Rong Hu Yun-Lan Jiao Xing-Tong Bao Ling Tang 《TMR Non-Drug Therapy》 2020年第4期158-164,共7页
Background:Gastrointestinal dysfunction is one of the common complications of appendectomy,which seriously affects the postoperative recovery and clinical prognosis.Through traditional Chinese medicine acupoint applic... Background:Gastrointestinal dysfunction is one of the common complications of appendectomy,which seriously affects the postoperative recovery and clinical prognosis.Through traditional Chinese medicine acupoint application is suggested for managing postoperative gastrointestinal dysfunction,supporting evidence is weak.Here,the prospective randomized placebo-controlled study was designed to provide high-level evidence regarding whether traditional Chinese medicine acupoint application is effective on the gastrointestinal dysfunction after appendectomy.Methods:A total of 60 patients who underwent appendectomy in Dongfang Hospital Beijing University of Chinese Medicine(Beijing,China)from November 2016 to December 2017 were selected as study objects and randomly divided into control group(n=30)and observation group(n=30).Based on routine postoperative care,the acupoints Zusanli(ST36)and Yongquan(KI1)were selected.The control group was given acupoint application of traditional Chinese medicine placebo and the observation group was given acupoint application of clinical empirical Chinese medicine called Wentongliqi prescription.The course of treatment was performed on the 1st,2nd,and 3rd days after appendectomy,once a day and 4 hours each time.The primary outcome includes the time until the recovery time of bowel sounds(h),the first postoperative flatus(h)and first bowel movement time(h)on the 1st,2nd,and 3rd days after appendectomy.The secondary outcome includes clinical symptom score,life ability score and adverse reactions were observed and recorded on the 1st,2nd,and 3rd days after appendectomy.Results:After treatment,the recovery time of intestinal sound in the observation group was earlier than that in the control group(P0.05).Conclusion:Acupoint application therapy has limited effect on the recovery of gastrointestinal dysfunction after appendectomy.Further study with large sample size is needed to confirm its therapeutic effects. 展开更多
关键词 Appendicitis Gastrointestinal dysfunction Acupoint sticking therapy Randomized controlled clinical trials Curative effect Security
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