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Single-Nucleus Transcriptomic Sequencing Revealed Cellular and Molecular Changes in a Pilocarpine-Induced Epilepsy Rat Model 认领 引用
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作者 Ying Wang Yue Wang +3 位作者 Fei Yu Yidi Liu Xin Liu Zhengxu Cai 《Neuroscience Bulletin》 SCIE CAS CSCD 2026年第3期539-558,共20页
Uncovering the underlying process of epileptogenesis is crucial for developing effective treatment strategies for epilepsy.However,the cellular and molecular changes throughout epileptogenesis are not fully understood... Uncovering the underlying process of epileptogenesis is crucial for developing effective treatment strategies for epilepsy.However,the cellular and molecular changes throughout epileptogenesis are not fully understood.In this study,single-nucleus RNA sequencing was performed on the hippocampus,temporal cortex,and thalamus across the acute,latent,and chronic phases in a pilocarpine-induced rat model and controls.We created a comprehensive single-nucleus transcriptomic atlas of rat epileptogenesis,consisting of 311,177 single nuclei.Our analysis revealed distinct transcriptional signatures across the three phases and regions,including significant gene expression changes in the acute phase and critical synaptic and neural network remodeling in the thalamus during the latent phase.Notably,we identified two novel astrocyte clusters during epileptogenesis,with the EX-Astro C3-IN pathway emerging as a potential intervention target.The dataset provides a detailed understanding of the dynamic cellular and molecular landscape of epileptogenesis. 展开更多
关键词 Epileptogenesis Single-nucleus RNA sequencing Pilocarpine-induced epilepsy rat model Latent phase Astrocytes
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The Effect of Binaural Beamforming Technology on Mandarin Speech Recognition in Babble Noise for Bimodal Hearing CI users 认领 引用
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作者 Aiting Chen Mengdi Hong +17 位作者 Jianan Li Qian Wang Nan Li Lumeng Han Qian Wu Haihong Liu Yidi Liu Yue Long Fangxia Hu Jianfen Luo Lei Xu Zhaomin Fan Peng Lin Wei Wang Yue Wang Yu Chen Zhaohui Hou Fei Ji 《Journal of Otology》 CSCD 2025年第3期157-161,共5页
PurposeThe purpose of the study was to investigate the effect of bimodal beamforming on speech recognition and comfort for cochlear implant (CI) users with the bimodal hearing solution made up by linking a hearing aid... PurposeThe purpose of the study was to investigate the effect of bimodal beamforming on speech recognition and comfort for cochlear implant (CI) users with the bimodal hearing solution made up by linking a hearing aid to the CI sound processor.Methods19 subjects participated in this study. Speech tests were conducted in quiet and in noisy environments, with the target speech presented from 0° and the noise signal from 45°. Speech recognition thresholds (SRTs) were compared among the previously used bimodal hearing configuration (baseline, any CI sound processor plus any hearing aid), the Naída Bimodal Hearing Solution with omnidirectional microphone, and with directional microphone (so called StereoZoom) switched on. In addition, the study participants provided subjective feedback on their hearing impressions.ResultsThe SRT results showed no significant difference among the three hearing conditions in the quiet environment. No significant improvement was reported when using Naída bimodal system with omnidirectional microphone in noise compared to the baseline (p=0.27). When applying StereoZoom, SRT in noise showed significant improvements compared to omnidirectional settings (p<0.05). Subjective feedback showed that 13 participants were satisfied with Naída Bimodal Hearing Solution, and wanted to continue using it after the trial.ConclusionThe Naída Bimodal Hearing Solution with the same pre-processing algorithm can provide satisfying hearing performance. Beamforming technology can further improve speech perception in noisy environments. 展开更多
关键词 bimodal Cochlear Implant speech recognition beamforming directional microphone
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Comparative study on Photobiomodulation between 630 nm and 810 nm LED in diabetic wound healing both in vitro and in vivo 认领 引用 被引量：2
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作者 Hongyou Zhao Tengda Ji +8 位作者 Tianzhen Sun Haolin Liu Yidi Liu Defu Chen Ying Wang Yizhou Tan Jing Zeng Haixia Qiu Ying Gu 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2022年第2期58-67,共10页
