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Identification of key genes affecting porcine fat deposition based on coexpression network analysis of weighted genes 认领 引用 被引量：12
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作者 Kai Xing Huatao Liu +4 位作者 Fengxia Zhang Yibing Liu Yong Shi Xiangdong Ding Chuduan Wang 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2022年第1期36-51,共16页
Background:Fat deposition is an important economic consideration in pig production.The amount of fat deposition in pigs seriously affects production efficiency,quality,and reproductive performance,while also affecting... Background:Fat deposition is an important economic consideration in pig production.The amount of fat deposition in pigs seriously affects production efficiency,quality,and reproductive performance,while also affecting consumers’choice of pork.Weighted gene co-expression network analysis(WGCNA)is effective in pig genetic studies.Therefore,this study aimed to identify modules that co-express genes associated with fat deposition in pigs(Songliao black and Landrace breeds)with extreme levels of backfat(high and low)and to identify the core genes in each of these modules.Results:We used RNA sequences generated in different pig tissues to construct a gene expression matrix consisting of 12,862 genes from 36 samples.Eleven co-expression modules were identified using WGCNA and the number of genes in these modules ranged from 39 to 3,363.Four co-expression modules were significantly correlated with backfat thickness.A total of 16 genes(RAD9A,IGF2R,SCAP,TCAP,SMYD1,PFKM,DGAT1,GPS2,IGF1,MAPK8,FABP,FABP5,LEPR,UCP3,APOF,and FASN)were associated with fat deposition.Conclusions:RAD9A,TCAP,SMYD1,PFKM,GPS2,and APOF were the key genes in the four modules based on the degree of gene connectivity.Combining these results with those from differential gene analysis,SMYD1 and PFKM were proposed as strong candidate genes for body size traits.This study explored the key genes that regulate porcine fat deposition and lays the foundation for further research into the molecular regulatory mechanisms underlying porcine fat deposition. 展开更多
关键词 Fat deposition Pigs RNA-seq WGCNA
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Transcriptome sequencing analysis for the identification of stable lncRNAs associated with bovine Staphylococcus aureus mastitis 认领 引用 被引量：5
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作者 Siyuan Mi Yongjie Tang +7 位作者 Gerile Dari Yuanjun Shi Jinning Zhang Hailiang Zhang Xueqin Liu Yibing Liu Usman Tahir Ying Yu 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2022年第2期384-400,共17页
Background:Staphylococcus aureus(S.aureus)mastitis is one of the most difficult diseases to treat in lactating dairy cows worldwide.S.aureus with different lineages leads to different host immune responses.Long non-co... Background:Staphylococcus aureus(S.aureus)mastitis is one of the most difficult diseases to treat in lactating dairy cows worldwide.S.aureus with different lineages leads to different host immune responses.Long non-coding RNAs(lncRNAs)are reported to be widely involved in the progress of inflammation.However,no research has identified stable lncRNAs among different S.aureus strain infections.In addition,folic acid(FA)can effectively reduce inflammation,and whether the inflammatory response caused by S.aureus can be reduced by FA remains to be explored.Methods:lncRNA transcripts were identified from Holstein mammary gland tissues infected with different concentrations of S.aureus(in vivo)and mammary alveolar cells(Mac-T cells,in vitro)challenged with different S.aureus strains.Differentially expressed(DE)lncRNAs were evaluated,and stable DE lncRNAs were identified in vivo and in vitro.On the basis of the gene sequence conservation and function conservation across species,key lncRNAs with the function of potentially immune regulation were retained for further analysis.The function of FA on inflammation induced by S.aureus challenge was also investigated.Then,the association analysis between these keys lncRNA transcripts and hematological parameters(HPs)was carried out.Lastly,the knockdown and overexpression of the important lncRNA were performed to validate the gene function on the regulation of cell immune response.Results:Linear regression analysis showed a significant correlation between the expression levels of lncRNA shared by mammary tissue and Mac-T cells(P<0.001,R2=0.3517).lncRNAs PRANCR and TNK2-AS1 could be regarded as stable markers associated with bovine S.aureus mastitis.Several HPs could be influenced by SNPs around lncRNAs PRANCR and TNK2-AS1.The results of gene function validation showed PRANCR regulates the mRNA expression of SELPLG and ITGB2 within the S.aureus infection pathway and the Mac-T cells apoptosis.In addition,FA regulated the expression change of DE lncRNA involved in toxin metabolism and inflammation to fight against S.aureus infection.Conclusions:The remarkable association between SNPs around these two lncRNAs and partial HP indicates the potentially important role of PRANCR and TNK2-AS1 in immune regulation.Stable DE lncRNAs PRANCR and TNK2-AS1 can be regarded as potential targets for the prevention of bovine S.aureus mastitis.FA supplementation can reduce the negative effect of S.aureus challenge by regulating the expression of lncRNAs. 展开更多
关键词 Bovine mastitis Folic acid Long non-coding RNA Mac-T cells Mammary gland Staphylococcus aureus
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Superhydrophobic Flexible Supercapacitors Formed by Integrating Hydrogel with Functional Carbon Nanomaterials 认领 引用 被引量：8
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作者 Peng Wang Ximin Zhang +3 位作者 Wei Duan Wei Teng Yibing Liu Qing Xie 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2021年第5期1153-1158,共6页
With the rapid development of the wearable electronics,the flexible supercapacitor with high energy density has attracted more and more attentions.From the viewpoint of outdoor and underwater application,this research... With the rapid development of the wearable electronics,the flexible supercapacitor with high energy density has attracted more and more attentions.From the viewpoint of outdoor and underwater application,this research tried to impart the superhydrophobicity to the flexible supercapacitors.The polyvinyl alcohol/HN03 hydrogel was utilized as the electrolyte,which could achieve self-healing capability without the freezinghawing process.Both microscale graphene and nanoscale carbon nanotubes were utilized as the electrode materials.After surface modification,the hydrophobic suspension composed of graphene and carbon nanotubes was sprayed onto the two sides of hydrogel electrolyte to construct superhydrophobic electrode.Hence,the superhydrophobicity endows the supercapacitor with outstanding self-cleaning performance.The all-in-one structure endows the supercapacitor with improved capacitive ability,outstanding flexibility,good anti-abrasion property,and reliable self-healing capability.The combination of superhydro-phobicity and flexible energy storage might have a broad application for the outdoor and underwater wearable electronics applications. 展开更多
关键词 Supercapacitor Superhydrophobic Hydrogel Self-healing Graphene
Metal−Organic Framework-Based Ultrafast Logic Gates for High-Security Optical Encryption 认领 引用 被引量：2
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作者 Junhong Yu Yadong Han +7 位作者 Longyu Wang Yibing Liu Hang Zhang Xuan Chen Xuezhi Liu Zhengbang Wang Jianbo Hu 《Ultrafast Science》 2023年第4期35-42,共8页
Optical logic gates call for materials with giant optical nonlinearity to break the current performance bottleneck.Metal–organic frameworks(MOFs)provide an intriguing route to achieve superior optical nonlinearity be... Optical logic gates call for materials with giant optical nonlinearity to break the current performance bottleneck.Metal–organic frameworks(MOFs)provide an intriguing route to achieve superior optical nonlinearity benefitting from structural diversity and design flexibility.However,the potential of MOFs for optoelectronics has been largely overlooked and their applications in optical logic have not been exploited.Here,through temporally manipulating the nonlinear optical absorption process in porphyrin-based MOFs,we have successfully developed AND and XOR logic gates with an ultrafast speed approaching 1 THz and an on–off ratio above 90%.On this basis,all-optical information encryption is further demonstrated using transmittance as primary codes,which shows vast prospects in avoiding the disclosure of security information.To the best of our knowledge,this is the first exploration of MOFs for applications in ultrafast optical logic devices and information encryption. 展开更多
关键词 Metal-organic framework Ultrafast Logic gate Optical Encryption Nonlinear optics Carrier dynamics
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