Photobiomodulation(PBM)promoting wound healing has been demonstrated by many studies.Currently,630 nm and 810 nm light-emitting diodes(LEDs),as light sources,are frequently used in the treatment of diabetic foot ulcer... Photobiomodulation(PBM)promoting wound healing has been demonstrated by many studies.Currently,630 nm and 810 nm light-emitting diodes(LEDs),as light sources,are frequently used in the treatment of diabetic foot ulcers(DFUs)in clinics.However,the dose-effect relationship of LED-mediated PBM is not fully understood.Furthermore,among the 630 nm and 810 nm LEDs,which one gets a better effect on accelerating the wound healing of diabetic ulcers is not clear.The aim of this study is to evaluate and compare the effects of 630 nm and 810 nm LED-mediated PBM in wound healing both in vitro and in vivo.Our results showed that both 630 nm and 810 nm LED irradiation significantly promoted the proliferation of mouse fibroblast cells(L929)at different light irradiances(1,5,and 10 mW/cm2).The cell proliferation rate increased with the extension of irradiation time(100,200,and 500 s),but it decreased when the irradiation time was over 500 s.Both 630 nm and 810nm LED irradiation(5 mW/cm2)significantly improved the migration capability of L929 cells.No difference between 630 nm and 810 nm LED-mediated PBM in promoting cell proliferation and migration was detected.In vivo results presented that both 630 nm and 810 nm LED irradiation promoted the wound healing and the expression of the vascular endothelial growth factor(VEGF)and transforming growth factor(TGF)in the wounded skin of type 2 diabetic mice.Overall,these results suggested that LED-mediated PBM promotes wound healing of diabetic mice through promoting fibroblast cell proliferation,migration,and the expression of growth factors in the wounded skin.LEDs(630 nm and 810 nm)have a similar outcome in promoting wound healing of type 2 diabetic mice. 展开更多
关键词 Photobiomodulation(PBM) light-emitting diode(LED) wound healing diabetic ulcers
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Tissue optical clearing enhances efficacy of vascular targeted photodynamic therapy of mouse dorsal skin 认领 引用 被引量：1
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作者 Ying Liu Qiushi Wang +5 位作者 Yidi Liu Ying Wang Haixia Qiu Dan Zhu Ying Gu Defu Chen 《Journal of Innovative Optical Health Sciences》 SCIE EI CSCD 2024年第2期67-78,共12页
Vascular-targeted photodynamic therapy(V-PDT)is an effective treatment for port wine stains(PWS).However,repeated treatment is usually needed to achieve optimal treatment outcomes,possibly due to the limited treatment... Vascular-targeted photodynamic therapy(V-PDT)is an effective treatment for port wine stains(PWS).However,repeated treatment is usually needed to achieve optimal treatment outcomes,possibly due to the limited treatment light penetration depth in the PWS lesion.The optical clearing technique can increase light penetration in depth by reducing light scattering.This study aimed to investigate the V-PDT in combination with an optical clearing agent(OCA)for the therapeutic enhancement of V-PDT in the rodent skinfold window chamber model.Vascular responses were closely monitored with laser speckle contrast imaging(LSCI),optical coherence tomography angiography,and stereo microscope before,during,and after the treatment.We further quantitatively demonstrated the effects of V-PDT in combination with OCA on the blood flow and blood vessel size of skin microvasculature.The combination of OCA and V-PDT resulted in significant vascular damage,including vasoconstriction and the reduction of blood flow.Our results indicate the promising potential of OCA for enhancing V-PDT for treating vascular-related diseases,including PWS. 展开更多
关键词 Vascular-targeted photodynamic therapy(V-PDT) optical clearing agent(OCA) treatment efficacy enhancement skin-fold window chamber port wine stains
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Smartphone-assisted portable colorimetric detection of Salmonella based on a dual signal amplification mediated nanozyme cascade aptasensor 认领 引用
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作者 Qing Kang Chenjing Ma +6 位作者 Yidi Liu Xin Yu Tong Lin Jingbo Jiao Yukun Huang Shuo Wang Xinjun Du 《Food Bioscience》 SCIE 2026年第3期988-995,共8页
Salmonella is a major foodborne pathogen that poses a serious threat to global public health and economic stability.Timely and reliable detection of Salmonella is essential for the effective prevention of foodborne di... Salmonella is a major foodborne pathogen that poses a serious threat to global public health and economic stability.Timely and reliable detection of Salmonella is essential for the effective prevention of foodborne diseases.Herein,a novel ultrasensitive smartphone-based colorimetric aptasensor for Salmonella was reported,leveraging both the strong signal amplification capability of cascade signal amplification technology and the high efficiency of Zr@Cys-Cu dual-enzyme catalysis(with phosphatase-like and laccase-like activities).The exponential amplification(EXPAR)could be specific triggered by Salmonella to form single-stranded target DNA,which further initiated the catalytic hairpin reaction(CHA),leading to the coupling of Fe3O4and Zr@Cys-Cu.After magnetic separation,the collected Fe3O4-Zr@Cys-Cu was used for colorimetric detection,and the final colorimetric signal was processed by a smartphone.The Fe3O4-Zr@Cys-Cu aptasensor demonstrated excellent sensitivity and specificity in detecting Salmonella,with a linear range of 3×10°-3×105CFU/mL and a detection limit of 3×100 CFU/mL.The entire detection process can be completed within 2 h.The system demonstrates the ability to detect analytes in complex sample matrices.Coupled with the portability of smartphones,this aptasensor emerges as a powerful tool for point-of-care testing(POCT),holding broad application potential. 展开更多
关键词 Salmonella Exponential amplification reaction Catalytic hairpin assembly Fe3O4-Zr@Cys-Cu Smartphone
Optogenetic technology:breakthroughs and challenges from basic research to clinical translation 认领 引用
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作者 Hongyou Zhao Hui Yue +8 位作者 Wenxin Chou Shanlin Yang Yidi Liu Mianwang He Yunqi Li Jianfei Guo Haixia Qiu Yilei Xiao Ying Gu 《Advanced Photonics》 SCIE EI CAS CSCD 2025年第5期7-32,共26页
In the past two decades,optogenetic technology has developed to be the most accurate method for investigating or treating neural correlated diseases.Currently,the applications of optogenetic technology have been expan... In the past two decades,optogenetic technology has developed to be the most accurate method for investigating or treating neural correlated diseases.Currently,the applications of optogenetic technology have been expanded from the initial central nervous system to the peripheral nervous system,circulatory system,locomotor system,alimentary system,urinary system,and so on.We summarize the recent progress of optogenetic technology in biomedical applications through two categories:activation or inhibition of neural impulses.The involved diseases include Alzheimer’s disease,ischemic stroke,Parkinson’s disease,epilepsy,spinal cord injury,cardiac arrhythmias,and chronic kidney disease.Furthermore,basic and clinical research in optogenetic technology for visual restoration is highlighted,and the challenges of optogenetic technology for clinical applications are discussed. 展开更多
关键词 biomedical applications photosensitive proteins neuron activation neuron inhibition
Prediction of Bond Dissociation Energy for Organic Molecules Based on a Machine-Learning Approach 认领 引用 被引量：4
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作者 Yidi Liu Yao Li +3 位作者 Qi Yang Jin-Dong Yang Long Zhang Sanzhong Luo 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2024年第17期1967-1974,共8页
Bond dissociation energy(BDE),which refers to the enthalpy change for the homolysis of a specific covalent bond,is one of the basic thermodynamic properties of molecules.It is very important for understanding chemical... Bond dissociation energy(BDE),which refers to the enthalpy change for the homolysis of a specific covalent bond,is one of the basic thermodynamic properties of molecules.It is very important for understanding chemical reactivities,chemical properties and chemical transformations.Here,a machine learning-based comprehensive BDE prediction model was established based on the iBonD experimental BDE dataset and the calculated BDE dataset by St.John et al.Differential Structural and PhysicOChemical(D-SPOC)descriptors that reflected changes in molecules'structural and physicochemical features in the process of bond homolysis were designed as input features. 展开更多
关键词 Bond dissociation energy Machine learning Molecular descriptors Prediction
Topical 5‑aminolevulinic acid‑mediated photodynamic therapy versus loop electrosurgical excision procedure in the treatment of cervical intraepithelial neoplasia 认领 引用 被引量：3
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作者 Yidi Liu Yi Li +5 位作者 Huan Wu Ying Wang Jing Zeng Hui Li Haixia Qiu Ying Gu 《Holistic Integrative Oncology》 2024年第1期107-116,共10页
Objective To compare effectiveness of topical 5-aminolevulinic acid-mediated photodynamic therapy(5-ALA PDT)and loop electrosurgical excision procedure(LEEP)among patients with cervical intraepithelial neoplasia(CIN).... Objective To compare effectiveness of topical 5-aminolevulinic acid-mediated photodynamic therapy(5-ALA PDT)and loop electrosurgical excision procedure(LEEP)among patients with cervical intraepithelial neoplasia(CIN).Methods We retrospectively identified patients who underwent either 5-ALA PDT or LEEP from Sep.2012 to Dec.2019 in Chinese PLA general hospital.Patients’outcomes were compared according to the HPV genotyping,cytologi-cal tests within 3–6-month follow-up post-treatment,the pathological examination would be performed if the cyto-logical results indicated the risk of CIN.Propensity score matching(PSM)was adapted to pair the baseline.Complete remission(CR),partial remission(PR)and the remission rate of HPV infections were used to evaluate the efficacy of 5-ALA PDT versus LEEP.Results In total,30 pairs were matched as the matching tolerance was set as 0.03.There was no significant difference about the CR and PR between 5-ALA PDT and LEEP group(73.33%vs 84.00%,P=0.340;3.33%vs 4.00%,P=1.000).Among different CIN group,there was no statistic difference between 5-ALA PDT and LEEP.Moreover,in terms of HPV remission rate,5-ALA PDT showed the same efficacy as LEEP(59.26%vs 53.85%,P=0.691).Conclusions In essence,topical 5-ALA PDT emerges as a non-invasive,repeatable procedure with minimal side effects for cervical lesions,preserving cervical structure.Overall,the efficacy of 5-ALA PDT is comparable to LEEP in achieving successful outcomes. 展开更多
关键词 5-aminolevulinic acid Photodynamic therapy Loop electrosurgical excision procedure Cervical intraepithelial neoplasia Squamous intraepithelial lesion Human papillomavirus
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